Granulation equipment and process for dextran iron sheets
Through integrated granulation equipment and processes, the automated mixing, extrusion, and cutting of dextran iron flakes have been achieved, solving the problem of insufficient automation in existing equipment and improving the convenience of granulation and product quality.
Patent Information
- Application Number
- CN202511349676.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-09-22
- Publication Date
- 2026-01-02
AI Technical Summary
Existing dextran iron flake granulation equipment is not integrated or automated enough, the granulation process is complex and requires a lot of manual operation, resulting in low convenience.
An integrated pelleting device was designed, including a tank, a stirring mechanism, an extrusion mechanism, and a cutting mechanism. The device achieves automated stirring, extrusion, and cutting through components such as a stirring motor, an electromagnetic control valve, an extrusion cylinder, and a cutting electric cylinder, and achieves precise cutting control by combining with a control unit.
It improves the automation level of the granulation process, reduces manual labor, increases the convenience of granulation, ensures uniform particle size and product quality, and reduces the intensity of manual operation.
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Figure CN121244085A_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The present application relates to the technical field of medicine granulation, in particular to a granulation equipment and process for dextran iron tablets. BACKGROUND
[0002] Iron is an essential trace element in the human body, which participates in various physiological processes. Iron deficiency or poor iron utilization can lead to metabolic disorders and cause diseases such as anemia.
[0003] Oral iron agents are the first choice for treating iron deficiency anemia, including oral preparations such as ferrous sulfate, ferrous lactate, fumarate, dextran iron, and succinate. Currently, the main iron injection agents on the market in China include sucrose iron, dextran iron, and sorbitol iron.
[0004] With the aging of the population, the number of elderly people among anemia patients will increase significantly in the future. At the same time, the country creates a good policy environment, and the health concept of the people is enhanced, so the future market of anti-anemia drugs will maintain stable growth. In recent years, the overall size of the hospital market for iron-containing preparations for anti-anemia drugs has continued to grow. Dextran iron tablets have a huge potential market.
[0005] As an important anti-anemia drug, the drug prescription and production process of dextran iron tablets are strictly designed and optimized. In terms of production process, first, ethanol solution is used as a binder, the amount of raw materials is calculated according to the iron content in the dextran iron raw material, and the amount of various auxiliary materials is calculated accordingly. Then, the raw and auxiliary materials are weighed and mixed according to the prescription amount to form a uniform soft material, which is then granulated, dried, and granulated. Then, magnesium stearate, sodium bicarbonate, and citric acid are mixed, and the intermediate content is detected before being pressed into tablets. Finally, the tablets are coated, packaged, and stored in the warehouse after passing the product inspection.
[0006] The existing manufacturing process of dextran iron tablets requires granulation, but the current granulation equipment is not integrated and automated enough, the granulation process is relatively complex, and manual operation is more common. In general, it is not convenient. SUMMARY
[0007] In order to at least solve one of the above technical problems, the purpose of the present application is to provide a granulation equipment and process for dextran iron tablets, which improves the degree of automation, reduces manual labor, and improves the convenience of granulation.
[0008] To achieve the above purpose, the present application provides the following technical solutions:
[0009] A granulating device for dextran iron tablets, comprising a tank body, main material pipes and auxiliary material pipes connected to both sides of the top of the tank body, the main material pipes being used for feeding dextran iron, the auxiliary material pipes being used for feeding auxiliary materials, a transverse partition plate arranged at the bottom of the tank body, the partition plate dividing the tank body into a stirring cavity at the top and an extruding cavity at the bottom, a stirring mechanism arranged at the axis of the stirring cavity, an automatic opening and closing mechanism arranged on the partition plate, an extruding mechanism arranged at one end of the extruding cavity, a discharge pipe arranged at the other end of the extruding cavity, a granulating screen arranged in the discharge pipe, and a cutting mechanism arranged on the side of the granulating screen away from the extruding cavity, the cutting mechanism being used for cutting the mixed materials extruded out of the granulating screen.
[0010] Preferably, the stirring mechanism comprises a stirring motor fixedly connected to the outer wall of the tank body, an output shaft of the stirring motor extending into the stirring cavity and fixedly connected with a stirring rod, and stirring blades arranged on the stirring rod.
[0011] Preferably, the automatic opening and closing mechanism is an electromagnetic control valve arranged on the side of the partition plate close to the extruding mechanism.
[0012] Preferably, the extruding mechanism comprises an extruding cylinder fixedly connected to the outer wall of the tank body, an output shaft of the extruding cylinder fixedly connected with an extruding plate, and the outer wall of the extruding plate being in sliding fit with the inner wall of the extruding cavity.
[0013] Preferably, the cutting mechanism comprises a cutting cylinder arranged outside the discharge pipe, a movable part of the cutting cylinder extending into the discharge pipe and fixedly connected with a cutting knife, the cross section of the discharge pipe being rectangular, and the cutting knife being in sliding connection with the inner wall of the discharge pipe on both sides.
[0014] Preferably, the device further comprises a control unit, the control unit being internally provided with a timer, and the control unit being used for controlling the extension and retraction period of the cutting cylinder according to the preset cutting interval through the timer.
[0015] A granulating process for dextran iron tablets, comprising the following steps:
[0016] (1) Feeding raw materials: feeding dextran iron raw materials into the stirring cavity of the tank body through the main material pipes, and feeding auxiliary materials into the stirring cavity through the auxiliary material pipes, wherein the auxiliary materials comprise one or more of sodium bicarbonate, low-substitution hydroxypropyl cellulose, microcrystalline cellulose, citric acid and magnesium stearate;
[0017] (2) Stirring and mixing: starting the stirring mechanism to fully stir and mix the dextran iron raw materials and the auxiliary materials in the stirring cavity to form uniform mixed materials;
[0018] (3) Extruding preparation: after the mixed materials are uniform, opening the automatic opening and closing mechanism to make the mixed materials in the stirring cavity fall into the extruding cavity;
[0019] (4) Extrusion granulation: start the extrusion mechanism to extrude the mixed material through the granulation screen in the discharge pipe to form strip-shaped particles;
[0020] (5) Cutting operation: during the extrusion of the mixed material through the granulation screen, the extruded strip-shaped particles are cut into particles of the desired length;
[0021] (6) Collect finished products: the cut particles are discharged from the discharge pipe and collected, completing the granulation process of iron dextran tablets.
[0022] The present application has the following beneficial effects:
[0023] I. Improve the degree of automation and reduce manual labor: The granulation equipment and process of the present application achieve high automation. In terms of equipment, the stirring mechanism automatically stirs through the stirring motor driving the stirring rod and stirring blades, without manual stirring; the automatic opening and closing mechanism uses an electromagnetic control valve to automatically control the on-off between the stirring cavity and the extrusion cavity; the extrusion mechanism automatically extrudes by relying on the extrusion cylinder driving the extrusion plate; the cutting mechanism automatically cuts the strip-shaped particles by relying on the cutting cylinder driving the cutting knife. In terms of process, the control unit has a built-in timer that automatically controls the extension and retraction cycle of the cutting cylinder according to the preset cutting interval, achieving automatic cutting. Most of the links in the entire granulation process, from stirring after raw material feeding, extrusion, cutting to finished product collection, are automatically completed by the equipment, reducing manual operation and labor intensity.
[0024] II. Improve the convenience of granulation: The granulation equipment has high integration, integrating stirring, extrusion, granulation, cutting and other functions on one tank body, with compact structure and small floor area. The process flow is relatively simple, and the operator only needs to follow the steps to feed the raw materials, and the subsequent stirring and mixing, extrusion and granulation processes will be automatically completed by the equipment, without complex operations and excessive process steps, improving the convenience of granulation.
[0025] III. Efficient connection of stirring and extrusion: After the stirring mechanism fully stirs and mixes the iron dextran raw materials and auxiliary materials to form uniform mixed material, the automatic opening and closing mechanism can be opened in time to allow the mixed material to fall smoothly into the extrusion cavity, and then the extrusion mechanism is quickly started for extrusion. This efficient connection of stirring and extrusion ensures the uniformity and continuity of the material during the granulation process, avoiding problems in granulation quality caused by uneven mixing of materials or poor connection.
[0026] Four, accurate cutting control: the cross section of the discharge pipe is rectangular, the cutting knife is slidably connected with the inner wall of the discharge pipe on both sides, and the extension and retraction period of the cutting cylinder is controlled by the control unit according to the preset cutting interval, so that the extruded strip-shaped particles can be accurately cut into particles of the required length. This accurate cutting control method makes the size of the prepared particles uniform, meets the quality requirements of iron dextran tablets, and improves the qualified rate of the product.
[0027] Five, flexible collocation of various excipients: in the granulation process, the excipients include one or more of sodium bicarbonate, low-substituted hydroxypropyl cellulose, microcrystalline cellulose, citric acid and magnesium stearate. The selection and flexible collocation of the various excipients can be adjusted according to the different performance requirements and production process requirements of iron dextran tablets, which helps to optimize the quality and performance of iron dextran tablets. BRIEF DESCRIPTION OF DRAWINGS
[0028] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the following will briefly introduce the drawings needed to be used in the embodiments. It should be understood that the following drawings only show some embodiments of the present application, and therefore should not be regarded as a limitation on the scope. For those skilled in the art, other related drawings can also be obtained without creative labor.
[0029] Fig. 1 The sectional view of the embodiment of the present application.
[0030] Fig. 2 The sectional view of the discharge pipe of the embodiment of the present application.
[0031] In the figure: 1, tank body; 101, main pipe; 102, auxiliary pipe; 103, isolation plate; 104, discharge pipe; 105, granulation screen; 201, stirring motor; 202, stirring rod; 203, stirring blade; 3, electromagnetic control valve; 401, extrusion cylinder; 402, extrusion plate; 501, cutting cylinder; 502, cutting knife; 503, control unit. DETAILED DESCRIPTION
[0032] The technical solutions in the embodiments of the present application will be described clearly and completely below in combination with the drawings in the embodiments of the present application. Obviously, the described embodiments are only some of the embodiments of the present application, not all. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor are within the scope of protection of the present application.
[0033] As Figs. 1-2As shown, a granulation device for dextran iron flakes includes a tank 1. A main feed pipe 101 and an auxiliary feed pipe 102 are connected to the top two sides of the tank 1, respectively. The main feed pipe 101 is used to feed dextran iron, and the auxiliary feed pipe 102 is used to feed auxiliary materials. A horizontally placed partition plate 103 is provided at the bottom of the tank 1, which divides the interior of the tank 1 into an upper stirring chamber and a lower extrusion chamber. A stirring mechanism is provided at the central axis of the stirring chamber. An automatic opening and closing mechanism is provided on the partition plate 103. An extrusion mechanism is provided at one end of the extrusion chamber, and a discharge pipe 104 is provided at the other end of the extrusion chamber. A granulation screen 105 is provided inside the discharge pipe 104. A cutting mechanism is provided on the side of the granulation screen 105 away from the extrusion chamber. The cutting mechanism is used to cut off the mixture extruded from the granulation screen 105.
[0034] like Figs. 1-2 As shown, dextran iron raw material and auxiliary materials (such as sodium bicarbonate, low-substituted hydroxypropyl cellulose, microcrystalline cellulose, citric acid, magnesium stearate, or one or more of these) are fed into the mixing chamber inside the tank 1 through the main material pipe 101 and auxiliary material pipe 102 on both sides of the top of the tank 1. The stirring mechanism set at the central axis of the mixing chamber starts to work. The stirring motor 201 drives the output shaft to rotate, which in turn causes the stirring rod 202 fixed on the output shaft and the stirring fan blade 203 on the stirring rod 202 to rotate, fully stirring the dextran iron raw material and auxiliary materials in the mixing chamber, so that they are evenly mixed to form a mixture. After the raw material and auxiliary materials in the mixing chamber are evenly mixed, the automatic opening and closing mechanism (electromagnetic control valve 3) on the isolation plate 103 is opened, and the mixing chamber, which was originally blocked by the isolation plate 103, is connected to the extrusion chamber. The evenly mixed material in the mixing chamber falls into the extrusion chamber below under the action of gravity. The extrusion mechanism at one end of the extrusion chamber begins operation. The output shaft of the extrusion cylinder 401 extends, pushing the extrusion plate 402, which is fixedly connected to the output shaft, to slide within the extrusion chamber. Because the outer wall of the extrusion plate 402 slides against the inner wall of the extrusion chamber, the extrusion plate 402 applies pressure to the mixture within the extrusion chamber, causing the mixture to be extruded through the granulation screen 105 in the discharge pipe 104 at the other end of the extrusion chamber, forming strip-shaped particles. The aperture of the granulation screen 105 determines the thickness of the strip-shaped particles. During the process of the mixture being extruded through the granulation screen 105 to form strip-shaped particles, the material-cutting mechanism located on the side of the granulation screen 105 away from the extrusion chamber (i.e., inside the discharge pipe 104) begins operation. Under the control of the control unit 503 (which has a built-in timer to control the extension and retraction cycle of the cutting cylinder 501 according to a preset cutting interval), the movable part of the cutting cylinder 501 extends and retracts at set time intervals, driving the cutting blade 502 fixed on the movable part to reciprocate within the discharge pipe 104. Since the cross-section of the discharge pipe 104 is rectangular, the two sides of the cutting blade 502 are slidably connected to the inner wall of the discharge pipe 104, thereby cutting the extruded strip-shaped granules into granules of the required length. The cut granules are discharged from the discharge pipe 104 and collected by the operator, thus completing the granulation process of dextran iron flakes.
[0035] As shown in Figs. 1-2 , the stirring mechanism includes a stirring motor 201 fixedly connected with the outer wall of the tank body 1, the output shaft of the stirring motor 201 extends into the stirring cavity and is fixedly connected with a stirring rod 202, and the stirring rod 202 is provided with stirring blades 203. The stirring motor is fixedly connected with the outer wall of the tank body 1, and when the stirring motor 201 is started, the output shaft begins to rotate. Since the output shaft extends into the stirring cavity and is fixedly connected with the stirring rod 202, it will drive the stirring rod 202 to rotate. The stirring rod 202 is provided with stirring blades 203, and the rotation of the stirring rod 202 makes the stirring blades 203 make a circular motion in the stirring cavity, thereby stirring the iron dextran raw materials and auxiliary materials in the stirring cavity and making them fully mixed and uniform, forming a mixture suitable for subsequent granulation.
[0036] As shown in Figs. 1-2 , the automatic opening and closing mechanism is an electromagnetic control valve 3, which is arranged on the side of the isolation plate 103 close to the extruding mechanism. In the initial state, the electromagnetic control valve 3 is in a closed state, separating the stirring cavity and the extruding cavity, preventing the mixture in the stirring cavity from falling into the extruding cavity in advance. When the raw materials and auxiliary materials in the stirring cavity are fully mixed, the electromagnetic control valve 3 is powered, and the electromagnetic force moves the valve core to open the valve. At this time, the stirring cavity is communicated with the extruding cavity, and the mixture falls from the stirring cavity to the extruding cavity under the action of gravity. After the material is finished, the power supply of the electromagnetic control valve 3 is cut off, and the valve is closed under the action of the reset device such as spring, preventing the material in the extruding cavity from flowing back.
[0037] As shown in Figs. 1-2 , the extruding mechanism includes an extrusion cylinder 401 fixedly connected with the outer wall of the tank body 1, and the output shaft of the extrusion cylinder 401 is fixedly connected with an extrusion plate 402, and the outer wall of the extrusion plate 402 is in sliding fit with the inner wall of the extruding cavity. The extrusion cylinder 401 is fixedly connected with the outer wall of the tank body 1, and when the extrusion cylinder 401 is started, the output shaft will make a linear extension and retraction motion. Because the output shaft is fixedly connected with the extrusion plate 402, it will drive the extrusion plate 402 to slide linearly in the extruding cavity. Because the outer wall of the extrusion plate 402 is in sliding fit with the inner wall of the extruding cavity, the extrusion plate 402 will apply pressure to the mixture in the extruding cavity during movement, extruding the mixture towards the discharge pipe 104, so that the mixture is extruded through the granulating screen 105 in the discharge pipe 104, forming strip-shaped particles.
[0038] As shown in Figs. 1-2As shown, the material cutting mechanism includes a cutting cylinder 501 disposed outside the discharge pipe 104. The movable part of the cutting cylinder 501 extends into the discharge pipe 104 and is fixedly connected to a cutting blade 502. The cross-section of the discharge pipe 104 is rectangular, and the two sides of the cutting blade 502 are slidably connected to the inner wall of the discharge pipe 104. The cutting cylinder 501 is disposed outside the discharge pipe 104, and its movable part extends into the discharge pipe 104 and is fixedly connected to the cutting blade 502. The rectangular cross-section of the discharge pipe 104 and the slidable connection between the two sides of the cutting blade 502 and the inner wall of the discharge pipe 104 allow the cutting blade 502 to only reciprocate linearly along the length of the discharge pipe 104 under the drive of the cutting cylinder 501. When the mixture is extruded through the granulation screen 105 to form strip-shaped particles, the control unit 503 controls the extension and retraction cycle of the cutting cylinder 501 through a timer according to a preset cutting interval. When the movable part of the cutting cylinder 501 extends, it drives the cutting blade 502 to move forward and cut the extruded strip-shaped particles; when the movable part retracts, the cutting blade 502 returns to its initial position, waiting for the next cut, thereby obtaining particles of the required length.
[0039] like Figs. 1-2 As shown, the system also includes a control unit 503, which has a built-in timer. The control unit 503 controls the extension and retraction cycle of the cutting electric cylinder 501 based on the timer and a preset cutting interval. The built-in timer in the control unit 503 can accurately record time. The operator presets the cutting interval in the control unit 503 according to the requirements of dextran iron sheet granulation. During the granulation process, the timer starts counting. When the preset cutting interval is reached, the control unit 503 sends a control signal to the cutting electric cylinder 501 to control the extension and retraction of the cutting electric cylinder 501, thereby controlling the cutting cycle of the cutting blade 502, achieving automatic and precise material cutting operation.
[0040] During installation, a professional coupling is used to connect the output shaft of the stirring motor 201 to the stirring rod 202. A dynamic balancing test is performed after installation to ensure smooth operation of the stirring mechanism. Simultaneously, the angle and number of the stirring blades 203 are adjusted appropriately according to the characteristics of the material and the stirring requirements to achieve the best stirring effect.
[0041] A high-precision electromagnetic control valve 3 is selected and equipped with a dedicated control system to precisely set and adjust the opening and closing times of the electromagnetic control valve 3. During the equipment commissioning phase, multiple simulated runs are conducted to observe the material flow and optimize the control parameters based on the actual situation.
[0042] According to the quality requirements and production process of dextran iron tablets, a suitable aperture of the granulating screen 105 is selected, and a certain number of standby screens are prepared. The structure of the equipment is designed to facilitate the disassembly and installation of the granulating screen 105, and the operator can quickly complete the replacement of the granulating screen 105 according to the guidance of the operation manual. At the same time, the granulating screen 105 is cleaned and inspected regularly, and the wear or blockage problems are found and handled in time.
[0043] The above is only a specific embodiment of the present application, but the technical features of the present application are not limited thereto. Any simple change, equivalent replacement or modification made on the basis of the present application to solve the basically same technical problem and achieve the basically same technical effect is covered within the protection scope of the present application.
Claims
1. A granulation device for dextran iron flakes, comprising a tank (1), characterized in that, The tank body (1) is connected to a main material pipe (101) and an auxiliary material pipe (102) on the top two sides respectively. The main material pipe (101) is used to add dextran iron, and the auxiliary material pipe (102) is used to add auxiliary materials. The bottom of the tank body (1) is provided with a horizontally placed partition plate (103). The partition plate (103) divides the interior of the tank body (1) into an upper stirring chamber and a lower extrusion chamber. A stirring mechanism is provided at the central axis of the stirring chamber. An automatic opening and closing mechanism is provided on the partition plate (103). An extrusion mechanism is provided at one end of the extrusion chamber, and a discharge pipe (104) is provided at the other end of the extrusion chamber. A granulation screen (105) is provided inside the discharge pipe (104). A cutting mechanism is provided on the side of the granulation screen (105) away from the extrusion chamber. The cutting mechanism is used to cut off the mixture that is extruded from the granulation screen (105).
2. The granulation equipment for dextran iron tablets according to claim 1, characterized in that, The stirring mechanism includes a stirring motor (201) fixedly connected to the outer wall of the tank (1). The output shaft of the stirring motor (201) extends into the stirring chamber and is fixedly connected to a stirring rod (202). The stirring rod (202) is provided with stirring blades (203).
3. The granulation equipment for dextran iron tablets according to claim 1, characterized in that, The automatic opening and closing mechanism is an electromagnetic control valve (3), which is located on the side of the isolation plate (103) near the extrusion mechanism.
4. The granulation equipment for dextran iron tablets according to claim 1, characterized in that, The extrusion mechanism includes an extrusion cylinder (401) fixedly connected to the outer wall of the tank (1). The output shaft of the extrusion cylinder (401) is fixedly connected to an extrusion plate (402). The outer wall of the extrusion plate (402) slides against the inner wall of the extrusion chamber.
5. A granulation device for dextran iron tablets according to claim 1, characterized in that, The material cutting mechanism includes a cutting electric cylinder (501) disposed outside the discharge pipe (104). The movable part of the cutting electric cylinder (501) extends into the discharge pipe (104) and is fixedly connected to a cutting blade (502). The cross-section of the discharge pipe (104) is rectangular, and the two sides of the cutting blade (502) are slidably connected to the inner wall of the discharge pipe (104).
6. A granulation device for dextran iron tablets according to claim 5, characterized in that, It also includes a control unit (503), which has a built-in timer. The control unit (503) controls the extension and retraction cycle of the cutting electric cylinder (501) through the timer and according to the preset cutting interval.
7. A granulation process for dextran iron tablets, using the granulation equipment for dextran iron tablets as described in any one of claims 1 to 6, characterized in that: Includes the following steps: (1) Raw material feeding: Dextran iron raw material is fed into the stirring chamber of the tank (1) through the main material pipe (101), and auxiliary materials are fed into the stirring chamber through the auxiliary material pipe (102). The auxiliary materials include one or more of sodium bicarbonate, low-substituted hydroxypropyl cellulose, microcrystalline cellulose, citric acid, and magnesium stearate. (2) Stirring and mixing: Start the stirring mechanism to fully stir and mix the dextran iron raw material and auxiliary materials in the stirring chamber to form a uniform mixture; (3) Extrusion preparation: After the mixture is evenly mixed, the automatic opening and closing mechanism is turned on so that the mixture in the mixing chamber falls into the extrusion chamber; (4) Extrusion granulation: Start the extrusion mechanism to make the mixture be extruded through the granulation screen (105) in the discharge pipe (104) to form strip-shaped granules; (5) Cutting operation: During the process of the mixture being extruded through the granulation screen (105), the extruded strip particles are cut into particles of the required length; (6) Collect the finished product: The cut granules are discharged from the discharge pipe (104) and collected to complete the granulation process of dextran iron tablets.