Pseudo-ginseng processing method, pseudo-ginseng processed finished product and application

Abstract

The invention provides a processing method of pseudo-ginseng, a pseudo-ginseng processed finished product and application, and particularly belongs to the technical field of traditional Chinese medicine processing. The processing method of pseudo-ginseng comprises the following steps: mixing pseudo-ginseng with water to obtain a mixture, mixing red yeast rice with the mixture, fermenting at 30 DEG C for 65-75 hours, and drying to obtain a pseudo-ginseng processed finished product. The pseudo-ginseng processed finished product has the functions of dissipating blood stasis and stopping bleeding, relieving swelling and pain, activating blood and tonifying qi, strengthening spleen and eliminating food retention, and dissolving turbidity and lowering lipid; the traditional Chinese medicine can treat traumatic injury, blood stasis and blood stasis pain, such as chest pain, headache, dysmenorrhea and other blood stasis states caused by blood stasis, or blood viscosity increase and other blood stasis states.

Description

TECHNICAL FIELD

[0001] The application belongs to the technical field of traditional Chinese medicine processing, and particularly relates to a processing method of Panax notoginseng, a processed product of Panax notoginseng and application thereof. BACKGROUND

[0002] Panax notoginseng is the dry root of Panax notoginseng of the Araliaceae family, also known as Tianqi, Renshenqiqi, Shenshengqiqi and Wenqi. It has the effects of resolving blood stasis, stopping bleeding, promoting blood circulation and relieving pain. It is used for treating hemorrhage, contusion and injury, blood stasis and swelling pain.

[0003] Panax notoginseng is used as a medicine for the first time in Ming Dynasty “Jilun Miaofang”. “Jilun Miaofang” records that Panax notoginseng has the effects of stopping bleeding, resolving blood stasis, reducing swelling and relieving pain. After that, the record in “Bencaogangmu” is widely spread. The State Pharmacopoeia (2020 edition) records that Panax notoginseng has the effects of stopping bleeding, resolving blood stasis, reducing swelling and relieving pain. It is used for treating contusion and injury, chest pain, blood stasis, amenorrhea, dysmenorrhea, postpartum abdominal pain, sore and swelling pain.

[0004] Regarding the processing of Panax notoginseng, according to the State Pharmacopoeia, Panax notoginseng is used as raw medicinal materials, and only the method of “washing, drying and grinding into fine powder” is recorded, and no other processing method is recorded. The 2020 edition of “Chinese Pharmacopoeia” only stipulates the processing method of raw Panax notoginseng and Panax notoginseng powder, and has not yet included the processing specifications of “cooked Panax notoginseng” (such as steamed Panax notoginseng, fried Panax notoginseng, etc.) or other processing methods of Panax notoginseng. The 2020 edition of “Chinese Pharmacopoeia” only stipulates the processing method of raw Panax notoginseng and Panax notoginseng powder, and has not yet included the processing specifications of steamed Panax notoginseng, fried Panax notoginseng, etc. SUMMARY

[0005] The purpose of the present application is to provide a processing method of Panax notoginseng, a processed product of Panax notoginseng and application thereof. The present application provides a new processing method of Panax notoginseng, and the processed product of Panax notoginseng obtained by the processing method of Panax notoginseng has the functions of resolving blood stasis, stopping bleeding, reducing swelling and relieving pain, promoting blood circulation and benefiting qi, invigorating the spleen, eliminating food accumulation, reducing turbidity and lowering lipid. It can be used for treating contusion and injury, blood stasis and obstruction, blood stasis pain, such as chest pain, headache, dysmenorrhea and other pain caused by blood stasis obstruction, and blood stasis state with high blood viscosity.

[0006] The present application provides a processing method of Panax notoginseng, which comprises the following steps: mixing Panax notoginseng and water to obtain a mixture, mixing Monascus with the mixture, fermenting at 30℃ for 65-75h, drying to obtain a processed product of Panax notoginseng.

[0007] Preferably, the mass ratio of Panax notoginseng and water is 1: (1.2-1.8).

[0008] Preferably, the mass ratio of Panax notoginseng and Monascus is 100: (1-50).

[0009] Preferably, the Sanqi includes crushed Sanqi; and the Hongqu includes crushed Hongqu.

[0010] Preferably, the fermentation time is 72 hours.

[0011] The application also provides application of the processing method in preparation of the Sanqi processed product.

[0012] The application also provides the Sanqi processed product obtained by the processing method.

[0013] The application also provides application of the Sanqi processed product obtained by the processing method or the Sanqi processed product in preparation of a medicine for preventing and / or treating any one or more of hypertension, diabetes and complications thereof, hyperlipidemia, arteriosclerosis, and arteriosclerosis obliterans.

[0014] The application also provides application of the Sanqi processed product obtained by the processing method or the Sanqi processed product in preparation of a medicine for treating acute sprain.

[0015] The application also provides a traditional Chinese medicine preparation including the Sanqi processed product and a pharmaceutically acceptable excipient.

[0016] The application provides a processing method of Sanqi. The Sanqi processed product obtained by the processing method has the functions of removing blood stasis, stopping bleeding, removing swelling and pain, promoting blood circulation to invigorate qi, invigorating the spleen to eliminate food accumulation, and reducing turbidity and lowering lipid; and is used for treating and preventing hypertension, diabetes, complications of diabetes, hyperlipidemia, arteriosclerosis, and arteriosclerosis obliterans. BRIEF DESCRIPTION OF DRAWINGS

[0017] In order to more clearly illustrate the technical solutions in the embodiments of the application or the prior art, the following will briefly introduce the drawings needed in the embodiments. Obviously, the drawings in the following description are only some embodiments of the application, and for those skilled in the art, other drawings can be obtained based on these drawings without creative labor.

[0018] Figure 1 A mixing state diagram before fermentation is provided for the application; Figure 2 A state diagram on the second day of fermentation is provided for the application; Figure 3 a fermentation third day state diagram provided by the present application; Figure 4 a fermentation completion state diagram provided by the present application; Figure 5 a sunching pre-three seven state diagram provided by the present application; Figure 6 a sunching post-three seven processed product diagram provided by the present application. DETAILED DESCRIPTION

[0019] The present application provides a processing method of three seven, comprising the following steps: mixing three seven and water to obtain a mixture, mixing red yeast with the mixture, fermenting at 30℃ for 65-75h, drying to obtain a three seven processed product.

[0020] The present application mixes three seven and water to obtain a mixture. In specific embodiments, the three seven comprises pulverized three seven, i.e., the present application mixes three seven powder and water. In specific embodiments, the particle size of the pulverization is 10-200 mesh. In specific embodiments, the mass ratio of the three seven and water is 1: (1.2-1.8).

[0021] After obtaining the mixture, the present application mixes red yeast with the mixture and ferments at 30℃ for 65-75h. In specific embodiments, the mass ratio of the three seven and red yeast is 100: (1-50), and specifically can be 100:5. In specific embodiments, the red yeast comprises pulverized red yeast, i.e., the red yeast can be red yeast powder. In specific embodiments, the fermentation time can be 72h. In specific embodiments, after fermenting for 65-75h, the subsequent drying can be performed when the surface of the medicine block is covered with red "mold clothes".

[0022] After fermentation, the present application dries to obtain a three seven processed product. In specific embodiments, the drying method comprises sun drying.

[0023] The present application does not have special limitations on the source of three seven and red yeast. The source, properties, efficacy, quality control and safety indicators of red yeast can refer to the 2020 edition of Chinese Pharmacopoeia.

[0024] The 2020 edition of Chinese Pharmacopoeia stipulates the processing of three seven as follows: Processing: three seven powder: take three seven, wash, dry, and grind into fine powder.

[0025] Properties: three seven powder is grayish yellow powder with slight odor and bitter sweet taste.

[0026] The 2020 edition of Chinese Pharmacopoeia only stipulates the processing method of raw three seven and three seven powder, and has not yet included the processing specifications of "cooked three seven" (such as steamed three seven, fried three seven, etc.) or other three seven processing methods.

[0027] The processing method of the present application can change the properties of Panax notoginseng, change raw Panax notoginseng into fermented Panax notoginseng, and retain the functions of Panax notoginseng. Specifically, the processing method of the present application can change the properties of Panax notoginseng, facilitate intestinal absorption, increase Panax notoginseng components, specifically increase red yeast fungus components (pigments, various enzyme components (one of the main functions of spleen-strengthening and accumulation-eliminating food), statin substances (one of the main components of lipid-lowering)), increase lipid-lowering function and spleen-strengthening and accumulation-eliminating function on the basis of the functions of Panax notoginseng in invigorating the spleen and stomach, eliminating accumulation and stopping diarrhea, promoting blood circulation and removing blood stasis. That is, the processed Panax notoginseng product of the present application has the functions of stopping bleeding, removing swelling and pain, promoting blood circulation, benefiting qi, and spleen-strengthening and accumulation-eliminating food, the effects of benefiting qi, promoting blood circulation, and removing blood stasis are enhanced, blood circulation and qi are promoted without damaging normal qi, and lipid-lowering effect is more prominent. The processed Panax notoginseng product obtained by the processing method of the present application is suitable for the treatment and prevention of diseases such as hypertension, diabetes, diabetic complications, hyperlipidemia, arteriosclerosis, and arteriosclerosis obliterans. Moreover, the processing method of the present application increases the variety of processed Panax notoginseng decoction pieces, providing more choices for clinical use. The processed Panax notoginseng product of the present application is a processing method inherited from four generations of ancestors, and is one of the main methods used by ancestors to treat sprains and falls, which has been used for more than 100 years and has reliable curative effect. The test results show that the processed Panax notoginseng product of the present application has good therapeutic effect on acute sprains, and the analgesic effect takes effect quickly, with onset within 30-60 min, and the effect lasts for 3-5 h, and the clinical symptoms improve quickly.

[0028] The present application also provides the use of the processing method described in the above technical solution in the preparation of a processed Panax notoginseng product which retains the functions of Panax notoginseng in stopping bleeding and removing swelling and pain, increases the functions of spleen-strengthening and accumulation-eliminating, and enhances the effects of Panax notoginseng in benefiting qi, promoting blood circulation, removing blood stasis, and reducing turbidity and lowering lipid.

[0029] The present application also provides a processed Panax notoginseng product obtained by the processing method described in the above technical solution. The processed Panax notoginseng product of the present application has the following properties: reddish-brown color, red and white spots on the surface, hard quality; slightly sour, bitter, and sweet in taste; warm in nature; meridians: liver, spleen, stomach, and large intestine; functions: stopping bleeding, removing swelling and pain, promoting blood circulation and benefiting qi, spleen-strengthening and accumulation-eliminating food, reducing turbidity and lowering lipid; indications: sprains and falls, blood stasis, blood stasis pain such as chest pain, headache, and menstrual pain caused by blood stasis, and blood stasis states such as increased blood viscosity. In specific embodiments, the usage and dosage of the processed Panax notoginseng product can be 3-9 g, water decoction, or 3 g of finely ground decoction, 2-3 times a day. The processed Panax notoginseng product of the present application is contraindicated for pregnant women.

[0030] The comparison table of Panax notoginseng powder processing product (prepared according to the 2020 edition of Chinese Pharmacopoeia) and the processed Panax notoginseng product obtained by fermentation of the present application is shown in Table 1: Table 1 Comparison table of Panax notoginseng powder processing product and the processed Panax notoginseng product obtained by fermentation of the present application

[0031] The application also provides use of the prepared product of Panax notoginseng prepared by the preparation method in the above technical solution or the prepared product of Panax notoginseng in the above technical solution in preparation of a drug for preventing and / or treating any one or more of hypertension, diabetes and complications thereof, hyperlipidemia, arteriosclerosis and arteriosclerosis obliterans.

[0032] The application also provides use of the prepared product of Panax notoginseng prepared by the preparation method in the above technical solution or the prepared product of Panax notoginseng in the above technical solution in preparation of a drug for treating acute sprain.

[0033] The application also provides a traditional Chinese medicine preparation, which comprises the prepared product of Panax notoginseng in the above technical solution and a pharmaceutically acceptable excipient. The application does not have special limitations on the dosage form of the traditional Chinese medicine preparation, and a conventional dosage form of traditional Chinese medicine can be used. The application does not have special limitations on the type of the excipient, and a conventional excipient corresponding to a specific dosage form can be used.

[0034] In order to further illustrate the application, a preparation method of Panax notoginseng, a prepared product of Panax notoginseng and applications thereof provided by the application are described in detail below in combination with examples, but they should not be understood as limitations on the protection scope of the application.

[0035] In the examples, Panax notoginseng is provided by Panax notoginseng growers in Pingba Town, Wenshan City, Wenshan Prefecture, Yunnan Province. Red koji is selected from Gutian red koji in Fujian Province.

[0036] Example 1 Panax notoginseng and red koji are ground into fine powder and passed through a 200-mesh sieve. Panax notoginseng powder is mixed with water at a mass ratio of 1:1.5, and the mixture is mixed with red koji (the mass ratio of Panax notoginseng powder to red koji is 100:5) Figure 1 , and the mixture state before fermentation is shown in FIG. 1. Fermentation is carried out at a temperature of 30℃ for 70h (the state on the second day of fermentation is shown in FIG. 2, and the state on the third day of fermentation is shown in FIG. 3). When the surface of the medicine block is covered with red “mold clothes” (the state of completed fermentation is shown in FIG. 4), the medicine block is taken out and dried under sunlight (the state of Panax notoginseng before drying is shown in FIG. 5), to obtain a prepared product of Panax notoginseng (the prepared product of Panax notoginseng after drying is shown in FIG. 6), which is collected and stored for later use. Figure 2 Figure 3 Figure 4 Figure 5 Figure 6

[0037] Example 2 The prepared product of Panax notoginseng after preparation is subjected to mass spectrometry detection, and the ion flow chart of mass spectrometry detection is shown in FIG. 8. The detection component results are shown in Table 2. Figure 1

[0038] Table 2: Full scan results of high-resolution mass spectrometry after fermentation and preparation of Panax notoginseng​​​​​​

[0039] According to the results of Table 1, it can be seen that the new substances produced by the fermentation of Panax notoginseng are ginsenoside Rg1 and ginsenoside Rf. It is shown that the function of Panax notoginseng is added, and the functions of Panax notoginseng are retained because the contents of notoginsenoside R1 and notoginsenoside B1 increase after the fermentation of Panax notoginseng.

[0040] Example 3 Chen, male, 50 years old, farmer. On April 25, 2001, he fell down during work and injured his waist. There were visible blood clots on the waist, pain, limited movement, pale red tongue, and wiry pulse. No fracture signs were observed. Diagnosis: waist sprain. The Panax notoginseng processed product of Example 1 was orally taken, 3 grams each time, 3 times a day. In addition, 30 grams of the Panax notoginseng processed product was soaked in white wine and applied externally to the local area. The pain was relieved after one day of use, and the pain disappeared and the movement was free after 7 days of continuous use, and the patient returned to work.

[0041] Example 4 This example comes from the treatment cases in the outpatient department of Sichuan Province Gulin County Chinese Herbal Medicine Research Institute from February 2001 to October 2001. There are 20 male cases and 10 female cases, with an age of 20-50 years old. All cases have a history of acute sprain and are excluded from bone fracture. They have local pain, swelling, and blood stasis. Among them, 8 cases are waist sprain, 10 cases are foot dorsum sprain, 5 cases are ankle joint sprain, and 7 cases are knee joint sprain. The Panax notoginseng processed product of Example 1 is orally taken, 3 grams each time, 3 times a day. Treatment results: Efficacy determination: recovery: local pain, swelling, and blood stasis symptoms disappear. Effective: local pain, swelling, and blood stasis symptoms are relieved. Invalid: local pain, swelling, and blood stasis symptoms have no change.

[0042] Results: recovery: 20 cases, accounting for 66.7%, effective: 10 cases, accounting for 33.3%, invalid: 0 cases. Total effective rate: 100%.

[0043] Example 5 The Panax notoginseng processed product prepared in Example 1 is used for the treatment of patients with high blood pressure, high blood sugar, and high blood fat.

[0044] Case: Ming, male, 56 years old. Sichuan Province Luzhou City Gulin County People's Court. Suffering from hypertension, diabetes, and hyperlipidemia for more than 10 years. Regularly taking antihypertensive and hypoglycemic drugs for many years. On March 7, 2024, the results of the test were: Triglycerides: 3.58 mmol / L; Cholesterol 6.78 mmol / L; High-density lipoprotein cholesterol: 1.11 mmol / L; Low-density lipoprotein cholesterol: 5.06 mmol / L; Glucose: 10.26 mmol / L.

[0045] On June 22, 2024, 1 kg of the prepared product of Panax notoginseng in Example 1 was made into pills, which were orally taken, 3-5 g at a time, 2-3 times a day. On September 27, 2024, the pills were tested, and the results were as follows: Glucose: 6.96 mmol / L; total cholesterol: 6.21 mmol / L; triglyceride: 4.40 mmol / L; high-density lipoprotein cholesterol: 0.96 mmol / L; and low-density lipoprotein cholesterol: 3.84 mmol / L.

[0046] It can be seen that the glucose decreased by 3.3 mmol / L, the cholesterol decreased by 0.57 mmol / L, the high-density lipoprotein cholesterol decreased by 0.15 mmol / L, and the low-density lipoprotein cholesterol decreased by 1.22 mmol / L.

[0047] According to the results, the co-fermentation of Panax notoginseng and Monascus resulted in multi-level biological transformation reactions, including enzymatic transformation, synthesis of secondary metabolites, and synergistic effect, which had a modifying effect on the structure of notoginsenosides. The prepared product of Panax notoginseng after fermentation had a blood glucose-lowering effect.

[0048] Although the above examples have made a detailed description of the present application, it is only a part of the embodiments of the present application, but not all the embodiments. Other embodiments can be obtained according to the present embodiments without creativity, which are within the protection scope of the present application.

Claims

1. A method for processing Panax notoginseng, characterized in that, Includes the following steps: Panax notoginseng and water are mixed to obtain a mixture. Red yeast rice is then mixed with the mixture and fermented at 30°C for 65-75 hours. After drying, the processed Panax notoginseng product is obtained.

2. The processing method according to claim 1, characterized in that, The mass ratio of Panax notoginseng to water is 1:(1.2~1.8).

3. The processing method according to claim 1, characterized in that, The mass ratio of Panax notoginseng to red yeast rice is 100:(1~50).

4. The processing method according to claim 1, characterized in that, The Panax notoginseng includes crushed Panax notoginseng; the red yeast rice includes crushed red yeast rice.

5. The processing method according to claim 1, characterized in that, The fermentation time is 72 hours.

6. The application of the processing method according to any one of claims 1 to 5 in the preparation of processed Panax notoginseng products that retain the functions of dispersing blood stasis, stopping bleeding, reducing swelling and relieving pain, increase the function of strengthening the spleen and eliminating food stagnation, and enhance the effects of invigorating qi, promoting blood circulation, removing blood stasis and reducing turbidity and lipids.

7. The processed Panax notoginseng product obtained by the processing method according to any one of claims 1 to 5.

8. The processed Panax notoginseng product obtained by the processing method according to any one of claims 1 to 5, or the processed Panax notoginseng product according to claim 7, in the preparation of a medicine for the prevention and / or treatment of any one or more of hypertension, diabetes and its complications, hyperlipidemia, arteriosclerosis, and arterial occlusive disease.

9. The use of the processed Panax notoginseng product obtained by the processing method according to any one of claims 1 to 5 or the processed Panax notoginseng product according to claim 7 in the preparation of a medicine for treating acute sprains.

10. A traditional Chinese medicine preparation, characterized in that, It includes the processed Panax notoginseng product as described in claim 7 and pharmaceutically acceptable excipients.

Images