A device for treating depression based on acute intermittent hypoxia adenosine induction

Abstract

The application discloses a kind of based on acute intermittent hypoxia adenosine induction depression treatment device, including intermittent hypoxia generator and with its communication positive pressure breathing mask;The intermittent hypoxia generator includes nitrogen generator, air compressor;The output line of the nitrogen generator is merged with the output line of the air compressor and then connected to breathing air pipe, and the positive pressure breathing mask is communicated;The nitrogen generator provides constant pressure for its output line, and the nitrogen flow of its output line is controlled using flow valve;The air compressor provides constant pressure for its output line, and the air flow of its output line is controlled using flow valve;The output line pressure of the nitrogen generator is the same as the output line pressure of the air compressor and higher than ambient atmospheric pressure;The positive pressure breathing mask has sealing ring that fits human face.The present application can realize low oxygen-normal oxygen switching, induce adenosine generation, and obtain exact antidepressant treatment effect.

Description

Technical Field

[0001] This invention belongs to the field of medical devices, and more specifically, relates to a device for treating depression based on acute intermittent hypoxia adenosine-induced depression. Background Technology

[0002] Hypoxia-noroxic cycle control devices are commonly used in biological experiments, such as the chronic intermittent hypoxia control device disclosed in Chinese patent document CN108458251A; and high- and low-oxygen training to improve oxygen metabolism capacity, resist hypoxia physiological and biochemical adaptation, such as Chinese patent document CN215084728U. However, intermittent hypoxia training is a training method that simulates the physiological effects of high-altitude environments by periodically exposing the human body to a hypoxic environment and then restoring it to a normoxic state, triggering the body's adaptive response and improving overall health and athletic performance. Currently, intermittent hypoxia training devices focus more on the process from hypoxia to hyperoxygen, slowly and steadily adjusting the oxygen partial pressure in the breathing atmosphere.

[0003] Research has found that the adenosine signaling pathway is the "master switch" for rapid treatment of depression. Through precisely controlled hypoxia-noroxygen cycling, the brain can be safely and controllably induced to release adenosine, activating the antidepressant pathway (Chenyu Yue et al., "Adenosine Signaling Drives Antidepressant Actions of Ketamine and ECT"). This completely non-invasive, drug-free, and side-effect-free method is suitable for patients with depression of all ages, including treatment-resistant depression unresponsive to medication. Currently, there are no suitable intermittent hypoxia control devices for treating depression, and intermittent hypoxia training devices cannot achieve definitive therapeutic effects for depression. Summary of the Invention

[0004] To address the aforementioned deficiencies or improvement needs of existing technologies, this invention provides a depression treatment device based on acute intermittent hypoxia-adenosine induction. Its purpose is to supply an air source to a positive pressure breathing mask through an intermittent hypoxia generator that stably and sensitively adjusts the oxygen partial pressure, creating a breathing atmosphere that rapidly switches between hypoxia and normoxic conditions. This enables a depression treatment device that can effectively induce adenosine production, thereby solving the technical problem that existing intermittent hypoxia training devices cannot accurately and sensitively change the oxygen partial pressure in the breathing atmosphere, making it difficult to accurately induce adenosine production.

[0005] To achieve the above objectives, according to one aspect of the present invention, a device for treating depression based on acute intermittent hypoxia adenosine-induced depression is provided, comprising an intermittent hypoxia generator and a positive pressure breathing mask connected thereto.

[0006] The intermittent hypoxia generator includes a nitrogen generator and an air compressor;

[0007] The output pipe of the nitrogen generator merges with the output pipe of the air compressor and is connected to the breathing tube, which in turn connects to the positive pressure breathing mask.

[0008] The nitrogen generator provides a constant pressure to its output pipeline and uses a flow valve to control the nitrogen flow rate in its output pipeline; the air compressor provides a constant pressure to its output pipeline and uses a flow valve to control the air flow rate in its output pipeline; the output pipeline pressure of the nitrogen generator is the same as that of the air compressor and is higher than the ambient atmospheric pressure.

[0009] The positive pressure breathing mask has a sealing ring that fits snugly against the human face.

[0010] Preferably, in the acute intermittent hypoxic adenosine-induced depression treatment device, a pressure reducing valve, a flow valve, and a flow meter are sequentially arranged in the airflow direction on the output pipeline of the nitrogen generator; and / or

[0011] The air compressor's output pipeline is equipped with a pressure reducing valve, a flow valve, and a flow meter in sequence according to the airflow direction;

[0012] The pressure reducing valve on the output line of the nitrogen generator has the same set pressure as the pressure reducing valve on the output line of the air compressor.

[0013] Preferably, in the treatment device for depression based on acute intermittent hypoxia adenosine-induced depression, the air pressure in the breathing tubing of the positive pressure breathing mask is higher than atmospheric pressure.

[0014] Preferably, the device for treating depression based on acute intermittent hypoxia adenosine-induced depression has a positive pressure breathing mask equipped with a one-way valve and / or a breathing buffer bag.

[0015] Preferably, the positive pressure breathing mask of the device for treating depression based on acute intermittent hypoxia adenosine is equipped with a pressure sensor.

[0016] The positive pressure breathing mask is equipped with a two-position three-way valve on its breathing tube; the output pipe of the nitrogen generator and the output pipe of the air compressor are connected to the air inlet of the two-position three-way valve, the output port of the two-position three-way valve is connected to the positive pressure breathing mask, and its exhaust port is connected to the ambient atmosphere.

[0017] The pressure sensor measures the air pressure inside the positive pressure breathing mask. When the measured value is greater than a preset threshold, the output port of the two-position three-way valve is connected to the exhaust port; otherwise, the input port of the two-position three-way valve is connected to the output port.

[0018] Preferably, the intermittent hypoxia generator of the depression treatment device based on acute intermittent hypoxia adenosine-induced depression further includes a mixing tank.

[0019] The output pipe of the nitrogen generator is connected to the mixing tank;

[0020] The output pipeline of the air compressor is connected to the mixing tank;

[0021] The mixing tank is connected to the breathing tube of the positive pressure breathing mask.

[0022] Preferably, in the treatment device for depression based on acute intermittent hypoxia adenosine-induced depression, the volume of the mixing tank is less than or equal to 1L.

[0023] Preferably, the device for treating depression based on acute intermittent hypoxia adenosine-induced depression further includes a host computer and a physiological indicator monitor.

[0024] The host computer is connected to the signal output terminal of the physiological indicator monitor.

[0025] The output terminal of the host computer is connected to the control terminal of the flow valve in the output pipeline of the nitrogen generator; the output terminal of the host computer is also connected to the control terminal of the flow valve in the output pipeline of the air compressor.

[0026] Preferably, in the acute intermittent hypoxic adenosine-induced depression treatment device, the host computer controls the output pipeline flow valve of the nitrogen generator and / or the output pipeline flow valve of the air compressor according to a preset program, so as to switch the gas environment inside the positive pressure breathing mask between a hypoxic atmosphere and a normal oxygen atmosphere.

[0027] Preferably, the device for treating depression based on acute intermittent hypoxia adenosine-induced depression has a positive pressure breathing mask with a breathing kit.

[0028] The breathing kit includes a bacterial filter; the bacterial filter, breathing buffer bag, one-way valve, and / or breathing sensor are integrated into the breathing kit.

[0029] In summary, compared with the prior art, the above-described technical solutions conceived by this invention can achieve the following beneficial effects:

[0030] The present invention provides a device for treating depression based on acute intermittent hypoxia and adenosine induction. This device employs a nitrogen generator to provide a stable nitrogen source. The nitrogen generator provides a constant pressure to its output pipeline, ensuring pressure balance even when the flow rates of nitrogen and air are adjusted. This ensures that the oxygen partial pressure after mixing nitrogen and air is precisely and sensitively adjusted to the target oxygen partial pressure. By precisely and sensitively adjusting the oxygen partial pressure of the gas source, combined with a relatively closed positive pressure breathing mask, the controllable changes in the oxygen partial pressure of the gas source are effectively transmitted to the breathing mask, creating an accurate and controllable breathing atmosphere. This achieves an acute switch from hypoxia to normoxic conditions, inducing adenosine production and obtaining a definite antidepressant therapeutic effect.

[0031] In a preferred embodiment, the depression treatment device based on acute intermittent hypoxia adenosine-induced depression provided by the present invention controls the pressure of each stage of the pipeline and sets valves for pressure regulation, forcing the gas in the breathing mask to flow in one direction, minimizing the re-inhalation of exhaled high carbon dioxide gas, and preventing false positive results in physiological monitoring.

[0032] Furthermore, by actively controlling the pressure of the breathing circuit through the pressure detection of the breathing mask, the tidal volume of patients with different tidal volumes can be adapted, alleviating the accumulation of air volume and improving the sensitivity of the oxygen partial pressure adjustment in the breathing atmosphere. Attached Figure Description

[0033] Figure 1 This is a system structure diagram of the depression treatment device based on acute intermittent hypoxia adenosine-induced depression provided by the present invention;

[0034] Figure 2 This is a schematic diagram of the structure of the depression treatment device based on acute intermittent hypoxia adenosine-induced depression provided by the present invention;

[0035] Figure 3 This is a schematic diagram of the intermittent hypoxia generator structure of the depression treatment device provided by the present invention;

[0036] Figure 4 This is a schematic diagram of the positive pressure breathing mask structure of the depression treatment device provided by the present invention;

[0037] Figure 5 This is a structural diagram of the depression treatment device system provided in an embodiment of the present invention.

[0038] In all the accompanying drawings, the same reference numerals are used to denote the same elements or structures, wherein: 1 is an intermittent hypoxia generator, 2 is a positive pressure breathing mask, 21 is a breathing trachea, 22 is a two-position three-way valve, and 23 is a breathing kit. Detailed Implementation

[0039] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative and not intended to limit the invention. Furthermore, the technical features involved in the various embodiments of this invention described below can be combined with each other as long as they do not conflict with each other.

[0040] Studies have found that adenosine is expressed as oxygen concentration decreases from high to low, remains relatively stable during periods of hypoxia, and then decreases sharply during the recovery from hypoxia to normoxia. Existing and simulated high-altitude hypoxia training devices adjust oxygen partial pressure more gradually to ensure safety during exercise. The mechanism by which adenosine secretion is induced in a resting state differs from current hypoxia adaptation training devices. Intermittent hypoxia devices designed for hypoxia adaptation training cannot achieve the rapid cyclical stimulation of hypoxia-noroxic breathing atmospheres required for the treatment of depression, which is a direct reason why they cannot achieve definitive treatment for depression.

[0041] To achieve acute high- and low-oxygen environment switching and induce adenosine secretion for the treatment of depression, this invention provides a depression treatment device based on acute intermittent hypoxia-induced adenosine secretion, such as... Figure 1 As shown, it includes an intermittent hypoxia generator 1, a positive pressure breathing mask 2, a physiological indicator monitor, and a host computer.

[0042] The intermittent hypoxia generator 1 and the positive pressure breathing mask 2 are connected, such as Figure 2 As shown; the host computer is connected to the signal output terminal of the physiological indicator monitor; the output terminal of the host computer is connected to the control terminal of the intermittent hypoxia generator 1, specifically, the output terminal of the host computer is connected to the control terminal of the output pipeline flow valve of the nitrogen generator; the output terminal of the host computer is also connected to the control terminal of the output pipeline flow valve of the air compressor. In this invention, in order to achieve rapid switching between hypoxic and normoxic breathing atmospheres, the intermittent hypoxia generator 1 needs to provide a gas mixing scheme with stable pressure and rapid oxygen concentration adjustment, while the gas path needs to be kept sealed to reduce or even avoid the influence of the ambient atmosphere on the breathing atmosphere.

[0043] The intermittent hypoxia generator 1, such as Figure 3 As shown, the system includes a nitrogen generator, an air compressor, and preferably a mixing tank. It employs a strategy of mixing high-purity nitrogen with air to achieve acute high- and low-oxygen switching. The gas flow rate can be controlled via a flow valve. Precise control of the mixed gas concentration is required. While accurately controlling the gas flow rate, it is also necessary to maintain stable and identical pressures for both gas streams. Otherwise, backflow or turbulence at the junction will lead to inaccurate recording of the high-purity nitrogen or air volume by the flow meter. This invention combines a nitrogen generator as a high-purity nitrogen source, avoiding the use of cheaper but less precise nitrogen tanks. It precisely controls the gas source pressure, and pressure-reducing valves are installed on the output pipelines of both gas sources to further ensure equivalent gas source pressures and accurate flow meter readings.

[0044] The output pipe of the nitrogen generator and the output pipe of the air compressor are connected to the breathing tube 21, which is connected to the positive pressure breathing mask 2;

[0045] The nitrogen generator provides a constant pressure to its output pipeline, and a flow valve controls the nitrogen flow rate in the output pipeline. Specifically, a pressure reducing valve, a flow valve, and a flow meter are sequentially installed on the output pipeline of the nitrogen generator according to the airflow direction. The nitrogen generator is either a nitrogen generator based on membrane separation principle or a nitrogen generator based on molecular sieve principle. Since the inlet of the nitrogen generator needs to be connected to compressed air, it can be designed by combining the output pipeline of an air compressor into two parts, or a separate air compressor can be used to provide compressed air.

[0046] The air compressor provides a constant pressure to its output pipeline and uses a flow valve to control the air flow in its output pipeline; specifically, a pressure reducing valve, a flow valve and a flow meter are sequentially installed on the output pipeline of the nitrogen generator in accordance with the airflow direction.

[0047] The output pipeline pressure of the nitrogen generator is the same as that of the air compressor and is higher than the ambient atmospheric pressure.

[0048] In a preferred embodiment, the output pipe of the nitrogen generator is connected to the mixing tank; the output pipe of the air compressor is also connected to the mixing tank; the mixing tank is connected to the breathing tube 21 of the positive pressure breathing mask 2, and the volume of the mixing tank is less than or equal to 1L. Using a mixing tank for gas mixing reduces pressure fluctuations during mixing. Even if there is a slight pressure difference between the two gas sources, it can reduce backflow caused by pressure imbalance and accurately control the oxygen concentration in the gas. However, the design of the mixing tank provides a certain buffer for the mixed gas, reducing the sensitivity to changes in oxygen partial pressure and making the oxygen partial pressure change range during high and low oxygen switching smoother. A smaller volume mixing tank is used to mitigate this effect.

[0049] The positive pressure breathing mask 2, such as Figure 4 As shown, a sealing ring conforms to the human face and is used for high and low oxygen breathing atmosphere stimulation in the treatment of depression. This requires rapid switching between high and low oxygen concentrations, necessitating strict control of the breathing atmosphere. However, high and low oxygen training devices typically used for hypoxia adaptation training have low requirements for the sensitivity of oxygen concentration adjustment in the breathing atmosphere, thus often employing open breathing masks to improve the experience. These are unsuitable for the breathing atmosphere adjustment sensitivity required for depression treatment. This invention uses a well-sealed positive pressure breathing mask 2 to isolate the ambient atmosphere. A specific concentration of gas from an intermittent hypoxia generator 1 rapidly forms a breathing atmosphere, inducing adenosine production. The breathing tubing pressure of the positive pressure breathing mask 2 is higher than atmospheric pressure. The positive pressure breathing mask 2 is equipped with a one-way valve and / or a breathing buffer bag, and a pressure sensor. Preferably, the positive pressure breathing mask 2 also has a bacterial filter. The bacterial filter, breathing buffer bag, one-way valve, and / or breathing sensor are integrated into the breathing kit 23.

[0050] In a preferred embodiment, the breathing tube 21 of the positive pressure breathing mask 2 is equipped with a two-position three-way valve 22; the output pipe of the nitrogen generator and the output pipe of the air compressor are connected to the air inlet of the two-position three-way valve 22, the output port of the two-position three-way valve 22 is connected to the positive pressure breathing mask 2, and its exhaust port is connected to the ambient atmosphere.

[0051] For precise and sensitive induction of acute intermittent hypoxia in the treatment of depression, in addition to accurately and sensitively adjusting the oxygen partial pressure concentration of the supplied gas, minimizing the backflow of exhaled gas into the gas supply is also an important influencing factor. The concentration of carbon dioxide in exhaled gas may also be one of the determining factors for the induction of adenosine secretion. Considering the reduction of the impact of immediate backflow, a one-way valve is installed on the breathing mask. The preferred solution is to add a breathing buffer bag to the breathing tubing 21, so that the exhaled gas with high carbon dioxide can only be discharged through the one-way valve and cannot flow back into the breathing tubing 21. In addition, since a positive pressure breathing mask 2 is used, the pressure in the breathing tubing is always higher than the ambient atmospheric pressure, and usually also higher than the pressure in the lungs. The supply volume is greater than the tidal volume, and the air pressure in the breathing tubing and positive pressure breathing mask 2 rises slowly. Without a one-way valve design or if the one-way valve cannot be activated in time, the continuous accumulation of the tidal volume difference in the well-sealed airway can lead to respiratory distress. To address this issue, a pressure sensor is installed at the breathing end, specifically on the positive pressure breathing mask 2, to monitor the pressure inside the mask. When the pressure increases, the pressure in the breathing tubing is released by controlling the two-position three-way valve 22, allowing the mixed gas at the end to be discharged into the atmosphere. This not only achieves adaptive tidal volume but also improves the sensitivity to changes in oxygen partial pressure.

[0052] The host computer controls the output pipeline flow valve of the nitrogen generator and / or the output pipeline flow valve of the air compressor according to a preset program, so as to switch the gas environment inside the positive pressure breathing mask 2 between low oxygen atmosphere and normal oxygen atmosphere.

[0053] The following is an example:

[0054] The depression treatment device based on acute intermittent hypoxia-induced adenosine provided in this embodiment induces the release of adenosine in the brain by rapidly switching from normal air to hypoxic air, and maintains a relatively stable adenosine concentration during the hypoxic air period. This activates antidepressant pathways, thereby achieving the goal of treating depression.

[0055] like Figure 1 , 2 As shown, it includes an intermittent hypoxia generator 1, a positive pressure breathing mask 2, a physiological indicator monitor, and a host computer.

[0056] The intermittent hypoxia generator 1 is connected to the positive pressure breathing mask 2; the host computer is connected to the signal output terminal of the physiological indicator monitor; the output terminal of the host computer is connected to the control terminal of the intermittent hypoxia generator 1, specifically, the output terminal of the host computer is connected to the control terminal of the output pipeline flow valve of the nitrogen generator; the output terminal of the host computer is connected to the control terminal of the output pipeline flow valve of the air compressor.

[0057] The intermittent hypoxia generator 1 includes a nitrogen generator, an air compressor, and a mixing tank. It adopts a strategy of mixing high-purity nitrogen with air to achieve acute high and low oxygen switching. The gas flow rate can be controlled by a flow valve. The output pipeline of the nitrogen generator and the output pipeline of the air compressor are connected to the breathing tube 21 and connected to the positive pressure breathing mask 2. One output of the air compressor is connected to the nitrogen generator, and the other is directly connected to the mixing tank.

[0058] The nitrogen generator's output pipeline is equipped with a pressure reducing valve, a flow valve, and a flow meter arranged sequentially according to the airflow direction. The flow meter is a mass flow meter. The nitrogen generator used in this embodiment is based on membrane separation or molecular sieve principles to separate and purify nitrogen from the air, and then mixes the nitrogen and air in a specific ratio to achieve the corresponding low-oxygen concentration. Two common methods for nitrogen generators are membrane separation and molecular sieve principles (also known as pressure swing adsorption). These devices are portable, do not rely on gas cylinders, and can provide stable pressure, achieving more precise low-oxygen partial pressure control. The nitrogen generator's output pipeline is equipped with a pressure reducing valve, a flow valve, and a flow meter arranged sequentially according to the airflow direction. The flow meter is a mass flow meter.

[0059] The input pipeline pressure of the nitrogen generator is the same as the output pipeline pressure of the air compressor and is higher than the ambient atmospheric pressure; in this embodiment, it is set to 0.35 MPa.

[0060] The output pipe of the nitrogen generator is connected to the mixing tank; the output pipe of the air compressor is connected to the mixing tank; the mixing tank is connected to the breathing tube 21 of the positive pressure breathing mask 2, and the volume of the mixing tank is 1L.

[0061] The positive pressure breathing mask 2 has a sealing ring that fits the human face. The positive pressure mask is used to create a breathing atmosphere at the patient's mouth and nose that can switch between low oxygen and normal air in real time, according to the training program of the host computer.

[0062] The positive pressure breathing mask 2 has a two-position three-way valve 22 on its breathing tube 21. The output pipe of the nitrogen generator and the output pipe of the air compressor are connected to the inlet of the two-position three-way valve 22. The output port of the two-position three-way valve 22 is connected to the positive pressure breathing mask 2, and its exhaust port is connected to the ambient atmosphere. In this embodiment, a two-position three-way valve 22 solenoid valve is used for easy control by the host computer.

[0063] The positive pressure breathing mask 2 also includes a breathing kit 23. In this embodiment, the breathing kit 23 includes a breathing buffer bag, a bacterial filter, a one-way valve, and a pressure sensor for the positive pressure breathing mask 2. The 0.22μm bacterial filter is used to filter bacteria (Escherichia coli, Staphylococcus aureus, etc., 0.5-5μm in size) and fungi in the airway. The breathing buffer bag is used to supplement the air volume during exhalation. The one-way valve prevents exhaled gas from returning to the tubing, causing the patient to re-inhale and resulting in a false positive result of decreased blood oxygenation. The pressure sensor is used to monitor the pressure of the positive pressure breathing mask 2. Excessive pressure can cause the patient to have difficulty exhaling. When the pressure reaches a certain threshold (in this embodiment, it is set to be 300Pa higher than atmospheric pressure, and the pressure sensor uses a differential pressure gauge), the two-position three-way solenoid valve can be opened by the pressure sensor to bypass the output gas to the atmosphere. After the pressure drops, the solenoid valve closes, maintaining the supply of the original airway.

[0064] The physiological indicator monitor is used to monitor biofeedback information, including but not limited to blood oxygen saturation, heart rate, and respiratory rate. By monitoring the subject's blood oxygen saturation, heart rate, and respiratory rate, training at the lowest possible oxygen concentration is attempted while ensuring safety. In this embodiment, the physiological indicator monitor can be a fingertip oxygen sensor or a multi-parameter monitor to monitor the user's blood oxygen saturation, heart rate, and respiratory rate. This data can be uploaded to the host computer's hypoxia training program control system and displayed in a new graphical format. The intermittent hypoxia training plan can be adaptively adjusted based on blood oxygen or heart rate. If the patient's physiological indicators (blood oxygen saturation, heart rate, and respiratory rate) are outside the safe range, an audible and visual alarm is issued on both the host and slave computers, and the hypoxia training is terminated, with normal or hyperoxia air introduced. Acute intermittent hypoxia monitoring parameters include, for example, a blood oxygen saturation threshold of 85%, during which blood oxygen must not fall below 85%. A continuous heart rate monitoring of more than 120 bpm for 15 seconds triggers an audible and visual alarm. A continuous respiratory rate exceeding 50 bpm for 10 seconds triggers an alarm.

[0065] The host computer controls the output pipeline flow valve of the nitrogen generator and the output pipeline flow valve of the air compressor according to a preset program, so as to switch the gas environment inside the positive pressure breathing mask 2 between low oxygen atmosphere and normal oxygen atmosphere.

[0066] In this embodiment, the host computer-based hypoxia training program control system is responsible for inputting the patient's basic information. The training program includes, but is not limited to, training parameters such as hypoxia concentration, hypoxia duration, normal oxygen concentration, normal oxygen duration, and number of cycles. This information is transmitted to the intermittent hypoxia generator via communication interfaces such as serial port, Wi-Fi, and Bluetooth. For example, a training program with a hypoxia concentration range of 15%-9% and a recommended hypoxia duration of 5 minutes is suggested; a normal oxygen concentration of 20.9% and a recommended normal oxygen duration of 3 minutes are suggested; and the number of cycles is suggested to be 6.

[0067] like Figure 5 As shown, the intermittent low-oxygen generator is responsible for separating high-purity nitrogen from the air and then mixing it with the air in proportion according to the required low-oxygen concentration via a mass flow meter. The rapid switching from low-oxygen to normal-oxygen is achieved through a solenoid valve. The essence of nitrogen membrane separation is to utilize the differences in the solubility and diffusion rate of components such as O2 and N2 in the air within the polymer membrane to achieve "fast-permeable components (O2) preferentially permeate, while slow-permeable components (N2) are retained and enriched."

[0068] The intermittent low-oxygen generator consists of an air compressor, a gas pretreatment component (condensation and heating), a gas separation module (membrane separation and molecular sieve), a programmable mass flow meter, a mixing tank, an O2 concentration sensor, a two-position three-way solenoid valve, and other matching one-way valves. The air compressor generates high-pressure gas, which is then dehydrated and heated by the pretreatment component to achieve the gas source conditions required by the nitrogen membrane and molecular sieve. The nitrogen concentration separated by the gas separation module is sensitive to the pressure and temperature of the compressed air, thus requiring a stable pressure source. Compared to gas cylinders, air compressors can maintain stable flow and pressure over a long period, unaffected by the decrease in cylinder pressure over time, ensuring system stability.

[0069] Those skilled in the art will readily understand that the above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. A device for treating depression based on acute intermittent hypoxia adenosine induction, characterized by, The intermittent hypoxia generator and the positive pressure breathing mask connected therewith; The intermittent hypoxia generator comprises a nitrogen generator and an air compressor; The output pipeline of the nitrogen generator and the output pipeline of the air compressor are connected to the breathing gas pipeline of the positive pressure breathing mask; The nitrogen generator provides constant pressure for its output pipeline, and a flow valve is used to control the nitrogen flow of the output pipeline; the air compressor provides constant pressure for its output pipeline, and a flow valve is used to control the air flow of the output pipeline; the pressure of the output pipeline of the nitrogen generator is the same as that of the output pipeline of the air compressor and is higher than the ambient atmospheric pressure; A pressure reducing valve, a flow valve and a flow meter are sequentially arranged on the output pipeline of the nitrogen generator in the direction of gas flow; a pressure reducing valve, a flow valve and a flow meter are sequentially arranged on the output pipeline of the air compressor in the direction of gas flow; the pressure of the pressure reducing valve on the output pipeline of the nitrogen generator is the same as that of the pressure reducing valve on the output pipeline of the air compressor; The positive pressure breathing mask has a sealing ring that fits the human face.

2. The device for treating depression based on acute intermittent hypoxia adenosine induction according to claim 1, characterized in that, The gas pressure in the breathing pipeline of the positive pressure breathing mask is higher than the atmospheric pressure.

3. The device for treating depression based on acute intermittent hypoxia adenosine induction according to claim 1, characterized in that, A one-way valve and / or a breathing buffer bag are arranged on the positive pressure breathing mask.

4. The device for treating depression based on acute intermittent hypoxia adenosine induction according to claim 1, wherein, A pressure sensor is arranged on the positive pressure breathing mask. A two-position three-way valve is arranged on the breathing gas pipeline of the positive pressure breathing mask; the output pipelines of the nitrogen generator and the air compressor are connected to the gas inlet of the two-position three-way valve, and the output port of the two-position three-way valve is connected to the positive pressure breathing mask, and the exhaust port is connected to the ambient atmosphere; The pressure sensor measures the gas pressure in the positive pressure breathing mask; when the measured value is greater than a preset threshold, the output port and the exhaust port of the two-position three-way valve are connected, otherwise the input port and the output port of the two-position three-way valve are connected.

5. The device for treating depression based on acute intermittent hypoxia adenosine induction of claim 1, wherein, The intermittent hypoxia generator further comprises a gas mixing tank; The output pipeline of the nitrogen generator is connected to the gas mixing tank; The output pipeline of the air compressor is connected to the gas mixing tank; The gas mixing tank is connected to the breathing gas pipeline of the positive pressure breathing mask.

6. The device for treatment of depression based on acute intermittent hypoxia adenosine induction according to claim 5, characterized in that, The volume of the gas mixing tank is less than or equal to 1L.

7. The device for treating depression based on acute intermittent hypoxia adenosine induction of claim 1, wherein, An upper computer and a physiological index monitor are further included; The upper computer is connected to the signal output end of the physiological index monitor; The output end of the upper computer is connected to the signal control end of the flow valve of the output pipeline of the nitrogen generator, and the output end of the upper computer is connected to the signal control end of the flow valve of the output pipeline of the air compressor.

8. The device for treatment of depression based on acute intermittent hypoxia adenosine induction according to claim 7, characterized in that, The upper computer controls the flow valve of the output pipeline of the nitrogen generator and / or the flow valve of the output pipeline of the air compressor according to a preset program, so as to switch the gas environment in the positive pressure breathing mask between a hypoxic atmosphere and a normal oxygen atmosphere.

9. The device for treatment of depression based on acute intermittent hypoxia adenosine induction of claim 1, wherein, The positive pressure breathing mask has a breathing kit; The breathing kit comprises a bacterial filter; the bacterial filter, a breathing buffer bag, a one-way valve, and / or a breathing sensor are integrated in the breathing kit.

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