Composition for improving vein dysfunction and preparation method thereof

Abstract

The invention relates to the technical field of biological medicines, in particular to a composition, a pharmaceutical composition containing the composition, a dietary supplement, preparation methods of the composition and the pharmaceutical composition and the dietary supplement, and application of the composition and the pharmaceutical composition to preparation of medicines.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of biological medicine, in particular to a composition, a pharmaceutical composition and a dietary supplement comprising the same, and a preparation method thereof and use thereof in the preparation of a pharmaceutical product. BACKGROUND

[0002] Venous insufficiency is a disease caused by the obstruction of venous blood return and the dysfunction of venous valves, which manifests as blood disorders, and further causes symptoms such as edema, tissue congestion and chronic inflammation. This condition not only brings local discomfort to patients, but also can cause a series of systemic health problems, such as lower extremity edema and hemorrhoids. One of the most obvious symptoms of venous insufficiency is lower extremity edema and heaviness, and if it is not effectively controlled for a long time, it can lead to chronic venous congestion, which manifests as persistent leg fatigue, pain and night cramps in patients. In addition, the symptoms of patients with venous insufficiency are aggravated when standing or sitting for a long time, and severe patients may develop varicose veins, pigmentation, and even chronic ulcers, which further affect the daily activities and quality of life of patients.

[0003] In addition to edema and heaviness, venous insufficiency can also cause skin itching, burning sensation, skin thinning, phlebitis and subcutaneous induration, and severe patients may even develop venous thrombosis, bringing more serious health risks. The existence of venous insufficiency greatly reduces the quality of life of patients, and some patients may develop psychological stress such as anxiety and depression due to long-term discomfort and limited activities, which adversely affects many aspects of daily life, social interaction, etc.

[0004] The treatment methods for venous insufficiency mainly include surgery and drug therapy. Although surgical treatment is effective, it is invasive, has a long recovery period, and is not suitable for all patients. Although external drugs can improve local symptoms, they are not convenient to use, and their effects mainly act on the surface, making it difficult to fundamentally improve venous function, and long-term dependence may cause skin problems, allergic reactions, etc. In addition, oral vasoactive drugs (such as flavonoids) are widely used in clinical practice to improve venous insufficiency, which can enhance venous wall elasticity, reduce inflammation, and improve blood circulation, and are suitable for the management of chronic venous disease. However, the efficacy of such drugs varies from individual to individual, and usually requires long-term administration to see results. In addition, they cannot completely reverse venous valve damage or severe varicose veins, and can only be used as an adjunctive therapy. Some patients may experience gastrointestinal discomfort, allergic reactions, or liver and kidney function damage, etc. At the same time, pregnant women, lactating women and some patients with chronic diseases need to use them under the guidance of a doctor, and they are not suitable for long-term use. Therefore, although vasoactive drugs can help alleviate symptoms, they still need to be combined with lifestyle adjustments, compression therapy or surgical intervention to achieve a more comprehensive treatment effect.

[0005] Also, the currently widely used flavonoid compounds and other extracts are expensive, the extraction efficiency is affected by the process, and other ingredients in the plants that are beneficial to the health of the veins are wasted, and in addition, environmental pollution can be caused. Based on this, using natural food to improve venous insufficiency is a feasible method based on the whole food approach. SUMMARY

[0006] The applicant of the present application provides a composition comprising natural food materials after a large number of experiments. The present application finds that the edible product (for example, a compound powder or a compound juice) prepared by mixing these food materials in a certain proportion can effectively improve the venous insufficiency of the subject.

[0007] Therefore, in a first aspect, the present application provides a composition comprising the following components: Lycium ruthenicum, Mentha, Purple Cabbage, Ginger, Purple Carrot, Cranberry, Strawberry, Purple Eggplant, Spinach, Broccoli, Purple Perilla, Beetroot, Red Bell Pepper, Cauliflower, White Carrot, Chinese Cabbage, Component B, and Component C; wherein,

[0008] Component B is selected from blueberry, blueberry, Meiyu, bilberry, or any combination thereof;

[0009] Component C is selected from orange, citrus, lemon, bergamot, or any combination thereof.

[0010] In certain embodiments, the composition comprises the following components: Lycium ruthenicum, Mentha, Purple Cabbage, Ginger, Purple Carrot, Cranberry, Strawberry, Purple Eggplant, Spinach, Broccoli, Purple Perilla, Beetroot, Red Bell Pepper, Cauliflower, White Carrot, Chinese Cabbage, Component A, Component B, and Component C; wherein,

[0011] Component A is selected from sophora, sophora flower, or any combination thereof;

[0012] Component B is selected from blueberry, blueberry, Meiyu, bilberry, or any combination thereof;

[0013] Component C is selected from orange, citrus, lemon, bergamot, or any combination thereof.

[0014] It should be understood that the physical form of each component in the compositions of the present application is not limited. Each component can be independently selected from any one or any combination of the following forms: whole fruit, cut pieces, ground particles, pulp, homogenate, and secondary forms such as concentrated liquid, dried powder, lyophilized powder, spray-dried granules, freeze-dried pieces, vacuum-dried pieces, and the like, which are derived from any of the above forms by conventional processes. In other words, as long as the composition contains the components as defined in the present application, it falls within the scope of the present application even if it is specifically presented in different physical forms. Therefore, the skilled person can select the form of any of the components according to the production, storage, transportation, consumption, or regulatory needs under the guidance of the disclosure of the present application.

[0015] In certain embodiments, the composition includes the following components: black wolfberry, mint, purple cabbage, ginger, purple carrot, cranberry, strawberry, purple eggplant, spinach, broccoli, purple shiso, beetroot, red bell pepper, garland chive, white carrot, bok choy, blueberry, and orange.

[0016] In certain embodiments, the composition includes the following components: black wolfberry, mint, purple cabbage, ginger, purple carrot, cranberry, strawberry, purple eggplant, spinach, broccoli, purple shiso, beetroot, red bell pepper, garland chive, white carrot, bok choy, blueberry, and lemon.

[0017] In certain embodiments, the composition includes the following components: black wolfberry, mint, purple cabbage, ginger, purple carrot, cranberry, strawberry, purple eggplant, spinach, broccoli, purple shiso, beetroot, red bell pepper, garland chive, white carrot, bok choy, locust flower, blueberry, and orange.

[0018] In certain embodiments, the composition includes the following components: black wolfberry, mint, purple cabbage, ginger, purple carrot, cranberry, strawberry, purple eggplant, spinach, broccoli, purple shiso, beetroot, red bell pepper, garland chive, white carrot, bok choy, locust flower, blueberry, and orange.

[0019] In certain embodiments, the composition includes the following components: black wolfberry, mint, purple cabbage, ginger, purple carrot, cranberry, strawberry, purple eggplant, spinach, broccoli, purple shiso, beetroot, red bell pepper, garland chive, white carrot, bok choy, locust flower, blueberry, and orange.

[0020] In certain embodiments, the composition includes the following components: black wolfberry, mint, purple cabbage, ginger, purple carrot, cranberry, strawberry, purple eggplant, spinach, broccoli, purple shiso, beetroot, red bell pepper, garland chive, white carrot, bok choy, locust flower, blueberry, and orange.

[0021] In the present disclosure, "black wolfberry" refers to Lycium ruthenicum Murr. "Purple carrot" refers to Daucus carota subsp. sativus, which is purple due to its high content of anthocyanin. "Beetroot" refers to the edible taproot of Beta vulgaris L. "Sophora flower" refers to the dried flowers and open inflorescences of Sophora japonica L. "Sophora bud" refers to the dried flower buds (not yet open) of Sophora japonica L. "Blue honeysuckle" is Lonicera caerulea. "Evergreen mei" refers to Aronia melanocarpa (Michx.) Elliott, also known as black chokeberry, black fruit, and black fruit Aronia melanocarpa (Michx.) Elliott. "Fingered citron" is also known as Buddha's hand and Citrus medica L. var. sarcodactylis.

[0022] The proportions and weight parts of the components in the composition of the present disclosure are not limited to the specific proportions and weight parts implemented in the examples, and those skilled in the art can appropriately adjust the proportions and weight parts of the components according to different conditions of the subjects. Of course, when the components in the composition of the present disclosure are used in the proportions and weight parts in the following embodiments, a better synergistic effect can be achieved.

[0023] In some embodiments, the composition comprises the following components in weight parts: black wolfberry 5-25 parts, mint 3-15 parts, purple cabbage 5-30 parts, ginger 5-15 parts, purple carrot 5-40 parts, cranberry 10-30 parts, strawberry 5-25 parts, purple eggplant 5-20 parts, spinach 5-30 parts, broccoli 5-30 parts, purple perilla 5-10 parts, beetroot 5-10 parts, red sweet pepper 5-30 parts, gai lan 5-10 parts, white carrot 5-10 parts, Chinese cabbage 5-30 parts, component A 5-30 parts, component B 10-60 parts, and component C 10-60 parts; wherein component B is selected from blueberry, blue honeysuckle, evergreen mei, bilberry, or any combination thereof; and component C is selected from orange, citrus, lemon, fingered citron, or any combination thereof.

[0024] In certain embodiments, the composition comprises the following components by weight parts: Lycium ruthenicum 15-20 parts, Mentha 5-10 parts, Purple Cabbage 10-15 parts, Ginger 5-10 parts, Purple Carrot 25-30 parts, Cranberry 15-20 parts, Strawberry 10-15 parts, Purple Eggplant 10-15 parts, Spinach 10-30 parts, Broccoli 5-25 parts, Purple Perilla 5-10 parts, Beetroot 5-10 parts, Red Bell Pepper 10-25 parts, Gai La 5-10 parts, White Radish 5-10 parts, Chinese Cabbage 5-30 parts, Component A 10-15 parts, Component B 35-45 parts, Component C 25-35 parts; wherein Component B is selected from Blueberry, Bilberry, Prunus virginiana, Lingonberry, or any combination thereof; and Component C is selected from Orange, Citrus, Lemon, Bergamot, or any combination thereof.

[0025] In certain embodiments, the composition comprises the following components by weight parts: Lycium ruthenicum 5-25 parts, Mentha 3-15 parts, Purple Cabbage 5-30 parts, Ginger 5-15 parts, Purple Carrot 5-40 parts, Cranberry 10-30 parts, Strawberry 5-25 parts, Purple Eggplant 5-20 parts, Spinach 5-30 parts, Broccoli 5-30 parts, Purple Perilla 5-10 parts, Beetroot 5-10 parts, Red Bell Pepper 5-30 parts, Gai La 5-10 parts, White Radish 5-10 parts, Chinese Cabbage 5-30 parts, Component A 5-30 parts, Component B 10-60 parts, Component C 10-60 parts; wherein Component A is selected from Sophora japonica, Sophora flower, or any combination thereof; Component B is selected from Blueberry, Bilberry, Prunus virginiana, Lingonberry, or any combination thereof; and Component C is selected from Orange, Citrus, Lemon, Bergamot, or any combination thereof.

[0026] In certain embodiments, the composition comprises the following components by weight parts: Lycium ruthenicum 15-20 parts, Mentha 5-10 parts, Purple Cabbage 10-15 parts, Ginger 5-10 parts, Purple Carrot 25-30 parts, Cranberry 15-20 parts, Strawberry 10-15 parts, Purple Eggplant 10-15 parts, Spinach 10-30 parts, Broccoli 5-25 parts, Purple Perilla 5-10 parts, Beetroot 5-10 parts, Red Bell Pepper 10-25 parts, Gai La 5-10 parts, White Radish 5-10 parts, Chinese Cabbage 5-30 parts, Component A 10-15 parts, Component B 35-45 parts, Component C 25-35 parts; wherein Component A is selected from Sophora japonica, Sophora flower, or any combination thereof; Component B is selected from Blueberry, Bilberry, Prunus virginiana, Lingonberry, or any combination thereof; and Component C is selected from Orange, Citrus, Lemon, Bergamot, or any combination thereof.

[0027] In certain embodiments, the composition comprises, in parts by weight: Lycium ruthenicum 5-25, Mentha 3-15, Purple Cabbage 5-30, Ginger 5-15, Purple Carrot 5-40, Cranberry 10-30, Strawberry 5-25, Purple Eggplant 5-20, Spinach 5-30, Broccoli 5-30, Perilla 5-10, Beetroot 5-10, Red Bell Pepper 5-30, Endive 5-10, White Radish 5-10, Bok Choy 5-30, Blueberry 10-60, Orange 10-60.

[0028] In certain embodiments, the composition comprises, in parts by weight: Lycium ruthenicum 15-20, Mentha 5-10, Purple Cabbage 10-15, Ginger 5-10, Purple Carrot 25-30, Cranberry 15-20, Strawberry 10-15, Purple Eggplant 10-15, Spinach 10-30, Broccoli 5-25, Perilla 5-10, Beetroot 5-10, Red Bell Pepper 10-25, Endive 5-10, White Radish 5-10, Bok Choy 5-30, Blueberry 35-45, Orange 25-35.

[0029] In certain embodiments, the composition comprises, in parts by weight: Lycium ruthenicum 5-25, Mentha 3-15, Purple Cabbage 5-30, Ginger 5-15, Purple Carrot 5-40, Cranberry 10-30, Strawberry 5-25, Purple Eggplant 5-20, Spinach 5-30, Broccoli 5-30, Perilla 5-10, Beetroot 5-10, Red Bell Pepper 5-30, Endive 5-10, White Radish 5-10, Bok Choy 5-30, Sophora or Sophora Flower 5-30, Blueberry 10-60, Orange 10-60.

[0030] In certain embodiments, the composition comprises, in parts by weight: Lycium ruthenicum 15-20, Mentha 5-10, Purple Cabbage 10-15, Ginger 5-10, Purple Carrot 25-30, Cranberry 15-20, Strawberry 10-15, Purple Eggplant 10-15, Spinach 10-30, Broccoli 5-25, Perilla 5-10, Beetroot 5-10, Red Bell Pepper 10-25, Endive 5-10, White Radish 5-10, Bok Choy 5-30, Sophora or Sophora Flower 10-15, Blueberry 35-45, Orange 25-35.

[0031] In a further aspect, the present application provides a pharmaceutical composition comprising the composition as described above.

[0032] In certain embodiments, the pharmaceutical composition further comprises an additional active ingredient.

[0033] In certain embodiments, the additional active ingredient is capable of treating and / or ameliorating a disease and / or a symptom (e.g., heaviness in the lower extremities, swelling in the lower extremities, skin pigmentation, skin burning, skin itching, hemorrhoids, muscle cramps, muscle spasms, varicose veins, venous ulcers) associated with (e.g., caused or induced by) venous insufficiency in the subject.

[0034] In certain embodiments, the additional active ingredient is selected from the group consisting of flavonoids, polyphenols, saponins, terpenoids (e.g., triterpenoids), alkaloids (e.g., solasodine), organosulfides (e.g., thioglucosides), coumarins (e.g., coumarin), polysaccharides (e.g., polysaccharide from Lycium barbarum), phenolic acids (e.g., phenylpropanoic acid), metal ions, vitamins, coenzymes, or any combination thereof.

[0035] In certain embodiments, the additional active ingredient is selected from the group consisting of troxerutin, rutin, diosmin, quercetin, hesperidin, β-escin, menthol, asiaticoside, berberine, magnesium ion, vitamin C, coenzyme Q10, or any combination thereof.

[0036] In certain embodiments, the pharmaceutical composition further comprises a pharmaceutically acceptable carrier and / or excipient.

[0037] In certain embodiments, the pharmaceutical composition is in the form of a solution, a suspension, a powder, a tablet, a pill, an emulsion, a gel, a capsule, a granule, an elixir, a lozenge, a suppository, an injection, an inhalant, or a spray.

[0038] In a further aspect, the present application provides a dietary supplement comprising the composition as described above.

[0039] In certain embodiments, the dietary supplement further comprises an additional adjuvant.

[0040] In certain embodiments, the additional adjuvant is selected from the group consisting of a food additive, a food processing aid, a nutritional fortifier.

[0041] In certain embodiments, the food additive is selected from the group consisting of a sweetener, an acidity regulator, a food flavoring.

[0042] In certain embodiments, the additional adjuvant is selected from the group consisting of honey, xylitol, erythritol, citric acid, DL-malic acid, pectin, maltodextrin, resistant dextrin, vitamin C, vitamin E, calcium, iron, zinc, or any combination thereof.

[0043] In certain embodiments, the dietary supplement is selected from the group consisting of baked goods, extruded goods, puffed goods, and baked goods.

[0044] In certain embodiments, the dietary supplement is selected from the group consisting of solid beverages, lyophilized blocks, confections, and liquid beverages (e.g., ready-to-drink juices, concentrated juices).

[0045] It should be understood that the dietary supplement of the present application is not limited by its final physical form or manner of processing. One skilled in the art can choose any form or manner to present the dietary supplement of the present application as desired.

[0046] In another aspect, the present application provides a method for preparing a pharmaceutical composition as described above or a dietary supplement as described above, comprising:

[0047] (1) providing a composition as described above;

[0048] (2) freeze-drying the composition.

[0049] In certain embodiments, the form of the components in the composition is a cut piece or a crumb.

[0050] In certain embodiments, the method further comprises: further preparing the product obtained in (2) into a powdered product.

[0051] In another aspect, the present application provides a method for preparing a pharmaceutical composition as described above or a dietary supplement as described above, comprising:

[0052] (1) providing a composition as described above;

[0053] (2) freeze-drying the composition.

[0054] In certain embodiments, the form of the components in the composition is a slurry or a homogenate.

[0055] In certain embodiments, the method further comprises: further preparing the product obtained in (2) into a block product.

[0056] In certain embodiments, the method further comprises: reconstituting the block product obtained into a liquid.

[0057] In certain embodiments, the method further comprises: forming a flavored coating (e.g., chocolate, honey, natural spices, or any combination thereof) on the outer surface of the block product obtained.

[0058] In another aspect, the present application provides a method for preparing a pharmaceutical composition as described above or a dietary supplement as described above, comprising:

[0059] (1) providing the composition as described above;

[0060] (2) subjecting the composition to juicing process.

[0061] In a further aspect, the present application provides use of the composition as described above or the pharmaceutical composition as described above or the dietary supplement as described above in the preparation of a medicament for treating and / or ameliorating a disease and / or a symptom associated with venous insufficiency in a subject.

[0062] In certain embodiments, the disease and / or the symptom is a disease and / or a symptom caused or induced by venous insufficiency, for example, heaviness in lower extremities, swelling in lower extremities, skin pigmentation, skin burning, skin itching, hemorrhoids, muscle cramp, muscle spasm, varicose veins, venous ulcer.

[0063] In certain embodiments, the disease and / or the symptom is selected from the group consisting of heaviness in lower extremities, swelling in lower extremities, skin pigmentation, skin burning, skin itching, hemorrhoids, muscle cramp, muscle spasm, varicose veins, venous ulcer, or any combination thereof.

[0064] In certain embodiments, the subject is a mammal.

[0065] In certain embodiments, the mammal is selected from the group consisting of mouse, pig, rabbit, monkey, sheep, human.

[0066] In a further aspect, the present application provides a method of treating and / or ameliorating a disease and / or a symptom associated with venous insufficiency in a subject, the method comprising administering to the subject an effective amount of the composition as described above or the pharmaceutical composition as described above or the dietary supplement as described above.

[0067] In certain embodiments, the disease and / or the symptom is selected from the group consisting of heaviness in lower extremities, swelling in lower extremities, skin pigmentation, skin burning, skin itching, hemorrhoids, muscle cramp, muscle spasm, varicose veins, venous ulcer, or any combination thereof.

[0068] In certain embodiments, the composition as described above or the pharmaceutical composition as described above or the dietary supplement as described above is administered to the subject continuously for 3 days, 5 days, 7 days, 10 days, 12 days, 15 days, 17 days, 20 days, or more.

[0069] In certain embodiments, the composition as described above or the pharmaceutical composition as described above or the dietary supplement as described above is administered to the subject 1 time, 2 times, 3 times, or more times per day.

[0070] In certain embodiments, the composition as described above or the pharmaceutical composition as described above or the dietary supplement as described above is administered to the subject orally.

[0071] In certain embodiments, the subject is a mammal.

[0072] In certain embodiments, the mammal is selected from the group consisting of a mouse, a pig, a rabbit, a monkey, a sheep, a human.

[0073] In certain embodiments, the method further comprises administering to the subject a second therapeutic agent or procedure.

[0074] In certain embodiments, the second therapeutic agent comprises an intravenously active drug, an anticoagulant, an anti-inflammatory analgesic, or a sclerosing agent.

[0075] In certain embodiments, the procedure comprises surgery, gradient pressure therapy, sclerotherapy, or palliative therapy.

[0076] Definitions of Terms

[0077] To further clarify the components of the compositions of the present application, the following components are further described.

[0078] As used herein, the term "Venous Insufficiency" is a pathological state. Specifically, it refers to a pathological state in which the venous system (including superficial veins, deep veins, and perforator veins) fails to return blood to the heart efficiently due to valve insufficiency and / or structural abnormalities of the venous wall, resulting in persistent or intermittent venous hypertension, blood stasis, and a series of clinical symptoms and / or signs. Chronic Venous Insufficiency (CVI) is a chronic stage of venous insufficiency, in which lower extremity edema, skin trophic changes (pigmentation, lipodermatosclerosis, eczema), venous ulcers, or healed ulcer scars generally appear. Studies have shown that venous insufficiency and chronic venous insufficiency can cause a variety of diseases and symptoms, including but not limited to lower extremity heaviness, lower extremity swelling, skin pigmentation, skin burning, skin itching, hemorrhoids, muscle cramps, muscle spasms, varicose veins, venous ulcers. In certain embodiments, the compositions of the present application are used to treat and / or improve chronic venous insufficiency in a subject.

[0079] As used herein, the term "pharmaceutically acceptable carrier and / or excipient" refers to a carrier and / or excipient that is compatible, philosophically and / or physiologically, with the subject and the active ingredient, is well known in the art, and includes, but is not limited to, pH adjusting agents, surfactants, adjuvants, ionic strength enhancers, diluents, agents to maintain osmotic pressure, agents to retard absorption, preservatives. For example, pH adjusting agents include, but are not limited to, phosphate buffers. Surfactants include, but are not limited to, cationic, anionic or non-ionic surfactants, such as Tween-80. Ionic strength enhancers include, but are not limited to, sodium chloride. Preservatives include, but are not limited to, various antibacterial and antifungal agents such as parabens, chlorobutanol, phenol, sorbic acid and the like. Agents to maintain osmotic pressure include, but are not limited to, sugars, NaCl. Agents to retard absorption include, but are not limited to, monostearate and gelatin. Diluents include, but are not limited to, water, aqueous buffers (such as buffered saline), alcohols and polyols (such as glycerin) and the like. Preservatives include, but are not limited to, various antibacterial and antifungal agents such as thiomersal, 2-phenoxyethanol, parabens, chlorobutanol, phenol, sorbic acid and the like. Stabilizers have the meaning commonly understood by those skilled in the art as being capable of stabilizing the desired activity of the active ingredient in the pharmaceutical, including, but not limited to, sodium glutamate, gelatin, SPGA, sugars (such as sorbitol, mannitol, starch, sucrose, lactose, dextran, or glucose), amino acids (such as glutamic acid, glycine), proteins (such as dried lactoserum, albumin or casein) or degradation products thereof (such as lactalbumin hydrolysate) and the like.

[0080] As used herein, the term "subject" refers to a mammal, such as a human, cynomolgus monkey, mouse, pig, rabbit, sheep. In certain embodiments, the subject is afflicted with a disease and / or symptoms associated with venous insufficiency, or, is at risk of having the disease.

[0081] As used herein, the term "treatment" refers to an approach undertaken for the purpose of obtaining a beneficial or desired clinical result. For the purposes of this application, beneficial or desired clinical results include, but are not limited to, alleviation of symptoms, diminishment of extent of disease, stabilization (i.e., not worsening) of the state of disease, delay or slowing of disease progression, amelioration or palliation of the disease state, remission (whether partial or total), whether or not detectable to the patient, and / or improved prognosis. Further, "treatment" can also mean prolonging survival as compared to expected survival if not receiving treatment.

[0082] Advantages of the Invention

[0083] The applicant of the present application provides a synergistic composition comprising natural food materials through a large number of experiments. The present application finds that the composition can effectively improve venous insufficiency of a subject by mixing the food materials in a certain proportion. For example, the composition of the present application can effectively relieve symptoms such as lower extremity venous reflux disorder, edema, leg heaviness and pain, pigmentation, skin burning and itching, and hemorrhoids. At the same time, the composition of the present application also has the effects of promoting blood circulation, reducing venous inflammation, and shortening the healing time of venous ulcers. Moreover, the composition of the present application has a very fast effect, and has a therapeutic effect in 1 day, and a significant therapeutic effect in 5-7 days.

[0084] In summary, the composition of the present application is based on whole food therapy, and has the advantages of pure naturalness, no additives, no toxic side effects, easy to use, and fast effect.

[0085] The embodiments of the present application will be described in detail below with reference to the examples, but those skilled in the art will understand that the following examples are only used to illustrate the present application, and are not intended to limit the scope of the present application. According to the following detailed description of the preferred embodiments, various objects and advantages of the present application will become apparent to those skilled in the art. DETAILED DESCRIPTION

[0086] The present application will now be described with reference to the following examples, which are intended to illustrate the present application (but not to limit the present application).

[0087] Unless specifically indicated otherwise, the experiments and methods described in the examples are carried out essentially according to the conventional methods well known in the art and described in various references.

[0088] In addition, the specific conditions are not indicated in the examples, and are carried out according to the conventional conditions or the conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products that can be obtained by purchase. Those skilled in the art know that the examples describe the present application by way of example, and are not intended to limit the scope of the present application claimed. All publications and other references mentioned herein are incorporated by reference in their entirety.

[0089] Example 1. Materials and Experimental Methods

[0090] 1.1 The following raw materials are involved in the formula of the composition of the present application: sophora flower (or sophora flower), black wolfberry, mint, purple cabbage, ginger, purple carrot, blueberry (or blue fruit, Mei, lingonberry), cranberry, strawberry, orange (or citrus, lemon, bergamot), purple eggplant, spinach, broccoli, purple perilla, beetroot, red sweet pepper, garland chrysanthemum, white radish, and Chinese cabbage. These are all commercially available materials.

[0091] 1.2 Treatment method of the composition:

[0092] (1) Preparation as a composite powder

[0093] Specifically including: cleaning the selected raw materials and cutting them into 1-2 cm blocks; drying the cut blocks through a vacuum freeze-drying device, with a vacuum degree of 10-50 Pa and a temperature not exceeding 60°C; then grinding the dried blocks into fine powder through a low-temperature grinding device; and mixing to obtain a composite powder.

[0094] (2) Preparation as a composite juice

[0095] Specifically including: cleaning and cutting the selected raw materials; juicing the raw materials through a juicing device to prepare a ready-to-drink juice or mixing with water in a certain proportion to make juice.

[0096] 1.3 Index evaluation method

[0097] (1) The pain visual analogue scale used in this paper is also known as visual analogue pain score (VAS, Visual Analogue Scale), which is an internationally recognized pain intensity scoring tool and is widely used in clinical trials. VAS consists of a 10 cm straight line, one end of which is marked as 0 indicating "completely painless", and the other end is marked as 10 indicating "pain to the extreme". Patients mark their own perceived pain intensity on the straight line, and measure the distance from the starting point (0 points) to the patient's marked point with a ruler (unit: cm), and convert it to 0-10 points.

[0098] (2) The pigmentation VCSS score used in this paper is based on the venous clinical severity score (VCSS) system. 0 points indicate "no venous pigmentation of the leg skin", 1 point indicates "pigmentation is limited to the ankle area (medial malleolus or lateral malleolus)", 2 points indicate "pigmentation is widely distributed in the lower third of the calf area", and 3 points indicate "pigmentation exceeds the lower third of the calf area".

[0099] (3) The edema score used in this paper is the Pitting Edema Scale. Grade 0: No clinically visible edema. Grade 1 (mild): Pitting depth: about 2 millimeters (mm). Grade 2 (moderate): Pitting depth: about 3-4 millimeters (mm). Grade 3 (severe): Pitting depth: about 5-6 millimeters (mm). Grade 4 (extremely severe): Pitting depth: about 8 millimeters (mm) or deeper.

[0100] (4) Constipation Wexner score used herein is evaluated by a professional through a scale to evaluate the defecation function and severity of constipation of a patient. The scale includes 8 items, namely defecation frequency, time for each defecation, pain assessment, auxiliary form, integrity, number of 24-hour defecation failures, abdominal pain and medical history. The total score is 30, and a score of 15 or more can be defined as constipation, and the higher the score, the more severe the constipation.

[0101] Example 2.

[0102] Patient information: 56-year-old male, long-term standing work, lower extremity varicose veins obvious, strong sense of leg heaviness, pain, afternoon edema aggravation.

[0103] Treatment formula 1: 10 parts by weight of sophora, 15 parts by weight of black medlar, 5 parts by weight of mint, 10 parts by weight of purple cabbage, 8 parts by weight of ginger, 25 parts by weight of purple carrot, 40 parts by weight of blueberry, 15 parts by weight of cranberry, 10 parts by weight of strawberry, 30 parts by weight of orange, 10 parts by weight of purple eggplant, 20 parts by weight of spinach, 10 parts by weight of broccoli, 5 parts by weight of perilla, 5 parts by weight of beetroot, 20 parts by weight of red sweet pepper, 6 parts by weight of gai lan, 5 parts by weight of white radish, 20 parts by weight of cabbage.

[0104] Formula form: compound powder.

[0105] Effect: After 3 days of taking, the afternoon edema is relieved; after 10 days of continuous taking, the leg heaviness is reduced, the pain is obviously reduced, and the standing tolerance is improved.

[0106] Treatment formula 2: compared with treatment formula 1, only sophora (or sophora flower) is missing, and the rest of the formula components and parts are the same.

[0107] Specifically contains: 15 parts by weight of black medlar, 5 parts by weight of mint, 10 parts by weight of purple cabbage, 8 parts by weight of ginger, 25 parts by weight of purple carrot, 40 parts by weight of blueberry, 15 parts by weight of cranberry, 10 parts by weight of strawberry, 30 parts by weight of orange, 10 parts by weight of purple eggplant, 20 parts by weight of spinach, 10 parts by weight of broccoli, 5 parts by weight of perilla, 5 parts by weight of beetroot, 20 parts by weight of red sweet pepper, 6 parts by weight of gai lan, 5 parts by weight of white radish, 20 parts by weight of cabbage.

[0108] Formula form: compound powder.

[0109] Effect: 3 days of lower extremity edema are relieved; to 10 days of heaviness reduction, pain is slightly reduced, and standing tolerance is improved to a certain extent.

[0110] Treatment formula 3: compared with treatment formula 1, only sophora is contained.

[0111] Formula form: powder.

[0112] Effect: 1-5 days, 10 parts by weight per day. After 5 days, increase to 20 parts by weight, and basically no effect after taking.

[0113] Further, according to the method of Example 1.3, the patient's condition after taking the above for 10 days is scored, and in order to avoid interference during the experiment, the interval between the use of the treatment formula is 1 month, and the specific effect is shown in Tables 1.1 and 1.2.

[0114] Table 1.1 Patient Condition

[0115]

[0116] Table 1.2 Patient's Calf Circumference

[0117]

[0118]

[0119] From the above results, it can be seen that the composition of the present application, i.e. treatment formula 1 and treatment formula 2, can effectively relieve lower extremity venous reflux, reduce edema, relieve leg heaviness and pain. And, the effect is fast, 3 days can produce visible effect, 10 days can produce significant effect. And, the effect of treatment formula 1 is the best, and treatment formula 3 containing only sophora fruit has no therapeutic effect. This shows that the components of the composition of the present application have a synergistic effect.

[0120] Example 3.

[0121] Patient information: 39-year-old female, office sedentary, both legs with poor venous return, prone to swelling and pain, and occasional calf edema.

[0122] Treatment formula 1: sophora fruit 10 parts by weight, black medlar 15 parts by weight, mint 5 parts by weight, purple cabbage 10 parts by weight, ginger 8 parts by weight, purple carrot 25 parts by weight, blueberry 40 parts by weight, cranberry 15 parts by weight, strawberry 10 parts by weight, orange 30 parts by weight, purple eggplant 10 parts by weight, spinach 15 parts by weight, broccoli 20 parts by weight, purple perilla 6 parts by weight, beetroot 6 parts by weight, red sweet pepper 25 parts by weight, gai lan 7 parts by weight, white radish 8 parts by weight, and cabbage 15 parts by weight.

[0123] Formula form: compound powder.

[0124] Effect: continuous taking for 7 days, leg swelling and pain are significantly relieved, discomfort after sitting is reduced, and calf edema frequency is reduced.

[0125] Treatment formula 2: compared with treatment formula 1, only sophora fruit (or sophora flower) is missing, and the rest of the formula components and parts are the same.

[0126] Specifically comprising: black wolfberry 15 parts by weight, mint 5 parts by weight, purple cabbage 10 parts by weight, ginger 8 parts by weight, purple carrot 25 parts by weight, blueberry 40 parts by weight, cranberry 15 parts by weight, strawberry 10 parts by weight, orange 30 parts by weight, purple eggplant 10 parts by weight, spinach 15 parts by weight, broccoli 20 parts by weight, purple perilla 6 parts by weight, beetroot 6 parts by weight, red sweet pepper 25 parts by weight, chard 7 parts by weight, white radish 8 parts by weight, and Chinese cabbage 15 parts by weight.

[0127] Form: Compound powder.

[0128] Effect: Slight improvement in swelling and pain, slight improvement in edema, and certain relief of discomfort after prolonged sitting.

[0129] Treatment Formula 3: Compared with Treatment Formula 1, only containing sophora.

[0130] Form: Powder.

[0131] Effect: 10 parts by weight per day for 1-3 days, increased to 20 parts by weight after 3 days, and basically no effect.

[0132] Further, according to the method of Example 1.3, the condition of the patient after taking the above-mentioned for 7 days is scored, and in order to avoid interference in the experiment, the interval time between the use of treatment formulas is 1 month, and the specific effect is shown in Table 2.1 and Table 2.2.

[0133] Table 2.1 Patient Condition

[0134]

[0135] Table 2.2 Patient Calf Circumference

[0136] Circumference of the lower leg at the highest point (before use, cm) Circumference of the lower leg at the highest point (after use, cm) Treatment Formulation 1 40.5 35.5 Treatment Formulation 2 40 37.7 Treatment Formulation 3 40 39.6

[0137] From the above results, it can be seen that the composition of the present application, i.e. Treatment Formula 1 and Treatment Formula 2, can effectively relieve lower extremity venous reflux disorder, reduce edema, and relieve leg heaviness and pain. Moreover, the effect of Treatment Formula 1 is particularly significant. The treatment effect of Formula 2 is much better than that of Treatment Formula 3, and slightly worse than that of Treatment Formula 1. Treatment Formula 3 containing only sophora has no treatment effect (Table 2). This further illustrates that the components of the composition of the present application have a synergistic effect.

[0138] Example 4.

[0139] Patient information: A 45-year-old male with chronic venous insufficiency for a long time, with pigmentation on the lower leg skin and occasional dull pain in the leg.

[0140] Treatment Formula 1: Sophora japonica 10 parts by weight, Lycium ruthenicum 15 parts by weight, Mentha 5 parts by weight, Purple Cabbage 10 parts by weight, Ginger 8 parts by weight, Purple Carrot 25 parts by weight, Blueberry 40 parts by weight, Cranberry 15 parts by weight, Strawberry 10 parts by weight, Orange 30 parts by weight, Purple Eggplant 10 parts by weight, Spinach 25 parts by weight, Broccoli 15 parts by weight, Purple Perilla 7 parts by weight, Beetroot 8 parts by weight, Red Bell Pepper 10 parts by weight, Gai Lan 5 parts by weight, White Radish 7 parts by weight, Chinese Cabbage 10 parts by weight.

[0141] Formula Form: Compound Powder.

[0142] Effect: After 5 days of taking, the leg pain is reduced, and the skin color is gradually improved; after 15 days of continuous taking, the leg comfort is improved.

[0143] Treatment Formula 2: Lycium ruthenicum 15 parts by weight, Mentha 5 parts by weight, Purple Cabbage 10 parts by weight, Ginger 8 parts by weight, Purple Carrot 25 parts by weight, Blueberry 40 parts by weight, Cranberry 15 parts by weight, Strawberry 10 parts by weight, Orange 30 parts by weight, Purple Eggplant 10 parts by weight, Spinach 25 parts by weight, Broccoli 15 parts by weight, Purple Perilla 7 parts by weight, Beetroot 8 parts by weight, Red Bell Pepper 10 parts by weight, Gai Lan 5 parts by weight, White Radish 7 parts by weight, Chinese Cabbage 10 parts by weight.

[0144] Formula Form: Compound Powder.

[0145] Effect: After 5 days of taking, the leg pain is reduced, and the skin color is gradually improved; after 15 days of continuous taking, the leg comfort is improved.

[0146] Treatment Formula 3: Compared with Treatment Formula 1, only contains Sophora japonica.

[0147] Formula Form: Powder.

[0148] Effect: 1-5 days per day Sophora japonica 10 parts by weight, after 5 days of use, change to 20 parts by weight. Basically ineffective.

[0149] Further, according to the method of Example 1.3, the condition of the patient after taking for 15 days is scored, in order to avoid interference in the experiment, the interval time between the treatment formulas is 1 month, and the specific effect is shown in Table 3.

[0150] Table 3. Patient Condition

[0151]

[0152] From the above results, it can be seen that the compositions of the present application, i.e. Treatment Formula 1 and Treatment Formula 2, not only effectively alleviate the lower extremity venous reflux disorder, leg heaviness and pain, but also effectively alleviate the pigmentation of patients with severe symptoms. Moreover, the effect is fast, and visible results can be produced in 5 days. Moreover, the treatment effect of Treatment Formula 1 is particularly significant, and the effect of Treatment Formula 2 is slightly lower than that of Treatment Formula 1, but both are significantly stronger than that of Treatment Formula 3; Treatment Formula 3 containing only sophora fruit has no treatment effect (Table 3). This shows that the components of the composition of the present application have a synergistic effect.

[0153] Example 5.

[0154] Patient information: A 52-year-old male with a history of hemorrhoids for more than 10 years, long-term bleeding during defecation, almost daily bleeding, occasionally accompanied by mild pain, and symptoms worsen after prolonged sitting.

[0155] Treatment Formula 1: Sophora fruit 10 parts by weight, black medlar 15 parts by weight, mint 5 parts by weight, purple cabbage 10 parts by weight, ginger 8 parts by weight, purple carrot 25 parts by weight, blueberry 40 parts by weight, cranberry 15 parts by weight, strawberry 10 parts by weight, orange 30 parts by weight, purple eggplant 10 parts by weight, spinach 14 parts by weight, broccoli 14 parts by weight, purple perilla 9 parts by weight, beetroot 8 parts by weight, red bell pepper 25 parts by weight, chard 10 parts by weight, white radish 5 parts by weight, and cabbage 30 parts by weight.

[0156] Formula form: Compound powder.

[0157] Effect: First day: bleeding during defecation was significantly reduced, and pain was slightly relieved. Second day: bleeding was basically stopped, and defecation was smooth. Continuous use for 10 days: once a day, no bleeding during the period, significant improvement in discomfort in the anal area, and symptoms no longer worsen after prolonged sitting.

[0158] Treatment Formula 2: Compared with Treatment Formula 1, it lacks sophora fruit, black medlar, mint and purple cabbage, and the rest of the formula components and parts are the same.

[0159] Specifically contains: ginger 8 parts by weight, purple carrot 25 parts by weight, blueberry 40 parts by weight, cranberry 15 parts by weight, strawberry 10 parts by weight, orange 30 parts by weight, purple eggplant 10 parts by weight, spinach 14 parts by weight, broccoli 14 parts by weight, purple perilla 9 parts by weight, beetroot 8 parts by weight, red bell pepper 25 parts by weight, chard 10 parts by weight, white radish 5 parts by weight, and cabbage 30 parts by weight.

[0160] Formula form: Compound powder.

[0161] Effect: Bleeding during defecation gradually decreased by the 5th day of use. Continued use to the 10th day, and the amount of blood was significantly reduced compared to before, but the pain did not significantly decrease.

[0162] Further, the condition of the patient after taking the composition for 10 days was scored according to the method of Example 1.3, and the results are shown in Table 4.

[0163] Table 4. Condition of the patient

[0164]

[0165] From the above results, it can be seen that the composition of the present application can effectively relieve the patient's hemorrhoids and improve the symptoms of venous insufficiency. Moreover, the effect is extremely fast, and there is a therapeutic effect after one day of use. The therapeutic formula 2 lacks sophora, black medlar, mint and purple cabbage, and the therapeutic effect is significantly slower and significantly worse (Table 4). This further illustrates that the components of the composition of the present application have a synergistic effect.

[0166] Example 6.

[0167] Patient information: a 34-year-old woman, 2 months after childbirth, recent hemorrhoids aggravated, obvious pain during defecation, swelling in the anal area, occasional prolapse of hemorrhoids, with a small amount of bleeding, symptoms aggravated after standing for a long time.

[0168] Therapeutic formula 1: sophora 10 parts by weight, black medlar 15 parts by weight, mint 5 parts by weight, purple cabbage 10 parts by weight, ginger 8 parts by weight, purple carrot 25 parts by weight, blueberry 40 parts by weight, cranberry 15 parts by weight, strawberry 10 parts by weight, orange 30 parts by weight, purple eggplant 10 parts by weight, spinach 28 parts by weight, broccoli 9 parts by weight, purple perilla 7 parts by weight, beetroot 10 parts by weight, red sweet pepper 17 parts by weight, gai lan 6 parts by weight, white radish 8 parts by weight, and cabbage 22 parts by weight.

[0169] Formula form: compound powder.

[0170] Effect: 3 days of taking: pain significantly reduced, discomfort during defecation decreased, and the degree of swelling of hemorrhoids slightly relieved. 7 days of taking: hemorrhoids swelling basically subsided, standing time extended, and discomfort significantly reduced. 10 days of taking: defecation smooth, pain basically disappeared, and returned to normal life, and no prolapse of hemorrhoids during taking.

[0171] Therapeutic formula 2: compared with therapeutic formula 1, it lacks purple carrot, cranberry, strawberry and orange, and the rest of the formula components and parts are the same.

[0172] Specifically contains: sophora 10 parts by weight, black medlar 15 parts by weight, mint 5 parts by weight, purple cabbage 10 parts by weight, ginger 8 parts by weight, blueberry 40 parts by weight, purple eggplant 10 parts by weight, spinach 28 parts by weight, broccoli 9 parts by weight, purple perilla 7 parts by weight, beetroot 10 parts by weight, red sweet pepper 17 parts by weight, gai lan 6 parts by weight, white radish 8 parts by weight, and cabbage 22 parts by weight.

[0173] Form: Compound powder.

[0174] Effect: After 3 days of taking, the pain was slightly reduced, and the swelling of the hemorrhoids was slightly relieved, but the hemorrhoids still occasionally prolapsed. After 10 days of taking, there was no obvious improvement compared to before.

[0175] Further, according to the method of Example 1.3, the condition of the patient after taking for 10 days was scored, and the specific effect is shown in Table 5.

[0176] Table 5. Patient condition

[0177]

[0178] From the above results, it can be seen that the composition of the present application can effectively relieve the patient's hemorrhoids and relieve anal pain and swelling. Moreover, it has a very fast effect, and has a therapeutic effect after three days of use. The therapeutic effect of Treatment Formula 2, which lacks purple carrot, cranberry, strawberry, and orange, is significantly worse (Table 5). This further illustrates that the components of the composition of the present application have a synergistic effect.

[0179] Example 7.

[0180] Patient information: A 36-year-old woman found anal swelling and prolapse during defecation, defecation pain, and sometimes blood on the toilet paper. Constipation was caused by irregular diet and lack of exercise, and emotional anxiety.

[0181] Treatment Formula 1: Sophora 10 parts by weight, black medlar 15 parts by weight, mint 5 parts by weight, purple cabbage 10 parts by weight, ginger 8 parts by weight, purple carrot 25 parts by weight, blueberry 40 parts by weight, cranberry 15 parts by weight, strawberry 10 parts by weight, orange 30 parts by weight, purple eggplant 10 parts by weight, spinach 25 parts by weight, broccoli 10 parts by weight, perilla 7 parts by weight, beetroot 6 parts by weight, red sweet pepper 20 parts by weight, gai lan 5 parts by weight, white radish 7 parts by weight, and cabbage 18 parts by weight.

[0182] Form: Compound powder.

[0183] Effect: After 3 days of taking, the defecation became smooth, the swelling was reduced, there was no obvious tearing pain, and the bleeding disappeared. After 10 days, the patient felt much more comfortable after defecation, and the mental state gradually returned to normal.

[0184] Treatment Formula 2: Compared with Treatment Formula 1, it lacks purple carrot, spinach, broccoli, and perilla, and the rest of the formula components and parts are the same.

[0185] Specifically comprising: sophora 10 parts by weight, black medlar 15 parts by weight, mint 5 parts by weight, purple cabbage 10 parts by weight, ginger 8 parts by weight, blueberry 40 parts by weight, cranberry 15 parts by weight, strawberry 10 parts by weight, orange 30 parts by weight, purple eggplant 10 parts by weight, beetroot 6 parts by weight, red sweet pepper 20 parts by weight, gai lan 5 parts by weight, white radish 7 parts by weight, Chinese cabbage 18 parts by weight

[0186] Form of the formula: compound powder.

[0187] Effect: After taking for 3 days, the degree of pain and constipation was reduced, but there were still occasional bleeding. After 10 days of continuous taking, the symptoms were further reduced, but not as good as treatment formula 1.

[0188] Further, according to the method of Example 1.3, the condition of the patient after taking for 10 days was scored, and the specific effect is shown in Table 6.

[0189] Table 6. Patient condition

[0190]

[0191] From the above results, it can be seen that the composition of the present application can effectively relieve the constipation of the patient and relieve the mental tension of the patient. Moreover, the effect is extremely fast, and there is a therapeutic effect after three days of use. The therapeutic effect of treatment formula 2 is obviously poorer (Table 6) due to the lack of purple carrot, spinach, broccoli and perilla in the treatment formula 2. This further illustrates that the components of the composition of the present application have a synergistic effect.

[0192] Example 8.

[0193] Patient information: a 46-year-old male, a bus driver, with recurrent hemorrhoids. Recently, due to hot weather and more spicy diet, he has anal distension, severe pain during defecation, and even affects normal work.

[0194] Treatment formula 1: sophora 12 parts by weight, black medlar 20 parts by weight, mint 6 parts by weight, purple cabbage 12 parts by weight, ginger 9 parts by weight, purple carrot 28 parts by weight, blueberry 38 parts by weight, cranberry 18 parts by weight, strawberry 12 parts by weight, orange 28 parts by weight, purple eggplant 12 parts by weight, spinach 22 parts by weight, broccoli 15 parts by weight, perilla 6 parts by weight, beetroot 7 parts by weight, red sweet pepper 18 parts by weight, gai lan 6 parts by weight, white radish 6 parts by weight, Chinese cabbage 20 parts by weight.

[0195] Form of the formula: compound powder.

[0196] Effect: After taking for 2 days, the defecation was slightly easier, and the discomfort during prolonged sitting was significantly relieved on the 3rd day. After 10 days of continuous taking, the pain was relieved, and even a few hours of continuous driving was no longer "uncomfortable".

[0197] Treatment Formula 2: Compared with Treatment Formula 1, beetroot, red bell pepper, chard, white radish and Chinese cabbage are absent, and the rest of the formula components and proportions are the same.

[0198] Specifically comprising: 12 parts by weight of sophora, 20 parts by weight of black medlar, 6 parts by weight of mint, 12 parts by weight of purple cabbage, 9 parts by weight of ginger, 28 parts by weight of purple carrot, 38 parts by weight of blueberry, 18 parts by weight of cranberry, 12 parts by weight of strawberry, 28 parts by weight of orange, 12 parts by weight of purple eggplant, 22 parts by weight of spinach, 15 parts by weight of broccoli, and 6 parts by weight of purple perilla.

[0199] Formula form: compound powder.

[0200] Effect: After 5 days of taking, the pain is reduced, and the defecation is easier than before, but there is still obvious discomfort after continuous driving.

[0201] Further, according to the method of Example 1.3, the condition of the patient after taking the above for 10 days is scored, and the specific effect is shown in Table 7.

[0202] Table 7. Patient condition

[0203] Pain Visual Analog Score (before use) Pain Visual Analog Score (after use) Treatment Formulation 1 9 3 Treatment Formulation 2 9 6

[0204] From the above results, it can be seen that the composition of the present application can effectively relieve the patient's hemorrhoids, relieve anal pain and swelling. Moreover, it takes effect very quickly, and has a therapeutic effect after two days of use. The therapeutic effect of Treatment Formula 2 is significantly worse, and it takes a longer time to play a therapeutic effect (Table 7). This further illustrates that the components of the composition of the present application have a synergistic effect.

[0205] Example 9.

[0206] Patient information: a 32-year-old woman with postpartum venous dysfunction, prone to lower extremity edema after standing for a long time, and obvious leg coldness at night.

[0207] Treatment formula: 10 parts by weight of sophora, 15 parts by weight of black medlar, 5 parts by weight of mint, 10 parts by weight of purple cabbage, 8 parts by weight of ginger, 25 parts by weight of purple carrot, 40 parts by weight of blueberry, 15 parts by weight of cranberry, 10 parts by weight of strawberry, 30 parts by weight of orange, 10 parts by weight of purple eggplant, 30 parts by weight of spinach, 8 parts by weight of broccoli, 5 parts by weight of purple perilla, 10 parts by weight of beetroot, 15 parts by weight of red bell pepper, 6 parts by weight of chard, 6 parts by weight of white radish, and 12 parts by weight of Chinese cabbage.

[0208] Formula form: compound powder.

[0209] Effect: After 10 days of continuous use, edema was reduced, leg coldness was reduced, standing time was extended, and overall blood circulation was improved. This shows that the formula of the present application can effectively alleviate lower extremity venous reflux disorder, reduce edema and promote blood circulation.

[0210] Example 10.

[0211] Patient information: A 50-year-old woman with long-term venous reflux disorder, prone to leg cramps at night, and obvious calf stiffness in the morning.

[0212] Treatment formula: 10 parts by weight of plumula, 15 parts by weight of black medlar, 5 parts by weight of mint, 10 parts by weight of purple cabbage, 8 parts by weight of ginger, 25 parts by weight of purple carrot, 40 parts by weight of blueberry, 15 parts by weight of cranberry, 10 parts by weight of strawberry, 30 parts by weight of orange, 10 parts by weight of purple eggplant, 10 parts by weight of spinach, 25 parts by weight of broccoli, 8 parts by weight of purple perilla, 6 parts by weight of beetroot, 18 parts by weight of red sweet pepper, 7 parts by weight of gai lan, 9 parts by weight of white radish, and 18 parts by weight of Chinese cabbage.

[0213] Formula form: Compound powder.

[0214] Effect: After 7 days of use, the number of night cramps was reduced, and the morning leg stiffness was relieved; after 20 days of continuous use, the leg flexibility was restored, and the blood circulation was improved. This shows that the formula of the present application can effectively alleviate lower extremity venous reflux disorder, reduce edema and promote blood circulation.

[0215] Example 11.

[0216] Patient information: A 41-year-old male with obvious lower extremity edema after long-term exercise, poor venous reflux, and occasional calf pain.

[0217] Treatment formula: 10 parts by weight of plumula, 15 parts by weight of black medlar, 5 parts by weight of mint, 10 parts by weight of purple cabbage, 8 parts by weight of ginger, 25 parts by weight of purple carrot, 40 parts by weight of blueberry, 15 parts by weight of cranberry, 10 parts by weight of strawberry, 30 parts by weight of orange, 10 parts by weight of purple eggplant, 18 parts by weight of spinach, 12 parts by weight of broccoli, 10 parts by weight of purple perilla, 7 parts by weight of beetroot, 12 parts by weight of red sweet pepper, 8 parts by weight of gai lan, 10 parts by weight of white radish, and 25 parts by weight of Chinese cabbage.

[0218] Formula form: Compound powder.

[0219] Effect: After 10 days of continuous use, the edema after exercise was significantly relieved, the calf pain was reduced, and the leg felt more relaxed. This shows that the formula of the present application can effectively alleviate lower extremity venous reflux disorder, reduce edema and promote blood circulation.

[0220] Example 12.

[0221] Patient information: 44-year-old female, long-term venous insufficiency, obvious edema in lower leg, symptoms aggravated in summer, skin occasionally itchy.

[0222] Treatment formula: 10 parts by weight of plum blossom, 15 parts by weight of black medlar, 5 parts by weight of mint, 10 parts by weight of purple cabbage, 8 parts by weight of ginger, 25 parts by weight of purple carrot, 40 parts by weight of blueberry, 15 parts by weight of cranberry, 10 parts by weight of strawberry, 30 parts by weight of orange, 10 parts by weight of purple eggplant, 22 parts by weight of spinach, 10 parts by weight of broccoli, 6 parts by weight of purple perilla, 9 parts by weight of beetroot, 14 parts by weight of red sweet pepper, 5 parts by weight of gai lan, 7 parts by weight of white radish, 10 parts by weight of Chinese cabbage.

[0223] Formula form: compound powder.

[0224] Effect: After continuous taking for 5 days, edema is relieved; after continuous taking for 15 days, skin itching is reduced, and venous reflux is improved. It shows that the formula of the application can effectively relieve lower limb venous reflux disorder, reduce edema and relieve skin itching.

[0225] Example 13.

[0226] Patient information: 58-year-old male, venous insufficiency combined with lower leg phlebitis, skin redness, local fever, symptoms aggravated after standing for a long time.

[0227] Treatment formula: 10 parts by weight of plum blossom, 15 parts by weight of black medlar, 5 parts by weight of mint, 10 parts by weight of purple cabbage, 8 parts by weight of ginger, 25 parts by weight of purple carrot, 40 parts by weight of blueberry, 15 parts by weight of cranberry, 10 parts by weight of strawberry, 30 parts by weight of orange, 10 parts by weight of purple eggplant, 12 parts by weight of spinach, 18 parts by weight of broccoli, 5 parts by weight of purple perilla, 5 parts by weight of beetroot, 20 parts by weight of red sweet pepper, 9 parts by weight of gai lan, 6 parts by weight of white radish, 15 parts by weight of Chinese cabbage.

[0228] Formula form: compound powder.

[0229] Effect: After taking for 7 days, skin inflammation is reduced, and local fever is decreased; after continuous taking for 20 days, phlebitis symptoms are obviously improved. It shows that the formula of the application can effectively relieve lower limb venous reflux disorder and improve skin itching and burning sensation caused by venous insufficiency.

[0230] Example 14.

[0231] Patient information: 32-year-old female, severe constipation during lactation, severe pain during defecation, and lump protruding around anus.

[0232] Treatment formula: Sophora 10 parts by weight, black wolfberry 15 parts by weight, mint 5 parts by weight, purple cabbage 10 parts by weight, ginger 8 parts by weight, purple carrot 25 parts by weight, blueberry 40 parts by weight, cranberry 15 parts by weight, strawberry 10 parts by weight, orange 30 parts by weight, purple eggplant 10 parts by weight, spinach 30 parts by weight, broccoli 8 parts by weight, purple perilla 5 parts by weight, beetroot 8 parts by weight, red sweet pepper 16 parts by weight, chard 6 parts by weight, white radish 8 parts by weight, cabbage 20 parts by weight.

[0233] Formula form: Compound powder.

[0234] Effect: After using the application for treatment for 7 days, the most obvious change is that defecation is no longer so painful, and the swelling is gradually reduced. The whole person is much lighter, and the mood is stable. Finally, you can take your child out safely. It shows that the formula of the application can effectively relieve constipation and improve the symptoms of anal swelling and pain.

[0235] Example 15.

[0236] Patient information: A 45-year-old male engaged in retail work, who needs to stand for a long time. Recently, hemorrhoids have recurred, and there is always residual stool after defecation, which affects work efficiency due to anal swelling and heat.

[0237] Treatment formula: Sophora 15 parts by weight, black wolfberry 18 parts by weight, mint 7 parts by weight, purple cabbage 14 parts by weight, ginger 10 parts by weight, purple carrot 30 parts by weight, blueberry 42 parts by weight, cranberry 20 parts by weight, strawberry 14 parts by weight, orange 35 parts by weight, purple eggplant 13 parts by weight, spinach 24 parts by weight, broccoli 10 parts by weight, purple perilla 6 parts by weight, beetroot 5 parts by weight, red sweet pepper 22 parts by weight, chard 5 parts by weight, white radish 7 parts by weight, cabbage 25 parts by weight.

[0238] Formula form: Compound powder.

[0239] Effect: After using the application for treatment for 14 days, the original two or three times a day to the toilet cannot be solved, now once can successfully finish. Standing for a long time does not feel bloated and painful, and the concentration during work is obviously improved. It shows that the formula of the application can effectively relieve hemorrhoids and improve the symptoms of anal swelling, pain, and swelling and heat.

[0240] Example 16.

[0241] Patient information: A 42-year-old male with lymphoma relapsed during chemotherapy, with uncontrolled bleeding, even affecting the progress of chemotherapy. The specialist doctor suggested surgery as soon as possible after the end of chemotherapy.

[0242] Treatment formula: 10 parts by weight of sophora, 15 parts by weight of black medlar, 5 parts by weight of mint, 10 parts by weight of purple cabbage, 8 parts by weight of ginger, 25 parts by weight of purple carrot, 40 parts by weight of blueberry, 15 parts by weight of cranberry, 10 parts by weight of strawberry, 30 parts by weight of orange, 10 parts by weight of purple eggplant, 26 parts by weight of spinach, 10 parts by weight of broccoli, 7 parts by weight of purple perilla, 9 parts by weight of beetroot, 15 parts by weight of red sweet pepper, 7 parts by weight of chard, 6 parts by weight of white radish, 18 parts by weight of Chinese cabbage.

[0243] Formula form: compound powder.

[0244] Effect: After 15 days of treatment, the bleeding gradually stopped after 3 days of taking, and there was no impact on the chemotherapy course. It shows that the formula of the application can effectively relieve hemorrhoids and improve the symptoms of anal bleeding.

[0245] As shown by the above experimental content, the compound powder and compound juice can improve venous insufficiency, achieving good effect of relieving varicose veins, capillary fragility and poor venous return, and at the same time, it can completely serve as daily nutritional supplement and improve immunity. The active ingredients can enhance the toughness of capillary, reduce vascular leakage, relieve edema, pain and heaviness caused by venous congestion, achieve the effect of improving hemorrhoids and venous insufficiency, especially chronic venous insufficiency (CVI); at the same time, the product is pure natural, no additives, no toxic side effects, easy to use, fast-acting, and has potential effects of promoting blood circulation, reducing thrombosis, protecting vascular health, etc.

[0246] Example 17.

[0247] Further, the application also verifies the effectiveness of the following formula composition in improving venous function.

[0248] Composition 1: (1) Mix 20 parts by weight of sophora, 18 parts by weight of black medlar, 5 parts by weight of mint, 12 parts by weight of purple cabbage, 10 parts by weight of ginger, 30 parts by weight of purple carrot, 45 parts by weight of blueberry, 25 parts by weight of cranberry, 15 parts by weight of strawberry, 20 parts by weight of lemon, 10 parts by weight of purple eggplant, 20 parts by weight of spinach, 12 parts by weight of broccoli, 6 parts by weight of purple perilla, 5 parts by weight of beetroot, 20 parts by weight of red sweet pepper, 6 parts by weight of chard, 5 parts by weight of white radish, 25 parts by weight of Chinese cabbage. (2) Wash the raw materials clean and cut into 1-2 cm blocks; dry the cut blocks through a vacuum freeze-drying equipment, with a vacuum degree of 10-50 Pa and a temperature not exceeding 60℃; grind the dried blocks into fine powder through a low-temperature grinding equipment; mix to obtain compound powder (packaging is solid beverage).

[0249] Composition 2: (1) Mix sophora 25 parts by weight, black medlar 22 parts by weight, mint 7 parts by weight, purple cabbage 18 parts by weight, ginger 12 parts by weight, purple carrot 35 parts by weight, blueberry 50 parts by weight, cranberry 30 parts by weight, strawberry 10 parts by weight, lemon 25 parts by weight, purple eggplant 15 parts by weight, spinach 15 parts by weight, broccoli 10 parts by weight, perilla 5 parts by weight, beetroot 7 parts by weight, red bell pepper 25 parts by weight, artichoke 7 parts by weight, white radish 8 parts by weight, Chinese cabbage 20 parts by weight.(2) Clean and cut the raw materials, and squeeze the raw materials through a juicing device to prepare a ready-to-drink juice or a juice mixed with water.

[0250] Composition 3: (1) Mix sophora 15 parts by weight, black medlar 12 parts by weight, mint 6 parts by weight, purple cabbage 20 parts by weight, ginger 8 parts by weight, purple carrot 40 parts by weight, blueberry 60 parts by weight, cranberry 10 parts by weight, strawberry 20 parts by weight, lemon 30 parts by weight, purple eggplant 8 parts by weight, spinach 25 parts by weight, broccoli 20 parts by weight, perilla 7 parts by weight, beetroot 10 parts by weight, red bell pepper 15 parts by weight, artichoke 9 parts by weight, white radish 6 parts by weight, Chinese cabbage 18 parts by weight.(2) Clean and cut the raw materials, and squeeze the raw materials through a juicing device to prepare a juice, and mix the juice with water by weight to prepare a juice.

[0251] Composition 4: (1) Mix sophora 10 parts by weight, black medlar 25 parts by weight, mint 4 parts by weight, purple cabbage 25 parts by weight, ginger 13 parts by weight, purple carrot 20 parts by weight, blueberry 35 parts by weight, cranberry 28 parts by weight, strawberry 12 parts by weight, lemon 18 parts by weight, purple eggplant 17 parts by weight, spinach 10 parts by weight, broccoli 25 parts by weight, perilla 8 parts by weight, beetroot 8 parts by weight, red bell pepper 30 parts by weight, artichoke 5 parts by weight, white radish 9 parts by weight, Chinese cabbage 12 parts by weight.(2) Clean the materials, cut the cleaned materials into 1 cm blocks, and dry the cut blocks in a vacuum freeze-drying device, and grind the dried blocks into a powder state using a low-temperature grinding machine with a fineness of 80 mesh to obtain a pure natural compound.

[0252] Composition 5: (1) Mix sophora 30 parts by weight, black medlar 20 parts by weight, mint 10 parts by weight, purple cabbage 10 parts by weight, ginger 5 parts by weight, purple carrot 15 parts by weight, blueberry 55 parts by weight, cranberry 12 parts by weight, strawberry 25 parts by weight, lemon 15 parts by weight, purple eggplant 5 parts by weight, spinach 30 parts by weight, broccoli 30 parts by weight, perilla 9 parts by weight, beetroot 6 parts by weight, red bell pepper 10 parts by weight, artichoke 10 parts by weight, white radish 5 parts by weight, Chinese cabbage 10 parts by weight.(2) Clean and cut the raw materials, and squeeze the raw materials through a juicing device to prepare a juice, and mix the juice with water to prepare a juice.

[0253] Composition 6: (1) 22 parts by weight of sophora, 14 parts by weight of black medlar, 12 parts by weight of mint, 30 parts by weight of purple cabbage, 14 parts by weight of ginger, 10 parts by weight of purple carrot, 40 parts by weight of blueberry, 18 parts by weight of cranberry, 8 parts by weight of strawberry, 35 parts by weight of lemon, 18 parts by weight of purple eggplant, 18 parts by weight of spinach, 15 parts by weight of broccoli, 5 parts by weight of purple perilla, 9 parts by weight of beetroot, 18 parts by weight of red bell pepper, 8 parts by weight of chard, 7 parts by weight of white carrot, 15 parts by weight of Chinese cabbage are mixed. (2) The materials are washed, the washed materials are cut into 2 cm pieces, the pieces are put into a vacuum freeze-drying apparatus to dry the cut pieces, and the dried pieces are ground into powder by a low-temperature grinder with fineness of 100 mesh to obtain a pure natural compound.

[0254] Composition 7: (1) 12 parts by weight of sophora, 16 parts by weight of black medlar, 3 parts by weight of mint, 8 parts by weight of purple cabbage, 11 parts by weight of ginger, 38 parts by weight of purple carrot, 58 parts by weight of blueberry, 14 parts by weight of cranberry, 18 parts by weight of strawberry, 50 parts by weight of lemon, 6 parts by weight of purple eggplant, 28 parts by weight of spinach, 7 parts by weight of broccoli, 6 parts by weight of purple perilla, 7 parts by weight of beetroot, 22 parts by weight of red bell pepper, 5 parts by weight of chard, 6 parts by weight of white carrot, and 17 parts by weight of Chinese cabbage are mixed. (2) The materials are washed, the washed materials are cut into 2 cm pieces, the pieces are put into a vacuum freeze-drying apparatus to dry the cut pieces, and the dried pieces are ground into powder by a low-temperature grinder with fineness of 120 mesh to obtain a pure natural compound.

[0255] Composition 8: (1) 17 parts by weight of sophora, 19 parts by weight of black medlar, 6 parts by weight of mint, 22 parts by weight of purple cabbage, 6 parts by weight of ginger, 25 parts by weight of purple carrot, 30 parts by weight of blueberry, 22 parts by weight of cranberry, 22 parts by weight of strawberry, 40 parts by weight of lemon, 14 parts by weight of purple eggplant, 26 parts by weight of spinach, 6 parts by weight of broccoli, 10 parts by weight of purple perilla, 5 parts by weight of beetroot, 12 parts by weight of red bell pepper, 7 parts by weight of chard, 10 parts by weight of white carrot, and 22 parts by weight of Chinese cabbage are mixed. (2) The raw materials are washed and cut, and the raw materials are squeezed by a juicing apparatus to prepare a ready-to-drink juice.

[0256] Composition 9: (1) 19 parts by weight of sophora, 13 parts by weight of black wolfberry, 15 parts by weight of mint, 27 parts by weight of purple cabbage, 7 parts by weight of ginger, 32 parts by weight of purple carrot, 48 parts by weight of blueberry, 16 parts by weight of cranberry, 7 parts by weight of strawberry, 60 parts by weight of lemon, 20 parts by weight of purple eggplant, 5 parts by weight of spinach, 18 parts by weight of broccoli, 8 parts by weight of purple perilla, 10 parts by weight of beetroot, 28 parts by weight of red bell pepper, 10 parts by weight of gai lan, 9 parts by weight of white carrot, 30 parts by weight of Chinese cabbage are mixed. (2) The materials are washed, the washed materials are cut into 2 cm pieces, the pieces are put into a vacuum freeze-drying apparatus to dry the cut pieces, and the dried pieces are ground into powder by a low-temperature grinder with fineness of 80 mesh to obtain a pure natural compound.

[0257] Composition 10: (1) 28 parts by weight of sophora, 23 parts by weight of black wolfberry, 9 parts by weight of mint, 18 parts by weight of purple cabbage, 9 parts by weight of ginger, 36 parts by weight of purple carrot, 25 parts by weight of blueberry, 26 parts by weight of cranberry, 13 parts by weight of strawberry, 12 parts by weight of lemon, 11 parts by weight of purple eggplant, 22 parts by weight of spinach, 14 parts by weight of broccoli, 7 parts by weight of purple perilla, 8 parts by weight of beetroot, 17 parts by weight of red bell pepper, 6 parts by weight of gai lan, 8 parts by weight of white carrot, 11 parts by weight of Chinese cabbage are mixed. (2) The materials are washed, the washed materials are cut into 2 cm pieces, the pieces are put into a vacuum freeze-drying apparatus to dry the cut pieces, and the dried pieces are ground into powder by a low-temperature grinder with fineness of 100 mesh to obtain a pure natural compound.

[0258] Although the specific embodiments of the present application have been described in detail, those skilled in the art will understand that various modifications and changes can be made to the details without departing from the spirit and scope of the present application according to all the teachings disclosed herein. The entire contents of the present application are given by the appended claims and any equivalents thereof.

Claims

1. A composition comprising the following components: black currant, mint, purple cabbage, ginger, purple carrot, cranberry, strawberry, purple eggplant, spinach, broccoli, purple shiso, beetroot, red bell pepper, artichoke, white carrot, Chinese cabbage, component B, and component C; wherein component B is selected from the group consisting of blueberry, elderberry, mayhaw, lingonberry, or any combination thereof; component C is selected from the group consisting of orange, tangerine, lemon, bergamot, or any combination thereof.

2. The composition of claim 1, comprising the following components: black currant, mint, purple cabbage, ginger, purple carrot, cranberry, strawberry, purple eggplant, spinach, broccoli, purple shiso, beetroot, red bell pepper, artichoke, white carrot, Chinese cabbage, component A, component B, and component C; wherein component A is selected from the group consisting of flos sophorae, sophora flower, or any combination thereof; component B is selected from the group consisting of blueberry, elderberry, mayhaw, lingonberry, or any combination thereof; component C is selected from the group consisting of orange, tangerine, lemon, bergamot, or any combination thereof.

3. The composition of claim 1, having one or more features selected from the group consisting of: (1) the composition comprises the following components: black currant, mint, purple cabbage, ginger, purple carrot, cranberry, strawberry, purple eggplant, spinach, broccoli, purple shiso, beetroot, red bell pepper, artichoke, white carrot, Chinese cabbage, blueberry, and orange; (2) the composition comprises the following components: black currant, mint, purple cabbage, ginger, purple carrot, cranberry, strawberry, purple eggplant, spinach, broccoli, purple shiso, beetroot, red bell pepper, artichoke, white carrot, Chinese cabbage, blueberry, and lemon.

4. The composition of claim 2, having one or more features selected from the group consisting of: (1) the composition comprises the following components: black currant, mint, purple cabbage, ginger, purple carrot, cranberry, strawberry, purple eggplant, spinach, broccoli, purple shiso, beetroot, red bell pepper, artichoke, white carrot, Chinese cabbage, flos sophorae, blueberry, and orange; (2) the composition comprises the following components: black currant, mint, purple cabbage, ginger, purple carrot, cranberry, strawberry, purple eggplant, spinach, broccoli, purple shiso, beetroot, red bell pepper, artichoke, white carrot, Chinese cabbage, sophora flower, blueberry, and orange; (3) the composition comprises the following components: black currant, mint, purple cabbage, ginger, purple carrot, cranberry, strawberry, purple eggplant, spinach, broccoli, purple shiso, beetroot, red bell pepper, artichoke, white carrot, Chinese cabbage, flos sophorae, blueberry, and lemon; (4) the composition comprises the following components: black currant, mint, purple cabbage, ginger, purple carrot, cranberry, strawberry, purple eggplant, spinach, broccoli, purple shiso, beetroot, red bell pepper, artichoke, white carrot, Chinese cabbage, sophora flower, blueberry, and lemon.

5. The composition according to claim 1, comprising the following components in parts by weight: Lycium ruthenicum 5-25 parts, Mentha 3-15 parts, Purple Cabbage 5-30 parts, Ginger 5-15 parts, Purple Carrot 5-40 parts, Cranberry 10-30 parts, Strawberry 5-25 parts, Purple Eggplant 5-20 parts, Spinach 5-30 parts, Broccoli 5-30 parts, Purple Perilla 5-10 parts, Beetroot 5-10 parts, Red Bell Pepper 5-30 parts, Gai Lan 5-10 parts, White Radish 5-10 parts, Chinese Cabbage 5-30 parts, Component A 5-30 parts, Component B 10-60 parts, Component C 10-60 parts; wherein, component B is selected from the group consisting of blueberry, elderberry, mayhaw, lingonberry, or any combination thereof; component C is selected from the group consisting of orange, tangerine, lemon, bergamot, or any combination thereof. Preferably, the composition comprises the following components by weight parts: Lycium ruthenicum 15-20 parts, Mentha 5-10 parts, Purple cabbage 10-15 parts, Ginger 5-10 parts, Purple carrot 25-30 parts, Cranberry 15-20 parts, Strawberry 10-15 parts, Purple eggplant 10-15 parts, Spinach 10-30 parts, Broccoli 5-25 parts, Purple perilla 5-10 parts, Beetroot 5-10 parts, Red bell pepper 10-25 parts, Gai lan 5-10 parts, White carrot 5-10 parts, Chinese cabbage 5-30 parts, Component A 10-15 parts, Component B 35-45 parts, Component C 25-35 parts; wherein Component B is selected from blueberry, blue honeysuckle, Meiyu, bilberry, or any combination thereof; Component C is selected from orange, citrus, lemon, bergamot, or any combination thereof.

6. The composition according to claim 2, comprising the following components in parts by weight: Lycium ruthenicum 5-25 parts, Mentha 3-15 parts, Purple Cabbage 5-30 parts, Ginger 5-15 parts, Purple Carrot 5-40 parts, Cranberry 10-30 parts, Strawberry 5-25 parts, Purple Eggplant 5-20 parts, Spinach 5-30 parts, Broccoli 5-30 parts, Purple Perilla 5-10 parts, Beetroot 5-10 parts, Red Bell Pepper 5-30 parts, Gai Lan 5-10 parts, White Radish 5-10 parts, Chinese Cabbage 5-30 parts, Component A 5-30 parts, Component B 10-60 parts, Component C 10-60 parts; wherein, Component A is selected from sophora flower, sophora flower, or any combination thereof; Component B is selected from blueberry, blue honeysuckle, Meiyu, bilberry, or any combination thereof; Component C is selected from orange, citrus, lemon, bergamot, or any combination thereof; Preferably, the composition comprises the following components by weight parts: Lycium ruthenicum 15-20 parts, Mentha 5-10 parts, Purple cabbage 10-15 parts, Ginger 5-10 parts, Purple carrot 25-30 parts, Cranberry 15-20 parts, Strawberry 10-15 parts, Purple eggplant 10-15 parts, Spinach 10-30 parts, Broccoli 5-25 parts, Purple perilla 5-10 parts, Beetroot 5-10 parts, Red bell pepper 10-25 parts, Gai lan 5-10 parts, White carrot 5-10 parts, Chinese cabbage 5-30 parts, Component A 10-15 parts, Component B 35-45 parts, Component C 25-35 parts; wherein Component A is selected from sophora flower, sophora flower, or any combination thereof; Component B is selected from blueberry, blue honeysuckle, Meiyu, bilberry, or any combination thereof; Component C is selected from orange, citrus, lemon, bergamot, or any combination thereof.

7. The composition of claim 1, comprising the following components by weight parts: Lycium ruthenicum 5-25 parts, Mentha 3-15 parts, Purple cabbage 5-30 parts, Ginger 5-15 parts, Purple carrot 5-40 parts, Cranberry 10-30 parts, Strawberry 5-25 parts, Purple eggplant 5-20 parts, Spinach 5-30 parts, Broccoli 5-30 parts, Purple perilla 5-10 parts, Beetroot 5-10 parts, Red bell pepper 5-30 parts, Gai lan 5-10 parts, White carrot 5-10 parts, Chinese cabbage 5-30 parts, Blueberry 10-60 parts, Orange 10-60 parts; Preferably, the composition comprises the following components by weight parts: Lycium ruthenicum 15-20 parts, Mentha 5-10 parts, Purple cabbage 10-15 parts, Ginger 5-10 parts, Purple carrot 25-30 parts, Cranberry 15-20 parts, Strawberry 10-15 parts, Purple eggplant 10-15 parts, Spinach 10-30 parts, Broccoli 5-25 parts, Purple perilla 5-10 parts, Beetroot 5-10 parts, Red bell pepper 10-25 parts, Gai lan 5-10 parts, White carrot 5-10 parts, Chinese cabbage 5-30 parts, Blueberry 35-45 parts, Orange 25-35 parts.

8. The composition of claim 2, comprising the following components in parts by weight: Lycium ruthenicum 5-25 parts, Mentha 3-15 parts, Purple Cabbage 5-30 parts, Ginger 5-15 parts, Purple Carrot 5-40 parts, Cranberry 10-30 parts, Strawberry 5-25 parts, Purple Eggplant 5-20 parts, Spinach 5-30 parts, Broccoli 5-30 parts, Perilla 5-10 parts, Beetroot 5-10 parts, Red Bell Pepper 5-30 parts, Lettuce 5-10 parts, White Radish 5-10 parts, Chinese Cabbage 5-30 parts, Sophora Flower 5-30 parts, Blueberry 10-60 parts, Orange 10-60 parts; Preferably, the composition comprises the following components in parts by weight: Lycium ruthenicum 15-20 parts, Mentha 5-10 parts, Purple Cabbage 10-15 parts, Ginger 5-10 parts, Purple Carrot 25-30 parts, Cranberry 15-20 parts, Strawberry 10-15 parts, Purple Eggplant 10-15 parts, Spinach 10-30 parts, Broccoli 5-25 parts, Perilla 5-10 parts, Beetroot 5-10 parts, Red Bell Pepper 10-25 parts, Lettuce 5-10 parts, White Radish 5-10 parts, Chinese Cabbage 5-30 parts, Sophora Flower 10-15 parts, Blueberry 35-45 parts, Orange 25-35 parts.

9. A pharmaceutical composition comprising the composition of any one of claims 1-8; Preferably, the pharmaceutical composition further comprises an additional active ingredient; Preferably, the additional active ingredient is capable of treating and / or ameliorating a disease and / or a symptom associated with venous insufficiency (e.g., heavy lower limbs, swelling of lower limbs, skin pigmentation, skin burning, skin itching, hemorrhoids, muscle cramps, muscle spasms, varicose veins, venous ulcers) in a subject; Preferably, the additional active ingredient is selected from the group consisting of flavonoids, polyphenols, saponins, terpenoids (e.g., triterpenoids), alkaloids (e.g., solasodine), organosulfides (e.g., thioglucosides), coumarins (e.g., coumarin), polysaccharides (e.g., lycium polysaccharides), phenolic acids, metal ions, vitamins, coenzymes, or any combination thereof; Preferably, the additional active ingredient is selected from the group consisting of troxerutin, rutin, diosmin, quercetin, hesperidin, β-escin, menthol, asiaticoside, berberine, magnesium ion, vitamin C, coenzyme Q10, or any combination thereof; Preferably, the pharmaceutical composition further comprises a pharmaceutically acceptable carrier and / or excipient; Preferably, the pharmaceutical composition is in the form of a solution, a suspension, a powder, a tablet, a pill, an emulsion, a gel, a capsule, a granule, an elixir, a lozenge, a suppository, an injection, an inhalant, or a spray.

10. A dietary supplement comprising the composition of any one of claims 1-8. Preferably, the dietary supplement further comprises additional excipients; Preferably, the additional excipients are selected from food additives, food processing aids, nutritional fortifiers; Preferably, the food additives are selected from sweeteners, acidity regulators, food spices; Preferably, the additional excipients are selected from honey, xylitol, erythritol, citric acid, DL-malic acid, pectin, maltodextrin, resistant dextrin, vitamin C, vitamin E, calcium, iron, zinc, or any combination thereof; Preferably, the dietary supplement is selected from baked goods, pressed goods, puffed goods, baked goods; Preferably, the dietary supplement is selected from solid beverages, lyophilized blocks, candies, or liquid beverages (e.g., ready-to-drink juices, concentrated juices).

11. A method for preparing the pharmaceutical composition of claim 9 or the dietary supplement of claim 10, comprising: (1) providing the composition of any one of claims 1-8; preferably, the components in the composition are in the form of cut pieces or granules; (2) freeze-drying the composition; Preferably, the method further comprises: further processing the product obtained in (2) into a powder product.

12. A method for preparing the pharmaceutical composition of claim 9 or the dietary supplement of claim 10, comprising: (1) providing the composition of any one of claims 1-8; preferably, the components in the composition are in the form of a slurry or homogenate; (2) freeze-drying the composition; Preferably, the method further comprises: further processing the product obtained in (2) into a block product; Preferably, the method further comprises: reconstituting the obtained block product into a liquid; Preferably, the method further comprises: forming a flavored coating (e.g., chocolate, honey, natural spices, or any combination thereof) on the outer surface of the obtained block product.

13. A method for preparing the pharmaceutical composition of claim 9 or the dietary supplement of claim 10, comprising: (1) providing the composition of any one of claims 1-8; (2) subjecting the composition to juicing.

14. Use of the composition of any one of claims 1-8 or the pharmaceutical composition of claim 9 or the dietary supplement of claim 10 in the preparation of a medicament for treating and / or ameliorating a disease and / or a symptom associated with venous insufficiency in a subject; Preferably, the disease and / or symptom is selected from: heaviness in the lower extremities, swelling in the lower extremities, skin pigmentation, skin burning, skin itching, hemorrhoids, muscle cramps, muscle spasms, varicose veins, venous ulcers, or any combination thereof; Preferably, the subject is a mammal; Preferably, the mammal is selected from a mouse, a pig, a rabbit, a monkey, a sheep, a human.

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