Brain regulation device, electronic device, medium, and computer program product

Abstract

The application discloses a brain regulation device, an electronic device, a medium and a computer program product. The device comprises a control module, a mechanical wave emitting module and a magnetic field generating module. The control module is configured to determine a first intensity and a second intensity corresponding to a regulation area of a target object based on an effective induced electric field intensity of the target object. The mechanical wave emitting module is configured to emit mechanical waves with the first intensity to the regulation area. The magnetic field generating module is configured to generate a magnetic field with the second intensity in the regulation area. The embodiments of the application are beneficial to improving the non-invasive neural regulation effect on patients.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of non-invasive neuromodulation, and in particular to a brain regulation device, an electronic device, a medium, and a computer program product. BACKGROUND

[0002] The mainstream way of non-invasive neuromodulation is transcranial magnetic therapy, that is, a coil is placed on the head of a patient, a magnetic field is generated by a transient current, and thus the activity of neurons in the brain of the patient is regulated. However, when transcranial magnetic therapy is performed, some metal objects will interfere with the magnetic field generated by the coil, thereby reducing the treatment effect of non-invasive neuromodulation. However, for the coil, the magnetic field cannot be increased indefinitely by increasing the current. In order to improve the treatment effect of non-invasive neuromodulation, mechanical waves and magnetic fields are used to stimulate the head of the patient at the same time, thereby increasing the neuron stimulation effect on the head of the patient.

[0003] However, when mechanical waves and magnetic fields are used to stimulate the patient at the same time, the patient is stimulated by mechanical waves of a fixed intensity and magnetic fields of a fixed intensity, and the intensity of the mechanical waves and the magnetic fields is not adapted to the patient, and the treatment effect on the patient is still poor. SUMMARY

[0004] The embodiments of the present application provide a brain regulation device, an electronic device, a medium, and a computer program product, which are used for individualized regulation of a target object by using an intensity matched with the target object, and improve the treatment effect on the target object.

[0005] In a first aspect, the embodiments of the present application provide a brain regulation device, comprising:

[0006] a control module, a mechanical wave emitting module, and a magnetic field generating module;

[0007] The control module is configured to determine a first intensity and a second intensity corresponding to a regulation area of a target object based on an effective induced electric field intensity of the target object.

[0008] The mechanical wave emitting module is configured to emit mechanical waves with the first intensity to the regulation area.

[0009] The magnetic field generating module is configured to generate a magnetic field with the second intensity in the regulation area.

[0010] In a second aspect, the embodiments of the present application provide a brain regulation method, comprising:

[0011] determining a first intensity and a second intensity corresponding to a regulation area of a target object based on an effective induced electric field intensity of the target object;

[0012] emitting mechanical waves with the first intensity to the regulation area.

[0013] The magnetic field generated in the regulation region has the second intensity.

[0014] In a third aspect, an electronic device is provided, including: a processor and a memory, the processor being connected with the memory, the memory being configured to store a computer program, and the processor being configured to execute the computer program stored in the memory, so that the electronic device executes the method according to the second aspect.

[0015] In a fourth aspect, a computer readable storage medium is provided, the computer readable storage medium storing a computer program, and the computer program being executed by a processor to implement the method according to the second aspect.

[0016] In a fifth aspect, a computer program product is provided, the computer program product including a computer program, and the computer program being executed by a processor to implement the method according to the second aspect.

[0017] The embodiments of the present application have the following beneficial effects:

[0018] It can be seen that, in the embodiments of the present application, the brain regulation device includes a mechanical wave emitting module and a magnetic field generating module, so that the regulation region of the target object can be stimulated or regulated by the magnetic field and the mechanical wave at the same time, and when the regulation region of the target object is stimulated or regulated by the magnetic field and the mechanical wave at the same time, the control module of the brain regulation device determines the first intensity (i.e., the intensity of the mechanical wave) and the second intensity (i.e., the intensity of the magnetic field) corresponding to the regulation region based on the effective induced electric field intensity of the target object, i.e., the electric field intensity that can cause the brain neurons of the target object to produce an effective response, so that the intensity matched with the target object is determined, and then the mechanical wave emitting module emits mechanical waves with the first intensity to the regulation region, and the magnetic field generating module generates a magnetic field with the second intensity in the regulation region, so that effective stimulation can be generated in the regulation region, i.e., the target object is individually regulated by using the intensity matched with the patient, and the treatment effect on the target object is improved. BRIEF DESCRIPTION OF DRAWINGS

[0019] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed in the embodiment description will be briefly introduced. Obviously, the drawings in the following description are some embodiments of the present application, and other drawings can also be obtained by those skilled in the art without creative labor.

[0020] Figure 1 A schematic diagram of a brain regulation device provided by the embodiments of the present application;

[0021] Figure 2 A schematic diagram of a second angle between the direction of the mechanical wave and the direction of the magnetic field provided for an embodiment of the present application;

[0022] Figure 3 A schematic diagram of a relationship between the pressure value and the time, and time integration of the pressure value to obtain the effective cutting distance provided for an embodiment of the present application;

[0023] Figure 4 A flowchart of a brain regulation method provided for an embodiment of the present application;

[0024] Figure 5 A schematic diagram of an electronic device provided for an embodiment of the present application. DETAILED DESCRIPTION

[0025] The technical solutions in the embodiments of the present application will be described clearly and completely below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are some embodiments of the present application, rather than all the embodiments of the present application. Based on the embodiments in the present application, all the other embodiments obtained by those skilled in the art without creative work fall within the scope of protection of the present application.

[0026] The terms “first”, “second”, “third”, and “fourth” and the like in the specification of the present application and the claims and the drawings are used to distinguish different objects, rather than to describe a particular order. In addition, the terms “include” and “have” and any variations thereof are intended to cover non-exclusive inclusion. For example, a process, method, system, product or device including a series of steps or units is not limited to the listed steps or units, but can optionally include steps or units not listed or can optionally include other steps or units inherent to the process, method, product or device.

[0027] Reference herein to “an embodiment” means that a particular feature, result or characteristic described in connection with an embodiment can be included in at least one embodiment of the present application. The appearance of the phrase in various places in the specification does not necessarily all refer to the same embodiment, nor does it necessarily exclude alternative or additional embodiments. It is explicitly and implicitly understood by those skilled in the art that the embodiments described herein can be combined with other embodiments.

[0028] Reference is made to Figure 1 , Figure 1 A schematic diagram of a brain regulation device provided for an embodiment of the present application. As shown in Figure 1 , the brain regulation device includes a control module, a mechanical wave emitting module, and a magnetic field generating module.

[0029] Optionally, the mechanical wave emitting module is configured to emit a mechanical wave. For example, the mechanical wave emitting module comprises a mechanical probe, and the mechanical wave emitting module emits the mechanical wave through the mechanical probe. Optionally, the mechanical wave mentioned in the present application can be a shock wave or an ultrasonic wave, and accordingly, the mechanical probe can be a shock wave probe or an ultrasonic probe. For the convenience of description, the present application mainly takes the mechanical wave as a shock wave and the mechanical probe as a shock wave probe as an example for illustration, but the type of the mechanical wave and the mechanical probe is not limited. Moreover, the direction of the mechanical wave emitted by the mechanical wave emitting module can be different for different regulation regions, and the specific emission direction depends on the regulation region.

[0030] Optionally, the magnetic field generating module is configured to generate a magnetic field. Optionally, the magnetic field generating module comprises a pair of permanent magnets or a coil. For example, if the magnetic field generating module comprises a pair of permanent magnets, a static magnetic field can be generated by the permanent magnets. For example, if the magnetic field generating module comprises a coil, a magnetic field can be generated by the coil, and the size of the magnetic field can be adjusted by adjusting the size of the coil current, thereby generating a dynamic magnetic field. For the convenience of description, the present application mainly takes the coil to generate a dynamic magnetic field as an example for illustration. The direction of the magnetic field in the present application mainly takes the direction parallel to the ground or the direction perpendicular to the head as an example for illustration.

[0031] For the convenience of understanding the technical solutions of the present application, first, the process of obtaining the effective induced electric field intensity of the target object in the present application is introduced. The target object is a patient who needs to be non-invasively neurologically regulated.

[0032] Optionally, the effective induced electric field intensity of the target object is obtained by stimulating the motion region of the target object for one or more rounds, wherein each round of stimulation comprises multiple stimulations, and the multiple stimulations in each round of stimulation stimulate the motion region using mechanical waves with the same intensity and magnetic fields with the same intensity.

[0033] For example, in each stimulation process of the jth round of stimulation, the mechanical wave emitting module sends a mechanical wave with an intensity I j to the motion region, i.e., emits a mechanical wave with an intensity I j . The magnetic field generating module generates a magnetic field with an intensity B j in the motion region, i.e., generates a magnetic field with an intensity B j . Wherein I j and B j are intensities corresponding to the jth round of stimulation, and j is an integer greater than or equal to 1.

[0034] For example, the control module obtains the effective induced electric field intensity of the target object in each stimulation process of the jth round of stimulation through the mechanical wave with an intensity I j and the magnetic field with an intensity B jThe electromyographic signal of the target object when the magnetic field stimulates the motor area. For example, the brain control device further comprises an electromyographic acquisition module, and the control module can detect the resting-state induced electromyographic activity at the contralateral arm and / or palm of the motor area through the electromyographic acquisition module to acquire the electromyographic signal of the target object. Then, the control module obtains the peak-to-peak value of the electromyographic signal at each stimulation in the jth stimulation, and determines whether the peak-to-peak value at each stimulation is greater than a first threshold value; if it is greater than the first threshold value, the number of times is counted once, and the number of stimulations with a peak-to-peak value greater than the first threshold value in the jth stimulation process is obtained. Then, the control module determines the proportion corresponding to the jth stimulation based on the number of stimulations corresponding to the jth stimulation and the total number of stimulations of the jth stimulation, wherein the proportion is the ratio between the number of stimulations and the total number of stimulations.

[0035] Further, the control module determines whether the proportion corresponding to the jth stimulation is greater than a second threshold value.

[0036] Optionally, if the proportion is less than the second threshold value, the control module adjusts the intensity I j of the mechanical wave corresponding to the j+1th stimulation based on the intensity I j+1 of the mechanical wave corresponding to the jth stimulation. j For example, the intensity I j+1 of the mechanical wave corresponding to the j+1th stimulation is obtained by adjusting the intensity I j of the mechanical wave corresponding to the jth stimulation by a first preset amplitude. For example, the intensity I j+1 of the mechanical wave corresponding to the j+1th stimulation is obtained by increasing the intensity I j of the mechanical wave corresponding to the jth stimulation by the first preset amplitude. j+1 And the control module determines the intensity B j of the magnetic field corresponding to the j+1th stimulation based on the intensity B j+1 of the magnetic field corresponding to the jth stimulation. j For example, the intensity B j+1 of the magnetic field corresponding to the j+1th stimulation is obtained by adjusting the intensity B j of the magnetic field corresponding to the jth stimulation by a second preset amplitude. For example, the intensity B j of the magnetic field corresponding to the j+1th stimulation is obtained by increasing the intensity B j+1 of the magnetic field corresponding to the jth stimulation by the second preset amplitude.

[0037] It should be noted that since the target object is stimulated by the mechanical wave and the magnetic field at the same time, the intensity of any one of the mechanical wave and the magnetic field changes, and the stimulation of the neuron changes. Therefore, after the jth stimulation, only one of the intensity of the mechanical wave or the intensity of the magnetic field can be adjusted to obtain the intensity I j+1 of the mechanical wave corresponding to the j+1th stimulation and the intensity B j+1. Specifically, the intensity that needs to be adjusted can be adjusted in the above manner, and the intensity corresponding to the jth stimulation is taken as the intensity of the j+1th stimulation if the intensity does not need to be adjusted. For example, if only the intensity of the mechanical wave is adjusted, the intensity I j may be adjusted to obtain the intensity I j+1 , and B j is directly taken as the intensity B j+1 ; for example, if only the intensity of the magnetic field is adjusted, the intensity B j may be adjusted to obtain the intensity B j+1 , and I j is directly taken as the intensity I j+1 .

[0038] For ease of description, the present application mainly takes adjusting the intensity of the mechanical wave and the intensity of the magnetic field at the same time as an example for description.

[0039] Further, after the intensity I j+1 and the intensity B j+1 are determined, the control module sends the intensity I j+1 to the mechanical wave emitting module and sends the intensity B j+1 to the magnetic field generating module, so that in each stimulation process of the j+1th stimulation, the mechanical wave emitting module emits the mechanical wave with the intensity I j+1 to the movement area, and the magnetic field generating module generates the magnetic field with the intensity B j+1 in the movement area. Then, the control module obtains the peak-to-peak value of the electromyographic signal at each stimulation in the j+1th stimulation, thereby obtaining the ratio corresponding to the j+1th stimulation, wherein the way of obtaining the ratio corresponding to the j+1th stimulation is similar to the way of obtaining the ratio corresponding to the jth stimulation, and will not be described repeatedly. If the ratio corresponding to the j+1th stimulation is still less than the second threshold, then the ratio of the j+2th stimulation is obtained, and so on, until the determined ratio is greater than or equal to the second threshold.

[0040] It should be noted that when j=1, i.e., when the target object is stimulated for the first time, the control module first obtains the intensity I1 of the mechanical wave corresponding to the first stimulation and the intensity B1 of the magnetic field.

[0041] Optionally, the above I1 and B1 can be pre-set, or can be input to the brain regulation device by the user before the target object is stimulated for the first time. For example, the brain regulation device further comprises a display module, so that the user can set I1 and B1 through the display module, and can also set the above first preset amplitude and second preset amplitude through the display module.

[0042] Optionally, if the ratio is greater than or equal to the second threshold, it indicates that an effective stimulus is generated in the motion region of the target object, and an effective induced electric field intensity is determined based on a first target intensity and a second target intensity, wherein the first target intensity is an intensity of the mechanical wave emitted by the mechanical wave emitting module when the ratio is greater than or equal to the second threshold, and the second target intensity is an intensity of the magnetic field generated by the magnetic field generating module when the ratio is greater than or equal to the second threshold.

[0043] For example, the control module acquires a second angle between a direction in which the mechanical wave emitting module emits the mechanical wave and a direction of the magnetic field generated by the magnetic field generating module, and acquires a second distance between the mechanical wave emitting module and the motion region. Specifically, as shown in Figure 2 , the control module determines, based on the motion region, a direction in which the mechanical wave emitting module emits the mechanical wave by using a neural navigation system, so that the mechanical wave can be emitted to the motion region along the direction. For the direction of the magnetic field, for the convenience of understanding, the direction perpendicular to the brain, i.e., the direction parallel to the ground, is taken as the direction of the magnetic field. Then, for example, as shown in Figure 2 , the control module determines, based on the direction in which the mechanical wave emitting module emits the mechanical wave and the direction of the magnetic field, the second angle, i.e., the included angle between the two directions . The control module determines, by using the neural navigation system, a positioning point of the motion region, and determines, based on the positioning point, the second distance between the mechanical wave emitting module and the motion region.

[0044] Then, the control module determines the effective induced electric field intensity based on the second angle, the second distance, the first target intensity, and the second target intensity.

[0045] For example, the control module determines a cutting speed of the brain tissue based on the first target intensity, the second distance, an attenuation rate of the mechanical wave in the brain tissue, and a propagation speed of the mechanical wave in the brain tissue, wherein the brain tissue mentioned in the present application can also be understood as brain neurons, i.e., neurons of the brain. The cutting speed can be understood as a cutting speed of the brain tissue in the magnetic field generated by the magnetic field generating module, i.e., a motion speed in the magnetic field of the second target intensity.

[0046] For example, the third intensity of the mechanical wave of the first target intensity reaching the motion region is determined based on the first target intensity, the second distance, and the attenuation rate of the mechanical wave in the brain tissue, wherein the third intensity can be understood as an intensity of the mechanical wave of the first target intensity after the attenuation of the brain tissue with a length of the second distance, i.e., an intensity of the mechanical wave reaching the positioning point of the motion region.

[0047] For example, the third intensity can be represented by formula (1):

[0048] Formula (1) is:

[0049] wherein, is the first target intensity, is the decay rate, is the second distance, is the third intensity.

[0050] It should be noted that if the mechanical wave is a shock wave, the shock wave is a kind of instantaneous mechanical wave, and after the emission, the intensity of the shock wave will change nonlinearly with time, so the first target intensity is a strength that changes with time, and this time-varying relationship can be expressed by a function or equation. Therefore, if the first target intensity is a time-varying intensity, it can be expressed by . Accordingly, the third intensity is also a time-varying intensity, so can be substituted into the above formula (1) to obtain the time-varying third intensity, that is, .

[0051] For ease of understanding, the present application mainly takes the mechanical wave emission module emitting mechanical waves of fixed intensity as an example for illustration, that is, the mechanical wave emission module emits mechanical waves of fixed intensity all the time within the preset stimulation duration. Therefore, when the mechanical wave emission module continuously emits mechanical waves of the first target intensity within the preset stimulation duration, mechanical waves of the third intensity will be continuously generated in the motion area.

[0052] Further, based on the third intensity, the density of the brain tissue, and the propagation speed of the mechanical wave in the brain tissue, the pressure value generated by the mechanical wave of the third intensity in the motion area is determined.

[0053] Exemplarily, the pressure value can be represented by formula (2):

[0054] Formula (2) is:

[0055] wherein, P is the pressure value, is the above-mentioned third intensity, is the density of the brain tissue, and c is the propagation speed of the mechanical wave in the brain tissue.

[0056] It can be understood that if the third intensity is time-varying, the above-mentioned pressure value P is also time-varying, and the time-varying pressure value is represented by .

[0057] Further, based on the density of the brain tissue and the above-mentioned propagation speed, the impedance of the brain tissue is determined.

[0058] For example, the impedance of the brain tissue can be represented by equation (3):

[0059] Equation (3);

[0060] wherein Z is the impedance.

[0061] Further, the cutting speed is determined based on the pressure value and the impedance.

[0062] For example, the cutting speed can be represented by equation (4):

[0063] Equation (4);

[0064] wherein V is the cutting speed.

[0065] It can be understood that if the pressure value varies with time, the cutting speed also varies with time, and the cutting speed varying with time is referred to as , then .

[0066] Further, the effective cutting distance of the brain tissue in the magnetic field of the second target intensity is determined based on the cutting speed and a preset stimulation duration. For example, based on the cutting speed and the stimulation duration, the moving distance of the brain tissue in the magnetic field of the second target intensity within the stimulation duration can be determined, and the moving distance is taken as the effective cutting distance.

[0067] For example, the effective cutting distance can be represented by equation (5):

[0068] Equation (5);

[0069] wherein L is the effective cutting distance, and T is the preset stimulation duration.

[0070] It can be understood that if the cutting speed varies with time , then the effective cutting distance L can be represented by equation (6):

[0071] Equation (6);

[0072] wherein L is the effective cutting distance.

[0073] For example, if the mechanical wave is a shock wave, the mechanical wave generated by the mechanical wave in the moving region satisfies the relationship shown in equation (7), then after the mechanical wave is emitted, the Figure 3 can be time-integrated, and the area of the shaded part integrated within the preset stimulation duration T is divided by . An effective cutting distance of the brain tissue, i.e., the brain neuron, can be obtained.

[0074] Further, based on the second target intensity, the effective cutting distance, the cutting speed, and the second angle, the effective induced electric field intensity is determined.

[0075] For example, the effective induced electric field intensity can be represented by formula (7):

[0076] Formula (7);

[0077] Wherein, E is the effective induced electric field intensity, B is the second target intensity, is the second angle.

[0078] Wherein, B is determined by the number of turns of the coil and the current size, i.e., B=N·i, wherein N is the number of turns of the coil, and i is the current size of the coil.

[0079] For example, when the regulation area of the target object needs to be regulated (i.e., stimulated), the control module determines the first intensity and the second intensity corresponding to the regulation area based on the effective induced electric field intensity of the target object, wherein the first intensity is the intensity of the mechanical wave needed to be emitted to the regulation area, and the second intensity is the intensity of the magnetic field needed to be generated in the regulation area.

[0080] It should be noted that the stimulation of the movement area can be judged by observing the electromyographic signal to determine whether the stimulation is effective, and when stimulating the non-movement area, it is impossible to detect the electromyographic signal to determine whether the stimulation of the non-movement area is effective, so it is impossible to subjectively judge when the stimulation of the non-movement area is effective. Therefore, the present application mainly takes a non-movement area (such as the forehead area) of the brain of the target object as an example to explain how to determine the intensity of the mechanical wave and the intensity of the magnetic field corresponding to the non-movement area.

[0081] It should be noted that the above effective induced electric field intensity is the induced electric field intensity that the brain neuron can generate in response when stimulating the brain neuron of the target object; or in other words, when stimulating the brain neuron of the target object, if the intensity of the electric field generated by the brain neuron of the target object in this stimulation is greater than or equal to the effective induced electric field intensity, it means that this stimulation is effective. Therefore, the effective induced electric field intensity can be understood as the electric field intensity that can generate an effective response of the brain neuron of the target object.

[0082] Therefore, the application calculates the effective induced electric field intensity of the target object first, and then determines that the stimulation to the non-motion area of the target object is effective only when the electric field generated at least has the intensity of the effective induced electric field intensity. Then, the intensity of the electric field to be generated when the non-motion area of the target object is stimulated is determined in advance. Therefore, the effective induced electric field intensity can be used to inversely calculate how large the mechanical wave and the magnetic field need to be applied to the non-motion area to make the intensity of the electric field generated by the non-motion area reach the effective induced electric field intensity.

[0083] For example, the first angle between the emission direction of the mechanical wave emission module when emitting the mechanical wave to the regulation area and the magnetic field direction of the magnetic field generated by the magnetic field generation module in the regulation area is obtained, and the first distance between the mechanical wave emission module and the regulation area is obtained. The way of obtaining the first angle is similar to the way of obtaining the second angle, which will not be described again. The way of obtaining the first distance is similar to the way of obtaining the second distance, which will not be described again.

[0084] Then, the first intensity and the second intensity are determined based on the first angle, the first distance, the preset stimulation duration, and the effective induced electric field intensity.

[0085] For example, the correlation between the first intensity and the second intensity is determined based on the first angle, the first distance, the preset stimulation duration, the attenuation rate of the mechanical wave in the brain tissue, the density of the brain tissue, the propagation speed of the mechanical wave in the brain tissue, and the effective induced electric field intensity. The correlation is a relationship between the first intensity and the second intensity when the electric field with the intensity of the effective induced electric field intensity is generated in the regulation area.

[0086] Specifically, the first angle, the first distance, the preset stimulation duration, the attenuation rate of the mechanical wave in the brain tissue, the density of the brain tissue, the propagation speed of the mechanical wave in the brain tissue, and the effective induced electric field intensity are inversely substituted into the above formula (7), and then the correlation between the first intensity and the second intensity when the electric field with the intensity of the effective induced electric field intensity is generated at the first angle and the first distance can be determined, that is, the product of the first intensity and the second intensity belongs to a fixed value.

[0087] Finally, the control module determines the first intensity and the second intensity based on the correlation. Specifically, the product of the first intensity and the second intensity is a fixed value, and then any two values that satisfy the product relationship can be taken as the first intensity and the second intensity; or, based on the first value range corresponding to the magnetic field intensity and the second value range of the mechanical wave intensity, values that satisfy the product relationship are obtained in the first value range and the second value range, and such values are taken as the first intensity and the second intensity.

[0088] For example, the mechanical wave emitting module emits a mechanical wave with the first intensity to the regulation region. For example, the control module can send the first intensity to the mechanical wave emitting module, and then the mechanical wave emitting module can emit a mechanical wave with the first intensity to the regulation region along the first angle through the mechanical probe.

[0089] For example, the magnetic field generating module generates a magnetic field with the second intensity in the regulation region. Specifically, the magnetic field generating module generates a magnetic field through a coil. Therefore, after the second intensity is determined, a current value corresponding to the second intensity is determined based on the number of turns of the coil, and then a current with the current value is output to the coil, so as to generate a magnetic field with the second intensity.

[0090] It can be seen that in the embodiment of the present application, the brain regulation device includes a mechanical wave emitting module and a magnetic field generating module, so that the regulation region of the target object can be stimulated or regulated by the magnetic field and the mechanical wave at the same time, and when the regulation region of the target object is stimulated or regulated by the magnetic field and the mechanical wave at the same time, the control module of the brain regulation device determines the first intensity (i.e., the intensity of the mechanical wave) and the second intensity (i.e., the intensity of the magnetic field) corresponding to the regulation region based on the effective induced electric field intensity of the target object, i.e., the electric field intensity that can cause the brain neurons of the target object to produce an effective response, so as to determine the intensity matched with the target object, and then the mechanical wave emitting module emits a mechanical wave with the first intensity to the regulation region, and the magnetic field generating module generates a magnetic field with the second intensity in the regulation region, so as to produce an effective stimulation to the regulation region, i.e., to perform individualized regulation on the target object by using the matched intensity, thereby improving the treatment effect on the target object.

[0091] Referring to Figure 4 , Figure 4 A flowchart of a brain regulation method provided by an embodiment of the present application is shown. The method is applied to the brain regulation device described above. The method includes but is not limited to the following steps:

[0092] S401: Determine the first intensity and the second intensity corresponding to the regulation region of the target object based on the effective induced electric field intensity of the target object.

[0093] S402: transmit a mechanical wave with the first intensity to the regulation region.

[0094] S403: generate a magnetic field with the second intensity in the regulation region.

[0095] It should be noted that the specific implementation of S401-S403 can refer to the specific implementation process of the brain regulation device, and will not be described in detail here.

[0096] Referring to Figure 5 , Figure 5 A schematic diagram of an electronic device provided by an embodiment of the present application. The electronic device 500 can be the brain regulation device described above.

[0097] The electronic device 500 includes a memory 501, a processor 502, a communication interface 503, and a bus 504. The memory 501, the processor 502, and the communication interface 503 are communicatively connected to each other through the bus 504.

[0098] The memory 501 can be a read-only memory (ROM), a static storage device, a dynamic storage device, or a random access memory (RAM). The memory 501 can store a program; when the electronic device 500 is the brain regulation device described above, the processor 502 and the communication interface 503 are used to execute each step performed by the brain regulation device in the brain regulation method of the present application when the program stored in the memory 501 is executed by the processor 502.

[0099] The processor 502 can be a general-purpose central processing unit (CPU), a microprocessor, an application-specific integrated circuit (ASIC), a graphics processing unit (GPU), or one or more integrated circuits, which is used to execute related programs to implement the brain regulation method in the method embodiments of the present application.

[0100] The processor 502 can also be an integrated circuit chip having a processing capability for signals. In implementation, each step in the brain regulation method of the present application can be completed by integrated logic circuits of hardware in the processor 502 or instructions in the form of software. The processor 502 described above can also be a general processor, a digital signal processor (DSP), an application specific integrated circuit (ASIC), a field programmable gate array (FPGA) or other programmable logic device, a discrete gate or transistor logic device, a discrete hardware component. Each method, step and logic block diagram disclosed in the embodiments of the present application can be implemented or executed. The general processor can be a microprocessor or the processor can also be any conventional processor. The steps of the method disclosed in combination with the embodiments of the present application can be directly embodied as a hardware coding processor for execution, or a combination of hardware and software modules in the coding processor for execution. The software module can be located in a random access memory, a flash memory, a read only memory, a programmable read only memory or an electrically erasable programmable memory, a register or other mature storage medium in the art. The storage medium is located in the memory 501, and the processor 502 reads the information in the memory 501 to execute each step of the brain regulation method.

[0101] The communication interface 503 can be a transceiver device such as a transceiver to realize the communication between the electronic device 500 and other devices or communication networks; the communication interface 503 can also be an input-output interface to realize the data transmission between the electronic device 500 and input-output devices, wherein the input-output devices include but are not limited to keyboard, mouse, display screen, U disk and hard disk. For example, the processor 502 can receive signals through the communication interface 503.

[0102] The bus 504 can include a path for transmitting information between each component (for example, the memory 501, the processor 502, the communication interface 503) of the device electronic device 500.

[0103] It should be noted that although Figure 5 The electronic device 500 shown only shows the memory, processor, communication interface, but in the specific implementation process, those skilled in the art should understand that the electronic device 500 also includes other necessary devices for normal operation. At the same time, according to the specific needs, those skilled in the art should understand that the electronic device 500 can also include hardware devices for realizing other additional functions. In addition, those skilled in the art should understand that the electronic device 500 can also only include the necessary devices for realizing the embodiments of the present application, and does not have to include all the devices shown in the Figure 5

[0104] ​The embodiment of the present application further provides a computer readable storage medium, which stores a computer program. The computer program is executed by a processor to implement part or all of steps of any brain regulation method described in the above method embodiments.

[0105] The embodiment of the present application further provides a computer program product, which comprises a non-transitory computer readable storage medium storing a computer program. The computer program is operable to cause a computer to perform part or all of steps of any brain regulation method described in the above method embodiments.

[0106] It should be noted that, for the above-mentioned method embodiments, in order to simply describe, they are all expressed as a series of action combinations, but those skilled in the art should know that the present application is not limited to the action sequence described, because according to the present application, certain steps can be performed in other sequences or simultaneously. Secondly, those skilled in the art should know that the embodiments described in the specification all belong to optional embodiments, and the actions and modules involved are not necessarily required by the present application.

[0107] In the above embodiments, the description of each embodiment is focused on, and the part not described in detail in a certain embodiment can be referred to the related description of other embodiments.

[0108] In several embodiments provided in the present application, it should be understood that the disclosed device can be implemented by other means. For example, the device embodiments described above are only schematic, for example, the division of the units is only a logical function division, and actual implementation can have another division manner, for example, a plurality of units or components can be combined or integrated into another system, or some features can be ignored or not executed. In addition, the coupling or direct coupling or communication connection between the units shown or discussed can be indirect coupling or communication connection through some interface, device or unit, and can be electrical or other forms.

[0109] The units described as separate components can or can not be physically separate, and the components shown as units can or can not be physical units, that is, they can be located in one place, or can be distributed on a plurality of network units. Part or all of the units can be selected according to actual needs to achieve the purpose of the embodiment scheme.

[0110] In addition, each functional unit in each embodiment of the present application can be integrated in one processing unit, or each unit can be physically present separately, or two or more units can be integrated in one unit. The integrated unit can be realized in the form of hardware or in the form of software program module.

[0111] The integrated unit, if implemented in the form of a software program module and sold or used as an independent product, can be stored in a computer readable memory. Based on such understanding, the technical solutions of the present application essentially or the part of the prior art that contributes to the present application or the whole or part of the technical solutions can be embodied in the form of a software product. The computer software product is stored in a memory and includes a plurality of instructions for causing a computer device (which can be a personal computer, a server or a network device, etc.) to execute all or part of the steps of the method described in the various embodiments of the present application. The aforementioned memory includes: a U disk, a read-only memory (ROM), a random access memory (RAM), a mobile hard disk, a magnetic disk or an optical disk, and various media that can store program codes.

[0112] A person of ordinary skill in the art can understand that all or part of the steps in the above-mentioned various methods of the embodiments can be completed by a program instructing relevant hardware, and the program can be stored in a computer readable memory, which can include a flash disk, a read-only memory (ROM), a random access memory (RAM), a magnetic disk or an optical disk, etc.

[0113] The embodiments of the present application are described in detail above, and the principles and implementation manners of the present application are described by applying specific examples. The above description of the embodiments is only used to help understand the method of the present application and its core idea; meanwhile, for those of ordinary skill in the art, according to the idea of the present application, the specific implementation manner and application range will be changed, and the above description of the embodiments should not be understood as a limitation of the present application.

Claims

1. A brain modulation device, characterized in that, include: Control module, mechanical wave emitting module, magnetic field generating module; The effective induced electric field intensity of the target object is obtained by stimulating the motion area of ​​the target object in one or more rounds: during each stimulation process of the j-th round of stimulation, The mechanical wave emitting module is used to send intensity I to the moving area of ​​the target object. j Mechanical waves; The magnetic field generating module is used to generate intensity B in the motion region. j Magnetic field; The control module is used to control the intensity I each time. j Mechanical waves and intensity B j When the magnetic field stimulates the motor area, it is determined whether the peak-to-peak value of the electromyographic signal of the target object is greater than a first threshold, and the number of stimuli with peak-to-peak values ​​greater than the first threshold during the j-th round of stimulation is obtained; and, based on the number of stimuli and the total number of stimuli in the j-th round of stimulation, the proportion corresponding to the j-th round of stimulation is determined. If the proportion is less than the second threshold, then based on the I j The intensity I of the mechanical wave corresponding to the (j+1)th round of stimulation is obtained. j+1 and based on the intensity B j Determine the strength B of the magnetic field corresponding to the (j+1)th round of stimulation. j+1 In each stimulation process of the (j+1)th round of stimulation, intensity I is used j+1 Mechanical waves and intensity B j+1 The magnetic field stimulates the motion area to obtain the proportion corresponding to the (j+1)th round of stimulation, until the proportion is greater than or equal to the second threshold. If the proportion is greater than or equal to the second threshold, the effective induced electric field strength is determined based on the first target strength and the second target strength, wherein the first target strength is the strength of the mechanical wave emitted by the mechanical wave emitting module when the proportion is greater than or equal to the second threshold, and the second target strength is the strength of the magnetic field generated by the magnetic field generating module when the proportion is greater than or equal to the second threshold. The control module is used to determine the first intensity and the second intensity corresponding to the control region of the target object based on the effective induced electric field intensity of the target object; specifically, it is used for: Obtain a first angle between the direction in which the mechanical wave emitting module emits the mechanical wave into the control area and the direction in which the magnetic field generating module generates the magnetic field in the control area; obtain a first distance between the mechanical wave emitting module and the control area; Based on the first angle, the first distance, the preset stimulation duration, and the effective induced electric field strength, the first intensity and the second intensity are determined; The mechanical wave transmitting module is used to transmit a mechanical wave with an intensity of the first intensity into the control area; The magnetic field generating module is used to generate a magnetic field with the second intensity in the control region.

2. The device according to claim 1, characterized in that, In determining the first intensity and the second intensity based on the first angle, the first distance, the preset stimulation duration, and the effective induced electric field intensity, the control module is specifically used for: Based on the first angle, the first distance, the preset stimulation duration, the attenuation rate of the mechanical wave in the brain tissue, the density of the brain tissue, the propagation speed of the mechanical wave in the brain tissue, and the effective induced electric field strength, a correlation is determined, wherein the correlation is the relationship between the intensity of the mechanical wave and the intensity of the magnetic field when an electric field with an intensity equal to the effective induced electric field strength is generated in the control region. Based on the aforementioned correlation, the first strength and the second strength are determined.

3. The device according to claim 1, characterized in that, In determining the effective induced electric field strength based on the first target intensity and the second target intensity, the control module is specifically used for: Obtain a second angle between the direction of the mechanical wave emitted by the mechanical wave emitting module and the direction of the magnetic field generated by the magnetic field generating module; Obtain the second distance between the mechanical wave emitting module and the motion area; The effective induced electric field strength is determined based on the second angle, the second distance, the first target intensity, and the second target intensity.

4. The device according to claim 3, characterized in that, In determining the effective induced electric field strength based on the second angle, the second distance, the first target intensity, and the second target intensity, the control module is specifically used for: The cutting speed of the brain tissue is determined based on the first target intensity, the second distance, the attenuation rate of the mechanical wave in the brain tissue, and the propagation speed of the mechanical wave in the brain tissue. Based on the cutting speed and the preset stimulation duration, the effective cutting distance of the brain tissue in the magnetic field of the second target strength is determined; The effective induced electric field strength is determined based on the second target intensity, the effective cutting distance, the cutting speed, and the second angle.

5. The device according to claim 4, characterized in that, In determining the cutting speed of brain tissue based on the first target intensity, the second distance, the attenuation rate of the mechanical wave in brain tissue, and the propagation speed of the mechanical wave in brain tissue, the control module is specifically used for: Based on the first target intensity, the second distance, and the attenuation rate of the mechanical wave in brain tissue, a third intensity is determined for the mechanical wave of the first target intensity to reach the motor region. Based on the third intensity, the density of brain tissue, and the propagation speed of mechanical waves in brain tissue, the pressure value generated by the mechanical wave of the third intensity in the motor region is determined. The impedance of brain tissue is determined based on the density and the propagation speed; The cutting speed is determined based on the pressure value and the impedance.

6. An electronic device, characterized in that, The electronic device is used to implement the steps performed by the brain modulation device according to any one of claims 1-5, the electronic device comprising: a processor and a memory, the processor being connected to the memory, the memory being used to store a computer program, and the processor being used to execute the computer program stored in the memory, so that the electronic device performs the following steps: By stimulating the motion region of the target object in one or more rounds, the effective induced electric field intensity of the target object is obtained: during each stimulation process of the j-th round of stimulation, an intensity I is sent to the motion region of the target object. j Mechanical waves; generating intensity B in the region of motion. j Magnetic field; In each pass of intensity I j Mechanical waves and intensity B j When the magnetic field stimulates the motor area, it is determined whether the peak-to-peak value of the electromyographic signal of the target object is greater than a first threshold, and the number of stimuli with peak-to-peak values ​​greater than the first threshold during the j-th round of stimulation is obtained; and, based on the number of stimuli and the total number of stimuli in the j-th round of stimulation, the proportion corresponding to the j-th round of stimulation is determined. If the proportion is less than the second threshold, then based on the I j The intensity I of the mechanical wave corresponding to the (j+1)th round of stimulation is obtained. j+1 and based on the intensity B j Determine the strength B of the magnetic field corresponding to the (j+1)th round of stimulation. j+1 In each stimulation process of the (j+1)th round of stimulation, intensity I is used j+1 Mechanical waves and intensity B j+1 The magnetic field stimulates the motion area to obtain the proportion corresponding to the (j+1)th round of stimulation, until the proportion is greater than or equal to the second threshold. If the proportion is greater than or equal to the second threshold, the effective induced electric field strength is determined based on the first target strength and the second target strength, wherein the first target strength is the strength of the mechanical wave emitted by the mechanical wave emitting module when the proportion is greater than or equal to the second threshold, and the second target strength is the strength of the magnetic field generated by the magnetic field generating module when the proportion is greater than or equal to the second threshold. Based on the effective induced electric field strength of the target object, determine the first intensity and the second intensity corresponding to the control region of the target object, including: Obtain a first angle between the direction of the mechanical wave emitted by the mechanical wave emission module toward the control area and the direction of the magnetic field generated by the magnetic field generation module in the control area; obtain a first distance between the mechanical wave emission module and the control area; and determine the first intensity and the second intensity based on the first angle, the first distance, the preset stimulation duration, and the effective induced electric field intensity. A mechanical wave with the first intensity is emitted into the control region; A magnetic field with the second strength is generated in the controlled region.

7. A computer-readable storage medium, characterized in that, The computer-readable storage medium is used to implement the steps performed by the brain modulation device according to any one of claims 1-5, wherein the computer-readable storage medium stores a computer program that is executed by a processor to implement the following steps: By stimulating the motion region of the target object in one or more rounds, the effective induced electric field strength of the target object is obtained: during each stimulation process of the j-th round of stimulation, a mechanical wave of intensity Ij is sent to the motion region of the target object; a magnetic field of intensity Bj is generated in the motion region; Each time the motor region is stimulated by a mechanical wave of intensity Ij and a magnetic field of intensity Bj, it is determined whether the peak-to-peak value of the electromyographic signal of the target object is greater than a first threshold, and the number of stimuli with peak-to-peak values ​​greater than the first threshold during the j-th round of stimulation is obtained; and, based on the number of stimuli and the total number of stimuli in the j-th round of stimulation, the proportion corresponding to the j-th round of stimulation is determined. If the proportion is less than the second threshold, then based on Ij, the intensity Ij+1 of the mechanical wave corresponding to the (j+1)th round of stimulation is obtained, and based on the intensity Bj, the intensity Bj+1 of the magnetic field corresponding to the (j+1)th round of stimulation is determined, so that in each stimulation process of the (j+1)th round of stimulation, the motion area is stimulated with the mechanical wave of intensity Ij+1 and the magnetic field of intensity Bj+1 to obtain the proportion corresponding to the (j+1)th round of stimulation, until the proportion is greater than or equal to the second threshold; If the proportion is greater than or equal to the second threshold, the effective induced electric field strength is determined based on the first target strength and the second target strength, wherein the first target strength is the strength of the mechanical wave emitted by the mechanical wave emitting module when the proportion is greater than or equal to the second threshold, and the second target strength is the strength of the magnetic field generated by the magnetic field generating module when the proportion is greater than or equal to the second threshold. Based on the effective induced electric field strength of the target object, determine the first intensity and the second intensity corresponding to the control region of the target object, including: Obtain a first angle between the direction of the mechanical wave emitted by the mechanical wave emission module toward the control area and the direction of the magnetic field generated by the magnetic field generation module in the control area; obtain a first distance between the mechanical wave emission module and the control area; and determine the first intensity and the second intensity based on the first angle, the first distance, the preset stimulation duration, and the effective induced electric field intensity. A mechanical wave with the first intensity is emitted into the control region; A magnetic field with the second strength is generated in the controlled region.

8. A computer program product, characterized in that, The computer program product is used to implement the steps performed by the brain modulation device according to any one of claims 1-5, the computer program product comprising a computer program that, when executed by a processor, performs the following steps: By stimulating the motion region of the target object in one or more rounds, the effective induced electric field strength of the target object is obtained: during each stimulation process of the j-th round of stimulation, a mechanical wave of intensity Ij is sent to the motion region of the target object; a magnetic field of intensity Bj is generated in the motion region; Each time the motor region is stimulated by a mechanical wave of intensity Ij and a magnetic field of intensity Bj, it is determined whether the peak-to-peak value of the electromyographic signal of the target object is greater than a first threshold, and the number of stimuli with peak-to-peak values ​​greater than the first threshold during the j-th round of stimulation is obtained; and, based on the number of stimuli and the total number of stimuli in the j-th round of stimulation, the proportion corresponding to the j-th round of stimulation is determined. If the proportion is less than the second threshold, then based on Ij, the intensity Ij+1 of the mechanical wave corresponding to the (j+1)th round of stimulation is obtained, and based on the intensity Bj, the intensity Bj+1 of the magnetic field corresponding to the (j+1)th round of stimulation is determined, so that in each stimulation process of the (j+1)th round of stimulation, the motion area is stimulated with the mechanical wave of intensity Ij+1 and the magnetic field of intensity Bj+1 to obtain the proportion corresponding to the (j+1)th round of stimulation, until the proportion is greater than or equal to the second threshold; If the proportion is greater than or equal to the second threshold, the effective induced electric field strength is determined based on the first target strength and the second target strength, wherein the first target strength is the strength of the mechanical wave emitted by the mechanical wave emitting module when the proportion is greater than or equal to the second threshold, and the second target strength is the strength of the magnetic field generated by the magnetic field generating module when the proportion is greater than or equal to the second threshold. Based on the effective induced electric field strength of the target object, determine the first intensity and the second intensity corresponding to the control region of the target object, including: Obtain a first angle between the direction of the mechanical wave emitted by the mechanical wave emission module toward the control area and the direction of the magnetic field generated by the magnetic field generation module in the control area; obtain a first distance between the mechanical wave emission module and the control area; and determine the first intensity and the second intensity based on the first angle, the first distance, the preset stimulation duration, and the effective induced electric field intensity. A mechanical wave with the first intensity is emitted into the control region; A magnetic field with the second strength is generated in the controlled region.

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