Traditional Chinese medicine composition for treating constipation as well as preparation method and application thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating constipation as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The composition comprises the following components in parts by weight: 45 to 85 parts of Chinese pulsatilla root, 45 to 85 parts of oldenlandia diffusa, 45 to 85 parts of sculellaria barbata, 80 to 140 parts of Chinese actinidia root, 45 to 85 parts of trogopterus dung, 80 to 140 parts of coix seed, 80 to 140 parts of poria cocos, 80 to 140 parts of rhizoma pinellinae praeparata, 45 to 85 parts of pericarpium citri reticulatae, 60 to 100 parts of bighead atractylodes rhizome, 45 to 85 parts of endothelium corneum gigeriae galli, 60 to 100 parts of white hyacinth bean, 60 to 100 parts of dried ginger and 45 to 85 parts of liquorice. The traditional Chinese medicine composition has a good treatment effect on constipation caused by gastrointestinal tumors, is mild in medicine property, and is specially developed for patients with constipation caused by tumors.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating constipation and a preparation method and application thereof. BACKGROUND

[0002] Gastrointestinal tumors refer to tumor diseases occurring in the digestive tract such as stomach, small intestine, large intestine, etc. According to biological behavior, they can be divided into benign tumors and malignant tumors. The benign tumors grow slowly, have clear boundaries, and usually do not metastasize, but may cause compression symptoms or risk of malignancy due to volume increase. The malignant tumors have invasiveness and metastasis, and are the main health threat of gastrointestinal tumors. Common types include gastric cancer, colorectal cancer, gastrointestinal stromal tumor, esophageal cancer, etc.

[0003] Cancer toxicity is severe, and constipation is a common symptom in patients of this kind. Mechanical obstruction caused by tumors, postoperative intestinal adhesion, intestinal nerve damage after radiotherapy and chemotherapy, long-term use of opioid sedatives, etc. are the main causes of constipation. In traditional Chinese medicine, constipation in tumor patients is classified as "intestinal knot" or "constipation". The pathogenesis is complex, and is mainly caused by deficiency of vital energy and excess of evil, and disorder of viscera and bowels.

[0004] At present, there are many Chinese patent medicines for constipation on the market, but most of them are for functional constipation, and there are almost no drugs for constipation caused by severe cancer. Most of the drugs for functional constipation are not suitable for cancer patients. SUMMARY

[0005] In view of the above deficiencies in the prior art, the present application provides a traditional Chinese medicine composition for treating constipation and a preparation method and application thereof. The traditional Chinese medicine composition has good therapeutic effect on constipation caused by gastrointestinal tumors, and its medicinal properties are mild, and is specially developed for constipation patients caused by tumors.

[0006] To achieve the above object, the technical scheme adopted by the present application to solve its technical problems is:

[0007] A traditional Chinese medicine composition for treating constipation comprises the following components by weight: 45-85 parts of white head onion, 45-85 parts of white flower snake tongue grass, 45-85 parts of half branch lotus, 80-140 parts of fig root, 45-85 parts of five spirit fat, 80-140 parts of yiyi, 80-140 parts of poria cocos, 80-140 parts of fahai, 45-85 parts of dried tangerine or orange peel, 60-100 parts of white atractylodes, 45-85 parts of chicken gizzard, 60-100 parts of white horse bean, 60-100 parts of dried ginger, and 45-85 parts of licorice.

[0008] Further, the components include the following weight parts: white peony 60-70 parts, Chinese hygrophila 60-70 parts, half branch orchid 60-70 parts, tree fern root 100-120 parts, five spices 60-70 parts, coix seed 100-120 parts, hoelen 100-120 parts, pinellia ternate 60-70 parts, dried tangerine or orange peel 60-70 parts, white atractylodes 75-90 parts, chicken gizzard 60-70 parts, white horse bean 75-90 parts, dried ginger 75-90 parts, and licorice 60-70 parts.

[0009] Further, the components include the following weight parts: white peony 66.7 parts, Chinese hygrophila 66.7 parts, half branch orchid 66.7 parts, tree fern root 111.1 parts, five spices 66.7 parts, coix seed 111.1 parts, hoelen 111.1 parts, pinellia ternate 66.7 parts, dried tangerine or orange peel 66.7 parts, white atractylodes 88.9 parts, chicken gizzard 66.7 parts, white horse bean 88.9 parts, dried ginger 88.9 parts, and licorice 66.7 parts.

[0010] Further, the components include the following weight parts: white peony 60 parts, Chinese hygrophila 70 parts, half branch orchid 70 parts, tree fern root 120 parts, five spices 60 parts, coix seed 120 parts, hoelen 120 parts, pinellia ternate 70 parts, dried tangerine or orange peel 60 parts, white atractylodes 75 parts, chicken gizzard 70 parts, white horse bean 75 parts, dried ginger 75 parts, and licorice 60 parts.

[0011] Further, the components include the following weight parts: white peony 70 parts, Chinese hygrophila 60 parts, half branch orchid 60 parts, tree fern root 100 parts, five spices 70 parts, coix seed 100 parts, hoelen 100 parts, pinellia ternate 60 parts, dried tangerine or orange peel 70 parts, white atractylodes 90 parts, chicken gizzard 60 parts, white horse bean 90 parts, dried ginger 90 parts, and licorice 70 parts.

[0012] Further, the five spices are vinegar five spices, the white atractylodes is bran-fried white atractylodes, the white horse bean is fried white horse bean, and the licorice is fried licorice.

[0013] The preparation method of the above-mentioned traditional Chinese medicine composition for treating constipation includes the following steps: crushing and mixing each raw material to obtain; or mixing or separately extracting each raw material to obtain an extract; or further refining and purifying the effective component of the extract to obtain; or adding the extract / effective component to pharmaceutically acceptable excipients to obtain.

[0014] Further, the prepared dosage form is one of a pill, granules, a capsule, a powder, a mixture, a tablet, a decoction, or an oral liquid.

[0015] Further, the specific preparation method is as follows: the above fourteen ingredients are decocted with water, the decoction is combined, concentrated to a relative density of 1.15-1.2, and then left to stand, centrifuged, and the supernatant is removed, pharmaceutically acceptable excipients are added, mixed, heated to boiling, and then prepared.

[0016] The application of the traditional Chinese medicine composition in preparing a medicine for treating constipation caused by gastrointestinal tumors.

[0017] The beneficial effects of the present application are:

[0018] Bai Touweng has the effects of clearing heat and resolving toxicity, cooling blood and stopping diarrhea, is specially aimed at the heat-toxin accumulation syndrome, sets the core direction of clearing heat and expelling evil for the whole prescription, and is the monarch drug in the prescription;

[0019] Baihua Shechegacai and Banzhang Lian have the effects of clearing heat and resolving toxicity, clearing heat and resolving stasis, both of which are cold and cool, can significantly enhance the core effect of Bai Touweng in clearing heat and resolving toxicity, and enhance the effect of expelling evil; at the same time, Baihua Shechegacai and Banzhang Lian can also clear heat and resolve stasis, and have therapeutic effects on the stasis and lumps caused by heat and toxin; both of them are the ministerial drugs;

[0020] Teng Li Gen has the effects of clearing heat and resolving toxicity, dredging collaterals and stopping pain, and can assist the monarch and ministerial drugs in removing deep heat and toxin; Wu Ling Zhi activates blood and resolves stasis, and has therapeutic effects on the stasis caused by long-term heat and toxin; Yiyiren, Fuling, Baizhu and Bai Doucheng all can invigorate the spleen and replenish qi, and have therapeutic effects on the spleen deficiency and dampness caused by heat and toxin, and can balance the evil and the body resistance at the same time, so as to avoid further damage to the spleen and stomach by heat and toxin or cold and cool; Jinejin has the effect of digesting food and resolving accumulation, and can assist the spleen-invigorating drugs to improve food accumulation caused by spleen deficiency; Ganjiang has the effect of warming the middle and dispelling cold, and directly restricts the cold nature of Bai Touweng, Baihua Shechegacai and other content drugs, so as to avoid damaging the spleen and stomach yang qi and preventing diarrhea and abdominal pain caused by excessive heat clearing; Banxia and Chenpi have the effects of drying dampness and resolving phlegm, regulating qi and stomach, which can resolve the damp phlegm caused by spleen deficiency on one hand, and let the spleen-invigorating drugs play a better role on the other hand, balance the problem of qi stagnation caused by cold and cool drugs, and all of the above are the auxiliary drugs;

[0021] Gancao has a mild nature, can moderate the nature of other drugs, and is the assistant drug.

[0022] In the present application, the whitehead, white snake grass and half branch orchid play the role of expelling evil, concentrate on removing heat and toxin, and are used for treating symptoms; Baizhu and Fuling are spleen-invigorating drugs, can repair the damage of the spleen and stomach caused by heat and toxin, are used for treating the root cause, provide the basis for expelling evil, and play the role of supporting the body resistance; Ganjiang restricts cold and cool, and Gancao adjusts the whole situation, so as to ensure that expelling evil does not harm the body resistance, and supporting the body resistance does not love evil, and finally realize the effect of clearing heat without cold, invigorating the spleen without stagnation, and have good therapeutic effects on constipation caused by deep cancer toxin. DETAILED DESCRIPTION

[0023] In order to make the purpose, technical scheme and advantages of the present application clearer and more apparent, the present application will be further described in detail below in combination with embodiments. It should be understood that the specific embodiments described herein are only used to explain the present application, and are not used to limit the present application, that is, the described embodiments are only a part of the embodiments of the present application, but not all the embodiments.

[0024] Therefore, the following detailed description of the embodiments of the application provided is not intended to limit the scope of the application claimed, but merely represents selected embodiments thereof. Based upon the embodiments of the application, all other embodiments falling within the scope of the application claimed are intended to be included as well, without having to be inventive.

[0025] It should be noted that the terms "first", "second", and so forth, are used merely to distinguish one entity or action from another, and do not necessarily require or imply any such actual relationship or order between such entities or actions. Also, the terms "comprises", "comprising", or any other variations thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but can include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element preceded by "comprises a" does not, without more constraints, foreclose the existence of additional identical elements in the process, method, article, or apparatus that comprises the element.

[0026] The features and characteristics of the application will be further described in connection with the embodiments below.

[0027] Example 1

[0028] A traditional Chinese medicine composition for treating constipation is prepared from the following components in parts by weight: Radix Pulsatillae 45 parts, Oldenlandia 85 parts, Herba Bartramiae 85 parts, Actinidia 140 parts, Myrobalan 45 parts, Radix Rehmanniae 140 parts, Poria 140 parts, Rhizoma Pinelliae 140 parts, Pericarpium Citri Reticulatae 45 parts, Rhizoma Atractylodis Macrocephalae 60 parts, Gigeriae Cacumen 85 parts, Phaseoli 100 parts, Rhizoma Zingiberis Recens 60 parts, and Radix Glycyrrhizae 45 parts.

[0029] The traditional Chinese medicine composition is prepared by decocting the above fourteen ingredients with water for three times, each time for 1 hour, adding 10 times water for the first time and 8 times water for the second and third times, combining the decocted liquid, concentrating to a relative density of 1.15-1.2, standing, centrifuging, taking the supernatant, adding sucralose and potassium sorbate, mixing, and heating to boiling to obtain the product.

[0030] Example 2

[0031] A traditional Chinese medicine composition for treating constipation is prepared from the following components in parts by weight: Radix Pulsatillae 85 parts, Oldenlandia 45 parts, Herba Bartramiae 45 parts, Actinidia 80 parts, Myrobalan 85 parts, Radix Rehmanniae 80 parts, Poria 80 parts, Rhizoma Pinelliae 80 parts, Pericarpium Citri Reticulatae 85 parts, Rhizoma Atractylodis Macrocephalae 100 parts, Gigeriae Cacumen 45 parts, Phaseoli 60 parts, Rhizoma Zingiberis Recens 100 parts, and Radix Glycyrrhizae 85 parts.

[0032] The specific preparation method of the traditional Chinese medicine composition is as follows: the above fourteen ingredients are decocted with water for three times, each time for 1 hour, 10 times water is added in the first time, 8 times water is added in the second and third times, the decoction is combined after decocting, concentrated to relative density 1.15-1.2, left to stand, centrifuged, the supernatant is taken, sucralose and potassium sorbate are added, mixed, heated to boiling to prepare.

[0033] Example 3

[0034] A traditional Chinese medicine composition for treating constipation is prepared from the following components in parts by weight: 60 parts of white head onion, 70 parts of white flower snake grass, 70 parts of half branch lotus, 120 parts of tree grape root, 60 parts of five spiritual fat, 120 parts of coix seed, 120 parts of hoelen, 70 parts of law pinellia, 60 parts of dried tangerine or orange peel, 75 parts of white atractylodes, 70 parts of gizzard, 75 parts of white horse bean, 75 parts of dried ginger and 60 parts of licorice.

[0035] The specific preparation method of the traditional Chinese medicine composition is as follows: the above fourteen ingredients are decocted with water for three times, each time for 1 hour, 10 times water is added in the first time, 8 times water is added in the second and third times, the decoction is combined after decocting, concentrated to relative density 1.15-1.2, left to stand, centrifuged, the supernatant is taken, sucralose and potassium sorbate are added, mixed, heated to boiling to prepare.

[0036] Example 4

[0037] A traditional Chinese medicine composition for treating constipation is prepared from the following components in parts by weight: 70 parts of white head onion, 60 parts of white flower snake grass, 60 parts of half branch lotus, 100 parts of tree grape root, 70 parts of five spiritual fat, 100 parts of coix seed, 100 parts of hoelen, 60 parts of law pinellia, 70 parts of dried tangerine or orange peel, 90 parts of white atractylodes, 60 parts of gizzard, 90 parts of white horse bean, 90 parts of dried ginger and 70 parts of licorice.

[0038] The specific preparation method of the traditional Chinese medicine composition is as follows: the above fourteen ingredients are decocted with water for three times, each time for 1 hour, 10 times water is added in the first time, 8 times water is added in the second and third times, the decoction is combined after decocting, concentrated to relative density 1.15-1.2, left to stand, centrifuged, the supernatant is taken, sucralose and potassium sorbate are added, mixed, heated to boiling to prepare.

[0039] Example 5

[0040] A traditional Chinese medicine composition for treating constipation is prepared from the following components by weight: 66.7 parts of white peony root, 66.7 parts of white flower snake tongue grass, 66.7 parts of half branch orchid, 111.1 parts of fig root, 66.7 parts of five spirit incense, 111.1 parts of coix seed, 111.1 parts of hoelen, 66.7 parts of law pinellia, 66.7 parts of dried tangerine or orange peel, 88.9 parts of white atractylodes, 66.7 parts of chicken gizzard, 88.9 parts of white horse bean, 88.9 parts of dried ginger, and 66.7 parts of licorice.

[0041] The specific preparation method of the traditional Chinese medicine composition is as follows: the above fourteen ingredients are decocted with water for three times, each time for 1 hour, 10 times water is added in the first time, 8 times water is added in the second and third times, the decoction is combined after decocting, concentrated to relative density 1.15-1.2, left to stand, centrifuged, the supernatant is taken, sucralose and potassium sorbate are added, mixed evenly, heated to boiling to prepare.

[0042] Comparative Example 1

[0043] A traditional Chinese medicine composition for treating constipation is prepared from the following components by weight: 66.7 parts of white peony root, 66.7 parts of white flower snake tongue grass, 66.7 parts of half branch orchid, 111.1 parts of fig root, 66.7 parts of five spirit incense, 111.1 parts of coix seed, 111.1 parts of hoelen, 66.7 parts of law pinellia, 66.7 parts of dried tangerine or orange peel, 88.9 parts of white atractylodes, 66.7 parts of chicken gizzard, 88.9 parts of white horse bean, 88.9 parts of dried ginger, and 66.7 parts of licorice.

[0044] The specific preparation method of the traditional Chinese medicine composition is as follows: the above fourteen ingredients are decocted with water for three times, each time for 1 hour, 10 times water is added in the first time, 8 times water is added in the second and third times, the decoction is combined after decocting, concentrated to relative density 1.15-1.2, left to stand, centrifuged, the supernatant is taken, sucralose and potassium sorbate are added, mixed evenly, heated to boiling to prepare.

[0045] Comparative Example 2

[0046] A traditional Chinese medicine composition for treating constipation is prepared from the following components by weight: 66.7 parts of white peony root, 66.7 parts of white flower snake tongue grass, 66.7 parts of half branch orchid, 111.1 parts of fig root, 66.7 parts of five spirit incense, 111.1 parts of coix seed, 111.1 parts of hoelen, 66.7 parts of law pinellia, 66.7 parts of dried tangerine or orange peel, 88.9 parts of white atractylodes, 66.7 parts of chicken gizzard, 88.9 parts of white horse bean, 88.9 parts of dried ginger, and 66.7 parts of licorice.

[0047] The specific preparation method of the traditional Chinese medicine composition is as follows: the above fourteen ingredients are decocted with water for three times, each time for 1 hour, 10 times water is added in the first time, 8 times water is added in the second and third times, the decoction is combined after decocting, concentrated to relative density 1.15-1.2, left to stand, centrifuged, the supernatant is taken, sucralose and potassium sorbate are added, mixed evenly, heated to boiling to prepare.

[0048] Test example

[0049] I. General information

[0050] Randomly selected to hospital and diagnosed as gastrointestinal tumor with constipation patients, 33 cases of male, 27 cases of female, age range 45-65 years old, average age 58.2 years old;

[0051] II. Constipation diagnostic criteria

[0052] Constipation core symptoms:

[0053] Decreased defecation frequency (defecation <3 times per week);

[0054] Abnormal stool shape (hard spherical, nut-shaped);

[0055] Straining to defecate, incomplete defecation, anal rectal obstruction during defecation, or need manual assistance to defecate;

[0056] Defecation urgency but unable to defecate;

[0057] Tumor associated symptoms:

[0058] Abdominal pain, abdominal mass (tumor compression intestinal obstruction, may be accompanied by paroxysmal colic);

[0059] Blood in stool (black stool, fresh blood stool)

[0060] Weight loss (6 months weight loss ≥5%), loss of appetite;

[0061] Anemia (tumor chronic blood loss or consume hemoglobin).

[0062] III. Administration method

[0063] The patients were randomly divided into 3 groups, 20 people in each group, and the patients were given the drugs in Example 5, Comparative Examples 1-2, 30 ml per day, 1.1 g of crude drug per ml, 3 times a day, for 30 consecutive days, and the changes in patient symptoms were observed and recorded. The specific results are shown in Table 1.

[0064] IV. Efficacy criteria

[0065] Constipation symptom score: score from 6 dimensions of defecation frequency, stool shape, degree of straining to defecate, etc. (0-3 points for each dimension, total score 0-18 points), combined with imaging auxiliary examination, the efficacy is classified as follows:

[0066] Marked effect: the score after treatment is reduced by ≥70% compared with that before treatment, and imaging review shows that the tumor is significantly reduced;

[0067] Effective: the score after treatment is reduced by 30-69%, and imaging review shows that the tumor is reduced to some extent;

[0068] Invalid: after treatment, the integral is reduced by less than 30%, or the symptoms are aggravated, and the imaging review shows that the tumor is not obviously reduced, or even increased;

[0069] Efficiency (%) = (number of people with obvious effect + number of people with effect) / total number of people * 100%

[0070] V. Therapeutic results

[0071] Group Effective number of persons (person) Effective number of persons (person) Ineffective number of persons (person) Effective rate (%) Example 5 13 6 1 95％ Comparative Example 1 1 7 12 40％ Comparative Example 2 3 8 9 55％

[0072] As can be seen from the data in the above table, the drug in Example 5 has good therapeutic effect on constipation of patients with gastrointestinal tumors. The proportions of the components in Comparative Examples 1 and 2 are adjusted, and it can be seen from the treatment results that the treatment effect of the adjusted components is worse than that of the components in Example 5, and the efficiency is obviously reduced. It is speculated that after adjusting the components, the complementary relationship between the medicinal materials in the components is weakened or disappears, thereby affecting the final treatment effect.

Claims

1. A traditional Chinese medicine composition for treating constipation, characterized in that, The components include the following weight parts: Pulsatillae Radix 45-85 parts, Oldenlandiae Herba 45-85 parts, Huperzia serrata 45-85 parts, Smilax riparia 80-140 parts, Arisaema cum Baeckeafructus 45-85 parts, Coicis Semen 80-140 parts, Poria cocos 80-140 parts, Pinelliae Praeparatae 80-140 parts, Citri Reticulatae Pericarpium 45-85 parts, Atractylodis Macrocephalae 60-100 parts, Gigeriae Cacii 45-85 parts, Lablab Album 60-100 parts, Zingiberis Rhizoma 60-100 parts and Glycyrrhizae Radix 45-85 parts.

2. The traditional Chinese medicine composition for treating constipation according to claim 1, wherein, The components include the following weight parts: Pulsatillae Radix 60-70 parts, Oldenlandiae Herba 60-70 parts, Huperzia serrata 60-70 parts, Smilax riparia 100-120 parts, Arisaema cum Baeckeafructus 60-70 parts, Coicis Semen 100-120 parts, Poria cocos 100-120 parts, Pinelliae Praeparatae 60-70 parts, Citri Reticulatae Pericarpium 60-70 parts, Atractylodis Macrocephalae 75-90 parts, Gigeriae Cacii 60-70 parts, Lablab Album 75-90 parts, Zingiberis Rhizoma 75-90 parts and Glycyrrhizae Radix 60-70 parts.

3. The traditional Chinese medicine composition for treating constipation according to claim 1, wherein, The components include the following weight parts: Pulsatillae Radix 66.7 parts, Oldenlandiae Herba 66.7 parts, Huperzia serrata 66.7 parts, Smilax riparia 111.1 parts, Arisaema cum Baeckeafructus 66.7 parts, Coicis Semen 111.1 parts, Poria cocos 111.1 parts, Pinelliae Praeparatae 66.7 parts, Citri Reticulatae Pericarpium 66.7 parts, Atractylodis Macrocephalae 88.9 parts, Gigeriae Cacii 66.7 parts, Lablab Album 88.9 parts, Zingiberis Rhizoma 88.9 parts and Glycyrrhizae Radix 66.7 parts.

4. The traditional Chinese medicine composition for treating constipation according to claim 1, wherein, The components include the following weight parts: Pulsatillae Radix 60 parts, Oldenlandiae Herba 70 parts, Huperzia serrata 70 parts, Smilax riparia 120 parts, Arisaema cum Baeckeafructus 60 parts, Coicis Semen 120 parts, Poria cocos 120 parts, Pinelliae Praeparatae 70 parts, Citri Reticulatae Pericarpium 60 parts, Atractylodis Macrocephalae 75 parts, Gigeriae Cacii 70 parts, Lablab Album 75 parts, Zingiberis Rhizoma 75 parts and Glycyrrhizae Radix 60 parts.

5. The traditional Chinese medicine composition for treating constipation according to claim 1, wherein the composition is administered in an amount of 0.5 to 2.0 g per day. The components include the following weight parts: Pulsatillae Radix 60 parts, Oldenlandiae Herba 70 parts, Huperzia serrata 70 parts, Smilax riparia 120 parts, Arisaema cum Baeckeafructus 60 parts, Coicis Semen 120 parts, Poria cocos 120 parts, Pinelliae Praeparatae 70 parts, Citri Reticulatae Pericarpium 60 parts, Atractylodis Macrocephalae 75 parts, Gigeriae Cacii 70 parts, Lablab Album 75 parts, Zingiberis Rhizoma 75 parts and Glycyrrhizae Radix 60 parts.

6. The traditional Chinese medicine composition for treating constipation according to any one of claims 1-5, wherein, The Arisaema cum Baeckeafructus is vinegar Arisaema cum Baeckeafructus, the Atractylodis Macrocephalae is bran-fried Atractylodis Macrocephalae, the Lablab Album is fried Lablab Album, and the Glycyrrhizae Radix is fried Glycyrrhizae Radix.

7. The method of preparing the traditional Chinese medicine composition for treating constipation according to any one of claims 1-6, characterized in that, The method includes the following steps: The raw medicinal materials are ground and mixed, or the extracts obtained by mixing or separately extracting the raw medicinal materials are prepared, or the effective components obtained by further refining and purifying the extracts are prepared, or the extracts / effective components are added into pharmaceutically acceptable excipients.

8. The method of preparing the traditional Chinese medicine composition for treating constipation according to any one of claims 1-6, characterized in that, The prepared dosage form is one of a pill, a granule, a capsule, a powder, a mixture, a tablet, a decoction or an oral liquid.

9. The method of preparing the traditional Chinese medicine composition for treating constipation according to any one of claims 1-6, characterized in that, The specific preparation method is as follows: the above fourteen kinds of medicinal materials are decocted with water, the decoction is combined, concentrated to a relative density of 1.15-1.2, and then left to stand, centrifuged, and the supernatant is taken, pharmaceutically acceptable excipients are added, mixed, heated to boiling, and then prepared.

10. The use of the traditional Chinese medicine composition of any one of claims 1-6 in the preparation of a medicament for treating constipation caused by gastrointestinal tumors.