Skin care moisturizing and detumescence reagent and preparation method thereof

Abstract

The invention belongs to the technical field of medical skin care, and particularly relates to a skin care moisturizing and detumescence reagent and a preparation method thereof. The skin care moisturizing and detumescence reagent is prepared from the following raw materials in parts by weight: 5 to 15 parts of eutectic solvent, 1 to 5 parts of moisturizing and detumescence microspheres, 2 to 4 parts of panthenol and 0.1 to 0.4 part of carbomer. A deep eutectic solvent prepared from L-menthol and decanoic acid is adopted, favorable conditions are created for attachment and permeation of the moisturizing and detumescence microspheres on the skin surface, the subsequent continuous permeation promotion effect and the sustained release process of the microsphere cores are synchronously carried out, and seamless connection of release and permeation of active ingredients is achieved. The moisturizing and detumescence microsphere shell layer is quickly dissolved after being in contact with the postoperative skin, and the released moisturizing component can instantly moisten and repair the skin barrier; and then, the detumescence component of the inner core begins to be slowly released and deeply acts under the boosting of the eutectic solvent, so that the maximization and persistence of the efficacy are realized.

Description

Technical Field

[0001] This invention belongs to the field of medical skin care technology, specifically relating to a skin care moisturizing and swelling-reducing reagent and its preparation method. Background Technology

[0002] Dryness, dehydration, and inflammatory redness and swelling caused by a damaged skin barrier are core medical care challenges in the repair of allergic dermatitis and sensitive skin, as well as post-operative care. In such cases, care products not only need to meet basic moisturizing and barrier repair needs, but also need to meet medical-grade requirements such as precise anti-inflammatory and swelling-reducing effects, gentleness and non-irritation, and long-lasting efficacy. They must quickly relieve post-operative redness, swelling, and burning sensations, regulate the root cause of inflammation through deep penetration, and be compatible with the physiological tolerance of damaged skin.

[0003] However, existing similar products are mostly limited to general skincare and cannot meet the stringent requirements of medical settings. On the one hand, anti-inflammatory and swelling-reducing active ingredients (such as dipotassium glycyrrhizate) often act superficially with low transdermal efficiency, failing to effectively penetrate the dermis to regulate the release of inflammatory factors, resulting in slow postoperative redness and swelling reduction. On the other hand, moisturizing ingredients and active ingredients have poor synergy and lack dedicated pharmaceutical carriers, leading to either easy inactivation of active ingredients or increased skin irritation due to the addition of chemical solubilizers. Furthermore, ordinary formulations struggle to balance rapid onset and long-lasting effects, failing to meet the dual needs of immediate soothing and continuous repair in medical settings. Therefore, developing a medical moisturizing and swelling-reducing formulation with strong ingredient synergy, high transdermal efficiency, and rapid swelling reduction has become a pressing technical problem to be solved in this field. Summary of the Invention

[0004] To address the shortcomings of existing technologies, this invention proposes a skin care moisturizing and anti-swelling reagent and its preparation method. This invention uses a eutectic solvent and core-shell structured moisturizing and anti-swelling microspheres as the core composite system. The eutectic solvent is prepared from L-menthol and decanoic acid. The moisturizing and anti-swelling microspheres have an oil core of caprylic / capric triglyceride encapsulating anti-inflammatory and anti-swelling active pharmaceutical ingredients, and sodium alginate and sodium hyaluronate forming a water shell to create a moisturizing layer. These two components are then fused with a medical aqueous matrix through a scientific process to form a transparent gel. Through the synergistic effect of the eutectic solvent's penetration-enhancing properties and the sustained-release characteristics of the moisturizing and anti-swelling microspheres, efficient penetration and long-lasting effects of the active ingredients are achieved. Simultaneously, a multi-layered moisturizing network is constructed to repair the skin barrier, achieving a deep synergistic effect of moisturizing and anti-swelling. This solves the technical problems of existing similar reagents, such as poor synergistic efficacy, low transdermal efficiency of active ingredients, short duration of efficacy, low adaptability to medical scenarios, and high risk of irritation.

[0005] This invention provides a skin care moisturizing and anti-swelling agent, which comprises the following raw materials in parts by weight: 5-15 parts of eutectic solvent, 1-5 parts of moisturizing and anti-swelling microspheres, 2-4 parts of panthenol, 0.1-0.4 parts of carbomer, 4-8 parts of glycerin, and 0.5-1 part of phenoxyethanol. The eutectic solvent comprises the following raw materials in the following mass ratio: L-menthol:decanoic acid = 1:1-1.5; The method for preparing the eutectic solvent includes the following steps: Weigh L-menthol and decanoic acid, place them in a dry container, and put them in a constant temperature water bath at 60-70 ℃. Stir for 45 min until the mixture changes from an opaque turbid liquid to a completely clear, transparent, homogeneous liquid. Remove it from the water bath and let it stand and cool at room temperature to obtain a eutectic solvent.

[0006] The moisturizing and anti-swelling microspheres comprise the following raw materials in the following mass ratio: hydrogenated lecithin: caffeine: aescin: sodium alginate: sodium hyaluronate: glycerin = 2-3:4:1:10:2:30-50; The preparation method of the moisturizing and anti-swelling microspheres includes the following steps: (a) Weigh out hydrogenated lecithin, caffeine and aescin, add caprylic acid triglyceride as an oil phase carrier, the mass ratio of caprylic acid triglyceride to hydrogenated lecithin is 10-20:1, place in a 60℃ constant temperature water bath, stir, and obtain a clear oil phase solution. (b) Weigh sodium alginate, sodium hyaluronate and glycerin, add deionized water, the ratio of deionized water to sodium alginate is 100-200 mL: 1 g, and then stir magnetically at 500 rpm for 3 h at room temperature to form a shell aqueous phase solution. (c) The oil phase solution prepared in step (a) is slowly added dropwise to the shell aqueous phase solution prepared in step (c) under shear, wherein the volume ratio of the oil phase solution to the shell aqueous phase solution is 1:4-6. After the addition is completed, the same shear rate is maintained for shearing for 4 min to form a stable primary emulsion. (d) Weigh calcium chloride and prepare a 2% (w / v) calcium chloride aqueous solution as a crosslinking agent. Use a syringe to add the pre-emulsion obtained in step (c) dropwise to the calcium chloride solution. The volume ratio of calcium chloride solution to pre-emulsion is 3-5:1. Stir gently at room temperature for 30 min to form solidified core-shell microspheres. (e) Allow the core-shell microspheres to settle naturally, discard the supernatant, collect the settled core-shell microspheres, resuspend the core-shell microspheres in deionized water, allow them to settle again, discard the supernatant again, wash repeatedly to obtain a wet product of the core-shell structured microsphere complex, freeze-dry to obtain a dry powdery moisturizing and anti-swelling microsphere.

[0007] This invention also provides a method for preparing a skin care moisturizing and anti-swelling agent, specifically including the following steps: S1, take a eutectic solvent, add panthenol to it, stir until completely dissolved, and obtain an active concentrate; S2, Carbomer is dispersed in deionized water at a ratio of 50 mL: 1 g. The mixture is stirred at high speed until it swells. Then, glycerol is added and stirred at low speed until homogeneous. Under low speed stirring, the active concentrate is slowly added to the aqueous matrix. Then, moisturizing and anti-swelling microspheres are added and homogenized for 5 minutes to form a composite system. S3. Triethanolamine is slowly added dropwise to the composite system to adjust the pH value to 5-6. Then phenoxyethanol is added, and the total mass is made up to 100 parts by weight with deionized water. The mixture is stirred at low speed until homogeneous, and after standing to defoam, it is discharged to obtain a skin care moisturizing and anti-swelling reagent.

[0008] Compared with the prior art, the beneficial effects achieved by the present invention are as follows: This invention utilizes a eutectic solvent prepared from L-menthol and decanoic acid. This solvent not only possesses a soothing feel and basic moisturizing capabilities, instantly relieving postoperative dryness, itching, stinging, and burning sensations, but also opens highly efficient penetration channels for active ingredients by disrupting the lipid structure of the stratum corneum. The moisturizing and anti-swelling microspheres, acting as physical carriers, achieve dual empowerment through their specific structure. Their oil core can encapsulate anti-inflammatory and anti-swelling ingredients such as caffeine and aescin, enabling controlled release and enhancing the longevity of the effect. The sodium alginate and sodium hyaluronate in the water shell can form a complementary moisturizing network with decanoic acid and panthenol in the eutectic solvent, achieving multiple functions including surface hydration, moisture retention, and skin barrier repair. The eutectic solvent first creates favorable conditions for the adhesion and penetration of the moisturizing and anti-swelling microspheres on the skin surface. Subsequently, its continuous penetration-enhancing effect and the slow-release process of the microsphere core proceed simultaneously, achieving a seamless connection between the release and penetration of active ingredients. The shell of the moisturizing and anti-swelling microspheres dissolves rapidly upon contact with postoperative skin, releasing moisturizing ingredients that instantly hydrate and repair the skin barrier. This provides immediate comfort and creates a favorable skin environment for the penetration of subsequent anti-swelling ingredients, reducing transepidermal water loss and preventing dryness from hindering the healing process. Subsequently, the anti-swelling ingredients in the core begin to be slowly released and, aided by the eutectic solvent, penetrate deeply to achieve anti-inflammatory and anti-swelling effects. During use, the eutectic solvent ensures rapid initial penetration, while the moisturizing and anti-swelling microspheres provide sustained blood drug concentrations through slow release, together extending the effective duration of action. The formation of the eutectic solvent itself neutralizes some of the properties of decanoic acid, and its combination with the moisturizing and anti-swelling microspheres further controls the release rate, avoiding the instantaneous impact of high-concentration active ingredients on the skin, thus achieving efficient penetration while significantly reducing potential irritation. Attached Figure Description

[0009] Figure 1 This is a schematic diagram of the structure of the moisturizing and anti-swelling microspheres prepared in this invention; Figure 2 Transdermal absorption performance diagram of the skin care moisturizing and anti-swelling reagent prepared in this invention. Detailed Implementation

[0010] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative effort are within the scope of protection of the present invention.

[0011] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those familiar to those skilled in the art. Furthermore, any methods and materials similar to or equivalent to those described herein may be applied to this invention. The preferred embodiments and materials described herein are for illustrative purposes only and do not limit the scope of this application.

[0012] Example 1: This example provides a skin care moisturizing and anti-swelling agent, which includes the following raw materials in parts by weight: 5 parts eutectic solvent, 1 part moisturizing and anti-swelling microspheres, 2 parts panthenol, 0.1 part carbomer, 4 parts glycerin, and 0.5 parts phenoxyethanol. The eutectic solvent comprises the following raw materials in the following mass ratio: L-menthol:decanoic acid = 1:1; The method for preparing the eutectic solvent includes the following steps: Weigh L-menthol and decanoic acid, place them in a dry container, and put them in a constant temperature water bath at 60 ℃. Stir at 200 rpm for 45 min using a magnetic stirrer or mechanical stirrer until the mixture changes from an opaque turbid liquid to a completely clear, transparent, homogeneous liquid. Remove it from the water bath and let it stand and cool at room temperature to obtain a eutectic solvent.

[0013] The moisturizing and anti-swelling microspheres comprise the following raw materials in the following mass ratio: hydrogenated lecithin: caffeine: aescin: sodium alginate: sodium hyaluronate: glycerin = 2:4:1:10:2:30; The preparation method of the moisturizing and anti-swelling microspheres includes the following steps: (a) Weigh out hydrogenated lecithin, caffeine and aescin, add caprylic acid triglyceride as an oil phase carrier, the mass ratio of caprylic acid triglyceride to hydrogenated lecithin is 10:1, place in a 60 ℃ constant temperature water bath, stir at 300 rpm until all solid substances are completely dissolved, and obtain a clear oil phase solution. (b) Weigh sodium alginate, sodium hyaluronate and glycerin, add deionized water, the ratio of deionized water to sodium alginate is 100 mL: 1 g, and then stir magnetically at 500 rpm for 3 h at room temperature until sodium alginate and sodium hyaluronate are completely dissolved to form a homogeneous, transparent viscous aqueous shell solution. (c) The oil phase solution prepared in step (a) is slowly added dropwise to the shell aqueous phase solution prepared in step (c) at a shear rate of 10,000 rpm, wherein the volume ratio of the oil phase solution to the shell aqueous phase solution is 1:4. After the addition is completed, the shear rate is maintained at 10,000 rpm for 4 min to form a stable milky white promulgation. (d) Weigh calcium chloride and prepare a 2% (w / v) calcium chloride aqueous solution as a crosslinking agent. Use a syringe to add the pre-emulsion obtained in step (c) dropwise to the calcium chloride solution. The volume ratio of calcium chloride solution to pre-emulsion is 3:1. At room temperature, gently stir at 350 rpm for 30 min to form solidified core-shell microspheres. (e) Allow the core-shell microspheres to settle naturally, discard the supernatant, collect the settled core-shell microspheres, resuspend the core-shell microspheres in deionized water, allow them to settle again, discard the supernatant again, repeat this washing process twice to remove unencapsulated active ingredients and residual cross-linking agents, and obtain a wet product of the core-shell structured microsphere complex. Freeze-dry to obtain dry powdered moisturizing and anti-swelling microspheres.

[0014] This embodiment also provides a method for preparing a skin care moisturizing and anti-swelling agent, specifically including the following steps: S1, take a eutectic solvent, add panthenol to it, stir until completely dissolved, and obtain an active concentrate; S2, carbomer was dispersed in deionized water at a ratio of 50 mL: 1 g. The mixture was stirred at high speed until it swelled. Then glycerin was added and stirred at low speed until homogeneous. The active concentrate was slowly added to the aqueous matrix under low speed stirring. Then moisturizing and anti-swelling microspheres were added. The mixture was homogenized at 3000 rpm for 5 minutes to form a composite system. S3. Triethanolamine is slowly added dropwise to the composite system to adjust the pH value to 5, and the composite system turns into a transparent gel. Then, phenoxyethanol is added, and the total mass is made up to 100 parts by weight with deionized water. The mixture is stirred at low speed until homogeneous, and after standing to defoam, it is discharged to obtain a skin care moisturizing and anti-swelling reagent.

[0015] Example 2: This example provides a skin care moisturizing and anti-swelling agent, which includes the following raw materials in parts by weight: 10 parts eutectic solvent, 3 parts moisturizing and anti-swelling microspheres, 3 parts panthenol, 0.2 parts carbomer, 5 parts glycerin, and 0.8 parts phenoxyethanol. The eutectic solvent comprises the following raw materials in the following mass ratio: L-menthol:decanoic acid = 1:1.25; The method for preparing the eutectic solvent includes the following steps: Weigh L-menthol and decanoic acid, place them in a dry container, and put them in a constant temperature water bath at 70 ℃. Stir at 300 rpm for 45 min using a magnetic stirrer or mechanical stirrer until the mixture changes from an opaque turbid liquid to a completely clear, transparent, homogeneous liquid. Remove it from the water bath and let it stand and cool at room temperature to obtain a eutectic solvent.

[0016] The moisturizing and anti-swelling microspheres comprise the following raw materials in the following mass ratio: hydrogenated lecithin: caffeine: aescin: sodium alginate: sodium hyaluronate: glycerin = 2.5:4:1:10:2:40; The preparation method of the moisturizing and anti-swelling microspheres includes the following steps: (a) Weigh out hydrogenated lecithin, caffeine and aescin, add caprylic acid triglyceride as an oil phase carrier, the mass ratio of caprylic acid triglyceride to hydrogenated lecithin is 15:1, place in a 60 ℃ constant temperature water bath, stir at 300 rpm until all solid substances are completely dissolved, and obtain a clear oil phase solution. (b) Weigh sodium alginate, sodium hyaluronate and glycerin, add deionized water, the ratio of deionized water to sodium alginate is 150mL:1g, and then stir magnetically at 500 rpm for 3 h at room temperature until sodium alginate and sodium hyaluronate are completely dissolved to form a homogeneous, transparent viscous aqueous shell solution. (c) The oil phase solution prepared in step (a) is slowly added dropwise to the shell aqueous phase solution prepared in step (c) at a shear rate of 10,000 rpm, wherein the volume ratio of the oil phase solution to the shell aqueous phase solution is 1:5. After the addition is completed, the shear rate is maintained at 10,000 rpm for 4 min to form a stable milky white promulgation. (d) Weigh calcium chloride and prepare a 2% (w / v) calcium chloride aqueous solution as a crosslinking agent. Use a syringe to add the pre-emulsion obtained in step (c) dropwise to the calcium chloride solution. The volume ratio of calcium chloride solution to pre-emulsion is 4:1. At room temperature, gently stir at 350 rpm for 30 min to form solidified core-shell microspheres. (e) Allow the core-shell microspheres to settle naturally, discard the supernatant, collect the settled core-shell microspheres, resuspend the core-shell microspheres in deionized water, allow them to settle again, discard the supernatant again, repeat this washing process 3 times to remove unencapsulated active ingredients and residual cross-linking agents, and obtain a wet product of the core-shell structured microsphere complex. Freeze-dry to obtain dry powdered moisturizing and anti-swelling microspheres.

[0017] This embodiment also provides a method for preparing a skin care moisturizing and anti-swelling agent, specifically including the following steps: S1, take a eutectic solvent, add panthenol to it, stir until completely dissolved, and obtain an active concentrate; S2, carbomer was dispersed in deionized water at a ratio of 50 mL: 1 g. The mixture was stirred at high speed until it swelled. Then glycerin was added and stirred at low speed until homogeneous. The active concentrate was slowly added to the aqueous matrix under low speed stirring. Then moisturizing and anti-swelling microspheres were added. The mixture was homogenized at 3000 rpm for 5 minutes to form a composite system. S3. Triethanolamine is slowly added dropwise to the composite system to adjust the pH value to 5.3. As the composite system turns into a transparent gel, phenoxyethanol is added, and the total mass is made up to 100 parts by weight with deionized water. The mixture is stirred at low speed until homogeneous, and after standing to defoam, it is discharged to obtain a skin care moisturizing and anti-swelling reagent.

[0018] Example 3: This example provides a skin care moisturizing and anti-swelling agent, which includes the following raw materials in parts by weight: 15 parts eutectic solvent, 5 parts moisturizing and anti-swelling microspheres, 4 parts panthenol, 0.4 parts carbomer, 8 parts glycerin, and 1 part phenoxyethanol. The eutectic solvent comprises the following raw materials in the following mass ratio: L-menthol:decanoic acid = 1:1.5; The method for preparing the eutectic solvent includes the following steps: Weigh L-menthol and decanoic acid, place them in a dry container, and put them in a constant temperature water bath at 70 °C. Stir at 400 rpm for 45 min using a magnetic stirrer or mechanical stirrer until the mixture changes from an opaque turbid liquid to a completely clear, transparent, homogeneous liquid. Remove the mixture from the water bath and allow it to cool at room temperature to obtain a eutectic solvent.

[0019] The moisturizing and anti-swelling microspheres comprise the following raw materials in the following mass ratio: hydrogenated lecithin: caffeine: aescin: sodium alginate: sodium hyaluronate: glycerin = 3:4:1:10:2:50; The preparation method of the moisturizing and anti-swelling microspheres includes the following steps: (a) Weigh out hydrogenated lecithin, caffeine and aescin, add caprylic acid triglyceride as an oil phase carrier, the mass ratio of caprylic acid triglyceride to hydrogenated lecithin is 20:1, place in a 60°C constant temperature water bath, stir at 300 rpm until all solid substances are completely dissolved, and obtain a clear oil phase solution. (b) Weigh sodium alginate, sodium hyaluronate and glycerin, add deionized water, the ratio of deionized water to sodium alginate is 200mL:1g, and then stir magnetically at 500 rpm for 3 h at room temperature until sodium alginate and sodium hyaluronate are completely dissolved to form a homogeneous, transparent viscous shell aqueous solution. (c) The oil phase solution prepared in step (a) is slowly added dropwise to the shell aqueous phase solution prepared in step (c) at a shear rate of 10,000 rpm, wherein the volume ratio of the oil phase solution to the shell aqueous phase solution is 1:6. After the addition is completed, the shear rate is maintained at 10,000 rpm for 4 min to form a stable milky white promulgation. (d) Weigh calcium chloride and prepare a calcium chloride aqueous solution with a mass-volume concentration of 2% as a crosslinking agent. Use a syringe to add the pre-emulsion obtained in step (c) dropwise to the calcium chloride solution. The volume ratio of calcium chloride solution to pre-emulsion is 5:1. At room temperature, gently stir at a speed of 350 rpm for 30 min to form solidified core-shell microspheres. (e) Allow the core-shell microspheres to settle naturally, discard the supernatant, collect the settled core-shell microspheres, resuspend the core-shell microspheres in deionized water, allow them to settle again, discard the supernatant again, repeat this washing process 4 times to remove unencapsulated active ingredients and residual cross-linking agents, and obtain a wet product of the core-shell structured microsphere complex. Freeze-dry to obtain dry powdered moisturizing and anti-swelling microspheres.

[0020] This embodiment also provides a method for preparing a skin care moisturizing and anti-swelling agent, specifically including the following steps: S1, take a eutectic solvent, add panthenol to it, stir until completely dissolved, and obtain an active concentrate; S2, carbomer was dispersed in deionized water at a ratio of 50 mL: 1 g. The mixture was stirred at high speed until it swelled. Then glycerol was added and stirred at low speed until homogeneous. Under low speed stirring, the active concentrate was slowly added to the aqueous matrix. Then, moisturizing and anti-swelling microspheres were added and homogenized at 3000 rpm for 5 min to form a composite system. S3. Triethanolamine is slowly added dropwise to the composite system to adjust the pH value to 6. As the composite system turns into a transparent gel, phenoxyethanol is added, and the total mass is made up to 100 parts by weight with deionized water. The mixture is stirred at low speed until homogeneous, and after standing to defoam, it is discharged to obtain a skin care moisturizing and anti-swelling reagent.

[0021] The difference between Comparative Example 1 and Example 2 is that no eutectic solvent was added; the rest is exactly the same as Example 2.

[0022] The difference between Comparative Example 2 and Example 2 is that decanoic acid was not added; the rest of the parts are exactly the same as Example 2.

[0023] The difference between Comparative Example 3 and Example 2 is that moisturizing and anti-swelling microspheres were not added; the rest of the parts are exactly the same as Example 2.

[0024] Experimental example: 1. Moisturizing Performance Test: Sixty healthy female volunteers, aged 25-45, were recruited. Skin moisture content was tested using a skin moisture testing probe in an environment of 20°C and 50% relative humidity. The test site was the inner forearm of the volunteers. Volunteers sat quietly in the test environment for 20 minutes, and the initial skin moisture content of the test site was measured. Then, 50 mg of the skin care moisturizing and anti-swelling reagents prepared in Examples 1-3 and Comparative Examples 1-3 of this invention were evenly applied. Skin moisture content was measured again at the same site at 0.5 hours, 2 hours, 4 hours, and 8 hours after application, and the increase relative to the initial value was calculated. The results are recorded in Table 1.

[0025] Table 1: Results of Moisturizing Performance Test

[0026] Table 1 shows that Examples 1-3 exhibited high skin moisture content at all time points and had a long-lasting moisturizing effect. The moisturizing effects of Comparative Examples 1 and 2 were weaker than those of Examples 1-3, indicating that the eutectic solvent system prepared in this invention played a good role in enhancing and maintaining the moisturizing effect. Comparative Example 3 had a good moisturizing effect within 0.5 J, but its moisturizing ability decreased sharply in the later stage, indicating that without the addition of moisturizing and anti-swelling microspheres, a long-lasting moisturizing effect could not be achieved.

[0027] 2. Anti-swelling efficacy test: The anti-swelling efficacy was tested using a high-frequency skin ultrasound diagnostic system. The skin care moisturizing and anti-swelling reagents prepared in Examples 1-3 and Comparative Examples 1-3 of this invention were used as samples. The test population consisted of 25 healthy female volunteers aged 28-50 years, all of whom experienced morning puffiness around the eyes. The test method was as follows: After the volunteers woke up in the morning, the initial skin thickness at the same marked point on both lower eyelids was measured. 100 mg of the sample of this invention was applied to one eye area, while the other eye area was left untreated as a blank control. Skin thickness changes at the same marked point were measured using skin ultrasound at 30, 60, and 120 minutes after application. The results are recorded in Table 2.

[0028] 3. Skin Mildness Test: Healthy subjects and subjects with sensitive skin were selected for a human repeat patch test to test the mildness of the prepared skin care moisturizing and anti-swelling reagent. 0.02 mL of the reagent prepared in Examples 1-3 and Comparative Examples 1-3 of this invention was injected into a dedicated patch applicator. The applicator was applied to normal skin on the outer side of the volunteer's upper arm. After 24 hours, the applicator was removed. A dermatologist observed and recorded skin reactions such as erythema and edema at the application site at 0.5 hours, 24 hours, and 48 hours, and scored them according to standards. The scoring results are shown in Table 2.

[0029] Table 2: Results of Anti-swelling Efficacy and Skin Mildness Tests

[0030] Table 2 shows that Examples 1-3 exhibited significant anti-swelling effects at all time points. Furthermore, the effect continued to increase over time. Comparative Examples 1 and 2 showed weaker anti-swelling effects compared to Examples 1-3, indicating that the efficient penetration-enhancing effect of the eutectic solvent system ensured a good anti-swelling effect. Comparative Example 3 showed slow improvement in anti-swelling effect in the later stages, indicating that the moisturizing and anti-swelling microspheres could continuously exert their efficacy, achieving a good anti-swelling effect.

[0031] Figure 1 This is a schematic diagram of the structure of the moisturizing and anti-swelling microspheres prepared according to the present invention, showing the complete core-shell structure of the microspheres before use. It consists of two layers from the outside in: an outer shell and an inner core. The outer shell is composed of sodium alginate, sodium hyaluronate, and glycerin; the core is composed of caffeine, aescin, and hydrogenated lecithin. Upon contact with skin moisture, the moisturizing and anti-swelling microspheres enter the shell dissolution and release phase. During this phase, the shell undergoes rapid hydration and dissolution, and the moisturizing ingredients it carries are immediately released to the skin surface through dissolution, achieving rapid moisturizing and barrier repair. Then, the core diffuses and releases. As the shell thins and disappears, the anti-swelling active ingredients in the core are released slowly through diffusion via opened channels, penetrating deep into the skin to provide a long-lasting and gentle anti-swelling effect.

[0032] Figure 2 The graphs show the cumulative transdermal absorption of the skin care moisturizing and anti-swelling agents prepared in Examples 2 and 1-3 of this invention over time. As shown in the figure, the curve of Comparative Example 1 is flat throughout, indicating that the skin care moisturizing and anti-swelling agent prepared in Comparative Example 1 has a slow onset of action and low transdermal efficiency. The slope of Comparative Example 3 gradually flattens, indicating that the skin care moisturizing and anti-swelling agent prepared in Comparative Example 2 cannot maintain its efficacy for a long time. The curve of Example 2 maintains a high slope for a long time, indicating that the initial penetration of the prepared eutectic solvent and the long-term maintenance of the moisturizing and anti-swelling microspheres have achieved good moisturizing and anti-swelling effects.

[0033] In summary, this invention successfully prepared a medical-grade skin care reagent with excellent moisturizing and anti-swelling effects by constructing a composite system of a eutectic solvent and core-shell structured moisturizing and anti-swelling microspheres, combined with scientific formulation design and process optimization. The eutectic solvent not only possesses soothing and basic moisturizing capabilities but also provides a highly efficient transdermal channel for the active ingredients in the core-shell microspheres. The core-shell microspheres, through their unique oil-core-water-shell structure, achieve long-lasting sustained release and stable protection of the active ingredients. The synergistic effect of these two components overcomes the limitations of traditional reagents, such as fragmented efficacy and short duration of action. Simultaneously, the various raw materials work together to enhance moisturizing and anti-swelling effects while optimizing skin feel and stability, reducing the risk of skin irritation, and forming a complete closed-loop care system of immediate soothing, deep action, and long-lasting maintenance. The entire technical solution achieves a comprehensive improvement in efficacy and practicality through the functional complementarity between components and precise process adaptation.

[0034] The present invention and its embodiments have been described above. This description is not restrictive, and the accompanying drawings are only one embodiment of the present invention. The actual application is not limited to this. In conclusion, if those skilled in the art are inspired by this description and design similar methods and embodiments without departing from the spirit of the present invention, they should all fall within the protection scope of the present invention.

Claims

1. A skin care moisturizing and de-puffing agent, characterized by, The raw materials include the following weight parts: 5-15 parts of a eutectic solvent, 1-5 parts of moisturizing and swelling microspheres, 2-4 parts of panthenol, 0.1-0.4 parts of carbomer, 4-8 parts of glycerol, and 0.5-1 part of phenoxyethanol; The eutectic solvent includes the following mass ratio of raw materials: L-menthol: capric acid = 1:1-1.5; The preparation method of the eutectic solvent includes the following steps: Weigh L-menthol and capric acid, mix, stir in a constant temperature water bath, form a uniform liquid, stand and cool, and obtain the eutectic solvent.

2. The skin care moisturizing de-puffing agent according to claim 1, wherein The moisturizing and swelling microspheres include the following mass ratio of raw materials: hydrogenated lecithin: caffeine: esculin: sodium alginate: sodium hyaluronate: glycerol = 2-3:4:1:10:2:30-50; The preparation method of the moisturizing and swelling microspheres includes the following steps: (a) Weigh hydrogenated lecithin, caffeine and esculin, add caprylic triglyceride as an oil phase carrier, stir in a constant temperature water bath, and form an oil phase solution; (b) Weigh sodium alginate, sodium hyaluronate and glycerol, add deionized water, and magnetically stir to form a shell water phase solution; (c) Slowly drop the oil phase solution prepared in step (a) into the shell water phase solution prepared in step (b) under shearing, continue to shear, and form a primary emulsion; (d) Take calcium chloride, prepare a calcium chloride aqueous solution, drop the primary emulsion obtained in step (c) into the calcium chloride solution, stir, and form solidified core-shell microspheres; (e) Allow the core-shell microspheres to naturally settle, collect the settled microspheres, wash, obtain a wet product of the core-shell structure microsphere compound, freeze-dry, and obtain the moisturizing and swelling microspheres.

3. The skin care moisturizing de-puffing agent of claim 2, wherein the skin care moisturizing de-puffing agent is a skin care moisturizing de-puffing agent for the eye area. In step (a), the mass ratio of caprylic triglyceride to hydrogenated lecithin is 10-20:1; In step (b), the amount ratio of deionized water to sodium alginate is 100-200 mL:1 g; In step (c), the volume ratio of the oil phase solution to the shell water phase solution is 1:4-6.

4. A process for the preparation of a skin care moisturizing de-puffing agent according to any one of claims 1 to 3, characterized in that, Specifically includes the following steps: S1, take the eutectic solvent, add panthenol, stir, and obtain an active concentrate; S2, disperse carbomer in deionized water, stir at high speed until swelling, add glycerol, stir at low speed, form a water phase matrix, then slowly add the active concentrate to the water phase matrix, add the moisturizing and swelling microspheres, homogenize, and form a composite system; S3, add triethanolamine to the composite system dropwise to adjust the pH value, then add phenoxyethanol, stir uniformly at low speed, stand to defoam, discharge, and obtain the skin care moisturizing and swelling agent.

5. The preparation method of the skin care moisturizing and anti-swelling agent according to claim 4, characterized in that, In step S2, the amount ratio of deionized water to carbomer is 50 mL:1 g.

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