Essence lotion with repairing and anti-wrinkle functions and preparation method thereof

This serum, formulated with a combination of rare ginsenosides and Panax notoginseng leaf/stem extracts, addresses the issues of unstable ingredients and limited efficacy in existing skincare products. It offers multiple benefits including soothing, repairing, and anti-wrinkle effects, making it suitable for sensitive skin and safe and non-irritating.

CN121512893APending Publication Date: 2026-02-13JIANGXI JIZHIYUE COSMETICS CO LTD
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Patent Information

Application Number
CN202310660033.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2023-06-06
Publication Date
2026-02-13

AI Technical Summary

Technical Problem

Existing skincare products have unstable ingredients, contain chemical components, are not friendly to sensitive skin, and lack products that combine soothing, repairing, and anti-wrinkle effects. They also have poor user experience and unclear safety.

Method used

Using rare ginsenosides and Panax notoginseng leaf/stem extract as the main ingredients, combined with emollients, moisturizers, emulsifiers, etc., a natural and safe essence lotion is prepared, which provides soothing, repairing and anti-wrinkle effects through synergistic effects.

Benefits of technology

It significantly improves skin health, reduces irritation, enhances the skin barrier function, delays aging, is safe with no side effects, and is suitable for sensitive skin.

✦ Generated by Eureka AI based on patent content.

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Patent Text Reader

Abstract

The invention discloses essence lotion with repairing and anti-wrinkle functions. The essence lotion is prepared from the following components in parts by weight: 0.1 to 1.0 part of rare ginsenoside, 0.1 to 1.5 parts of panax notoginseng leaf / stem extract, 3 to 20 parts of emollient, 8 to 20 parts of polyhydric alcohol humectant, 0.2 to 10 parts of saccharide humectant, 0.1 to 5 parts of emulsifier, 0.1 to 0.8 part of thickener, 0.1 to 5 parts of skin conditioner, 0.01 to 0.2 part of chelating agent and the balance of water. The essence lotion provided by the invention has the effect of widely protecting the skin, achieves a synergistic effect by adding the specific rare ginsenoside and the panax notoginseng leaf / stem extract, and is remarkable in effect. Safety inspection, human body efficacy evaluation and consumer use test results prove that after the traditional Chinese medicine composition is used, the obvious soothing, repairing and anti-wrinkle effects on facial skin are achieved, and no side effect or adverse reaction exists.
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Description

TECHNICAL FIELD

[0001] The present application relates to the field of cosmetics, in particular to a serum cream with anti-wrinkle function and a preparation method thereof. BACKGROUND

[0002] With the rapid development of social economy, the pressure faced by people in various positions is also increasing day by day, especially students and overtime workers, who often stay up late to meet performance and pay attention to academic papers, and their irregular work and rest schedules cause endocrine disorders, which is an important reason for skin function damage. Of course, endocrine disorders are only one of the reasons for skin problems, including internal factors such as genetic inheritance, age, negative emotions, and external factors such as increasing environmental pollution, excessive skin care damage to skin keratin, mask suffocation during the epidemic, and external drug stimulation, etc. Internal and external factors cause skin inflammation, and further lead to several common skin problems: sensitivity, acne, wrinkles, dryness and peeling, blackheads, dullness, roughness, and sebaceous granules, etc.

[0003] Most of the skin care products on the market have unstable ingredients and contain certain chemical components, which are not friendly to sensitive skin with damaged skin barrier. Not only can't they achieve the purpose of skin care, but also can increase the burden on the skin.

[0004] Some existing technologies disclose multi-functional serum creams for soothing, repairing and anti-wrinkle, such as patent CN111920713B discloses a skin-whitening and repairing serum, which mainly includes chicory extract, purple sargassum extract and hookweed extract. The effect of the extract is to make the extracts interact with each other to improve the overall repair effect, and to help the skin lock the effective components, so that the nutrients in the skin are not easily lost, thereby better protecting the skin.

[0005] Patent CN110974749B discloses a soothing and repairing composition and a soothing and repairing solid preparation, wherein the soothing and repairing components include 0.5-5% hydroxy asiaticoside, 5-10% hamamelis virginiana extract, 20-40% musclease and 40-65% auxiliary materials. It has soothing and repairing effect, long shelf life and high stability, and is especially suitable for people with allergic skin.

[0006] Patent CN114617812A discloses a cosmetic with repairing, soothing and redness-reducing effects, which includes S-753 1 part, spilanthes acuta extract 5 parts, rosemary extract 0.4 parts, houttuynia cordata extract 0.2 parts, glycyrrhiza extract 0.2 parts, honeysuckle extract 0.2 parts, cnidium monnieri extract 0.2 parts, and sodium hyaluronate, betaine and panthenol. It can significantly reduce red blood vessels, repair skin barrier and improve skin immunity, making the skin more energetic.

[0007] However, although the existing disclosed essence / cosmetic claims multiple effects, the commercially available plant extract has deep color, heavy taste and many impurities. In order to improve the product effect, the addition amount is blindly increased, the product color and odor are heavy, the consumer use feeling is poor, the human body allergy rate is also increased, the components are not clear, the human body effect verification or toxicology test is rarely done, the real use effect of the cosmetic is unknown and needs to be further clarified. In addition, most of the essences on the market are moisturizing and soothing, and few products have soothing, repairing and anti-wrinkle functions. The multiple effects still need to be further innovated. SUMMARY

[0008] The purpose of the present application is to provide an essence with repairing and anti-wrinkle functions and a preparation method thereof.

[0009] The purpose of the present application is achieved by the following technical solutions.

[0010] An essence with repairing and anti-wrinkle functions comprises the following components by weight: 0.1-1.0 parts of rare ginsenoside, 0.1-1.5 parts of notoginseng leaf / stem extract, 3-20 parts of emollient, 8-20 parts of polyhydric alcohol humectant, 0.2-10 parts of sugar humectant, 0.1-5 parts of emulsifier, 0.1-0.8 parts of thickening agent, 0.1-5 parts of skin conditioning agent, 0.01-0.2 parts of chelating agent, and water to make up to 100 parts.

[0011] As a preferred technical solution of the present application, an essence with repairing and anti-wrinkle functions comprises the following components by weight: 0.1-0.5 parts of rare ginsenoside, 0.4-1.5 parts of notoginseng leaf / stem extract, 5-15 parts of emollient, 10-15 parts of polyhydric alcohol humectant, 0.2-2 parts of sugar humectant, 0.1-3 parts of emulsifier, 0.2-0.6 parts of thickening agent, 0.5-5 parts of skin conditioning agent, and 0.02-0.05 parts of chelating agent.

[0012] As a further preferred technical solution of the present application, it comprises the following components by weight: 0.15-0.3 parts of rare ginsenoside, 0.4-1 parts of notoginseng leaf / stem extract, 6-13 parts of emollient, 11-14 parts of polyhydric alcohol humectant, 0.3-1 parts of sugar humectant, 0.1-2.5 parts of emulsifier, 0.2-0.5 parts of thickening agent, 0.5-4.5 parts of skin conditioning agent, and 0.02-0.04 parts of chelating agent.

[0013] As a further preferred technical solution of the present application, the components include the following weight parts: rare ginsenoside 0.2-0.3 parts, Panax notoginseng leaf / stem extract 0.4-1 part, emollient 9-11 parts, polyhydric alcohol humectant 11-12 parts, sugar humectant 0.4-0.6 parts, emulsifier 2-2.5 parts, thickening agent 0.2-0.4 parts, skin conditioning agent 0.5-0.6 parts, chelating agent 0.04-0.06 parts.

[0014] As a preferred technical solution of the present application, the mass ratio of the rare ginsenoside and the Panax notoginseng stem and leaf extract is 1:1-15, and further preferably, the mass ratio of the rare ginsenoside and the Panax notoginseng stem and leaf extract is 1:1.2-5.

[0015] As a preferred technical solution of the present application, the rare ginsenoside is a mixture containing at least 8 rare ginsenosides 20-(R)-Rg3, 20-(S)-Rg3, Rg5, Rk1, 20-(R)-Rh2, 20-(S)-Rh2, Rh3, Rk2.

[0016] The rare ginsenoside of the present application is composed of rare ginsenosides in a specific ratio, mainly including 8 rare ginsenosides 20-(R)-Rg3, 20-(S)-Rg3, Rg5, Rk1, 20-(R)-Rh2, 20-(S)-Rh2, Rh3, Rk2. Compared with the polysaccharide-based ginsenosides Rb1, Rb2, Rb3, Rc, Rd, etc. contained in Panax ginseng, the rare ginsenoside has a more significant effect of promoting the secretion of collagen by skin fibroblasts and has a more significant anti-inflammatory effect. As a preferred technical solution of the present application, the Panax notoginseng leaf / stem extract is specifically PNLS from Jiangxi Kangyi Ginseng Biotechnology Co., Ltd., wherein the total saponin of proto-ginseng diol active ingredient is not less than 90%.

[0017] As a preferred technical solution of the present application, the emollient includes at least one of caprylic / capric triglyceride, squalane, jojoba oil, butyrospermum parkii butter, cetyl stearyl alcohol.

[0018] As a preferred technical solution of the present application, the humectant includes at least one of sorbitol, butylene glycol, 1,2-hexanediol, glycerin, propylene glycol.

[0019] As a preferred technical solution of the present application, the sugar humectant includes at least one of glycerin polyether-26, betaine, trehalose, sodium hyaluronate, beta-glucan chitin polysaccharide derivative.

[0020] As a preferred technical solution of the present application, the emulsifier includes at least one of olive oil emulsifier, alkyl glycoside, polyhydric alcohol ester and ester thereof.

[0021] As a preferred technical solution of the present application, the thickening agent comprises at least one of traganth, carbomer, acrylate / C10-30 alkyl acrylate crosspolymer.

[0022] As a preferred technical solution of the present application, the chelating agent comprises at least one of disodium EDTA and tetrasodium EDTA.

[0023] As a preferred technical solution of the present application, the pH regulator comprises at least one of arginine, sodium hydroxide, potassium hydroxide, and tromethamine.

[0024] As a preferred technical solution of the present application, the essence milk further comprises at least one of skin conditioning agents, preservatives, fragrances, and antioxidants.

[0025] The preparation method of the essence milk with repair and anti-wrinkle functions comprises the following steps:

[0026] (1) Put rare ginsenosides, polyol humectants, sugar humectants, thickening agents, chelating agents, and water into a stirring pot, stir and heat to 80-85℃, continue to stir to completely mix the materials, and obtain a mixed liquid A;

[0027] (2) Mix the emollients and emulsifiers, stir and heat to 80-85℃, completely mix the materials, and obtain a mixed liquid B;

[0028] (3) Put the mixed liquid B into the mixed liquid A, homogenize and stir, and adjust the pH of the material when the temperature drops to 60-65℃;

[0029] (4) Continue to stir, and when the temperature drops to below 40℃, add notoginseng leaf / stem extract and fragrances, stir uniformly, and detect the discharge.

[0030] The rare ginsenosides used in the present application are rare ginsenosides prepared by hydrolysis of polysaccharide-based protopanax diol saponins in Panax plants, which have multiple effects such as anti-tumor, anti-fatigue, nerve protection, disease prevention, and immune enhancement, and have stronger physiological activity than polysaccharide-based protopanax diol saponins. The rare ginsenosides have also been confirmed to have significant soothing and repairing effects such as repairing damaged skin barrier, delaying fibroblast aging, antioxidant, anti-glycation, and anti-inflammatory. The rare ginsenosides used in the present application are composed of 8 or more rare ginsenosides such as 20-(R)-Rg3, 20-(S)-Rg3, Rg5, Rk1, 20-(R)-Rh2, 20-(S)-Rh2, Rh3, and Rk2, which are particularly obvious for improving and repairing skin and anti-wrinkle effect.

[0031] The Panax notoginseng leaf / stem extract used in the present application is from the leaves and stems of Panax notoginseng, which is traditionally used for external bleeding, contusion and swelling, and carbuncle and sore, and modern pharmacological studies show that it has the effects of analgesia, anti-inflammation and anti-aging.

[0032] As a preferred technical solution of the present application, the preparation method of the Panax notoginseng leaf / stem extract is as follows: the Panax notoginseng stems and leaves are cut into sections, and are boiled with water for at least twice, the decoction is filtered, the filtrate is combined and is eluted through two D101 or AB8 macroporous adsorption resin columns in series, 8-10 times the column volume of water is used for elution until the eluate is colorless, and then 3-5 times the column volume of 40%-95% ethanol is used for elution, the eluate is further eluted through two D280 or D900 macroporous adsorption resins in series, the eluate is collected, is concentrated into a thin extract, glycerol or butanediol is added, and the mixture is stirred uniformly to obtain the Panax notoginseng stem and leaf extract. Alternatively, commercially available Panax notoginseng stem and leaf extract can be used as the raw material, dissolved in 3-5 times the volume of deionized water, eluted through a D900 macroporous adsorption resin, the eluate is collected, is concentrated into a thin extract, glycerol or butanediol is added, and the mixture is stirred uniformly to obtain the Panax notoginseng stem and leaf extract. The Panax notoginseng leaf / stem extract and the rare ginsenoside synergize with each other to improve the skin care effect.

[0033] Compared with the prior art, the present application has the following innovative points:

[0034] The present application mainly provides an essence cream integrating soothing, repairing and anti-wrinkle effects, and the main components of the present application are selected from completely natural green rare ginsenosides and Panax notoginseng leaf / stem extract. In particular, the rare ginsenosides are a mixture of 8 or more rare ginsenosides, such as 20-(R)-Rg3, 20-(S)-Rg3, Rg5, Rk1, 20-(R)-Rh2, 20-(S)-Rh2, Rh3 and Rk2, which have the effect of protecting the skin. The Panax notoginseng leaf / stem extract is further added to synergistically improve the effect, and is compounded with emollients, humectants and other raw materials, so that the essence cream has a remarkable effect. The raw materials added in the present application are all green components, which have no irritation to the skin, and have been subjected to perfect human efficacy verification and toxicology tests. The final product has obvious effect and is safe and has no side effects, and there is no pressure for sensitive skin. DETAILED DESCRIPTION

[0035] The technical solutions in the embodiments of the present application will be described clearly and completely below. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of the present application.

[0036] Examples 1-4

[0037] An essence milk with repair anti-wrinkle function, the specific raw material composition and formula content are shown in Table 1, and the specific preparation method is as follows:

[0038] (1) Put rare ginsenosides, polyol humectants, sugar humectants, thickening agents, chelating agents, skin conditioning agents, and water into a stirring pot, stir and heat to 80-85℃, continue to stir to make the materials completely mixed and uniform, to obtain mixed solution A;

[0039] (2) Mix the emollients and emulsifiers, stir and heat to 80-85℃, and make the materials completely mixed and uniform, to obtain mixed solution B;

[0040] (3) Add mixed solution B to mixed solution A, homogenize and stir, and adjust the material body pH when the temperature drops to 60-65℃;

[0041] (4) Continue to stir, and when the temperature drops to below 40℃, add notoginseng leaf / stem extract and fragrance, stir uniformly, and detect the discharge.

[0042] Table 1 Specific formula components of Examples 1-4

[0043]

[0044] Among them, the specific sources of each raw material in Table 1 are as follows:

[0045] The rare ginsenosides are specifically RGI from Jiangxi Kangyishen Biological Technology Co., Ltd., which is composed of 8 or more rare ginsenosides such as 20-(R)-Rg3, 20-(S)-Rg3, Rg5, Rk1, 20-(R)-Rh2, 20-(S)-Rh2, Rh3, and Rk2;

[0046] The notoginseng leaf / stem extract is specifically PNLS from Jiangxi Kangyishen Biological Technology Co., Ltd., wherein the total saponins of the active ingredient proto-ginseng diol are not less than 90%;

[0047] The emulsifier is specifically from SEPPIC S.A.;

[0048] The thickening agent is xanthan gum;

[0049] Butylene glycol is specifically from DAICEL CORPORATION;

[0050] The fragrance is (daily use) perfume, specifically from Qiaowatong Daily Use Perfume & Flavor (Shanghai) Co., Ltd.;

[0051] The others not mentioned are all conventional components commonly used in the cosmetic field.

[0052] In addition, in order to investigate the influence of each component on the performance of the product, the following comparative examples are provided, and the specific formula of each comparative example is shown in Table 2.

[0053] Comparative Example 1:

[0054] This comparative example is basically the same as Example 1, except that no rare ginsenoside is added in this comparative example.

[0055] Comparative Example 2:

[0056] This comparative example is basically the same as Example 1, except that no notoginseng leaf / stem extract is added in this comparative example.

[0057] Comparative Example 3:

[0058] This comparative example is basically the same as Example 1, except that no rare ginsenoside and notoginseng leaf / stem extract are added in this comparative example.

[0059] Comparative Example 4:

[0060] This comparative example is basically the same as Example 1, except that the rare ginsenoside is a mixture of 0.2 parts by weight of polysaccharide-based ginsenoside (Rb1, Rb2, Rb3, Rc, etc.), which is a precursor of the rare ginsenoside saponin prepared in this patent.

[0061] Comparative Example 5:

[0062] This comparative example is basically the same as Example 1, except that the notoginseng leaf / stem extract is a commercially available notoginseng leaf / stem extract (UV method for measuring total saponin content > 80%).

[0063] Table 2 Specific formulation components of Comparative Examples 1-5

[0064]

[0065]

[0066] Effect verification:

[0067] 1. Subjective evaluation of use effect

[0068] Test population: people with different degrees of skin discomfort

[0069] Gender number: male / female, 40 people

[0070] Age distribution: between 18 and 60 years old

[0071] 40 people respectively use the samples of examples 1-4 and comparative examples 1-5, and after 1h, 5h, comprehensive subjective evaluation is carried out, and any one of soothing repair or anti-wrinkle has effect or general effect, that is, it is determined to have effect or general effect, and subjective evaluation is checked according to good effect, general effect and no effect, and the results are shown in table 3.

[0072] Table 3 subjective use effect evaluation

[0073]

[0074]

[0075] As shown in the above table, the test personnel generally have subjective feeling of good effect for the product of the examples; and the product use experience in the comparative examples is generally not as good as the examples, and the sample color of comparative example 5 is deep, 10 people feedback that the experience feeling is poor, and 5 people feedback that there is slight stinging sensation.

[0076] 2, the effect verification of the essence cream prepared from each example and comparative example is as follows:

[0077] Test population

[0078] Gender number: male / female, at least 30 people

[0079] Age distribution: between 18 and 60 years old

[0080] Skin type of the testee: the testee with sensitive skin, the total score of the lactic acid stinging test > 3 can be selected as the testee with sensitive skin.

[0081] Since 5 people in comparative example 5 feedback that there is slight stinging sensation, the efficacy evaluation uses the samples of examples 1-4 and comparative examples 1-4.

[0082] Test method: the testee cleans the face with a dry paper towel, sits still for 30 min in a laboratory with temperature 21℃±1℃ and RH 50%±10%, and tests the skin stratum corneum moisture content, trans-epidermal water loss TEWL value, skin hemoglobin Erythema value and wrinkle index SEw value of the face of the testee before using the sample, after using for 14 days and after using for 28 days.

[0083] The skin elasticity tester MPA580 (Corneometer probe, Tewameter probe, Mexameter probe) and the skin surface texture analysis system Visioscan VC20plus are respectively used to test the same area of the cheek of the testee, and the arithmetic mean value is taken, and the results are shown in tables 4-7:

[0084] Table 4 skin stratum corneum moisture content

[0085] As shown in the above table, the test personnel generally have subjective feeling of good effect for the product of the examples; and the product use experience in the comparative examples is generally not as good as the examples, and the sample color of comparative example 5 is deep, 10 people feedback that the experience feeling is poor, and 5 people feedback that there is slight stinging sensation.

[0086]

[0087] Table 5 Trans-epidermal water loss (TEWL) values

[0088] Sample Base value (D0) After 14 days of use of the sample (D14) After 28 days of use of the sample (D28) Example 1 22.13±4.76 20.23±5.71 17.42±6.06 Example 2 22.21±5.12 20.46±5.58 18.25±5.79 Example 3 22.08±5.38 20.14±5.15 18.53±6.01 Example 4 22.15±4.89 20.08±5.07 18.46±5.87 Comparative Example 1 22.23±5.31 23.17±4.33 22.09±6.43 Comparative Example 2 22.20±5.27 23.64±5.21 22.71±5.49 Comparative Example 3 22.17±5.43 23.71±4.17 22.43±5.69 Comparative Example 4 22.11±5.52 21.59±5.23 19.39±6.57

[0089] Table 6 Skin erythema values

[0090] Sample Base value (D0) After 14 days of use of the sample (D14) After 28 days of use of the sample (D28) Example 1 308.12±59.63 278.81±60.32 262.90±60.11 Example 2 307.49±60.12 284.17±60.03 262.98±61.10 Example 3 308.02±60.63 279.32±60.41 263.81±60.06 Example 4 307.85±60.24 281.39±60.17 272.45±60.03 Comparative Example 1 309.23±60.08 293.14±62.97 280.75±66.21 Comparative Example 2 311.55±60.35 291.47±63.58 280.13±65.49 Comparative Example 3 313.71±59.94 290.89±62.53 295.38±66.07 Comparative Example 4 310.81±60.05 291.77±63.34 280.27±65.19

[0091] Table 7 Wrinkle index (Sew) values

[0092]

[0093]

[0094] Lactic acid stinging test:

[0095] The subject's face was cleaned with a dry paper towel, 10% lactic acid 50 μΐ was dropped on a single layer filter paper with a diameter of 0.8 cm, which was placed on the subject's nasolabial groove, and the subject was asked about the stinging sensation and the skin reaction was observed at 30 s, 2.5 min, 5 min, respectively, and the stinging sensation was scored from 0-3 according to no, mild, moderate and severe stinging, and the total score of lactic acid stinging test ≥3 was selected as sensitive skin subjects. The results of lactic acid stinging score are shown in Table 8:

[0096] Table 8 Lactic acid stinging score

[0097] Sample Base value (D0) After 14 days of use of the sample (D14) After 28 days of use of the sample (D28) Example 1 4.05±0.95 3.75±0.70 1.62±0.60 Example 2 4.10±0.90 3.83±0.80 1.83±0.55 Example 3 4.08±0.85 3.68±0.71 1.98±0.61 Example 4 4.02±1.01 3.77±0.81 1.79±0.45 Comparative Example 1 4.04±0.73 3.92±0.93 1.99±0.73 Comparative Example 2 4.12±0.82 3.89±0.76 1.87±0.72 Comparative Example 3 4.07±0.79 4.01±0.88 2.01±0.69 Comparative Example 4 4.03±0.94 3.73±0.86 1.83±1.03

[0098] Product safety evaluation

[0099] Human skin patch test: qualified patch tester materials with an area of not more than 50 mm 2 , and a depth of 1 mm were selected. The test substance was placed in the patch tester chamber, and the amount was about 0.020 g-0.025 g (solid or semi-solid) or 0.020 ml-0.025 ml (liquid). The patch tester with the test substance was applied to the back of the subject with a low sensitization tape for 24 h, and the skin reaction was observed and recorded at 0.5 h (after the indentation disappeared), 24 h, 48 h, respectively, according to the skin reaction grading standard of the skin closed patch test in the "Cosmetic Safety Technology Standard" (2015 edition).

[0100] The human skin patch test results according to the above method and standard show that 33 subjects respectively through the patch test of the emulsion of examples 1-4, 0 cases of skin adverse reactions occurred at 0.5h, 24h, 48h after the removal of the test patch, indicating that the emulsion is safe for use.

[0101] Multiple skin irritation test: Before the test, the animals were adapted to the environment of the experimental animal room for 3 days. About 24 hours before the test, the fur on both sides of the back of the experimental animals was cut, without damaging the epidermis. The left and right areas of 3*3 cm were shaved. 0.5 ml of the test substance was directly applied to one side of the skin, with an application area of 2.5*2.5 cm. The application was performed once a day for 14 consecutive days. From the second day, the fur was cut before each application, and the residual test substance was removed with water. The results were observed after one hour. The skin reaction score was evaluated according to P491 Table 1 of the "Cosmetic Safety Technology Standard" (2015 edition). The control area and the test area were treated in the same way. Results evaluation: the average score per animal per day was calculated according to the following formula, and the skin irritation intensity was determined according to P492 Table 2.

[0102] Average score per animal per day = (total score of erythema and edema / number of test animals) / 14

[0103] The results of the multiple skin irritation test according to the above method and standard show that the emulsion of examples 1-4 has no skin irritation to rabbits, indicating that the emulsion with repair and anti-wrinkle function is mild (non-irritating).

[0104] Sensitive skin evaluation test: 33 subjects were randomly divided into groups. According to the product use requirements and use site, the subjects were guided to use the product, and written product use precautions and product use instructions were provided. Before use (day 0), 14 days after use and 28 days after use, the subjects were followed up by telephone, and the skin reaction grading results were recorded according to the skin reaction grading standard of the "Cosmetic Safety Technology Standard" (2015 edition).

[0105] The safety evaluation results of the human use test according to the above method and standard show that 33 subjects through the use test of the emulsion of examples 1-4, 0 cases of skin adverse reactions occurred after 14 days and 28 days of use, indicating that the emulsion with repair and anti-wrinkle function is suitable for sensitive skin.

[0106] The foregoing description of the embodiments has been presented for the purpose of illustration and description. It is not intended to be exhaustive or to limit the application to the precise form disclosed. Modifications and variations are possible in light of the above teachings or can be acquired from practice of the application. As well, the description is presented in the context of the preferred embodiments as a number of alternatives. It is not intended to limit the application to the precise form described.

Claims

1. A serum with repairing and anti-wrinkle functions, characterized in that, It comprises the following components in parts by weight: 0.1-1.0 parts rare ginsenosides, 0.1-1.5 parts Panax notoginseng leaf / stem extract, 3-20 parts emollient, 8-20 parts polyol moisturizer, 0.2-10 parts sugar moisturizer, 0.1-5 parts emulsifier, 0.1-0.8 parts thickener, 0.1-5 parts skin conditioning agent, 0.01-0.2 parts chelating agent, and water as the balance.

2. The essence lotion with repairing and anti-wrinkle functions according to claim 1, characterized in that, It includes the following components in parts by weight: 0.1-0.5 parts rare ginsenosides, 0.4-1.5 parts Panax notoginseng leaf / stem extract, 5-15 parts emollient, 10-15 parts polyol moisturizer, 0.2-2 parts sugar moisturizer, 0.1-3 parts emulsifier, 0.2-0.6 parts thickener, 0.1-0.5 parts skin conditioning agent, and 0.02-0.05 parts chelating agent.

3. The serum with repairing and anti-wrinkle function according to claim 1 or 2, characterized in that, The emollients include at least one of caprylic / capric triglycerides, squalane, jojoba oil, shea butter, and cetearyl alcohol.

4. The serum with repairing and anti-wrinkle function according to claim 1 or 2, characterized in that, The polyol moisturizers include at least one of sorbitol, butylene glycol, 1,2-hexanediol, glycerin, and propylene glycol.

5. The serum with repairing and anti-wrinkle function according to claim 1 or 2, characterized in that, The saccharide humectant includes at least one of glyceryl polyether-26, betaine, trehalose, sodium hyaluronate, and β-glucan chitosan polysaccharide derivatives.

6. The serum with repairing and anti-wrinkle function according to claim 1 or 2, characterized in that, The emulsifier includes at least one of olive oil emulsifier, alkyl glycoside, polyol ester and its esters; The thickener includes at least one of xanthan gum, carbomer, and acrylate / C10-30 alkanol acrylate crosspolymers.

7. The serum with repairing and anti-wrinkle function according to claim 1 or 2, characterized in that, The chelating agent includes at least one of disodium EDTA and tetrasodium EDTA. The serum also includes at least one of skin conditioning agents, preservatives, fragrances, and antioxidants; The pH adjuster includes at least one of arginine, sodium hydroxide, potassium hydroxide, and tromethamine.

8. The serum with repairing and anti-wrinkle function according to claim 1 or 2, characterized in that, The active ingredient in the Panax notoginseng leaf / stem extract, protopanaxadiol total saponins, is not less than 90%.

9. The serum with repairing and anti-wrinkle function according to claim 1 or 2, characterized in that, The rare ginsenosides are a mixture containing at least eight rare ginsenosides: 20-(R)-Rg3, 20-(S)-Rg3, Rg5, Rk1, 20-(R)-Rh2, 20-(S)-Rh2, Rh3, and Rk2.

10. The method for preparing an essence lotion with repairing and anti-wrinkle functions according to claim 1 or 2, characterized in that, Includes the following steps: (1) Add rare ginsenosides, polyol moisturizers, sugar moisturizers, thickeners, chelating agents and water to the main pot, stir and heat to 80-85℃, continue stirring to make the materials completely and evenly mixed to obtain mixture A; (2) Mix the emollient and emulsifier, stir and heat to 80-85°C to make the materials completely and evenly mixed to obtain mixture B; (3) Add mixture B to mixture A, homogenize and stir, and adjust the pH of the material when the temperature drops to 60-65℃; (4) Continue stirring until the temperature drops below 40°C. Add Panax notoginseng leaf / stem extract and fragrance, stir evenly, and check the discharge.

Citation Information

Patent Citations

  • Soothing and repairing compositions, soothing and repairing solid dosage forms and their preparation methods

    CN110974749B