A percutaneous interventional breathing assistance system and working method

Abstract

The present application relates to the technical field of medical devices, in particular to a percutaneous interventional breathing assistance system and working method. The breathing assistance system comprises an oxygenation ultrafiltration system, a catheter system and a power system. The oxygenation ultrafiltration system comprises an oxygenation device, an ultrafiltration device and an oxygen supply device. The oxygenation device has a central cavity, an oxygenation cavity and a constant-temperature ultrafiltration cavity. The oxygenation cavity and the constant-temperature ultrafiltration cavity are provided with an oxygenation membrane filament layer and a blood ultrafiltration membrane, respectively. The oxygen supply device is connected to both ends of the oxygenation membrane filament layer, and the ultrafiltration device is connected to the constant-temperature ultrafiltration cavity. The catheter system is connected to the central cavity and the constant-temperature ultrafiltration cavity. The power system provides the power for blood flow. The present application can improve blood oxygen saturation, realize blood filtration, electrolyte regulation and temperature control, and fill the treatment gap between traditional oxygen inhalation, breathing machines and full-function extracorporeal membrane oxygenation.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical devices, in particular to a percutaneous interventional respiratory assistance system and a working method. BACKGROUND

[0002] Respiratory insufficiency is a serious respiratory disease, and common treatment methods include catheter oxygen inhalation, breathing machine mechanical ventilation and extracorporeal membrane oxygenation. Among them, the treatment effect of oxygen inhalation and breathing machine depends largely on the lung function of the patient, and when the patient's respiratory function decreases significantly, the effect of improving the blood oxygen saturation of the patient is poor; extracorporeal membrane oxygenation can effectively improve the blood oxygen saturation of patients with respiratory insufficiency, but due to factors such as large device size, blood damage leading to coagulation-related complications, high price, etc., extracorporeal membrane oxygenation is often used for patients with severe respiratory failure.

[0003] Therefore, there is an urgent need for a respiratory assistance system between oxygen inhalation, breathing machine and extracorporeal membrane oxygenation to meet the treatment needs of patients with impaired respiratory function who do not need extracorporeal membrane oxygenation. SUMMARY

[0004] In view of the deficiencies of the prior art, the purpose of the embodiments of the present application is to provide a percutaneous interventional respiratory assistance system and a working method, which can cover the patient population with impaired respiratory function who do not need extracorporeal membrane oxygenation, improve blood oxygen saturation while realizing blood filtration, electrolyte regulation and temperature control, and ensure treatment safety and effectiveness.

[0005] In order to achieve the above-mentioned purpose, the embodiments of the present application provide the following technical solutions:

[0006] A percutaneous interventional respiratory assistance system, comprising an oxygenation ultrafiltration system, a catheter system and a power system; the oxygenation ultrafiltration system comprises an oxygenation device, an ultrafiltration device and an oxygen supply device, the oxygenation device has a central cavity, an oxygenation cavity and a constant-temperature ultrafiltration cavity distributed in turn along the radial direction outward, the central cavity and the oxygenation cavity have an oxygenation membrane filament layer therebetween, the oxygenation cavity and the constant-temperature ultrafiltration cavity have a blood ultrafiltration membrane therebetween, the oxygen supply device is connected to both ends of the oxygenation membrane filament layer, and the ultrafiltration device is connected to the constant-temperature ultrafiltration cavity; the catheter system connects patient venous blood with the central cavity and the constant-temperature ultrafiltration cavity with patient venous blood, and the power system is installed in the catheter system to provide blood flow power.

[0007] Optionally, the oxygenation device has a central tube, one end of the central tube is a blood inlet, the other end is sealed, the central tube is the central cavity, and a plurality of blood through slots are arranged in an array on the wall of the central tube, the blood through slots penetrate the wall of the central tube along the radial direction.

[0008] Optionally, the oxygenation device further comprises an inner clamping ring, the inner clamping ring is sleeved on both ends of the oxygenation membrane filament layer and fixes the oxygenation membrane filament layer on the central tube.

[0009] Optionally, the oxygenation device further comprises an inner sleeve, an outer clamping ring, an outer sleeve and a rear cover, one end of the inner sleeve is installed on the inner clamping ring and the other end is suspended, the outer clamping ring is sleeved on both ends of the blood ultrafiltration membrane and fixes the blood ultrafiltration membrane on the inner sleeve, the outer sleeve is installed on the outer clamping ring, the rear cover is located at the suspended end of the inner sleeve and is installed on the inner clamping ring and the outer clamping ring, the oxygenation cavity is surrounded by the outer side of the oxygenation membrane filament layer, the inner side of the inner sleeve and the rear cover, the oxygenation cavity is located at one end of the blood ultrafiltration membrane, and the constant-temperature ultrafiltration cavity is surrounded by the outer side of the blood ultrafiltration membrane and the inner side of the outer sleeve.

[0010] Optionally, the oxygenation device further comprises a front cover, the front cover is located at the non-suspended end of the inner sleeve and is installed on the inner clamping ring and the outer clamping ring, and a blood outlet is arranged on the front cover, the blood outlet is located at the other end of the blood ultrafiltration membrane.

[0011] Optionally, an oxygen inlet is arranged on the rear cover and an oxygen outlet is arranged on the front cover, the oxygen inlet and the oxygen outlet are located at both ends of the oxygenation membrane filament layer.

[0012] Optionally, the catheter system comprises a venous blood outlet catheter and a venous blood return catheter, the power system comprises a power blood pump, one end of the venous blood outlet catheter is connected to the venous blood of the patient, the other end is connected to the blood inlet of the central tube through the power blood pump, one end of the venous blood return catheter is connected to the blood outlet of the front cover, and the other end is connected to the venous blood of the patient.

[0013] Optionally, the monitoring device comprises a blood oxygen monitoring module installed on the venous blood outlet catheter and a blood oxygen monitoring module and a temperature monitoring module installed on the venous blood return catheter.

[0014] Optionally, the oxygenation ultrafiltration system further comprises a constant-temperature ultrafiltration device, the constant-temperature ultrafiltration device is in communication with the constant-temperature ultrafiltration liquid inlet and the constant-temperature ultrafiltration liquid outlet on the outer sleeve, and the ultrafiltration device is in communication with the constant-temperature ultrafiltration device.

[0015] The embodiment of the present application also provides a working method of the percutaneous interventional breathing assistance system, comprising the following steps:

[0016] The venous blood of the patient is introduced into the power system through the catheter, and the blood is transported to the oxygenation device under the pressure boosting action of the power system;

[0017] The blood passes through the oxygenation membrane filament layer in the oxygenation device, exchanges blood oxygen with the oxygen in the membrane filament, and improves the blood oxygen level of the blood;

[0018] The constant-temperature ultrafiltration system injects constant-temperature ultrafiltration liquid into the constant-temperature ultrafiltration cavity, and the oxygenated blood flows through the blood ultrafiltration membrane to filter microthrombus and blood waste, while electrolyte is adjusted, and the blood temperature is adjusted to the normal temperature range;

[0019] The processed blood is delivered back to the vein of the patient through the catheter.

[0020] The one or more technical solutions provided in the embodiments of the present application have at least the following technical effects or advantages:

[0021] The percutaneous intervention respiratory assistance system of the present application comprises an oxygenation ultrafiltration system, a catheter system and a power system. The oxygenation ultrafiltration system comprises an oxygenation device, an ultrafiltration device and an oxygen supply device. The oxygenation device adopts a radial layered design, and from inside to outside, it comprises a central cavity, an oxygenation cavity and a constant-temperature ultrafiltration cavity. The oxygenation membrane wire layer is between the central cavity and the oxygenation cavity. The oxygenation cavity and the constant-temperature ultrafiltration cavity are separated by a blood ultrafiltration membrane. The oxygen supply device is connected to both ends of the oxygenation membrane wire layer to provide oxygen. The ultrafiltration device is in communication with the constant-temperature ultrafiltration cavity. The catheter system guides the venous blood of the patient to the central cavity and delivers the processed blood from the constant-temperature ultrafiltration cavity back to the vein of the patient. The power system is integrated in the catheter system to provide power for the blood flow. The system integrates the oxygenation and ultrafiltration functions in a compact device and adopts a percutaneous intervention method, which is suitable for patients with impaired lung function but not yet reaching the degree of having to use extracorporeal membrane oxygenation. Through the integrated oxygenation and ultrafiltration process, the blood oxygen saturation is improved, microthrombus is filtered, electrolyte is adjusted and blood temperature is maintained, thereby reducing the burden on the patient's lungs. Compared with the existing extracorporeal membrane oxygenation device, the system is more compact in structure, has less trauma and fills the treatment gap between traditional oxygen inhalation, respirator and full-function extracorporeal membrane oxygenation.

[0022] The advantages of the additional aspects of the present application will be given in the following description, some of which will become apparent from the following description, or will be understood through practice of the present application. BRIEF DESCRIPTION OF DRAWINGS

[0023] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the following will briefly introduce the drawings needed to be used in the embodiments or the prior art description. Obviously, the drawings in the following description only show some embodiments of the present application, and for those skilled in the art, other drawings can also be obtained from these drawings without creative labor. In addition, the sizes or distances between each other are exaggerated for showing the positions of the components, and the schematic diagram is only used for illustration.

[0024] Figure 1 is the overall schematic diagram of the system provided by the embodiments of the present application;

[0025] Figure 2is a cross-sectional view of an oxygenation device provided by an embodiment of the present application;

[0026] Figure 3 is a motion line diagram of an oxygenation device provided by an embodiment of the present application;

[0027] Figure 4 is a running structure diagram of a breathing assistance system provided by an embodiment of the present application;

[0028] In the figure: 1, venous bleeding catheter; 2, power blood pump; 3, control system; 4, oxygenation device; 41, central tube; 411, blood inlet; 412, blood slot; 413, central cavity; 42, front cover; 421, oxygen outlet; 422, blood outlet; 43, oxygenation membrane wire layer; 44, inner sleeve; 441, oxygenation cavity; 45, blood ultrafiltration membrane; 46, outer sleeve; 461, constant-temperature ultrafiltration liquid inlet; 462, constant-temperature ultrafiltration cavity; 463, constant-temperature ultrafiltration liquid outlet; 47, outer clasp; 48, inner clasp; 49, rear cover; 491, oxygen inlet; 5, oxygen supply device; 6, ultrafiltration device; 7, constant-temperature ultrafiltration device; 8, venous blood return catheter; 9, monitoring device; DETAILED DESCRIPTION

[0029] It should be noted that the following detailed description is exemplary and is intended to provide further explanation of the present application. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. Furthermore, it should be understood that the terms "comprise" and / or "comprising", when used in this specification, indicate the presence of stated features, steps, operations, devices, components and / or combinations thereof.

[0030] Term explanation:

[0031] Ultrafiltration device: refers to a device for generating, storing or circulating ultrafiltration liquid, which can pass through the blood ultrafiltration membrane through the transmembrane pressure difference, taking away small molecular waste, excess water and adjusting electrolyte concentration in the blood.

[0032] Constant-temperature ultrafiltration device: refers to a device capable of controlling the temperature of ultrafiltration liquid to maintain it within a certain temperature range, which not only assumes the function of ultrafiltration but also is responsible for maintaining the temperature of blood.

[0033] Example 1

[0034] As shown in Figure 1 The present embodiment proposes a percutaneous intervention breathing assistance system, which includes an oxygenation ultrafiltration system, a catheter system and a power system; the oxygenation ultrafiltration system includes an oxygenation device 4, an ultrafiltration device 6 and an oxygen supply device 5, as shown in Figure 2As shown, the oxygenation device 4 has a center cavity 413, an oxygenation cavity 441 and a constant temperature ultrafiltration cavity 462 distributed in turn along the radial direction, the oxygenation cavity 441 and the constant temperature ultrafiltration cavity 462 are provided with an oxygenation membrane filament layer 43 and a blood ultrafiltration membrane 45 respectively, the oxygen supply device 5 is connected to both ends of the oxygenation membrane filament layer 43, and the ultrafiltration device 6 is connected to the constant temperature ultrafiltration cavity 462; the catheter system connects the patient's venous blood with the center cavity 413 and the constant temperature ultrafiltration cavity 462, and the power system is installed in the catheter system to provide power for blood flow.

[0035] By arranging the center cavity 413, the oxygenation cavity 441 and the constant temperature ultrafiltration cavity 462 of the oxygenation device 4 in layers along the radial direction, and by arranging the oxygenation membrane filament layer 43 and the blood ultrafiltration membrane 45, the blood can complete oxygen exchange and ultrafiltration in the oxygenation device 4 in turn, without the need for additional independent oxygenation module and ultrafiltration module, which simplifies the system structure, shortens the blood flow path, reduces the blood extracorporeal time, and reduces the risk of blood injury.

[0036] As shown in Figure 1 , Figure 3 , the catheter introduces the venous blood with low oxygen concentration into the power blood pump 2, and then transports it to the oxygenation device 4, penetrates the oxygenation membrane filament to exchange blood oxygen, and performs ultrafiltration through the constant temperature ultrafiltration module and maintains the output blood temperature at the normal core body temperature, and then transports the constant temperature oxygenation blood back to the vein to improve the patient's oxygen saturation. The application object of the system is patients with impaired respiratory function who do not need extracorporeal membrane oxygenation. By adding the ultrafiltration device 6 on the basis of oxygenation, blood filtration can be realized, and by the layered chamber design, oxygenation and ultrafiltration are completed in the same device, which is more suitable for the dual needs of blood purification and oxygenation of patients with moderate respiratory dysfunction, and fills the treatment gap of the prior art.

[0037] As shown in Figure 2 , the oxygenation device 4 has a center tube 41, one end of the center tube 41 is a blood inlet 411, the other end is sealed, the center tube 41 is the center cavity 413, and a plurality of blood through slots 412 are arranged in an array on the wall of the center tube 41, the blood through slots 412 penetrate the wall of the center tube 41 along the radial direction.

[0038] The center tube 41 is sealed at one end, which can avoid blood leakage from the end of the center tube 41 not connected to the power system, and ensure that the blood can pass through the blood passing slot 412 on the tube wall into the oxygenation cavity 441, and guarantee the sealing and integrity of the blood flow. The arrayed blood passing slots 412 can make the blood in the center cavity 413 uniformly dispersed and flow out, avoid blood accumulation in a local area leading to uneven oxygenation, increase the contact area between the blood and the oxygenation membrane filament layer 43, and thus improve the blood oxygen exchange efficiency; the passing slots penetrate the tube wall along the radial direction, which conforms to the direction of blood flow from the center cavity 413 to the oxygenation cavity 441, reduces the blood flow resistance, and reduces the load of the power system.

[0039] The oxygenation device 4 further comprises an inner clamping ring 48, which is sleeved on both ends of the oxygenation membrane filament layer 43 and fixes the oxygenation membrane filament layer 43 on the center tube 41.

[0040] The inner clamping ring 48 plays a fixing role on both ends of the oxygenation membrane filament layer 43, which can avoid the displacement or shedding of the membrane filaments due to blood flow impact when the blood passes through the oxygenation membrane filament layer 43, guarantee the stability of the structure of the oxygenation membrane filament layer 43, and thus ensure the continuous and stable progress of the blood oxygen exchange process. The oxygenation membrane filament layer 43 fixed by the inner clamping ring 48 is wrapped outside the center tube 41, and after the blood flows out from the blood passing slot 412 of the center tube 41, it can directly enter the oxygenation membrane filament layer 43, which shortens the distance of the blood from the center cavity 413 to the membrane filament layer and reduces the flow resistance.

[0041] Further, the oxygenation device 4 further comprises an inner sleeve 44, an outer clamping ring 47, an outer sleeve 46, and a rear cover 49. One end of the inner sleeve 44 is installed on the inner clamping ring 48, and the other end is suspended. The outer clamping ring 47 is sleeved on both ends of the blood ultrafiltration membrane 45 and fixes the blood ultrafiltration membrane 45 on the inner sleeve 44. The outer sleeve 46 is installed on the outer clamping ring 47. The rear cover 49 is located at the suspended end of the inner sleeve 44 and is installed on the inner clamping ring 48 and the outer clamping ring 47. The outer side of the oxygenation membrane filament layer 43, the inner side of the inner sleeve 44, and the rear cover 49 form the oxygenation cavity 441. The oxygenation cavity 441 is located at one end of the blood ultrafiltration membrane 45. The outer side of the blood ultrafiltration membrane 45 and the inner side of the outer sleeve 46 form the constant-temperature ultrafiltration cavity 462.

[0042] The oxygenation cavity 441 formed by the inner sleeve 44, the rear cover 49 and the oxygenation membrane filament layer 43 can prevent blood from leaking during the oxygenation process. The oxygenation cavity 441 is located at one end of the blood ultrafiltration membrane 45, so that the blood after oxygenation can directly flow into the blood ultrafiltration membrane 45, shortening the blood flow path and reducing the blood off-body time. The outer clasp 47 fixes the blood ultrafiltration membrane 45 on the inner sleeve 44, ensuring the stability of the position of the blood ultrafiltration membrane 45 and avoiding the displacement of the membrane body when the blood flows through, which affects the filtration effect. The outer sleeve 46 cooperates with the blood ultrafiltration membrane 45 to form a constant-temperature ultrafiltration cavity 462, which provides a space for the ultrafiltrate and ensures that the ultrafiltrate can fully exchange heat and substances with the blood.

[0043] The blood ultrafiltration membrane 45 is a hollow fiber ultrafiltration membrane material, preferably a medical polyether sulfone with good biocompatibility. When the oxygenated blood flows through the blood ultrafiltration membrane 45, under the action of the pressure difference, the water, electrolytes and small molecular metabolic waste in the blood can pass through the micropores on the membrane and enter the constant-temperature ultrafiltration cavity 462, and exchange with the constant-temperature ultrafiltrate in the cavity. The cell components and proteins in the blood are retained, thereby realizing the purification of the blood, the balance adjustment of the electrolytes and the control of the liquid volume. At the same time, the constant-temperature ultrafiltrate in the constant-temperature ultrafiltration cavity 462 exchanges heat with the blood through the membrane wall, so that the temperature of the blood is stabilized within a set range.

[0044] The oxygenation device 4 further comprises a front cover 42 located at the non-hanging end of the inner sleeve 44 and installed on the inner clasp 48 and the outer clasp 47. The front cover 42 is provided with a blood outlet 422 located at the other end of the blood ultrafiltration membrane 45.

[0045] The front cover 42 is installed on the inner clasp 48 and the outer clasp 47, and cooperates with the rear cover 49 to realize the sealing of both ends of the oxygenation device 4, so as to avoid the leakage of blood or oxygen from both ends of the device and ensure the sealing of the internal chamber of the device. The blood outlet 422 is arranged at the other end of the blood ultrafiltration membrane 45, so that the blood filtered and adjusted by the blood ultrafiltration membrane 45 can directly flow out from the blood outlet 422, reducing the blood flow resistance and ensuring that each part of the blood is filtered and then flows out, thereby ensuring the blood purification effect.

[0046] The rear cover 49 is provided with an oxygen inlet 491, and the front cover 42 is provided with an oxygen outlet 421. The oxygen inlet 491 and the oxygen outlet 421 are located at both ends of the oxygenation membrane filament layer 43.

[0047] The oxygen inlet 491 and the oxygen outlet 421 are connected to two ends of the oxygenation membrane filament layer 43 respectively, so that oxygen can enter the oxygenation membrane filament layer 43 from the oxygen inlet 491, flow along the axial direction of the membrane filament, and finally be discharged from the oxygen outlet 421, ensuring that oxygen is uniformly distributed and smoothly flows in the membrane filament, avoiding the situation that the oxygen supply is insufficient in the local membrane filament, improving the contact efficiency of blood and oxygen, and guaranteeing the blood oxygen exchange effect.

[0048] As shown in Figure 1 , the catheter system includes a venous blood outlet catheter 1 and a venous blood return catheter 8, the power system includes a power blood pump 2, one end of the venous blood outlet catheter 1 is connected to the venous blood of the patient, and the other end is connected to the blood inlet 411 of the central tube 41 through the power blood pump 2, one end of the venous blood return catheter 8 is connected to the blood outlet 422 of the front cover 42, and the other end is connected to the venous blood of the patient.

[0049] The venous blood outlet catheter 1 and the venous blood return catheter 8 preferably adopt double-lumen jugular vein catheters. The power blood pump 2 adopts a high-hemocompatible axial flow pump, centrifugal pump or mixed flow pump to provide blood flow power for the whole system.

[0050] The venous blood outlet catheter 1 is used to introduce the venous blood with a lower blood oxygen concentration in the patient into the system, and the venous blood return catheter 8 is used to send the treated blood back to the patient. The power blood pump 2 is connected between the venous blood outlet catheter 1 and the blood inlet 411 of the central tube 41, and can pressurize the introduced venous blood to provide power for the blood flow in the system, solve the problem that the venous blood pressure of the patient is insufficient to drive the blood to complete the whole flow process, and ensure that the blood can smoothly complete the oxygenation, ultrafiltration and other treatment processes.

[0051] As shown in Figure 1 , Figure 4 , the auxiliary system further includes a monitoring device 9, which mainly monitors the physiological parameters related to blood at the inlet and outlet sides of the oxygenation device 4, monitors the blood oxygen level of the patient, and evaluates the oxygenation efficiency. The monitoring device 9 includes a blood oxygen monitoring module installed on the venous blood outlet catheter 1 and a blood oxygen monitoring module and a temperature monitoring module installed on the venous blood return catheter 8.

[0052] The blood oxygen monitoring module on the venous bleeding catheter 1 can monitor the blood oxygen parameters of the patient's venous blood entering the system in real time, and the blood oxygen monitoring module on the venous blood return catheter 8 can monitor the blood oxygen parameters of the blood flowing out of the system. By comparing the blood oxygen parameters of the two, the blood oxygen exchange efficiency of the system can be directly judged, and medical staff can adjust system parameters such as oxygen supply amount and power blood pump 2 speed according to efficiency changes to ensure treatment effect. The temperature monitoring module on the venous blood return catheter 8 can monitor the blood temperature flowing back to the patient's body in real time. When the temperature monitoring module detects that the blood temperature deviates from the normal range, it can feed back a signal to the constant-temperature ultrafiltration device 7 to adjust the ultrafiltration liquid temperature, so that the blood temperature is maintained at the target temperature, reducing blood ex vivo injury and ensuring treatment safety.

[0053] The oxygenation ultrafiltration system further comprises a constant-temperature ultrafiltration device 7, which is in communication with the constant-temperature ultrafiltration liquid inlet 461 and the constant-temperature ultrafiltration liquid outlet 463 on the outer sleeve 46. The ultrafiltration device 6 is in communication with the constant-temperature ultrafiltration device 7.

[0054] The constant-temperature ultrafiltration device 7 delivers constant-temperature ultrafiltration liquid to the constant-temperature ultrafiltration cavity 462. The ultrafiltration liquid adjusts the blood temperature to the normal range through heat exchange with the blood, avoiding injury to the patient caused by temperature changes after the blood is taken out of the body. At the same time, material exchange can be carried out between the ultrafiltration liquid and the blood, cooperating with the filtration effect of the blood ultrafiltration membrane 45 to realize the adjustment of electrolytes and the filtration of waste in the blood; the ultrafiltration device 6 is in communication with the constant-temperature ultrafiltration device 7, which can process the used ultrafiltration liquid, so that the ultrafiltration liquid can be recycled, reducing the consumption of ultrafiltration liquid.

[0055] The control system 3 is connected with the power blood pump 2 for real-time regulation and control of the speed of the power blood pump 2 to control the overall blood flow and system pressure in the auxiliary system.

[0056] When installing:

[0057] The oxygenation membrane wire layer 43 in the oxygenation device 4 is wound on the surface of the center tube 41. After the oxygenation membrane wire layer 43 reaches a certain thickness, the two end inner clamps 48 are sleeved into the two ends of the oxygenation membrane wire layer 43 for fastening and assembly. Then the inner sleeve 44 is sleeved on the assembled oxygenation membrane wire layer 43, and then the blood ultrafiltration membrane 45 is sleeved outside the inner sleeve 44 and fixed by the outer clamp 47. Then the outer sleeve 46 is installed, and finally the front cover 42 and the rear cover 49 at both ends are installed.

[0058] A jugular vein catheter is inserted to introduce venous blood with low oxygen concentration into a powered blood pump 2. The control system 3 regulates the pump's operation in real time, delivering the blood to the oxygenation device 4. The blood penetrates the oxygenation membrane fiber layer 43 for oxygenation, then collects and flows through an ultrafiltration membrane to filter potential microthrombi, regulate electrolytes, and filter blood waste. Finally, the blood is returned to the vein, thereby improving the patient's blood oxygen saturation. During operation, a temperature-controlled ultrafiltration device 7, while regulating blood electrolytes and filtering blood waste, provides a constant temperature to the system, preventing damage from hypothermia.

[0059] Example 2

[0060] This embodiment provides a method for operating a percutaneous interventional respiratory support system as described in Embodiment 1, comprising: introducing the patient's venous blood into the power system via a catheter, and delivering the blood to the oxygenation device 4 under the pressure of the power system; the blood passing through the oxygenation membrane fiber layer 43 in the oxygenation device 4, exchanging blood oxygen with the oxygen inside the membrane fiber, thereby increasing the blood oxygen level; injecting constant temperature ultrafiltration solution into the constant temperature ultrafiltration chamber 462 of the constant temperature ultrafiltration system, and the oxygenated blood flowing through the blood ultrafiltration membrane 45 to filter microthrombi and blood waste, while simultaneously regulating electrolytes and adjusting the blood temperature to the normal temperature range; and returning the processed blood to the patient's vein via a catheter.

[0061] like Figure 1 As shown, the overall workflow of this respiratory support system is as follows: Patient blood is introduced into the power pump 2 via the venous bleeding catheter 1. Under the pressure of the power pump 2, the blood is delivered to the oxygenation device 4. The blood passes through the oxygenation membrane fiber layer 43 from the central cavity 413 of the oxygenation device 4 and enters the oxygenation chamber 441. During the passage through the oxygenation membrane fiber layer 43, the blood exchanges oxygen with the oxygen inside the hollow membrane fiber, thereby increasing the blood oxygen level. Subsequently, the blood is collected and flows through a constant-temperature ultrafiltration membrane to filter potential microthrombi and to regulate electrolytes and filter blood waste. Finally, it flows out through the blood outlet 422 and is returned to the patient's vein via the venous return catheter 8, restoring the patient's blood oxygen saturation level to within the normal range, regulating electrolytes, and filtering harmful substances, thus ensuring the patient's vital functions.

[0062] While the specific embodiments of the present invention have been described above in conjunction with the accompanying drawings, this is not intended to limit the scope of protection of the present invention. Those skilled in the art should understand that various modifications or variations that can be made by those skilled in the art without creative effort based on the technical solutions of the present invention are still within the scope of protection of the present invention.

Claims

1. A percutaneous interventional breathing assist system, characterized by, The oxygenation ultrafiltration system, the catheter system and the power system are included. The oxygenation ultrafiltration system includes an oxygenation device, an ultrafiltration device and an oxygen supply device, the oxygenation device has a central cavity, an oxygenation cavity and a constant temperature ultrafiltration cavity distributed in turn along the radial direction outward, the oxygenation cavity and the constant temperature ultrafiltration cavity are provided with an oxygenation membrane filament layer and a blood ultrafiltration membrane respectively, the oxygen supply device is connected to both ends of the oxygenation membrane filament layer, and the ultrafiltration device is connected to the constant temperature ultrafiltration cavity. The catheter system is connected to the central cavity and the constant temperature ultrafiltration cavity for patient venous blood, and the power system is installed in the catheter system to provide blood flow power. The oxygenation device has a central tube, one end of the central tube is a blood inlet, and the other end is sealed, and the central tube is the central cavity. The oxygenation device further includes an inner clamping ring, the inner clamping ring is sleeved on both ends of the oxygenation membrane filament layer and fixes the oxygenation membrane filament layer on the central tube. The oxygenation device further includes an inner sleeve, an outer clamping ring, an outer sleeve and a rear cover, one end of the inner sleeve is installed on the inner clamping ring, the outer clamping ring is sleeved on both ends of the blood ultrafiltration membrane, the outer sleeve is installed on the outer clamping ring, the rear cover is located at one end of the inner sleeve and is installed on the inner clamping ring and the outer clamping ring, and the oxygenation membrane filament layer, the inner side of the inner sleeve and the rear cover form the oxygenation cavity. The oxygenation ultrafiltration system further includes a constant temperature ultrafiltration device, which is connected to the constant temperature ultrafiltration liquid inlet and outlet on the outer sleeve.

2. The percutaneous interventional breathing assistance system of claim 1, wherein, The oxygenation device further includes a front cover, which is located at the non-hanging end of the inner sleeve and is installed on the inner clamping ring and the outer clamping ring, and the front cover is provided with a blood outlet, which is located at the other end of the blood ultrafiltration membrane.

3. The percutaneous interventional breathing assistance system of claim 2, wherein, The rear cover is provided with an oxygen inlet, and the front cover is provided with an oxygen outlet, and the oxygen inlet and the oxygen outlet are located at both ends of the oxygenation membrane filament layer.

4. The percutaneous interventional breathing assistance system of claim 2, wherein, The catheter system includes a venous blood outlet catheter and a venous blood return catheter, the power system includes a power blood pump, one end of the venous blood outlet catheter is connected to patient venous blood, and the other end is connected to the blood inlet of the central tube through the power blood pump, one end of the venous blood return catheter is connected to the blood outlet of the front cover, and the other end is connected to patient venous blood.

5. Percutaneous interventional breathing assistance system according to claim 4, characterized in that The monitoring device includes a blood oxygen monitoring module installed on the venous blood outlet catheter and a blood oxygen monitoring module and a temperature monitoring module installed on the venous blood return catheter.

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