Traditional Chinese medicine composition for treating lung cancer

Abstract

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating lung cancer. The traditional Chinese medicine composition comprises 15-60 parts of radix pseudostellariae, 6-24 parts of radix ophiopogonis, 3-12 parts of schisandra chinensis, 6-24 parts of pulp of dogwood fruit, 7-30 parts of wine-processed rhizoma polygonati, 7-30 parts of dandelion, 15-60 parts of oldenlandia diffusa, 5-20 parts of rhizoma sparganii, 4-18 parts of curcuma zedoary, 1-6 parts of taxus chinensis var mairei, 5-20 parts of pericarpium citri reticulatae, 7-30 parts of selfheal, 5-20 parts of platycodon grandiflorum, 15-60 parts of radix ranunculi ternati and 5-20 parts of liquorice. According to the traditional Chinese medicine composition disclosed by the invention, five medicines such as radix pseudostellariae, radix ophiopogonis, schisandra chinensis, polygonatum kingianum and pulp of dogwood fruit can tonify qi and yin, regulate and tonify lung and kidney and regulate lung and kidney simultaneously, and according to different treatment stages of cough and asthma diseases, the medicines such as dandelion, oldenlandia diffusa, rhizoma sparganii and curcuma zedoary are added or reduced according to syndrome differentiation, so that the effects of promoting blood circulation and removing stasis are achieved; combined chemotherapy / targeted therapy can effectively improve the problems of adverse reaction and drug resistance of lung cancer patients, and the effects of reducing toxicity and improving efficacy are achieved.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, and in particular to a traditional Chinese medicine composition for treating lung cancer. Background Technology

[0002] Lung cancer is a malignant tumor originating from the bronchial mucosa or glands of the lungs. It is one of the leading causes of cancer-related deaths worldwide, and its incidence is closely related to various factors such as smoking, air pollution, occupational exposure, and genetics. Currently, the diagnosis of lung cancer requires a combination of imaging examinations and pathological biopsies. Treatment methods include surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy. The specific treatment plan needs to be comprehensively formulated based on the patient's pathological type, stage, and gene testing results. Early detection, early diagnosis, and early treatment are key to improving the survival rate of lung cancer patients.

[0003] Currently, research on lung cancer has always been a key focus and challenge in tumor research. PD-1 / PD-L1 immunotherapy can significantly improve patient survival rates and produce lasting efficacy. Compared with radiotherapy and chemotherapy, it can effectively improve patients' quality of life. However, its clinical efficacy rate is only about 20%, which cannot meet the huge clinical demand. Therefore, finding an important combination that can improve the sensitivity of lung cancer to immunotherapy is of great significance. Summary of the Invention

[0004] To address the aforementioned problems, this invention aims to provide a traditional Chinese medicine composition for treating lung cancer, which improves the sensitivity of lung cancer to immunotherapy, thereby enhancing the efficacy of immunotherapy.

[0005] To achieve the above objectives, the technical solution adopted by the present invention to solve its technical problem is as follows: A traditional Chinese medicine composition for treating lung cancer includes the following ingredients: Codonopsis pilosula, Ophiopogon japonicus, Schisandra chinensis, Cornus officinalis, Polygonatum sibiricum, Taraxacum mongolicum, Hedyotis diffusa, Sparganium stoloniferum, Curcuma zedoaria, Taxus wallichiana, Citrus reticulata peel, Prunella vulgaris, Platycodon grandiflorus, Uncaria rhynchophylla, and Glycyrrhiza uralensis. The weight proportions of different raw materials are as follows: Codonopsis pilosula 15-60 parts, Ophiopogon japonicus 6-24 parts, Schisandra chinensis 3-12 parts, Cornus officinalis 6-24 parts, Polygonatum sibiricum 7-30 parts, Taraxacum mongolicum 7-30 parts, Hedyotis diffusa 15-60 parts, Sparganium stoloniferum 5-20 parts, Curcuma zedoaria 4-18 parts, Taxus wallichiana 1-6 parts, Citrus reticulata 5-20 parts, Prunella vulgaris 7-30 parts, Platycodon grandiflorus 5-20 parts, Uncaria rhynchophylla 15-60 parts, and Glycyrrhiza uralensis 5-20 parts; Furthermore, the weight proportions of different raw materials are as follows: 30 parts of Codonopsis pilosula, 12 parts of Ophiopogon japonicus, 6 parts of Schisandra chinensis, 12 parts of Cornus officinalis, 15 parts of Polygonatum sibiricum, 15 parts of Taraxacum mongolicum, 30 parts of Hedyotis diffusa, 10 parts of Sparganium stoloniferum, 9 parts of Curcuma zedoaria, 3 parts of Taxus wallichiana, 10 parts of Citrus reticulata peel, 15 parts of Prunella vulgaris, 10 parts of Platycodon grandiflorus, 30 parts of Uncaria rhynchophylla, and 10 parts of Glycyrrhiza uralensis.

[0006] The pharmacological effects of the different raw materials in this invention are as follows: Chief herb: Codonopsis pilosula The formula uses Codonopsis pilosula, a mild herb known for its "clearing and tonifying" properties, as the chief ingredient, replacing the traditionally strong "warming and tonifying" ginseng. Codonopsis pilosula is moistening without being drying, and can greatly tonify the qi of the lungs and spleen, as well as nourish yin fluids. It is especially suitable for lung cancer patients with both qi and yin deficiency and dryness and heat. It perfectly avoids the drawback of further damaging yin fluids with warming and drying herbs. As Zhang Xichun said in "Medical Records of Integrating Chinese and Western Medicine": "American ginseng is cool and tonifying. It can be used as a substitute for ginseng for those who want to use ginseng but cannot tolerate its warming and tonifying properties."

[0007] Assistant herb: Ophiopogon japonicus I believe that Ophiopogon japonicus, which is sweet, cold, and moistening, is a "nourishing and tonifying herb." Its nature is moistening without being greasy. It not only "enters the stomach to nourish the stomach fluids" but also "enters the spleen to help the spleen disperse essence to the lungs, relieve asthma and cough." It moistens lung dryness to relieve asthma and cough, nourishes stomach yin to generate body fluids, and its moistening nature moistens dryness without harming the stomach, and nourishes yin without the risk of retaining pathogens.

[0008] Adjuvant: Schisandra chinensis Combined with the sour, sweet, and warm properties of Schisandra chinensis, this product perfectly integrates the dual effects of astringing and consolidating while replenishing qi and generating fluids. It can astringe lung qi to prevent its dissipation, consolidate body fluids to protect stomach qi, and absorb kidney essence to strengthen the foundation. Crucially, Schisandra chinensis contains both sourness and spiciness. Sourness is the essence (to astringe and prevent the dissipation of lung qi), while spiciness is the function (to disperse and relieve qi stagnation). It not only allows heart fire to descend to the kidneys and kidney water to ascend to the heart, but also achieves a subtle and harmonious state of "astringing without stagnation and dispersing without harming the body's vital energy." As Zhang Jingyue stated, "Schisandra chinensis specifically replenishes kidney water and also benefits lung metal. Sourness astringes it, and spiciness promotes its movement, allowing heart fire to descend and kidney water to ascend." The "Seeking Truth in Materia Medica" also aptly points out that "when water qi rises and causes cough, this sour and sweet-soothing formula is indispensable. However, its astringent nature combined with its dispersing properties is what makes it effective against illness."

[0009] Medicinal herb: Licorice Licorice is used to harmonize the various herbs, invigorate qi and regulate the middle jiao, relieve urgency and detoxify, moderate the properties of the strong herbs, protect the stomach and calm the middle jiao, so that the whole prescription can eliminate evil without being too strong and support the body without being stagnant. It is further combined with Polygonatum sibiricum and Cornus officinalis for synergistic effects. Polygonatum sibiricum is sweet and neutral in nature, and is good at moistening the lungs, tonifying the spleen yin, and replenishing the kidney essence. It is mild and nourishing without being drying, and nourishing without being greasy. As stated in the Compendium of Materia Medica: "Its nature is mild and nourishing, neither cold nor dry... It receives the pure qi of earth, so it is a superior product for tonifying the liver. Earth is the mother of all things. When the mother is nourished, water and fire are in balance, wood and metal are in harmony, and all evils will be eliminated, and no disease will arise." Cornus officinalis is warm and mild, nourishing without being drastic. It can nourish the liver and kidneys, replenish essence and blood, and also has the properties of dispersing and circulating within its sour and astringent properties. The Commentary on the Materia Medica explains its meaning: "Warmth can promote circulation, pungentness can disperse, sourness can enter the liver... It is warm and mainly nourishing, and sourness can mainly astringe. Therefore, when essence and qi are benefited, yin is strengthened. When essence is benefited, the five internal organs are at peace and the nine orifices are unobstructed." The five core ingredients work together to not only achieve the great effects of invigorating qi and nourishing yin, astringing yin and generating fluids, but also implicitly contain the therapeutic ingenuity of "strengthening earth to generate metal" (tonifying the spleen to benefit the lungs) and "metal and water generating each other" (tonifying the lungs to nourish the kidneys). This makes the whole formula have both sour and astringent properties as well as pungent and dispersing properties to regulate qi, nourish yin without hindering pathogens, and astringe without causing stagnation. It fully reflects the academic thought of the formula maker who is flexible and adaptable.

[0010] Lung cancer is not a purely deficiency syndrome; it is often a combination of deficiency and excess, with both superficial excess and underlying deficiency coexisting. Deficiency of Qi and Yin leads to abnormal distribution of body fluids, resulting in phlegm accumulation; Qi deficiency weakens the body's ability to propel blood, causing blood stasis; Yin deficiency generates internal heat, scorching body fluids, or combining with external pathogens, easily producing toxins. Phlegm, blood stasis, and toxins intertwine to form masses and lumps, which is the essence of "lumps." Therefore, in addition to strongly supporting the body's vital energy, the formula also includes a series of precisely targeted herbs to dispel pathogens and resolve lumps. Tangerine peel is bitter, pungent, and warm; it regulates Qi, removes stagnation, dries dampness, and resolves phlegm. Its mild nature invigorates the spleen and stomach, ensuring that the entire formula nourishes without harming the stomach, resolves phlegm without damaging the body's vital energy, and guarantees the smooth functioning of the middle Jiao (middle burner). Both Sparganium rhizome and Curcuma zedoaria are powerful herbs for breaking up blood stasis, promoting qi circulation, eliminating stagnation, and relieving pain. They are often used together. Curcuma zedoaria is good at breaking up blood stasis within qi, while Sparganium rhizome is good at breaking up qi stasis within blood. Together, they can penetrate deep into the blood vessels, breaking up stubborn blood stasis and masses, clearing the channels, and relieving pain. Although their effects are strong, they are protected by a large number of qi-tonifying and yin-nourishing herbs in the preceding prescription, thus eliminating pathogens without harming the body's vital energy, embodying the strategy of "combining attack and tonification." Taxus chinensis, Taraxacum mongolicum, Hedyotis diffusa, Uncaria rhynchophylla, and Prunella vulgaris together form a powerful team for clearing heat, detoxifying, reducing swelling, and dispersing nodules. Modern research has shown that yew has anti-tumor effects, while traditional Chinese medicine considers it to have detoxifying and nodule-dispersing properties. Dandelion is bitter, sweet, and cold, clearing heat and detoxifying, reducing swelling and dispersing nodules, and promoting diuresis and relieving strangury. Although its nature is cold, it is not too drastic and can clear away stagnant heat and toxins. Oldenlandia diffusa is bitter, sweet, and cold, clearing heat and promoting diuresis, detoxifying and reducing swelling. It is widely used in modern times for various types of masses and tumors, taking advantage of its effects of clearing heat and detoxifying, promoting blood circulation and reducing swelling. Uncaria rhynchophylla is pungent, sweet, and warm, resolving phlegm and dispersing nodules, detoxifying and reducing swelling, and is especially good at treating scrofula and phlegm nodules. Prunella vulgaris is bitter, pungent, and cold, clearing liver fire and dispersing stagnation, and is an essential medicine for treating goiter and scrofula. Although this group of drugs differs in their cold and warm properties, they all share the same goal of clearing heat and detoxifying, softening and dispersing nodules, and jointly target the core pathogenesis of "toxic nodules," directly attacking the disease site. Furthermore, the addition of Platycodon grandiflorus, which is bitter, pungent, and neutral, specifically enters the lung meridian. It excels at opening and dispersing lung qi, eliminating phlegm and draining pus, and can also carry the medicine upward, guiding the power of other medicines directly to the lung system. Combined with licorice root, which descends, it achieves the wonderful effect of mutual promotion and demotion.

[0011] Furthermore, the preparation method of the traditional Chinese medicine composition for treating lung cancer includes the following steps: S1: Soaking: Add 10 times the amount of water to Codonopsis pilosula, Ophiopogon japonicus, Schisandra chinensis, Cornus officinalis, Polygonatum sibiricum, Taraxacum mongolicum, Hedyotis diffusa, Sparganium stoloniferum, Curcuma zedoaria, Taxus wallichiana, Citrus reticulata, Prunella vulgaris, Platycodon grandiflorus, Uncaria rhynchophylla, and Glycyrrhiza uralensis, and soak for 30 minutes. S2: Decoction: Heat to a boil and then keep simmering for 40 minutes. Pour out the decoction. Add 8 times the amount of water to the residue, heat to a boil and keep simmering for 40 minutes. Combine the two decoctions, filter, and collect the filtrate. S3: Concentration: Concentrate the above decoction using a rotary evaporator at 65°C and under reduced pressure until the concentration is 1.41 g / ml. Store at -20°C for later use.

[0012] The beneficial effects of this invention are: 1. This invention attributes the pathogenesis of lung cancer to a deficiency of vital energy and an excess of pathogenic factors. It believes that lung cancer surgery, radiotherapy, chemotherapy, and targeted drug therapy often deplete qi and yin, leading to deficiency of the lung and spleen. Over time, this can damage kidney qi. Patients often experience fatigue, shortness of breath, chest tightness, which worsens with activity, cough with phlegm, and loss of appetite. The etiology can be summarized as "deficiency, phlegm, blood stasis, and toxins," with deficiency of qi and yin as the root cause, and phlegm stagnation, blood stasis, and toxin accumulation as the symptoms. Treatment should focus on strengthening the body's resistance and eliminating pathogenic factors, addressing both the root cause and the symptoms. Based on the principle of "strengthening the body's resistance and eliminating pathogenic factors," herbs such as Polygonatum sibiricum, Taraxacum mongolicum, Hedyotis diffusa, Sparganium stoloniferum, Curcuma zedoaria, Taxus wallichiana, Citrus reticulata, Prunella vulgaris, Platycodon grandiflorus, Uncaria rhynchophylla, and Glycyrrhiza uralensis work synergistically. Among them, dandelion, oldenlandia diffusa, and cat's claw grass mainly play the role of clearing heat and detoxifying, and modern research suggests that they may inhibit the activity of tumor cells; tangerine peel, prunella vulgaris, and platycodon grandiflorus are good at resolving phlegm and dissipating nodules, aiming to improve cough with excessive phlegm and dissipate nodules; sparganium and turmeric are a classic herb pair for promoting blood circulation and removing blood stasis, which helps to improve the tumor microenvironment, relieve pain and inhibit metastasis; while polygonatum sibiricum and licorice focus on supporting the body's vital energy and tonifying the spleen and stomach to enhance the patient's overall immune function and tolerance. It should be noted that paclitaxel, an extract of Taxus chinensis, is an important drug in modern lung cancer chemotherapy, and its application in the compound also reflects the idea of ​​combining traditional Chinese and Western medicine.

[0013] 2. This invention, by adding Codonopsis pilosula, Ophiopogon japonicus, Schisandra chinensis, Polygonatum sibiricum, and Cornus officinalis, deeply understands the essence of "Shengmai Yin" in replenishing qi, astringing yin, and generating fluids. It also ingeniously innovates and modifies the formula. The five ingredients work together to not only achieve the great effect of replenishing qi and nourishing yin, astringing yin and generating fluids, but also implicitly contain the therapeutic ideas of "strengthening earth to generate metal" (tonifying the spleen to benefit the lungs) and "metal and water generating each other" (tonifying the lungs to nourish the kidneys). The whole formula has both sour and astringent properties as well as pungent and dispersing properties to regulate qi. It nourishes yin without hindering the elimination of pathogens and astringes without causing stagnation. It fully reflects the academic thought of the formula maker who is flexible and adaptable.

[0014] 3. This invention incorporates dried tangerine peel, sparganium rhizome, and curcuma rhizome. Dried tangerine peel is bitter, pungent, and warm, regulating qi and relieving stagnation, drying dampness and resolving phlegm. Its mild nature can invigorate the spleen and stomach, ensuring that the entire formula is nourishing without harming the stomach, and resolving phlegm without damaging the body's vital energy, thus guaranteeing the smooth functioning of the middle jiao. Sparganium rhizome and curcuma rhizome are often used together. Curcuma rhizome is good at breaking up blood stasis in qi, while sparganium rhizome is good at breaking up qi in blood. Together, they can penetrate deep into the blood vessels, break up stubborn blood stasis and masses, and relieve pain by clearing the channels. Although their effects are strong, they are protected by a large amount of qi-tonifying and yin-nourishing herbs in the preceding formula, thus eliminating pathogens without harming the body's vital energy, embodying the strategy of "combining attack and tonification".

[0015] 4. This invention incorporates yew, dandelion, oldenlandia diffusa, cat's claw herb, and prunella vulgaris to form a powerful team for clearing heat and detoxifying, reducing swelling and dissipating nodules. Yew has the effect of detoxifying and dissipating nodules. Although dandelion is cold in nature, it is not too drastic and can clear away stagnant heat and toxins. Oldenlandia diffusa has the effects of clearing heat and detoxifying, promoting blood circulation and reducing swelling. Cat's claw herb is good at treating scrofula and phlegm nodules. Prunella vulgaris is an essential medicine for treating goiter and scrofula. Although the medicinal properties of this group of drugs differ in their cold and warm nature, their goals of clearing heat and detoxifying, softening hardness and dissipating nodules are consistent. They jointly target the core pathogenesis of "toxic nodules" and directly attack the disease site.

[0016] 5. By adding Platycodon grandiflorus and Glycyrrhiza uralensis to this invention, Platycodon grandiflorus is good at opening up lung qi, eliminating phlegm and draining pus, and can carry the medicine upward, guiding the power of the medicine directly to the lung system. When combined with Glycyrrhiza uralensis which descends, it forms a wonderful effect of mutual ascending and descending. Glycyrrhiza uralensis is sweet and mild, which harmonizes the medicine, benefits qi and harmonizes the middle jiao, relieves urgency and detoxifies, moderates the nature of the strong medicine, protects the stomach and calms the middle jiao, so that the whole formula eliminates evil without being too strong and supports the body without causing stagnation. Attached Figure Description

[0017] Figure 1 This shows the changes in tumor volume over 15 days in Example 2; Figure 2 This refers to the tumor regression within 15 days in Example 2; Figure 3 This is a comparison chart of tumor weights in Example 2; Figure 4 This is a diagram showing the tumor epigenetic results in Example 2; Figure 5 This is a graph showing the organ coefficient results in Example 2; Figure 6 This is a blood routine test result from Example 2. Detailed Implementation

[0018] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention. Example 1

[0019] A traditional Chinese medicine composition for treating lung cancer includes the following ingredients: Codonopsis pilosula, Ophiopogon japonicus, Schisandra chinensis, Cornus officinalis, Polygonatum sibiricum, Taraxacum mongolicum, Hedyotis diffusa, Sparganium stoloniferum, Curcuma zedoaria, Taxus wallichiana, Citrus reticulata peel, Prunella vulgaris, Platycodon grandiflorus, Uncaria rhynchophylla, and Glycyrrhiza uralensis. The weight proportions of different raw materials are as follows: 30 parts of Codonopsis pilosula, 12 parts of Ophiopogon japonicus, 6 parts of Schisandra chinensis, 12 parts of Cornus officinalis, 15 parts of Polygonatum sibiricum, 15 parts of Taraxacum mongolicum, 30 parts of Hedyotis diffusa, 10 parts of Sparganium stoloniferum, 9 parts of Curcuma zedoaria, 3 parts of Taxus wallichiana, 10 parts of Citrus reticulata peel, 15 parts of Prunella vulgaris, 10 parts of Platycodon grandiflorus, 30 parts of Uncaria rhynchophylla, and 10 parts of Glycyrrhiza uralensis.

[0020] The pharmacological properties of the different raw materials in this invention are as follows: Chief herb: Codonopsis pilosula The formula uses Codonopsis pilosula, a mild herb known for its "clearing and tonifying" properties, as the chief ingredient, replacing the traditionally strong "warming and tonifying" ginseng. Codonopsis pilosula is moistening without being drying, and can greatly tonify the qi of the lungs and spleen, as well as nourish yin fluids. It is especially suitable for lung cancer patients with both qi and yin deficiency and dryness and heat. It perfectly avoids the drawback of further damaging yin fluids with warming and drying herbs. As Zhang Xichun said in "Medical Records of Integrating Chinese and Western Medicine": "American ginseng is cool and tonifying. It can be used as a substitute for ginseng for those who want to use ginseng but cannot tolerate its warming and tonifying properties."

[0021] Assistant herb: Ophiopogon japonicus I believe that Ophiopogon japonicus, which is sweet, cold, and moistening, is a "nourishing and tonifying herb." Its nature is moistening without being greasy. It not only "enters the stomach to nourish the stomach fluids" but also "enters the spleen to help the spleen disperse essence to the lungs, relieve asthma and cough." It moistens lung dryness to relieve asthma and cough, nourishes stomach yin to generate body fluids, and its moistening nature moistens dryness without harming the stomach, and nourishes yin without the risk of retaining pathogens.

[0022] Adjuvant: Schisandra chinensis Combined with the sour, sweet, and warm properties of Schisandra chinensis, this product perfectly integrates the dual effects of astringing and consolidating while replenishing qi and generating fluids. It can astringe lung qi to prevent its dissipation, consolidate body fluids to protect stomach qi, and absorb kidney essence to strengthen the foundation. Crucially, Schisandra chinensis contains both sourness and spiciness. Sourness is the essence (to astringe and prevent the dissipation of lung qi), while spiciness is the function (to disperse and relieve qi stagnation). It not only allows heart fire to descend to the kidneys and kidney water to ascend to the heart, but also achieves a subtle and harmonious state of "astringing without stagnation and dispersing without harming the body's vital energy." As Zhang Jingyue stated, "Schisandra chinensis specifically replenishes kidney water and also benefits lung metal. Sourness astringes it, and spiciness promotes its movement, allowing heart fire to descend and kidney water to ascend." The "Seeking Truth in Materia Medica" also aptly points out that "when water qi rises and causes cough, this sour and sweet-soothing formula is indispensable. However, its astringent nature combined with its dispersing properties is what makes it effective against illness."

[0023] Medicinal herb: Licorice Licorice is used to harmonize the various herbs, invigorate qi and regulate the middle jiao, relieve urgency and detoxify, moderate the properties of the strong herbs, protect the stomach and calm the middle jiao, so that the whole prescription can eliminate evil without being too strong and support the body without being stagnant. It is further combined with Polygonatum sibiricum and Cornus officinalis for synergistic effects. Polygonatum sibiricum is sweet and neutral in nature, and is good at moistening the lungs, tonifying the spleen yin, and replenishing the kidney essence. It is mild and nourishing without being drying, and nourishing without being greasy. As stated in the Compendium of Materia Medica: "Its nature is mild and nourishing, neither cold nor dry... It receives the pure qi of earth, so it is a superior product for tonifying the liver. Earth is the mother of all things. When the mother is nourished, water and fire are in balance, wood and metal are in harmony, and all evils will be eliminated, and no disease will arise." Cornus officinalis is warm and mild, nourishing without being drastic. It can nourish the liver and kidneys, replenish essence and blood, and also has the properties of dispersing and circulating within its sour and astringent properties. The Commentary on the Materia Medica explains its meaning: "Warmth can promote circulation, pungentness can disperse, sourness can enter the liver... It is warm and mainly nourishing, and sourness can mainly astringe. Therefore, when essence and qi are benefited, yin is strengthened. When essence is benefited, the five internal organs are at peace and the nine orifices are unobstructed." The five core ingredients work together to not only achieve the great effects of invigorating qi and nourishing yin, astringing yin and generating fluids, but also implicitly contain the therapeutic ingenuity of "strengthening earth to generate metal" (tonifying the spleen to benefit the lungs) and "metal and water generating each other" (tonifying the lungs to nourish the kidneys). This makes the whole formula have both sour and astringent properties as well as pungent and dispersing properties to regulate qi, nourish yin without hindering pathogens, and astringe without causing stagnation. It fully reflects the academic thought of the formula maker who is flexible and adaptable.

[0024] Lung cancer is not a purely deficiency syndrome; it is often a combination of deficiency and excess, with both superficial excess and underlying deficiency coexisting. Deficiency of Qi and Yin leads to abnormal distribution of body fluids, resulting in phlegm accumulation; Qi deficiency weakens the body's ability to propel blood, causing blood stasis; Yin deficiency generates internal heat, scorching body fluids, or combining with external pathogens, easily producing toxins. Phlegm, blood stasis, and toxins intertwine to form masses and lumps, which is the essence of "lumps." Therefore, in addition to strongly supporting the body's vital energy, the formula also includes a series of precisely targeted herbs to dispel pathogens and resolve lumps. Tangerine peel is bitter, pungent, and warm; it regulates Qi, removes stagnation, dries dampness, and resolves phlegm. Its mild nature invigorates the spleen and stomach, ensuring that the entire formula nourishes without harming the stomach, resolves phlegm without damaging the body's vital energy, and guarantees the smooth functioning of the middle Jiao (middle burner). Both Sparganium rhizome and Curcuma zedoaria are powerful herbs for breaking up blood stasis, promoting qi circulation, eliminating stagnation, and relieving pain. They are often used together. Curcuma zedoaria is good at breaking up blood stasis within qi, while Sparganium rhizome is good at breaking up qi stasis within blood. Together, they can penetrate deep into the blood vessels, breaking up stubborn blood stasis and masses, clearing the channels, and relieving pain. Although their effects are strong, they are protected by a large number of qi-tonifying and yin-nourishing herbs in the preceding prescription, thus eliminating pathogens without harming the body's vital energy, embodying the strategy of "combining attack and tonification." Taxus chinensis, Taraxacum mongolicum, Hedyotis diffusa, Uncaria rhynchophylla, and Prunella vulgaris together form a powerful team for clearing heat, detoxifying, reducing swelling, and dispersing nodules. Modern research has shown that yew has anti-tumor effects, while traditional Chinese medicine considers it to have detoxifying and nodule-dispersing properties. Dandelion is bitter, sweet, and cold, clearing heat and detoxifying, reducing swelling and dispersing nodules, and promoting diuresis and relieving strangury. Although its nature is cold, it is not too drastic and can clear away stagnant heat and toxins. Oldenlandia diffusa is bitter, sweet, and cold, clearing heat and promoting diuresis, detoxifying and reducing swelling. It is widely used in modern times for various types of masses and tumors, taking advantage of its effects of clearing heat and detoxifying, promoting blood circulation and reducing swelling. Uncaria rhynchophylla is pungent, sweet, and warm, resolving phlegm and dispersing nodules, detoxifying and reducing swelling, and is especially good at treating scrofula and phlegm nodules. Prunella vulgaris is bitter, pungent, and cold, clearing liver fire and dispersing stagnation, and is an essential medicine for treating goiter and scrofula. Although this group of drugs differs in their cold and warm properties, they all share the same goal of clearing heat and detoxifying, softening and dispersing nodules, and jointly target the core pathogenesis of "toxic nodules," directly attacking the disease site. Furthermore, the addition of Platycodon grandiflorus, which is bitter, pungent, and neutral, specifically enters the lung meridian. It excels at opening and dispersing lung qi, eliminating phlegm and draining pus, and can also carry the medicine upward, guiding the power of other medicines directly to the lung system. Combined with licorice root, which descends, it achieves the wonderful effect of mutual promotion and demotion.

[0025] Furthermore, the preparation method of the traditional Chinese medicine composition for treating lung cancer includes the following steps: S1: Soaking: Add 10 times the amount of water to Codonopsis pilosula, Ophiopogon japonicus, Schisandra chinensis, Cornus officinalis, Polygonatum sibiricum, Taraxacum mongolicum, Hedyotis diffusa, Sparganium stoloniferum, Curcuma zedoaria, Taxus wallichiana, Citrus reticulata, Prunella vulgaris, Platycodon grandiflorus, Uncaria rhynchophylla, and Glycyrrhiza uralensis, and soak for 30 minutes. S2: Decoction: Heat to a boil and then keep simmering for 40 minutes. Pour out the decoction. Add 8 times the amount of water to the residue, heat to a boil and keep simmering for 40 minutes. Combine the two decoctions, filter, and collect the filtrate. S3: Concentration: Concentrate the above decoction using a rotary evaporator at 65°C and under reduced pressure until the concentration is 1.41 g / ml. Store at -20°C for later use.

[0026] The traditional Chinese medicine composition of this application has important clinical value in reducing toxicity and enhancing efficacy after chemotherapy / immunotherapy for lung cancer. The traditional Chinese medicine composition of this application will be referred to as the Qi-nourishing and Yin-tonifying formula. This formula attributes the pathogenesis of lung cancer to deficiency of vital energy and excess of pathogenic factors. It believes that lung cancer surgery or radiotherapy, chemotherapy, and targeted drug therapy often deplete Qi and Yin, and cause deficiency of the lung and spleen. Over time, this will damage the kidney Qi. Patients often present with fatigue, shortness of breath, chest tightness, which worsens after activity, cough with phlegm, and loss of appetite. The etiology can be summarized as "deficiency, phlegm, blood stasis, and toxin". Deficiency of Qi and Yin is the root cause, while phlegm stagnation, blood stasis, and toxin accumulation are the symptoms. Treatment should focus on strengthening the body's resistance and eliminating pathogenic factors, addressing both the root cause and the symptoms.

[0027] In the treatment of lung cancer, we should adhere to the principle of "eliminating without destroying" the pathogenic factors and focus on "reducing without attacking". The treatment should be based on tonifying qi and nourishing yin. We should not use large doses of products that disperse stagnation, break qi and deplete blood, or simply pile up anti-cancer and detoxifying drugs. Especially in patients with advanced lung cancer who have undergone radiotherapy, chemotherapy and targeted drug therapy, when they show signs of qi and yin deficiency and residual toxins, we should pay attention to supporting the body's vital energy and preserving the body for treatment.

[0028] Composed of five herbs—Codonopsis pilosula, Ophiopogon japonicus, Schisandra chinensis, Polygonatum sibiricum, and Cornus officinalis—this formula functions to invigorate qi and nourish yin, regulate and tonify the lungs and kidneys, and harmonize both. Treatment is modified according to different stages of cough and asthma, as well as accompanying symptoms, with satisfactory results. Subsequent use of this qi-invigorating and yin-nourishing formula, with modifications to include dandelion, Hedyotis diffusa, Sparganium stoloniferum, and Curcuma zedoaria (herbs that invigorate blood and dissipate nodules), combined with chemotherapy / targeted therapy, effectively improves adverse reactions and drug resistance in lung cancer patients, achieving a reduction in toxicity and enhancement of efficacy. Notably, the combination of this qi-invigorating and yin-nourishing formula with immunotherapy has significant clinical value in the treatment of lung cancer. Example 2

[0029] To investigate the synergistic effect of this compound on lung cancer immunotherapy, a currently recognized animal model of lung cancer was constructed. The experiment consisted of six groups: a lung cancer model group, a lung cancer model + low-dose compound intervention group (YQYY-L), a lung cancer model + medium-dose compound intervention group (YQYY-M), a lung cancer model + high-dose compound intervention group (YQYY-H), a lung cancer model + αPD-1 positive control group (PD-1), and a lung cancer model + high-dose compound combined with αPD-1 intervention group (YQYY-H+PD-1). The administration period was 15 days.

[0030] The results showed that the Qi-nourishing and Yin-tonifying formula did not have a significant inhibitory effect on lung cancer. Figure 1 The tumor volume shown, such as Figure 3 The tumor weight shown and as Figure 4 The tumor epigenetic results shown indicate that the combination of the drug and a PD-1 inhibitor significantly inhibited lung tumor growth compared to single-drug therapy. Notably, two mice in the combination group experienced complete tumor regression. Specific details of the tumor regression are as follows: Figure 2 shown.

[0031] like Figure 6 The blood routine results shown indicate that the combination of the compound and PD-1 inhibitor significantly increased lymphocyte levels and decreased neutrophil levels compared to the use of either alone. These results suggest that the combination of the Qi-nourishing and Yin-tonifying formula with PD-1 inhibitors has a significant synergistic anti-lung cancer effect.

[0032] At the same time, such as Figure 5 The organ coefficient results shown indicate that there were no significant differences in organ coefficients among the groups of mice, suggesting that the compound, PD-1 inhibitor alone, and combination therapy have good safety profiles.

Claims

1. A traditional Chinese medicine composition for treating lung cancer, characterized in that, The ingredients include: Codonopsis pilosula, Ophiopogon japonicus, Schisandra chinensis, Cornus officinalis, Polygonatum sibiricum, Taraxacum mongolicum, Hedyotis diffusa, Sparganium stoloniferum, Curcuma zedoaria, Taxus wallichiana, Citrus reticulata peel, Prunella vulgaris, Platycodon grandiflorus, Uncaria rhynchophylla, and Glycyrrhiza uralensis. The weight proportions of different raw materials are as follows: Codonopsis pilosula 15-60 parts, Ophiopogon japonicus 6-24 parts, Schisandra chinensis 3-12 parts, Cornus officinalis 6-24 parts, Polygonatum sibiricum 7-30 parts, Taraxacum mongolicum 7-30 parts, Hedyotis diffusa 15-60 parts, Sparganium stoloniferum 5-20 parts, Curcuma zedoaria 4-18 parts, Taxus wallichiana 1-6 parts, Citrus reticulata 5-20 parts, Prunella vulgaris 7-30 parts, Platycodon grandiflorus 5-20 parts, Uncaria rhynchophylla 15-60 parts, and Glycyrrhiza uralensis 5-20 parts.

2. The traditional Chinese medicine composition for treating lung cancer according to claim 1, characterized in that: The weight proportions of different raw materials are as follows: 30 parts of Codonopsis pilosula, 12 parts of Ophiopogon japonicus, 6 parts of Schisandra chinensis, 12 parts of Cornus officinalis, 15 parts of Polygonatum sibiricum, 15 parts of Taraxacum mongolicum, 30 parts of Hedyotis diffusa, 10 parts of Sparganium stoloniferum, 9 parts of Curcuma zedoaria, 3 parts of Taxus wallichiana, 10 parts of Citrus reticulata peel, 15 parts of Prunella vulgaris, 10 parts of Platycodon grandiflorus, 30 parts of Uncaria rhynchophylla, and 10 parts of Glycyrrhiza uralensis.

3. The method for preparing the traditional Chinese medicine composition according to claim 1 or 2, characterized in that: Includes the following steps: S1: Soaking: Add 10 times the amount of water to Codonopsis pilosula, Ophiopogon japonicus, Schisandra chinensis, Cornus officinalis, Polygonatum sibiricum, Taraxacum mongolicum, Hedyotis diffusa, Sparganium stoloniferum, Curcuma zedoaria, Taxus wallichiana, Citrus reticulata, Prunella vulgaris, Platycodon grandiflorus, Uncaria rhynchophylla, and Glycyrrhiza uralensis, and soak for 30 minutes. S2: Decoction: Heat to a boil and then keep simmering for 40 minutes. Pour out the decoction. Add 8 times the amount of water to the residue, heat to a boil and keep simmering for 40 minutes. Combine the two decoctions, filter, and collect the filtrate. S3: Concentration: Concentrate the above decoction using a rotary evaporator at 65°C and under reduced pressure until the concentration is 1.41 g / ml. Store at -20°C for later use.

4. A drug combination for treating lung cancer, characterized in that: The drug combination includes the traditional Chinese medicine composition as described in claim 1 or 2.

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