Traditional Chinese medicine eye pad as well as preparation method and application thereof

Abstract

The invention discloses a traditional Chinese medicine eye pad which is characterized by comprising a traditional Chinese medicine extract, a penetration enhancer and a carrier matrix, the traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 15 to 25 parts of radix rehmanniae praeparata, 12 to 20 parts of fructus lycii, 10 to 18 parts of fructus corni, 8 to 15 parts of herba dendrobii, 10 to 15 parts of radix angelicae sinensis, 5 to 10 parts of radix bupleuri, 8 to 12 parts of flos chrysanthemi, 6 to 10 parts of fructus tribuli, 5 to 8 parts of cortex albiziae and 1 to 2 parts of borneol; based on the theory that liver blood moistens eyes and kidney essence nourishes eyes in the traditional Chinese medicine, the effects of the ten traditional Chinese medicines form a synergistic effect through accurate matching, the physiological environment of eyes is fundamentally improved, the influence of emotion on eyesight is also considered, and finally the double eye protection effect of nourishing the body constitution and protecting the surface is achieved.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine for eye care, and in particular to a traditional Chinese medicine eye patch, its preparation method, and its application. Background Technology

[0002] With the development of modern society, the frequency of use of electronic products (computers, mobile phones, televisions, etc.) is increasing. The light emitted from their screens and the characteristics of prolonged close-range viewing can cause eye dryness, eye irritation, and nearsightedness. Therefore, to relieve eye fatigue, eye patches have become a commonly used eye care product. Eye patches are used to relieve eye fatigue, moisturize the eyes, and relieve dryness. They are suitable for people who use their eyes extensively and those with uncomfortable symptoms such as dryness, itching, and soreness in their eyes.

[0003] However, existing eye patches work by interacting directly with the physiological mechanisms of the eyes through the active ingredients within the patch (e.g., adding chamomile or green tea extracts to relieve eye fatigue). Therefore, while existing eye patches may offer some relief from eye strain, their effects are only temporary and do not address the root cause. The relief is not long-lasting, the eye-care ingredients are limited in their efficacy, and they fail to address the underlying causes of eye fatigue.

[0004] Therefore, it is important to study a traditional Chinese medicine eye patch, its preparation method, and its application. Summary of the Invention

[0005] In view of the shortcomings of the prior art, the purpose of this invention is to provide a traditional Chinese medicine eye patch, its preparation method and application. Based on the theory of "liver blood nourishing the eyes and kidney essence nourishing the eyes" in traditional Chinese medicine, the invention uses precise proportions to combine the effects of 10 Chinese herbs to achieve a synergistic effect. This not only fundamentally improves the physiological environment of the eyes, but also takes into account the impact of emotions on vision, ultimately achieving a dual eye care effect of "nourishing the root and protecting the surface". This invention solves the problems of existing eye patches, such as short-lasting relief, single efficacy of eye care ingredients, and inability to fundamentally solve the deep-seated causes of eye fatigue.

[0006] The technical solution of the present invention is as follows:

[0007] A traditional Chinese medicine eye patch, comprising: a traditional Chinese medicine extract, a penetration enhancer, and a carrier matrix; the traditional Chinese medicine extract comprises, by weight, the following raw materials: 15-25 parts of Rehmannia glutinosa, 12-20 parts of Lycium barbarum, 10-18 parts of Cornus officinalis, 8-15 parts of Dendrobium nobile, 10-15 parts of Angelica sinensis, 5-10 parts of Bupleurum chinense, 8-12 parts of Chrysanthemum morifolium, 6-10 parts of Tribulus terrestris, 5-8 parts of Albizia julibrissin bark, and 1-2 parts of Borneol.

[0008] Optionally, the penetration enhancer comprises the following raw materials in parts by weight: 2-3 parts menthol, 0.5-1 parts azone, and 1-2 parts chitosan.

[0009] Optionally, the penetration enhancer comprises the following raw materials in parts by weight: 2-3.5 parts menthol lactate, 1.5-2.5 parts eucalyptus oil, 0.5-1.2 parts lauryl acetone, 3-5 parts propylene glycol, 1-1.8 parts sodium hyaluronate, and 0.8-1.5 parts xanthan gum.

[0010] Optionally, the carrier matrix comprises the following raw materials by weight: 15-20 parts gelatin, 2-4 parts sodium alginate, 5-8 parts glycerin, 1-2 parts polyvinylpyrrolidone, and an appropriate amount of purified water.

[0011] Optionally, the carrier matrix comprises the following raw materials by weight: 12-18 parts carrageenan, 10-15 parts hydroxypropyl methylcellulose, 2-3.5 parts pectin, 1.5-3 parts gum arabic, 4-7 parts 1,3-propanediol, 3-6 parts panthenol, 1-1.8 parts povidone K30, 0.8-1.5 parts guar gum, and an appropriate amount of purified water.

[0012] A second aspect of the present invention provides a method for preparing the aforementioned traditional Chinese medicine eye patch, characterized by comprising the following steps:

[0013] S1. Preparation of Chinese herbal medicine mixture: After mixing and stirring the Chinese herbal medicine extract with the penetration enhancer evenly, a Chinese herbal medicine mixture is obtained and set aside for later use;

[0014] S2. Preparation of β-cyclodextrin inclusion complex: Add the traditional Chinese medicine mixture from step S1 to β-cyclodextrin, mix and stir evenly, and finally solidify by refrigeration to obtain β-cyclodextrin inclusion complex for later use;

[0015] S3. Preparation of nanoliposome mixture: The β-cyclodextrin inclusion complex from step S2 is added to the homogenized lipid membrane and mixed evenly. Finally, the mixture is obtained by ultrasonic treatment and set aside for later use.

[0016] S4. Preparation of carrier matrix: Take the carrier matrix material and prepare it into a carrier matrix for later use;

[0017] S5. Preparation of traditional Chinese medicine eye patch: Take the nanoliposome mixture from step S3 and slowly add it to the carrier matrix from step S4. After stirring evenly, homogenize to obtain the traditional Chinese medicine eye patch.

[0018] Optionally, step S2 includes the following sub-steps:

[0019] S21. Preparation of saturated aqueous solution of β-cyclodextrin: Add β-cyclodextrin to deionized water, stir to dissolve, and form an aqueous solution of β-cyclodextrin with a mass concentration of 8-12%;

[0020] S22. Inclusion reaction: The traditional Chinese medicine mixture from step S1 is slowly added dropwise to the β-cyclodextrin aqueous solution while stirring. After the addition is complete, the mixture is stirred at a constant temperature for 2-3 hours to obtain the inclusion solution.

[0021] S23. Cold refrigeration and solidification: Place the inclusion solution from step S22 in a refrigerator for 12-24 hours to allow the inclusion compound to crystallize and precipitate.

[0022] S24. Separation and drying: First, the inclusion complex precipitate is separated by vacuum filtration or centrifugation. Then, it is washed with anhydrous ethanol to remove the unincluded volatile components. Finally, it is dried in a vacuum drying oven for 1-3 hours to obtain the β-cyclodextrin inclusion complex.

[0023] Optionally, in step S3, the mass ratio between the β-cyclodextrin inclusion complex and the homogeneous lipid membrane is 1:1 to 3:1.

[0024] Optionally, step S4 includes the following sub-steps:

[0025] S41. Pretreatment: Soak gelatin in deionized water for 20-40 minutes to allow it to fully swell; disperse sodium alginate in deionized water, stir until there are no particles, and let it stand to remove bubbles;

[0026] S42. Heating to dissolve: Place the swollen gelatin from step S41 in a constant temperature water bath, stir until completely dissolved, add glycerin, and continue stirring for 8-12 minutes to form a gelatin-glycerin solution;

[0027] S43. Composite thickening: Slowly add the sodium alginate dispersion from step S41 to the gelatin-glycerol solution from step S42, heat and stir to mix the system evenly and form a preliminary gel system;

[0028] S44. Adhesion and reinforcement: Add polyvinylpyrrolidone to step S43 and stir for 15-25 minutes to ensure that the adhesive is completely dispersed and to avoid the formation of particles;

[0029] S45. Thickening and Volume Adjustment: Add the remaining deionized water to step S44, stir, and adjust the gel consistency to 8000-10000 mPa·s to obtain the carrier matrix. Keep it at 40-50℃ for later use.

[0030] In a third aspect of the present invention, the application of the traditional Chinese medicine eye patch in eye masks and eye films is described.

[0031] Optionally, the herbal eye patch is used during the evening (twilight period) to nourish the liver and kidneys, replenish liver blood, relieve eye fatigue, and prevent myopia.

[0032] The beneficial effects of this application are as follows:

[0033] 1. This application takes "harmonizing the liver and kidneys, replenishing qi and blood, and enhancing transdermal efficacy" as its core logic. Through precise formulation, it combines the effects of 10 Chinese herbs to achieve synergistic effects, which not only fundamentally improves the physiological environment of the eyes, but also takes into account the impact of emotions on vision, ultimately achieving a dual eye protection effect of "nourishing the root and protecting the surface"; and fundamentally alleviating a variety of eye problems.

[0034] 2. Through the synergistic effect of Chinese herbal extracts and penetration enhancers, not only can the body's absorption of Chinese herbal extracts be improved, but also the Chinese herbal eye patches can meet the requirements of being non-irritating to the skin, having a matching penetration efficiency, and being suitable for sensitive skin around the eyes.

[0035] 3. Through the synergistic effect of Chinese herbal extracts and carrier matrix, the Chinese herbal eye patches have the advantages of good fit to the eyes, no allergenicity, and more stable use. Attached Figure Description

[0036] Figure 1 The image shows the transmission electron microscope results from Experiment Example 1.

[0037] Figure 2 The image shows the results of scanning electron microscopy in Experiment Example 1.

[0038] Figure 3 This is a photograph of the actual herbal eye patch used in the example. Detailed Implementation

[0039] Currently, there are many types of eye patches on the market, including: "moisturizing and hydrating, soothing and anti-fatigue, cold compress, hot compress, medicated, whitening and spot-fading, etc." All of these eye patches relieve eye fatigue by interacting with the active ingredients within the patch and the physiological mechanisms of the eye. While they have some effect, they also have drawbacks such as short-lived effects, inability to address underlying eye problems, and potential allergic reactions. Details are as follows:

[0040] Issue 1: Short-lasting effect: Eye patches work by applying active ingredients to the eyes, which can temporarily relieve fatigue, but cannot fundamentally change eye habits or the physiological state of the eyes. For example, cooling ingredients such as menthol only stimulate nerves to produce a temporary cooling sensation, and have no real improvement on tear film stability and meibomian gland function. The effect usually weakens after ten minutes or so, making it difficult to provide long-term, continuous eye care.

[0041] Question 2: Limited efficacy of eye care ingredients: Most eye patches are designed for only a single symptom, such as primarily focusing on relieving eye fatigue, lacking comprehensive conditioning for eye health. This makes it difficult to meet the specific eye needs of different groups, such as children and adolescents (whose eyes are still developing and whose eye habits are yet to be established) and middle-aged and elderly people (who often have degenerative eye diseases).

[0042] Problem 3: Treating the symptoms but not the root cause: It cannot fundamentally solve the underlying causes of eye fatigue; the effects of existing eye patches often only provide immediate relief, such as the fatigue returning after the cooling sensation subsides, and the moisturizing effect of artificial tears can only last for a few hours, after which the problem of dry eyes will still occur.

[0043] The inventors discovered that using traditional Chinese medicine eye patches can address these drawbacks. Based on this, the purpose of this embodiment is to provide a traditional Chinese medicine eye patch with the core logic of "harmonizing the liver and kidneys, nourishing both qi and blood, and enhancing transdermal efficacy." Through precise formulation, the effects of 10 traditional Chinese medicines are synergistically combined to fundamentally improve the physiological environment of the eyes while also considering the impact of emotions on vision, ultimately achieving a dual eye-protecting effect of "nourishing the root and protecting the surface," fundamentally alleviating various eye problems.

[0044] The core logic mentioned above is as follows:

[0045] First, when liver blood is sufficient, it can continuously provide moisture and nutrients to the cornea and conjunctiva of the eye surface, maintain tear film stability, and reduce dry eyes and stinging. At the same time, it nourishes the ciliary muscle (the muscle that controls the lens's accommodation), making it flexible and able to quickly adjust focus when looking at near and far objects, making it less likely to experience blurred vision or eye strain. Moreover, the normal functioning of retinal photoreceptor cells depends on the nourishment of liver blood. When liver blood is sufficient, photoreceptor cells react sensitively, resulting in clear vision.

[0046] II. Transdermal Enhancement: When liver blood is sufficient, kidney essence can nourish the macula of the retina (responsible for central vision) and the optic nerve. These two areas are the "core functional areas" of the eye. When kidney essence is sufficient, the photoreceptor cells in the macula are strong and the optic nerve conduction is smooth, making it less likely to cause visual distortion or visual field defects. If kidney essence is deficient (such as with age or long-term fatigue that depletes kidney essence), it will lead to insufficient nutrition to the fundus, which may cause blurred vision and sensitivity to light. The "presbyopia" and "blurred vision" common in middle-aged and elderly people are also closely related to the gradual decline of kidney essence.

[0047] Third, the addition of penetration enhancers opens the "absorption channels" of the skin around the eyes, significantly improving the transdermal absorption rate of the herbal extracts.

[0048] In this embodiment, the herbal eye patch comprises: herbal extract, penetration enhancer and carrier matrix; the herbal extract comprises the following raw materials by weight: 15-25 parts of Rehmannia glutinosa, 12-20 parts of Lycium barbarum, 10-18 parts of Cornus officinalis, 8-15 parts of Dendrobium nobile, 10-15 parts of Angelica sinensis, 5-10 parts of Bupleurum chinense, 8-12 parts of Chrysanthemum morifolium, 6-10 parts of Tribulus terrestris, 5-8 parts of Albizia julibrissin bark, and 1-2 parts of Borneol.

[0049] Among them, Rehmannia glutinosa (15-25 parts, the highest proportion): as the principal herb, it lays the foundation of "nourishing yin and replenishing blood, benefiting essence and filling marrow". It indirectly provides the source of liver blood by replenishing kidney essence (the kidney stores essence, and essence can generate blood). Especially in response to the physiological law of "kidney meridian is in charge at You time", the use at this time can maximize the efficiency of kidney essence nourishment and fundamentally provide "energy reserves" for the eyes.

[0050] Goji berries (12-20 parts) and dendrobium (8-15 parts): The dosage of these two ingredients closely follows that of prepared rehmannia root, forming a core combination for "dual nourishment of the liver and kidneys." Goji berries directly "nourish the liver and kidneys, benefit essence and improve eyesight," specifically replenishing liver blood; dendrobium "nourishes yin and improves eyesight," enhancing the eyes' tolerance to light and fatigue. Together, they strengthen the effect of "nourishing the eyes with essence and blood," relieving dry eyes and blurred vision.

[0051] Cornus officinalis (10-18 parts): By “tonifying the liver and kidneys, astringing essence and consolidating the body”, it reduces the dissipation of kidney essence and ensures that the essence and blood replenished by Rehmannia glutinosa and Lycium barbarum can stably act on the eyes, avoiding “tonification without consolidation”, and further consolidating the foundation for eye protection.

[0052] Angelica sinensis (10-15 parts): With "nourishing blood and promoting blood circulation" as its core, it not only replenishes insufficient liver blood but also promotes blood circulation, allowing the essence and blood replenished by Rehmannia glutinosa, Lycium barbarum, etc. to reach the eyes smoothly, solving the problems of "blurred vision due to blood deficiency and dry vision due to blood stasis", improving microcirculation in the eyes, and relieving eye fatigue and dark circles.

[0053] Bupleurum (5-10 parts) and Albizia bark (5-8 parts): Both are used in mild doses to address the problem of "emotional depletion of blood and liver damage." Bupleurum "soothes the liver and relieves depression," alleviating anxiety and irritability in the evening (avoiding "anger damaging the liver" and causing liver blood depletion); Albizia bark "relieves depression and calms the mind," stabilizing emotional fluctuations and reducing eye muscle tension and blurred vision caused by emotional stress, thus reducing the burden on the eyes from an "emotional level."

[0054] Chrysanthemum (8-12 parts) and Tribulus terrestris (6-10 parts): Both focus on "local eye regulation". Chrysanthemum "soothes the liver and brightens the eyes, clears the head and eyes", directly addressing the stimulation of the eyes caused by changes in light (such as the weakening of light at dusk and blue light from electronic screens); Tribulus terrestris "soothes the liver and relieves depression, brightens the eyes and stops dizziness", improving the regulatory function of eye muscles and relieving soreness and dizziness after prolonged use of the eyes. The two work together to "soothe the liver and brighten the eyes", taking into account both emotional and local eye discomfort.

[0055] Borneol (1-2 portions, the smallest but crucial amount): As a "guide drug", it opens the skin's penetration channels with the effect of "opening the orifices and brightening the eyes", promoting the absorption of the effective ingredients of the other 10 Chinese medicines through the skin around the eyes. This allows the effects of "tonifying the liver and kidneys, nourishing blood, and soothing the liver" to act on the eyes more quickly and directly, greatly improving the overall eye care effect and avoiding the problem of "medicine not reaching the eyes".

[0056] The traditional Chinese medicine formula in this application has a clear distinction between primary and secondary ingredients: Rehmannia glutinosa is the core principal ingredient (with the highest dosage) to ensure the fundamental direction of "tonifying the kidney and generating essence"; Lycium barbarum, Angelica sinensis, and Cornus officinalis are the assistant ingredients (with the second highest dosage) to strengthen the core effects of "nourishing blood, strengthening the kidney, and improving eyesight"; the remaining medicinal materials are adjuvants and guides to take into account "soothing the liver, calming the mind, and promoting skin penetration", forming a complete closed loop of "tonifying the root, clearing the channels, eliminating interference, and promoting absorption".

[0057] Complementary effects: Blood-tonifying herbs (Rehmannia glutinosa and Angelica sinensis) are combined with essence-tonifying herbs (Lycium barbarum and Cornus officinalis) to address the issue of "blood and essence sharing the same origin"; Liver-soothing herbs (Bupleurum chinense) are combined with tranquilizing herbs (Albizia julibrissin) to eliminate the cause of "emotional damage to the eyes"; Local vision-improving herbs (Chrysanthemum and Tribulus terrestris) are combined with systemic conditioning herbs (Rehmannia glutinosa and Dendrobium nobile) to achieve dual protection of "local + overall". Ultimately, through precise proportions, the effects of each herb are superimposed, far exceeding the eye-protecting effects of a single herb, effectively relieving problems such as dryness, fatigue, and decreased vision from the root.

[0058] This application utilizes the synergistic effect of traditional Chinese medicine extracts and penetration enhancers to not only improve the body's absorption of traditional Chinese medicine extracts, but also to ensure that the traditional Chinese medicine eye patch meets the requirements of being non-irritating to the skin, having a suitable penetration enhancement efficiency, and being suitable for sensitive skin around the eyes.

[0059] This application utilizes the synergistic effect of traditional Chinese medicine extracts and carrier matrix to achieve advantages such as good adhesion to the eyes, no allergenicity, and greater stability during use of traditional Chinese medicine eye patches.

[0060] In a preferred embodiment, the penetration enhancer comprises the following raw materials by weight: 2-3 parts menthol, 0.5-1 parts azone, and 1-2 parts chitosan.

[0061] Furthermore, the penetration enhancer, with its core functions of "cooling and soothing + high-efficiency transdermal absorption + bioadhesion", can open the "absorption channels" of the skin around the eyes, increasing the transdermal absorption rate of Chinese herbal extracts from the traditional <3% to over 10%-15%.

[0062] Menthol 2-3 parts: cooling and promotes penetration, soothes nerves; Azone 0.5-1 part: highly effective transdermal penetration enhancer; Chitosan 1-2 parts: bioadhesive penetration enhancer.

[0063] In a preferred embodiment, the penetration enhancer may further include the following raw materials by weight: 2-3.5 parts menthol lactate, 1.5-2.5 parts eucalyptus oil, 0.5-1.2 parts lauryl acetone, 3-5 parts propylene glycol, 1-1.8 parts sodium hyaluronate, and 0.8-1.5 parts xanthan gum.

[0064] Menthol lactate 2-3.5 parts: less irritating than menthol, avoids redness and stinging of the eye area; retains the cooling sensation while enhancing compatibility with other penetration enhancers and prolonging the soothing effect;

[0065] Eucalyptus oil 1.5-2.5 parts: Naturally sourced, highly safe, with both cooling and soothing properties and mild antibacterial effects; works synergistically with azone to enhance transdermal absorption, and has a mild, non-irritating scent.

[0066] Lauryl azone 0.5-1.2 parts: Transdermal efficiency is comparable to azone, but irritation to the delicate skin around the eyes is reduced by more than 30%; It is compatible with the fat-soluble components of traditional Chinese medicine extracts, promoting the transdermal absorption of active ingredients.

[0067] Propylene glycol 3-5 parts: A natural polyol that combines penetration enhancement and moisturizing functions, avoiding skin dryness caused by a single penetration enhancer; it works synergistically with chitosan to form a dual-effect layer of "penetration enhancement + moisturizing", improving user comfort.

[0068] Sodium hyaluronate 1-1.8 parts: Excellent biocompatibility, strong adhesion and can form a breathable film on the skin around the eyes; it has both moisturizing and penetration-promoting functions, reduces the irritation of Chinese herbal extracts to the skin, and prolongs the duration of drug efficacy.

[0069] Xanthan gum 0.8-1.5 parts: Naturally sourced, with stable adhesion, suitable for water-based matrices; works synergistically with glycerin and sodium alginate to enhance the overall stability of the matrix and prevent the penetration enhancer from separating.

[0070] The aforementioned penetration enhancers work synergistically in three dimensions: "cooling-penetration-adhesion". In the formula, the cooling ingredients (such as menthol / menthol lactate) first soothe the nerves in the eyes and relax the stratum corneum of the skin, opening up the absorption channels for the penetration enhancers (azone / lauryl azone); the adhesive ingredients (chitosan / sodium hyaluronate) fix the penetration enhancers and traditional Chinese medicine extracts on the surface of the skin around the eyes, preventing the loss of ingredients and increasing the transdermal efficiency by 40%-60%. It also matches the physiological rhythm of "the kidney meridian is dominant at the hour of You" to ensure that the efficacy of the medicine continues to work during the key period of nourishing kidney essence.

[0071] The above-mentioned penetration enhancers have strong safety compatibility: all formula ingredients have passed the eye skin irritation test (no redness, swelling, or stinging reaction), which meets the requirements of the "Cosmetic Safety Technical Specifications" for raw materials used in the eye area, solves the pain point of traditional penetration enhancers being "highly effective but irritating", and is suitable for long-term wear needs.

[0072] In a preferred embodiment, the carrier matrix comprises the following raw materials by weight: 15-20 parts gelatin, 2-4 parts sodium alginate, 5-8 parts glycerin, 1-2 parts polyvinylpyrrolidone, and an appropriate amount of purified water.

[0073] The carrier matrix in this application has "gel forming + moisturizing and bonding" as its core function, which enables the Chinese herbal eye patch to have good adhesion to the eye and meet the requirements of non-allergenicity, while also being compatible with the solubility of penetration enhancers and Chinese herbal extracts.

[0074] 15-20 parts gelatin: gel matrix; 2-4 parts sodium alginate: moisturizing and thickening agent; 5-8 parts glycerin: humectant; 1-2 parts polyvinylpyrrolidone: binder; appropriate amount of purified water: solvent.

[0075] In a preferred embodiment, the carrier matrix comprises the following raw materials by weight: 12-18 parts carrageenan, 10-15 parts hydroxypropyl methylcellulose, 2-3.5 parts pectin, 1.5-3 parts gum arabic, 4-7 parts 1,3-propanediol, 3-6 parts panthenol, 1-1.8 parts povidone K30, 0.8-1.5 parts guar gum, and an appropriate amount of purified water.

[0076] Carrageenan 12-18 parts: The gel strength is comparable to gelatin, but the salt resistance is stronger, making it suitable for mineral components in traditional Chinese medicine extracts; it contains no animal-derived ingredients (gelatin comes from animals), avoiding the risk of allergies, and is suitable for vegetarians;

[0077] Hydroxypropyl methylcellulose 10-15 parts: good water solubility, high gel transparency, does not affect the appearance of the eye mask; excellent compatibility with penetration enhancers, can extend the shelf life of the gel to 18 months;

[0078] 2-3.5 parts pectin: Natural plant source, with better moisturizing properties than sodium alginate, and can form a stable gel with calcium ions; synergistically with glycerin, it enhances the water-locking ability of the matrix and prevents dry skin around the eyes.

[0079] 1.5-3 parts gum arabic: It has a gentle thickening effect, making the gel texture more delicate and conforming to the contours of the eyes; it also has a certain degree of adhesion, which can reduce the amount of polyvinylpyrrolidone used and reduce the risk of allergies.

[0080] 1,3-Propanediol 4-7 parts: Naturally fermented, with moisturizing properties comparable to glycerin, but with a lighter, non-sticky feel; works synergistically with sodium hyaluronate (a penetration enhancer replacement ingredient) to form a "double moisturizing network," suitable for use in dry environments.

[0081] Panthenol 3-6 parts: It has both moisturizing and repairing functions and can repair the damaged stratum corneum around the eyes; it works synergistically with the "blood-nourishing components" (such as angelica) in traditional Chinese medicine extracts to enhance the skin's absorption and tolerance to the efficacy of the medicine.

[0082] 1-2 parts of polyvinylpyrrolidone:

[0083] Guar gum 0.8-1.5 parts: a natural modified polysaccharide that combines adhesiveness and safety; synergistically with xanthan gum (a chitosan substitute) to enhance the matrix's anti-settling properties and prevent the separation of traditional Chinese medicine extracts.

[0084] The above-mentioned carrier matrix is ​​"optimized for compatibility": the replaced matrix materials (such as HPMC and pectin) are all "water-soluble and low-allergenic" and can simultaneously dissolve the water-soluble (such as angelica polysaccharide) and fat-soluble (such as chrysanthemum flavonoids) components of traditional Chinese medicine extracts, solving the problem of "poor component solubility and easy stratification" of traditional matrix.

[0085] The above-mentioned carrier matrix is ​​"suitable for the time of day": the consistency and adhesion of the matrix gel have been optimized (e.g., the elastic modulus of the carrageenan matrix is ​​200-300Pa) to adapt to eye movements during sleep at night (such as turning over), to prevent the gel from falling off, and to ensure that the efficacy of the drug continues to work from the time of day (17:00-19:00) into the night.

[0086] The aforementioned carrier matrix features "upgraded safety": all replacement components are food-grade or cosmetic-grade raw materials, have passed acute dermal toxicity tests (LD50 > 5000 mg / kg), and contain no heavy metals or preservative residues, making them suitable for long-term wear.

[0087] A second aspect of the present invention provides a method for preparing the aforementioned traditional Chinese medicine eye patch, characterized by comprising the following steps:

[0088] S1. Preparation of Chinese herbal medicine mixture: After mixing and stirring the Chinese herbal medicine extract with the penetration enhancer evenly, a Chinese herbal medicine mixture is obtained and set aside for later use;

[0089] S2. Preparation of β-cyclodextrin inclusion complex: Add the traditional Chinese medicine mixture from step S1 to β-cyclodextrin, mix and stir evenly, and finally solidify by refrigeration to obtain β-cyclodextrin inclusion complex for later use;

[0090] S3. Preparation of nanoliposome mixture: The β-cyclodextrin inclusion complex from step S2 is added to the homogenized lipid membrane and mixed evenly. Finally, the mixture is obtained by ultrasonic treatment and set aside for later use.

[0091] S4. Preparation of carrier matrix: Take the carrier matrix material and prepare it into a carrier matrix for later use;

[0092] S5. Preparation of Traditional Chinese Medicine Eye Patches: Slowly add the nanoliposome mixture from step S3 to the carrier matrix from step S4, stir evenly, and homogenize to obtain the traditional Chinese medicine eye patches (e.g., ...). Figure 3 (As shown).

[0093] Furthermore, in step S1, a targeted extraction process is designed for the three medicinal herbs chrysanthemum, tribulus terrestris, and dendrobium, taking into account their effective ingredient characteristics and the eye mask's efficacy requirements of "nourishing yin and improving eyesight, calming the liver and relieving depression." This ensures the efficient enrichment of key active ingredients and works in synergy with other medicinal herb extraction processes to maximize the overall eye care efficacy.

[0094] Specifically, chrysanthemum is extracted using a combined ultrasonic and microwave extraction process to precisely extract flavonoids (such as luteolin and apigenin) and chlorogenic acid components (which are crucial for relieving eye strain and improving visual fatigue) that have the effects of "soothing the liver and improving eyesight"; the microwave power is 300W, the ultrasonic frequency is 40kHz, the extraction temperature is 55℃, the extraction time is 40min, and the liquid-to-solid ratio is 15:1 (mL / g); this ensures the activity of the extract components and is suitable for gentle eye care needs.

[0095] Tribulus terrestris was extracted using a two-phase solvent extraction process to specifically extract tribulus saponins and halmanine, which have the effects of "soothing the liver and relieving depression, improving eyesight and relieving dizziness" (these components can improve eye accommodation function and relieve visual dizziness). The process involved first defatting by reflux (petroleum ether, 60℃, 2h), followed by ultrasonic-assisted ethanol extraction (temperature 60℃, frequency 35kHz, time 50min, liquid-to-solid ratio 20:1), and finally concentration under reduced pressure (vacuum degree 0.08MPa, temperature 50℃). Ultrasonic-assisted extraction shortened the extraction time, avoided high temperature damage to the activity of alkaloid components, and ensured the stability of the "soothing the liver and improving eyesight" efficacy.

[0096] Dendrobium is extracted using an enzymatic hydrolysis and ultrasound-assisted water extraction process to efficiently extract Dendrobium polysaccharides (the core active ingredient) and bibenzyl compounds (which can enhance eye adaptability and improve dry eyes) that have the effects of "nourishing yin and improving eyesight" and "nourishing liver and protecting eyes". The enzymatic hydrolysis is followed by ultrasound-assisted water extraction at an ultrasound frequency of 38kHz, an extraction temperature of 60℃, an extraction time of 55min, and a liquid-to-solid ratio of 25:1 (mL / g). The filtrates are combined after two extractions and concentrated under reduced pressure. The water extraction system is safe and gentle, with no organic solvent residue, and is suitable for contact use with the eyes and skin. In addition, the polysaccharide component can synergistically enhance the "nourishing yin and improving eyesight" effect with other blood-tonifying and kidney-tonifying components.

[0097] The extraction process of chrysanthemum and tribulus focuses on "soothing the liver and improving eyesight, and protecting the eyes locally", which works synergistically with the "soothing the liver and relieving depression" components of bupleurum and albizia bark to take into account both emotional regulation and relief of eye discomfort;

[0098] The extraction process of Dendrobium's "yin-nourishing polysaccharides" forms a "kidney-liver-eye" nourishing closed loop with the "kidney-tonifying components" of Rehmannia glutinosa and Cornus officinalis, and the "blood-tonifying components" of Angelica sinensis and Lycium barbarum. This fundamentally improves the physiological environment of the eyes and ensures that the key components of each medicinal material are efficiently enriched and have complementary effects.

[0099] In a preferred embodiment, step S2 includes the following sub-steps:

[0100] S21. Preparation of saturated aqueous solution of β-cyclodextrin: Add β-cyclodextrin to deionized water, stir to dissolve, and form an aqueous solution of β-cyclodextrin with a mass concentration of 8-12%;

[0101] S22. Inclusion reaction: The traditional Chinese medicine mixture from step S1 is slowly added dropwise to the β-cyclodextrin aqueous solution while stirring. After the addition is complete, the mixture is stirred at a constant temperature for 2-3 hours to obtain the inclusion solution.

[0102] S23. Cold storage and solidification: Place the inclusion solution from step S22 in a refrigerator for 12-24 hours to allow the inclusion compound to crystallize and precipitate.

[0103] S24. Separation and drying: First, the inclusion complex precipitate is separated by vacuum filtration or centrifugation. Then, it is washed with anhydrous ethanol to remove the unincluded volatile components. Finally, it is dried in a vacuum drying oven for 1-3 hours to obtain the β-cyclodextrin inclusion complex.

[0104] In a preferred embodiment, the mass ratio between the β-cyclodextrin inclusion complex and the homogeneous lipid membrane in step S3 is 1:1 to 3:1.

[0105] In a preferred embodiment, step S3 includes the following sub-steps:

[0106] S31. Raw Material Pretreatment: Soybean lecithin (65%-70%), cholesterol (10%-15%), and phosphatidylcholine (8%-12%) are dried in a 40℃ vacuum drying oven for 2 hours to remove moisture (to avoid air bubbles affecting particle size uniformity during preparation). Tween-80 (3%-5%) and glycerol (2%-4%) are filtered through a 0.22μm microporous membrane. Deionized water is boiled and then cooled to room temperature (to reduce microbial contamination). All raw materials are accurately weighed according to the formula ratio and set aside.

[0107] S32: Oil phase preparation: Add dried soybean lecithin, cholesterol, and phosphatidylcholine to a round-bottom flask, add an appropriate amount of anhydrous ethanol (2-3 times the volume of the oil phase), and stir in a 50°C constant temperature water bath until completely dissolved to form a transparent oil phase.

[0108] S33: Aqueous phase preparation: Add Tween-80 and glycerol to deionized water, stir until dissolved, then add β-cyclodextrin inclusion complex powder, and ultrasonically disperse for 5 minutes (power 300W) to form a homogeneous aqueous phase.

[0109] S34: Thin film formation: Transfer the oil phase to a rotary evaporator, set the temperature to 50℃ and the rotation speed to 80r / min, and evaporate under reduced pressure (vacuum degree 0.08-0.1MPa) until a uniform, crack-free lipid film is formed on the inner wall of the flask (30 minutes).

[0110] S35: Hydration and Ultrasonic Nanoparticle Sizing: Add all the aqueous phase to the flask containing the lipid film, stir in a 50°C constant temperature water bath for 30 minutes (200 r / min) to make the film completely swell and form a crude liposome suspension; transfer the crude suspension to an ultrasonic disruptor and sonicate under ice bath conditions for 10-15 minutes (400W power, 3 seconds working / 2 seconds intermittent) to control the particle size at 80-100 nm (monitored in real time by a dynamic light scattering instrument).

[0111] Soybean lecithin accounts for 65%-70% of the main membrane material, providing a lipid bilayer structure that encapsulates the lipid-soluble (such as flavonoids and saponins) and water-soluble (such as polysaccharides) components of traditional Chinese medicine. It has excellent biocompatibility and can be quickly absorbed by the skin.

[0112] Cholesterol 10%-15% regulates the fluidity of the lipid bilayer, enhances membrane structural stability, prevents nanoparticles from breaking during storage or use, and ensures that the core components are not lost.

[0113] Phosphatidylcholine 8%-12% is used as an auxiliary membrane material to enhance the affinity of liposomes for the stratum corneum of the skin, adapting to the physiological characteristics of slightly open skin pores at dusk and accelerating penetration.

[0114] Tween-80 3%-5% is a nonionic emulsifier that reduces the interfacial tension between liposomes and the drug solution, thereby improving the encapsulation efficiency of traditional Chinese medicine components (encapsulation rate can reach 82%-88%).

[0115] Glycerin 2%-4% is a moisturizing stabilizer that prevents liposomes from drying and agglomerating, while also working synergistically with moisturizing ingredients in the matrix to improve user comfort.

[0116] Add deionized water to bring the solvent to 100% to construct the liposome dispersion system and ensure uniform distribution of the particles.

[0117] In a preferred embodiment, step S4 includes the following sub-steps:

[0118] S41. Pretreatment: Soak gelatin in deionized water for 20-40 minutes to allow it to fully swell; disperse sodium alginate in deionized water, stir until there are no particles, and let it stand to remove bubbles;

[0119] S42. Heating to dissolve: Place the swollen gelatin from step S41 in a constant temperature water bath, stir until completely dissolved, add glycerin, and continue stirring for 8-12 minutes to form a gelatin-glycerin solution;

[0120] S43. Composite thickening: Slowly add the sodium alginate dispersion from step S41 to the gelatin-glycerol solution from step S42, heat and stir to make the system uniformly mixed and form a preliminary gel system;

[0121] S44. Adhesion and reinforcement: Add polyvinylpyrrolidone in step S43 and stir for 15-25 minutes to ensure that the adhesive is completely dispersed and to avoid the formation of particles;

[0122] S45. Thickening and Volume Adjustment: Add the remaining deionized water to step S44, stir, and adjust the gel consistency to 8000-10000 mPa·s to obtain the carrier matrix. Keep it at 40-50℃ for later use.

[0123] Step S5 includes the following sub-steps:

[0124] S51. Initial mixing: Slowly add the preheated nanoliposome mixture to the insulated carrier matrix gel, and stir at low speed for 15 minutes (200 r / min) with a paddle stirrer to form an initial mixture;

[0125] S52. Homogenization: The preliminary mixture is transferred to a high-pressure homogenizer and homogenized three times for 5 minutes each time at a pressure of 20 MPa and a speed of 8000 r / min to ensure that the drug solution and matrix are completely integrated and the particle size distribution of the system is uniform (D90 < 5 μm).

[0126] S53. Degassing: After homogenization, transfer to a vacuum degassing machine and degas for 10 minutes at a vacuum of 0.09 MPa and 45°C to remove air bubbles from the mixture and prevent pores from forming during coating.

[0127] S54. Coating and molding: After vacuum degassing, the coating is applied to a non-woven fabric substrate and then cooled and molded.

[0128] S55. Cutting: After cooling and shaping, cut into traditional Chinese medicine eye patches that conform to the contours of the eye area.

[0129] In a third aspect of the present invention, the application of the traditional Chinese medicine eye patch in eye masks and eye films is described.

[0130] Optionally, the herbal eye patch is used during the evening (twilight period) to nourish the liver and kidneys, replenish liver blood, relieve eye fatigue, and prevent myopia.

[0131] Example 1

[0132] Embodiment 1 of the present invention provides a traditional Chinese medicine eye patch comprising: a traditional Chinese medicine extract, a penetration enhancer, and a carrier matrix; the formula of the traditional Chinese medicine eye patch by weight is shown in Table 1.

[0133] Table 1

[0134] This embodiment describes a method for preparing a traditional Chinese medicine eye patch, comprising the following steps:

[0135] S1. Preparation of Chinese herbal medicine mixture: After mixing and stirring the Chinese herbal medicine extract with the penetration enhancer evenly, a Chinese herbal medicine mixture is obtained and set aside for later use;

[0136] S2. Preparation of β-cyclodextrin inclusion complex: Add the traditional Chinese medicine mixture from step S1 to β-cyclodextrin, mix and stir evenly, and finally solidify by refrigeration to obtain β-cyclodextrin inclusion complex for later use;

[0137] S3. Preparation of nanoliposome mixture: The β-cyclodextrin inclusion complex from step S2 is added to the homogenized lipid membrane and mixed evenly. Finally, the mixture is obtained by ultrasonic treatment and set aside for later use.

[0138] S4. Preparation of carrier matrix: Take the carrier matrix material and prepare it into a carrier matrix for later use;

[0139] S5. Preparation of traditional Chinese medicine eye patch: Take the nanoliposome mixture from step S3 and slowly add it to the carrier matrix from step S4. After stirring evenly, homogenize to obtain the traditional Chinese medicine eye patch.

[0140] Example 2

[0141] Embodiment 2 of the present invention provides a traditional Chinese medicine eye patch comprising: a traditional Chinese medicine extract, a penetration enhancer, and a carrier matrix; the formula of the traditional Chinese medicine eye patch by weight is shown in Table 2.

[0142] Table 2

[0143] The preparation method in this embodiment is the same as that in Example 1.

[0144] Example 3

[0145] Embodiment 3 of the present invention provides a traditional Chinese medicine eye patch comprising: a traditional Chinese medicine extract, a penetration enhancer, and a carrier matrix; the formula of the traditional Chinese medicine eye patch by weight is shown in Table 3.

[0146] Table 3

[0147] The preparation method in this embodiment is the same as that in Example 1.

[0148] Example 4

[0149] Embodiment 4 of the present invention provides a traditional Chinese medicine eye patch comprising: a traditional Chinese medicine extract, a penetration enhancer, and a carrier matrix; the formula of the traditional Chinese medicine eye patch by weight is shown in Table 3.

[0150] Table 4

[0151] The preparation method in this embodiment is the same as that in Example 1.

[0152] Comparative Example 1

[0153] Comparative Example 1 of this invention provides a traditional Chinese medicine eye patch comprising: a traditional Chinese medicine extract, a penetration enhancer, and a carrier matrix; the formula of the traditional Chinese medicine eye patch, by weight, is shown in Table 5.

[0154] Table 5

[0155] The preparation method in this embodiment is the same as that in Example 1.

[0156] Comparative Example 2

[0157] Comparative Example 2 of this invention provides a traditional Chinese medicine eye patch comprising: a traditional Chinese medicine extract, a penetration enhancer, and a carrier matrix; the formula of the traditional Chinese medicine eye patch, by weight, is shown in Table 6.

[0158] Table 6

[0159] The preparation method in this embodiment is the same as that in Example 1.

[0160] Comparative Example 3

[0161] Comparative Example 3 of this invention provides a traditional Chinese medicine eye patch comprising: a traditional Chinese medicine extract, a penetration enhancer, and a carrier matrix; the formula of the traditional Chinese medicine eye patch, by weight, is shown in Table 7.

[0162] Table 7

[0163] The preparation method in this embodiment is the same as that in Example 1.

[0164] Comparative Example 4

[0165] Comparative Example 1 of this invention provides a traditional Chinese medicine eye patch comprising: a traditional Chinese medicine extract and a penetration enhancer; the formula of the traditional Chinese medicine eye patch, by weight, is shown in Table 8.

[0166] Table 8

[0167] The preparation method in this embodiment is the same as that in Example 1, except that step S4 is omitted.

[0168] Comparative Example 5

[0169] Comparative Example 1 of this invention provides a traditional Chinese medicine eye patch comprising: a traditional Chinese medicine extract, a penetration enhancer, and a carrier matrix; the formula of the traditional Chinese medicine eye patch, by weight, is shown in Table 9.

[0170] Table 9

[0171] The preparation method in this embodiment is the same as that in Example 1.

[0172] Comparative Example 6

[0173] Comparative Example 6 of this invention provides a traditional Chinese medicine eye patch comprising: by weight, the formula of the traditional Chinese medicine eye patch is shown in Table 10.

[0174] Table 10

[0175] The preparation method in this embodiment is the same as that in Example 1, except that steps S1-S3 are omitted.

[0176] Comparative Example 7

[0177] Comparative Example 6 of this invention provides a traditional Chinese medicine eye patch that is identical to Example 1, except that the preparation process does not include the following step:

[0178] S2. Preparation of β-cyclodextrin inclusion complex: Add the traditional Chinese medicine mixture from step S1 to β-cyclodextrin, mix and stir evenly, and finally solidify by refrigeration to obtain β-cyclodextrin inclusion complex for later use;

[0179] S3. Preparation of nanoliposome mixture: The β-cyclodextrin inclusion complex from step S2 is added to the homogenized lipid membrane and mixed evenly. Finally, the mixture is obtained by ultrasonic treatment and set aside for later use.

[0180] Experimental Example 1:

[0181] Experimental subjects: a mixture of nanoliposomes prepared in any one of Examples 1-4;

[0182] Experimental equipment: Transmission electron microscope (TEM, model: JEM-2100), scanning electron microscope (SEM, model: SU8010).

[0183] Experimental method: 1. Take 10 μL of nanoliposome suspension and drop it onto a copper mesh support membrane, and let it stand at room temperature for 2 min;

[0184] 2. Blot away excess liquid with filter paper, add 2% phosphotungstic acid solution (pH=7.0) and stain for 1 minute, then allow to air dry.

[0185] 3. Place the sample on the electron microscope stage, adjust the accelerating voltage to 100kV (TEM) and 5kV (SEM), and observe and take pictures.

[0186] Experimental conclusion:

[0187] like Figure 1The transmission electron microscope results show that spherical or near-spherical particles with a particle size distribution of 80-100 nm can be clearly observed. The surface of the particles is smooth, and the internal structure of alternating light and dark lipid bilayers is visible, proving that the liposomes are fully formed. At the same time, it can be observed that the traditional Chinese medicine components (such as polysaccharides and flavonoids) are encapsulated inside the liposomes or embedded on the membrane, presenting a "core-shell" structure, proving that the encapsulation is successful.

[0188] like Figure 1 The scanning electron microscope (SEM) results show that the nanoliposomes are uniformly distributed on the surface of the nonwoven fabric substrate without obvious aggregation. The particle size is consistent with the TEM characterization, which proves that the liposomes are well dispersed in the matrix, laying the foundation for transdermal absorption.

[0189] Experimental Example 2:

[0190] Experimental subjects: 60 volunteers (aged 25-45 years, all meeting the symptoms of "dry eyes, blurred vision, and worsening eye fatigue in the evening") who had long-term use of electronic devices and suffered from eye fatigue, were randomly divided into 3 groups of 20 people each.

[0191] Experimental method: All three groups wore eye patches for 30 minutes each time from 17:00 to 18:00 (the hour of the Rooster) for 28 consecutive days.

[0192] Experimental testing standards and testing time points:

[0193] 1. Eye fatigue relief rate: The Subjective Evaluation Scale for Visual Fatigue (0-10 points, the higher the score, the more severe the fatigue) was used. Scores were recorded before use, 14 days after use, and 28 days after use. The relief rate was calculated (Relief rate = (Score before use - Score after use) / Score before use × 100%).

[0194] 2. Tear secretion: The Schirmer I test (filter paper strip method) was used to measure tear secretion (mm / 5min) before use and 28 days after use.

[0195] 3. Serum indicators related to kidney essence: The levels of "adrenocorticotropic hormone (ACTH)" and "cortisol (CORT)" in serum were measured before use and 28 days after use (the kidney meridian is active during the You hour and is related to endocrine function; ACTH and CORT levels can indirectly reflect the fullness of kidney essence).

[0196] The experimental results are shown in the table below:

[0197] Experimental conclusion:

[0198] Conclusion 1: Based on the results of Examples 1-4 and Comparative Examples 1-7, we can conclude that:

[0199] The herbal eye patch in this application has a more significant eye care effect: After use at 5 PM by combining the herbal formula and preparing it with special technology, the eye fatigue relief rate and tear secretion volume are significantly higher than those of the comparative sample, proving that the combination of "tonifying the kidney and replenishing essence + nourishing blood and soothing the liver" and the synergistic effect of the medicine can effectively improve problems such as dry eyes and fatigue.

[0200] Conclusion 2: Based on the results of Examples 1-4 and Comparative Examples 1-7, we can conclude that:

[0201] The compatibility of the herbal eye patch in this application with the theory of the You hour (5-7 PM): The serum ACTH and CORT levels in the formulation group of this invention were significantly higher than those in the control group, indicating that the formulation can effectively improve kidney essence-related endocrine indicators during the You hour when the kidney meridian is dominant. This verifies the scientific nature of the theory of "midnight-noon flow - kidney meridian dominance during the You hour" in the formulation design. That is, by matching the high proportion of the principal herb (Rehmannia glutinosa) with the physiological rhythm of the You hour, the effects of "tonifying the kidney → generating blood → nourishing the eyes" can be achieved.

[0202] Conclusion 3: Based on the conclusions of Examples 1 and 2, we can conclude that:

[0203] The difference between Example 1 and Example 2 lies in the raw materials of the penetration enhancer and the carrier matrix. According to the experimental data, the optimal choice of penetration enhancer is: "3.5 parts menthol lactate, 2.5 parts eucalyptus oil, 1.2 parts lauryl acetone, 5 parts propylene glycol, 1.8 parts sodium hyaluronate, and 1.5 parts xanthan gum". The optimal choice of carrier matrix is: "18 parts carrageenan, 15 parts hydroxypropyl methylcellulose, 3.5 parts pectin, 3 parts gum arabic, 7 parts 1,3-propanediol, 6 parts panthenol, 1.8 parts povidone K30, 1.5 parts guar gum, and an appropriate amount of purified water".

[0204] Conclusion 4: Based on the conclusions of Examples 2 and 3-4, we can conclude that:

[0205] The difference between Example 2 and Examples 3-4 is that the weight fractions of the Chinese herbal extracts are different. According to the experimental data, the optimal ratio of the Chinese herbal extracts is: "20 parts Rehmannia glutinosa, 16 parts Lycium barbarum, 12 parts Angelica sinensis, 8 parts Bupleurum chinense, 10 parts Chrysanthemum morifolium, 8 parts Tribulus terrestris, 12 parts Dendrobium nobile, 14 parts Cornus officinalis, 6 parts Albizia julibrissin, and 1.5 parts Borneol".

[0206] Conclusion 5: Based on the conclusions of Example 2 and Comparative Example 1, we can conclude that:

[0207] The difference between Example 2 and Comparative Example 1 is that the core components "Rehmannia glutinosa and Cornus officinalis" are missing from the Chinese herbal extract. According to the experimental data, 1. the eye fatigue relief rate decreased by about 50%, 2. the tear secretion volume decreased by about 50%, and 3. the serum indicators related to kidney essence decreased by about 40%. It can be seen that by combining Rehmannia glutinosa (a blood-tonifying herb) and Cornus officinalis (a essence-tonifying herb), the problem of "blood and essence sharing the same origin" can be solved, thus fundamentally relieving the problem of eye fatigue.

[0208] Conclusion 6: Based on the conclusions of Example 2 and Comparative Example 2, we can conclude that:

[0209] The difference between Example 2 and Comparative Example 2 is that the herbal extract lacks the components "chrysanthemum and tribulus terrestris". According to the experimental data, 1. the eye fatigue relief rate decreased by approximately 40%, 2. tear secretion decreased by approximately 40%, and 3. kidney essence-related serum indicators decreased by approximately 30%. This indicates that chrysanthemum and tribulus terrestris can effectively regulate local eye function. Chrysanthemum "soothes the liver and brightens the eyes, clears the head and eyes," directly addressing the stimulation of the eyes caused by changes in light (such as reduced light at dusk and blue light from electronic screens). Tribulus terrestris "soothes the liver and relieves depression, brightens the eyes and stops dizziness," improving the regulatory function of eye muscles and relieving soreness and dizziness after prolonged eye use. The two work synergistically to "soothe the liver and brighten the eyes," addressing both emotional and local eye discomfort.

[0210] Conclusion 7: Based on the conclusions of Example 2 and Comparative Example 3, we can conclude that:

[0211] The difference between Example 2 and Comparative Example 3 is that 20 parts of Rehmannia glutinosa were replaced with 20 parts of chrysanthemum in the herbal extract; that is, Rehmannia glutinosa was removed and the same amount of chrysanthemum was added. According to the experimental data, 1. the eye fatigue relief rate decreased by about 40%, 2. the tear secretion decreased by about 40%, and 3. the serum indicators related to kidney essence decreased by about 30%. It can be seen that Rehmannia glutinosa, as the principal herb, lays the foundation for "nourishing yin and replenishing blood, benefiting essence and filling marrow". It indirectly provides a source for liver blood by replenishing kidney essence (the kidney stores essence, and essence can generate blood). Especially in response to the physiological law of "kidney meridian is in charge at You time", its use at this time can maximize the nourishing efficiency of kidney essence and fundamentally provide "energy reserves" for the eyes. Its components and ratios are irreplaceable.

[0212] Conclusion 8: Based on Example 2 and Comparative Example 4, it can be concluded that:

[0213] The difference between Example 2 and Comparative Example 4 is that the herbal eye patch in Comparative Example 3 does not contain a carrier matrix. According to the experimental data, the eye fatigue relief rate, sperm-related serum indicators, and tear secretion volume decreased significantly, indicating that the carrier matrix can effectively provide a carrier for the herbal extract.

[0214] Conclusion 9: As can be seen from Example 2 and Comparative Example 5:

[0215] The difference between Example 2 and Comparative Example 5 is that the herbal eye patch in Comparative Example 3 does not contain a penetration enhancer. According to the experimental data, the eye fatigue relief rate, sperm-related serum indicators, and tear secretion volume decreased significantly, indicating that the carrier matrix can effectively provide permeability for the herbal extract, facilitating human absorption.

[0216] Conclusion 10: As can be seen from Example 2 and Comparative Example 6:

[0217] The difference between Example 2 and Comparative Example 6 is that the herbal eye patch in Comparative Example 3 does not contain herbal extracts. According to experimental data, the eye fatigue relief rate, serum-related indicators, and tear secretion decreased by approximately 90%. This indicates that the herbal eye patch of this technology, based on the traditional Chinese medicine theory of "liver blood nourishing the eyes and kidney essence nourishing the eyes," achieves a synergistic effect through precise formulation of 10 herbal ingredients. This fundamentally improves the physiological environment of the eyes while also considering the impact of emotions on vision, ultimately achieving a dual eye-protecting effect of "nourishing the root and protecting the surface."

[0218] Conclusion 11: Based on Example 2 and Comparative Example 7, it can be concluded that:

[0219] The difference between Example 2 and Comparative Example 7 is that Comparative Example 7 does not contain the preparation processes of S2. preparing β-cyclodextrin inclusion complex and S3. preparing nanoliposome mixture. According to the experimental data, the eye fatigue relief rate, serum related indicators, and tear secretion decreased slightly. It can be seen that the traditional Chinese medicine eye patch prepared by the above process can lay the foundation for transdermal absorption and is more convenient for human absorption.

Claims

1. A traditional Chinese medicine eye patch, characterized in that, The herbal eye patch comprises: herbal extract, penetration enhancer and carrier matrix; the herbal extract comprises the following raw materials by weight: 15-25 parts of Rehmannia glutinosa, 12-20 parts of Lycium barbarum, 10-18 parts of Cornus officinalis, 8-15 parts of Dendrobium nobile, 10-15 parts of Angelica sinensis, 5-10 parts of Bupleurum chinense, 8-12 parts of Chrysanthemum morifolium, 6-10 parts of Tribulus terrestris, 5-8 parts of Albizia julibrissin bark, and 1-2 parts of Borneol.

2. The herbal eye patch according to claim 1, characterized in that, The penetration enhancer comprises the following raw materials by weight: 2-3 parts menthol, 0.5-1 parts azone, and 1-2 parts chitosan.

3. The herbal eye patch according to claim 1, characterized in that, The penetration enhancer comprises the following raw materials in parts by weight: 2-3.5 parts menthol lactate, 1.5-2.5 parts eucalyptus oil, 0.5-1.2 parts lauryl acetone, 3-5 parts propylene glycol, 1-1.8 parts sodium hyaluronate, and 0.8-1.5 parts xanthan gum.

4. The herbal eye patch according to claim 1, characterized in that, The carrier matrix comprises the following raw materials by weight: 15-20 parts gelatin, 2-4 parts sodium alginate, and 5-8 parts glycerin. 1-2 parts of polyvinylpyrrolidone and an appropriate amount of purified water.

5. The herbal eye patch according to claim 1, characterized in that, The carrier matrix comprises the following raw materials by weight: 12-18 parts carrageenan, 10-15 parts hydroxypropyl methylcellulose, 2-3.5 parts pectin, 1.5-3 parts gum arabic, 4-7 parts 1,3-propanediol, 3-6 parts panthenol, 1-1.8 parts povidone K30, 0.8-1.5 parts guar gum, and an appropriate amount of purified water.

6. A method for preparing a traditional Chinese medicine eye patch according to any one of claims 1-5, characterized in that, Includes the following steps: S1. Preparation of Chinese herbal medicine mixture: After mixing and stirring the Chinese herbal medicine extract with the penetration enhancer evenly, a Chinese herbal medicine mixture is obtained and set aside for later use; S2. Preparation of β-cyclodextrin inclusion complex: Add the traditional Chinese medicine mixture from step S1 to β-cyclodextrin, mix and stir evenly, and finally solidify by cold storage to obtain β-cyclodextrin inclusion complex for later use; S3. Preparation of nanoliposome mixture: The β-cyclodextrin inclusion complex from step S2 is added to the homogenized lipid membrane and mixed evenly. Finally, the nanoliposome mixture is obtained by ultrasonic treatment and set aside for later use. S4. Preparation of carrier matrix: Take the carrier matrix material and prepare it into a carrier matrix for later use; S5. Preparation of traditional Chinese medicine eye patch: Take the nanoliposome mixture from step S3 and slowly add it to the carrier matrix from step S4. After stirring evenly, homogenize to obtain the traditional Chinese medicine eye patch.

7. The method for preparing the traditional Chinese medicine eye patch according to claim 6, characterized in that, Step S2 includes the following sub-steps: S21. Preparation of saturated aqueous solution of β-cyclodextrin: Add β-cyclodextrin to deionized water, stir to dissolve, and form an aqueous solution of β-cyclodextrin with a mass concentration of 8-12%; S22. Inclusion reaction: The traditional Chinese medicine mixture from step S1 is slowly added dropwise to the β-cyclodextrin aqueous solution while stirring. After the addition is complete, the mixture is stirred at a constant temperature for 2-3 hours to obtain the inclusion solution. S23. Cold refrigeration and solidification: Place the inclusion solution from step S22 in a refrigerator for 12-24 hours to allow the inclusion compound to crystallize and precipitate. S24. Separation and drying: First, the inclusion complex precipitate is separated by vacuum filtration or centrifugation. Then, it is washed with anhydrous ethanol to remove the unincluded volatile components. Finally, it is dried in a vacuum drying oven for 1-3 hours to obtain the β-cyclodextrin inclusion complex.

8. The method for preparing the traditional Chinese medicine eye patch according to claim 6, characterized in that, In step S3, the mass ratio between the β-cyclodextrin inclusion complex and the homogeneous lipid membrane is 1:1 to 3:

1.

9. The method for preparing the traditional Chinese medicine eye patch according to claim 6, characterized in that, Step S4 includes the following sub-steps: S41. Pretreatment: Soak gelatin in deionized water for 20-40 minutes to allow it to fully swell; disperse sodium alginate in deionized water, stir until there are no particles, and let it stand to remove bubbles; S42. Heating to dissolve: Place the swollen gelatin from step S41 in a constant temperature water bath, stir until completely dissolved, add glycerin, and continue stirring for 8-12 minutes to form a gelatin-glycerin solution; S43. Composite thickening: Slowly add the sodium alginate dispersion from step S41 to the gelatin-glycerol solution from step S42, heat and stir to mix the system evenly and form a preliminary gel system; S44. Adhesion and reinforcement: Add polyvinylpyrrolidone to step S43 and stir for 15-25 minutes to ensure that the adhesive is completely dispersed and to avoid the formation of particles; S45. Thickening and Volume Adjustment: Add the remaining deionized water to step S44, stir, and adjust the gel consistency to 8000-10000 mPa·s to obtain the carrier matrix. Keep it at 40-50℃ for later use.

10. The application of a traditional Chinese medicine eye patch according to any one of claims 1-8 and the traditional Chinese medicine eye patch prepared according to claim 9 in eye masks and eye films.

Images