Traditional Chinese medicine composition for treating headache and preparation method thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and provides a traditional Chinese medicine composition for treating headache and a preparation method thereof. According to the treatment principle, concha haliotidis and gastrodia elata have the effects of calming the liver, suppressing yang, dispelling wind and relieving pain, mother-of-pearl has the effects of calming the liver, suppressing yang, soothing the nerves and arresting convulsion, cape jasmine is bitter and cold in taste and can clear away heat of the heart, the lung and triple jiao, fried tribulus terrestris has the effects of calming the liver, relieving depression and promoting blood circulation to dispel wind, ligusticum wallichii and radix saposhnikoviae have the effects of dispelling wind and relieving pain, angelica sinensis has the effects of promoting blood circulation to remove blood stasis and dredging collaterals, cynanchum paniculatum has the effects of dispelling wind, resolving dampness and relieving pain, and pollen typhae has the effects of stopping bleeding and relieving pain. Radix angelicae has the effects of dispelling wind and relieving pain; animal experiments show that the traditional Chinese medicine composition obviously prolongs the appearance time of red ears, shortens the disappearance time of the red ears, obviously reduces the scratching frequency, can improve behavioral symptoms of rat migraine caused by nitroglycerin, plays a pharmacological role in treating the migraine, and provides a safe and efficient treatment scheme for the migraine.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine technology, and relates to a traditional Chinese medicine composition for treating headaches and its preparation method. Background Technology

[0002] Headache refers to pain localized to the upper part of the head, including the area above the line connecting the eyebrows, the upper edge of the auricle, and the external occipital protuberance. Headaches are one of the most common ailments, severely interfering with people's normal lives and reducing work and study efficiency. Headaches have a high incidence rate, are recurrent, and have a prolonged course. While Western medicine treatments for headaches are effective, they have significant side effects. Long-term use can easily lead to drug dependence and tolerance, causing drug abuse and negatively impacting the healthcare system.

[0003] During the Jin and Yuan dynasties, the *Dongheng Shishu* (Ten Books of Dongheng) categorized headaches into two types: exogenous and endogenous. Exogenous headaches are often caused by improper lifestyle habits, leading to exposure to external pathogens such as wind, cold, dampness, and heat, with wind being the most prevalent. The *Suwen* (Plain Questions) states, "Those injured by wind are first affected in the upper body." Wind is considered the chief of all diseases, easily combined with seasonal pathogens to cause illness. The head is the residence of clear yang; external invasion of the six pathogenic factors—wind, cold, dampness, and heat—obstructs clear yang, hinders the flow of qi and blood, and stagnates the sensory orifices, causing pain and headaches. Endogenous headaches are mostly caused by dysfunction of the internal organs. Both deficiency and excess patterns exist, and they can transform into each other under certain conditions. Endogenous headaches are closely related to pathological factors such as qi, blood, phlegm, blood stasis, and deficiency; they can cause illness independently or in combination with other pathogenic factors. As stated in "Zhengzhi Zhunsheng: Headache": "The head is like the sky, where the clear yang qi of the three yang and six fu organs all converge, and the essence blood of the three yin and five zang organs also flows into the head. Therefore, the six evils caused by the weather and the five thieves caused by the human qi can all cause harm."

[0004] Currently, some traditional Chinese medicine compound prescriptions have been applied in clinical treatment of this disease, but the efficacy is generally poor. Although they have some effect on headaches, the effect is still unstable. Summary of the Invention

[0005] In view of this, the present invention provides a traditional Chinese medicine composition for treating headaches and a method for preparing the same.

[0006] The present invention also provides a method for preparing the above-mentioned traditional Chinese medicine composition for treating headaches.

[0007] The present invention also provides the application of the above-mentioned traditional Chinese medicine composition for treating headaches in the preparation of headache remedies.

[0008] The technical solution adopted by the present invention to achieve the above objectives is as follows: In a first aspect, the present invention provides a traditional Chinese medicine composition for treating headaches, prepared from the following raw materials, by weight: 25-35 parts of abalone shell, 12-18 parts of stir-fried tribulus terrestris, 10-15 parts of charred gardenia, 12-18 parts of raw cattail pollen, 10-15 parts of angelica sinensis, 18-24 parts of chuanxiong rhizome, 10-15 parts of saposhnikovia root, 10-15 parts of angelica dahurica, 12-18 parts of cynanchum paniculatum, 25-35 parts of mother-of-pearl, 12-18 parts of gastrodia elata, and 4-8 parts of prepared licorice root.

[0009] In this invention, when a proportion, equivalent, temperature, concentration, time, mesh size, parts by weight, weight ratio, or other value or parameter is expressed as a range, a preferred range, or a range defined by a series of upper and lower preferred values, it should be understood as specifically disclosing all ranges formed by any pairing of any upper or preferred value with any lower or preferred value, regardless of whether the range is disclosed individually. For example, when the range "25-35" is disclosed, the described range should be interpreted as including the ranges "25-35", "25-34", "25-33", "25-32", "25-31", "25-30", "25-29", "25-28", "25-27", "25-26", "26-35", "26-34", "26-33", "26-32", "26-31", "26-30", "26-29", "26-28", "26-27", "27-35", "27-34", "27-33", "27-32", "27-31", and "27-30". "27-29", "27-28", "28-35", "28-34", "28-33", "28-32", "28-31", "28-30", "29-35", "29-34", "29-33", "29-32", "29-31", "29-30", "30-35", "30-34", "30-33", "30-32", "30-31", "31-35", "31-34", "31-33", "31-32", "32-35", "32-34", "32-33", "33-35", "33-34", "34-35", etc. When a numerical range is described herein, unless otherwise stated, the range is intended to include its endpoints and all integers and fractions within the range, and all numerical values ​​within the range are capable of achieving the effects of the present invention.

[0010] As a preferred technical solution of the present invention, the following components are contained in parts by weight: 30 parts of abalone shell, 15 parts of stir-fried tribulus terrestris, 12 parts of charred gardenia, 15 parts of raw cattail pollen, 12 parts of angelica sinensis, 21 parts of chuanxiong rhizome, 12 parts of saposhnikovia root, 12 parts of angelica dahurica root, 15 parts of cynanchum paniculatum, 30 parts of pearl powder, 15 parts of gastrodia elata, and 6 parts of prepared licorice root.

[0011] As a preferred technical solution of the present invention, the following components are contained in parts by weight: 25 parts of abalone shell, 12 parts of stir-fried tribulus terrestris, 10 parts of charred gardenia, 12 parts of raw cattail pollen, 10 parts of angelica sinensis, 18 parts of chuanxiong rhizome, 15 parts of saposhnikovia root, 10 parts of angelica dahurica, 12 parts of cynanchum paniculatum, 35 parts of pearl powder, 12 parts of gastrodia elata, and 4 parts of prepared licorice root.

[0012] As a preferred technical solution of the present invention, the following components are contained in parts by weight: 33 parts of abalone shell, 15 parts of stir-fried tribulus terrestris, 15 parts of charred gardenia, 18 parts of raw cattail pollen, 15 parts of angelica sinensis, 24 parts of chuanxiong rhizome, 15 parts of saposhnikovia root, 12 parts of angelica dahurica root, 18 parts of cynanchum paniculatum, 25 parts of pearl powder, 12 parts of gastrodia elata, and 6 parts of prepared licorice root.

[0013] In a second aspect, the present invention provides a method for preparing the above-mentioned traditional Chinese medicine composition for treating headaches, comprising the following steps: weighing each herb according to the proportion of raw materials, adding 6-8 times the amount of water, soaking for 30-60 minutes, reflux extraction for 50-60 minutes, and filtering out the liquid for later use; adding 6-8 times the amount of water to the residue again, reflux extraction for 25-35 minutes, filtering out the liquid, and combining it with the above-mentioned liquid to obtain the final product.

[0014] As a preferred technical solution of the present invention, the preparation method of the traditional Chinese medicine composition for treating headache includes the following steps: weigh each traditional Chinese medicine according to the proportion of raw materials, add 6 times the amount of water, soak for 60 minutes, reflux extract for 50 minutes, and filter out the medicinal liquid for later use; add 6 times the amount of water to the residue again, reflux extract for 25 minutes, filter out the medicinal liquid, and combine it with the above medicinal liquid to obtain the final product.

[0015] A third aspect of the present invention provides a traditional Chinese medicine preparation of a traditional Chinese medicine composition for treating headaches, characterized in that the traditional Chinese medicine preparation is made from the above-mentioned traditional Chinese medicine composition for treating headaches.

[0016] Furthermore, the traditional Chinese medicine preparation also includes pharmaceutically acceptable excipients. The dosage form of the traditional Chinese medicine preparation is granules, pills, capsules, tablets, powders, or oral liquids.

[0017] Furthermore, the traditional Chinese medicine preparation is an oral liquid.

[0018] A fourth aspect of the invention provides the use of the traditional Chinese medicine composition for treating headaches in the preparation of a medicament for preventing or treating headaches.

[0019] The pharmacological effects of the Chinese medicinal materials involved in the Chinese medicine composition of this invention: Abalone shell: Salty in taste, neutral in nature, enters the liver and kidney meridians, calms the liver and subdues yang, clears the liver and improves vision; used for headache and dizziness, red eyes with pterygium, blurred vision, night blindness, and treating wind-yang disturbance, headache, dizziness, convulsions, bone steaming fever, and night blindness.

[0020] Stir-fried Tribulus terrestris: It has a pungent and bitter taste, is slightly warm in nature, and enters the liver meridian. It can soothe the liver and relieve depression, promote blood circulation and dispel wind, improve eyesight, and relieve itching. It is used for headache and dizziness, chest and rib pain, breast engorgement and mastitis, red eyes with corneal opacity, and wind rash and itching.

[0021] Charred Gardenia: Bitter in taste, cold in nature, enters the heart, lung, and triple burner meridians. It clears heat and relieves irritability, promotes urination, cools blood and detoxifies. It is used for fever with irritability, jaundice with dark urine, painful urination with blood, hematemesis and epistaxis due to blood heat, red and swollen eyes, and sores caused by fire toxins.

[0022] Raw cattail pollen: sweet in taste, neutral in nature, enters the liver and pericardium meridians, stops bleeding, removes blood stasis, and promotes urination; used for hematemesis, epistaxis, hemoptysis, metrorrhagia, traumatic bleeding, amenorrhea, dysmenorrhea, chest and abdominal pain, traumatic swelling and pain, and painful hematuria.

[0023] Angelica sinensis: It is pungent and bitter in taste, warm in nature, and enters the liver, heart, and spleen meridians. It nourishes blood and promotes blood circulation, regulates menstruation and relieves pain, and moistens the intestines and promotes bowel movement. It is used for blood deficiency and chlorosis, dizziness and palpitations, irregular menstruation, amenorrhea and dysmenorrhea, abdominal pain due to deficiency and cold, constipation due to intestinal dryness, rheumatic pain, traumatic injuries, carbuncles and sores.

[0024] Chuanxiong (Ligusticum striatum): It is pungent and warm in nature, and enters the liver and gallbladder meridians. It promotes qi circulation and relieves stagnation, dispels wind and dampness, invigorates blood and relieves pain. It is used for irregular menstruation, amenorrhea and dysmenorrhea, abdominal pain, chest and rib pain, swelling and pain from falls, headache, and rheumatic pain.

[0025] Fangfeng (Saposhnikovia divaricata): It has a pungent and sweet taste, and is slightly warm in nature. It enters the bladder, liver, and spleen meridians. It can dispel dampness, relieve pain, and stop spasms. It is used for colds with headaches, rheumatic pain, urticaria with itching, and tetanus.

[0026] Angelica dahurica: It is pungent and warm in nature. It enters the stomach, large intestine and lung meridians. It relieves exterior syndromes and dispels cold, dispels wind and relieves pain, clears nasal passages, dries dampness and stops leukorrhea, reduces swelling and drains pus. It is used for colds with headache, supraorbital neuralgia, nasal congestion and runny nose, nasal congestion, sinusitis, toothache, leukorrhea, sores and swelling.

[0027] Xu Changqing: It has a pungent taste and warm nature. It enters the stomach and liver meridians. It dispels wind and dampness, relaxes muscles and tendons, reduces swelling and relieves pain, and clears heat and detoxifies. It is used to treat rheumatic pain, muscle and bone contracture, lumbar sprain, colds caused by wind and cold, abdominal distension and pain, toothache, traumatic injuries and other diseases.

[0028] Mother-of-pearl: Salty in taste, cold in nature, enters the liver and heart meridians, calms the liver and subdues yang, soothes the mind and relieves fright, improves eyesight and clears away pterygium; used for headaches and dizziness, palpitations and insomnia, red eyes and pterygium, blurred vision.

[0029] Gastrodia elata: sweet and slightly pungent in taste, neutral in nature, enters the liver meridian, calms wind and stops spasms, suppresses liver yang, dispels wind and unblocks the meridians; used for internal liver wind, epilepsy and convulsions, dizziness, headache, numbness of limbs, hemiplegia, rheumatic pain, etc.

[0030] Prepared licorice root: It is sweet in taste and warm in nature. It enters the heart, lung, stomach, and spleen meridians. It tonifies the spleen and stomach, and replenishes qi and restores the pulse. It is used for spleen and stomach weakness, fatigue, palpitations, and irregular pulse.

[0031] The principles of pain are nothing more than "pain due to obstruction" and "pain due to lack of nourishment". The causes of headaches are primarily wind and blood stasis, and the internal organs involved are mainly the liver and spleen. The pathogenesis is mainly external pathogens, qi stagnation, and blood deficiency. Therefore, when using medicine, we often use products that dispel wind, clear heat, and relieve pain.

[0032] This invention adopts the treatment principle of dispelling wind and unblocking collaterals, clearing heat and relieving pain. The formula contains: abalone shell and gastrodia elata to calm the liver and subdue yang, dispel wind and relieve pain; pearl powder to calm the liver and subdue yang, soothe the mind and calm convulsions; gardenia, bitter and cold, to clear heat from the heart, lungs, and triple burner; stir-fried tribulus terrestris to calm the liver and relieve depression, invigorate blood and dispel wind; chuanxiong and saposhnikovia divaricata to dispel wind and relieve pain; angelica sinensis to invigorate blood, remove blood stasis and unblock collaterals; cynanchum paniculatum to dispel wind, eliminate dampness and relieve pain; raw cattail pollen to stop bleeding and relieve pain; angelica dahurica to dispel wind and relieve pain; and prepared licorice root to harmonize the other herbs. This invention's herbal composition emphasizes a holistic approach and syndrome differentiation, demonstrating unique therapeutic characteristics and advantages in headache treatment compared to Western medicine.

[0033] The beneficial effects of the traditional Chinese medicine composition for treating headaches in this invention are as follows: Animal experiments have shown that the herbal composition of this invention significantly prolongs the time for the appearance of ear redness, shortens the time for the disappearance of ear redness, and significantly reduces the number of times the head is scratched. It can improve the behavioral symptoms of migraine induced by nitroglycerin in rats, exert a pharmacological effect in treating migraine, and provide a safe and effective treatment option for headache. Attached Figure Description

[0034] Figure 1 To compare the time of ear reddening in rats in each group with the normal control group, & P < 0.05 && P < 0.01; compared with the model control group, P < 0.05 P < 0.01; compared with experimental group 1, # P < 0.05 ## P < 0.01.

[0035] Figure 2 To compare the time for the redness to fade in rat ears in each group with the normal control group, & P < 0.05 && P < 0.01; compared with the model control group, P < 0.05 P < 0.01; compared with experimental group 1, # P < 0.05 ## P < 0.01.

[0036] Figure 3 To compare the number of times rats scratched their heads in each group with the normal control group, & P < 0.05 && P < 0.01; compared with the model control group, P < 0.05 P < 0.01; compared with experimental group 1, # P < 0.05 ## P < 0.01. Detailed Implementation

[0037] This application aims to provide the use of a traditional Chinese medicine composition in the preparation of a drug for treating or preventing headaches. To enable those skilled in the art to more clearly understand the technical solution of this application, the following will describe the technical solution of this application in detail with reference to specific embodiments.

[0038] Various modifications and variations can be made to the specific embodiments described in this specification without departing from the scope or spirit of the invention, as will be apparent to those skilled in the art. Other embodiments derived from this specification will also be readily apparent to those skilled in the art. This specification and embodiments are merely exemplary.

[0039] The terms “include,” “including,” “have,” “contain,” etc., used in this article are all open-ended terms, meaning that they include but are not limited to.

[0040] Unless otherwise specified, the following experiments were conducted under standard conditions or the manufacturer's recommendations. The raw materials, excipients, reagents, and instruments used, unless otherwise specified, are all commercially available products. Experimental methods without detailed specifications were conducted according to standard testing methods or the supplier's recommended operating instructions.

[0041] Example 1 This embodiment provides a traditional Chinese medicine composition for treating diabetic nephropathy and its preparation method.

[0042] In this embodiment, the traditional Chinese medicine composition is made from the following components in parts by weight: 30 parts of abalone shell, 15 parts of stir-fried tribulus terrestris, 12 parts of charred gardenia, 15 parts of raw cattail pollen, 12 parts of angelica sinensis, 21 parts of chuanxiong rhizome, 12 parts of saposhnikovia root, 12 parts of angelica dahurica root, 15 parts of cynanchum paniculatum, 30 parts of pearl powder, 15 parts of gastrodia elata, and 6 parts of prepared licorice root.

[0043] The preparation method of the traditional Chinese medicine composition in this embodiment is as follows: weigh each Chinese medicine according to the proportion of raw materials, add 6 times the amount of water, soak for 60 minutes, reflux extract for 50 minutes, filter out the medicinal liquid for later use; add 6 times the amount of water to the residue again, reflux extract for 25 minutes, filter out the medicinal liquid, and combine it with the above medicinal liquid to obtain the final product.

[0044] Example 2 This embodiment provides a traditional Chinese medicine composition for treating diabetic nephropathy and its preparation method.

[0045] In this embodiment, the traditional Chinese medicine composition is made from the following components in parts by weight: 25 parts of abalone shell, 12 parts of stir-fried tribulus terrestris, 10 parts of charred gardenia, 12 parts of raw cattail pollen, 10 parts of angelica sinensis, 18 parts of chuanxiong rhizome, 15 parts of saposhnikovia root, 10 parts of angelica dahurica, 12 parts of cynanchum paniculatum, 35 parts of pearl powder, 12 parts of gastrodia elata, and 4 parts of prepared licorice root.

[0046] The preparation method of the traditional Chinese medicine composition in this embodiment is as follows: weigh each Chinese medicine according to the proportion of raw materials, add 8 times the amount of water, soak for 30 minutes, reflux extract for 60 minutes, filter out the medicinal liquid for later use; add 8 times the amount of water to the residue again, reflux extract for 25 minutes, filter out the medicinal liquid, and combine it with the above medicinal liquid to obtain the final product.

[0047] Example 3 This embodiment provides a traditional Chinese medicine composition for treating diabetic nephropathy and its preparation method.

[0048] In this embodiment, the traditional Chinese medicine composition is made from the following components in parts by weight: 33 parts of abalone shell, 15 parts of stir-fried tribulus terrestris, 15 parts of charred gardenia, 18 parts of raw cattail pollen, 15 parts of angelica sinensis, 24 parts of chuanxiong rhizome, 15 parts of saposhnikovia root, 12 parts of angelica dahurica root, 18 parts of cynanchum paniculatum, 25 parts of pearl powder, 12 parts of gastrodia elata, and 6 parts of prepared licorice root.

[0049] The preparation method of the traditional Chinese medicine composition in this embodiment is as follows: weigh each Chinese medicine according to the proportion of raw materials, add 6 times the amount of water, soak for 60 minutes, reflux extract for 50 minutes, filter out the medicinal liquid for later use; add 6 times the amount of water to the residue again, reflux extract for 25 minutes, filter out the medicinal liquid, and combine it with the above medicinal liquid to obtain the final product.

[0050] Example 4 This embodiment provides a traditional Chinese medicine composition for treating diabetic nephropathy and its preparation method.

[0051] In this embodiment, the traditional Chinese medicine composition is made from the following components in parts by weight: 30 parts of abalone shell, 18 parts of stir-fried tribulus terrestris, 10 parts of charred gardenia, 18 parts of raw cattail pollen, 15 parts of angelica sinensis, 21 parts of chuanxiong rhizome, 10 parts of saposhnikovia root, 15 parts of angelica dahurica, 15 parts of cynanchum paniculatum, 30 parts of pearl powder, 18 parts of gastrodia elata, and 8 parts of prepared licorice root.

[0052] The preparation method of the traditional Chinese medicine composition in this embodiment is as follows: weigh each Chinese medicine according to the proportion of raw materials, add 8 times the amount of water, soak for 30 minutes, reflux extract for 60 minutes, filter out the medicinal liquid for later use; add 8 times the amount of water to the residue again, reflux extract for 35 minutes, filter out the medicinal liquid, and combine it with the above medicinal liquid to obtain the final product.

[0053] Example 5 This embodiment provides a traditional Chinese medicine composition for treating diabetic nephropathy and its preparation method.

[0054] In this embodiment, the traditional Chinese medicine composition is made from the following components in parts by weight: 35 parts of abalone shell, 18 parts of stir-fried tribulus terrestris, 12 parts of charred gardenia, 15 parts of raw cattail pollen, 10 parts of angelica sinensis, 24 parts of chuanxiong rhizome, 10 parts of saposhnikovia root, 15 parts of angelica dahurica, 18 parts of cynanchum paniculatum, 35 parts of pearl powder, 15 parts of gastrodia elata, and 6 parts of prepared licorice root.

[0055] The preparation method of the traditional Chinese medicine composition in this embodiment is as follows: weigh each Chinese medicine according to the proportion of raw materials, add 6 times the amount of water, soak for 60 minutes, reflux extract for 50 minutes, filter out the medicinal liquid for later use; add 6 times the amount of water to the residue again, reflux extract for 25 minutes, filter out the medicinal liquid, and combine it with the above medicinal liquid to obtain the final product.

[0056] Example 6 This embodiment provides a traditional Chinese medicine composition for treating diabetic nephropathy and its preparation method.

[0057] In this embodiment, the traditional Chinese medicine composition is made from the following components in parts by weight: 30 parts of abalone shell, 12 parts of stir-fried tribulus terrestris, 15 parts of charred gardenia, 15 parts of raw cattail pollen, 10 parts of angelica sinensis, 18 parts of chuanxiong rhizome, 15 parts of saposhnikovia root, 10 parts of angelica dahurica, 12 parts of cynanchum paniculatum, 25 parts of pearl powder, 18 parts of gastrodia elata, and 8 parts of prepared licorice root.

[0058] The preparation method of the traditional Chinese medicine composition in this embodiment is as follows: weigh each Chinese medicine according to the proportion of raw materials, add 8 times the amount of water, soak for 30 minutes, reflux extract for 60 minutes, filter out the medicinal liquid for later use; add 8 times the amount of water to the residue again, reflux extract for 25 minutes, filter out the medicinal liquid, and combine it with the above medicinal liquid to obtain the final product.

[0059] Example 7 This embodiment provides a traditional Chinese medicine composition for treating diabetic nephropathy and its preparation method.

[0060] In this embodiment, the traditional Chinese medicine composition is made from the following components in parts by weight: 25 parts of abalone shell, 15 parts of stir-fried tribulus terrestris, 12 parts of charred gardenia, 12 parts of raw cattail pollen, 12 parts of angelica sinensis, 21 parts of chuanxiong rhizome, 12 parts of saposhnikovia root, 12 parts of angelica dahurica root, 15 parts of cynanchum paniculatum, 30 parts of pearl powder, 15 parts of gastrodia elata, and 4 parts of prepared licorice root.

[0061] The preparation method of the traditional Chinese medicine composition in this embodiment is as follows: weigh each Chinese medicine according to the proportion of raw materials, add 6-8 times the amount of water, soak for 30-60 minutes, reflux extract for 50-60 minutes, filter out the medicinal liquid for later use; add 6-8 times the amount of water to the residue again, reflux extract for 25-35 minutes, filter out the medicinal liquid, and combine it with the above medicinal liquid to obtain the final product.

[0062] Comparative Example 1 15 parts of stir-fried Tribulus terrestris, 12 parts of charred Gardenia jasminoides, 15 parts of raw Typha pollen, 12 parts of Angelica sinensis, 21 parts of Ligusticum chuanxiong, 12 parts of Saposhnikovia divaricata, 12 parts of Angelica dahurica, 15 parts of Cynanchum paniculatum, 30 parts of pearl powder, 15 parts of Gastrodia elata, and 6 parts of prepared licorice root.

[0063] Compared with Example 1, the difference is that it does not contain abalone shell, while the other components and amounts remain the same.

[0064] The preparation method is the same as in Example 1.

[0065] Comparative Example 2 30 parts of abalone shell, 15 parts of stir-fried tribulus terrestris, 12 parts of charred gardenia, 15 parts of raw cattail pollen, 12 parts of angelica sinensis, 21 parts of chuanxiong rhizome, 12 parts of saposhnikovia root, 12 parts of angelica dahurica root, 15 parts of cynanchum paniculatum, 15 parts of gastrodia elata, and 6 parts of prepared licorice root.

[0066] Compared with Example 1, the difference is that it does not contain mother-of-pearl, while the other components and amounts remain the same.

[0067] The preparation method is the same as in Example 1.

[0068] Comparative Example 3 The formula disclosed in Example 1 of Chinese Patent CN109954097B is as follows: Bupleurum chinense 15 parts, Codonopsis pilosula 8 parts, Scutellaria baicalensis 8 parts, Ligusticum chuanxiong 5 parts, Corydalis yanhusuo 5 parts, Chrysanthemum morifolium 4 parts, Morus alba 4 parts, Vitex trifolia 4 parts, Gastrodia elata 10 parts, Uncaria rhynchophylla 10 parts, Poria cocos 8 parts, Lophatherum gracile 8 parts, and Ilex chinensis 8 parts.

[0069] The preparation method is the same as in Example 1.

[0070] animal testing The following specific experimental examples demonstrate the effectiveness of the present invention. The rat experimental migraine model induced by nitroglycerin exhibits behavioral symptoms such as red ears, frequent head scratching with forelimbs, and increased climbing frequency. These symptoms can objectively and quantitatively reflect the severity of migraine in the model animals. These behavioral symptoms are somewhat similar to those observed during a human migraine attack. Furthermore, this model is widely used because it is easy to operate due to its simple modeling factors and allows for conscious observation of behavioral changes in the animals.

[0071] Study on the effect of the traditional Chinese medicine composition of the present invention on headache model rats 1. Experimental Methods Forty-eight SPF-grade SD rats, weighing 160-200g, were randomly divided into four groups using a random number method: a normal control group (0.1mL / 10g saline), a model control group (0.1mL / 10g saline), experimental group 1 (herbal composition from Example 1, 22.8g crude drug / kg), experimental group 2 (herbal composition from Example 2, 22.8g crude drug / kg), experimental group 3 (herbal composition from Example 3, 22.8g crude drug / kg), control group 1 (herbal composition from Comparative Example 1, 22.8g crude drug / kg), control group 2 (herbal composition from Comparative Example 2, 22.8g crude drug / kg), and control group 3 (herbal composition from Comparative Example 3, 22.8g crude drug / kg), with six rats in each group.

[0072] Each group was administered the corresponding dose of medication by gavage once a day for 5 consecutive days.

[0073] One hour after the last administration, the normal control group was injected subcutaneously with physiological saline at 10 mg / kg, while the rats in the other groups were injected subcutaneously with nitroglycerin at 10 mg / kg in the right shoulder.

[0074] After successful modeling, the rats exhibited behavioral symptoms such as red ears, frequent head scratching with forelimbs, and increased cage climbing frequency.

[0075] 2. Detection indicators Observe the time of appearance and disappearance of red ears in rats after modeling, and record the number of times rats scratch their heads within 120 minutes.

[0076] 3. Statistical Methods Data processing was performed using GraphPad Prism 8.0 software, with the measurement data presented in... ±s indicates that statistical differences between groups were compared using one-way ANOVA, and P<0.05 indicates that the difference was statistically significant.

[0077] 4. Experimental Results 4.1 Effects on the appearance and disappearance time of redness in rat ears Table 1 Results of ear redness appearance and disappearance time for each group Note: Compared with the normal control group, & P < 0.05 && P < 0.01; Compared with the model control group, P < 0.05 P < 0.01; Compared with Experiment 1, # P < 0.05 ## P < 0.01.

[0078] Compared with the normal control group, the rats in the model control group had a significantly shorter ear redness appearance time and a significantly longer disappearance time.

[0079] Compared with the model control group, the time for the appearance of redness in the ears of rats in experimental groups 1, 2, and 3 was significantly prolonged, while the time for its disappearance was significantly shortened.

[0080] Compared with control groups 1-3, experimental groups 1, 2, and 3 showed better results in prolonging the appearance time of ear redness and shortening the disappearance time of ear redness. The results are shown in Table 1. Figure 1 , Figure 2 .

[0081] 4.2 Effect on the number of times rats scratch their heads See results Figure 3 Compared with the normal control group, the number of times the rats in the model control group scratched their heads increased significantly.

[0082] Compared with the model control group, the number of times rats scratched their heads was significantly reduced in experimental groups 1, 2 and 3.

[0083] Compared with control groups 1-3, experimental groups 1, 2, and 3 showed a better effect in reducing the number of times the head was scratched.

[0084] The herbal composition of this invention significantly prolongs the time for the appearance of ear redness, shortens the time for the disappearance of ear redness, and significantly reduces the number of times the head is scratched. It can improve the behavioral symptoms of nitroglycerin-induced migraine in rats and exert a pharmacological effect in treating migraine.

[0085] Comparative Example 1 did not contain abalone shell, and Comparative Example 2 did not contain mother-of-pearl. Compared with the control groups 1-3, the improvement effects of each indicator in experimental groups 1, 2, and 3 were more significant, proving that the components of the traditional Chinese medicine composition of the present invention are indispensable and have a synergistic effect in the treatment of headache.

[0086] Compared with the formulation of Comparative Example 3, the components of the traditional Chinese medicine composition of the present invention have superior technical effects in treating headaches.

[0087] The above embodiments of the present invention are merely illustrative examples to clearly illustrate the invention, and are not intended to limit the implementation of the invention. Those skilled in the art will recognize that other variations or modifications can be made based on the above description. It is neither necessary nor possible to exhaustively describe all possible implementations. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention should be included within the scope of protection of the claims of the present invention.

Claims

1. A traditional Chinese medicine composition for treating headaches, characterized in that, The traditional Chinese medicine composition for treating headaches contains the following components by weight: 25-35 parts of abalone shell, 12-18 parts of stir-fried tribulus terrestris, 10-15 parts of charred gardenia, 12-18 parts of raw cattail pollen, 10-15 parts of angelica sinensis, 18-24 parts of chuanxiong rhizome, 10-15 parts of saposhnikovia root, 10-15 parts of angelica dahurica, 12-18 parts of cynanchum paniculatum, 25-35 parts of pearl powder, 12-18 parts of gastrodia elata, and 4-8 parts of prepared licorice root.

2. The traditional Chinese medicine composition for treating headaches according to claim 1, characterized in that, The traditional Chinese medicine composition for treating headaches contains the following components by weight: 30 parts of abalone shell, 15 parts of stir-fried tribulus terrestris, 12 parts of charred gardenia, 15 parts of raw cattail pollen, 12 parts of angelica sinensis, 21 parts of chuanxiong rhizome, 12 parts of saposhnikovia root, 12 parts of angelica dahurica root, 15 parts of cynanchum paniculatum, 30 parts of pearl powder, 15 parts of gastrodia elata, and 6 parts of prepared licorice root.

3. The traditional Chinese medicine composition for treating headaches according to claim 1, characterized in that, The traditional Chinese medicine composition for treating headaches contains the following components by weight: 25 parts of abalone shell, 12 parts of stir-fried tribulus terrestris, 10 parts of charred gardenia, 12 parts of raw cattail pollen, 10 parts of angelica sinensis, 18 parts of chuanxiong rhizome, 15 parts of saposhnikovia root, 10 parts of angelica dahurica, 12 parts of cynanchum paniculatum, 35 parts of pearl powder, 12 parts of gastrodia elata, and 4 parts of prepared licorice root.

4. The traditional Chinese medicine composition for treating headaches according to claim 1, characterized in that, The traditional Chinese medicine composition for treating headaches contains the following components by weight: 33 parts of abalone shell, 15 parts of stir-fried tribulus terrestris, 15 parts of charred gardenia, 18 parts of raw cattail pollen, 15 parts of angelica sinensis, 24 parts of chuanxiong rhizome, 15 parts of saposhnikovia root, 12 parts of angelica dahurica root, 18 parts of cynanchum paniculatum, 25 parts of pearl powder, 12 parts of gastrodia elata, and 6 parts of prepared licorice root.

5. A method for preparing a traditional Chinese medicine composition for treating headaches as described in any one of claims 1-4, characterized in that, The preparation method includes the following steps: weigh each Chinese herbal medicine according to the proportion of raw materials, add 6-8 times the amount of water, soak for 30-60 minutes, reflux extract for 50-60 minutes, filter out the medicinal liquid for later use; add 6-8 times the amount of water to the residue again, reflux extract for 25-35 minutes, filter out the medicinal liquid, and combine it with the above medicinal liquid to obtain the final product.

6. The method for preparing the traditional Chinese medicine composition for treating headache according to claim 5, characterized in that, The preparation method includes the following steps: weigh each Chinese herbal medicine according to the proportion of raw materials, add 6 times the amount of water, soak for 60 minutes, reflux extract for 50 minutes, filter out the medicinal liquid for later use; add 6 times the amount of water to the residue again, reflux extract for 25 minutes, filter out the medicinal liquid, and combine it with the above medicinal liquid to obtain the final product.

7. A traditional Chinese medicine preparation comprising a traditional Chinese medicine composition for treating headaches, characterized in that, The traditional Chinese medicine preparation is made from the traditional Chinese medicine composition for treating headaches as described in any one of claims 1-4.

8. The traditional Chinese medicine preparation of the herbal composition for treating headache according to claim 7, characterized in that, The traditional Chinese medicine preparation also includes pharmaceutically acceptable excipients, and the dosage form of the traditional Chinese medicine preparation is granules, pills, capsules, tablets, powders or oral liquids.

9. The traditional Chinese medicine preparation of the herbal composition for treating headache according to claim 7, characterized in that, The traditional Chinese medicine preparation is an oral liquid.

10. Use of the traditional Chinese medicine composition for treating headache according to any one of claims 1-4 in the preparation of a medicament for preventing or treating headache.

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