Compound medicine formula for resisting allergy and enhancing immunity

Abstract

The invention discloses a compound medicine formula for resisting allergy and enhancing immunity. The compound medicine formula is prepared from the following raw materials in parts by weight: radix bupleuri; cortex moutan; chinese angelica; earthworms; wind prevention; fructus mume; chinese magnoliavine fruit; radix astragali; cynanchum paniculatum; lemna minor; vines of multiflower knotweed; periostracum cicada; liquorice; fructus kochiae; cortex dictamni; radix paeoniae rubra; gentiana macrophylla; rhizoma atractylodis; tribulus terrestris; herba ephedrae and herba schizonepetae; radix rehmanniae recen; the invention relates to the technical field of composite medicines, according to the formula of the composite medicine, multiple traditional Chinese medicinal materials are scientifically proportioned, and the dual effects of efficient anti-allergy and immunoregulation are achieved; the radix bupleuri, the cortex moutan, the angelica sinensis and other components in the formula have the effects of dispelling wind, relieving exterior syndrome and regulating ying and wei, and can quickly relieve skin itch, redness and swelling and other symptoms caused by allergy; the ingredients such as the astragalus membranaceus and the schisandra chinensis can tonify qi and strengthen superficies, enhance the immunity of the organism and improve the tolerance to allergens. Meanwhile, the formula adopts natural traditional Chinese medicinal materials and is small in side effect, high in safety and suitable for long-term use.

Description

Technical Field

[0001] This invention relates to the field of compound drug technology, specifically to a compound drug formulation for anti-allergy and immune enhancement. Background Technology

[0002] Allergic diseases are among the most common chronic diseases worldwide, affecting approximately 30% of the global population. Allergic reactions are closely related to abnormal responses of the body's immune system. When the body comes into contact with an allergen, the immune system mistakes it for a harmful substance, triggering a series of immune responses that lead to allergic symptoms. Common allergy symptoms include itchy, red, and swollen skin, sneezing, runny nose, and asthma, severely impacting patients' quality of life.

[0003] Currently, treatments for allergic diseases mainly include avoiding allergens, using antihistamines, and corticosteroids. However, these methods mostly only relieve symptoms and cannot fundamentally solve the allergy problem. Furthermore, long-term use of antihistamines and corticosteroids may produce side effects such as drowsiness, dry mouth, and weight gain.

[0004] On the other hand, strengthening the body's immunity is one of the important means of preventing and treating allergic diseases. The immune system is a key line of defense for the body against pathogens and maintaining its own homeostasis. A healthy immune system can effectively identify and eliminate allergens, reducing the occurrence of allergic reactions. However, most existing immunomodulatory drugs have limited efficacy and certain safety and tolerability issues.

[0005] Therefore, developing a compound drug formulation that can effectively combat allergies and enhance immunity is of great significance for improving the symptoms and quality of life of patients with allergic diseases. An ideal compound drug formulation for both allergy relief and immune enhancement should possess the following characteristics: Highly effective against allergies: It can quickly relieve allergy symptoms and reduce the occurrence of allergic reactions.

[0006] Immune regulation: It can enhance the body's immunity and increase the body's tolerance to allergens.

[0007] High safety: Natural ingredients, few side effects, suitable for long-term use.

[0008] Wide range of applications: Suitable for different types of allergic diseases, including but not limited to skin allergies, respiratory allergies and food allergies.

[0009] However, there is currently no compound drug formulation that can simultaneously meet all of the above requirements in the existing technology.

[0010] Therefore, the present invention aims to provide a compound drug formulation that combines anti-allergy and immune enhancement, offering a safe and effective treatment option for patients with allergic diseases. Summary of the Invention

[0011] To address the shortcomings of existing technologies, this invention provides a compound drug formulation for both anti-allergy and immune enhancement, solving the problem that existing technologies cannot optimize drug components and ratios to achieve both highly effective anti-allergy and immune-regulating effects.

[0012] To achieve the above objectives, the present invention is implemented through the following technical solution: a compound drug formula for anti-allergy and immune enhancement, made from the following raw materials in the indicated weight ratios: Bupleurum chinense 10 parts; Paeonia suffruticosa 10 parts; Angelica sinensis 10 parts; Pheretima aspergillum 10 parts; Saposhnikovia divaricata 10 parts; Prunus mume 10 parts; Schisandra chinensis 6 parts; Astragalus membranaceus 20 parts; Cynanchum paniculatum 15 parts; Lemna minor 6 parts; Polygonum multiflorum vine 30 parts; Cicadae periostracum 6 parts; Glycyrrhiza uralensis 10 parts; Kochia scoparia 20 parts; Dictamnus dasycarpus 20 parts; Paeonia lactiflora 20 parts; Gentiana macrophylla 10 parts; Atractylodes lancea 10 parts; Tribulus terrestris 15 parts; Ephedra sinica 5 parts; Schizonepeta tenuifolia 10 parts; Rehmannia glutinosa 20 parts; Lonicera japonica 20 parts.

[0013] Preferably, the formulation is prepared as a decoction, granules, capsules, tablets, or oral liquid.

[0014] Preferably, the formulation is used to prepare a drug for treating allergic rhinitis, urticaria, eczema, and diseases related to immunodeficiency.

[0015] Preferably, the formulation further includes pharmaceutically acceptable excipients, which are one or more of dextrin, microcrystalline cellulose, sodium carboxymethyl starch, and magnesium stearate.

[0016] Preferably, the formulation is used to prepare a seasonal allergy prevention medication, which is taken starting two weeks before the allergy season.

[0017] Preferably, the earthworm in the formula is *Earthworm spp.*

[0018] Preferably, the cicada molting in the formula is golden cicada exuviae.

[0019] Beneficial effects This invention provides a compound drug formulation for anti-allergy and immune enhancement, which has the following beneficial effects: This compound drug formula, through a scientific ratio of various traditional Chinese medicinal herbs, achieves the dual effects of highly effective anti-allergy and immune regulation. Ingredients such as Bupleurum, Moutan Bark, and Angelica have the functions of dispelling wind and releasing the exterior, and harmonizing the body's vital energy and defenses, which can quickly relieve symptoms such as itching and redness caused by allergies. Ingredients such as Astragalus and Schisandra can invigorate qi and strengthen the exterior, enhance the body's immunity, and improve tolerance to allergens. At the same time, the formula uses natural Chinese medicinal herbs, has few side effects, high safety, and is suitable for long-term use.

[0020] In addition, this compound drug formula has a wide range of applications. It can be used not only to treat common allergic diseases such as allergic rhinitis, urticaria, and eczema, but also as an adjunct treatment for diseases related to low immune function, as well as a preventive medication for seasonal allergies, providing a safe and effective treatment option for patients with allergic diseases. Detailed Implementation

[0021] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0022] This invention provides a technical solution: a compound drug formula for anti-allergy and immune enhancement, made from the following raw materials in the indicated weight ratios: Bupleurum chinense 10 parts; Paeonia suffruticosa 10 parts; Angelica sinensis 10 parts; Pheretima aspergillum 10 parts; Saposhnikovia divaricata 10 parts; Prunus mume 10 parts; Schisandra chinensis 6 parts; Astragalus membranaceus 20 parts; Cynanchum paniculatum 15 parts; Lemna minor 6 parts; Polygonum multiflorum vine 30 parts; Cicadae periostracum 6 parts; Glycyrrhiza uralensis 10 parts; Kochia scoparia 20 parts; Dictamnus dasycarpus 20 parts; Paeonia lactiflora 20 parts; Gentiana macrophylla 10 parts; Atractylodes lancea 10 parts; Tribulus terrestris 15 parts; Ephedra sinica 5 parts; Schizonepeta tenuifolia 10 parts; Rehmannia glutinosa 20 parts; Lonicera japonica 20 parts; The above formula can immediately relieve allergies by inhibiting mast cell degranulation and blocking histamine receptors: the alkaloids of Xu Changqing, Difuzi, Baixianpi, and Kushen can dose-dependently reduce serum IgE, competitively antagonize H1 receptors, and quickly relieve sneezing, hives, and itching. To achieve immune rebalancing, namely upregulating IgG / IgA and correcting Th1 / Th2 drift: Astragalus polysaccharides, bupleurum saponins, and angelica polysaccharides activate Toll-like receptors, promote IFN-γ secretion, inhibit Th2 overpolarization, and increase the CD4+ / CD8+ ratio and Th1 / Th2 ratio, respectively. Ginsenosides (Schisandra chinensis and licorice) stimulate the maturation of bone marrow B cells, significantly increasing serum IgG and IgA levels, and have the effect of tonifying qi and consolidating the exterior in the case of recurrent respiratory infections and the "prolonged illness and deficiency" state of eczema. Anti-inflammatory and barrier repair, namely, scavenging free radicals and promoting skin keratinization: Paeoniflorin, Paeoniflorin, and Rehmannia polysaccharide inhibit the NF-κB pathway, downregulate TNF-α and IL-6, and reduce inflammatory infiltration of the nasal mucosa and dermis. Polygonum multiflorum vine, Angelica sinensis, and Rehmannia glutinosa are rich in styrene and ferulic acid, which can upregulate the expression of Filaggrin and Loricrin, repair the skin's physical barrier, and reduce transepidermal water loss. Microcirculation and itch relief, namely promoting blood circulation and dispelling wind + calming neuropeptides: earthworm protein and ligustrazine-like components (angelica and red peony) improve the microcirculation of the nasal turbinates and dermis, accelerate the absorption of exudate, and shorten the duration of urticaria wheals. Xu Changqing paeonol and schisandra lignans produce a dual antipruritic effect in the central and peripheral systems by regulating the balance of substance P / endorphin, and the patient's subjective VAS itch is reduced.

[0023] In this embodiment, the formula is further configured to be prepared into a decoction, granules, capsules, tablets, or oral liquid; This can expand the actual effectiveness of this formula.

[0024] In this embodiment, the formulation is further configured to be used to prepare drugs for treating allergic rhinitis, urticaria, eczema, and diseases related to immunodeficiency.

[0025] This embodiment is further configured such that the formulation also includes pharmaceutically acceptable excipients, wherein the excipients are one or more of dextrin, microcrystalline cellulose, sodium carboxymethyl starch, and magnesium stearate; For preparation into granules, add appropriate amounts of dextrin and microcrystalline cellulose as excipients to the extract, mix evenly, and then granulate using a wet granulation machine. After drying, package the granules. For preparation into capsules, further dry the extract into a dry powder, add excipients such as sodium carboxymethyl starch and magnesium stearate, mix evenly, and then fill the capsule shells. For preparation into tablets, add appropriate amounts of excipients to the dry powder and compress it into tablets using a tableting machine. For preparation into oral liquid, add appropriate amounts of preservatives and sweeteners to the extract, adjust the taste, fill into oral liquid bottles, and sterilize.

[0026] In this embodiment, the formula is further configured to prepare a seasonal allergy prevention medication, which is taken starting two weeks before the allergy season.

[0027] In this embodiment, the earthworm in the formula is *Earthworm var. *guangdilong*. Earthworm has a better effect on clearing the meridians, which can enhance the overall effect of the medicine in clearing the meridians and activating blood circulation and anti-allergy, and help improve allergy symptoms caused by poor meridian circulation and stagnation of qi and blood.

[0028] In this embodiment, the cicada molt in the formula is a golden cicada exuviae; Cicada molts are light and thin in texture and have pure medicinal effects. Compared with ordinary cicada molts, they have a more significant effect in dispersing wind-heat and relieving itching and rashes. They can effectively relieve symptoms such as skin itching and hives caused by allergies and enhance the anti-allergy effect of drugs.

[0029] Example: Weigh the raw materials according to the following parts by weight: Bupleurum chinense 10 parts; Moutan bark 10 parts; Angelica sinensis 10 parts; Earthworm 10 parts; Saposhnikovia divaricata 10 parts; Mume 10 parts; Schisandra chinensis 6 parts; Astragalus membranaceus 20 parts; Cynanchum paniculatum 15 parts; Duckweed 6 parts; Polygonum multiflorum vine 30 parts; Cicada slough 6 parts; Licorice 10 parts; Kochia scoparia 20 parts; Dictamnus dasycarpus 20 parts; Paeonia lactiflora 20 parts; Gynostemma pentaphyllum 10 parts; Atractylodes lancea 10 parts; Tribulus terrestris 15 parts; Ephedra sinica 5 parts; Schizonepeta tenuifolia 10 parts; Rehmannia glutinosa 20 parts; Lonicera japonica 20 parts; After mixing the above raw materials, the effective components are extracted by decoction. The specific operation is as follows: place the mixed raw materials in a clay pot, add water with a total weight of 8 to 10 times the weight of the raw materials, soak for 30 minutes, bring to a boil over high heat, then simmer over low heat for 40 to 60 minutes, and filter out the liquid; add water with a total weight of 6 to 8 times the weight of the raw materials to the dregs again, and decoct for 30 to 40 minutes in the same way, and filter out the liquid; combine the two liquids and concentrate to a clear paste with a relative density of 1.1 to 1.2; If it is necessary to prepare it into granules, add an appropriate amount of dextrin and microcrystalline cellulose as excipients to the clear paste, mix it evenly, and then granulate it by wet granulation. After drying, it can be packaged. If it is necessary to prepare it into capsules, the clear paste is further dried into dry paste powder, and excipients such as sodium carboxymethyl starch and magnesium stearate are added. After mixing evenly, the mixture is filled into capsule shells. If tablets are required, add an appropriate amount of excipients to the dry extract powder and compress it into tablets using a tableting machine. If it needs to be prepared into an oral liquid, add an appropriate amount of preservatives, sweeteners, etc. to the paste to adjust the taste, then fill it into oral liquid bottles and sterilize it.

[0030] During the preparation process, Bupleurum can be selected from those with thick, firm rhizomes and rich aroma to ensure that the content of its effective ingredient, saikosaponin, meets the standard; Paeonia suffruticosa can be selected from those with thick skin, plump flesh, and reddish-brown cross-section to ensure sufficient active ingredients such as paeonol; Angelica sinensis can be selected from those with thick, long, oily main roots and strong aroma.

[0031] In the decoction process, precise control of heat and time affects the extraction rate of the active ingredients in the medicine: during the high-heat boiling stage, the temperature inside the pot must be raised quickly to allow the components in the raw materials to be released into the water rapidly; when simmering over low heat, a gentle boil should be maintained to avoid destroying the active ingredients due to excessive heat; the time arrangement for the two decoctions is set according to the solubility characteristics of different components in water. The first long decoction can fully extract most of the water-soluble components, while the second shorter decoction can further extract the remaining active substances.

[0032] In clinical application, the dosage and course of treatment of this compound drug formula vary depending on the type of allergic disease. For patients with mild allergic rhinitis, granules or capsules can be taken twice a day initially, with the dosage adjusted appropriately according to the condition. After taking it for a week, the improvement of symptoms should be observed. If the symptoms are significantly relieved, the dosage can be gradually reduced to once a day for maintenance treatment. For patients with refractory urticaria, it may be necessary to use oral liquid and tablets in combination to enhance the anti-allergic and immunomodulatory effects of the drug. The course of treatment is usually two to three weeks.

[0033] To ensure medication safety, patients should avoid spicy, greasy, and irritating foods, as well as potentially allergenic foods such as seafood, while taking this compound medication. If mild discomfort occurs during medication, such as gastrointestinal reactions, the dosage time can be adjusted, or the medication can be taken after meals to alleviate symptoms. If severe adverse reactions occur, medication should be discontinued immediately and medical attention sought. Furthermore, pregnant women, breastfeeding women, and patients with serious chronic diseases should consult their doctor before using this medication.

[0034] It should be noted that, in this document, relational terms such as "first" and "second" are used merely to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitations, the phrase "comprising an element defined as..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes said element.

[0035] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A complex pharmaceutical formulation for anti-allergy and immunity enhancement, characterized in that, It is made of the following raw materials in the weight parts: Radix Bupleuri 10 parts; Radix Stephaniae Tetrandrae 10 parts; Radix Angelicae Sinensis 10 parts; Earthworm 10 parts; Saposhnikovia Divaricata 10 parts; Fructus Mume 10 parts; Schisandra Chinensis 6 parts; Radix Astragali 20 parts; Xu Changqing 15 parts; Salvinia natans 6 parts; Radix Polygoni Multiflori 30 parts; Cicada Slough 6 parts; Radix Glycyrrhizae 10 parts; Fructus Tribuli 20 parts; Cortex Dictamni 20 parts; Radix Paeoniae Rubra 20 parts; Rhizoma Coptidis 10 parts; Radix Atractylodis 10 parts; Fructus Alhagi 15 parts; Ephedra 5 parts, Schizonepeta 10 parts; Radix Rehmanniae 20 parts; Lonicera Japonica 20 parts.

2. The complex pharmaceutical formulation for anti-allergy and immunity enhancement according to claim 1, wherein The formula is prepared into decoction, granules, capsules, tablets or oral liquid.

3. The compound drug formulation for anti-allergy and immune enhancement according to claim 1, characterized in that, The formula is used for preparing medicine for treating allergic rhinitis, urticaria, eczema and diseases related to low immune function.

4. The compound drug formulation for anti-allergy and immune enhancement according to claim 1, characterized in that, The formula further comprises pharmaceutically acceptable adjuvant, which is one or more of dextrin, microcrystalline cellulose, sodium carboxymethyl starch and magnesium stearate.

5. The complex pharmaceutical formulation for anti-allergy and immunity enhancement according to claim 1, wherein The formula is used for preparing medicine for preventing seasonal allergy, which is taken 2 weeks before the allergic season.

6. The complex pharmaceutical formulation for anti-allergy and immunity enhancement according to claim 1, wherein The earthworm in the formula is broad earthworm.

7. The complex pharmaceutical formulation for anti-allergy and immunity enhancement according to claim 1, wherein the said formulation is in the form of a tablet, capsule, syrup, powder, granule, or the like. The cicada slough in the formula is golden cicada slough.