Traditional Chinese medicine composition for simultaneously reducing systolic pressure and diastolic pressure as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention discloses a traditional Chinese medicine composition for simultaneously reducing systolic pressure and diastolic pressure as well as a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw material medicines: 15-20 parts of radix rehmanniae recen, 10-20 parts of Chinese yam, 10-20 parts of pulp of dogwood fruit, 20-30 parts of astragalus membranaceus, 15-30 parts of kudzu vine root, 12-15 parts of gastrodia elata, 12-15 parts of uncaria rhynchophylla, 30-50 parts of oyster, 20-30 parts of concha haliotidis, 15-30 parts of poria cocos, 15-30 parts of rhizoma alismatis and 9-15 parts of moutan bark. The traditional Chinese medicine composition is prepared by composite compatibility of yin-nourishing, liver-calming and qi-tonifying medicines aiming at common composite pathogenesis of kidney yin deficiency, liver-yang hyperactivity and qi deficiency type hypertension of middle-aged and elderly patients, all the components have a synergistic effect, and experimental results show that the traditional Chinese medicine composition has an obvious antihypertensive effect on systolic pressure and diastolic pressure, and can be used for treating both systolic pressure and diastolic pressure. Compound symptoms such as dizziness, headache, weakness, soreness and weakness of waist and knees, dry mouth and the like can be improved while blood pressure is reduced, and toxic and side effects are avoided.

Description

TECHNICAL FIELD

[0001] The application belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for simultaneously reducing systolic pressure and diastolic pressure as well as a preparation method and application thereof. BACKGROUND

[0002] Primary hypertension, also known as hypertension, is a clinical syndrome characterized by increased arterial blood pressure in the systemic circulation (systolic pressure ≥ 140 mmHg and / or diastolic pressure ≥ 90 mmHg), which can be accompanied by functional or organic damage to the heart, brain, kidney and other organs. The pathogenesis of hypertension involves multiple systems such as nerves, endocrine and immune systems, and is believed to be caused by the combined effects of genetics and environmental factors. Some scholars have summarized the pathogenesis of hypertension by summarizing literature, which mainly includes activation of the renin-angiotensin system (RAS), inflammation in some cells and organs, increase in oxidative stress and changes in total antioxidant capacity, vascular endothelial cell dysfunction, and changes in intestinal flora.

[0003] The pathogenesis of hypertension involves multiple systems of the human body, and traditional Chinese medicine compounds can control blood pressure by simultaneously acting on multiple pathways due to their complex components. Traditional Chinese medicine compounds gradually show their advantages in controlling blood pressure. According to clinical practice, traditional Chinese medicine divides hypertension into the following types: liver yang hyperactivity type, phlegm-dampness obstruction type, qi stagnation and blood stasis type, liver-kidney yin deficiency type, heart and spleen deficiency type, yin deficiency and yang hyperactivity type, and qi deficiency and blood stasis type.

[0004] In the process of clinical practice, it is found that patients with hypertension often have symptoms such as headache, dizziness, soreness in the waist, dry mouth, fatigue, and irritability, and the age of onset of hypertension is mostly in the middle and old age, at which time the body organs gradually decline, and liver-kidney yin deficiency and spleen qi deficiency are often seen together. Traditional Chinese medicine treatment of hypertension often focuses on single syndrome type, such as pure yin or pure liver calming, which cannot cover the treatment of complex syndrome type. SUMMARY

[0005] In view of the deficiencies of the prior art, the purpose of the present application is to provide a traditional Chinese medicine composition for simultaneously reducing systolic pressure and diastolic pressure. The composition is aimed at the complex pathogenesis of kidney yin deficiency, liver yang hyperactivity and qi deficiency type existing in middle-aged and elderly patients with hypertension, and has obvious antihypertensive effect on systolic pressure and diastolic pressure through the synergistic combination of various components. The composition can improve complex symptoms such as dizziness, headache, fatigue, soreness in the waist and knees, and dry mouth while reducing blood pressure.

[0006] The present application is realized by the following technical solutions: The application provides a traditional Chinese medicine composition for simultaneously reducing systolic pressure and diastolic pressure, which is prepared from the following raw materials in parts by weight: 15-20 parts of radix rehmanniae, 10-20 parts of radix polygonati, 10-20 parts of fructus corni, 20-30 parts of radix astragali, 15-30 parts of radix puerariae, 12-15 parts of gastrodia, 12-15 parts of Uncaria, 30-50 parts of concha mallei, 20-30 parts of concha haliotidis, 15-30 parts of poria, 15-30 parts of almus, and 9-15 parts of cortex moutan.

[0007] As a further preferred technical solution, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 15 parts of radix rehmanniae, 15 parts of radix polygonati, 12 parts of fructus corni, 20 parts of radix astragali, 20 parts of radix puerariae, 12 parts of gastrodia, 12 parts of Uncaria, 30 parts of concha mallei, 20 parts of concha haliotidis, 20 parts of poria, 15 parts of almus, and 9 parts of cortex moutan.

[0008] The medicinal mechanisms of the raw materials of the traditional Chinese medicine composition are as follows: Radix rehmanniae is sweet, bitter and cold, and is attributed to heart, liver and kidney channels, and has the functions of clearing heat and cooling blood, nourishing yin and generating fluid. Modern pharmacological studies show that the main active components contain catalpol (up to 2%~5%), which has the effects of nerve protection, anti-inflammation, blood glucose reduction, and anti-myocardial ischemia; leucopelargonidin has the effects of anti-oxidation and microcirculation improvement; onjisaponin has the effects of anti-liver injury and tissue repair promotion; and rehderioside has the effects of immune regulation and hematopoietic function.

[0009] Radix polygonati is sweet and flat, and is attributed to spleen, lung and kidney channels, and has the functions of benefiting qi and nourishing yin, and tonifying spleen, lung and kidney. Modern pharmacological studies show that the main active components contain polygonatum polysaccharide, which has the effects of immune regulation, pancreatic beta cell protection, anti-oxidation and anti-aging; and dioscin has the effects of anti-tumor, blood lipid reduction and anti-atherosclerosis.

[0010] Fructus corni is sour and slightly warm, and is attributed to liver and kidney channels, and has the functions of tonifying liver and kidney and astringing and contracting. Modern pharmacological studies show that the main active components contain loganin, which has the effects of nerve protection, anti-inflammation and insulin secretion promotion; and kaempferol has the effect of anti-atherosclerosis.

[0011] Radix astragali is sweet and slightly warm, and is attributed to spleen and lung channels, and has the functions of tonifying qi and raising yang, benefiting defense and stabilizing exterior, promoting toxin discharge and generating muscle, and promoting water discharge and reducing swelling. Modern pharmacological studies show that it contains multiple active components, which have the effects of immune regulation, anti-inflammation and anti-oxidation. Among them, astragaloside A is the core component, which has the effects of anti-fibrosis, anti-myocardial hypertrophy, heart function improvement and cell aging delay.

[0012] Radix Puerariae, sweet, pungent, cool, and meridian of spleen and stomach, has the functions of releasing the exterior, promoting the Yang and eliminating heat. Modern pharmacological studies have shown that it is rich in various active ingredients, with cardiovascular protection, antioxidant, and liver protection. Among them, puerarin, with the highest content (about 1%~12%), has the effects of expanding coronary artery, improving myocardial ischemia, and reducing blood pressure (inhibiting RAAS system).

[0013] Gastrodia elata, sweet and flat, and meridian of liver, has the functions of calming wind and relieving convulsion, and calming the liver and suppressing the Yang. Modern pharmacological studies have shown that it contains various active ingredients, with neuroprotection, sedation, and antiepileptic effects. Among them, gastrodin, with the highest content (about 0.3%~1.2%), has the effects of reducing cerebral ischemia-reperfusion injury, improving Alzheimer's disease, protecting vascular endothelial cells, and anti-inflammatory.

[0014] Uncaria, sweet and slightly cold, and meridian of liver and pericardium, has the functions of calming wind and relieving convulsion, and clearing heat and calming the liver. Modern pharmacological studies have shown that it is rich in various alkaloids, with antihypertensive, neuroprotective, and antithrombotic effects. Among them, uncarine has the effects of blocking calcium channels, dilating blood vessels, and inhibiting the RAAS system; iso-uncarine has the effects of inhibiting TXA2 production and preventing thrombosis.

[0015] Ostrea, salty and slightly cold, and meridian of liver and kidney, has the functions of calming the liver and suppressing the Yang, dispersing and resolving, and astringing. Modern pharmacological studies have shown that it is rich in various inorganic and organic active ingredients, with antioxidant, immunomodulatory, and neuroprotective effects. Among them, the main component of ostrea active peptide has the effect of inhibiting ACE (angiotensin converting enzyme), similar to the antihypertensive effect of captopril, and also has neuroprotective and anti-fatigue effects.

[0016] Concha Haliotidis, salty and cold, and meridian of liver, has the functions of calming the liver and suppressing the Yang, and clearing the liver and improving eyesight. Modern pharmacological studies have shown that it is rich in inorganic and organic active ingredients, with antihypertensive, antioxidant, and neuroprotective effects. Among them, taurine has the effects of neuroprotection and osmotic pressure regulation; sulfated polysaccharides have the effects of inhibiting platelet aggregation and immunomodulation; taurine and glycine have the effects of synergistic sedation and neuroprotection; calcium carbonate and sulfated polysaccharides have the effects of synergistic regulation of calcium metabolism and hemorheology.

[0017] Poria cocos, sweet and bland, and meridian of heart, spleen, and kidney, has the functions of promoting water and removing dampness, tonifying the spleen, and tranquilizing the mind. Modern pharmacological studies have shown that it is rich in polysaccharides and triterpenes, with diuretic, immunomodulatory, and antitumor effects. Among them, pachymic acid has the effects of inhibiting COX-2 and iNOS expression, reducing arthritis, and neuroprotection; and tomoxic acid has the effects of inhibiting renal tubular Na⁺-K⁺-ATPase and promoting water and sodium excretion.

[0018] Alisma plantago-aquatica, sweet, bland, and cold in nature, enters the kidney and bladder meridians, and has the functions of promoting diuresis and eliminating dampness, and clearing heat. Modern pharmacological studies have shown that it is rich in triterpenoids, polysaccharides, and other active ingredients, and has diuretic, lipid-lowering, and anti-inflammatory effects. Among them, alismaol A, B, and C have the effect of inhibiting renal tubular Na⁺ reabsorption and activating the PPARα pathway to promote fatty acid β-oxidation (lowering TG and LDL-C).

[0019] Moutan bark, bitter, pungent, and cold in nature, enters the heart, liver, and kidney meridians, and has the functions of clearing heat and cooling blood, promoting blood circulation and removing blood stasis. Modern pharmacological studies have shown that it is rich in monoterpenoid glycosides, phenols, and other active ingredients, and has anti-inflammatory, antioxidant, and neuroprotective effects. Its main component, paeonol, can inhibit the NF-κB pathway, reduce TNF-α and IL-6 levels, dilate coronary arteries, improve myocardial ischemia (Ca²⁺ channel blockade), and inhibit Aβ protein aggregation.

[0020] In the above-mentioned traditional Chinese medicine composition, Rehmannia glutinosa, Dioscorea opposita, and Cornus officinalis are the principal herbs, nourishing the kidneys and liver, generating marrow and benefiting the brain; Astragalus membranaceus and Pueraria lobata are the assistant herbs, strengthening the spleen and promoting the upward flow of qi to nourish the brain; Gastrodia elata, Uncaria rhynchophylla, Ostrea gigas, and Haliotis diversicolor calm the liver and extinguish wind; Poria cocos, Alisma plantago-aquatica, and Paeonia suffruticosa are the adjuvant herbs, promoting diuresis and eliminating turbidity. The entire formula harmonizes the liver, kidneys, and spleen, and has the effects of nourishing the liver and kidneys, replenishing qi and promoting the upward flow of qi, and calming the liver and eliminating turbidity.

[0021] This invention targets the fundamental pathogenesis of kidney yin deficiency, adding Rehmannia glutinosa, Dioscorea opposita, Cornus officinalis, Poria cocos, Alisma plantago-aquatica, and Paeonia suffruticosa to achieve the effect of nourishing yin and tonifying the kidneys. For hypertension, dizziness, and headache caused by liver yang hyperactivity, Gastrodia elata, Uncaria rhynchophylla, Ostrea gigas, and Haliotis diversicolor are added to directly calm the liver and lower blood pressure. For the qi deficiency often present in hypertensive patients (such as fatigue, worsening dizziness, and large fluctuations in blood pressure), Astragalus membranaceus and Pueraria lobata are added. Astragalus membranaceus enhances the kidney-tonifying and vital energy-strengthening effects of Dioscorea opposita and Cornus officinalis, while Pueraria lobata assists the blood-circulating and blood pressure-lowering effects of Gastrodia elata and Uncaria rhynchophylla. By tonifying qi, the body's regulatory capacity is improved, thus both assisting in lowering blood pressure and alleviating qi deficiency-related symptoms, avoiding the physical weakness caused by simply lowering blood pressure. The synergistic combination of these components achieves bidirectional regulation of systolic and diastolic blood pressure, taking into account both the regulation of internal organs and the control of blood pressure.

[0022] The present invention also provides a method for preparing the above-mentioned traditional Chinese medicine composition, comprising the following steps: (1) Soak oysters and abalone shells in water and then decoct for 20-30 minutes to obtain a decoction; (2) Soak all raw materials except oysters and abalone shells in water to obtain a soaking mixture; (3) Add the soaking mixture to the decoction and continue to decoct twice, 30-60 minutes each time. Filter, combine the filtrates, concentrate and obtain the final product.

[0023] As a further preferred technical solution, in step (1), the soaking time of the oysters and abalone shells in water is 20-60 minutes. Add water at 2-5 times the volume for 1 minute.

[0024] As a further preferred technical solution, in step (2), the water soaking time of the other raw materials is 20-60 minutes, and the water amount is 1-3 times.

[0025] The application also provides application of the above-mentioned traditional Chinese medicine composition in preparation of a medicine for treating complex syndrome type hypertension.

[0026] The complex syndrome type hypertension according to the application is kidney-yin deficiency, liver-yang hyperactivity and qi deficiency type hypertension.

[0027] The traditional Chinese medicine composition according to the application can simultaneously reduce systolic pressure and diastolic pressure, and improve symptoms of fatigue and soreness of waist and knees.

[0028] The medicine according to the application comprises an effective amount of the traditional Chinese medicine composition and a pharmaceutically acceptable carrier. The pharmaceutically acceptable carrier according to the application includes, but is not limited to, disintegrants, lubricants, binders, penetration enhancers, plasticizers, antioxidants, preservatives and the like.

[0029] The medicine according to the application can be prepared into any common dosage form according to conventional traditional Chinese medicine preparation methods, including, but not limited to, oral administration dosage forms, injection administration dosage forms or external administration preparation, such as decoction, tablets, capsules, granules, pills, injections, decocted paste, suspensions, dispersions, syrup, suppositories, gels, aerosols, patches or oral liquids and the like.

[0030] The traditional Chinese medicine composition for simultaneously reducing systolic pressure and diastolic pressure prepared according to the application is used by oral administration 2-3 times per day, and each time 100-200 ml (water decoction).

[0031] Compared with the prior art, the application has the following advantages: The traditional Chinese medicine composition according to the application is aimed at kidney-yin deficiency, liver-yang hyperactivity and qi deficiency type hypertension, which is a common complex pathogenesis of middle-aged and elderly patients. The composition is prepared by compounding tonifying yin, soothing liver and tonifying qi medicines, and the components are synergistically combined. Experimental results show that the traditional Chinese medicine composition according to the application has obvious antihypertensive effect on systolic pressure and diastolic pressure, and can improve complex symptoms such as dizziness, headache, fatigue, soreness of waist and knees, dry mouth and the like at the same time, and has no toxic and side effects. DETAILED DESCRIPTION

[0032] The technical solutions of the application will be described clearly and completely in combination with the embodiments of the application. The described embodiments are only some of the embodiments of the application, rather than all the embodiments. Based on the embodiments in the application, all other embodiments obtained by those skilled in the art without creative efforts fall within the protection scope of the application.

[0033] The test materials used in the embodiments of the present application are all conventional test materials in the art and can be purchased through commercial channels. Example 1

[0034] A traditional Chinese medicine composition for simultaneously reducing systolic and diastolic blood pressure is prepared from the following raw materials in parts by weight: Rehmannia 15 parts, Dioscorea 15 parts, Cornus 12 parts, Astragalus 20 parts, Pueraria 20 parts, Gastrodia 12 parts, Uncaria 12 parts, Oyster 30 parts, Concha Murex 20 parts, Poria 20 parts, Alisma 15 parts, and Cortex Moutan 9 parts.

[0035] The preparation process is as follows: (1) Oyster and Concha Murex are soaked in 5 times the amount of water for 40 minutes, and decocted for 30 minutes to obtain a first decoction; (2) The other raw materials except Oyster and Concha Murex are soaked in 2 times the amount of water for 30 minutes to obtain a soaking mixture; (3) The soaking mixture is added to the first decoction and decocted twice, each time for 30 minutes, filtered, the filtrates are combined, and concentrated to obtain the product.

[0036] Test Example 1: Clinical observation of the antihypertensive effect of the traditional Chinese medicine composition for simultaneously reducing systolic and diastolic blood pressure of the present application.

[0037] This study was approved by the Second Affiliated People's Hospital of Fujian University of Chinese Medicine (Ethics Approval No.: SPHFJP-K2024001-01); Case data: 29 outpatients with hypertension were selected, with a treatment course of 2-4 weeks. Among the selected patients, 20 were male and 9 were female, aged 38-65 years, with an average age of 48.48±8.63.

[0038] Treatment method: All selected patients were first discovered to have hypertension or had poor treatment effect after oral administration of western antihypertensive drugs, and only took the water decoction of the traditional Chinese medicine composition of the present application during the treatment period. The water decoction was extracted by heating to a concentration of 0.5g / ml, 200ml each time, and taken 40 minutes after breakfast and dinner every day.

[0039] Statistical method: Graphpad Prism 8 was used to statistically analyze the blood pressure of the patients, and the mean value±SD was used for representation. Paired t-test was used for statistical analysis for normal distribution, and rank sum test was used for analysis for non-normal distribution. P value <0.05 represents significant difference.

[0040] Results: The clinical symptoms of all patients in the group were as follows: 22 cases of dizziness, 10 cases of headache, 20 cases of fatigue, 25 cases of soreness of the waist, 20 cases of dry mouth, and 20 cases of insomnia. After treatment, the symptoms were significantly improved, as shown in Table 1.

[0041] Table 1 Improvement of symptoms of all patients before and after treatment

[0042] The systolic and diastolic blood pressures of the enrolled patients were significantly decreased after treatment, as shown in Table 2.

[0043] Table 2 Changes in blood pressure before and after treatment

[0044] As can be seen from the results in Table 2, the clinical symptoms and systolic and diastolic blood pressures of the 29 patients included were significantly improved after taking the decoction of the traditional Chinese medicine composition used in the application.

[0045] Clinical Case 1: Miss Chen, female, 48 years old, first diagnosed on April 10, 2023. Repeated dizziness for more than a year. The patient had no obvious inducement for dizziness more than a year ago, and was diagnosed with “hypertension” at a local hospital. Since then, the patient has been taking antihypertensive drugs to control blood pressure for a long time, but the blood pressure control is not good, and the dizziness has repeatedly recurred. Now seeking treatment with traditional Chinese medicine, so come to the clinic. The blood pressure is 158 / 99 mmHg, dizziness, body discomfort, irritability, bitter taste in the mouth, wake up at midnight, irregular bowel movements, normal urination, pale tongue, white fur, and slow pulse.

[0046] Treatment: The traditional Chinese medicine composition used in the application is heated and extracted to a concentration of 0.5 g / ml, 200 ml each time, and taken 40 minutes after breakfast and dinner every day. After 4 weeks, the blood pressure decreased and stabilized at 130-140 / 80-90 mmHg, and the discomfort such as dizziness improved.

[0047] Clinical Case 2: Miss Zhang, female, 60 years old, first diagnosed on September 18, 2022. Repeated dizziness for more than a year, aggravated for 3 months. The patient had no obvious inducement for paroxysmal dizziness more than a year ago, and the blood pressure was high on multiple measurements, with a maximum blood pressure of 165 / 110 mmHg. The patient took antihypertensive drugs irregularly, but the dizziness still recurred. The dizziness worsened 3 months ago and became persistent, and the antihypertensive drugs could not relieve it, so the patient came to the clinic. The blood pressure is 158 / 99 mmHg, dizziness, insomnia, dry mouth at midnight, bitter taste in the mouth, body discomfort, loose stools about 2 times a day, pale tongue, white fur, and slow pulse.

[0048] Treatment: The traditional Chinese medicine composition used in the application is heated and extracted to a concentration of 0.5 g / ml, 200 ml each time, and taken 40 minutes after breakfast and dinner every day. After 4 weeks, the blood pressure decreased and stabilized at 130-140 / 80-90 mmHg, and the discomfort such as dizziness improved.

[0049] Test Example 2: Acute Toxicity Test 16 healthy C57 mice, 2-4 weeks old, weighing 21-29 g, half male and half female, were selected from Suzhou Xishan Biotechnology Co., Ltd. The mice were adapted to the laboratory environment for 1 day before the experiment, and were free to eat and drink water during the period. The environmental temperature was controlled at 24±2℃, and the relative humidity was 50%±10%.

[0050] Experimental drug, the traditional Chinese medicine composition prepared in Example 1 of the present application, concentration 4g / ml.

[0051] Dosing method: gavage (oral); Dose: 2ml / day, continuous administration for 7 days.

[0052] Body weight measurement method: Before the start of the experiment (day 0), on the 5th day and the 10th day after administration, the body weight of each group of mice was measured. When measuring, the mice were fasted in the afternoon, and an electronic balance was used to weigh each mouse one by one, and the body weight data of each mouse was recorded.

[0053] Blood pressure measurement method: instrument: non-invasive tail cuff method blood pressure meter; measurement condition: mouse in a conscious state; time point: before administration, after administration; number of repeated measurements: 5 effective data were taken for each measurement and averaged.

[0054] Experimental results: all mice survived, the body weight increased compared with before, and the blood pressure showed no obvious change. It shows that the traditional Chinese medicine composition of the present application has low toxicity, and does not have a hypotensive effect on normal mice, and has high safety.

[0055] Test Example 3: Hypotensive effect of the traditional Chinese medicine composition of the present application on primary hypertensive rats 18 male SHR rats of SPF level, weighing 190-200 g, were selected from Suzhou Xishan Biotechnology Co., Ltd. The rats were adapted to the laboratory environment for 3 days before the experiment, and were free to eat and drink water during the period. The environmental temperature was controlled at 24±2℃, and the relative humidity was 50%±10%.

[0056] Grouping method: a total of 3 groups, traditional Chinese medicine composition treatment group, western medicine control group, and blank control group, 6 rats in each group.

[0057] Experimental drug: the traditional Chinese medicine composition prepared in Example 1 of the present application, concentration 2g / ml; Dosing method: gavage (oral); Dose: the traditional Chinese medicine composition treatment group ingested 8.2g of the traditional Chinese medicine composition per day, i.e. 4.1ml; the western medicine control group was given perindopril tert-butylamine tablets 0.5mg / ml, and ingested 4ml per day; the blank control group ingested 4.1ml of normal saline per day.

[0058] Blood pressure measurement method: instrument: non-invasive tail-cuff method blood pressure meter; measurement condition: the mouse is in a conscious state; time point: before administration, 1 week after administration; repeated measurement times: 5 times of effective data for each measurement, and the average value is taken.

[0059] Experimental results: Rat survival: Chinese medicine composition treatment group: 6 all survived; western medicine control group: 5 survived; blank control group: 6 all survived. The survival rate of the Chinese medicine composition treatment group and the blank control group is higher than that of the western medicine control group, see Table 3 for details.

[0060] Table 3 Survival rate of three groups of rats

[0061] Rat treatment effectiveness: 4 rats in the Chinese medicine composition treatment group had decreased systolic pressure, 4 rats had decreased diastolic pressure, and 5 rats had decreased pulse pressure difference after treatment; 5 rats in the western medicine control group had decreased systolic pressure, 4 rats had decreased diastolic pressure, and 5 rats had decreased pulse pressure difference after treatment, see Table 4 for details.

[0062] Table 4 Table of systolic pressure, diastolic pressure and pulse pressure difference decrease after treatment of Chinese medicine composition treatment group and western medicine control group

[0063] The systolic pressure, diastolic pressure and pulse pressure difference of the rats treated effectively in the Chinese medicine composition treatment group and the western medicine control group were compared between groups, and the results showed that the values of blood pressure decrease in the two groups were close, see Table 5 for details: Table 5 Table of systolic pressure, diastolic pressure and pulse pressure difference decrease after treatment of Chinese medicine composition treatment group and western medicine control group

[0064] As shown by the results in Table 5, the values of systolic pressure and diastolic pressure decrease in the SHR rats treated with the Chinese medicine composition of the present application are close to those in the western medicine group, indicating that the Chinese medicine composition of the present application has a good effect of reducing systolic pressure and diastolic pressure.

Claims

1. A traditional Chinese medicine composition for simultaneously reducing systolic and diastolic blood pressure, characterized in that, The traditional Chinese medicine composition is made of raw materials in the following weight proportions: Radix Rehmanniae 15-20 parts, Shanyao 10-20 parts, Fructus Corni 10-20 parts, Radix Astragali 20-30 parts, Radix Puerariae 15-30 parts, Gastrodia 12-15 parts, Uncaria 12-15 parts, Ostrea 30-50 parts, Concha Haliotidis 20-30 parts, Poria 15-30 parts, Alisma 15-30 parts, Cortex Moutan 9-15 parts.

2. The traditional Chinese medicine composition according to claim 1, characterized in that, The traditional Chinese medicine composition is made of raw materials in the following weight proportions: Radix Rehmanniae 15 parts, Shanyao 15 parts, Fructus Corni 12 parts, Radix Astragali 20 parts, Radix Puerariae 20 parts, Gastrodia 12 parts, Uncaria 12 parts, Ostrea 30 parts, Concha Haliotidis 20 parts, Poria 20 parts, Alisma 15 parts, Cortex Moutan 9 parts.

3. The preparation method of the traditional Chinese medicine composition according to claim 1 or 2, characterized in that, The method comprises the following steps: (1) soaking and decocting Ostrea and Concha Haliotidis for 20-30 minutes to obtain a first decoction; (2) soaking and decocting the other raw materials except Ostrea and Concha Haliotidis to obtain a soaking mixture; (3) adding the soaking mixture into the first decoction and decocting twice, each time for 30-60 minutes, filtering, combining the filtrates, and concentrating to obtain the traditional Chinese medicine composition.

4. The preparation method of the traditional Chinese medicine composition according to claim 3, characterized in that, In step (1), the Ostrea and Concha Haliotidis are soaked for 20-60 minutes with water in an amount of 2-5 times. In step (2), the other raw materials are soaked for 20-60 minutes with water in an amount of 1-3 times.

5. The preparation method of the traditional Chinese medicine composition according to claim 3, characterized in that, 6. Use of the traditional Chinese medicine composition of claim 1 or 2 in the preparation of a medicine for treating composite syndrome hypertension. The composite syndrome hypertension is kidney-yin deficiency, liver-yang hyperactivity and qi deficiency type hypertension.

7. Use according to claim 6, characterized in that, The traditional Chinese medicine composition can simultaneously reduce systolic and diastolic blood pressure and improve symptoms of fatigue and soreness of the waist and knees.

8. Use according to claim 6, characterized in that, The medicine comprises an effective amount of the traditional Chinese medicine composition and a pharmaceutically acceptable carrier.

9. Use according to claim 6, characterized in that, The dosage form of the medicine comprises a decoction, a tablet, a capsule, a granule, a pill, an injection, a decocted paste, a suspension, a dispersion, a syrup, a suppository, a gel, an aerosol, a patch or an oral liquid.

10. Use according to claim 9, characterized in that, The traditional Chinese medicine composition is made of raw materials in the following weight proportions: Radix Rehmanniae 15-20 parts, Shanyao 10-20 parts, Fructus Corni 10-20 parts, Radix Astragali 20-30 parts, Radix Puerariae 15-30 parts, Gastrodia 12-15 parts, Uncaria 12-15 parts, Ostrea 30-50 parts, Concha Haliotidis 20-30 parts, Poria 15-30 parts, Alisma 15-30 parts, Cortex Moutan 9-15 parts. The traditional Chinese medicine composition is made of raw materials in the following weight proportions: Radix Rehmanniae 15 parts, Shanyao 15 parts, Fructus Corni 12 parts, Radix Astragali 20 parts, Radix Puerariae 20 parts, Gastrodia 12 parts, Uncaria 12 parts, Ostrea 30 parts, Concha Haliotidis 20 parts, Poria 20 parts, Alisma 15 parts, Cortex Moutan 9 parts. including the following steps: (1) soaking and decocting Ostrea and Concha Haliotidis for 20-30 minutes to obtain a first decoction; (2) soaking and decocting the other raw materials except Ostrea and Concha Haliotidis to obtain a soaking mixture; (3) adding the soaking mixture into the first decoction and decocting twice, each time for 30-60 minutes, filtering, combining the filtrates, and concentrating to obtain the traditional Chinese medicine composition. In step (1), the Ostrea and Concha Haliotidis are soaked for 20-60 minutes with water in an amount of 2-5 times. In step (2), the other raw materials are soaked for 20-60 minutes with water in an amount of 1-3 times.

6. Use of the traditional Chinese medicine composition of claim 1 or 2 in the preparation of a medicine for treating composite syndrome hypertension. The composite syndrome hypertension is kidney-yin deficiency, liver-yang hyperactivity and qi deficiency type hypertension. The traditional Chinese medicine composition can simultaneously reduce systolic and diastolic blood pressure and improve symptoms of fatigue and soreness of the waist and knees. The medicine comprises an effective amount of the traditional Chinese medicine composition and a pharmaceutically acceptable carrier. The dosage form of the medicine comprises a decoction, a tablet, a capsule, a granule, a pill, an injection, a decocted paste, a suspension, a dispersion, a syrup, a suppository, a gel, an aerosol, a patch or an oral liquid.

Images