Anti-aging composition as well as preparation method and application thereof
By combining hydrolyzed proanthocyanidins, Terminalia chebula fruit extract, and resveratrol, the problem of insufficient efficacy and safety of existing anti-aging cosmetics is solved, achieving a highly effective and safe anti-aging effect, significantly promoting collagen production, reducing wrinkles and sagging, and improving skin hydration and elasticity.
Patent Information
- Application Number
- CN202511652271.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-11-12
- Publication Date
- 2026-01-23
AI Technical Summary
Existing anti-aging cosmetics suffer from problems such as insignificant anti-aging effects, high prices, insufficient safety, and lack of innovation, making it difficult to meet consumer needs.
This product uses a combination of hydrolyzed proanthocyanidins, Terminalia chebula fruit extract, and resveratrol. Through synergistic effects, it increases skin hydration, improves the skin barrier, enhances skin elasticity, firms the skin, and delays aging. It also uses natural plant extracts to ensure safety.
It achieves highly effective and safe anti-aging effects, significantly promotes collagen production, reduces wrinkles and sagging, and improves skin hydration and elasticity. The product is also stable, easy to manufacture, and has a good user experience.
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Abstract
Description
TECHNICAL FIELD
[0001] The present application belongs to the field of cosmetics, and particularly relates to an anti-aging composition and a preparation method and application thereof. BACKGROUND
[0002] With the growth of age, the skin, like other organs of the human body, will naturally age, leading to weakened or lost functions, and various pathologies. Skin aging is a natural process and can be divided into intrinsic aging and extrinsic aging. Intrinsic aging, also known as natural aging, is affected by genetics and the body's own cell aging, and is manifested in the following aspects: the regenerative ability of skin cells decreases, the cell renewal rate decreases, and the decomposition of collagen accelerates; the water content of the skin decreases, and the barrier function decreases; the number of melanocytes decreases, leading to pigmented patches and spots; the number of sebaceous glands and sweat glands decreases, leading to a decrease in sebum film content; subcutaneous fat decreases, causing skin to become loose and elastic to decrease. Therefore, over time, the skin will become thin, dry, desquamate, loose, develop wrinkles, pigmented spots, and various benign neoplasms.
[0003] In view of the problem of skin aging, the market has launched a variety of cosmetics for delaying skin aging. Anti-aging cosmetics occupy an important position in the market, but there are still some deficiencies, mainly in the following aspects: (1) the anti-aging effect is not obvious, the effect is slow, and some products cannot even achieve the expected effect. This may be related to the concentration of ingredients, formula design, or individual differences. For example, some products claim to contain high-activity ingredients, but the actual concentration is low, making it difficult to play a significant role. (2) The price is relatively high, and the prices of high-end anti-aging products are generally high, especially some international brands or products containing patented ingredients. This makes it difficult for some consumers to use them for a long time, limiting the market coverage. (3) There are safety problems, and some anti-aging ingredients (such as high-concentration retinoic acid and some peptides) can cause allergies or irritation, especially for people with sensitive skin. In addition, some products have deficiencies in ingredient safety testing, which poses potential risks. (4) Technology dependence and lack of innovation, domestic brands still rely on foreign patented ingredients in anti-aging technology, and have weak independent research and development capabilities. Some products are highly homogenized in technology, lack breakthrough innovation, and are difficult to meet the needs of consumers for high-efficiency anti-aging.
[0004] In summary, anti-aging cosmetics need to be further improved in terms of effect, price, safety, and innovation to better meet the needs of consumers. SUMMARY
[0005] In view of the above technical problems to be solved, the present application aims to provide a novel composition with high-efficiency anti-aging effect, which not only has high-efficiency anti-aging effect, but also is safe and non-irritating, has good use feeling, simple production process, and stable product.
[0006] To achieve the above object, the present application provides the following technical solutions. In the first aspect, the present application provides an anti-aging composition comprising the following components by weight: 0.001-0.2 parts of hydrolyzed procyanidins, 0.001-0.2 parts of Terminalia ferdinandiana fruit extract, and 0.001-5 parts of resveratrol.
[0007] Preferably, the anti-aging composition comprises the following components by weight: 0.001-0.002 parts of hydrolyzed procyanidins, 0.001-0.002 parts of Terminalia ferdinandiana fruit extract, and 0.005-0.01 parts of resveratrol.
[0008] In the second aspect, the present application provides an anti-aging essence comprising the anti-aging composition of the present application and adjuvants.
[0009] Preferably, the adjuvants comprise one or more of moisturizers, preservatives, thickening agents, pigments, fragrances, chelating agents, and pH regulators.
[0010] More preferably, the moisturizers are one or more of glycerol, propylene glycol, butylene glycol, 1,3-butanediol, and polyethylene glycol.
[0011] More preferably, the preservatives are one or more of sodium benzoate, potassium sorbate, p-hydroxyacetophenone, 1,2-hexanediol, 1,2-pentanediol, phenoxyethanol, ethylhexylglycerin, caprylyl glycol, and glyceryl caprylate.
[0012] More preferably, the thickening agents are one or more of cyclodextrin, acrylates / C10-30 alkyl acrylate crosspolymer, polyacrylate crosspolymer-6, acryloyldimethyltaurine ammonium / VP copolymer, carbomer, xanthan gum, sodium polyacrylate, cellulose derivatives, polyethylene glycol, and natural thickening agents.
[0013] In the third aspect, the present application further provides a preparation method of the anti-aging composition, comprising the following steps: weighing hydrolyzed procyanidins, Terminalia ferdinandiana fruit extract, and resveratrol, and mixing them uniformly.
[0014] In the fourth aspect, the present application further provides application of the anti-aging composition in skin care products.
[0015] Preferably, in the application, the anti-aging composition increases skin water content, improves skin barrier, increases skin elasticity, tightens skin, and delays skin aging.
[0016] Preferably, the skin care products are products for improving skin health, including but not limited to skin care water, skin care milk, skin care cream, cream, essence, and the like.
[0017] The active ingredients of the present application are all natural plant extracts, which are safer and more easily absorbed by the skin than traditional chemical synthetic products, thereby making the product more effective.
[0018] Hydrolyzed procyanidins are derived from grape seeds and have extremely strong antioxidant capacity. Anthocyanins, also known as cyanidins, exist in the form of glycosides in the natural state, which are called anthocyanins, and there are very few free anthocyanins. Anthocyanins are currently internationally recognized as the most effective natural antioxidants for scavenging free radicals in the human body. Anthocyanins perform well in antioxidant and free radical resistance, and they can eliminate excess free radicals, restore collagen activity, make the skin smooth and elastic, and achieve the effect of delaying aging. Applying anthocyanins to skin care products can have multiple effects, such as anti-aging, brightening, moisturizing, soothing, anti-ultraviolet, anti-radiation, etc. Since ultraviolet rays in sunlight can stimulate the skin to produce a large number of oxidative free radicals, anthocyanins are also known as natural skin "sunshades" that can effectively resist the damage of ultraviolet rays to the skin and reduce post-sun inflammation. Reaction to repair damaged skin.
[0019] Terminalia ferdinandiana (T. ferdinandiana) Terminalia Ferdinandiana ) fruit extract is rich in vitamin C, rich in polyphenols such as gallic acid and ellagic acid. Vitamin C plays an important role in maintaining young and healthy skin. This powerful active molecule protects the skin by neutralizing free radicals, effectively neutralizing free radicals, reducing their damage to skin cells such as collagen and elastin, thereby delaying skin aging. By reducing oxidative damage, it helps protect skin structure and maintain skin flexibility and elasticity. By neutralizing free radical-induced skin damage, it protects the skin from oxidative stress; it also promotes collagen biosynthesis in young and aged skin. In addition, as an anti-inflammatory ingredient, it can prevent post-inflammatory pigmentation and has a skin lightening effect by blocking a key step in melanin production. In addition, Terminalia ferdinandiana fruit extract promotes the synthesis of type I procollagen, which is a precursor molecule of collagen synthesized by fibroblasts. Damaged stimulation signals in aged skin can lead to reduced collagen synthesis, which in turn weakens the skin structure. At a concentration of 0.4%, Terminalia ferdinandiana fruit extract can increase the synthesis of type I procollagen. Hyaluronic acid helps maintain skin hydration and viscoelasticity. With age, hyaluronic acid synthesis often decreases. At low concentrations, Terminalia ferdinandiana fruit extract can increase the synthesis of hyaluronic acid, thereby maintaining skin hydration and viscoelasticity. Terminalia ferdinandiana fruit extract also induces upregulation of expression of multiple ligand protein glycosaminoglycan-1, which helps stimulate epidermal turnover, a physiological characteristic that is affected by age. Protect and strengthen the dermis, thereby improving the overall appearance of the skin.
[0020] Resveratrol is a non-flavonoid polyphenol compound, naturally occurring in plants such as grapes, giant knotweed, blueberries, etc. Its mechanism of action goes far beyond simple antioxidant, involving deep regulation at the cellular level. The phenolic hydroxyl structure of resveratrol can directly scavenge and neutralize the excess free radicals (ROS) generated in the skin by ultraviolet light, pollution, etc. Prevent these "destructive molecules" from attacking healthy skin cells, collagen and elastin. Resveratrol can activate the body's own antioxidant defense network, such as through the Nrf2 pathway, up-regulate the activity of key antioxidant enzymes such as superoxide dismutase (SOD), glutathione peroxidase, etc., thereby enhancing the overall antioxidant capacity of the skin. Resveratrol is a well-known activator of Sirtuin 1 (Sirt1) protein. Sirtuins are known as "longevity proteins", which are responsible for regulating cell health, repair and survival. Sirt1 can sense the energy state of the cell (NAD+ level), and is activated when energy is limited, which is closely related to delaying aging. Sirt1 can help repair damaged DNA, maintain the stability of the genome, and reduce the probability of cells "aging" or cancer due to damage. By regulating related pathways, it delays the entry of cells into the aging state, thereby maintaining the number and vitality of functional cells in the skin. Sirt1 can inhibit the main inflammatory signaling pathway, thereby reducing chronic inflammation associated with aging from the root. The tightness and fullness of the skin depends on the collagen and elastin network in the dermis. Resveratrol can inhibit the activity and expression of matrix metalloproteinases (MMPs). These enzymes (such as collagenase MMP-1) are "scissors" that break down collagen and elastin. Their activity will increase dramatically when exposed to ultraviolet radiation. Resveratrol can effectively "hold down the scissors", thereby slowing down the loss of collagen. Through its antioxidant and Sirt1-activating effects, it creates a healthier environment for fibroblasts, indirectly supporting collagen synthesis. Resveratrol can inhibit NF-κB, a key inflammatory master switch. When the NF-κB pathway is inhibited, the production of a series of pro-inflammatory factors (such as TNF-α, IL-1β, IL-6) will be reduced, thereby reducing the inflammatory response of the skin and improving redness, sensitivity and aging problems caused by inflammation.
[0021] The present application combines hydrolyzed procyanidins, Terminalia ferdinandiana fruit extract, and resveratrol, and finds that these components exhibit good synergistic effects in anti-aging.
[0022] Compared with the prior art, the anti-aging composition has the beneficial effects that: first, the three compositions synergistically and efficiently resist aging through different paths; second, the anti-aging composition system is combined with polyhydric alcohol, thickening agent and other basic raw materials to prepare an anti-aging essence, which can relieve inflammatory reaction, remove wrinkles, repair damaged skin and restore the natural and healthy state of the skin. The anti-oxidation essence does not need high-speed homogenization and emulsification, has low energy consumption, simple production process and stable product. DETAILED DESCRIPTION
[0023] In order to facilitate the understanding of the present application, the present application will be described more fully below with reference to specific embodiments. The present application can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the disclosure of the present application more thorough and comprehensive.
[0024] In the description of the present application, unless otherwise explicitly defined, the words of heating, cleaning, weighing, freezing and the like should be understood in a broad sense, and those skilled in the art can reasonably determine the specific meaning of the above words in the present application in combination with the specific content of the technical solution.
[0025] In the description of the present application, the description of the terms "some embodiments", "examples" and the like means that the specific methods, materials described in combination with the embodiments or examples are included in at least one embodiment or example of the present application. In the present specification, the illustrative description of the above terms does not necessarily refer to the same embodiment or example. Moreover, the described specific methods, materials can be combined in any one or more embodiments or examples in a suitable manner.
[0026] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which the present application belongs. The terms used in the specification of the present application herein are only for the purpose of describing the specific embodiments and are not intended to limit the present application.
[0027] In the following examples and comparative examples, the experimental methods used are conventional methods unless otherwise specified, and the materials, reagents and the like used are commercially available unless otherwise specified.
[0028] EDTA disodium was purchased from Norlion Chemicals (Ningbo) Co., Ltd.
[0029] Glycerol was purchased from Palmedia (M) Sdn. Bhd.
[0030] Butanediol was purchased from OQ Chemicals.
[0031] Acrylates / C10-30 Alkyl Acrylate Crosspolymer was purchased from Lubrizol Specialty Chemicals Manufacturing (Shanghai) Co., Ltd.
[0032] Hexanediol was purchased from DuPont Tate & Lyle Bio Products.
[0033] Resveratrol was purchased from Shanghai Jia Kai Biological Technology Co., Ltd.
[0034] Terminalia ferdinandiana Fruit Extract was purchased from Southern Cross Botanicals.
[0035] Hydrolyzed Proanthocyanidins were purchased from Guangzhou Hongzhong Biological Technology Co., Ltd.
[0036] Ascorbic Acid (Vitamin C) was purchased from Shandong Tianli Pharmaceutical Co., Ltd.
[0037] The composition provided by the present application has the composition shown in Table 1.
[0038] Table 1: Anti-aging composition formula (by weight)
[0039] The preparation method of the above-mentioned composition comprises the following steps: weighing each raw material component according to the amount, and mixing uniformly.
[0040] Fibroblast firming and anti-wrinkle test Test purpose: Firming and anti-wrinkle efficacy test The anti-aging efficacy of cosmetic raw materials is evaluated by stimulating human skin fibroblasts HSF to establish an aging cell model with hydrogen peroxide (H2O2), and by measuring the effect of the sample on the expression of collagen and matrix metalloproteinase in the cells.
[0041] Test method: Refer to "SOP-XB-22 Anti-aging efficacy test of hydrogen peroxide-induced human fibroblast aging test operation instruction" The experimental results are shown in Table 2.
[0042] Table 2: Collagen type I (COL-1) expression results
[0043] Table 3: Collagen type III (COL-3) expression results
[0044] Table 4: Matrix metalloproteinase 1 (MMP-1) expression results
[0045] Collagen type I (COL-1) mainly exists in the skin, bones, muscles and other connective tissues, and plays a key role in maintaining the integrity and elasticity of the tissue structure. When COL-1 is specifically degraded, the normal structure of collagen fibers and elastic fibers in the body is destroyed, which can cause skin aging phenomena such as wrinkles.
[0046] Collagen type III (COL-3) is an important protein for maintaining skin elasticity, and when COL-3 is specifically degraded, the skin will show a series of aging performances such as sagging, wrinkles, dark spots, etc.
[0047] Matrix metalloproteinase (MMP) is a highly conserved class of proteases in nature evolution, and MMP-1 is the main enzyme for degrading collagen type III. When MMP-1 is overexpressed, it specifically degrades the extracellular matrix components and destroys the normal structure of collagen fibers and elastic fibers.
[0048] As can be seen from the results of Tables 2-4, the composition of the present embodiment 1-2 has a significantly higher promoting effect on collagen types I and III than the compositions or single components of the comparative examples 1-7, and a significantly higher inhibition rate on MMP-1 than the compositions or single components of the comparative examples 1-7, which proves that the components in the composition of the present application can produce a synergistic effect, thus better promoting the generation of collagen, thereby being beneficial to protecting the integrity of the skin structure, tightening the skin and reducing skin wrinkles and sagging.
[0049] Antioxidant performance test: A 0.25 mmol / L DPPH-ethanol solution was prepared, 100 uL of which was taken by a pipette and placed in a 96-well plate. Then, 100 uL of the dispersion solution prepared in the present embodiment 1-2 and the comparative examples 1-7 was taken and mixed with the DPPH-ethanol solution in the 96-well plate, respectively. After standing for 30 min, the samples were placed at 517 nm to measure the absorbance value. Three parallel samples were set for each experiment. The DPPH free radical scavenging rate was calculated according to the following formula: scavenging rate (%) = ([A0-A] / A0) x 100. Wherein, A0 is the absorbance value of the blank control group, and A is the absorbance value of the experimental group.
[0050] Table 5: Results of DPPH free radical scavenging test
[0051] As can be seen from the results of Table 5, the DPPH free radical scavenging rate of the composition of the present embodiment 1-2 is significantly higher than that of the compositions or single components of the comparative examples 1-7, which proves that the components in the composition of the present application can produce a synergistic effect, thus having a better antioxidant effect.
[0052] In some embodiments, the anti-aging composition of the present application can be applied to various types of cosmetics, and common dosage forms include skin care water, skin care milk, skin care cream, etc. The following will be further described by taking the common dosage form of anti-aging skin care essence as an example.
[0053] Referring to Table 6, the preparation method of the anti-aging essence of application examples 1-2 and application comparative examples 1-7 includes the following steps (skip the corresponding step if the ingredient is not added): 1. First, mix C phase and prepare for use.
[0054] 2. Add water to the emulsifying kettle, slowly sprinkle in the thickening agent and soak for 10-15 minutes, then add the remaining raw materials of A phase, heat to 80-85°C, and stir at 30-60 r / min until there are no particles and start to cool.
[0055] 3. Cool to 45°C, add B phase and stir (20-40 r / min) until dissolved and uniform, then add C phase and D phase raw materials in turn and stir uniformly.
[0056] 4. Filter the product with 200 mesh filter cloth, and the anti-aging essence can be obtained after standing.
[0057] Table 6: Formulation of the anti-aging essence of application examples 1-2 and application comparative examples 1-7 (by weight percentage)
[0058] Product safety evaluation (human skin patch test) 1. Test product: anti-aging essence prepared by application examples 1-2 and application comparative examples 1-7.
[0059] Number of subjects: 90 people, male to female ratio 1:1.
[0060] Age: 18-30 years old.
[0061] Health status: The subjects have healthy skin, no history of skin disease and allergy, and meet the voluntary selection criteria of the subjects.
[0062] Grouping: 9 groups, 10 people in each group.
[0063] 2. Patch method: use qualified patch testers, and in a closed patch test method, about 0.020g-0.025g of the test material after shaking is dropped into the patch tester, and the special adhesive tape is applied to the back of the subject. After 24 hours, remove the test material, and observe the skin reaction at 0.5, 6, 12, 24 and 48 hours after removal, respectively, and record the results according to the skin reaction grading standard in the "Cosmetic Hygiene Standard".
[0064] 3. Experimental results: Human skin patch test results showed that each group of subjects applied the anti-aging serum prepared by examples 1-2 and application comparative examples 1-7, and observed the skin reaction at 0.5, 6, 12, 24, and 48 hours. No adverse skin reactions were observed, indicating that the anti-aging serum is safe to use.
[0065] Product anti-skin aging effect evaluation Select 100 female subjects aged 25-50, randomly divided into 10 groups (10 people per group), each group corresponds to use one of the application examples or application comparative example serum samples, the subjects have fine lines, dry skin or uneven skin problems, and a blank control group is set. The subjects applied the samples after cleansing in the morning and evening every day, and continuously used them for 4 weeks (the blank control group did not use any product), and the following indicators were detected before use and 4 weeks after use: (1) Fine line depth: The average depth of periorbital fine lines was detected using a Visioscan VC98 skin texture instrument.
[0066] (2) Skin elasticity: The R2 value (elastic recovery rate) was measured using a Cutometer MPA580 skin elasticity instrument.
[0067] (3) Skin moisture content: The stratum corneum water content was measured using a Corneometer CM825.
[0068] The results are shown in Table 7.
[0069] Table 7: Anti-skin aging effect
[0070] The results show that, compared with application comparative examples 1-7, the periorbital fine line depth is significantly reduced, the skin elasticity is significantly improved, and the skin moisture content is significantly improved after using the anti-aging serum of the present application. It can be seen that the skin anti-aging composition of the present application has good effects in improving skin moisture content, improving skin barrier, increasing skin elasticity, and tightening skin.
[0071] The formula system of the anti-aging serum of the present application uses mild plant extract ingredients, which can relieve inflammatory reactions, repair damaged skin, and restore the natural and healthy state of the skin. The use process is light and easy to absorb, and the skin feels not sticky after use, with good use feeling; the preparation process of the anti-aging serum does not require high-speed homogenization emulsification, has low energy consumption, simple production process, meets the national relevant regulations in terms of hygiene and safety, the product is stable, and has good application value.
[0072] The above merely describes preferred embodiments of the present application, and is not intended to limit the present application in any form. Any simple modification, equivalent change and modification made to the above embodiments without departing from the technical solutions of the present application, and in accordance with the technical essence of the present application, are still within the scope of the technical solutions of the present application.
Claims
1. An anti-aging composition characterized in that, The anti-aging composition comprises the following components by weight parts: hydrolyzed procyanidins 0.001-0.2 parts, Terminalia ferdinandiana fruit extract 0.001-0.2 parts, resveratrol 0.001-5 parts.
2. Anti-aging composition according to claim 1, characterized in that, The anti-aging composition comprises the following components by weight parts: hydrolyzed procyanidins 0.001-0.002 parts, Terminalia ferdinandiana fruit extract 0.001-0.002 parts, resveratrol 0.005-0.01 parts.
3. An anti-aging skin care product, characterized by, The anti-aging composition comprises the following components by weight parts:
4. The anti-aging skincare product according to claim 3, wherein, The adjuvant comprises one or more of a humectant, a preservative, a thickening agent, a pigment, a fragrance, a chelating agent, and a pH regulator.
5. The anti-aging skin care product according to claim 4, wherein The humectant is one or more of glycerin, propylene glycol, butylene glycol, 1,3-butylene glycol, and polyethylene glycol.
6. The anti-aging skincare product of claim 4, wherein, The preservative is one or more of sodium benzoate, potassium sorbate, p-hydroxyacetophenone, 1,2-hexanediol, 1,2-pentanediol, phenoxyethanol, ethylhexylglycerin, caprylyl glycol, and glyceryl caprylate.
7. The anti-aging skin care product according to claim 4, wherein The thickening agent is one or more of a cyclodextrin, an acrylates / C10-30 alkyl acrylate crosspolymer, a polyacrylate crosspolymer-6, an ammonium acryloyldimethyltaurate / VP copolymer, a carbomer, a xanthan gum, a sodium polyacrylate, a cellulose derivative, a polyethylene glycol, and a natural thickening agent.
8. The method of preparing an anti-aging composition according to claim 1 or 2, wherein the method comprises the steps of: The method comprises the following steps: hydrolyzed procyanidins, Terminalia ferdinandiana fruit extract, and resveratrol are weighed and mixed uniformly.
9. Use of the anti-aging composition of claim 1 or 2 in a skin care product.
10. Use according to claim 9, characterized in that, The anti-aging composition improves skin moisture content, skin barrier, skin elasticity, skin firmness, and skin aging.