Non-irritant multipurpose long-acting degerming liquid

Abstract

The invention discloses a non-irritant multipurpose long-acting degerming liquid, which is prepared from the following ingredients in percentage by mass: 0.1 to 0.5 percent of cationic polymer antibacterial agents, 1 to 4 percent of quaternary ammonium salt surfactants A, 0.5 to 2 percent of quaternary ammonium salt surfactants B, 1.5 to 5 percent of polyhydric alcohol humectants, 0.1 to 2 percent of alcohol solvents, 0.3 to 1 percent of plant natural polyphenols and 0.5 to 2 percent of optional essence. And the balance of deionized water. Wherein the cationic polymer antibacterial agent is preferably selected from polyhexamethylene biguanide hydrochloride (PHMB), and the quaternary ammonium salt surfactant is preferably selected from dodecyl dimethyl benzyl ammonium chloride (DDBAC) and tetradecyl dimethyl benzyl ammonium chloride (TDBAC). The benzalkonium chloride and the PHMB biguanide system are perfectly combined, efficient sterilization and disinfection are achieved, and meanwhile the long-acting antibacterial effect is achieved. The product contains natural plant components such as sugarcane essence, can effectively neutralize acidic peculiar smells such as sweat smell and foot odor, realizes zero irritation, and is especially suitable for people with sensitive skin and alcohol allergy.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of sterilization solution, in particular to a non-irritating multipurpose long-acting sterilization solution. BACKGROUND

[0002] Bacteria and viruses are the pathogens of many diseases, such as influenza virus, Escherichia coli, Staphylococcus aureus, etc. They can be transmitted through air, contact, droplets and other ways, causing various diseases and endangering human health. Sterilization solution can quickly and effectively kill these bacteria and viruses, reduce their number and activity in the environment, thereby reducing the risk of disease transmission and protecting people's health.

[0003] With the improvement of living standards, people's demand for living quality and hygiene is also increasing, and they pay more and more attention to the cleaning and sterilization of living space and various objects to prevent the spread of diseases. Sterilization solution can help people better maintain the cleanliness and hygiene of the living environment, reduce the breeding of bacteria and viruses, and prevent the occurrence of diseases, thereby improving people's living quality. At the same time, the use of sterilization solution can also cultivate people's hygiene awareness and make people pay more attention to personal and environmental hygiene and develop good hygiene habits. In addition, in places with high population density such as schools, shopping malls, stations, etc., sterilization solution can be used for disinfection to effectively reduce the spread of bacteria and viruses and prevent the outbreak of infectious diseases.

[0004] Different scenarios have different requirements for cleaning and disinfection, and the development of sterilization solution can provide effective solutions for these specific needs. For example, in medical settings, high-efficiency and broad-spectrum sterilization solution is needed to disinfect surgical instruments, hospital environments, etc. to ensure medical safety; in the food processing industry, sterilization solution that meets food safety standards is needed to disinfect processing equipment, packaging materials, etc. to prevent bacterial contamination of food; in the home, people hope to have mild and non-irritating sterilization solution to clean clothes, tableware, floors, and household surfaces, etc. to reduce the breeding of bacteria and viruses and create a healthy living environment for family members to protect their health.

[0005] The continuous progress of science and technology provides support for the development of sterilization solution. On the one hand, the development of analytical detection technology enables people to more accurately detect the sterilization effect and safety of sterilization solution; on the other hand, the development of material science, chemical synthesis technology, etc. enables researchers to develop more efficient sterilization ingredients and more stable formulations.

[0006] Modern society attaches increasing importance to environmental protection and safety, which also affects the direction of sterilization solution research and development. Researchers need to find more natural, environmentally friendly, non-irritating, non-toxic, and residue-free sterilization ingredients and formulations to meet people's dual demands for health and environmental protection.

[0007] Benzalkonium chloride solution is a quaternary ammonium cationic surfactant, which is a fast broad-spectrum bactericide with moderate bactericidal intensity. It can quickly destroy the cell membrane of microorganisms, leading to their death. Low concentration has bactericidal effect on various gram-positive and gram-negative bacteria, has certain antifungal effect, and is effective against some viruses. Benzalkonium chloride is more sensitive to gram-positive bacteria, but requires higher concentration for gram-negative bacteria, and is ineffective against spores, tubercle bacillus and pseudomonas aeruginosa. In addition, benzalkonium chloride is easily affected by organic matter and pH, and its bactericidal effect will be significantly reduced in the presence of organic matter such as blood, cotton and cellulose; the antibacterial activity is best in neutral to weak alkaline environment, and the bactericidal effect will be significantly reduced in acidic environment. And high concentration may cause irritation to the skin and mucous membrane, and even cause allergic reactions such as skin rash and itching.

[0008] Polyhexamethylene biguanide hydrochloride (PHMB) is a highly effective cationic polymer antibacterial agent that works by changing the permeability of bacterial cell membranes, with broad-spectrum antibacterial properties. It has good killing effect on gram-positive bacteria such as staphylococcus aureus, streptococcus, and gram-negative bacteria such as escherichia coli and pseudomonas aeruginosa, has certain antifungal effect, and is effective against some viruses. However, compared with some traditional disinfectants, the production cost of PHMB is higher.

[0009] Chinese invention patent CN116196455A discloses an environmental bacteriostatic deodorant and its preparation method, which comprises benzalkonium chloride, polyhexamethylene biguanide hydrochloride, zinc oleate, plant fermentation liquid, defoaming agent, coagulant, and the rest is deionized water. The high-efficiency deodorant plant fermentation liquid removes odor, replacing the traditional method of masking environmental bacteriostatic odor with fragrance; plant extraction is non-toxic and harmless, and polyhexamethylene biguanide hydrochloride can effectively disinfect and sterilize, which is environmentally friendly. However, the patent does not provide any data on bactericidal effect and deodorizing effect, and cannot prove its actual effect and determine its irritation to the human body.

[0010] Therefore, the applicant hopes to compound benzalkonium chloride and polyhexamethylene biguanide hydrochloride to reduce costs while obtaining a long-acting bactericidal solution that is efficient, non-irritating and highly bactericidal. SUMMARY

[0011] To solve the above problems, the present application provides a non-irritating multipurpose long-acting bactericidal solution.

[0012] To achieve the above purpose, the technical scheme adopted by the present application is: The application provides a non-irritating multipurpose long-acting disinfectant solution, characterized by comprising: 0.1-0.5% of a cationic polymer antiseptic, 1-4% of a quaternary ammonium salt surfactant A, 0.5-2% of a quaternary ammonium salt surfactant B, 1.5-5% of a polyol humectant, 0.1-2% of an alcohol solvent, 0.3-1% of a plant natural polyphenol, and the rest being deionized water.

[0013] Further, the non-irritating multipurpose long-acting disinfectant solution further comprises 0.5-2% of essence.

[0014] Further, the cationic polymer antiseptic is polyhexamethylene biguanide hydrochloride PHMB, polyethyleneimine PEI, chlorhexidine gluconate CHG or polyaminopropyl biguanide PAPB.

[0015] Further, the quaternary ammonium salt surfactant A is dodecyl dimethyl benzyl ammonium chloride DDBAC, benzalkonium chloride BAC, dipauryl dimethyl ammonium chloride DDAC, cetyl trimethyl ammonium chloride CTAC or cetylpyridinium chloride CPC.

[0016] Further, the quaternary ammonium salt surfactant B is tetradecyl dimethyl benzyl ammonium chloride TDBAC or dodecyl dimethyl benzyl ammonium chloride DDBAC.

[0017] Further, the polyol humectant is 1,2-propanediol, glycerol, butanediol, hexanediol or pentanediol.

[0018] Further, the alcohol solvent is ethanol, isopropyl alcohol or butanol.

[0019] Further, the plant natural polyphenol is sugarcane polyphenol, tea polyphenol, grape seed extract, dipotassium glycyrrhizinate or olive polyphenol.

[0020] Preferably, the non-irritating multipurpose long-acting disinfectant solution comprises, by mass percentage: 0.15-0.3% of polyhexamethylene biguanide hydrochloride, 2-3% of dodecyl dimethyl benzyl ammonium chloride, 0.7-1.5% of tetradecyl dimethyl benzyl ammonium chloride, 2-3.5% of 1,2-propanediol, 0.15-1% of ethanol, 0.35-0.8% of sugarcane polyphenol, and the rest being deionized water.

[0021] Preferably, the non-irritating multipurpose long-acting disinfectant solution comprises, by mass percentage: 0.18%-0.25% of polyhexamethylene biguanide hydrochloride, 2.2%-2.8% of dodecyl dimethyl benzyl ammonium chloride, 0.8%-1.2% of tetradecyl dimethyl benzyl ammonium chloride, 2.2%-3% of 1,2-propanediol, 0.2%-0.5% of ethanol, 0.4%-0.6% of sugarcane polyphenol, 0.7%-1.5% of essence, and the rest is deionized water.

[0022] Compared with the prior art, the present application has the following beneficial effects: 1. Broad-spectrum and high-efficiency bacteriostatic effect: The non-irritating multipurpose long-acting disinfectant solution provided by the present application has a 99% disinfection and antibacterial effect, and can kill (inhibit) Staphylococcus aureus, Escherichia coli, Candida albicans, and Red Hair Moss.

[0023] 2. Long-acting bacteriostatic effect: The non-irritating multipurpose long-acting disinfectant solution provided by the present application can achieve persistent whole-body health protection with sustained antibacterial effect. The disinfectant solution is stable in nature and has a shelf life of 2 years. After being sprayed or applied on the surface of an object, the disinfectant effect lasts for more than 3 months (tested in Japan) and is expected to last for more than 1 year without contact with water.

[0024] 3. Deodorizing function: The plant natural polyphenol component contained in the present application, such as sugarcane polyphenol, has the effect of non-volatilization, neutralization and decomposition of malodors, and its aromatic components can effectively mask malodors. It can effectively decompose the odor caused by ammonia, acetic acid and other components (such as excrement, sweat, etc.) 4. Non-irritating to human body: The non-irritating multipurpose long-acting disinfectant solution provided by the present application has a stimulation index of 0.00 after multiple skin irritation tests; the stimulation index is <1 after multiple vaginal mucosa irritation tests, which is non-irritating. The acute oral toxicity test shows that it is actually non-toxic. The skin allergy test shows that the skin sensitization rate is 0.00% and the sensitization intensity is no skin allergy. It is proved that the disinfectant solution of the present application is non-irritating, safe and can be used with confidence.

[0025] 5. Wide application: The non-irritating multipurpose long-acting disinfectant solution provided by the present application can be used for bacteriostatic and disinfectant in various occasions, and can be applied to bare skin, personal furniture, shoe and clothing surface, car interior (except for leather articles), school and office disinfection and sterilization, and has good application prospect. BRIEF DESCRIPTION OF DRAWINGS

[0026] The accompanying drawings are used to provide a further understanding of the present application, and constitute a part of the specification, together with the embodiments of the present application, to explain the present application, and do not constitute a limitation of the present application.

[0027] In the drawings: Figure 1 Report on the sterilization effect of the sterilizing solution of the present application on Escherichia coli; Figure 2 Report on the sterilization effect of the sterilizing solution of the present application on Staphylococcus aureus; Figure 3 Report on the sterilization effect of the sterilizing solution of the present application on Candida albicans; Figure 4 Report on the stability of the sterilizing solution of the present application; Figure 5 Report on the skin irritation test of the sterilizing solution of the present application; Figure 6 Report on the vaginal mucosa irritation test of the sterilizing solution of the present application; Figure 7 Report on the acute oral toxicity test of the sterilizing solution of the present application; Figure 8 Report on the skin allergy test of the sterilizing solution of the present application. DETAILED DESCRIPTION

[0028] The present application will be further described below.

[0029] Due to the different sterilization effects and irritations of single-component sterilizing agents at different concentrations, for example, benzalkonium chloride has certain irritation to the human body when its concentration exceeds 1000 ppm, the present application adds polyhexamethylene biguanide hydrochloride PHMB in the formula, so that both effective components are within the safe range, and the sterilization effect that single-component cannot achieve can be achieved.

[0030] The present application provides a non-irritating multipurpose long-acting sterilizing solution, which is a composite broad-spectrum antibacterial and bacteriostatic solution, and the main active and auxiliary components are analyzed as follows: Polyhexamethylene biguanide hydrochloride: long-acting antibacterial, low irritation, can destroy bacterial DNA and cell membrane, and residual sustained release.

[0031] Dodecyl dimethyl benzyl ammonium chloride: strong surface activity, has significant bacteriostatic effect on gram-positive and gram-negative bacteria.

[0032] Myristyl dimethyl benzyl ammonium chloride: strong liposolubility, increases surface adhesion and durability.

[0033] 1,2-propanediol: humectant and solvent, also has bacteriostatic synergistic effect.

[0034] Ethanol: fast sterilization, auxiliary dissolution and volatilization.

[0035] Sugarcane polyphenol: natural antioxidant, with certain antibacterial ability and neutralization of odor.

[0036] Pure water: carrier and diluent.

[0037] The non-irritating multipurpose long-acting disinfectant solution provided by the present application is mainly aimed at the following bacterial groups: Escherichia coli (causing various inflammations), Staphylococcus aureus (the culprit of beriberi), Bacillus cereus (causing food poisoning), Salmonella enterica (causing acute enteritis and other conditions), Serratia marcescens (causing respiratory tract infections), Legionnaires' disease (causing pneumonia), and the like, and has a broad-spectrum, high-efficiency and long-lasting bacteriostatic and bactericidal effect.

[0038] Several specific embodiments of the present application are given below. Embodiment

[0039] A non-irritating multipurpose long-acting disinfectant solution, by mass percentage, contains: 0.2% of polyhexamethylene biguanide hydrochloride, 2.6% of dodecyl dimethyl benzyl ammonium chloride, 1% of tetradecyl dimethyl benzyl ammonium chloride, 2.4% of 1,2-propanediol, 0.3% of ethanol, 0.5% of sugarcane polyphenol, 1% of essence, and the rest is pure water. Embodiment

[0040] A non-irritating multipurpose long-acting disinfectant solution, by mass percentage, contains: 0.18% of polyhexamethylene biguanide hydrochloride, 2.8% of dodecyl dimethyl benzyl ammonium chloride, 0.8% of tetradecyl dimethyl benzyl ammonium chloride, 2.2% of 1,2-propanediol, 0.4% of ethanol, 0.6% of sugarcane polyphenol, and the rest is pure water. Embodiment

[0041] A non-irritating multipurpose long-acting disinfectant solution, by mass percentage, contains: 0.15% of polyhexamethylene biguanide hydrochloride, 2% of dodecyl dimethyl benzyl ammonium chloride, 1.5% of tetradecyl dimethyl benzyl ammonium chloride, 3% of 1,2-propanediol, 0.5% of ethanol, 0.35% of tea polyphenol, and the rest is deionized water. Embodiment

[0042] A non-irritating multipurpose long-acting disinfectant solution, by mass percentage, contains: 0.1% of polyhexamethylene biguanide hydrochloride, 2.2% of dodecyl dimethyl benzyl ammonium chloride, 1.2% of tetradecyl dimethyl benzyl ammonium chloride, 2% of 1,2-propanediol, 0.15% of isopropyl alcohol, 0.8% of sugarcane polyphenol, 1.5% of essence, and the rest is deionized water. Embodiment

[0043] The non-irritating multipurpose long-acting disinfectant solution comprises, by mass percentage, 0.25% of polyethyleneimine, 3% of cetylpyridinium chloride, 2% of tetradecyldimethylbenzylammonium chloride, 3.5% of glycerol, 1% of ethanol, 0.4% of tea polyphenol, 1.2% of essence, and the rest is deionized water. Embodiment

[0044] The non-irritating multipurpose long-acting disinfectant solution comprises, by mass percentage, 0.3% of chlorhexidine gluconate, 4% of cetyltrimethylammonium chloride, 0.5% of dodecyldimethylbenzylammonium chloride, 4% of butanediol, 2% of butanol, 0.3% of grape seed extract, 0.8% of essence, and the rest is deionized water. Embodiment

[0045] The non-irritating multipurpose long-acting disinfectant solution comprises, by mass percentage, 0.4% of polyhexamethylene biguanide hydrochloride, 3.5% of dipentaerythritol dimethyl ammonium chloride, 1.8% of tetradecyldimethylbenzylammonium chloride, 1.5% of hexanediol, 0.1% of ethanol, 1% of dipotassium glycyrrhizinate, 2% of essence, and the rest is deionized water. Embodiment

[0046] The non-irritating multipurpose long-acting disinfectant solution comprises, by mass percentage, 0.5% of polyaminopropyl biguanide, 1% of benzalkonium chloride, 0.7% of dodecyldimethylbenzylammonium chloride, 5% of pentanediol, 0.2% of ethanol, 0.7% of olive polyphenol, 0.5% of essence, and the rest is deionized water.

[0047] The samples in embodiments 1-2 are sent to a detection agency for sample detection, and the results are as follows: Figure 1 It is a report on the bactericidal effect of the disinfectant solution of the application on escherichia coli; Figure 2 It is a report on the bactericidal effect of the disinfectant solution of the application on staphylococcus aureus; Figure 3 It is a report on the bactericidal effect of the disinfectant solution of the application on candida albicans; Figure 4 It is a report on the stability of the disinfectant solution of the application; Figure 5 It is a report on the skin irritation test of the disinfectant solution of the application; Figure 6 It is a report on the vaginal mucosa irritation test of the disinfectant solution of the application; Figure 7 It is a report on the acute oral toxicity test of the disinfectant solution of the application; Figure 8Skin allergy test report of the sterilization solution of the present application.

[0048] As can be seen from Figures 1-8 The sterilization solution of the present application has a high bacteriostatic effect of more than 99%. The product has good stability, has a long-lasting bacteriostatic and sterilization effect, and is non-irritating to the human body, so it can be used safely.

[0049] The long-acting antibacterial mechanism of the sterilization solution of the present application cannot currently provide test reports and data, but it is as follows: 1. Polyhexamethylene biguanide hydrochloride PHMB: - High molecular structure, can be adsorbed on the surface of the object, slowly release antibacterial components.

[0050] - Literature shows that its efficacy can last for more than 30-90 days under dry or closed conditions.

[0051] 2. Double quaternary ammonium salt (dodecyl dimethyl benzyl ammonium chloride and tetradecyl dimethyl benzyl ammonium chloride): - Strong surface adsorption capacity, broad antibacterial spectrum.

[0052] - After pairing with aliphatic chain double quaternary ammonium salt, the theoretical residual effect can be extended to more than 30 days.

[0053] 3. Synergistic system: - Polyhexamethylene biguanide hydrochloride PHMB and quaternary ammonium salt have a synergistic antibacterial mechanism, enhancing the inhibition of various microorganisms.

[0054] - 1,2-propanediol, sugarcane polyphenol, etc. enhance stability and broad-spectrum.

[0055] The theoretical persistence period analysis (environmental dependence) obtained by combining the broad spectrum is as follows: Use scenarios: - Medical device surface: ≥90 days - Household surface spraying: 30-60 days - Skin contact use: 24-72 hours - Plastic packaging storage: ≥12 months Note: The duration is affected by factors such as environmental temperature, humidity, and light.

[0056] In summary, the following conclusions can be drawn: The formula of the present application is based on a highly synergistic broad-spectrum antibacterial system, and the main components PHMB and double quaternary ammonium salt have a significant and long-lasting bacteriostatic effect. In theoretical analysis, it can maintain antibacterial ability for more than 3 months in a dry environment.

[0057] The application perfectly combines benzalkonium chloride and PHMB biguanide system, realizes efficient sterilization and disinfection, and has long-acting bacteriostatic effect at the same time. The product contains natural plant ingredients such as sugarcane essence, can effectively neutralize acidic peculiar smell such as sweat smell and foot odor, and brings fresh and comfortable experience.

[0058] The application adopts internationally certified non-irritating bactericidal and antibacterial cosmetic raw materials, compared with alcohol and hypochlorous acid products, the product emits light and elegant fragrance, realizes zero irritation. The texture is like water, especially suitable for sensitive skin and alcohol allergy, gently protects every inch of skin.

[0059] The above is a further detailed description of the application made in combination with the specific embodiments, which cannot be considered as limiting the specific implementation of the application; for the skilled in the art and related technical field, the expansion, operation method and data replacement made on the basis of the technical solution idea of the application should fall within the protection scope of the application.

Claims

1. A non-irritating, multi-purpose, long-lasting disinfectant, characterized in that: By weight percentage, it contains: 0.1%~0.5% cationic polymer antibacterial agent, 1%~4% quaternary ammonium salt surfactant A, 0.5%~2% quaternary ammonium salt surfactant B, 1.5%~5% polyol moisturizer, 0.1%~2% alcohol solvent, 0.3%~1% plant natural polyphenols, and the remainder is deionized water.

2. The non-irritating, multi-purpose, long-lasting disinfectant solution according to claim 1, characterized in that: It also contains 0.5% to 2% fragrance by weight.

3. The non-irritating, multi-purpose, long-lasting disinfectant solution according to claim 1, characterized in that: The cationic polymer antibacterial agent is polyhexamethylene biguanide hydrochloride (PHMB), polyethyleneimine (PEI), chlorhexidine gluconate (CHG), or polyaminopropyl biguanide (PAPB).

4. The non-irritating, multi-purpose, long-lasting disinfectant solution according to claim 1, characterized in that: The quaternary ammonium salt surfactant A is dodecyl dimethyl benzyl ammonium chloride DDBAC, benzalkonium chloride BAC, dicedyl dimethyl ammonium chloride DDAC, hexadecyl trimethyl ammonium chloride CTAC, or hexadecylpyridine chloride CPC.

5. The non-irritating, multi-purpose, long-lasting disinfectant solution according to claim 1, characterized in that: The quaternary ammonium salt surfactant B is tetradecyl dimethyl benzyl ammonium chloride (TDBAC) or dodecyl dimethyl benzyl ammonium chloride (DDBAC).

6. The non-irritating, multi-purpose, long-lasting disinfectant solution according to claim 1, characterized in that: The polyol moisturizer is 1,2-propanediol, glycerin, butylene glycol, hexanediol, or pentanediol.

7. The non-irritating, multi-purpose, long-lasting disinfectant solution according to claim 1, characterized in that: The alcohol solvent is ethanol, isopropanol, or butanol.

8. The non-irritating, multi-purpose, long-lasting disinfectant solution according to claim 1, characterized in that: The plant-derived natural polyphenols are sugarcane polyphenols, tea polyphenols, grape seed extract, dipotassium glycyrrhizate, or olive polyphenols.

9. The non-irritating, multi-purpose, long-lasting disinfectant solution according to claim 1 or 2, characterized in that, By weight percentage, it contains: 0.15%~0.3% polyhexamethylene biguanide hydrochloride, 2%~3% dodecyl dimethyl benzyl ammonium chloride, 0.7%~1.5% tetradecyl dimethyl benzyl ammonium chloride, 2%~3.5% 1,2-propanediol, 0.15%~1% ethanol, 0.35%~0.8% sugarcane polyphenols, with the remainder being deionized water.

10. The non-irritating, multi-purpose, long-lasting disinfectant solution according to claim 9, characterized in that, By weight percentage, it contains: 0.18%~0.25% polyhexamethylene biguanide hydrochloride, 2.2%~2.8% dodecyl dimethyl benzyl ammonium chloride, 0.8%~1.2% tetradecyl dimethyl benzyl ammonium chloride, 2.2%~3% 1,2-propanediol, 0.2%~0.5% ethanol, 0.4%~0.6% sugarcane polyphenols, 0.7%~1.5% flavoring, and the remainder is deionized water.

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