Nicotine-containing microcapsule and preparation method thereof

Abstract

The invention discloses a nicotine-containing microcapsule and a preparation method thereof, and relates to the technical field of nicotine oral products. The nicotine microcapsule comprises 5-20 parts of gelatin, 20-40 parts of fish gelatin, 20-40 parts of sodium alginate, 1-10 parts of nicotine salt, 1-5 parts of calcium lactate, 1-5 parts of xanthan gum, 1-20 parts of chitosan, 0.1-2 parts of a sweetening agent, 1-10 parts of edible essence, 1-10 parts of an essence solvent and the balance of distilled water. According to the preparation, a certain amount of nicotine salt is added on the basis of an existing microcapsule, part of gelatin is replaced with fish gelatin, on the basis that nicotine intake is met, irritation caused by smoking of a nicotine oral product is improved, the elasticity of an outer film shell of the microcapsule is increased, the texture is soft and smooth, and the preparation is convenient to carry and smoke.

Description

Technical Field

[0001] This invention belongs to the field of nicotine oral products technology, specifically relating to a nicotine-containing microcapsule and its preparation method. Background Technology

[0002] As the international tobacco control movement continues to advance, countries are imposing stricter restrictions on smoking in public places. Smokeless tobacco products, with their unique method of consumption, have been developing and have attracted widespread attention from tobacco companies. Compared to the harmfulness of traditional cigarettes and cigars, smokeless tobacco products are considered less harmful to the human body. Smokeless tobacco products are inhaled through the mouth or nose, requiring no heating or combustion, producing no smoke, eliminating secondhand smoke, and reducing the harm of smoking to public health.

[0003] Currently, smokeless tobacco products mainly exist in the form of pouch cigarettes, nicotine gum, and nicotine sprays. Although these products do not produce smoke during use and satisfy the user's nicotine cravings, they can irritate the oral cavity and cause stomatitis. Nicotine microcapsules, while satisfying the user's nicotine cravings, increase the elasticity and smoothness of the microcapsule outer membrane by adding fish glue, while simultaneously allowing for slow nicotine release, effectively reducing oral irritation and increasing the enjoyment of the microcapsule. Summary of the Invention

[0004] The purpose of this invention is to provide a nicotine-containing microcapsule and its preparation method, which improves the smoking comfort of smokeless tobacco products, reduces problems such as oral inflammation, poor taste, and strong irritation, and is easy to carry and smoke.

[0005] To achieve the above objectives, the technical solution of the present invention is as follows:

[0006] A nicotine-containing microcapsule comprises the following components: a gel layer having a cavity inside; the gel layer is prepared by a cross-linking reaction of water, fish glue, gelatin, sodium alginate, and nicotine salt; and a core layer being a calcium-containing solution including calcium lactate, xanthan gum, chitosan, sweetener, food flavoring, and flavoring solvent.

[0007] The nicotine salt is one or more of tartrate nicotine salt, lactate nicotine salt, and malate nicotine salt.

[0008] The edible flavorings include one or more of the following: peppermint flavoring, blueberry flavoring, watermelon flavoring, and strawberry flavoring.

[0009] The fragrance solvents include one or more of linseed oil, peony seed oil, triacetyl glycerol, and triacetic acid glycerol.

[0010] The sweetener includes one or more of xylitol, erythritol, mannitol, sorbitol, and maltitol.

[0011] The ratio of the fish glue, the gelatin, and the sodium alginate is 1:1:2-3:1:1.

[0012] The concentration of the nicotine salt in the glue layer is 1-3 mg / mL.

[0013] The nicotine microcapsule prepared by the cross-linking reaction of the fish glue and the sodium alginate is characterized by comprising the following steps: preparing an external solution for the cross-linking reaction, preparing a core solution for the microcapsule, and forming the microcapsule.

[0014] A nicotine-containing microcapsule, comprising the following components in 100 parts by weight: 10-20 parts of fish glue, 10-20 parts of gelatin, 20-40 parts of sodium alginate, 1-10 parts of nicotine salt, 1-5 parts of calcium lactate, 1-5 parts of xanthan gum, 1-20 parts of chitosan, 1-10 parts of flavoring essence, 0.1-2 parts of sweetener, 1-10 parts of flavoring solvent, and the balance being distilled water.

[0015] Preferably, the amount of the fish glue is 10 parts.

[0016] Preferably, the amount of the gelatin is 10 parts.

[0017] Preferably, the amount of the sodium alginate is 40 parts.

[0018] Preferably, the nicotine salt is nicotine tartrate, and the amount is 2 parts.

[0019] Preferably, the amount of the calcium lactate is 3 parts.

[0020] Preferably, the amount of the xanthan gum is 2 parts.

[0021] Preferably, the amount of the chitosan is 13 parts.

[0022] Preferably, the flavoring essence is peppermint essence, and the amount is 10 parts.

[0023] Preferably, the sweetener is xylitol, and the amount is 1 part.

[0024] Preferably, the flavoring solvent is flaxseed oil, and the amount is 10 parts.

[0025] The nicotine-containing microcapsule and the preparation method thereof can satisfy the user's demand for smoking nicotine while providing the consumer with a nicotine oral product with soft taste and small stimulation. BRIEF DESCRIPTION OF DRAWINGS

[0026] In order to more clearly illustrate the embodiments of the present application, the following will briefly introduce the drawings required to be used in the embodiments. Obviously, the drawings in the following description are only some embodiments of the present application, and other drawings can be obtained according to the structures shown in the drawings without creative labor for those skilled in the art.

[0027] Figure 1 The figure for comparing the texture characteristics of the examples and the comparative examples of the present application. DETAILED DESCRIPTION

[0028] In order to make the purpose, technical scheme and advantages of the embodiments of the present application more clear, the technical scheme in the embodiments of the present application will be clearly and completely described below. If the specific conditions are not mentioned in the embodiments, the conventional conditions or the conditions suggested by the manufacturer are adopted. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor belong to the protection scope of the present application. [Embodiment 1] The preparation method of the nicotine microcapsule in the embodiment includes the following steps: (1) Preparation of cross-linking reaction external solution: prepare a fish glue and sodium alginate compound solution with a certain concentration by using pure water respectively, and heat and dissolve at 85-100℃. Mix the prepared fish glue and gelatin compound solution with the sodium alginate solution uniformly by stirring, and add a certain amount of nicotine salt, heat in a 40℃ water bath and mix uniformly by stirring, to obtain an external solution containing nicotine. (2) Preparation of microcapsule core solution: add a certain amount of calcium lactate and xanthan gum into an appropriate amount of essence solvent and edible essence, and mix uniformly by stirring, and then obtain the microcapsule core solution after standing and removing bubbles. (3) Microcapsule forming: introduce the external solution into the gelatin pot of the gelatin pill machine, heat the gelatin pot of the gelatin pill machine and set the temperature of the gelatin pot of the gelatin pill machine to maintain at 85-120℃; pour the core solution into the core solution pot and the cooling pot of the gelatin pill machine, cool the cooling pot of the gelatin pill machine and set the temperature of the cooling pot of the gelatin pill machine to maintain at 5-15℃; use the gelatin pill machine to drop and form, take out the small balls after a certain time, rinse with distilled water, place in a certain concentration of chitosan solution for 10min, and then rinse with distilled water again to obtain the microcapsule. The nicotine-containing microcapsule includes fish glue, gelatin, sodium alginate, nicotine tartrate, calcium lactate, xanthan gum, chitosan, peppermint essence, linseed oil and the balance of water. According to the weight, the weight parts of each component are as follows: fish glue 10 parts, gelatin 10 parts, sodium alginate 40 parts, nicotine tartrate 2 parts, calcium lactate 3 parts, xanthan gum 2 parts, chitosan 12 parts, xylitol 1 part, edible essence 10 parts, essence solvent 10 parts, and the balance of distilled water. Mix uniformly to prepare. [Example 2] The nicotine-containing microcapsule comprises fish glue, gelatin, sodium alginate, nicotine tartrate, calcium lactate, xanthan gum, chitosan, peppermint essence, linseed oil, and the balance is water. The weight fractions of the components are as follows: fish glue 10 parts, gelatin 10 parts, sodium alginate 40 parts, nicotine tartrate 5 parts, calcium lactate 3 parts, xanthan gum 2 parts, chitosan 9 parts, xylitol 1 part, edible essence 10 parts, essence solvent 10 parts, and the balance is distilled water. The preparation method of Example 2 is the same as that of Example 1, except that the weight fractions of the components are different. The nicotine microcapsule of Example 2 is prepared according to the preparation method of Example 1. [Comparative Example 1] The nicotine-containing microcapsule does not contain nicotine tartrate. The components are as follows: fish glue 10 parts, gelatin 10 parts, sodium alginate 40 parts, calcium lactate 3 parts, xanthan gum 2 parts, chitosan 14 parts, xylitol 1 part, edible essence 10 parts, essence solvent 10 parts, and the balance is distilled water. The preparation method of Comparative Example 1 is the same as that of Example 1, except that no nicotine tartrate is added. The nicotine microcapsule of Comparative Example 1 is prepared according to the preparation method of Example 1. [Comparative Example 2] The nicotine-containing microcapsule comprises gelatin, sodium alginate, nicotine tartrate, calcium lactate, xanthan gum, chitosan, peppermint essence, linseed oil, and the balance is water. The weight fractions of the components are as follows: gelatin 20 parts, sodium alginate 40 parts, calcium lactate 3 parts, xanthan gum 2 parts, chitosan 14 parts, xylitol 1 part, edible essence 10 parts, essence solvent 10 parts, and the balance is distilled water. The preparation method of Comparative Example 2 is the same as that of Example 2, except that fish glue is replaced by gelatin. The nicotine microcapsule of Comparative Example 2 is prepared according to the preparation method of Example 1.

[0029] Sensory flavor evaluation:

[0030] To prove the technical effect of the present application, sensory evaluation of the nicotine microcapsules of Examples 1-2 and Comparative Examples 1-2 is compared. The sensory quality evaluation is conducted by a snus evaluation team consisting of 20 snus evaluation personnel trained in snus evaluation, Table 1 Sensory flavor evaluation table of microcapsules Table 2. Evaluation of Nicotine Microcapsule Absorption in Different Implementations and Control Cases

[0031] The results in Table 2 show that, preferably, Example 1 is the best embodiment of the present invention. The components consist of 20 parts fish glue, 40 parts sodium alginate, 3 parts calcium lactate, 2 parts xanthan gum, 15 parts chitosan, 10 parts edible flavoring, 10 parts flavoring solvent, and the remainder is distilled water. These are mixed evenly to form nicotine-containing microcapsules. The capsules have a moderate sweetness, a refreshing taste, a fresh and rich aroma, a smooth and resilient outer shell, minimal irritation, a fast and long-lasting release rate, and a good user experience.

[0032] Texture properties:

[0033] Ten microcapsules were prepared for each group. The hardness, adhesiveness, and chewiness of the microcapsules were measured using a TMS-Pilot texture analyzer. The measurement parameters were set as follows: cylindrical probe, pressure test type, deformation target mode, deformation amount of 50%, time 2 s, detection speed 60 mm / min, trigger force 0.75 N, and force sensor range 500 N. Three trials were conducted for each group, and the average value was taken.

[0034] The results are as follows Figure 1 As shown, sodium alginate molecules can bind with calcium ions to form a cross-linked structure. The addition of fish glue makes this structure more compact, resulting in microcapsules with a smoother, fuller appearance, higher hardness, and improved mechanical properties of the gel membrane, including increased elongation at break and water content. Microcapsules cured with chitosan solution exhibit reduced surface porosity and a more tightly bound gel layer, thus increasing chewability with increasing chitosan solution concentration. Sodium alginate on the microcapsule surface can form polyelectrolyte complexes with chitosan through electrostatic interactions, and the microcapsules are covered by a chitosan layer. However, the outer membrane of the microcapsule and calcium... 2+After the reaction to form the microcapsules, a gel layer has been formed on the surface. A certain concentration of chitosan can make the positively charged amino groups enter the gel layer and combine with the negatively charged carboxyl groups in alginate, making the gel layer more tightly combined, which can help to improve the mechanical stability and permeability of the microcapsules, and the hardness of the microcapsules also increases. However, as the concentration of chitosan increases, the gel layer cannot combine the corresponding amino groups, and the swelling rate of the prepared microcapsules increases, resulting in a decrease in the hardness of the microcapsules. The addition amount of xanthan gum affects the amount of calcium ions in the core liquid of the burst bead, causing the ratio of calcium ions to sodium alginate to change during the cross-linking reaction. When the addition amount of xanthan gum is too high, the concentration of calcium ions decreases, thereby affecting the mechanical strength of the formed gel, resulting in a decrease in the hardness and chewiness of the burst bead, and the shape becomes flat and the taste is poor. Therefore, the preparation method of Example 1 and the amounts of the components are selected to prepare the nicotine-containing microcapsules, which have a smooth and full appearance, high hardness, good chewiness, and provide a better taste for consumers.

[0035] The above merely describes the preferred embodiments of the present application, and does not limit the patent scope of the present application. For those skilled in the art, the present application can have various modifications and changes. Any modification, equivalent replacement, improvement, etc. made within the spirit and principles of the present application shall be included in the patent protection scope of the present application.

Claims

1. A nicotine-containing microcapsule and a method for preparing the same, characterized by, The application relates to a nicotine microcapsule, which comprises the following steps: The application relates to a nicotine microcapsule, which comprises the following steps:

2. The nicotine-containing microcapsule according to claim 1, wherein, The nicotine salt is one or more of tartaric acid nicotine salt, lactic acid nicotine salt and malic acid nicotine salt.

3. The nicotine-containing microcapsule and the preparation method thereof according to claim 1, characterized in that, The edible essence comprises one or more of mint essence, blueberry essence, watermelon essence and strawberry essence.

4. The nicotine-containing microcapsule and its preparation method according to claim 1, characterized in that, The essence solvent comprises one or more of linseed oil, peony seed oil, glycerol triacetate and glycerol triacetate.

5. The nicotine-containing microcapsule according to claim 1, wherein The ratio of fish glue to sodium alginate is 1:2-3:

1.

6. The nicotine-containing microcapsule according to claim 1, wherein The concentration of the nicotine salt in the glue layer is 1-3 mg / mL.

7. The nicotine-containing microcapsule according to claim 1, wherein The sweetener is one or more of xylitol, erythritol, mannitol, sorbitol and maltitol.

8. A nicotine-containing microcapsule and a method for preparing the same, for a nicotine microcapsule prepared by cross-linking reaction of a sodium alginate compounded with a mixed solution of fish glue and gelatin according to any one of claims 1 to 7, characterized in that, The application relates to a nicotine microcapsule, which comprises the following steps: (1) preparing a cross-linking reaction external solution: preparing a compound solution of fish glue and gelatin with a certain concentration by using purified water respectively, and heating and dissolving the compound solution at 85-100 DEG C; mixing the prepared fish glue and gelatin mixed solution with a certain amount of sodium alginate solution, adding a certain amount of nicotine salt, heating in a 40 DEG C water bath and fully stirring and mixing, so as to obtain an external solution containing nicotine. (2) preparing a microcapsule core solution: adding a certain amount of calcium lactate and xanthan gum into edible essence, essence solvent and sweetener, stirring uniformly, and obtaining a microcapsule core solution after standing and removing bubbles. (3) forming the microcapsule: introducing the external solution into a glue pill machine glue solution tank, heating the glue pill machine glue solution tank and setting the glue pill machine glue solution tank temperature to be maintained at 85-120 DEG C; pouring the core solution into a glue pill machine core solution tank and a glue pill machine cooling tank, cooling the glue pill machine cooling tank and setting the glue pill machine cooling tank temperature to be maintained at 5-15 DEG C; using the glue pill machine to drop and form, taking out the small balls after a certain time, rinsing the small balls with distilled water, placing the small balls in a certain concentration of chitosan solution for solidification for 10 min, and finally rinsing the small balls with distilled water, so as to obtain the microcapsule.

9. The nicotine-containing microcapsule according to claim 1, wherein The addition amount of the xanthan gum is 0.5-1%.

10. The nicotine-containing microcapsule and its preparation method according to claim 1, characterized in that, The concentration of the chitosan solidification solution is 0.1-1%.

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