Skin care composition with soothing, repairing and antioxidant functions

Abstract

The invention belongs to the field of daily chemicals, and particularly relates to a skin care composition with soothing, repairing and antioxidant functions, which is prepared from the following components in percentage by weight: 0.38 to 1.5 percent of soothing and anti-inflammatory compound, 2.2 to 4.8 percent of barrier repairing compound, 0.35 to 1.45 percent of antioxidant compound, 1.0 to 9.8 percent of humectant, 1.5 to 5 percent of emulsifier, 0.2 to 0.7 percent of thickener, 1 to 6 percent of silicone oil conditioner, 0.9 to 1.8 percent of preservative, 0.03 to 0.08 percent of chelating agent, 0.05 to 0.2 percent of pH regulator and the balance of water. The traditional Chinese medicine composition has the functions of relieving inflammation, repairing skin barrier and resisting oxidation, and has an excellent maintenance effect on people with sensitive skin and premature skin.

Description

Technical Field

[0001] This invention belongs to the field of daily chemical products, and specifically relates to a skin care composition with soothing, repairing and antioxidant functions. Background Technology

[0002] With increasing environmental pressure and worsening air pollution, skin problems among people with sensitive skin and early signs of aging are becoming increasingly complex. This means that symptoms such as sensitivity and dryness caused by impaired skin barrier function, as well as skin aging and dullness caused by oxidative stress, coexist and have an adverse effect on human skin health.

[0003] To better care for sensitive and early-aging skin, people often choose to use skincare products in their daily lives. However, ordinary skincare products have some obvious shortcomings. For example, they are often single-function, focusing on replenishing lipids and repairing the physical barrier, but lacking antioxidant capacity and unable to combat free radical damage to the skin. On the other hand, the addition of antioxidants, such as high concentrations of vitamin C derivatives, to enhance the antioxidant capacity of skincare products can be highly irritating and unsuitable for fragile, sensitive skin. Furthermore, some skincare products have unbalanced ingredient combinations; for instance, the poor compatibility between lipid-soluble repair ingredients and water-soluble antioxidants leads to an unstable system and unsatisfactory skincare effects. In pursuit of better repair effects, skincare products often use large amounts of occlusive oils, resulting in a greasy, heavy feel and an unpleasant user experience. Preservatives and fragrances commonly used in skincare products also pose a potential sensitizing risk to sensitive skin.

[0004] Therefore, there is an urgent need for a skincare composition that can provide effective soothing, repairing, and antioxidant effects for people with sensitive and early signs of aging skin, in order to improve the skin health of these individuals. Summary of the Invention

[0005] The technical problem to be solved by the present invention is to provide a skin care composition with soothing, repairing and antioxidant functions. The composition of the present invention has the functions of soothing and anti-inflammatory, repairing the skin barrier and anti-oxidation, and has excellent care effect on sensitive skin and early aging skin.

[0006] The technical solution adopted by the present invention to solve the above problems is as follows: A skincare composition with soothing, repairing, and antioxidant functions comprises the following components by weight percentage: 0.38–1.5% soothing and anti-inflammatory complex, 2.2–4.8% barrier repair complex, 0.35–1.45% antioxidant complex, 1.0–9.8% moisturizer, 1.5–5% emulsifier, 0.2–0.7% thickener, 1–6% silicone oil conditioning agent, 0.9–1.8% preservative, 0.03–0.08% chelating agent, 0.05–0.2% pH adjuster, and the balance being water; The soothing and anti-inflammatory complex includes bisabolol, peony root extract, and ferulic acid; the barrier repair complex includes squalane, ceramide NP, and phytosphingosine; and the antioxidant complex includes astaxanthin and ferulic acid.

[0007] By employing the aforementioned technical solution, a scientifically formulated combination of specific soothing and anti-inflammatory complexes (bisabolol, peony root extract, ferulic acid), barrier repair complexes (ceramide NP, phytosphingosine), and antioxidant complexes (astaxanthin, ferulic acid) enhances the composition's immediate soothing, long-lasting repair, and three-dimensional antioxidant capabilities. Bisabolol inhibits lipoxygenase, peony root extract downregulates inflammatory factors such as TNF-α and IL-1α, and ferulic acid inhibits the NF-κB pathway, collectively achieving multi-target blockade of the inflammatory cascade, thereby achieving immediate soothing and anti-inflammatory effects. Ceramide NP directly replenishes lipids, and phytosphingosine acts as a precursor to promote endogenous synthesis, jointly reducing transepidermal water loss and increasing the stratum corneum's water content.

[0008] Further, the mass ratio of bisabolol, peony root extract, and ferulic acid is (0.5-2):(0.1-1):(1-10); the mass ratio of squalane, ceramide NP, and phytosphingosine is (5-20):(0.5-5):(0.5-3); and the mass ratio of astaxanthin and ferulic acid is (0.5-2):(5-20).

[0009] Further, the moisturizer includes at least one selected from glyceryl polyether-26, 1,3-butanediol, D-panthenol, and sodium hyaluronate crosspolymer; the sodium hyaluronate crosspolymer has a molecular weight of 1.0*10⁻⁶. 6 ~2.5*10 6 Da.

[0010] Further, the emulsifier includes at least one of polyglycerol-10 stearate, polysorbate-80, hydrogenated lecithin, PEG-100 stearate, cetearyl alcohol polyether-20, dehydrated sorbitan oleate, and sorbitan oleate.

[0011] Furthermore, the thickener includes at least one of carbomer, carboxymethyl deacetylated chitosan, xanthan gum, sodium acrylate / sodium acryloyl dimethyl taurate copolymer, and hydroxyethyl cellulose.

[0012] Furthermore, the silicone oil conditioning agent includes at least one of polydimethylsiloxane, cetearyl polymethylsiloxane, cyclopentadimethylsiloxane, phenyl polytrimethylsiloxane, and cetearyl polydimethylsiloxane.

[0013] Furthermore, the preservative includes at least one selected from p-hydroxyacetophenone, phenoxyethanol, capryloyl hydroxamic acid, 1,2-hexanediol, 1,2-pentanediol, and ethylhexylglycerin.

[0014] Furthermore, the chelating agent includes disodium EDTA.

[0015] Furthermore, the pH adjuster includes arginine.

[0016] The present invention has the following beneficial effects: 1. The composition of this invention possesses soothing and anti-inflammatory functions, repairs the skin barrier, and has antioxidant properties, while also exhibiting excellent skincare effects for sensitive skin and those experiencing early signs of aging. Through the synergistic effect of bisabolol, peony root extract, and ferulic acid, a triple anti-inflammatory pathway is formed, significantly inhibiting the expression of the inflammatory factor IL-6. Bisabolol inhibits lipoxygenase, while paeoniflorin in peony root extract downregulates the expression of upstream inflammatory factors such as TNF-α and IL-1α, reducing the triggering of inflammation at its source. Ferulic acid enhances the blocking effect of bisabolol and peony root extract on the inflammatory cascade by inhibiting the NFκB signaling pathway, thereby significantly reducing the expression of the IL-6 inflammatory factor.

[0017] 2. Ceramide NP and phytosphingosine have a synergistic effect. While supplementing intercellular lipids, they can promote the synthesis of endogenous ceramides, enhance the activity of skin superoxide dismutase, enable the skin to autonomously scavenge free radicals, and improve the skin's antioxidant capacity.

[0018] 3. Ferulic acid itself is a powerful aqueous antioxidant that can form a water-oil biphasic network with astaxanthin. Furthermore, through its chelation effect, it effectively stabilizes the easily inactivated astaxanthin, constructing a comprehensive antioxidant network covering both inside and outside the cell membrane, and effectively scavenging DPPH free radicals.

[0019] 4. The preparation method of the composition of the present invention has the advantages of being simple and easy to industrialize, and can effectively ensure the stability of the product and the activity of each active ingredient, and solve the problems of easy degradation of active ingredients and unstable formulation system. Detailed Implementation

[0020] To make the technical problems, solutions, and advantages of this invention clearer, a detailed description will be provided below with reference to specific examples. However, the scope of protection of this invention is not limited to the following specific embodiments. The described embodiments are merely some, not all, of the embodiments of this invention, and are not intended to limit the invention. Based on the embodiments of this invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this invention.

[0021] Unless otherwise defined, all technical terms used herein have the same meaning as commonly understood by those skilled in the art. The technical terms used herein are for the purpose of describing particular embodiments only and are not intended to limit the scope of the invention.

[0022] Unless otherwise specified, all raw materials, reagents, instruments and equipment used in this invention can be purchased from the market or prepared by existing methods.

[0023] In the quantitative experiments in the following examples, three replicate experiments were set up, and the data are the average of the three replicate experiments or the average ± standard deviation.

[0024] The present invention includes Examples 1 to 3 and Comparative Examples 1 to 11, and the specific components and contents are shown in Tables 1 to 2, in units of weight percentage.

[0025] Table 1

[0026] Table 2

[0027] Specifically, the preparation method of the above embodiments includes the following steps: S1.A phase preparation: accurately weigh each component of phase A into a container, stir and mix evenly, heat to 80℃ and keep warm, homogenize until a uniform gel is formed; S2.B phase preparation: accurately weigh each component of phase B into another container, heat to 80°C and stir until completely dissolved to form a homogeneous oil phase; S3. Emulsification: Under stirring, phase B is slowly added to phase A, and homogenized emulsification is carried out for 5 minutes. Then, the mixture is kept warm and stirred for 15 minutes to ensure that it is fully emulsified and uniform, thus obtaining material 1. S4.C phase preparation: Astaxanthin and ferulic acid are mixed at a weight ratio of 1: (6-10) to obtain a mixture. Then, 1,3-butanediol with a weight of 5-10 times the total weight of the mixture is added. The mixture is heated to 55-60℃ and stirred until completely dissolved. Then, the remaining 1,3-butanediol is added and mixed evenly. S5. Add phase D to the container in sequence to dissolve it in advance; add phase E to the container and heat it to 65-70℃ to dissolve it into a transparent solution; when the temperature of material 1 drops below 40℃, add the pre-dissolved phases C, D and E, stir evenly, then add phase F, adjust the pH of the system to 6.0, and continue stirring to cool down to below 30℃, and discharge the material to obtain the finished product.

[0028] Similarly, the preparation method for the comparative example can be obtained. If there are substances that are not added, they can be deleted in the corresponding preparation steps.

[0029] Experimental testing 140 volunteers aged 20-45 (70 with sensitive skin and 70 with early signs of aging skin) were selected and randomly divided into 14 groups, corresponding to Examples 1-3 and Comparative Examples 1-11, respectively.

[0030] All tests were conducted in a temperature and humidity controlled room at 21.0±1.0℃ and 50%±10%RH. Volunteers were required to sit quietly in this environment for at least 30 minutes to acclimatize.

[0031] Test area marking: Sample areas of equal size were delineated on both sides of the volunteer's cheeks, randomly distributed left and right to ensure statistical balance. Precise marking was performed using medical tape and a surgical pen.

[0032] General pre-test preparation: Do not use any cosmetics or topical medications on the test area for 3 days prior to the test. Before each test, cleanse the entire face with a uniform, gentle cleanser, rinse thoroughly with water, and gently pat dry with a lint-free tissue.

[0033] Sample method: Frequency and duration of use: Volunteers used the product twice daily, morning and evening, for 28 days. After cleansing in the morning and evening, the product was applied to the marked test areas.

[0034] Dosage and usage: Before each use, weigh 0.0300g ± 0.0020g (approximately equivalent to 2 mg / cm²) of sample using a precision balance. Using a disposable finger cot, apply the sample evenly to the entire marked test area and gently massage in circular motions in the same direction until fully absorbed.

[0035] Control group: If a blank control area is set up where no product is used, this area is only cleaned and no product is applied.

[0036] All the following tests strictly followed the above sampling method and were measured at the specified time points.

[0037] 1. Increase rate of stratum corneum water content Testing instrument: Corneometer CM825 moisture test probe Test principle: Based on the principle of capacitance, the change in the dielectric constant of the skin is measured to reflect the degree of hydration of the stratum corneum.

[0038] Test method: After volunteers sat still, the probe was placed vertically in the marked area. The measurement was performed three times in parallel for each area, and the average value was taken as the moisture content value at that time point. The stratum corneum moisture content was measured immediately after sample application and again 28 days after sample application, and recorded as D0 and D28, respectively.

[0039] Calculation formula: (D28 value - D0 value) / D0 value × 100%.

[0040] 2. Decrease in transepidermal water loss Testing instrument: Tewameter TM300 moisture loss probe Test principle: Based on Fick's law of diffusion, the transdermal water loss is reflected by testing the water vapor pressure gradient on the skin surface.

[0041] Test method: Place the probe tightly against the marked area, and record the steady-state value after the reading stabilizes. Measure each area three times and take the average. Measure the transdermal water loss value immediately after sample application and the transdermal water loss value remeasured 28 days after sample application, and record them as D0 and D28, respectively.

[0042] Calculation formula: D0 value - D28 value (a negative result indicates a decrease, and the absolute value indicates the degree of improvement).

[0043] 3. Decreased erythema index (a* value) Testing instrument: CK MPA580 skin tester with built-in spectrophotometer Test principle: By measuring the reflectance spectrum of the skin surface, the a value (red-green value) in the CIEL*a*b colorimetric system is calculated. The higher the positive value, the more obvious the erythema. The erythema index was tested immediately after application and again 28 days later, and recorded as D0 and D28, respectively.

[0044] Test method: Align the probe with the marked area, ensure constant pressure, and measure each area 3 times and take the average value.

[0045] Calculation formula: D0 value - D28 value (a negative result indicates a reduction in erythema, and the absolute value indicates the degree of improvement).

[0046] 4. DPPH free radical scavenging rate (%) Testing instrument: Ultraviolet-Vis spectrophotometer Test principle: DPPH free radicals have a characteristic absorption peak at 517nm. When neutralized by antioxidants, the absorbance decreases, and the degree of decrease is proportional to the scavenging ability.

[0047] Test Method: Test immediately after product preparation. Accurately transfer 0.1 mL of the sample solution and mix it with 3.0 mL of 0.2 mmol / L DPPH ethanol solution, vortex, and react in the dark for 30 minutes. Measure the absorbance (As) at 517 nm. Simultaneously measure the absorbance (Ac) of 0.1 mL of solvent and 3.0 mL of DPPH solution, and the absorbance (Ab) of 0.1 mL of sample solution and 3.0 mL of ethanol.

[0048] Calculation formula: Clearance rate (%) = [1 - (As - Ab) / Ac] × 100% 5. Subjective relief score (0-10 points) Using the Visual Analogue Scale (VAS), on day 28, volunteers marked their immediate feelings 30 minutes after using the product on a ruler marked with a score from 0 to 10. A score of 0 indicated "no relief, increased stinging / redness," and a score of 10 indicated "complete relief, no discomfort." The average score for the entire group was recorded.

[0049] 6. Subjective Moisturizing Level Rating (0-10 points) Using the Visual Analogue Scale (VAS), volunteers rated their lasting hydration two hours after using the product on day 28. A score of 0 indicated "completely dry," and 10 indicated "continuously moisturized." The average score for the entire group was recorded.

[0050] 7. IL-6 inflammatory factor inhibition rate (%) Test principle: ELISA (Enzyme-Linked Immunosorbent Assay) uses specific antibodies to quantitatively detect IL-6 in skin tissue fluid samples.

[0051] Test method: Collect skin tissue fluid from the marked area using a non-invasive skin irrigation or adsorption method. Strictly follow the ELISA kit instructions and calculate the IL-6 concentration using a standard curve.

[0052] Calculation formula: (D0 concentration - D28 concentration) / D0 concentration × 100% 8. SOD activity enhancement rate (%) Test principle: Chemical colorimetric method (such as WST-8 method). SOD can inhibit the colorimetric reaction mediated by superoxide anion free radicals, and its activity is directly proportional to the inhibition rate.

[0053] Test method: Skin keratinocytes were collected using a non-invasive adhesive tape peeling method. After protein extraction, the cells were reacted with a chromogenic working solution, and the absorbance was measured at a wavelength of 450 nm to calculate SOD activity.

[0054] Calculation formula: (D28 activity - D0 activity) / D0 activity × 100% 9. Astaxanthin stability test Testing instrument: High-performance liquid chromatograph (HPLC) Test principle: Astaxanthin in a mixture is separated by a chromatographic column, and its peak area at a specific wavelength is measured by a detector. The astaxanthin content is then quantitatively calculated using the external standard method.

[0055] Test method: The products of Example 2 and Comparative Example 7 were placed in a constant temperature and humidity chamber at 40℃±2℃ and 75%RH±5%RH for accelerated stability testing. Samples were taken at 0 days, 7 days, 15 days and 30 days, accurately weighed, and the astaxanthin in the samples was extracted with an appropriate solvent. After filtration, the samples were injected into HPLC for analysis.

[0056] Calculation formula: Astaxanthin retention rate (%) = (Astaxanthin content in the sample on day Tn / Astaxanthin content in the sample on day T0) × 100% The specific test results are shown in Table 3.

[0057] Table 3

[0058] The test results of Examples 1 to 3 show that the composition of the present invention has the functions of soothing and anti-inflammatory, repairing the skin barrier, and anti-oxidation.

[0059] Comparing the test results of Example 2 with those of Comparative Examples 1-5, it can be seen that the effects of adding bisabolol, peony root extract, and ferulic acid simultaneously are better than adding any two or three of them without adding them. This indicates that bisabolol, peony root extract, and ferulic acid have a synergistic effect and together they constitute a multi-target anti-inflammatory pathway. The absence of a single component will significantly weaken the overall soothing effect of the composition.

[0060] A comparison of the test results of Example 2 and Comparative Example 6 shows that when bisabolol is replaced with an equal amount of dipotassium glycyrrhizate, the soothing and repair indicators (such as IL-6 inhibition rate and transdermal water loss) are significantly lower than those of Example 2. This indicates that even if another known effective soothing ingredient is used as a replacement, the synergistic anti-inflammatory effect of the specific combination of the present invention (bisabolol, peony root extract, ferulic acid) cannot be achieved, proving the uniqueness and irreplaceability of the component selection of this complex.

[0061] Comparing the test results of Example 2 with those of Comparative Examples 7-9, it can be seen that compared with adding either ceramide NP or phytosphingosine alone or without adding either, the simultaneous addition of ceramide NP and phytosphingosine resulted in better reduction of transdermal water loss, increase in stratum corneum water content, and subjective moisturization score, indicating that ceramide NP and phytosphingosine have a synergistic effect.

[0062] A comparison of the test results of Example 2 with Comparative Examples 4 and 10-11 shows that Example 2 exhibited the highest DPPH scavenging rate (85.5%), while the DPPH scavenging rate of Comparative Example 10 decreased sharply. The astaxanthin retention rate of Comparative Example 4 (40.5%) was significantly lower than that of Example 2 (90.8%), demonstrating the excellent stabilizing effect of ferulic acid on astaxanthin. The DPPH scavenging rate of Comparative Example 11 (40.0%) was contributed by ferulic acid, but it was significantly lower than that of Example 2 (85.5%). This indicates that although ferulic acid is a powerful aqueous antioxidant, the lack of fat-soluble astaxanthin severely restricts the overall free radical scavenging ability of the composition. Therefore, astaxanthin and ferulic acid are indispensable in synergistically enhancing the overall antioxidant efficacy (DPPH scavenging rate).

[0063] Comparative Example 10, lacking the antioxidant complex, showed similar soothing and repair indicators (such as IL-6 inhibition rate and transdermal water loss) to Example 2, but its antioxidant (DPPH clearance rate) and soothing score (due to the potential indirect exacerbation of inflammation caused by the lack of antioxidants) were worse. Conversely, the antioxidant capacity (SOD activity and DPPH clearance rate) of groups lacking either the soothing or repair complex was not significantly affected. This indicates that the three complexes function in their respective areas, collectively contributing to the product's overall efficacy.

[0064] The preferred embodiments of the present invention have been described in detail above. However, the present invention is not limited to the specific details in the above embodiments. Within the scope of the technical concept of the present invention, various simple modifications can be made to the technical solution of the present invention, and these simple modifications all fall within the protection scope of the present invention.

[0065] It should also be noted that the various specific technical features described in the above embodiments can be combined in any suitable manner without contradiction. To avoid unnecessary repetition, the present invention will not describe the various possible combinations separately.

[0066] Furthermore, various different embodiments of the present invention can be combined in any way, as long as they do not violate the spirit of the present invention, they should also be regarded as the content disclosed by the present invention.

Claims

1. A skincare composition with soothing, repairing, and antioxidant functions, characterized in that, It includes the following components by weight percentage: 0.38–1.5% soothing and anti-inflammatory complex, 2.2–4.8% barrier repair complex, 0.35–1.45% antioxidant complex, 1.0–9.8% moisturizer, 1.5–5% emulsifier, 0.2–0.7% thickener, 1–6% silicone oil conditioner, 0.9–1.8% preservative, 0.03–0.08% chelating agent, 0.05–0.2% pH adjuster, and the balance being water; The soothing and anti-inflammatory complex includes bisabolol, peony root extract, and ferulic acid; the barrier repair complex includes squalane, ceramide NP, and phytosphingosine; and the antioxidant complex includes astaxanthin and ferulic acid.

2. The skincare composition with soothing, repairing, and antioxidant functions according to claim 1, characterized in that, The mass ratio of bisabolol, peony root extract, and ferulic acid is (0.5-2):(0.1-1):(1-10); the mass ratio of squalane, ceramide NP, and phytosphingosine is (5-20):(0.5-5):(0.5-3); and the mass ratio of astaxanthin and ferulic acid is (0.5-2):(5-20).

3. The skincare composition with soothing, repairing, and antioxidant functions according to claim 1, characterized in that, The moisturizer includes at least one of glyceryl polyether-26, 1,3-butanediol, D-panthenol, and sodium hyaluronate cross-linked polymer; the molecular weight of the sodium hyaluronate cross-linked polymer is 1.0*10. 6 ~2.5*10 6 Da.

4. The skincare composition with soothing, repairing, and antioxidant functions according to claim 1, characterized in that, The emulsifier includes at least one of polyglycerol-10 stearate, polysorbate-80, hydrogenated lecithin, PEG-100 stearate, cetearyl alcohol polyether-20, dehydrated sorbitan oleate, and sorbitan oleate.

5. The skincare composition with soothing, repairing, and antioxidant functions according to claim 1, characterized in that, The thickener includes at least one of carbomer, carboxymethyl deacetylated chitosan, xanthan gum, sodium acrylate / sodium acryloyl dimethyl taurate copolymer, and hydroxyethyl cellulose.

6. The skincare composition with soothing, repairing, and antioxidant functions according to claim 1, characterized in that, The silicone oil conditioning agent includes at least one of polydimethylsiloxane, cetearyl polymethylsiloxane, cyclopentadimethylsiloxane, phenyl polytrimethylsiloxane, and cetearyl polydimethylsiloxane.

7. The skincare composition with soothing, repairing, and antioxidant functions according to claim 1, characterized in that, The preservative includes at least one of p-hydroxyacetophenone, phenoxyethanol, capryloyl hydroxamic acid, 1,2-hexanediol, 1,2-pentanediol, and ethylhexylglycerin.

8. The skincare composition with soothing, repairing, and antioxidant functions according to claim 1, characterized in that, The chelating agent includes disodium EDTA.

9. The skincare composition with soothing, repairing, and antioxidant functions according to claim 1, characterized in that, The pH adjuster includes arginine.

Images