Image differentiated multiplex assays

By employing analog code encoding on microcarriers, the resolution limitation problem in existing technologies has been solved, enabling efficient and low-cost multiple determinations and improving identification accuracy and sample utilization.

CN121109115APending Publication Date: 2025-12-12PLEXBIO
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Patent Information

Application Number
CN202511097675.7
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Priority Date
2015-06-11
Filing Date
2016-06-10
Publication Date
2025-12-12

AI Technical Summary

Technical Problem

Existing multiplex measurement systems are limited in resolution, and the number of unique identifiers for digital barcodes and fluorescent codes is limited and prone to recognition errors, failing to meet the requirements for high throughput and high resolution.

Method used

The microcarriers, which employ analog code encoding, are formed by depositing an opaque polymer layer on a substantially transparent polymer layer and etching it into a two-dimensional shape. Combined with a magnetic layer and a trapping agent, the microcarriers enable encoding and analyte trapping.

Benefits of technology

It achieves an almost unlimited number of unique identifiers, reduces identification errors, improves the resolution and efficiency of multiplex assays, and reduces sample volume and reagent costs.

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Abstract

The invention relates to image differentiated multiplex assays. Provided herein are encoded microcarriers for analyte detection in multiplex assays. The microcarrier is encoded using an analog code for identification and includes a capture agent for analyte detection. Also provided are methods of making the encoded microcarriers disclosed herein. Further provided are methods and kits related to multiplex assays using the microcarriers described herein.
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