Wearable and vibration-controlled nail base nanometer microneedle transdermal drug delivery device

Abstract

The present application relates to the technical field of medical apparatus, particularly relates to wearable and vibration control nail base nanocrystal microneedle transdermal drug delivery device, including shell, both sides of the shell are provided with a group of positioning notches respectively, a group of positioning notches are provided with a threaded hole respectively, the inside four corners of the shell are provided with a group of support seats respectively, still include controller assembly, nanocrystal microneedle assembly, vibration assembly, power supply assembly and fixed ring assembly, the controller assembly is detachably installed in the shell, the shell is provided with vibration assembly and battery assembly respectively, the bottom end of the shell is detachably provided with nanocrystal microneedle assembly, the both ends of the fixed ring assembly are detachably connected with a group of positioning notches respectively, the nanocrystal microneedle assembly is used for lightly pricking nail base epidermis and nail plate edge to form microchannel, the power supply assembly provides power for vibration assembly and controller assembly;It makes drug directly contact focus.

Description

Technical Field

[0001] This invention relates to the technical field of medical devices, and in particular to a wearable transdermal drug delivery device for the nail root nanocrystal microneedles with vibration control. Background Technology

[0002] Onychomycosis is a common dermatofungal infection caused by fungal invasion of the nail plate, nail bed, or nail matrix. Paronychia and other nail root diseases have long faced treatment challenges. Current clinical practice mainly relies on oral antifungal drugs and topical medications, both of which have insurmountable technical limitations.

[0003] While oral antifungal drugs have some efficacy, they need to work through the whole body. Long-term use can easily cause liver damage and drug interactions, and poses safety risks to children, the elderly, and patients with liver and kidney dysfunction, thus limiting their application.

[0004] Topical medications are generally safe, but their delivery efficiency is extremely low due to the physiological barriers of the nail bed: First, the nail plate is composed of dense keratin and the nail root has a thick keratin layer, making it difficult for medications (especially large molecule medications) to penetrate into key lesions such as the nail matrix and nail bed. Treatment cycles often last for several months to more than a year, with limited efficacy. Second, the medication often remains on the nail surface or surrounding skin, resulting in insufficient concentration at the lesion site, which can easily lead to fungal resistance. Local accumulation can also cause irritation, and frequent reapplication wastes medication. Third, the long treatment course and cumbersome medication use reduce patient compliance, and improper medication use leads to a high recurrence rate, creating a vicious cycle. Fourth, the long-term low drug concentration environment at the lesion site can easily induce fungal resistance, ultimately leading to treatment failure.

[0005] In summary, existing methods have significant bottlenecks in drug delivery efficiency, treatment safety, and patient compliance. There is an urgent clinical need for a new drug delivery device that can overcome the nail barrier and achieve precise and efficient drug delivery. Summary of the Invention

[0006] To address the aforementioned technical problems, this invention provides a wearable and vibration-controlled transdermal drug delivery device for the nail root, which utilizes an ergonomically designed arc-shaped microneedle array and vibration assistance to achieve rapid and efficient drug penetration at the nail root, and features replaceable needles and multiple vibration adjustment functions.

[0007] The present invention relates to a wearable, vibration-controlled transdermal drug delivery device for the nail root using nanocrystal microneedles, comprising a housing, wherein a set of positioning slots are respectively provided on both sides of the housing, and each set of positioning slots is provided with a threaded hole of number 1; a set of support bases are respectively provided at the four corners of the inner side of the housing; and further comprising a controller assembly, a nanocrystal microneedle assembly, a vibration assembly, a power supply assembly, and a fixing ring assembly. The controller assembly is detachably installed inside the housing, and the vibration assembly and battery assembly are respectively provided inside the housing. The nanocrystal microneedle assembly is detachably installed at the bottom of the housing, and the two ends of the fixing ring assembly are detachably connected to a set of positioning slots. The nanocrystal microneedle assembly is used to gently puncture the nail root epidermis and the edge of the nail plate to form a microchannel. The power supply assembly provides power to the vibration assembly and the controller assembly. In use, the required medication is applied to the outer surface of the patient's nail root. The fixing ring assembly is then fitted onto the corresponding finger, allowing the nanocrystal microneedle assembly to be precisely aligned with the junction area between the nail root skin and the nail plate. The vibration assembly is activated by the controller assembly, which drives the nanocrystal microneedle assembly to gently puncture the junction area to form a microchannel. The medication enters the nail matrix and nail bed tissue through the vibration and microchannels, improving the efficiency of the medication passing through the nail plate and nail root skin, allowing the medication to directly contact the lesion.

[0008] Preferably, the controller assembly includes a controller body, a first threaded groove, and a touch screen. The top of the controller body is equipped with the touch screen, the bottom of the controller body is equipped with the first threaded groove, and the bottom of the housing is equipped with a first countersunk hole. A set of first bolts passes through the first countersunk hole. During installation, the controller body is placed inside the housing, and four sets of support seats cooperate to support and position the controller body. At this time, the first threaded groove coincides with the first countersunk hole, and the first bolt passes through the first countersunk hole and is threadedly connected to the first threaded groove, thereby completing the fixation of the controller body. The controller body is connected to the battery assembly and the vibration assembly respectively. Medical personnel start and stop the vibration assembly through the touch screen on the controller body, so that the nanocrystalline microneedle assembly can gently puncture the junction area to form microchannels.

[0009] Preferably, the fixing ring assembly includes a fixing ring body, a first circular hole, a positioning plate, a second circular hole, and a second bolt. The fixing ring body has a first circular hole at each end. There are two sets of positioning plates, each set having a set of second circular holes. A set of second bolts passes through each set of first circular holes. The fixing ring body is made of an elastic material. The two ends of the fixing ring body are placed into a set of positioning slots, aligning the first circular hole with the first threaded hole in the positioning slot. Then, the second bolt passes through the second and first circular holes on the positioning plate and is threaded into the first threaded hole, thus fixing the fixing ring body. In use, the fixing ring body is fitted onto the patient's finger. The fixing ring body's elasticity causes the nanocrystalline microneedle assembly to contact the junction area. When the vibration component is activated, the nanocrystalline microneedle assembly gently pricks the junction area.

[0010] Preferably, the nanocrystalline microneedle assembly includes a positioning frame, positioning blocks, a second threaded groove, a mounting base, nanocrystalline microneedle bodies, a third circular hole, a third bolt, and a fixing plate. Two sets of positioning frames are provided at the bottom of the housing. The bottom of the mounting base has an arc-shaped concave portion, on which multiple sets of nanocrystalline microneedle bodies are arranged in an array. The bottom ends of the multiple sets of nanocrystalline microneedle bodies form an arc-shaped concave surface. Two sets of positioning blocks are provided at the rear end of the mounting base, and the positioning blocks are adapted to the positioning frames. A fixing plate is provided at the front end of the mounting base, and a third circular hole is provided on the fixing plate. A second threaded groove is provided at the bottom of the housing, and a set of third bolts passes through the third circular hole. During installation, the two... The positioning blocks are inserted into the inner side of the corresponding positioning frame. Then, the No. 3 circular hole is aligned with the No. 2 threaded groove. The No. 3 bolt is passed through the No. 3 circular hole and threaded into the No. 2 threaded groove, thus completing the fixed installation of the mounting base and the nanocrystal microneedle body. The arc-shaped concave surface is adapted to the junction area. When the vibration component drives the multiple sets of nanocrystal microneedle bodies to vibrate, the multiple sets of nanocrystal microneedle bodies lightly puncture the junction area, so that the drug can directly contact the lesion through the microchannel. After the operation is completed, the fixing ring body is removed from the finger, the No. 3 bolt is unscrewed, and then the mounting base and nanocrystal microneedle body are removed and discarded together. Another set of mounting bases and nanocrystal microneedle bodies are reinstalled to avoid cross-infection between different patients.

[0011] Preferably, the vibration assembly consists of two sets, each including a miniature DC vibration motor, a mounting base, and locking bolts. The mounting base is equipped with the miniature DC vibration motor and is fixedly installed at the bottom of the housing via the locking bolts. Both sets of miniature DC vibration motors are connected to the main body of the controller. After the medication is applied to the junction area, the fixing ring is placed on the finger, and the two sets of miniature DC vibration motors are activated via the touch screen. The two sets of miniature DC vibration motors rotate synchronously to generate vibration, causing the mounting base to drive multiple sets of nanocrystalline microneedles to vibrate synchronously. This allows the nanocrystalline microneedles to gently puncture the junction area, forming microchannels and promoting direct contact between the medication and the lesion through the microchannels.

[0012] Preferably, the power supply assembly includes a card frame, a charging interface, and a battery body. The card frame is located inside the housing, and the battery body is located inside the card frame. The charging interface is located on the housing, and a motherboard is located inside the housing. The motherboard integrates a power management circuit. The charging interface is electrically connected to the power management circuit on the motherboard, and the power management circuit is electrically connected to the battery body. The charging interface receives power and charges the battery body. In use, the operator plugs a charging cable into the charging interface, so that the charging interface, in cooperation with the motherboard and the power management circuit, stores power in the battery body. The power stored in the battery body supplies power to the micro DC vibration motor and the controller body, improving the portability of the device.

[0013] Preferably, the main body of the fixing ring is made of medical-grade silicone. The main body of the fixing ring is made of silicone, which is less likely to cause adverse reactions such as allergies and irritation when in long-term contact with the skin at the nail root. It is suitable for the daily wearing needs of patients, can deform slightly with finger movements, and fits tightly to the curved surface of the nail root, ensuring that the nanocrystal microneedles are always aligned with the lesion area, while avoiding the feeling of tightness when wearing it.

[0014] Preferably, the nanocrystal microneedle body has a length of 0.3mm-0.6mm and is made of medical-grade stainless steel. A length of 0.3mm-0.6mm allows for precise penetration of the 200-300μm thick keratin layer at the nail root, forming a drug penetration microchannel while avoiding puncture of the underlying nail matrix. This ensures drug delivery efficacy while preventing damage to the nail bed that could cause pain or infection. The medical-grade stainless steel nanocrystal microneedle body is less likely to cause allergies or corrosion with prolonged contact with the nail root skin and medication, making it suitable for repeated use. It also has sufficient mechanical strength, preventing the needle tip from bending or breaking, ensuring stable keratin puncture, and facilitating cleaning and disinfection.

[0015] Preferably, it also includes a rubber sealing sleeve, which is fitted on the outer side of the controller body; when the controller body is installed inside the housing, the rubber sealing sleeve seals the gap between the controller body and the housing, thereby improving the sealing performance.

[0016] Preferably, it also includes a concave groove, wherein the fixed plate is provided with a concave groove at the end away from the mounting base; when it is necessary to disassemble the mounting base and the nanocrystalline microneedle body, the worker's fingernail enters the concave groove and moves the fixed plate downward, thereby quickly separating the mounting base from the housing and improving disassembly efficiency.

[0017] Compared with existing technologies, the beneficial effects of this invention are as follows: During use, the required medication is applied to the outer surface of the nail root, and the fixing ring assembly is fitted onto the corresponding finger, allowing the nanocrystalline microneedle assembly to be precisely aligned with the junction area between the nail root skin and the nail plate. The vibration assembly is activated via the controller assembly, which drives the nanocrystalline microneedle assembly to gently puncture the junction area, forming microchannels. The medication enters the nail matrix and nail bed tissue through vibration and microchannels, improving the efficiency of medication penetration through the nail plate and nail root skin, allowing the medication to directly contact the lesion, significantly improving the penetration efficiency of the medication at the nail root, shortening the treatment cycle, increasing the convenience of self-use for patients, reducing dependence on medical institutions, reducing systemic side effects, and improving medication safety. Attached Figure Description

[0018] Figure 1 This is a schematic diagram of the isometric structure of the present invention;

[0019] Figure 2 This is a schematic diagram of the front structure of the present invention;

[0020] Figure 3 yes Figure 2 A partially enlarged structural diagram of section A in the middle;

[0021] Figure 4 This is an exploded structural diagram of the present invention;

[0022] Figure 5 This is an enlarged structural diagram of the controller body and the rubber sealing sleeve structure;

[0023] Figure 6 This is an enlarged structural diagram of the support base and charging interface, etc.

[0024] Figure 7 This is an enlarged structural diagram of the No. 1 bolt and the positioning frame, etc.

[0025] Figure 8 This is an enlarged structural diagram of the mounting base and the nanocrystalline microneedle body, etc.

[0026] Figure 9 yes Figure 8 A partially enlarged structural diagram of section B in the middle;

[0027] Figure 10 This is an enlarged structural diagram of the micro DC vibration motor and its mounting base.

[0028] Figure 11 This is an enlarged structural diagram of the shell and fixing plate, etc.

[0029] Figure 12 This is a front cross-sectional structural diagram of the present invention;

[0030] Figure 13 This is an exploded view of the fixed ring assembly.

[0031] In the attached diagram, the markings are as follows: 101, housing; 102, positioning groove; 103, threaded hole No. 1; 104, support base; 201, controller body; 202, threaded groove No. 1; 203, countersunk hole No. 1; 204, bolt No. 1; 205, touch screen display; 206, rubber sealing sleeve; 301, fixing ring body; 302, round hole No. 1; 303, positioning plate; 304, round hole No. 2; 305, bolt No. 2; 401, fixing... Position frame; 402, Positioning block; 403, No. 2 threaded groove; 404, Mounting base; 405, Nanocrystalline microneedle body; 406, No. 3 round hole; 407, No. 3 bolt; 408, Fixing plate; 409, Concave groove; 410, Arc-shaped concave part; 411, Arc-shaped concave surface; 501, Miniature DC vibration motor; 502, Fixing base; 503, Locking bolt; 601, Clip frame; 602, Charging interface; 603, Battery body. Detailed Implementation

[0032] To facilitate understanding of the present invention, a more complete description will be given below with reference to the accompanying drawings. The present invention can be implemented in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete. Example

[0033] like Figures 1 to 13 As shown, the wearable and vibration-controlled transdermal nail root nanocrystal microneedle drug delivery device of the present invention includes a housing 101. A set of positioning slots 102 are respectively provided on both sides of the housing 101, and a threaded hole 103 is respectively provided on each of the positioning slots 102. A set of support seats 104 are respectively provided at the four inner corners of the housing 101. It also includes a controller assembly, a nanocrystal microneedle assembly, a vibration assembly, a power supply assembly, and a fixing ring assembly. The controller assembly is detachably installed inside the housing 101. The vibration assembly and a battery assembly are respectively provided inside the housing 101. The nanocrystal microneedle assembly is detachably installed at the bottom of the housing 101. The two ends of the fixing ring assembly are detachably connected to a set of positioning slots 102. The nanocrystal microneedle assembly is used to gently puncture the nail root epidermis and the edge of the nail plate to form microchannels. The power supply assembly provides power to the vibration assembly and the controller assembly.

[0034] The controller assembly includes a controller body 201, a first threaded groove 202, a first countersunk hole 203, a first bolt 204, and a touch screen 205. The touch screen 205 is provided at the top of the controller body 201, the first threaded groove 202 is provided at the bottom of the controller body 201, and the first countersunk hole 203 is provided at the bottom of the housing 101. A set of first bolts 204 are inserted into the first countersunk hole 203.

[0035] The fixing ring assembly includes a fixing ring body 301, a first circular hole 302, a positioning plate 303, a second circular hole 304, and a second bolt 305. The fixing ring body 301 has first circular holes 302 at both ends. There are two sets of positioning plates 303, each set having a set of second circular holes 304. Each set of first circular holes 302 has a set of second bolts 305 inserted through it. The fixing ring body 301 is made of an elastic material.

[0036] The nanocrystalline microneedle assembly includes a positioning frame 401, a positioning block 402, a second threaded groove 403, a mounting base 404, a nanocrystalline microneedle body 405, a third circular hole 406, a third bolt 407, and a fixing plate 408. Two sets of positioning frames 401 are provided at the bottom of the housing 101. An arc-shaped concave portion 410 is provided at the bottom of the mounting base 404. Multiple sets of nanocrystalline microneedle bodies 405 are arranged in an array, with an array size of 3mm × 5mm, a spacing of 0.5mm between adjacent nanocrystalline microneedle bodies 405, and an array curvature radius of 5-7mm (adapting to the curved surface of an adult nail root). The bottom ends of the multiple sets of nanocrystalline microneedle bodies 405 form an arc-shaped concave surface 411 (the arc-shaped concave surface 411 is...). Figure 2 and Figure 3 The dotted line portion is composed of multiple sets of nanocrystalline microneedle bodies 405 with needle tips. The rear end of the mounting base 404 is provided with two sets of positioning blocks 402, which are adapted to the positioning frame 401. The front end of the mounting base 404 is provided with a fixing plate 408, which has a third circular hole 406. The bottom end of the housing 101 is provided with a second threaded groove 403. A set of third bolts 407 are inserted through the third circular hole 406. The nanocrystalline microneedle body 405 has a conical needle tip, and the needle tip surface is deposited with a nanocrystalline titanium dioxide layer by magnetron sputtering (this is prior art and will not be described again). The nanocrystalline particle size is 50-80nm, and the coating thickness is 60-80nm, which enhances the drug adsorption and penetration efficiency.

[0037] In this embodiment, the controller body 201 is placed inside the housing 101. Four sets of support seats 104 cooperate to support and position the controller body 201. At this time, the first threaded groove 202 coincides with the first countersunk hole 203, and the first bolt 204 passes through the first countersunk hole 203 and is threadedly connected to the first threaded groove 202, thereby completing the fixation of the controller body 201. The controller body 201 is connected to the battery assembly and the vibration assembly respectively. The two sets of positioning blocks 402 on the mounting base 404 are inserted into the inner side of the corresponding set of positioning frames 401. Then, the third round hole 406 coincides with the second threaded groove 403, and the third bolt 407 passes through the third round hole 406 and is threadedly connected to the second threaded groove 403, thereby completing the fixed installation of the mounting base 404 and the nanocrystalline microneedle body 405. The two ends of the fixing ring body 301 are respectively placed into a set of positioning slots 102, so that the first round hole 302 coincides with the first threaded hole 103 in the positioning slot 102. Then, the second bolt 305 passes through the second round hole 304 and the first round hole 302 on the positioning plate 303 and is threadedly connected to the first threaded hole 103, thereby completing the fixing of the fixing ring body 301. Apply the required medicine to the outer surface of the patient's nail root, and put the fixing ring body 301 on the patient's finger. Under the action of its own elasticity, the fixing ring body 301 causes multiple sets of nanocrystalline microneedle bodies 405 to come into contact with the junction area. The vibration component is activated by 105, so that the mounting base 404 drives multiple sets of nanocrystalline microneedle bodies 405 to gently puncture the junction area to form multiple sets of microchannels. The medicine comes into direct contact with the lesion through the microchannels. Example

[0038] like Figures 1 to 13 As shown, the wearable and vibration-controlled transdermal nail root nanocrystal microneedle drug delivery device of the present invention includes a housing 101. A set of positioning slots 102 are respectively provided on both sides of the housing 101, and a threaded hole 103 is respectively provided on each of the positioning slots 102. A set of support seats 104 are respectively provided at the four inner corners of the housing 101. It also includes a controller assembly, a nanocrystal microneedle assembly, a vibration assembly, a power supply assembly, and a fixing ring assembly. The controller assembly is detachably installed inside the housing 101. The vibration assembly and a battery assembly are respectively provided inside the housing 101. The nanocrystal microneedle assembly is detachably installed at the bottom of the housing 101. The two ends of the fixing ring assembly are detachably connected to a set of positioning slots 102. The nanocrystal microneedle assembly is used to gently puncture the nail root epidermis and the edge of the nail plate to form microchannels. The power supply assembly provides power to the vibration assembly and the controller assembly.

[0039] The controller assembly includes a controller body 201, a first threaded groove 202, a first countersunk hole 203, a first bolt 204, and a touch screen 205. The touch screen 205 is provided at the top of the controller body 201, the first threaded groove 202 is provided at the bottom of the controller body 201, and the first countersunk hole 203 is provided at the bottom of the housing 101. A set of first bolts 204 are inserted into the first countersunk hole 203.

[0040] The fixing ring assembly includes a fixing ring body 301, a first circular hole 302, a positioning plate 303, a second circular hole 304, and a second bolt 305. The fixing ring body 301 has first circular holes 302 at both ends. There are two sets of positioning plates 303, each set having a set of second circular holes 304. Each set of first circular holes 302 has a set of second bolts 305 inserted through it. The fixing ring body 301 is made of an elastic material.

[0041] The nanocrystalline microneedle assembly includes a positioning frame 401, a positioning block 402, a second threaded groove 403, a mounting base 404, a nanocrystalline microneedle body 405, a third circular hole 406, a third bolt 407, and a fixing plate 408. Two sets of positioning frames 401 are provided at the bottom of the housing 101. An arc-shaped concave portion 410 is provided at the bottom of the mounting base 404. Multiple sets of nanocrystalline microneedle bodies 405 are arranged in an array, with an array size of 3mm × 5mm, a spacing of 0.5mm between adjacent nanocrystalline microneedle bodies 405, and an array curvature radius of 5-7mm (adapting to the curved surface of an adult nail root). The bottom ends of the multiple sets of nanocrystalline microneedle bodies 405 form an arc-shaped concave surface 411 (the arc-shaped concave surface 411 is...). Figure 2 and Figure 3 The dotted line portion is composed of multiple sets of nanocrystalline microneedle bodies 405 with needle tips. The rear end of the mounting base 404 is provided with two sets of positioning blocks 402, which are adapted to the positioning frame 401. The front end of the mounting base 404 is provided with a fixing plate 408, which has a third circular hole 406. The bottom end of the housing 101 is provided with a second threaded groove 403. A set of third bolts 407 are inserted in the third circular hole 406. The nanocrystalline microneedle body 405 has a conical needle tip, and the needle tip surface is deposited with a nanocrystalline titanium dioxide layer by magnetron sputtering (this is prior art and will not be described again). The nanocrystalline particle size is 50-80nm, and the coating thickness is 60-80nm, which enhances drug adsorption and penetration efficiency.

[0042] The vibration assembly consists of two sets, each including a miniature DC vibration motor 501, a mounting base 502, and a locking bolt 503. The mounting base 502 is equipped with the miniature DC vibration motor 501, and the mounting base 502 is fixedly installed at the bottom of the inner end of the housing 101 by the locking bolt 503. The housing 101 controlling the two sets of miniature DC vibration motors 501 to rotate synchronously is existing technology and will not be described again.

[0043] The power supply assembly includes a frame 601, a charging interface 602, and a battery body 603. The frame 601 is located inside the housing 101, and the battery body 603 is disposed inside the frame 601. The charging interface 602 is mounted on the housing 101. A motherboard is located inside the housing 101, and the motherboard integrates a power management circuit. The charging interface 602 is electrically connected to the power management circuit on the motherboard, and the power management circuit is electrically connected to the battery body 603. The charging interface 602 receives power and charges the battery body 603, which is a lithium battery.

[0044] The fixing ring body 301 is made of medical-grade silicone; the nanocrystal microneedle body 405 has a length of 0.3mm-0.6mm and is made of medical-grade stainless steel or polymer nanocrystal coating material.

[0045] It also includes a rubber sealing sleeve 206, which is fitted on the outside of the controller body 201; it also includes a concave groove 409, which is provided at the end of the fixing plate 408 away from the mounting base 404.

[0046] In this embodiment, the controller body 201 is placed inside the housing 101. Four sets of support seats 104 cooperate to support and position the controller body 201. At this time, the first threaded groove 202 coincides with the first countersunk hole 203, and the first bolt 204 passes through the first countersunk hole 203 and is threadedly connected to the first threaded groove 202, thereby completing the fixation of the controller body 201. The controller body 201 is connected to the battery assembly and the vibration assembly respectively. The two sets of positioning blocks 402 on the mounting base 404 are inserted into the inner side of the corresponding set of positioning frames 401. Then, the third round hole 406 coincides with the second threaded groove 403, and the third bolt 407 passes through the third round hole 406 and is threadedly connected to the second threaded groove 202. The groove 403 is threaded to complete the fixed installation of the mounting base 404 and the nanocrystalline microneedle body 405. The two ends of the fixing ring body 301 are respectively placed into a set of positioning slots 102, so that the first round hole 302 coincides with the first threaded hole 103 in the positioning slot 102. Then, the second bolt 305 passes through the second round hole 304 and the first round hole 302 on the positioning plate 303 and is threaded to the first threaded hole 103, thus completing the fixing of the fixing ring body 301. The operator connects the charging cable to the charging interface 602, so that the charging interface 602, in cooperation with the motherboard and power management circuit, stores power in the battery body 603. The battery body 603 internally stores... The stored power supplies the micro DC vibration motors 501 and the controller body 201. The required medication is applied to the outer surface of the nail root. The fixing ring body 301 is then fitted onto the patient's finger. The fixing ring body 301, due to its elasticity, causes multiple sets of nanocrystalline microneedle bodies 405 to contact the interface area. Both sets of micro DC vibration motors 501 are wired to the controller body 201. After the medication is applied to the interface area, the fixing ring body 301 is fitted onto the finger. The two sets of micro DC vibration motors 501 are activated via the touch screen 205. The two sets of micro DC vibration motors 501 rotate synchronously, generating vibration, which causes the mounting base 404 to drive the multiple sets of nanocrystalline microneedle bodies 405. Synchronous vibration is applied to the nanocrystal microneedle body 405 to gently puncture the junction area, forming a microchannel that facilitates direct contact between the drug and the lesion. The fixing ring body 301 is made of silicone, which is less likely to cause allergies or irritation due to long-term contact with the skin at the nail root. It is suitable for patients' daily wear needs, and can deform slightly with finger movements, closely conforming to the curved surface of the nail root to ensure that the nanocrystal microneedle is always aligned with the lesion area, while avoiding a tight feeling during wear. The nanocrystal microneedle body 405, with a length of 0.3mm-0.6mm, can accurately penetrate the 200-300μm thick keratin layer at the nail root to form a drug penetration microchannel, while avoiding puncturing the underlying nail matrix (located 0.3mm below the keratin layer).(6mm or more) ensures drug delivery effectiveness while preventing damage to the nail bed that could cause pain or infection; the medical-grade stainless steel nanocrystal microneedle body 405 is less likely to cause allergies or corrosion with prolonged contact with the nail root skin and medication, making it suitable for repeated use; it has sufficient mechanical strength, the needle tip is not easily bent or broken, it can stably complete keratin puncture and is easy to clean and disinfect; the rubber sealing sleeve 206 seals the gap between the controller body 201 and the housing 101; after operation, the fixing ring body 301 is detached from the finger, the No. 3 bolt 407 is unscrewed, and the operator's fingernail enters the concave groove 409 to move the fixing plate 408 downward, thereby quickly separating the mounting base 404 from the housing 101, and installing another set of mounting bases 404 with the nanocrystal microneedle body 405, avoiding cross-infection between different patients; the controller body 201 adjusts the vibration frequency of the micro DC vibration motor 501 through the touch screen 205, which is existing technology and will not be described again.

[0047] The main functions achieved by this invention are:

[0048] 1. Structural design of nanocrystal microneedle components specifically for transdermal drug delivery to the nail root;

[0049] 2. Wearable fixing ring ensures stable contact between the nanocrystal microneedle body 405 and the nail root;

[0050] 3. Vibration component-assisted delivery technology improves the efficiency of drug penetration through the nail plate and nail root skin;

[0051] 4. Replaceable mounting base 404 and nanocrystalline microneedle body 405 reduce the risk of infection and allow for adjustment of needle length and layout according to lesions.

[0052] This invention relates to a wearable, vibration-controlled transdermal drug delivery device for the nail root using nanocrystalline microneedles. The touchscreen display 205 sets the vibration amplitude and duration of the micro-DC vibration motor 501. The fixing ring body 301 is also length-adjustable to accommodate different finger sizes. The installation, connection, and setup methods are all common mechanical methods; any method that achieves the desired beneficial effect can be implemented. The battery body 603 is wired to the micro-DC vibration motor 501 and the controller body 201. The controller body 201, touchscreen display 205, and nanocrystalline microneedle body 405 of this wearable, vibration-controlled transdermal drug delivery device for the nail root are commercially available. Those skilled in the art can install and operate the device simply by following the accompanying instruction manual, without requiring any creative effort from those skilled in the art.

[0053] The above description is only a preferred embodiment of the present invention. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the technical principles of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. A wearable transdermal drug delivery device for the nail root with vibration control, comprising a housing (101), wherein a set of positioning slots (102) are respectively provided on both sides of the housing (101), and a threaded hole (103) is respectively provided on each of the positioning slots (102), and a set of support seats (104) are respectively provided at the four corners of the inner side of the housing (101), characterized in that, It also includes a controller assembly, a nanocrystalline microneedle assembly, a vibration assembly, a power supply assembly, and a fixing ring assembly. The controller assembly is detachably installed inside the housing (101). The vibration assembly and the battery assembly are respectively installed inside the housing (101). The nanocrystalline microneedle assembly is detachably installed at the bottom of the housing (101). The two ends of the fixing ring assembly are detachably connected to a set of positioning slots (102). The nanocrystalline microneedle assembly is used to lightly puncture the epidermis of the nail root and the edge of the nail plate to form a microchannel. The power supply assembly provides power to the vibration assembly and the controller assembly. The nanocrystal microneedle assembly includes a positioning frame (401), a positioning block (402), a second threaded groove (403), a mounting base (404), a nanocrystal microneedle body (405), a third circular hole (406), a third bolt (407), and a fixing plate (408). Two sets of positioning frames (401) are provided at the bottom of the housing (101), and an arc-shaped concave portion is provided at the bottom of the mounting base (404). Multiple sets of nanocrystal microneedle bodies (405) are arranged in an array within the arc-shaped concave portion. The bottom of the multiple nanocrystal microneedle bodies (405) forms an arc-shaped concave surface. The rear end of the mounting base (404) is provided with two sets of positioning blocks (402). The positioning blocks (402) are adapted to the positioning frame (401). The front end of the mounting base (404) is provided with a fixing plate (408). The fixing plate (408) is provided with a third circular hole (406). The bottom end of the housing (101) is provided with a second threaded groove (403). A set of third bolts (407) are inserted in the third circular hole (406). The vibration assembly consists of two sets, each including a miniature DC vibration motor (501), a mounting base (502), and a locking bolt (503). The mounting base (502) is equipped with the miniature DC vibration motor (501) and is fixedly installed at the bottom of the inner part of the housing (101) by the locking bolt (503).

2. The wearable transdermal drug delivery device with vibration control for the nail root nanocrystal microneedles as described in claim 1, characterized in that, The controller assembly includes a controller body (201), a first threaded groove (202), a first countersunk hole (203), a first bolt (204), and a touch screen (205). The top of the controller body (201) is provided with a touch screen (205), the bottom of the controller body (201) is provided with a first threaded groove (202), the bottom of the housing (101) is provided with a first countersunk hole (203), and a set of first bolts (204) are inserted in the first countersunk hole (203).

3. The wearable transdermal drug delivery device with vibration control for the nail root nanocrystal microneedles as described in claim 1, characterized in that, The fixing ring assembly includes a fixing ring body (301), a first circular hole (302), a positioning plate (303), a second circular hole (304), and a second bolt (305). The fixing ring body (301) has a first circular hole (302) at each end. There are two sets of positioning plates (303), each set of positioning plates (303) has a set of second circular holes (304), and each set of first circular holes (302) has a set of second bolts (305). The fixing ring body (301) is made of elastic material.

4. The wearable transdermal drug delivery device with vibration control for the nail root nanocrystal microneedles as described in claim 1, characterized in that, The power supply assembly includes a frame (601), a charging interface (602), and a battery body (603). The frame (601) is disposed inside the housing (101), and the battery body (603) is disposed inside the frame (601). The charging interface (602) is disposed on the housing (101). A motherboard is disposed inside the housing (101), and a power management circuit is integrated on the motherboard. The charging interface (602) is electrically connected to the power management circuit on the motherboard, and the power management circuit is electrically connected to the battery body (603). The charging interface (602) receives power and charges the battery body (603).

5. The wearable transdermal drug delivery device with vibration control for the nail root nanocrystal microneedles as described in claim 3, characterized in that, The fixing ring body (301) is made of medical-grade silicone.

6. The wearable transdermal drug delivery device with vibration control for the nail root nanocrystal microneedles as described in claim 1, characterized in that, The nanocrystal microneedle body (405) has a length of 0.3mm-0.6mm, and the nanocrystal microneedle body (405) is made of medical stainless steel.

7. The wearable transdermal drug delivery device with vibration control for the nail root nanocrystal microneedles as described in claim 2, characterized in that, It also includes a rubber sealing sleeve (206), which is fitted on the outside of the controller body (201).

8. The wearable transdermal drug delivery device with vibration control for the nail root nanocrystal microneedles as described in claim 1, characterized in that, It also includes a concave groove (409), and the end of the fixing plate (408) away from the mounting base (404) is provided with a concave groove (409).

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