Targeted phlegm clearing combustion type chronic obstructive pulmonary disease traditional Chinese medicine fumigant and preparation process thereof
The targeted expectorant and combustible COPD fumigant, prepared by optimizing the manufacturing process, solves the problems of slow onset and complicated operation of traditional Chinese medicine in the treatment of COPD. It achieves long-lasting and stable efficacy and high release of components, thus improving the treatment effect and ease of use.
Patent Information
- Application Number
- CN202511547059.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-10-28
- Publication Date
- 2026-01-09
AI Technical Summary
Existing methods of treating COPD with traditional Chinese medicine have drawbacks such as slow onset of action, poor patient compliance, and complex operation of traditional external treatments requiring specific equipment, which limits their application in homes and primary healthcare units.
This product is a targeted expectorant for COPD using a combustible Chinese herbal fumigant. It contains a specific Chinese herbal formula and an optimized preparation process, including steps such as herbal pretreatment, mixing and pulverizing, adding combustion aids and granulation and drying, to produce columnar bodies with a diameter of 3-5 mm and a length of 8-12 mm. After ultraviolet sterilization, it is packaged.
It achieves sustained stability of drug efficacy and high release rate of active ingredients, improves treatment effectiveness and ease of use, reduces the risk of infection, and provides a safe and effective treatment option.
Abstract
Description
Technical Field
[0001] This invention relates to the field of traditional Chinese medicine technology, and in particular to a targeted expectorant, combustible COPD traditional Chinese medicine fumigant and its preparation process. Background Technology
[0002] In the field of traditional Chinese medicine, chronic obstructive pulmonary disease (COPD), as a common respiratory disease, has always received much attention for its treatment. COPD patients often experience symptoms such as increased sputum production and thick, difficult-to-cough sputum, which seriously affects their quality of life and respiratory function. Traditional Chinese medicine treatments often involve oral decoctions or pills, which can alleviate symptoms to some extent, but suffer from slow onset of action and poor patient compliance. This is especially inconvenient for elderly or frail patients who require long-term consumption of large amounts of decoctions.
[0003] In addition, existing external treatments of traditional Chinese medicine, such as nebulized inhalation and herbal patches, can act directly on the respiratory tract, but they are complicated to operate and require specific equipment or conditions, which limits their application in homes or primary healthcare units. Summary of the Invention
[0004] The purpose of this invention is to address the shortcomings of existing technologies by proposing a targeted expectorant-clearing combustible COPD herbal fumigant and its preparation process.
[0005] To achieve the above objectives, the present invention adopts the following technical solution: A targeted expectorant combustible COPD herbal fumigant: The herbal formula of the fumigant includes Platycodon grandiflorus, Fritillaria cirrhosa, Perilla frutescens, Tussilago farfara, Prunus armeniaca, Stemona japonica, and Glycyrrhiza uralensis.
[0006] Preferably, the traditional Chinese medicine formula, by weight, is as follows: Platycodon grandiflorus 15-25g, Fritillaria cirrhosa 8-12g, Perilla frutescens 12-18g, Tussilago farfara 10-15g, Prunus armeniaca 10-15g, Stemona japonica 12-18g, Glycyrrhiza uralensis 5-10g.
[0007] Preferably, the Fritillaria cirrhosa is selected from Fritillaria thunbergii or Fritillaria cirrhosa, and the Fritillaria cirrhosa is used after removing impurities and grinding into coarse powder.
[0008] Preferably, the process includes the following steps: S1. Pretreatment of medicinal materials; S2. Mix and pulverize the pretreated medicinal materials according to the preset weight proportions; S3. Add combustion aid to the pulverized mixture and stir evenly; S4. Add a wetting agent to the material containing the combustion aid and granulate it; S5. Dry and shape the wet granules; S6. After drying, the granules are shaped, sterilized, and then packaged.
[0009] Preferably, the pretreatment of medicinal materials in step S1 includes: Platycodon grandiflorus, perilla seed, and apricot kernel were baked at a low temperature of 60-70℃ for 1-1.5 hours; Fritillaria cirrhosa, coltsfoot flower, and Stemona japonica were vacuum dried at 50-55℃ for 2-2.5 hours; and licorice was sliced to a thickness of 1-2 mm.
[0010] Preferably, in step S2, the fineness of the pulverized mixture is such that it passes through an 80-100 mesh sieve; In step S3, the combustion aid is a mixture of sodium carboxymethyl cellulose and kaolin, with a mass ratio of 1:2-3, and the amount of combustion aid added is 3-5% of the total weight of the mixture.
[0011] Preferably, in step S4, the wetting agent is ethanol with a volume concentration of 70-80%; in step S5, the drying temperature is 55-60℃, and the moisture content of the dried particles is ≤3%; in step S6, the particles are formed into columnar bodies with a diameter of 3-5mm and a length of 8-12mm, and the sterilization method is ultraviolet sterilization for 20-30 minutes.
[0012] The present invention proposes a targeted expectorant combustion-type COPD traditional Chinese medicine fumigant and its preparation process, which has the following beneficial effects: long-lasting and stable efficacy: Fritillaria cirrhosa or Fritillaria tangutorum is selected as the source of Fritillaria cirrhosa. There is no significant difference between the two in terms of expectorant effect, but Fritillaria cirrhosa is slightly better in terms of efficacy duration, which helps to prolong the drug action time and improve the therapeutic effect. Detailed Implementation
[0013] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Example
[0014] A targeted expectorant for COPD using traditional Chinese medicine fumigation, wherein the herbal formula of the fumigation includes Platycodon grandiflorus, Fritillaria cirrhosa, Perilla frutescens, Tussilago farfara, Prunus armeniaca, Stemona japonica, and Glycyrrhiza uralensis.
[0015] The Chinese herbal formula, by weight, is as follows: Platycodon grandiflorus 25g, Fritillaria cirrhosa 12g, Perilla frutescens 18g, Tussilago farfara 15g, Prunus armeniaca 15g, Stemona japonica 18g, Glycyrrhiza uralensis 10g.
[0016] Fritillaria cirrhosa is either Fritillaria thunbergii or Fritillaria cirrhosa, and is used after removing impurities and grinding into coarse powder.
[0017] There was no significant difference in the expectorant effect between Fritillaria cirrhosa and Fritillaria thunbergii (p>0.05), but Fritillaria cirrhosa was slightly better than Fritillaria thunbergii in terms of the duration of its efficacy.
[0018] A preparation process for a targeted expectorant-clearing combustible COPD traditional Chinese medicine fumigation agent includes the following steps: S1. Pre-treatment of medicinal materials: Platycodon grandiflorus, perilla seeds, and almonds were subjected to low-temperature baking treatment at 70℃ for 1.5 hours.
[0019] Under these conditions, the retention rate of effective components in medicinal materials can reach over 90%.
[0020] Fritillaria cirrhosa, Tussilago farfara, and Stemona japonica were vacuum dried at 55°C for 2.5 hours.
[0021] Under these conditions, the moisture content of the medicinal materials can be reduced to below 5%, which is beneficial for subsequent crushing and mixing.
[0022] The licorice was sliced to a thickness of 2 mm.
[0023] If the slices are too thick, the active ingredients will not be extracted sufficiently; if they are too thin, they will break easily.
[0024] S2, Mixing and grinding: The platycodon, fritillaria, perilla seed, coltsfoot flower, apricot kernel, stemona root and licorice root, which have been pretreated by S1, are mixed according to the preset weight parts and then pulverized into a mixed powder.
[0025] The fineness of the mixed powder is such that it passes through a 100-mesh sieve.
[0026] At this fineness, the release rate of active ingredients in medicinal materials is the highest, reaching over 85%.
[0027] S3. Add combustion aids: Add a combustion aid to the mixed powder obtained in S2 and stir until it is evenly dispersed to form the material to be granulated.
[0028] The combustion aid is a mixture of sodium carboxymethyl cellulose and kaolin, with a mass ratio of 3, and the amount of combustion aid added is 5% of the total weight of the mixed powder.
[0029] At this ratio, the smoke agent burns at a moderate rate, and the combustion completeness can reach over 95%.
[0030] S4. Granulation process: Add a wetting agent to the material to be granulated and use a granulator to form wet granules.
[0031] The wetting agent is ethanol with a volume concentration of 80%. The amount of ethanol added is such that the material to be granulated can be formed into a clump when squeezed in the hand and dispersed when lightly touched.
[0032] Experimental data show that the particles prepared at this concentration have moderate hardness and are not easily broken.
[0033] S5. Drying and shaping: The wet granules obtained from S4 are placed in a drying device for drying, and the moisture content of the granules is controlled.
[0034] The drying temperature is 60℃, and the moisture content of the dried particles is ≤3%. Under these conditions, the stability and combustibility of the particles are optimal.
[0035] S6. Molded Packaging: The dried granules are pressed into cylindrical bodies of a predetermined size, with a diameter of 5 mm and a length of 12 mm. This size makes the fumigant convenient to use and less likely to extinguish.
[0036] After UV sterilization, the products are individually packaged for 20-30 minutes. Experiments have shown that this sterilization process effectively kills microorganisms on the surface of the packaging materials, ensuring the hygienic quality of the product.
[0037] High retention rate of active ingredients: By low-temperature baking of Platycodon grandiflorus, Perilla frutescens, and apricot kernels, the retention rate of active ingredients can reach more than 90%, ensuring the maximum utilization of active ingredients in medicinal materials.
[0038] Long-lasting and stable efficacy: Using either Fritillaria cirrhosa or Fritillaria thunbergii as the source of Fritillaria cirrhosa, there is no significant difference in the expectorant effect between the two, but Fritillaria cirrhosa has a slightly better long-lasting efficacy, which helps to prolong the duration of drug action and improve the therapeutic effect.
[0039] Excellent combustion performance: By adding a specific proportion of combustion aid (sodium carboxymethyl cellulose to kaolin in a mass ratio of 1:2-3) and controlling the amount added to 3-5% of the total weight of the mixed powder, the smoke agent has a moderate combustion speed and a combustion completeness of over 95%, effectively solving the problem of incomplete combustion of traditional smoke agents.
[0040] High release rate of active ingredients: The fineness of the mixed powder is 80-100 mesh, which is the highest release rate of active ingredients of the medicinal materials, reaching more than 85%, which significantly improves the local concentration of the drug in the respiratory tract and enhances the therapeutic effect.
[0041] Convenient and safe to use: The dried granules are compressed into cylindrical shapes with a diameter of 3mm and a length of 8mm, which is convenient for patients to use and is not easy to extinguish, thus improving treatment compliance.
[0042] Meanwhile, after being sterilized by ultraviolet light for 20 minutes, the products are individually packaged, which effectively kills microorganisms on the surface of the packaging materials, ensuring the hygiene and quality of the products and reducing the risk of infection.
[0043] The targeted expectorant and combustion-type COPD traditional Chinese medicine fumigant of the present invention achieves high retention rate, high release rate and excellent combustion performance of effective ingredients by optimizing key process steps such as herbal pretreatment, mixing and pulverizing, adding combustion aids, granulation and drying, providing a safe, effective and convenient new treatment option for COPD patients. Example
[0044] The difference between this embodiment and Embodiment 1 is that the traditional Chinese medicine formula of the fumigant includes Platycodon grandiflorus, Fritillaria cirrhosa, Perilla frutescens, Tussilago farfara, Prunus armeniaca, Stemona japonica, and Glycyrrhiza uralensis.
[0045] The Chinese herbal formula, by weight, is as follows: Platycodon grandiflorus 25g, Fritillaria cirrhosa 12g, Perilla frutescens 18g, Tussilago farfara 15g, Prunus armeniaca 15g, Stemona japonica 18g, Glycyrrhiza uralensis 10g.
[0046] Fritillaria cirrhosa is either Fritillaria thunbergii or Fritillaria cirrhosa, and is used after removing impurities and grinding into coarse powder.
[0047] There was no significant difference in the expectorant effect between Fritillaria cirrhosa and Fritillaria thunbergii (p>0.05), but Fritillaria cirrhosa was slightly better than Fritillaria thunbergii in terms of the duration of its efficacy.
[0048] A preparation process for a targeted expectorant-clearing combustible COPD traditional Chinese medicine fumigation agent includes the following steps: S1. Pre-treatment of medicinal materials: Platycodon grandiflorus, perilla seeds, and almonds were subjected to low-temperature baking treatment at 70℃ for 1.5 hours.
[0049] Under these conditions, the retention rate of effective components in medicinal materials can reach over 90%.
[0050] Fritillaria cirrhosa, Tussilago farfara, and Stemona japonica were vacuum dried at 55°C for 2.5 hours.
[0051] Under these conditions, the moisture content of the medicinal materials can be reduced to below 5%, which is beneficial for subsequent crushing and mixing.
[0052] The licorice was sliced to a thickness of 2 mm.
[0053] If the slices are too thick, the active ingredients will not be extracted sufficiently; if they are too thin, they will break easily.
[0054] S2, Mixing and grinding: The platycodon, fritillaria, perilla seed, coltsfoot flower, apricot kernel, stemona root and licorice root, which have been pretreated by S1, are mixed according to the preset weight parts and then pulverized into a mixed powder.
[0055] The fineness of the mixed powder is such that it passes through a 100-mesh sieve.
[0056] At this fineness, the release rate of active ingredients in medicinal materials is the highest, reaching over 85%.
[0057] S3. Add combustion aids: Add a combustion aid to the mixed powder obtained in S2 and stir until it is evenly dispersed to form the material to be granulated.
[0058] The combustion aid is a mixture of sodium carboxymethyl cellulose and kaolin, with a mass ratio of 3, and the amount of combustion aid added is 5% of the total weight of the mixed powder.
[0059] At this ratio, the smoke agent burns at a moderate rate, and the combustion completeness can reach over 95%.
[0060] S4. Granulation process: Add a wetting agent to the material to be granulated and use a granulator to form wet granules.
[0061] The wetting agent is ethanol with a volume concentration of 80%. The amount of ethanol added is such that the material to be granulated can be formed into a clump when squeezed in the hand and dispersed when lightly touched.
[0062] Experimental data show that the particles prepared at this concentration have moderate hardness and are not easily broken.
[0063] S5. Drying and shaping: The wet granules obtained from S4 are placed in a drying device for drying, and the moisture content of the granules is controlled.
[0064] The drying temperature is 60℃, and the moisture content of the dried particles is ≤3%. Under these conditions, the stability and combustibility of the particles are optimal.
[0065] S6. Molded Packaging: The dried granules are pressed into cylindrical bodies of a predetermined size, with a diameter of 5 mm and a length of 12 mm. This size makes the fumigant convenient to use and less likely to extinguish.
[0066] After UV sterilization, the products are individually packaged for 30 minutes. Experiments have shown that this sterilization process effectively kills microorganisms on the surface of the packaging materials, ensuring the hygienic quality of the product.
[0067] High retention rate of active ingredients: By low-temperature baking of Platycodon grandiflorus, Perilla frutescens, and apricot kernels, the retention rate of active ingredients can reach more than 90%, ensuring the maximum utilization of active ingredients in medicinal materials.
[0068] Long-lasting and stable efficacy: Using either Fritillaria cirrhosa or Fritillaria thunbergii as the source of Fritillaria cirrhosa, there is no significant difference in the expectorant effect between the two, but Fritillaria cirrhosa has a slightly better long-lasting efficacy, which helps to prolong the duration of drug action and improve the therapeutic effect.
[0069] Excellent combustion performance: By adding a specific proportion of combustion aid (sodium carboxymethyl cellulose to kaolin in a mass ratio of 1:2-3) and controlling the amount added to 3-5% of the total weight of the mixed powder, the smoke agent has a moderate combustion speed and a combustion completeness of over 95%, effectively solving the problem of incomplete combustion of traditional smoke agents.
[0070] High release rate of active ingredients: The fineness of the mixed powder is 100 mesh, which is the highest release rate of active ingredients of the medicinal materials, reaching more than 85%, which significantly improves the local concentration of the drug in the respiratory tract and enhances the therapeutic effect.
[0071] Convenient and safe to use: The dried granules are compressed into cylindrical shapes with a diameter of 5mm and a length of 12mm, which is convenient for patients to use and is not easy to extinguish, thus improving treatment compliance.
[0072] Meanwhile, after being sterilized by ultraviolet light for 30 minutes, the products are individually packaged, which effectively kills microorganisms on the surface of the packaging materials, ensuring the hygienic quality of the products and reducing the risk of infection.
[0073] The targeted expectorant and combustion-type COPD traditional Chinese medicine fumigant of the present invention achieves high retention rate, high release rate and excellent combustion performance of effective ingredients by optimizing key process steps such as herbal pretreatment, mixing and pulverizing, adding combustion aids, granulation and drying, providing a safe, effective and convenient new treatment option for COPD patients.
[0074] The above description is only a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any equivalent substitutions or modifications made by those skilled in the art within the scope of the technology disclosed in the present invention, based on the technical solution and inventive concept of the present invention, should be covered within the scope of protection of the present invention.
Claims
1. A targeted expectorant-clearing combustible traditional Chinese medicine fumigant for COPD, characterized in that: The herbal formula of the fumigant includes Platycodon grandiflorus, Fritillaria cirrhosa, Perilla frutescens, Tussilago farfara, Prunus armeniaca, Stemona japonica, and Glycyrrhiza uralensis.
2. The targeted expectorant combustible COPD traditional Chinese medicine fumigation agent according to claim 1, characterized in that: The herbal formula, by weight, consists of: Platycodon grandiflorus 15-25g, Fritillaria cirrhosa 8-12g, Perilla frutescens 12-18g, Tussilago farfara 10-15g, Prunus armeniaca 10-15g, Stemona japonica 12-18g, and Glycyrrhiza uralensis 5-10g.
3. The targeted expectorant combustible COPD traditional Chinese medicine fumigation agent according to claim 1, characterized in that: The fritillaria cirrhosa is selected from fritillaria thunbergii or fritillaria cirrhosa, and the fritillaria cirrhosa is used after removing impurities and grinding into coarse powder.
4. A preparation process for a targeted expectorant combustible COPD traditional Chinese medicine fumigation agent according to any one of claims 1-3, characterized in that: The process includes the following steps: S1. Pretreatment of medicinal materials; S2. Mix and pulverize the pretreated medicinal materials according to the preset weight proportions; S3. Add combustion aid to the pulverized mixture and stir evenly; S4. Add a wetting agent to the material containing the combustion aid and granulate it; S5. Dry and shape the wet granules; S6. After drying, the granules are shaped, sterilized, and then packaged.
5. The preparation process of the targeted expectorant combustible COPD traditional Chinese medicine fumigation agent according to claim 4, characterized in that: The pretreatment of medicinal materials in step S1 includes: Platycodon grandiflorus, perilla seed, and apricot kernel were baked at a low temperature of 60-70℃ for 1-1.5 hours; Fritillaria cirrhosa, coltsfoot flower, and Stemona japonica were vacuum dried at 50-55℃ for 2-2.5 hours; and licorice was sliced to a thickness of 1-2 mm.
6. The preparation process of the targeted expectorant combustible COPD traditional Chinese medicine fumigation agent according to claim 4, characterized in that: In step S2, the fineness of the mixture after pulverization is such that it passes through an 80-100 mesh sieve; In step S3, the combustion aid is a mixture of sodium carboxymethyl cellulose and kaolin, with a mass ratio of 1:2-3, and the amount of combustion aid added is 3-5% of the total weight of the mixture.
7. The preparation process of the targeted expectorant combustible COPD traditional Chinese medicine fumigation agent according to claim 4, characterized in that: In step S4, the wetting agent is ethanol with a volume concentration of 70-80%; in step S5, the drying temperature is 55-60℃, and the moisture content of the dried particles is ≤3%; in step S6, the particles are formed into columnar bodies with a diameter of 3-5mm and a length of 8-12mm, and the sterilization method is ultraviolet sterilization for 20-30 minutes.