KD01 adenovirus glioma therapeutic device for inhibiting CDCA8

Abstract

The invention relates to the technical field of medical instruments, in particular to a therapeutic apparatus for inhibiting CDCA8 KD01 adenovirus glioma, a drug supply assembly is arranged in a therapeutic apparatus main body, the drug supply assembly comprises a bottom plate, a drug cylinder, a drug supply pump and a tube collecting assembly, the drug cylinder, a drug inlet tube, the drug supply pump and the tube collecting assembly are all fixed to the upper end of the bottom plate, and the drug inlet tube, the drug supply pump and the tube collecting assembly are fixed to the bottom plate. The bottom plate is fixed in the therapeutic apparatus body, a liquid level meter is arranged on one side of the medicine cylinder, the medicine inlet end of the medicine supply pump is communicated with the medicine cylinder through a first guide pipe, the medicine outlet end of the medicine supply pump is provided with a medicine outlet pipe, the upper end of the medicine outlet pipe is provided with a pressure relief box, and a pressure control structure composed of the pressure relief box, a pressure relief block and a lifting assembly is matched with real-time feedback of a pressure detector. And the dynamic regulation of the administration pressure is realized. When the pressure is too high, automatic capacity expansion and pressure relief are achieved, when the pressure is too low, active capacity shrinkage and pressure stabilization are achieved, the problem of pressure fluctuation of traditional equipment is thoroughly solved, brain tissue damage caused by high pressure or insufficient liquid medicine delivery caused by low pressure is avoided, and treatment safety and effectiveness in the intracranial fragile environment are guaranteed.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical devices, in particular to a KD01 adenovirus glioma treatment device for inhibiting CDCA8. BACKGROUND

[0002] Glioma is a high incidence intracranial malignant tumor with strong invasiveness and is limited by the blood-brain barrier. The traditional treatment has limited effect. CDCA8 is abnormally highly expressed in glioma cells and is a key target for regulating tumor proliferation. CDCA8 targeted therapy based on KD01 adenovirus becomes a hot spot in clinical research because it can specifically induce tumor cell apoptosis. The treatment needs to deliver adenovirus to the local intracranial tumor lesion through a medical minimally invasive drug delivery probe to ensure the effectiveness of the treatment.

[0003] However, the existing adenovirus drug delivery equipment has the following technical defects: first, there is no precise pressure control structure. The intracranial environment is special and fragile. Abnormal drug delivery pressure may occur due to manual operation and equipment power fluctuations. High pressure may damage brain tissue or blood vessels. Low pressure may result in uneven adenovirus delivery rate and insufficient concentration in the lesion area, directly affecting the treatment effect. Second, the drug delivery catheter has no special storage design. The drug delivery catheter is messy and easy to entangle and knot during carrying. Temporary installation affects efficiency, and the exposed catheter is easy to be contaminated, increasing the risk of intracranial infection. SUMMARY

[0004] (I) Technical problems solved In view of the shortcomings of the prior art, the present application provides a KD01 adenovirus glioma treatment device for inhibiting CDCA8.

[0005] (II) Technical solutions To achieve the above-mentioned purpose, the present application provides the following technical solutions: a KD01 adenovirus glioma treatment device for inhibiting CDCA8, comprising a treatment device main body, a control module is arranged at the upper end of the treatment device main body, a display screen and a control panel are arranged on one side of the treatment device main body, a through hole is arranged at the front end of the treatment device main body, and a drug delivery catheter penetrates through the through hole; a drug supply assembly is arranged in the treatment device main body, the drug supply assembly comprises a bottom plate, a drug cartridge, a drug supply pump and a pipe collecting assembly, the drug cartridge, the drug inlet pipe, the drug supply pump and the pipe collecting assembly are fixed to the upper end of the bottom plate, the bottom plate is fixed to the inside of the treatment device main body, a liquid level meter is arranged on one side of the drug cartridge, the liquid level meter is connected to the display screen through an electrical signal, the drug inlet end of the drug supply pump is communicated with the drug cartridge through a first catheter, the drug outlet end of the drug supply pump is provided with a drug outlet pipe, the upper end of the drug outlet pipe is provided with a pressure relief tank, the inside of the pressure relief tank is provided with a pressure relief groove communicated with the drug outlet pipe, a pressure relief block is slidably arranged in the pressure relief groove, a lifting assembly is fixedly arranged at the upper end of the pressure relief tank, the output end of the lifting assembly is provided with a driving rod penetrating through the pressure relief tank and connected to the pressure relief block, and the drug supply pump is connected to the control module and the control panel through an electrical signal respectively; The collecting pipe assembly comprises a cylindrical pipe and a support frame fixed at the upper end of the bottom plate, the front end of the cylindrical pipe penetrates through the support frame and is rotationally connected with the support frame through a bearing, a first adapter pipe is fixedly arranged on one side of the support frame, the first adapter pipe is connected with the front end of the cylindrical pipe through a rotary joint, a second adapter pipe is fixedly arranged on the middle part of the cylindrical pipe, and two circular baffles are fixedly arranged on the second adapter pipe in a symmetrical manner, one outer side of the circular baffles is provided with a rotating shaft penetrating through the main body of the treatment device, one end of the drug delivery catheter located inside the main body of the treatment device is connected with the second adapter pipe, the drug delivery catheter is coiled between the two circular baffles, the medicine outlet end of the medicine outlet pipe is connected with the first adapter pipe through a second catheter, a pressure detector is arranged on the first adapter pipe, and the pressure detector is connected with the lifting assembly through an electrical signal.

[0006] In order to facilitate the replacement of the drug delivery tank, the upper end of the treatment device main body is provided with an opening, the opening is provided with a first cover, the first cover is inserted into the opening and is threadedly connected with the opening, the first cover is opened, and the drug delivery tank is conveniently taken out of the treatment device main body.

[0007] Further, the front end of the treatment device main body is fixedly provided with an annular frame and a second cover, the second cover is buckled on the front end of the treatment device main body, the annular frame is located inside the second cover, and the second cover is threadedly connected with the annular frame.

[0008] In order to facilitate and timely add medicine to the medicine cartridge, the improved drug supply assembly further comprises a drug delivery tank, the upper end of the medicine cartridge is fixedly provided with a medicine inlet pipe, the lower end of the drug delivery tank is fixedly provided with a medicine outlet pipe, a sealing sleeve is fixedly arranged on the outer wall of the medicine inlet pipe, the medicine inlet pipe is inserted into the inside of the medicine outlet pipe, and the sealing sleeve is located between the medicine outlet pipe and the medicine inlet pipe, a plug rod is fixedly arranged at the center of the medicine inlet pipe, the bottom end of the plug rod is provided with a reinforcing rod, the outer end of the reinforcing rod is fixedly arranged on the inner wall of the medicine inlet pipe, a fixed shell is fixedly arranged at the upper end of the drug delivery tank, the inside of the fixed shell is provided with a cavity, a spring is arranged in the inside of the cavity, the upper end of the spring is fixedly arranged at the top of the cavity, a vertical rod is arranged in the inside of the drug delivery tank, the lower end of the vertical rod is provided with a stop block inserted into the inside of the medicine outlet pipe, a limiting plate is fixedly arranged at the upper end of the stop block, the limiting plate is located above the medicine outlet pipe, the upper end of the vertical rod penetrates through the drug delivery tank and is inserted into the inside of the cavity, and the upper end of the vertical rod is fixedly arranged at the lower end of the spring.

[0009] Further, the improved drug supply assembly further comprises a drug supply assembly, the stop block is tightly attached to the inner wall of the medicine outlet pipe, the limiting plate is tightly attached to the upper end of the medicine outlet pipe, the lower end of the fixed shell is tightly attached to the upper end of the drug delivery tank, and the lower end of the fixed shell is provided with an annular plate, the annular plate is fixedly arranged on the upper end of the drug delivery tank through a screw, and the pressure relief block is tightly attached to the inner wall of the pressure relief groove.

[0010] In order to facilitate the operation of the rotating shaft, the improved drug supply assembly further comprises a drug supply assembly, the rotating shaft is fixedly arranged with a rocker at one end outside the main body of the treatment device.

[0011] In order to facilitate the fixation of the position of the rotating shaft, the improvement of the present application is that the one end of the rotating shaft located outside the main body of the treatment device is also provided with a disc which can rotate outside the main body of the treatment device, and the disc is provided with a locking rod which penetrates through the disc and abuts against the main body of the treatment device at one end, and the locking rod is threadedly connected with the disc.

[0012] In order to make the structure placed more stable, the improvement of the present application is that the lower end of the main body of the treatment device is provided with a plurality of height-adjustable support assemblies, and the support assembly comprises a bottom block, a base and a support rod, the support rod is fixed at the upper end of the base, and the support rod is inserted into the bottom block and is threadedly connected with the bottom block.

[0013] (Three) beneficial effects Compared with the prior art, the present application provides a KD01 adenovirus glioma treatment device for inhibiting CDCA8, which has the following beneficial effects: The pressure control structure composed of the pressure relief box, the pressure relief block and the lifting assembly realizes dynamic adjustment of the drug delivery pressure through the real-time feedback of the pressure detector. When the pressure is too high, the pressure is automatically expanded and relieved, and when the pressure is too low, the pressure is actively contracted and stabilized, completely solving the problem of pressure fluctuation of traditional devices, avoiding damage to brain tissue caused by high pressure or insufficient drug delivery caused by low pressure, and ensuring the safety and effectiveness of treatment in the fragile intracranial environment.

[0014] The pipe collecting assembly realizes orderly coiling and storage of the drug delivery catheter through the cooperation of the rotating shaft, the circular baffle and the rocker, so that winding and knotting in the carrying and storage process is avoided. The catheter is stored in the inside of the treatment device main body and protected by the second cover, reducing the pollution probability of exposure, and relying on the toughness of the catheter itself to avoid excessive bending during unwinding and winding, reducing the risk of blockage and improving the operation efficiency. BRIEF DESCRIPTION OF DRAWINGS

[0015] Figure 1 It is a first perspective view of the structure of the present application; Figure 2 It is a second perspective view of the structure of the present application; Figure 3 It is a front view of the present application; Figure 1 It is a first perspective view of the structure of the present application; Figure 4 It is a second perspective view of the structure of the present application; Figure 5 It is an installation structure diagram of the blocking block in the present application; Figure 6 It is an installation structure diagram of the pressure relief block in the present application. Figure 7

[0016] ​In the figure: 1, treatment device main body; 2, bottom block; 3, base; 4, support rod; 5, display screen; 6, control panel; 7, control module; 8, handle; 9, opening; 10, first cover; 11, through hole; 12, administration catheter; 13, second cover; 14, ring frame; 15, disc; 16, rocker; 17, locking rod; 18, pivot; 19, circular baffle; 20, bottom plate; 21, cartridge; 22, liquid level gauge; 23, administration tank; 24, medicine inlet pipe; 25, insertion rod; 26, sealing sleeve; 27, medicine discharge pipe; 28, fixing shell; 29, cavity; 30, spring; 31, vertical rod; 32, stop block; 33, limiting plate; 34, medicine supply pump; 35, first catheter; 36, medicine outlet pipe; 37, pressure relief tank; 38, lifting assembly; 39, pressure relief groove; 40, pressure relief block; 41, cylindrical pipe; 42, first adapter pipe; 43, pressure detector; 44, second adapter pipe; 45, support frame. DETAILED DESCRIPTION

[0017] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative work fall within the scope of protection of the present application.

[0018] Please refer to Figures 1-7 The present application provides a KD01 adenovirus glioma treatment device for inhibiting CDCA8, which comprises a treatment device main body 1, a control module 7 arranged at the upper end of the treatment device main body 1, a display screen 5 and a control panel 6 arranged at one side of the treatment device main body 1, a through hole 11 arranged at the front end of the treatment device main body 1, and an administration catheter 12 penetrating through the through hole 11; a medicine supply assembly is arranged in the treatment device main body 1, and the medicine supply assembly comprises a bottom plate 20, a cartridge 21, a medicine supply pump 34, and a pipe collecting assembly; the cartridge 21, the medicine inlet pipe 24, the medicine supply pump 34, and the pipe collecting assembly are all fixed to the upper end of the bottom plate 20, the bottom plate 20 is fixed to the inside of the treatment device main body 1, one side of the cartridge 21 is provided with a liquid level gauge 22, the liquid level gauge 22 is connected to the display screen 5 through an electrical signal, the medicine inlet end of the medicine supply pump 34 is communicated with the cartridge 21 through a first catheter 35, the medicine outlet end of the medicine supply pump 34 is provided with a medicine outlet pipe 36, the upper end of the medicine outlet pipe 36 is provided with a pressure relief tank 37, the inside of the pressure relief tank 37 is provided with a pressure relief groove 39 communicated with the medicine outlet pipe 36, the pressure relief block 40 is slidably arranged in the pressure relief groove 39, the upper end of the pressure relief tank 37 is fixedly provided with a lifting assembly 38, the output end of the lifting assembly 38 is provided with a driving rod penetrating through the pressure relief tank 37 and connected to the pressure relief block 40, the medicine supply pump 34 is connected to the control module 7 and the control panel 6 through an electrical signal respectively; The collecting tube assembly comprises a cylindrical tube 41 and a support frame 45 fixed at the upper end of the bottom plate 20, the front end of the cylindrical tube 41 penetrates through the support frame 45 and is rotationally connected with the support frame 45 through a bearing, a first adapter pipe 42 is fixed on one side of the support frame 45, the first adapter pipe 42 is connected with the front end of the cylindrical tube 41 through a rotary joint, a second adapter pipe 44 is fixed on the middle part of the cylindrical tube 41, and two circular baffles 19 are symmetrically fixed on the second adapter pipe 44, one of the circular baffles 19 is provided with a rotating shaft 18 penetrating through the treatment device main body 1, one end of the drug delivery tube 12 located inside the treatment device main body 1 is connected with the second adapter pipe 44, and the drug delivery tube 12 is coiled between the two circular baffles 19, the medicine outlet end of the medicine outlet tube 36 is connected with the first adapter pipe 42 through a second catheter, the first adapter pipe 42 is provided with a pressure detector 43, and the pressure detector 43 is connected with the lifting assembly 38 through an electrical signal.

[0019] The upper end of the treatment device main body 1 is provided with an opening 9, the opening 9 is provided with a first cover 10, the first cover 10 is inserted into the opening 9 and is threadedly connected with the opening 9, the first cover 10 is opened, and the drug delivery tank 23 is conveniently taken out of the treatment device main body 1.

[0020] The rotating shaft 18 is fixedly provided with a rocker 16 at one end outside the treatment device main body 1.

[0021] The rotating shaft 18 is further provided with a disc 15 at one end outside the treatment device main body 1, the disc 15 can rotate outside the treatment device main body 1, the disc 15 is provided with a locking rod 17, the locking rod 17 penetrates through the disc 15 and abuts against the treatment device main body 1 at one end, and the locking rod 17 is threadedly connected with the disc 15.

[0022] The lower end of the treatment device main body 1 is provided with a plurality of height-adjustable support assemblies, the support assembly comprises a bottom block 2, a base 3 and a support rod 4, the support rod 4 is fixed at the upper end of the base 3, and the support rod 4 is inserted into the bottom block 2 and is threadedly connected with the bottom block 2.

[0023] Device preparation and placement: The treatment device is carried to the designated diagnosis and treatment position through the handle 8, the height of the base 3 of the support assembly is adjusted according to the flatness of the placement surface. The lifting is adjusted by the threaded connection of the support rod 4 and the bottom block 2, so that the treatment device main body 1 is stably placed, and a stable foundation is provided for subsequent operation.

[0024] The medicine supply assembly further comprises a medicine supply tank 23, the upper end of the medicine cartridge 21 is fixedly provided with a medicine inlet pipe 24, the lower end of the medicine supply tank 23 is fixedly provided with a medicine outlet pipe 27, a sealing sleeve 26 is fixedly provided on the outer wall of the medicine inlet pipe 24, the medicine inlet pipe 24 is inserted into the inside of the medicine outlet pipe 27, and the sealing sleeve 26 is between the medicine outlet pipe 27 and the medicine inlet pipe 24, a plug rod 25 is fixedly provided at the center of the medicine inlet pipe 24, the bottom end of the plug rod 25 is provided with a reinforcing rod, the outer end of the reinforcing rod is fixed on the inner wall of the medicine inlet pipe 24, the upper end of the medicine supply tank 23 is fixedly provided with a fixed shell 28, the inside of the fixed shell 28 is provided with a cavity 29, the inside of the cavity 29 is provided with a spring 30, the upper end of the spring 30 is fixed on the top of the cavity 29, the inside of the medicine supply tank 23 is provided with a vertical rod 31, the lower end of the vertical rod 31 is provided with a stop block 32 which is inserted into the inside of the medicine outlet pipe 27, the upper end of the stop block 32 is fixedly provided with a limiting plate 33, the limiting plate 33 is above the medicine outlet pipe 27, the upper end of the vertical rod 31 penetrates through the medicine supply tank 23 and is inserted into the inside of the cavity 29, and the upper end of the vertical rod 31 is fixed on the lower end of the spring 30.

[0025] The stop block 32 is tightly attached to the inner wall of the medicine outlet pipe 27, the limiting plate 33 is tightly attached to the upper end of the medicine outlet pipe 27, the lower end of the fixed shell 28 is tightly attached to the upper end of the medicine supply tank 23, and the lower end of the fixed shell 28 is provided with an annular plate which is fixed on the upper end of the medicine supply tank 23 by screws, and the pressure relief block 40 is tightly attached to the inner wall of the pressure relief groove 39.

[0026] (2) Medicine liquid supplement and medicine supply tank 23 replacement: If it is necessary to supplement medicine liquid or replace the medicine supply tank 23, the first cover 10 at the upper end of the treatment device main body 1 is counterclockwise rotated, the medicine supply tank 23 inside the opening 9 is taken out after the opening 9 is opened. The medicine supply tank 23 containing the KD01 adenovirus medicine liquid is put in, the medicine outlet pipe 27 at the lower end of the medicine supply tank 23 is precisely connected with the medicine inlet pipe 24 at the upper end of the medicine cartridge 21, the sealing sleeve 26 is tightly sealed between the two, so as to prevent the medicine liquid from leaking. The plug rod 25 in the medicine inlet pipe 24 cooperates with the reinforcing rod, so as to ensure the stability of the connection structure, when the medicine supply tank 23 is placed, the plug rod 25 will provide an upward thrust to the stop block 32, so that the vertical rod 31 compresses the spring 30, at this time, the medicine liquid in the medicine supply tank 23 will flow into the medicine cartridge 21 through the medicine outlet pipe 27 and the medicine inlet pipe 24, so as to ensure that the medicine liquid flows into the medicine cartridge 21 smoothly according to the requirement, and after the supplement or replacement is completed, the first cover 10 is tightened.

[0027] The front end of the treatment device main body 1 is fixedly provided with an annular frame 14 and a second cover 13, the second cover 13 is buckled on the front end of the treatment device main body 1, the annular frame 14 is inside the second cover 13, and the second cover 13 is threadedly connected with the annular frame 14.

[0028] (3) Medicine supply catheter 12 unfolding and probe installation: The second cover 13 at the front end of the treatment device main body 1 is rotated counterclockwise to separate it from the annular frame 14 and is disassembled to expose the administration catheter 12 stored inside. The locking rod 17 on the disc 15 is counterclockwise to loosen the position fixing of the disc 15, and the cylindrical pipe 41 is rotated with the circular baffle 19 by rotating the shaft 18 through the rocker 16, so that the administration catheter 12 wound between the two circular baffles 19 is slowly unwound. The administration catheter 12 relies on its own flexibility to maintain a smooth shape at the second adapter pipe 44 to avoid excessive bending and blockage. After unwinding to the required length, the locking rod 17 is clockwise to lock the disc 15 and fix the position of the shaft 18. Then the special administration probe is installed at the drug outlet end of the administration catheter 12 to complete the preparation of the catheter before administration.

[0029] (Four) Targeted drug delivery and pressure regulation: Start the treatment device, set the drug administration parameters through the control panel 6, and control the operation of each component through the control module 7. After the drug pump 34 is started, the KD01 adenovirus liquid in the cartridge 21 is drawn out through the first catheter 35, delivered to the first adapter pipe 42 through the drug outlet pipe 36, and then delivered to the intracranial tumor lesion area through the administration catheter 12 and the special administration probe.

[0030] During the administration process, the pressure detector monitors the pressure in the pipeline in real time and transmits signals, and the display screen 5 synchronously displays the liquid level state in the cartridge 21, so that the operator can master the liquid level and pressure in real time. When the pressure in the pipeline is too high, the lifting assembly 38 is started to drive the pressure relief block 40 to rise in the pressure relief groove 39, thereby expanding the effective volume of the drug outlet pipe 36 and relieving the pressure peak. When the pressure decreases, the lifting assembly 38 drives the pressure relief block 40 to descend, thereby reducing the volume of the drug outlet pipe 36 and maintaining the stability of the administration pressure, so as to ensure that the liquid is delivered at a uniform rate.

[0031] (Five) Treatment completion and device storage: After a single treatment is completed, the drug pump 34 is turned off, the special administration probe is disassembled, and then the device is disinfected and sterilized. The locking rod 17 is loosened counterclockwise, the rocker 16 is reversed, and the circular baffle 19 is rotated through the shaft 18 to re-wind the administration catheter 12 between the two circular baffles 19, so as to avoid messy winding of the catheter. After the storage is completed, the second cover 13 is buckled at the front end of the treatment device main body 1 and is fixed by screwing with the annular frame 14. If the administration catheter 12 has reached the limited reuse times, it is directly disassembled and replaced at the second adapter pipe 44 to ensure the safety and reliability of subsequent use.

[0032] The administration tank 23 is precisely connected with the medicine cartridge 21 through the medicine inlet pipe 24 and the medicine discharge pipe 27, and multiple seals are formed by the sealing sleeve 26 to prevent liquid leakage. The threaded connection design of the first cover 10 facilitates quick opening and replacement of the administration tank 23, and the coordinated structure of the vertical rod 31, the stop block 32 and the spring 30 ensures smooth liquid delivery, greatly simplifies the medicine adding process, and improves the convenience of clinical operation.

[0033] The height-adjustable support assembly is connected with the bottom block 2 through the threaded connection of the support rod 4, which can flexibly adapt to different flatness of the placement surface, so that the treatment device main body 1 always maintains a stable state. No matter in the operating table, bedside or other diagnosis and treatment scenes, it can provide a stable basis for drug administration operation and avoid affecting the accuracy of drug administration due to placement shaking.

[0034] The display screen 5 displays the liquid level and pressure data in the medicine cartridge 21 in real time, the control panel 6 can conveniently set the drug administration parameters, and the control module 7 coordinates the operation of various components. The operation logic is clear and easy to understand. Without complex debugging, medical staff can quickly get started, adapt to various clinical scenes such as real-time drug administration during operation and emergency treatment at bedside.

[0035] The administration catheter 12 adopts a separate and exclusive use mode, which limits the number of reuse to avoid structural fatigue, and at the same time ensures the cleanliness of the liquid through multiple sealing structures. It effectively reduces the risk of cross infection, improves the safety and compliance of the treatment process, and meets the requirements of clinical aseptic operation.

[0036] In this document, the term "embodiment" means that the specific features, structures or characteristics described in connection with the embodiment can be included in at least one embodiment of the application. The term "embodiment" appearing in various places in the specification does not necessarily refer to the same embodiment, and does not particularly limit its independence or association with other embodiments. In principle, in this application, as long as there is no technical contradiction or conflict, each technical feature mentioned in each embodiment can be combined in any way to form a corresponding implementable technical solution.

[0037] Unless otherwise defined, the meaning of the technical terms used herein is the same as that generally understood by those skilled in the art to which the application belongs; the use of related terms herein is only for the purpose of describing specific embodiments, and is not intended to limit the application.

[0038] Although embodiments of the application have been shown and described, those of ordinary skill in the art can understand that various changes, modifications, replacements and variations can be made to these embodiments without departing from the principles and spirits of the application.

Claims

1. A KD01 adenovirus glioma therapeutic device for inhibiting CDCA8, comprising a therapeutic device main body (1), the upper end of the therapeutic device main body (1) is provided with a control module (7), one side of the therapeutic device main body (1) is provided with a display screen (5) and a control panel (6), characterized in that: The front end of the treatment device body (1) is provided with a through hole (11) and a drug delivery catheter (12) penetrating the through hole (11); The treatment device body (1) is provided with a drug supply assembly, which comprises a bottom plate (20), a drug cartridge (21), a drug supply pump (34) and a pipe collecting assembly. The drug cartridge (21), the drug inlet pipe (24), the drug supply pump (34) and the pipe collecting assembly are all fixed to the upper end of the bottom plate (20), and the bottom plate (20) is fixed to the inside of the treatment device body (1). One side of the drug cartridge (21) is provided with a liquid level meter (22), and the liquid level meter (22) is connected to the display screen (5) through an electrical signal. The drug inlet end of the drug supply pump (34) is connected to the drug cartridge (21) through a first catheter (35). The drug outlet end of the drug supply pump (34) is provided with a drug outlet pipe (36), and the upper end of the drug outlet pipe (36) is provided with a pressure relief tank (37). The inside of the pressure relief tank (37) is provided with a pressure relief groove (39) connected to the drug outlet pipe (36). The inside of the pressure relief groove (39) is slidably provided with a pressure relief block (40). The upper end of the pressure relief tank (37) is fixedly provided with a lifting assembly (38). The output end of the lifting assembly (38) is provided with a drive rod penetrating the pressure relief tank (37) and connected to the pressure relief block (40). The drug supply pump (34) is connected to the control module (7) and the control panel (6) through an electrical signal, respectively. The pipe collecting assembly comprises a cylindrical pipe (41) and a support frame (45). The support frame (45) is fixed to the upper end of the bottom plate (20). The front end of the cylindrical pipe (41) penetrates the support frame (45) and is rotatably connected to the support frame (45) through a bearing. One side of the support frame (45) is fixedly provided with a first adapter pipe (42). The first adapter pipe (42) is connected to the front end of the cylindrical pipe (41) through a rotary joint. The middle part of the cylindrical pipe (41) is fixedly provided with a second adapter pipe (44). Two circular baffles (19) are symmetrically fixed to the second adapter pipe (44). The outside of one of the circular baffles (19) is provided with a rotating shaft (18) penetrating the treatment device body (1). One end of the drug delivery catheter (12) located inside the treatment device body (1) is connected to the second adapter pipe (44). The drug delivery catheter (12) is wound between the two circular baffles (19). The drug outlet end of the drug outlet pipe (36) is connected to the first adapter pipe (42) through a second catheter. The first adapter pipe (42) is provided with a pressure detector (43). The pressure detector (43) is connected to the lifting assembly (38) through an electrical signal.

2. The KD01 adenovirus glioma therapeutic for inhibiting CDCA8 according to claim 1, characterized in that: The upper end of the treatment device body (1) is provided with an opening (9). The opening (9) is provided with a first cover (10). The first cover (10) is inserted into the opening (9) and is threadedly connected to the opening (9).

3. The KD01 adenovirus glioma therapeutic for inhibiting CDCA8 according to claim 2, characterized in that: The front end of the treatment device body (1) is fixedly provided with an annular frame (14) and a second cover (13). The second cover (13) is buckled to the front end of the treatment device body (1). The annular frame (14) is located inside the second cover (13), and the second cover (13) is threadedly connected to the annular frame (14).

4. The KD01 adenovirus glioma therapeutic for inhibiting CDCA8 according to claim 3, characterized in that: The medicine supply assembly further comprises a medicine supply tank (23), the upper end of the medicine cartridge (21) is fixedly arranged with a medicine inlet pipe (24), the lower end of the medicine supply tank (23) is fixedly arranged with a medicine discharge pipe (27), a sealing sleeve (26) is fixedly arranged on the outer wall of the medicine inlet pipe (24), the medicine inlet pipe (24) is inserted into the inside of the medicine discharge pipe (27), and the sealing sleeve (26) is between the medicine discharge pipe (27) and the medicine inlet pipe (24).

5. The KD01 adenovirus glioma therapeutic for inhibiting CDCA8 according to claim 4, characterized in that: The center of the medicine inlet pipe (24) is fixedly arranged with a plug rod (25), the bottom end of the plug rod (25) is provided with a reinforcing rod, the outer end of the reinforcing rod is fixed on the inner wall of the medicine inlet pipe (24), the upper end of the medicine supply tank (23) is fixedly arranged with a fixed shell (28), the inside of the fixed shell (28) is provided with a cavity (29), the inside of the cavity (29) is provided with a spring (30), the upper end of the spring (30) is fixed on the top of the cavity (29), the inside of the medicine supply tank (23) is provided with a vertical rod (31), the lower end of the vertical rod (31) is provided with a stop block (32) inserted into the inside of the medicine discharge pipe (27), the upper end of the stop block (32) is fixedly arranged with a limiting plate (33), the limiting plate (33) is above the medicine discharge pipe (27), the upper end of the vertical rod (31) penetrates through the medicine supply tank (23) and is inserted into the inside of the cavity (29), and the upper end of the vertical rod (31) is fixed on the lower end of the spring (30).

6. The KD01 adenovirus glioma therapeutic for inhibiting CDCA8 according to claim 5, characterized in that: The stop block (32) is tightly attached to the inner wall of the medicine discharge pipe (27), the limiting plate (33) is tightly attached to the upper end of the medicine discharge pipe (27), the lower end of the fixed shell (28) is tightly attached to the upper end of the medicine supply tank (23), and the lower end of the fixed shell (28) is provided with an annular plate, the annular plate is fixed on the upper end of the medicine supply tank (23) by screws, and the pressure relief block (40) is tightly attached to the inner wall of the pressure relief groove (39).

7. The KD01 adenovirus glioma therapeutic for inhibiting CDCA8 according to claim 6, characterized in that: The end of the rotating shaft (18) located outside the treatment device main body (1) is fixedly arranged with a rocker (16).

8. The KD01 adenovirus glioma therapeutic for inhibiting CDCA8 according to claim 7, characterized in that: The end of the rotating shaft (18) located outside the treatment device main body (1) is further provided with a disc (15), the disc (15) can rotate outside the treatment device main body (1), the disc (15) is provided with a locking rod (17), the locking rod (17) penetrates through the disc (15) and abuts against the treatment device main body (1) at one end, and the locking rod (17) is threadedly connected with the disc (15).

9. The KD01 adenovirus glioma therapeutic for inhibiting CDCA8 according to claim 8, characterized in that: The lower end of the treatment device main body (1) is provided with a plurality of height-adjustable support assemblies, the support assembly comprises a bottom block (2), a base (3) and a support rod (4), the support rod (4) is fixed on the upper end of the base (3), and the support rod (4) is inserted into the inside of the bottom block (2) and is threadedly connected with the bottom block (2).

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