Cosmetic composition for maintaining and restoring skin barrier function

Abstract

The present invention provides a cosmetic composition for maintaining and restoring skin barrier function comprising one or more benzamide compounds of general formula (I) wherein R1 is selected from-OR3 and-NHR3 wherein R3 is H or C1-4 alkyl and R2 is pyridyl.

Description

Technical Field

[0001] This invention relates to cosmetic compositions for maintaining and restoring the skin barrier function, particularly the barrier function of aging skin. Background Technology

[0002] The stratum corneum, as the outermost layer of the epidermis, is the body's first line of defense, playing a vital role as a barrier to protect the skin from external environmental damage.

[0003] The stratum corneum employs multiple strategies to maintain the integrity of the epidermis. The complex organization of the stratum corneum supports the execution of these strategies; it consists of keratinocytes and an intercellular lipid matrix (ceramides, cholesterol, and free fatty acids), both of which originate from the terminal differentiation process of keratinocytes.

[0004] Clearly, the normal development and maintenance of the stratum corneum is crucial for maintaining its barrier function.

[0005] Like many other complex biological systems, skin grows, matures, and ages throughout life. As we age, the appearance and function of the skin change—a process known as intrinsic or chronological aging—and these changes are exacerbated by exposure to external factors such as UVR. Research indicates that the skin's epidermal barrier is disrupted during aging, and functional recovery after damage is slowed. This functional decline can be caused by a variety of mechanisms, including the loss of specific isotype cell adhesion proteins, as well as alterations in cytokine signaling and lipid levels.

[0006] Impaired skin barrier function is widely considered to be at the heart of various problematic skin conditions, including dryness and sensitivity, as well as inflammatory skin diseases such as atopic dermatitis and eczema. Epidermal dysfunction is also thought to contribute to the development of chronic, low-grade systemic inflammation (known as "inflammatory aging"), which is associated with the development of age-related systemic diseases.

[0007] Therefore, there is a need for compositions that can maintain and restore the skin barrier function, especially in aging skin.

[0008] This invention solves the problem. Summary of the Invention

[0009] This invention provides cosmetic compositions for maintaining and restoring skin barrier function, comprising one or more benzamide compounds of general formula (I): (I) R1 is selected from -OR3 and -NHR3, where R3 is H or C. 1-4 Alkyl group, R2 is pyridyl group.

[0010] The present invention also provides a cosmetic method for maintaining and restoring skin barrier function, comprising applying a cosmetic composition as defined above to a skin area to be treated.

[0011] The present invention also provides one or more benzamide compounds of general formula (I) as defined above for cosmetic use as active ingredients for maintaining and restoring skin barrier function. Detailed Implementation

[0012] definition The term "skin" as used in this article refers to the skin of the face, body, and scalp.

[0013] As used in this article, “skin barrier function” refers to the function of the skin in protecting subjects from external hazards, including microbial, chemical, and / or mechanical damage. Various invasive and non-invasive in vitro and in vivo methods for measuring skin barrier function are described in the literature, the most widely used of which is measuring transepidermal water loss (TEWL).

[0014] As used in this article, "skin care" refers to regulating and / or improving the cosmetic quality of the skin, not curing, treating, or preventing diseases or conditions. Therefore, this regulation and / or improvement of such cosmetic qualities applies to both healthy subjects and subjects with skin diseases or conditions (such as psoriasis, lichen planus, folliculitis, or atopic dermatitis).

[0015] Benzamide compounds of general formula (I) In the general formula (I) defined above, R3 is preferably H.

[0016] In the general formula (I) as defined above, R2 is preferably 3-pyridyl.

[0017] Preferred examples of benzamide compounds of general formula (I) include 2-amino-N-3-pyridylbenzamide and 4-hydroxy-N-3-pyridylbenzamide. 2-amino-N-3-pyridylbenzamide is particularly preferred.

[0018] A mixture of any of the above materials may also be used.

[0019] Product Form The cosmetic compositions according to the invention can be formulated in various forms for topical application and generally contain about 0.01 to about 10%, preferably about 0.1 to about 5%, of one or more benzamide compounds of general formula (I) (by weight based on the total weight of the composition).

[0020] The topical cosmetic compositions according to the present invention typically contain a cosmetically acceptable vehicle. The term "cosmetically acceptable" means that the vehicle is suitable for topical application to the skin, has good aesthetics, is compatible with one or more benzamide compounds of general formula (I) and any other ingredients, and does not cause any safety or toxicity problems.

[0021] The medium may comprise an aqueous phase, an oil phase, an alcohol phase, a silicone phase, or a mixture thereof, and may be in emulsion form. The emulsion may have a range of consistency, including thinners (also suitable for sprays or aerosols), pastes, light creams, and heavy creams.

[0022] Exemplary emulsions include water-in-oil emulsions, oil-in-water emulsions, silicone-in-water emulsions, silicone-in-polyol emulsions, polyol-in-silicone emulsions, oil-in-polyol emulsions, polyol-in-oil emulsions, wax-in-water emulsions, and water-oil-water triple emulsions. Preferred emulsions include oil-in-water emulsions and water-in-oil emulsions.

[0023] The topical cosmetic compositions of the present invention, in the form of an emulsion, generally have an oil phase containing one or more cosmetically acceptable fatty materials, which may be liquid or solid at room temperature (25°C).

[0024] Suitable cosmetic-acceptable fatty materials include oils of natural origin (e.g., sunflower seed oil, borage oil, soybean oil, castor oil, olive oil, and almond oil); esters of monohydric or dihydric alcohols and monohydric or polyhydric carboxylic acids, wherein at least one alcohol and / or acid contains at least one hydrocarbon chain with at least 6 carbon atoms (e.g., octyl palmitate, isopropyl myristate, isopropyl palmitate, isostearyl isostearate, hexyl laurate, isohexyl laurate, isohexyl palmitate, decyl oleate, isodecyl oleate, hexadecyl stearate, decyl stearate, dihexyl decyl adipate, lauryl lactate, myristyl lactate, cetyl lactate, oleic acid oleate, oleic acid oleate, myristate oleate, lauryl acetate, cetyl propionate, isononyl isononyl ester, propylene glycol didecanoate, diisopropyl adipate, dibutyl adipate, and oleic acid oleate); ethers (e.g., diethyl ether). Octyl ether (dicaprylether); fatty alcohols (e.g., cetyl alcohol, stearyl alcohol, and behenyl alcohol); isoparaffins (e.g., isooctane, isododecane, and isohexadecane); silicone oils (e.g., dimethyl silicone oil, cyclic silicones, and polysiloxanes); and hydrocarbon oils (e.g., mineral oil, petrolatum, and polyisobutylene); fatty acids containing 8 to 30 carbon atoms (e.g., stearic acid, lauric acid, palmitic acid, and oleic acid); vegetable fats (e.g., cocoa butter, coconut oil, palm oil, and shea butter); natural or synthetic waxes (e.g., lanolin wax, beeswax, carnauba wax, candelilla wax, paraffin wax, lignite wax, microcrystalline wax, pure terrestrial wax, terrestrial wax, and polyethylene wax); hydrogenated oils that are solid at 25°C (e.g., hydrogenated castor oil, hydrogenated jojoba oil, hydrogenated palm oil, hydrogenated tallow, and hydrogenated coconut oil); and fatty esters that are solid at 25°C (e.g., C... 20-40 Alkyl stearate).

[0025] A mixture of any of the above materials may also be used.

[0026] Topical cosmetic compositions according to the present invention, in emulsion form, typically have an aqueous phase, wherein the amount of water in such emulsions is preferably from about 5% to about 95%, and more preferably from about 35% to about 80% (by weight, based on the total weight of the composition). The aqueous phase may also contain one or more organic liquids miscible with water at room temperature (25°C). Exemplary water-miscible organic liquids include monohydric alcohols and polyhydric alcohols and their derivatives, such as C2-C6 alkanols (e.g., ethanol and isopropanol); C2-C... 10 Diols and polyols (e.g., glycerol, propylene glycol, butylene glycol, pentanediol, hexanediol, octyl glycol, dipropylene glycol, and diethylene glycol); C3-C 16 Glycol ethers (such as monopropylene glycol, dipropylene glycol or tripropylene glycol (C1-C4) alkyl ethers and monoethylene glycol, diethylene glycol or triethylene glycol (C1-C4) alkyl ethers) and polyethylene glycol having 2 to 12 ethylene oxide units.

[0027] Topical cosmetic compositions according to the present invention, in emulsion form, typically contain emulsifiers and solubilizers to homogeneously mix two or more immiscible ingredients and to help stabilize the composition. The amount of emulsifier and solubilizer in such emulsions is suitably from about 0.1% to about 30%, preferably from about 1% to about 8% (by weight, based on the total weight of the composition). Emulsifiers that can be used to form O / W or W / O emulsions include sorbitan oleate, sorbitan sesquioleate, sorbitan isostearate, sorbitan trioleate, PEG-20 sorbitan isostearate, polyglycerol-3-diisostearate, oleic acid / isostearate polyglycerol ester, polyglycerol-6-hexaricinoleate, polyglycerol-4-oleate, polyglycerol-4-oleate / PEG-8-propanediol cocoate, polyglycerol-2-dimeric hydroxystearate, PEG-30-dimeric hydroxystearate, oleamide DEA, myristic acid TEA, stearate TEA, magnesium stearate, sodium stearate, potassium laurate, potassium ricinoleate, sodium cocoate, sodium tallow, and potassium ricinoleate. Castorate, sodium oleate, cetyl phosphate, diethanolamine cetyl phosphate, potassium cetyl phosphate, sodium glyceryl oleate phosphate, dimethicone copolyol, cetyl dimethicone copolyol, octyl dimethicone ethoxy glucoside copolyol, dimethicone copolyol crosspolymer, and lauryl dimethicone copolyol.

[0028] A mixture of any of the above materials may also be used.

[0029] The topical cosmetic compositions according to the present invention can also be in the form of skin cleansers, incorporating one or more cleansing surfactants that, when mixed with water and mechanically agitated, produce foam or soap scum. The amount of the cleansing surfactant is suitably from about 5% to about 40%, preferably from about 10% to about 35% (by weight, based on the total weight of the composition). Exemplary cleansing surfactants include anionic surfactants such as ammonium lauroyl sarcosinate, sodium tridecyl ether sulfate, sodium lauroyl sarcosinate, sodium myristyl sarcosinate, ammonium lauryl ether sulfate, sodium lauryl ether sulfate, ammonium dodecyl sulfate, sodium dodecyl sulfate, ammonium cocoyl hydroxyethyl sulfonate, sodium cocoyl hydroxyethyl sulfonate, sodium lauroyl hydroxyethyl sulfonate, sodium cocoyl glycinate, sodium lauroyl glycinate, sodium methyl cocoyl taurate, sodium methyl lauroyl taurate, sodium cetyl sulfate, sodium lauroyl lactylate. lauroyllactylate and triethanolamine lauroyl lactate and mixtures thereof; nonionic surfactants, such as oxidized lauroylamine, oxidized cocoylamine, decyl polydextrose, dodecyl polydextrose, sucrose cocoate and sucrose lauroyl ester and mixtures thereof; and amphoteric surfactants, such as disodium lauroamphodiacetate, sodium lauroamphodiacetate, cetyl dimethyl betaine, cocamidopropyl betaine and cocamidopropyl hydroxysulfonyl betaine and mixtures thereof.

[0030] A mixture of any of the above materials may also be used.

[0031] The topical cosmetic compositions according to the invention can also be formulated in a single-phase carrier, such as water and / or one or more water-miscible organic liquids (e.g., the monohydric alcohols and polyhydric alcohols and their derivatives described above).

[0032] The topical cosmetic compositions according to the present invention can also be formulated in solid form, such as gels or sticks.

[0033] Any combination of the above product forms can also be used.

[0034] Skin care active ingredients The topical cosmetic compositions according to the present invention may contain additional skin-care active substances.

[0035] Examples of skin care benefits in the context of this invention include providing a smoother, flatter texture; improving skin elasticity or resilience; improving skin firmness; improving skin hydration or moisture retention; and reducing redness or the appearance of skin spots.

[0036] Examples of additional skin care active substances suitable for the compositions of the present invention include vitamins, minerals and / or antioxidants, emollients, moisturizers, anti-hyperpigmentation agents, sunscreens, anti-irritants, exfoliants, and mixtures thereof.

[0037] Vitamins, minerals, and / or antioxidants suitable for use in the compositions of this invention include natural plant antioxidants derived from plant materials, such as fruit, vegetable, herb, and flavoring extracts (e.g., wolfberry, white tea, rosemary, green tea, grape seed, and lemongrass extracts); vitamin A and its precursors or derivatives (e.g., β-carotene, retinyl palmitate); vitamin B3 and its precursors or derivatives (e.g., niacinamide); vitamin B5 and its precursors or derivatives (e.g., panthenol and its precursors or derivatives); vitamin C and its precursors or derivatives (e.g., tetrahexyldecyl ascorbate, ascorbyl palmitate); vitamin E and its precursors or derivatives (e.g., d-α-tocopherol, tocopheryl acetate); vitamin K and its precursors or derivatives; selenium and its derivatives (e.g., L-selenomethionine); and α-lipoic acid.

[0038] Emollients suitable for use in the compositions of this invention can increase and retain moisture in the skin by providing a protective coating to prevent epidermal moisture loss. Examples of emollients include C. 10-20 Fatty alcohols and acids (e.g., cetyl alcohol and acid, myristyl alcohol and acid, palmitol and acid, and stearyl alcohol and acid); and C 10-40 Hydrocarbons (such as mineral oil, petrolatum, squalene, and isoparaffins).

[0039] Moisturizers suitable for use in the compositions of this invention increase and retain moisture in the skin by drawing water to the stratum corneum of the epidermis. Examples of moisturizers include amino acids, chondroitin sulfate, glycerin, diglycerides, triglycerides, polyglycerol, polypropylene glycol, polyethylene glycol, ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, hexanediol, 1,3-butanediol, 1,4-butanediol, ethylene glycol monoalkyl ethers, diethylene glycol monoalkyl ethers, erythritol, fructose, glucose, maltose, sucrose, lactose, xylose, inositol, lactitol, xylitol, sorbitol, mannitol, maltitol, panthenol, pentaerythritol, 1,2,6-hexanetriol, honey, hyaluronic acid, hydrogenated honey, hydrogenated starch hydrolysate, natural moisturizing factors, PEG-15 butylene glycol, polyglycerol sorbitol, sodium and potassium salts of pyrrolidone carboxylic acid, sodium glucuronide, trehalose, and urea.

[0040] Anti-hyperpigmentation agents suitable for the compositions of the present invention include natural plant agents derived from plant materials (e.g. Arctostaphylos patula and Arctostaphylos viscida Extracts, Phyllanthus emblica ( Emblica medicinal plant Extracts, Mitracarpus scaber Extracts, Bearberry(Arbutin) extract, Mulberry silkworm (Mulberry) extract, White mulberry (White Mulberry) Extract, Broussonetia papyrifera (Broussonetia papyrifera) extract, licorice extract, acerola cherry extract, chlorella ( Chlorella vulgaris ) extract, Cape Aloe ( Aloe ferrous ) extract and Sorrel ( Western Sorrel Extracts); synthetic or natural glycosamines (e.g., glucosamine, N-acetylglucosamine, glucosamine sulfate, mannosamine, N-acetylglucosamine, galactosamine, N-acetylgalactosamine and their hydrochlorides); retinoids (e.g., retinol, retinaldehyde, retinoic acid and C-type retinol). 2-20 Esters, such as retinyl palmitate, retinyl acetate, retinyl propionate, retinyl linoleate, and retinyl oleate; kojic acid and its C 2-20 Esters (e.g., kojic acid monobutyrate, kojic acid monodecanoate, kojic acid monopalmitate, kojic acid monostearate, and kojic acid monobenzoate); hydroquinone, hydroquinone monomethyl ether, hydroquinone monoethyl ether, hydroquinone monobenzyl ether, α- and β-arbutin, deoxyarbutin (4-[(tetrahydro-2H-pyran-2-yl)oxy]phenol), p-methoxyphenol (4-hydroxyanisole), glutathione, cysteine, N-acetyl-L-cysteine, azelaic acid, magnesium ascorbate phosphate, sodium ascorbate phosphate, peroxides (e.g., hydrogen peroxide, zinc peroxide, sodium peroxide, and peroxide) Benzoyl); 3-aminotyrosine, glycyrrhizic acid, and 4-substituted resorcinol derivatives (e.g., 4-methylresorcinol, 4-ethylresorcinol, 4-propylresorcinol, 4-isopropylresorcinol, 4-butylresorcinol, 4-pentylresorcinol, 4-hexylresorcinol, 4-heptylresorcinol, 4-octylresorcinol, 4-nonylresorcinol, 4-decylresorcinol, 4-undecylresorcinol, 4-dodecylresorcinol, 4-cyclopentylresorcinol, 4-cyclohexylresorcinol, 4-cycloheptylresorcinol, and 4-cyclooctylresorcinol).

[0041] The sunscreens suitable for the compositions of the present invention protect the skin from ultraviolet (UV) solar radiation in the UVB region (wavelength 290 nm to 320 nm) and the UVA region (wavelength 320 nm to 400 nm). Examples of sunscreen agents include methoxycinnamate derivatives (such as octyl methoxycinnamate and isoamyl methoxycinnamate); camphor derivatives (such as 4-methylbenzyl camphor, camphor benzalkonium methyl sulfate, and terephthalimide dicamphor sulfonic acid); salicylate derivatives (such as octyl salicylate and homosalate); sulfonic acid derivatives (such as phenylbenzimidazole sulfonic acid); benzophenone derivatives (such as dioxybenzophenone, sulfoisobenzophenone, and oxybenzophenone); benzoic acid derivatives (such as aminobenzoic acid and octyldimethyl-p-aminobenzoic acid); octocrylene, diethylhexylbutyramide triazinone, octyltriazinone, butyl methoxydibenzoylmethane, cresoltrazol trisiloxane, menthol anthranilate, and inorganic UV-absorbing particles (such as zinc oxide and titanium dioxide).

[0042] Antiirritants suitable for the compositions of the present invention include allantoin, aloe vera, α-bisabolol, caffeine, chamomile extract, Cleaned cola Extracts, cucumber extract, dipotassium glycyrrhizate, glycyrrhizic acid, green tea extract, lecithin or hydrogenated lecithin, licorice extract, Oats (Oat) extract, tea tree oil, salicylic acid, acetylsalicylic acid, strontium acetate, strontium chloride, strontium nitrate, fatty acids with anti-irritant properties (such as linoleic acid and linolenic acid) and aromatic aldehydes with anti-irritant properties (such as 4-methoxybenzaldehyde, 4-ethoxybenzaldehyde, 4-butoxybenzaldehyde and 4-pentoxybenzaldehyde).

[0043] Exfoliating agents suitable for the compositions of the present invention include benzoyl peroxide, benzoic acid, 3-hydroxybenzoic acid, salicylic acid, acetic acid, trichloroacetic acid, 1-pyrrolidone-5-carboxylic acid, α-hydroxy acids (e.g., glycolic acid, lactic acid, malic acid, tartaric acid, and citric acid); β-hydroxy acids (e.g., β-hydroxybutyric acid); α-keto acids (e.g., pyruvic acid, 2-oxopropionic acid, 2-oxobutyric acid, and 2-oxovalerate); and oxacids (e.g., 3,6,9-trioxaundecanedioic acid).

[0044] A mixture of any of the above materials may also be used.

[0045] functional ingredients The topical cosmetic compositions according to the present invention may further contain additional functional ingredients for improving the physical and / or aesthetic properties of the compositions.

[0046] Examples of additional functional ingredients suitable for topical cosmetic compositions according to the present invention include water-soluble or colloidal polymeric thickeners (e.g., hydroxyethyl cellulose, methyl cellulose, hydroxypropyl methyl cellulose, polyquaternium-10, carrageenan, guar gum, hydroxypropyl guar gum, xanthan gum, polyvinyl alcohol, acrylate / ethyl acrylate copolymers, carboxyvinyl polymers, crosslinked polyacrylate polymers, and polyacrylamide polymers); structural clays (e.g., magnesium aluminum silicate, palygorskite, bentonite, montmorillonite, and pyroxene); and inorganic pigments (e.g., titanium dioxide, zirconium oxide, cerium oxide, zinc oxide, iron oxide, chromium oxide, and ferric blue). Blue); organic pigments (e.g., carbon black and barium, strontium, calcium and aluminum lakes); pearlescent agents (e.g., mica coated with titanium dioxide and / or iron oxide); dyes, preservatives (e.g., disodium EDTA, benzyl alcohol, methylparaben, phenoxyethanol, propylparaben, ethylparaben, butylparaben and isobutylparaben); pH adjusters and fragrances.

[0047] A mixture of any of the above materials may also be used.

[0048] Package The topical cosmetic compositions according to the invention can be packaged in suitable containers to suit their viscosity and the intended use by the consumer. For example, lotions or creams can be packaged in bottles or roller applicators, propellant-driven aerosol devices, or containers equipped with pumps suitable for finger operation. When the composition is a cream, it can be simply stored in non-deformable bottles or squeeze containers, such as tubes or cans with lids.

[0049] use The topical cosmetic composition according to the invention can be suitably applied to the skin at a rate of once or twice daily. Generally, the composition is applied evenly to the treatment area twice daily, corresponding to an amount of about 1 to 2 ml per application, for at least 7 days, more preferably at least 30 days.

[0050] The invention is further illustrated by the following non-limiting embodiments.

[0051] Example Barrier function and its development are crucial for normal skin function and health. A series of gene assays were performed on barrier function-related genes to demonstrate the efficacy of compounds of general formula (I) according to the present invention.

[0052] Primary keratinocytes were collected from five donors and placed in 6-well plates at a density of 100,000 cells / well. Cells were grown in KGM-Gold (Lonza) at 37°C and 5% CO2, followed by addition of 1.2 mM Ca. 2+Cells were differentiated for 72 hours. They were then treated for 24 hours with fresh medium containing the medium or medium plus the test compound at a concentration of 10 µm. Following treatment, any effect on cell viability was confirmed by LDH assay on the medium. Cells were washed in PBS, and RNA was isolated using QIAzol (QIAgen) according to the manufacturer's instructions. RNA quantity and quality were measured using Nanodrop and a bioanalyzer before qPCR assessment of specific gene product levels. Test genes were selected to cover various aspects of epidermal function and quantified relative to housekeeping gene levels on the control panel. Positive fold change (log2 FC) values ​​indicated increased expression, while negative fold change indicated decreased expression.

[0053] The genes detected and their expression profiles are shown in Table 1.

[0054] Table 1

[0055] ALOX12B , CERS3 and ELOVL4 The encoded molecules are involved in the synthesis, transport, and metabolism of skin-specific ceramides, which contribute to the formation of the keratinocyte lipid capsule (CLE) and are therefore crucial for skin barrier function.

[0056] KLK11 , KRT10 , LOR and TGM1 The encoded molecules are involved in the process of stratum corneum maturation and are therefore crucial to skin barrier function.

[0057] FLG Encoding filaggrin, a protein crucial for skin barrier integrity, filaggrin participates in the formation of the protein-lipid keratinized cell membrane (CCE), which replaces the plasma membrane of differentiating keratinocytes and is extensively cross-linked by transglutaminase. Ultimately, filaggrin is deiminated and degraded on the skin surface, releasing its constituent amino acids. This produces a hygroscopic amino acid mixture known as natural moisturizing factor (NMF), which contributes to epidermal hydration and skin barrier function.

[0058] CLDN1 It encodes claudin-1, a protein that forms a tight junction between the granular layer and the stratum corneum, and is therefore essential for the integrity of the skin barrier.

[0059] The results in Table 1 above demonstrate that the compound of formula (I) according to the present invention significantly increases the expression of all tested barrier function-related genes.

[0060] Table 2 below lists cosmetic compositions according to the present invention for maintaining and restoring skin barrier function.

[0061] Table 2 Skin care wash

Claims

1. A cosmetic composition for maintaining and restoring skin barrier function, comprising one or more benzamide compounds of general formula (I): （I） R1 is selected from -OR3 and -NHR3, where R3 is H or C. 1-4 Alkyl group, R2 is pyridyl group; And one or more additional skin care active ingredients selected from the following: vitamins, minerals and / or antioxidants, emollients, moisturizers, anti-hyperpigmentation agents, sunscreens, anti-irritants, exfoliants, and mixtures thereof.

2. The cosmetic composition according to claim 1, wherein the benzamide compound of general formula (I) is selected from 2-amino-N-3-pyridylbenzamide and 4-hydroxy-N-3-pyridylbenzamide and mixtures thereof.

3. The cosmetic composition according to claim 2, wherein the benzamide compound of general formula (I) is 2-amino-N-3-pyridylbenzamide.

4. A non-therapeutic cosmetic method for maintaining and restoring skin barrier function, comprising applying a cosmetic composition according to claims 1 to 3 to a skin area to be treated.

5. Non-therapeutic cosmetic uses of one or more benzamide compounds of general formula (I) as active ingredients for maintaining and restoring skin barrier function: （I） R1 is selected from -OR3 and -NHR3, where R3 is H or C. 1-4 Alkyl group, R2 is pyridyl group.

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