A mixing device for the production of cefuroxime axetil

Abstract

This invention relates to the field of cefuroxime axetil production technology, and provides a mixing device for cefuroxime axetil production, including a first mixing cylinder assembly, a second mixing cylinder assembly, and a cefuroxime axetil pretreatment mechanism. The first mixing cylinder assembly is used to prepare qualified cefuroxime axetil coated microparticles as a primary product. The second mixing cylinder assembly is used to mix and flavor the qualified cefuroxime axetil coated microparticles to form the final cefuroxime axetil dry suspension product. The cefuroxime axetil pretreatment mechanism is used to hammer, grind, and screen the cefuroxime axetil powder. The cefuroxime axetil pretreatment mechanism includes a pretreatment cylinder, which is equipped with a hammering component, a grinding component, and a screening component. By setting up a cefuroxime axetil pretreatment mechanism, this invention integrates the three functions of hammering, grinding, and screening into one unit, effectively solving the problems of cefuroxime axetil raw material agglomeration and uneven particle size, providing a raw material foundation with uniform particle size for subsequent coating processes.

Description

Technical Field

[0001] This invention belongs to the field of cefuroxime axetil production technology, specifically relating to a mixing device for the production of cefuroxime axetil. Background Technology

[0002] Cefuroxime axetil raw material has a strong bitter taste. To improve palatability, it is usually coated and formulated into a dry suspension in clinical practice. However, existing production equipment has significant deficiencies in the coating pretreatment stage:

[0003] First, traditional equipment lacks a dedicated raw material pretreatment mechanism, which fails to effectively address the clumping and uneven particle size issues in cefuroxime axetil raw materials, directly affecting the uniformity and integrity of the coating. Second, due to insufficient pretreatment, coated microparticles often exhibit uneven coating thickness and incomplete coating, resulting in incomplete masking of bitterness and severely impacting the patient's medication experience. Third, existing technologies lack sufficient control over raw material particle size, which not only increases the amount of coating material used and production costs but also easily leads to uneven mixing of the drug and excipients, ultimately affecting the consistency and stability of the product's dissolution.

[0004] Therefore, there is an urgent need to develop a mixing device that can effectively pretreat cefuroxime axetil raw materials to ensure coating quality from the source and improve bitterness masking effect. Summary of the Invention

[0005] This invention provides a mixing apparatus for the production of cefuroxime axetil, thereby solving at least one of the aforementioned technical problems. This invention is achieved through the following technical solution:

[0006] A mixing device for the production of cefuroxime axetil includes a first mixing cylinder assembly, a second mixing cylinder assembly, and a cefuroxime axetil pretreatment mechanism. The output end of the first mixing cylinder assembly is connected to the input end of the second mixing cylinder assembly. The first mixing cylinder assembly is used to prepare qualified cefuroxime axetil coated microparticles. The second mixing cylinder assembly is used to mix and flavor the qualified cefuroxime axetil coated microparticles to form the final cefuroxime axetil dry suspension product. The output end of the cefuroxime axetil pretreatment mechanism is connected to the input end of the first mixing cylinder assembly and is used to hammer, crush, grind, and screen the cefuroxime axetil powder to ensure that the particle size of the cefuroxime axetil powder input to the first mixing cylinder assembly is within a preset range.

[0007] The cefuroxime axetil pretreatment mechanism includes a pretreatment cylinder, which contains a hammering assembly, a grinding assembly, and a screening assembly. The grinding assembly includes a grinding disc rotatably connected within the grinding chamber. The grinding disc engages with the inner wall of the grinding chamber to grind the cefuroxime axetil powder. The hammering assembly includes a hammering cylinder slidably connected within the pretreatment cylinder via a reciprocating drive assembly. The hammering cylinder engages with the top surface of the grinding disc to hammer the cefuroxime axetil powder. The screening assembly includes a screening agitator and a centrifugal air compressor. The screening agitator is rotatably connected within the screening chamber of the pretreatment cylinder. The inlet of the centrifugal air compressor is connected to the output end of the screening chamber, and the outlet of the centrifugal air compressor is connected to the input end of the mixing cylinder assembly.

[0008] Preferably, the reciprocating drive assembly includes a driven shaft rotatably connected inside the pretreatment cylinder, the driven shaft passing through the hammer cylinder, a grinding disc fixedly connected to the driven shaft, a guide cap fixedly connected to the driven shaft, a feed funnel fixedly connected to the top of the pretreatment cylinder, and the guide cap located directly below the feed funnel.

[0009] The guide cap has several initial material inlets circumferentially, and an annular groove is formed on the inner wall of the guide cap. An annular slider is fixedly connected to the hammer cylinder. The annular slider slides up and down in the annular groove. A reset elastic element is fixedly connected to the bottom inner wall of the annular groove. A mating block is fixedly connected to the driven rotating shaft. An inclined mating ring is fixedly connected to the inner wall of the hammer cylinder. The mating block slides on the inclined mating ring.

[0010] Preferably, the reciprocating drive assembly further includes a pretreatment drive assembly, which includes a pretreatment drive motor. The pretreatment drive motor is fixedly connected to the side wall of the pretreatment cylinder. The output end of the pretreatment drive motor is connected to a drive spindle via a coupling. A bevel gear one is fixedly connected to the drive spindle, and a bevel gear two is fixedly connected to the driven shaft. The bevel gear one and the bevel gear two mesh with each other.

[0011] A recycling channel is provided at the bottom of the screening chamber. An electric gate is rotatably connected inside the recycling channel. The end of the recycling channel away from the screening chamber is connected to a recycling auger.

[0012] Preferably, a sweeping brush is fixedly connected to the bottom of the grinding disc, and a plurality of grinding ball mounting grooves are opened in the radial direction of the grinding disc. Grinding balls are slidably connected in the grinding ball mounting grooves, and the grinding balls are connected to the inner wall of the grinding ball mounting grooves through a reset elastic element.

[0013] Preferably, the mixing cylinder assembly one includes, from top to bottom, a hot melt mixing cylinder, a cooling granulation cylinder, and a cyclone screening cylinder. The hot melt mixing cylinder is used to prepare cefuroxime axetil suspension, the cooling granulation cylinder is used to prepare cefuroxime axetil coated microparticles, and the cyclone screening cylinder is used to screen the cefuroxime axetil coated microparticles and input the qualified cefuroxime axetil coated microparticles into the mixing cylinder assembly two.

[0014] Preferably, the hot melt mixing cylinder is provided with a hot melt component and a mixing component. The hot melt component is used to melt the material input into the hot melt mixing cylinder, and the mixing component is used to stir the material input into the hot melt mixing cylinder.

[0015] The hot melt assembly includes a heating rod, which is installed in a medium heating chamber inside the hot melt mixing cylinder. The medium heating chamber is connected to a medium input pipe and a medium output pipe on the hot melt mixing cylinder.

[0016] The mixing assembly includes a mixing drive motor mounted on a hot melt mixing cylinder. The output end of the mixing drive motor is connected to a mixing shaft via a coupling. The mixing shaft is rotatably connected inside the mixing chamber. Several mixing agitators are fixedly connected to the mixing shaft. Several anti-sticking scrapers are fixedly connected to the bottom of the mixing shaft. The output end of the mixing chamber is connected to a cooling granulation cylinder via a suspension output pipe.

[0017] Preferably, the cooling granulation cylinder includes a cooling chamber and a two-fluid airflow atomizer. The two-fluid airflow atomizer is fixedly connected to the output end of the hot melt mixing cylinder. The two-fluid airflow atomizer is used to atomize the cefuroxime axetil suspension into tiny droplets. After the droplets come into contact with the cooling medium in the cooling chamber, they are rapidly cooled and solidified to form the initial product of cefuroxime axetil coated microparticles.

[0018] The cooling chamber is equipped with a cooling medium inlet pipe, a cooling medium outlet pipe, a gas distribution plate, and a cooling temperature sensor. The cooling medium inlet pipe is used to introduce cooling medium into the cooling chamber, and the cooling medium outlet pipe is used to export the cooling medium after heat exchange. The gas distribution plate is located at the output end of the cooling medium inlet pipe and is used to evenly distribute the cooling airflow to ensure that the atomized cefuroxime axetil suspension droplets are uniformly cooled and solidified during the cooling process. The cooling temperature sensor is used to monitor the temperature inside the cooling chamber in real time to ensure that the cooling process is carried out within the preset temperature range.

[0019] Preferably, the cyclone screening cylinder includes a discharge pipe, which is rotatably connected to the output end of the cooling granulation cylinder. A centrifugal screen is fixedly connected to the end of the discharge pipe away from the output end of the cooling granulation cylinder. The centrifugal screen is sealed at the bottom by an arc-shaped cylinder body, which is rotatably connected to an mounting partition. A recovery auger is connected to the output end of the arc-shaped cylinder body. A screening drive motor is fixedly connected to the mounting partition. A screening drive gear is fixedly connected to the output end of the screening drive motor. A screening driven gear is fixedly connected to the arc-shaped cylinder body. The screening driven gear meshes with the screening drive gear. An annular spray plate is fixedly connected to the cyclone screening cylinder. The annular spray plate is provided with several oblique spray holes. The end of the oblique spray hole located outside the cyclone screening cylinder is connected to a compressed air annular air supply pipe, which is connected to the output end of an external air compressor.

[0020] A conical cylinder 1 is fixedly connected inside the cyclone screening cylinder by several support rods. A conical cylinder 2 is fixedly connected to the inner wall of the top of the cyclone screening cylinder. A negative pressure communication hole is opened at the rear of the conical cylinder 2. The negative pressure communication hole is used to connect with an external negative pressure generator. The conical cylinder 1 and the conical cylinder 2 are coaxial, and the conical cylinder 2 is located inside the conical cylinder 1. The discharge pipe passes through the conical cylinder 1 and the conical cylinder 2. A deflector plate mounting ring is fixedly connected inside the conical cylinder 1. Several electric cyclone deflector plates are rotatably connected to the deflector plate mounting ring.

[0021] An arc-shaped sweeping brush is fixedly connected to the material drop pipe inside the conical cylinder. The arc-shaped sweeping brush fits into the inside of the annular bottom of the conical cylinder. The annular bottom of the conical cylinder is connected to a discharge pipe, which is connected to the collection bin below the mounting partition.

[0022] Preferably, the mixing cylinder assembly two includes a mixing cylinder mounting frame, on which a mixing and seasoning cylinder body and a mixing and seasoning drive motor are mounted. The output end of the mixing and seasoning drive motor is fixedly connected to a mixing and seasoning stirring paddle. The top of the mixing and seasoning cylinder body is provided with a qualified cefuroxime axetil coated microparticle inlet and a seasoning inlet. The qualified cefuroxime axetil coated microparticle inlet is connected to the output end of the mixing cylinder assembly one. The bottom of the mixing and seasoning cylinder body is provided with a dry suspension outlet.

[0023] Preferably, a mixing apparatus for the production of cefuroxime axetil further includes an online quality monitoring and feedback control system, which includes:

[0024] The particle size monitoring module is located at the output end of the screening chamber and is used to monitor and output the particle size distribution signal of the pretreated cefuroxime axetil powder in real time.

[0025] The central processing unit is used to receive particle size distribution signals and compare the received signal values ​​with the internally preset standard value range;

[0026] The feedback actuator has its control input connected to the control signal output of the central processing unit. The feedback actuator includes a speed regulator for adjusting the speed of the pre-processing drive motor. When the received particle size distribution signal deviates from the preset standard value, the central processing unit outputs a control signal to the speed regulator to adjust the speed of the pre-processing drive motor, thereby changing the hammering and grinding intensity.

[0027] Compared with the prior art, the present invention has the following beneficial effects:

[0028] (1) By setting up a pretreatment mechanism for cefuroxime axetil, the present invention integrates the functions of hammering, grinding and screening, effectively solving the problems of cefuroxime axetil raw material agglomeration and uneven particle size, providing a raw material base with uniform particle size for subsequent coating process, ensuring the integrity and uniformity of coating from the source, and significantly improving the bitterness masking effect.

[0029] (2) The present invention converts rotational motion into precise linear reciprocating motion through a reciprocating drive assembly consisting of a driven rotating shaft, a guide cap, an annular chute, an annular slider, a reset elastic element, a mating block, and an inclined mating ring. This enables the hammering cylinder to periodically and efficiently hammer the material. Furthermore, by setting up a recycling channel, an electric gate, and a recycling auger, the invention enables the automatic collection and recycling of substandard coarse powder, forming a closed-loop production system and improving the utilization rate of raw materials.

[0030] (3) The cyclone screening cylinder of the present invention realizes efficient and precise three-stage sorting of coated microparticles (unqualified heavy products, qualified products, and unqualified light products). It has high sorting efficiency and good precision. Through the ingenious combination of negative pressure and centrifugal force, it accurately separates microparticles of different weights. The qualified product collection rate is high. Furthermore, the automatic recycling and processing of unqualified products is realized through the recovery auger and negative pressure outlet. The arc-shaped sweeping brush design ensures that all qualified products can be successfully collected into the collection bin, avoiding residue.

[0031] (4) By monitoring the output in real time and adjusting the input, the present invention achieves active and precise control of the particle size of the pre-treated powder, ensuring the uniformity and stability of the material quality input to the subsequent mixing and coating process from the source, effectively avoiding the final product quality problems caused by the fluctuation of the pre-treatment process, and significantly improving the reliability of the entire production system and the consistency of product quality. Attached Figure Description

[0032] The accompanying drawings are provided to further illustrate the invention and form part of the specification. They are used in conjunction with embodiments of the invention to explain the invention and do not constitute a limitation thereof. In the drawings:

[0033] Figure 1 This is a three-dimensional schematic diagram of a mixing device for the production of cefuroxime axetil provided by the present invention;

[0034] Figure 2 This is a three-dimensional schematic diagram of the cefuroxime axetil pretreatment mechanism in this invention;

[0035] Figure 3 This is a cross-sectional view of the cefuroxime axetil pretreatment mechanism in this invention;

[0036] Figure 4 This is a schematic diagram of the internal structure of the guide cap in this invention;

[0037] Figure 5 This is a cross-sectional view of the grinding disc in this invention;

[0038] Figure 6 This is a three-dimensional schematic diagram of the mixing cylinder assembly one in this invention;

[0039] Figure 7 This is a cross-sectional view of the mixing cylinder assembly one in this invention;

[0040] Figure 8 This is a cross-sectional view of the hot melt mixing cylinder in this invention;

[0041] Figure 9 This is a cross-sectional view of the cyclone screening cylinder in this invention;

[0042] Figure 10 This is a cross-sectional view of the mixing cylinder assembly two in this invention.

[0043] In the diagram: 1. Mixing cylinder assembly one; 10. Hot melt mixing cylinder; 100. Heating rod; 101. Medium heating chamber; 102. Medium input pipe; 103. Medium output pipe; 104. Mixing drive motor; 105. Mixing shaft; 106. Mixing agitator; 107. Anti-sticking scraper; 108. Mixing chamber; 109. Suspension output pipe; 11. Cooling granulation cylinder; 110. Cooling chamber; 111. Two-fluid airflow atomizer; 12. Cyclone screening cylinder; 120. Material discharge pipe; 121. Centrifugal screen; 210. Arc-shaped cylinder; 1211. Recycling auger II; 122. Mounting baffle; 123. Conical cylinder II; 1230. Negative pressure connecting hole; 1231. Support rod; 124. Conical cylinder I; 125. Deflector plate mounting ring; 126. Electric cyclone deflector plate; 127. Arc-shaped sweeping brush; 128. Discharge pipe; 129. Collection bin; 1290. Screening drive motor; 1291. Screening drive gear; 1292. Screening driven gear; 1293. Annular jet plate; 1294. Angled jet hole; 295. Compressed air annular gas delivery pipe; 2. Mixing cylinder assembly two; 20. Mixing cylinder mounting bracket; 21. Mixing seasoning cylinder body; 22. Mixing seasoning drive motor; 23. Mixing seasoning stirring paddle; 24. Qualified cefuroxime axetil coated microparticle inlet; 25. Seasoning feeding port; 26. Dry suspension outlet; 3. Cefuroxime axetil pretreatment mechanism; 30. Pretreatment cylinder; 31. Grinding chamber; 32. Grinding disc; 320. Sweeping brush; 321. Grinding ball mounting groove; 322. Grinding ball; 323. Compound 33. Elastic component 2; 34. Hammering cylinder; 35. Screening agitator; 36. Screening chamber; 37. Driven rotating shaft; 38. Guide cap; 39. Feeding funnel; 30. Initial material feed inlet; 31. Annular chute; 32. Annular slider; 33. Reset elastic component 1; 34. Inclined mating ring; 35. Mating block; 366. Pre-treatment drive motor; 377. Drive spindle; 38. Bevel gear 1; 39. Bevel gear 2; 30. Recycling channel; 31. Electric gate; 32. Recycling auger 1. Detailed Implementation

[0044] The preferred embodiments of the present invention will be described below with reference to the accompanying drawings. It should be understood that the preferred embodiments described herein are for illustration and explanation only and are not intended to limit the present invention.

[0045] Furthermore, in this invention, the use of terms such as "first" and "second" is for descriptive purposes only and does not specifically refer to any order or sequence, nor is it intended to limit the invention. They are merely used to distinguish components or operations described using the same technical terms and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Therefore, a feature defined with "first" or "second" may explicitly or implicitly include at least one of those features. Additionally, the technical solutions and features of the various embodiments can be combined with each other, but this must be based on the ability of those skilled in the art to implement them. If a combination of technical solutions is contradictory or impossible to implement, it should be considered that such a combination of technical solutions does not exist and is not within the scope of protection claimed by this invention.

[0046] Example 1: This embodiment of the invention provides a mixing apparatus for the production of cefuroxime axetil, such as... Figure 1-10 As shown, the system includes a mixing cylinder assembly 1, a mixing cylinder assembly 2, and a cefuroxime axetil pretreatment mechanism 3. The output end of the mixing cylinder assembly 1 is connected to the input end of the mixing cylinder assembly 2. The mixing cylinder assembly 1 is used to prepare qualified cefuroxime axetil coated microparticles. The mixing cylinder assembly 2 is used to mix and flavor the qualified cefuroxime axetil coated microparticles to form the final cefuroxime axetil dry suspension product. The output end of the cefuroxime axetil pretreatment mechanism 3 is connected to the input end of the mixing cylinder assembly 1 and is used to hammer, grind, and screen the cefuroxime axetil powder to ensure that the particle size of the cefuroxime axetil powder input to the mixing cylinder assembly 1 is within a preset range.

[0047] The cefuroxime axetil pretreatment mechanism 3 includes a pretreatment cylinder 30, which contains a hammering assembly, a grinding assembly, and a screening assembly. The grinding assembly includes a grinding disc 32 rotatably connected to a grinding chamber 31. The grinding disc 32 cooperates with the inner wall of the grinding chamber 31 to grind the cefuroxime axetil powder. The hammering assembly includes a hammering cylinder 33 driven by a reciprocating drive assembly and slidably connected to the pretreatment cylinder 30. The hammering cylinder 33 cooperates with the top surface of the grinding disc 32 to hammer the cefuroxime axetil powder. The screening assembly includes a screening agitator 34 and a centrifugal air compressor. The screening agitator 34 is rotatably connected to a screening chamber 35 in the pretreatment cylinder 30. The air inlet of the centrifugal air compressor is connected to the output end of the screening chamber 35, and the air outlet of the centrifugal air compressor is connected to the input end of the mixing cylinder assembly 1.

[0048] The working principle and beneficial effects of the above technical solution are as follows: During operation, cefuroxime axetil powder with different particle sizes is fed into the cefuroxime axetil pretreatment unit 3. The cefuroxime axetil powder is hammered, crushed, ground and screened in sequence by the cefuroxime axetil pretreatment unit 3, thereby ensuring that the particle size of the cefuroxime axetil powder fed into the mixing cylinder assembly 1 is within the preset range. In the pretreatment process of cefuroxime axetil pretreatment unit 3, a preset mass of stearic acid and glyceryl monostearate are added to mixing cylinder assembly 1 for melting. After the stearic acid and glyceryl monostearate have melted, a preset mass of povidone is added to mixing cylinder assembly 1 and mixed evenly with the melted stearic acid and glyceryl monostearate. Then, the cefuroxime axetil powder pretreated by cefuroxime axetil pretreatment unit 3 is fed into mixing cylinder assembly 1 through a centrifugal air compressor and mixed evenly with the remaining substances in mixing cylinder assembly 1 to finally form a cefuroxime axetil suspension. The cefuroxime axetil suspension is then cooled, granulated, and separated by cyclone to form qualified cefuroxime axetil coated microparticles. The cefuroxime axetil coated microparticles are then fed into mixing cylinder assembly 2 and mixed with sweetener, flavoring agent, and suspending agent to form the final product of cefuroxime axetil dry suspension.

[0049] Among them, stearic acid is a white waxy solid flake or granules used to coat cefuroxime axetil powder; povidone is a white powder used to adjust the dissolution rate of cefuroxime axetil powder; and glyceryl monostearate is a white waxy solid used to assist in coating and improve the plasticity of cefuroxime axetil suspension.

[0050] The pretreatment of cefuroxime axetil by the pretreatment mechanism 3 is specifically achieved by driving the hammer cylinder 33 to move up and down repeatedly through the reciprocating drive assembly, thereby hammering the cefuroxime axetil powder falling on the grinding disc 32.

[0051] The pretreatment of cefuroxime axetil by the pretreatment mechanism 3 is specifically achieved by rotating the grinding disc 32, so that the cefuroxime axetil powder falling between the grinding disc 32 and the inner wall of the grinding chamber 31 is ground.

[0052] The screening pretreatment of cefuroxime axetil pretreatment unit 3 specifically involves stirring the hammered and milled cefuroxime axetil powder with a screening stirring paddle 34. During this period, a centrifugal air compressor is started, and cefuroxime axetil powder with a particle size within the preset range is fed into the mixing cylinder assembly 1 under the action of airflow.

[0053] The cefuroxime axetil pretreatment unit 3 hammers, grinds, and screens the cefuroxime axetil powder to ensure the uniformity of the final product specifications of the cefuroxime axetil dry suspension.

[0054] This invention uses a cefuroxime axetil pretreatment unit 3 to hammer, grind, and screen cefuroxime axetil powder, ensuring that the cefuroxime axetil powder entering subsequent processes has a uniform particle size, laying the foundation for high-quality coating. By setting up an independent mixing cylinder assembly 2 to mix and flavor qualified initial products, the dedicated operation avoids interference between upstream and downstream processes, ensuring the uniformity of the final product's taste, flavor, and stability.

[0055] This invention addresses the issues of cefuroxime axetil raw material agglomeration and uneven particle size mentioned in the background art by incorporating a cefuroxime axetil pretreatment mechanism 3. This mechanism integrates hammering, grinding, and screening functions, providing a uniform raw material foundation for subsequent coating processes. The reciprocating motion of the hammering cylinder 33 in the hammering assembly effectively breaks down agglomerated materials, avoiding uneven coating caused by insufficient pretreatment in traditional devices. Furthermore, the grinding process, through the coordinated grinding of the grinding disc 32 and the inner wall of the grinding chamber 31, ensures uniform particle size distribution of the cefuroxime axetil. The cefuroxime axetil powder particle size is within the preset range, ensuring the integrity and uniformity of the coating from the source and significantly improving the bitterness masking effect. Through the cooperation of the screening agitator 34 and the centrifugal air compressor in the screening component, real-time sorting and conveying are achieved, ensuring that only cefuroxime axetil powder with qualified particle size enters the subsequent process, which not only improves the coating quality but also reduces the waste of coating materials and lowers production costs. The continuous and automated pretreatment process not only improves production efficiency but also ensures the consistency and stability of the dissolution of the final product, significantly improving the patient's medication experience.

[0056] Example 2: Based on Example 1, the reciprocating drive assembly includes a driven shaft 36 rotatably connected inside the pretreatment cylinder 30, the driven shaft 36 passing through the hammer cylinder 33, the grinding disc 32 being fixedly connected to the driven shaft 36, a guide cap 360 being fixedly connected to the driven shaft 36, a feed funnel 361 being fixedly connected to the top of the pretreatment cylinder 30, and the guide cap 360 being located directly below the feed funnel 361;

[0057] The guide cap 360 has several initial material inlets 362 circumferentially. The inner wall of the guide cap 360 has an annular groove 363. An annular slider 364 is fixedly connected to the hammer cylinder 33. The annular slider 364 is slidably connected to the annular groove 363. A reset elastic element 365 is fixedly connected to the bottom inner wall of the annular groove 363. A mating block 367 is fixedly connected to the driven rotating shaft 36. An inclined mating ring 366 is fixedly connected to the inner wall of the hammer cylinder 33. The mating block 367 is slidably connected to the inclined mating ring 366.

[0058] The working principle and beneficial effects of the above technical solution are as follows: During operation, cefuroxime axetil powder of varying specifications enters the pretreatment cylinder 30 through the feed funnel 361 and falls to the top of the guide cap 360. Afterward, it continues to slide down through the guide cap 360 and contacts the conical inner wall of the pretreatment cylinder 30. Under gravity, it passes through the initial material feed inlet 362 and falls onto the upper surface of the grinding disc 32. Then, the driven shaft 36 rotates, driving the mating block 367 to rotate. If the mating block 367 and the inclined mating ring 366 are in a certain position... Figure 3 As shown, during the rotation of the driven shaft 36 from 0 to 180 degrees, since the vertical height of the mating block 367 remains constant, the mating block 367 is always slidably connected to the upper surface of the inclined mating ring 366 during rotation. Thus, the inclined mating ring 366 moves downwards under the action of the mating block 367, causing the hammering cylinder 33 to move downwards. When the rotation reaches 180 degrees, the bottom surface of the hammering cylinder 33 is exactly in contact with the grinding disc 32, thereby hammering the cefuroxime axetil powder falling on the grinding disc 32. During the rotation of the driven shaft 36 from 180 to 360 degrees, the hammering cylinder 33 gradually moves upwards under the action of the reset elastic element 365, moving away from the grinding disc 32. As the driven shaft 36 continues to rotate, the hammering cylinder 33 cyclically moves up and down to hammer the cefuroxime axetil powder.

[0059] This invention cleverly transforms the rotational motion of the driven shaft 36 into the precise up-and-down reciprocating motion of the hammer cylinder 33 by setting up a reciprocating drive assembly consisting of a driven shaft 36, a guide cap 360, an annular groove 363, an annular slider 364, a reset elastic element 365, a mating block 367, and an inclined mating ring 366. This achieves periodic and efficient hammering of materials, with a compact structure, reliable transmission, and adjustable hammering force and frequency via rotation speed, making it highly adaptable. The design of the guide cap 360 ensures that the material is evenly dispersed onto the grinding disc 32, avoiding concentrated material drop and improving the pretreatment effect.

[0060] Example 3: Based on Example 2, the reciprocating drive assembly further includes a pre-processing drive assembly. The pre-processing drive assembly includes a pre-processing drive motor 37, which is fixedly connected to the side wall of the pre-processing cylinder 30. The output end of the pre-processing drive motor 37 is connected to a drive spindle 370 via a coupling. A first bevel gear 371 is fixedly connected to the drive spindle 370, and a second bevel gear 372 is fixedly connected to the driven shaft 36. The first bevel gear 371 and the second bevel gear 372 mesh with each other.

[0061] A recycling channel 38 is provided at the bottom of the screening chamber 35. An electric gate 380 is rotatably connected inside the recycling channel 38. The end of the recycling channel 38 away from the screening chamber 35 is connected to a recycling auger 39.

[0062] The working principle and beneficial effects of the above technical solution are as follows: When the pretreatment drive component is working, the pretreatment drive motor 37 drives the drive spindle 370 to rotate, the drive spindle 370 drives the first bevel gear 371 to rotate, the first bevel gear 371 drives the second bevel gear 372 to rotate, the second bevel gear 372 drives the driven shaft 36 to rotate, and the continuous rotation of the driven shaft 36 drives the hammering cylinder 33 to move up and down in a cyclical manner to hammer the cefuroxime axetil powder.

[0063] After being hammered, crushed, and ground, cefuroxime axetil powder falls into the screening chamber 35. Cefuroxime axetil powder with a particle size within the preset range is fed into the mixing cylinder assembly 1 under the action of a centrifugal air compressor. After screening, cefuroxime axetil powder with a particle size still larger than the preset particle size is opened by the rotation of the electric gate 380. After falling into the recycling channel 38, the cefuroxime axetil powder is then output through the recycling auger 39 and re-input to the input end of the cefuroxime axetil pretreatment mechanism 3 for further pretreatment.

[0064] This invention provides a stable and reliable power source for the entire cefuroxime axetil pretreatment mechanism 3 by setting up a pretreatment drive assembly consisting of a pretreatment drive motor 37, a drive spindle 370, a first bevel gear 371, and a second bevel gear 372, resulting in high transmission efficiency. By setting up a recovery channel 38, an electric gate 380, and a recovery auger 39, the invention achieves automatic collection and recycling of substandard coarse powder, improving raw material utilization, reducing waste, realizing closed-loop management of the production process, and further ensuring that the particle size of the powder input to subsequent processes fully meets the preset requirements.

[0065] Example 4: Based on Example 1, a sweeping brush 320 is fixedly connected to the bottom of the grinding disc 32. Several grinding ball mounting grooves 321 are opened in the radial direction of the grinding disc 32. Grinding balls 322 are slidably connected in the grinding ball mounting grooves 321. The grinding balls 322 are connected to the inner wall of the grinding ball mounting grooves 321 through the reset elastic element 323.

[0066] The working principle and beneficial effects of the above technical solution are as follows: During the rotation of the grinding disc 32, the sweeping brush 320 can sweep the ground cefuroxime axetil powder into the screening chamber 35. At the same time, during the rotation of the grinding disc 32, the grinding balls 322 move outward under the action of centrifugal force, squeezing the cefuroxime axetil powder between the circumference of the grinding disc 32 and the inner wall of the grinding chamber 31, thereby assisting the grinding disc 32 to perform faster grinding.

[0067] This invention, by setting a sweeping brush 320 at the bottom of the grinding disc 32, can promptly sweep the ground powder into the screening chamber 35, preventing powder accumulation from affecting the grinding effect and equipment operation; by setting a grinding ball mounting groove 321, grinding balls 322 and a reset elastic element 323, when the grinding disc 32 rotates, the grinding balls 322 move outward under the action of centrifugal force, generating additional extrusion grinding force on the powder between the grinding disc 32 and the grinding chamber 31, forming a dynamic grinding pair, which significantly improves grinding efficiency and fineness, and makes the powder particle size more uniform.

[0068] Example 5: Based on Example 1, the mixing cylinder assembly 1 includes, from top to bottom, a hot melt mixing cylinder 10, a cooling granulation cylinder 11, and a cyclone screening cylinder 12. The hot melt mixing cylinder 10 is used to prepare cefuroxime axetil suspension, the cooling granulation cylinder 11 is used to prepare cefuroxime axetil coated microparticles, and the cyclone screening cylinder 12 is used to screen the cefuroxime axetil coated microparticles and input the qualified cefuroxime axetil coated microparticles into the mixing cylinder assembly 2.

[0069] The working principle and beneficial effects of the above technical solution are as follows: A predetermined mass of stearic acid and glyceryl monostearate are fed into the hot-melt mixing cylinder 10 from the top for melting. After the stearic acid and glyceryl monostearate have melted, a predetermined mass of povidone is added to the hot-melt mixing cylinder 10 and mixed evenly with the melted stearic acid and glyceryl monostearate. Then, cefuroxime axetil powder pretreated by the cefuroxime axetil pretreatment unit 3 is fed into the hot-melt mixing cylinder 10 via a centrifugal air compressor and mixed evenly with the remaining substances in the mixing cylinder assembly 1, ultimately forming a cefuroxime axetil suspension. The cefuroxime axetil suspension is cooled and granulated in the cooling granulation cylinder 11 to complete the coating, forming cefuroxime axetil coated microparticles. These microparticles then fall into the cyclone screening cylinder 12 for screening, and qualified cefuroxime axetil coated microparticles are fed into the mixing cylinder assembly 2.

[0070] This invention clearly divides the mixing cylinder assembly 1 into a functionally defined hot-melt mixing cylinder 10, a cooling granulation cylinder 11, and a cyclone screening cylinder 12. This modularizes and integrates the three core processes of suspension preparation, cooling granulation, and particle screening, ensuring close process connections, reducing pollution and losses caused by material transfer, and creating a compact spatial layout that optimizes equipment footprint and facilitates process control and maintenance. By setting the mixing cylinder assembly 1 as a series of sequentially connected hot-melt mixing cylinder 10, cooling granulation cylinder 11, and cyclone screening cylinder 12, continuous production of suspension preparation, cooling granulation primary products, and screening qualified primary products is achieved, greatly improving production efficiency.

[0071] Example 6: Based on Example 5, the hot melt mixing cylinder 10 is provided with a hot melt component and a mixing component. The hot melt component is used to hot melt the material input into the hot melt mixing cylinder 10, and the mixing component is used to stir the material input into the hot melt mixing cylinder 10.

[0072] The hot melt assembly includes a heating rod 100, which is installed in a medium heating chamber 101 inside the hot melt mixing cylinder 10. The medium heating chamber 101 is connected to a medium input pipe 102 and a medium output pipe 103 on the hot melt mixing cylinder 10.

[0073] The mixing assembly includes a mixing drive motor 104 mounted on a hot melt mixing cylinder 10. The output end of the mixing drive motor 104 is connected to a mixing shaft 105 via a coupling. The mixing shaft 105 is rotatably connected inside a mixing chamber 108. Several mixing stirring paddles 106 are fixedly connected to the mixing shaft 105. Several anti-sticking scrapers 107 are fixedly connected to the bottom of the mixing shaft 105. The output end of the mixing chamber 108 is connected to a cooling granulation cylinder 11 via a suspension output pipe 109.

[0074] The working principle and beneficial effects of the above technical solution are as follows: When the hot melt assembly is working, the heat exchange medium is input into the medium heating chamber 101 through the medium input pipe 102, and then the heating rod 100 is turned on, so that the heat exchange medium is heated to 75-85℃, which facilitates the melting of stearic acid and glyceryl monostearate.

[0075] When the mixing component is working, the mixing drive motor 104 drives the mixing shaft 105 to rotate, and the mixing shaft 105 drives the mixing agitator 106 and the anti-sticking scraper 107 to rotate, thereby achieving uniform mixing of the material. At the same time, the design of the anti-sticking scraper 107 can prevent the material near the bottom of the mixing chamber 108 from being continuously heated, thus preventing the cefuroxime axetil suspension from being overheated and failing.

[0076] This invention uses independent hot-melting and mixing components to precisely control the heating, melting, and mixing processes. The indirect heating method, with the heating rod 100 placed in the medium heating chamber 101, ensures uniform and gentle heating, avoiding localized overheating that could lead to drug failure. The mixing drive motor 104 drives the mixing shaft 105, mixing impeller 106, and anti-sticking scraper 107 to rotate, achieving thorough and uniform mixing of the materials. In particular, the design of the anti-sticking scraper 107 effectively removes the material adhering to the bottom of the mixing chamber 108, preventing the material from gelatinizing or denaturing due to prolonged heating, thus ensuring the quality and stability of the suspension.

[0077] Example 7: Based on Example 5, the cooling granulation cylinder 11 includes a cooling chamber 110 and a two-fluid airflow atomizer 111. The two-fluid airflow atomizer 111 is fixedly connected to the output end of the hot melt mixing cylinder 10. The two-fluid airflow atomizer 111 is used to atomize the cefuroxime axetil suspension into tiny droplets. After the droplets come into contact with the cooling medium in the cooling chamber 110, they are rapidly cooled and solidified to form the initial product of cefuroxime axetil coated microparticles.

[0078] The cooling chamber 110 is equipped with a cooling medium inlet pipe, a cooling medium outlet pipe, a gas distribution plate, and a cooling temperature sensor. The cooling medium inlet pipe is used to introduce cooling medium into the cooling chamber 110, and the cooling medium outlet pipe is used to export the cooling medium after heat exchange. The gas distribution plate is located at the output end of the cooling medium inlet pipe and is used to evenly distribute the cooling airflow to ensure that the atomized cefuroxime axetil suspension droplets are uniformly cooled and solidified during the cooling process. The cooling temperature sensor is used to monitor the temperature inside the cooling chamber 110 in real time to ensure that the cooling process is carried out within the preset temperature range.

[0079] The working principle and beneficial effects of the above technical solution are as follows: During operation, the cefuroxime axetil suspension from the hot melt mixing cylinder 10 first enters the two-fluid airflow atomizer 111. The two-fluid airflow atomizer 111 uses high-speed airflow to shear and atomize the viscous suspension into extremely small droplets, and sprays them into the cooling chamber 110.

[0080] Meanwhile, the cooling medium is continuously introduced into the cooling chamber 110 through the cooling medium inlet pipe. The cooling medium is such as low-temperature clean air or inert gas, such as nitrogen. After passing through the gas distribution plate, the cooling gas forms a uniform and stable upward airflow field. This low-temperature airflow comes into full contact with the atomized droplets falling from top to bottom, and instantaneous forced convection heat transfer is carried out. The heat in the droplets is quickly carried away, causing the molten coating material inside to cool and solidify rapidly. The molten coating material includes stearic acid, glyceryl monostearate, etc., which completely encapsulates the oral cefuroxime axetil powder inside, thereby forming a cefuroxime axetil coated microparticle primary product with uniform particle size and complete coating.

[0081] The cooling temperature sensor monitors the temperature inside the cooling chamber 110 in real time and feeds the signal back to the control system. By adjusting the flow rate or temperature of the cooling medium, the entire cooling and curing process is kept within a preset low temperature range, such as 2-8℃, to ensure coating quality and prevent drug degradation due to overheating.

[0082] By combining the two-fluid airflow atomizer 111 with the cooling chamber 110 equipped with a gas distribution plate, instantaneous atomization and uniform and controllable rapid cooling granulation of the material are achieved, resulting in concentrated particle size distribution, good sphericity, and dense and uniform coating of the coated particles, which greatly improves the consistency and stability of the dissolution behavior of the final dry suspension product.

[0083] This invention utilizes a two-fluid airflow atomizer 111 to atomize the suspension into tiny droplets, combined with a cooling chamber 110 equipped with a cooling medium inlet pipe, a cooling medium outlet pipe, a gas distribution plate, and a cooling temperature sensor. This achieves instantaneous atomization of the material and thorough, uniform, and controllable heat exchange with the cooling medium, resulting in rapid cooling and solidification. The formed coated microparticles exhibit a concentrated particle size distribution, good sphericity, and a dense and complete coating. Real-time monitoring and feedback control by the cooling temperature sensor ensures that the cooling process remains within the optimal temperature range, guaranteeing coating quality and effectively preventing drug degradation due to overheating. This significantly improves the consistency and stability of the dissolution behavior of the final dry suspension product.

[0084] Example 8: Based on Example 5, the cyclone screening cylinder 12 includes a discharge pipe 120, which is rotatably connected to the output end of the cooling granulation cylinder 11. A centrifugal screen 121 is fixedly connected to the end of the discharge pipe 120 away from the output end of the cooling granulation cylinder 11. The centrifugal screen 121 is sealed at the bottom by an arc-shaped cylinder 1210, which is rotatably connected to a mounting partition 122. The output end of the arc-shaped cylinder 1210 is connected to a recovery auger 1211. A screening drive motor 1290 is fixedly connected to the mounting partition 122. A screening drive gear 1291 is fixedly connected to the output end of 290, and a screening driven gear 1292 is fixedly connected to the arc-shaped cylinder 1210. The screening driven gear 1292 meshes with the screening drive gear 1291. An annular spray plate 1293 is fixedly connected to the cyclone screening cylinder 12. The annular spray plate 1293 is provided with several oblique spray holes 1294. One end of the oblique spray hole 1294 located outside the cyclone screening cylinder 12 is connected to a compressed air annular air supply pipe 1295. The compressed air annular air supply pipe 1295 is connected to the output end of an external air compressor.

[0085] A conical cylinder 124 is fixedly connected inside the cyclone screening cylinder 12 by several support rods 1231. A conical cylinder 2 123 is fixedly connected to the inner wall of the top of the cyclone screening cylinder 12. A negative pressure communication hole 1230 is opened behind the conical cylinder 2 123 for communicating with an external negative pressure generator. The conical cylinder 124 and the conical cylinder 2 123 are coaxial and the conical cylinder 2 123 is located inside the conical cylinder 124. The discharge pipe 120 passes through the conical cylinder 124 and the conical cylinder 2 123. A deflector plate mounting ring 125 is fixedly connected inside the conical cylinder 124. Several electric cyclone deflector plates 126 are rotatably connected to the deflector plate mounting ring 125.

[0086] An arc-shaped sweeping brush 127 is fixedly connected to the material drop pipe 120 inside the conical cylinder 124. The arc-shaped sweeping brush 127 fits in close contact with the inside of the annular bottom of the conical cylinder 124. The annular bottom of the conical cylinder 124 is connected to a discharge pipe 128, which is connected to the collection bin 129 below the mounting partition 122.

[0087] The working principle and beneficial effects of the above technical solution are as follows: During operation, the screening drive motor 1290 drives the screening drive gear 1291 to rotate, and the screening drive gear 1291 drives the screening driven gear 1292 to rotate, thereby driving the arc-shaped cylinder 1210, the centrifugal screen 121, and the discharge pipe 120 to rotate. The initial product of cefuroxime axetil coated microparticles falls into the arc-shaped cylinder 1210 through the discharge pipe 120. The initial product of cefuroxime axetil coated microparticles includes three types of coated microparticles: unqualified light cefuroxime axetil coated microparticles, qualified cefuroxime axetil coated microparticles, and unqualified... The high-quality heavy-quality cefuroxime axetil coated microparticles are not qualified. The unqualified heavy-quality cefuroxime axetil coated microparticles cannot pass through the centrifugal sieve 121 and remain inside the sieve, eventually being discharged via the recovery auger 1211. The unqualified light-quality cefuroxime axetil coated microparticles and the qualified cefuroxime axetil coated microparticles pass through the centrifugal sieve 121 under the combined action of centrifugal force and the screening by the centrifugal sieve 121. Simultaneously, an external air compressor inputs compressed air into the compressed air annular pipe 1295. The compressed air is guided by the oblique jet orifice 1294, changing the jet direction to an oblique angle. In the upward direction, both the substandard and qualified cefuroxime axetil coated microparticles move upward under the influence of the upward-sloping airflow. As they pass the electric cyclone deflector 126, they enter the conical cylinder 124 through the gap between adjacent electric cyclone deflectors 126. Guided by the electric cyclone deflectors 126, both the substandard and qualified cefuroxime axetil coated microparticles are redirected and rotate. During rotation, the microparticles are subjected to centrifugal force. The substandard cefuroxime axetil coated microparticles are less affected by centrifugal force and remain relatively stable under negative pressure. Under pressure, it continues to move upward into the conical cylinder 123 and is finally conveyed out of the cyclone screening cylinder 12 through the negative pressure connecting hole 1230. The qualified cefuroxime axetil coated microparticles are greatly affected by centrifugal force and will collide with the inner wall of the conical cylinder 124 and finally fall into the annular bottom of the conical cylinder 124. Since the discharge pipe 120 is in a rotating state, it drives the arc-shaped sweeping brush 127 to rotate. Thus, the qualified cefuroxime axetil coated microparticles will be swept into the discharge pipe 128 and finally enter the collection bin 129 through the discharge pipe 128, and finally fall into the mixing cylinder assembly 2 through the collection bin 129.

[0088] Among them, unqualified light cefuroxime axetil coated microparticles refer to cefuroxime axetil coated microparticles with a weight less than the minimum value of the preset weight range, qualified cefuroxime axetil coated microparticles refer to cefuroxime axetil coated microparticles with a weight within the preset weight range, and unqualified heavy cefuroxime axetil coated microparticles refer to cefuroxime axetil coated microparticles with a weight greater than the maximum value of the preset weight range.

[0089] Substandard light cefuroxime axetil coated microparticles typically include, but are not limited to, the following: microparticles with incomplete or excessively thin coatings resulting in exposed or excessively high proportions of the active pharmaceutical ingredient cefuroxime axetil; microparticles that fail to be effectively encapsulated by the coating material due to their small particle size during atomization and cooling; and empty capsules or fragments formed by the coating material itself.

[0090] Substandard heavy-duty cefuroxime axetil coated microparticles typically include, but are not limited to, the following: agglomerates formed by multiple coated microparticles adhering and fusing together; excessively thick coating layers due to excessively large atomized droplets or uneven cooling, or microparticles containing incompletely cooled and solidified cores; and coarse, irregular particles formed by dripping due to insufficient atomization.

[0091] This invention utilizes a primary centrifugal screening system comprised of a discharge pipe 120, a centrifugal screen 121, an arc-shaped cylinder 1210, a screening drive motor 1290, a screening drive gear 1291, and a screening driven gear 1292. It also includes an annular spray plate 1293, oblique spray holes 1294, an annular compressed air supply pipe 1295, a first conical cylinder 124, a second conical cylinder 123, a negative pressure connecting hole 1230, an electric cyclone deflector plate 126, an arc-shaped sweeping brush 127, a discharge pipe 128, and a collection bin. The precision air separation system consisting of 129 achieves efficient and precise three-stage separation of coated microparticles (unqualified heavy particles, qualified particles, and unqualified light particles). It has high separation efficiency and good accuracy. Through the ingenious combination of negative pressure and centrifugal force, it accurately separates particles of different weights. The qualified particle collection rate is high, and the automatic recycling and processing of unqualified particles is achieved through the recovery auger 1211 and the negative pressure outlet. The design of the arc-shaped sweeping brush 127 ensures that all qualified particles can be successfully collected into the collection bin 129, avoiding residue.

[0092] Example 9: Based on Example 1, the mixing cylinder assembly 2 includes a mixing cylinder mounting frame 20. The mixing cylinder mounting frame 20 is equipped with a mixing seasoning cylinder body 21 and a mixing seasoning drive motor 22. The output end of the mixing seasoning drive motor 22 is fixedly connected to a mixing seasoning stirring paddle 23. The top of the mixing seasoning cylinder body 21 is provided with a qualified cefuroxime axetil coated microparticle primary product inlet 24 and a seasoning inlet 25. The qualified cefuroxime axetil coated microparticle primary product inlet 24 is connected to the output end of the mixing cylinder assembly 1. The bottom of the mixing seasoning cylinder body 21 is provided with a dry suspension outlet 26.

[0093] The working principle and beneficial effects of the above technical solution are as follows: During operation, qualified cefuroxime axetil coated microparticles from mixing cylinder component 1 enter the mixing and seasoning cylinder 21 through the qualified cefuroxime axetil coated microparticle inlet 24. At the same time, the required sweeteners, flavorings, and suspending agents are added through the seasoning inlet 25 in a preset ratio. Among them, the sweeteners can be sucrose, honey, steviol glycosides, disodium glycyrrhizate, tripotassium glycyrrhizate, etc., the flavorings can be lemon, fennel, peppermint oil, cinnamon oil, etc., and the suspending agent is xanthan gum.

[0094] Start the mixing and seasoning drive motor 22, whose output end drives the mixing and seasoning stirring paddle 23 to rotate inside the mixing and seasoning cylinder 21. The rotation of the mixing and seasoning stirring paddle 23 will fully and gently mechanically stir and mix the qualified cefuroxime axetil coated microparticles and various excipients inside the mixing and seasoning cylinder 21. During this process, sweeteners and flavorings can be evenly attached to or penetrated into the surface and gaps of the coated microparticles, effectively improving the taste and flavor of the final product. At the same time, the suspending agent is also evenly mixed with other ingredients, ensuring that the dry suspension has good redispersibility and suspension stability when used.

[0095] This invention provides a dedicated mixing space for the flavoring and homogenization of the final product by setting up an independent mixing cylinder assembly 2, which includes a mixing cylinder mounting frame 20, a mixing and flavoring cylinder body 21, a mixing and flavoring drive motor 22, a mixing and flavoring stirring paddle 23, and a dedicated inlet 24 for qualified cefuroxime axetil coated microparticles and a flavoring inlet 25. Through the precise proportioning and addition of sweeteners, flavorings, and suspending agents, and under the gentle and efficient mechanical stirring of the mixing and flavoring stirring paddle 23, the excipients can be evenly attached to and penetrate into the surface and gaps of the coated microparticles, significantly improving the taste and flavor of the final product, increasing patient medication compliance, and ensuring the uniform distribution of the suspending agent, thus guaranteeing good redispersibility and suspension stability of the dry suspension during use.

[0096] Example 10: Based on Example 3, a mixing apparatus for the production of cefuroxime axetil further includes an online quality monitoring and feedback control system, which includes:

[0097] The particle size monitoring module is located at the output end of the screening chamber 35 and is used to monitor and output the particle size distribution signal of the pretreated cefuroxime axetil powder in real time.

[0098] The central processing unit is used to receive particle size distribution signals and compare the received signal values ​​with the internally preset standard value range;

[0099] The feedback actuator has its control input connected to the control signal output of the central processing unit. The feedback actuator includes a speed regulator for adjusting the speed of the pre-processing drive motor 37. When the received particle size distribution signal deviates from the preset standard value, the central processing unit outputs a control signal to the speed regulator to adjust the speed of the pre-processing drive motor 37, thereby changing the hammering and grinding intensity.

[0100] The working principle and beneficial effects of the above technical solution are as follows: During operation, the online quality monitoring feedback control system forms an efficient closed-loop control. The particle size monitoring module constantly checks the particle size distribution signal of the pre-treated product. When the laser particle size analyzer of the particle size monitoring module detects that the powder particle size is continuously too large, the central processing unit immediately judges that the current hammering or grinding intensity is insufficient. Subsequently, the central processing unit (PLC) outputs a command to the frequency converter speed controller to appropriately increase the speed of the pre-treatment drive motor 37, thereby accelerating the interaction frequency between the mating block 367 and the inclined mating ring 366, significantly increasing the up-and-down hammering frequency of the hammering cylinder 33. At the same time, the higher speed also directly increases the rotation speed of the grinding disc 32, enhancing the shearing and grinding force between it and the inner wall of the grinding chamber 31. It also allows the grinding balls 322 to obtain greater centrifugal force, further enhancing the grinding effect. Under this dual enhanced mechanical action, the crushing and grinding efficiency of the material is improved, ultimately bringing the output cefuroxime axetil powder particle size back to the preset range. Otherwise, the speed of the pre-treatment drive motor 37 is reduced.

[0101] The central processing unit sets a threshold N for the number of consecutive monitoring, for example, N=3 or 5. When the particle size value, such as the D90 value, detected by the laser particle size analyzer in N consecutive samplings all exceeds the upper limit of the preset range, it is determined to be "continuously too large".

[0102] Whenever the central processing unit determines that the particle size is continuously too large, the central processing unit sends a command to the variable frequency speed controller to increase the speed of the preprocessing drive motor 37 by a fixed step. Then the system waits for a period of time to observe the change in particle size. If the particle size is still too large, the fixed step is increased again. Conversely, when the particle size is continuously too small, the fixed step is decreased each time.

[0103] This invention achieves proactive and precise control over the particle size of pretreated powder by real-time monitoring of output and feedback adjustment of input. This ensures the uniformity and stability of material quality input into subsequent mixing and coating processes from the source, effectively avoiding final product quality problems caused by fluctuations in the pretreatment process, and significantly improving the reliability of the entire production system and the consistency of product quality.

[0104] Obviously, those skilled in the art can make various modifications and variations to this invention without departing from its spirit and scope. Therefore, if these modifications and variations fall within the scope of the claims of this invention and their equivalents, this invention also intends to include these modifications and variations.

Claims

1. A mixing apparatus for the production of cefuroxime axetil, characterized in that: The system includes a mixing cylinder assembly 1 (1), a mixing cylinder assembly 2 (2), and a cefuroxime axetil pretreatment mechanism (3). The output end of the mixing cylinder assembly 1 (1) is connected to the input end of the mixing cylinder assembly 2 (2). The mixing cylinder assembly 1 (1) is used to prepare qualified cefuroxime axetil coated microparticles. The mixing cylinder assembly 2 (2) is used to mix and flavor the qualified cefuroxime axetil coated microparticles to form the final product of cefuroxime axetil dry suspension. The output end of the cefuroxime axetil pretreatment mechanism (3) is connected to the input end of the mixing cylinder assembly 1 (1) and is used to hammer, grind, and screen the cefuroxime axetil powder to ensure that the particle size of the cefuroxime axetil powder input to the mixing cylinder assembly 1 (1) is within a preset range. The cefuroxime axetil pretreatment mechanism (3) includes a pretreatment cylinder (30), which is equipped with a hammering assembly, a grinding assembly and a screening assembly. The grinding assembly includes a grinding disc (32) rotatably connected in the grinding chamber (31). The grinding disc (32) cooperates with the inner wall of the grinding chamber (31) to grind the cefuroxime axetil powder. The hammering assembly includes a hammering cylinder (33) driven up and down and slidably connected in the pretreatment cylinder (30) by a reciprocating drive assembly. The hammering cylinder (33) is used to cooperate with the top surface of the grinding disc (32) to hammer the cefuroxime axetil powder. The screening assembly includes a screening stirring paddle (34) and a centrifugal air compressor. The screening stirring paddle (34) is rotatably connected in the screening chamber (35) of the pretreatment cylinder (30). The air inlet of the centrifugal air compressor is connected to the output end of the screening chamber (35), and the air outlet of the centrifugal air compressor is connected to the input end of the mixing cylinder assembly (1). The mixing cylinder assembly one (1) includes, from top to bottom, a hot melt mixing cylinder (10), a cooling granulation cylinder (11), and a cyclone screening cylinder (12). The hot melt mixing cylinder (10) is used to prepare cefuroxime axetil suspension, the cooling granulation cylinder (11) is used to prepare cefuroxime axetil coated microparticles, and the cyclone screening cylinder (12) is used to screen the cefuroxime axetil coated microparticles and input the qualified cefuroxime axetil coated microparticles into the mixing cylinder assembly two (2).

2. The mixing apparatus for the production of cefuroxime axetil according to claim 1, characterized in that: The reciprocating drive assembly includes a driven shaft (36) rotatably connected inside the pretreatment cylinder (30), the driven shaft (36) passing through the hammer cylinder (33), a grinding disc (32) fixedly connected to the driven shaft (36), a guide cap (360) fixedly connected to the driven shaft (36), a feed funnel (361) fixedly connected to the top of the pretreatment cylinder (30), and the guide cap (360) located directly below the feed funnel (361); The guide cap (360) has several initial material inlets (362) circumferentially. The inner wall of the guide cap (360) has an annular groove (363). The hammer cylinder (33) is fixedly connected to an annular slider (364). The annular slider (364) slides up and down in the annular groove (363). The bottom inner wall of the annular groove (363) is fixedly connected to a reset elastic element (365). The driven rotating shaft (36) is fixedly connected to a mating block (367). The inner wall of the hammer cylinder (33) is fixedly connected to a slope mating ring (366). The mating block (367) slides on the slope mating ring (366).

3. A mixing apparatus for the production of cefuroxime axetil according to claim 2, characterized in that: It also includes a pretreatment drive assembly, which includes a pretreatment drive motor (37). The pretreatment drive motor (37) is fixedly connected to the side wall of the pretreatment cylinder (30). The output end of the pretreatment drive motor (37) is connected to a drive spindle (370) via a coupling. A bevel gear one (371) is fixedly connected to the drive spindle (370), and a bevel gear two (372) is fixedly connected to the driven shaft (36). The bevel gear one (371) and the bevel gear two (372) mesh with each other. A recycling channel (38) is provided at the bottom of the screening chamber (35). An electric gate (380) is rotatably connected inside the recycling channel (38). The end of the recycling channel (38) away from the screening chamber (35) is connected to a recycling auger (39).

4. A mixing apparatus for the production of cefuroxime axetil according to claim 1, characterized in that: A scraping brush (320) is fixedly connected to the bottom of the grinding disc (32). Several grinding ball mounting grooves (321) are opened in the circumference of the grinding disc (32) along its radial direction. Grinding balls (322) are slidably connected in the grinding ball mounting grooves (321). The grinding balls (322) are connected to the inner wall of the grinding ball mounting grooves (321) through the second reset elastic element (323).

5. A mixing apparatus for the production of cefuroxime axetil according to claim 1, characterized in that: The hot melt mixing cylinder (10) is equipped with a hot melt component and a mixing component. The hot melt component is used to melt the material entering the hot melt mixing cylinder (10), and the mixing component is used to stir the material entering the hot melt mixing cylinder (10). The hot melt assembly includes a heating rod (100), which is installed in a medium heating chamber (101) inside a hot melt mixing cylinder (10). The medium heating chamber (101) is connected to a medium input pipe (102) and a medium output pipe (103) on the hot melt mixing cylinder (10). The mixing assembly includes a mixing drive motor (104) mounted on a hot melt mixing cylinder (10). The output end of the mixing drive motor (104) is connected to a mixing shaft (105) via a coupling. The mixing shaft (105) is rotatably connected inside the mixing chamber (108). Several mixing stirring paddles (106) are fixedly connected to the mixing shaft (105). Several anti-sticking scrapers (107) are fixedly connected to the bottom of the mixing shaft (105). The output end of the mixing chamber (108) is connected to the cooling granulation cylinder (11) via a suspension output pipe (109).

6. A mixing apparatus for the production of cefuroxime axetil according to claim 1, characterized in that: The cooling granulation cylinder (11) includes a cooling chamber (110) and a two-fluid airflow atomizer (111). The two-fluid airflow atomizer (111) is fixedly connected to the output end of the hot melt mixing cylinder (10). The two-fluid airflow atomizer (111) is used to atomize the cefuroxime axetil suspension into tiny droplets. After the droplets come into contact with the cooling medium in the cooling chamber (110), they are rapidly cooled and solidified to form the initial product of cefuroxime axetil coated microparticles. The cooling chamber (110) is equipped with a cooling medium inlet pipe, a cooling medium outlet pipe, a gas distribution plate and a cooling temperature sensor. The cooling medium inlet pipe is used to introduce cooling medium into the cooling chamber (110), and the cooling medium outlet pipe is used to export the cooling medium after heat exchange. The gas distribution plate is located at the output end of the cooling medium inlet pipe and is used to evenly distribute the cooling airflow to ensure that the atomized cefuroxime axetil suspension droplets are uniformly cooled and solidified during the cooling process. The cooling temperature sensor is used to monitor the temperature in the cooling chamber (110) in real time to ensure that the cooling process is carried out within the preset temperature range.

7. A mixing apparatus for the production of cefuroxime axetil according to claim 1, characterized in that: The cyclone screening cylinder (12) includes a discharge pipe (120), which is rotatably connected to the output end of the cooling granulation cylinder (11). A centrifugal screen (121) is fixedly connected to the end of the discharge pipe (120) away from the output end of the cooling granulation cylinder (11). The centrifugal screen (121) is sealed at the bottom by an arc-shaped cylinder (1210), which is rotatably connected to a mounting partition (122). The output end of the arc-shaped cylinder (1210) is connected to a recovery auger (1211). A screening drive motor (1290) is fixedly connected to the mounting partition (122). A screening drive gear (1291) is fixedly connected to the output end, and a screening driven gear (1292) is fixedly connected to the arc-shaped cylinder (1210). The screening driven gear (1292) meshes with the screening drive gear (1291). An annular spray plate (1293) is fixedly connected to the cyclone screening cylinder (12). The annular spray plate (1293) is provided with several oblique spray holes (1294). One end of the oblique spray hole (1294) located outside the cyclone screening cylinder (12) is connected to a compressed air annular air supply pipe (1295). The compressed air annular air supply pipe (1295) is connected to the output end of an external air compressor. A conical cylinder (124) is fixedly connected inside the cyclone screening cylinder (12) by several support rods (1231). A conical cylinder (123) is fixedly connected to the inner wall of the top of the cyclone screening cylinder (12). A negative pressure communication hole (1230) is opened behind the conical cylinder (123). The negative pressure communication hole (1230) is used to communicate with an external negative pressure generator. The conical cylinder (124) and the conical cylinder (123) are coaxial and the conical cylinder (123) is located inside the conical cylinder (124). The discharge pipe (120) passes through the conical cylinder (124) and the conical cylinder (123). A deflector plate mounting ring (125) is fixedly connected inside the conical cylinder (124). Several electric cyclone deflector plates (126) are rotatably connected to the deflector plate mounting ring (125). An arc-shaped sweeping brush (127) is fixedly connected to the material drop pipe (120) inside the conical cylinder (124). The arc-shaped sweeping brush (127) fits into the inside of the annular bottom of the conical cylinder (124). The annular bottom of the conical cylinder (124) is connected to the discharge pipe (128), which is connected to the collection bin (129) below the partition plate (122).

8. A mixing apparatus for the production of cefuroxime axetil according to claim 1, characterized in that: Mixing cylinder assembly 2 (2) includes a mixing cylinder mounting frame (20), on which a mixing seasoning cylinder body (21) and a mixing seasoning drive motor (22) are mounted. The output end of the mixing seasoning drive motor (22) is fixedly connected to a mixing seasoning stirring paddle (23). The top of the mixing seasoning cylinder body (21) is provided with a qualified cefuroxime axetil coated microparticle inlet (24) and a seasoning inlet (25). The qualified cefuroxime axetil coated microparticle inlet (24) is connected to the output end of the mixing cylinder assembly 1 (1). The bottom of the mixing seasoning cylinder body (21) is provided with a dry suspension outlet (26).

9. A mixing apparatus for the production of cefuroxime axetil according to claim 3, characterized in that: It also includes an online quality monitoring and feedback control system, which includes: The particle size monitoring module is set at the output end of the screening chamber (35) and is used to monitor and output the particle size distribution signal of the pretreated cefuroxime axetil powder in real time. The central processing unit is used to receive particle size distribution signals and compare the received signal values ​​with the internally preset standard value range; The feedback actuator has its control input end connected to the control signal output end of the central processing unit. The feedback actuator includes a speed regulator for adjusting the speed of the pre-processing drive motor (37). When the received particle size distribution signal deviates from the preset standard value, the central processing unit outputs a control signal to the speed regulator to adjust the speed of the pre-processing drive motor (37), thereby changing the hammering and grinding intensity.

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