Use of polysialic acid or a derivative thereof in an anti-foreign body reaction

Hydrogels or coatings prepared using polysialic acid or its derivatives have solved the problem of foreign body reactions caused by biomaterials in vivo, achieving effective anti-protein adsorption and inflammation regulation, and providing excellent anti-foreign body reaction effects.

CN121288006BActive Publication Date: 2026-03-27EAST CHINA UNIV OF SCI & TECH
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Patent Information

Application Number
CN202511884156.5
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-12-15
Publication Date
2026-03-27
Estimated Expiration
2045-12-15

AI Technical Summary

Technical Problem

Existing biomaterials are prone to triggering foreign body response (FBR) when implanted in the body, leading to inflammation and fibrosis. Existing strategies such as surface modification and drug coating have stability and toxicity issues, and it is difficult to achieve both anti-protein adsorption and immunomodulatory functions.

Method used

Hydrogels or coatings made from polysialic acid or its derivatives can inhibit protein adsorption, regulate macrophage phenotype, and reduce inflammatory responses through their negative charge and immunomodulatory functions.

Benefits of technology

It significantly reduces the adsorption of proteins, cells, and microorganisms, decreases M1 macrophage polarization, alleviates inflammatory responses, and provides excellent anti-foreign body reaction effects.

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Abstract

The present application relates to the use of polysialic acid or its derivatives in anti-foreign body reaction, in particular, to a polysialic acid anti-foreign body reaction material for resisting biological contamination, for regulating macrophage phenotype to reduce inflammatory response, and for resisting foreign body reaction. The polysialic acid material includes a bulk material prepared from polysialic acid and its derivatives, or a coating material for surface modification of the material, which can resist protein adsorption, cell adhesion and adhesion of various microorganisms, can act on immune cells, such as regulating the phenotype of macrophages, thereby reducing acute and chronic inflammatory response, and has excellent anti-foreign body reaction effect as an implant material.
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