A processing device for crude heparin sodium

Abstract

The application discloses a processing equipment for crude heparin sodium and belongs to the field of heparin sodium preparation, which comprises a shell, a liquid discharge port arranged at the lower end of the shell, a cover one fixed at the upper end of the shell, a liquid inlet arranged on the cover one, and an adsorption assembly arranged in the shell. The adsorption assembly comprises a plurality of supporting pieces fixed to the inner bottom wall of the shell, a filter cartridge clamped to the upper ends of the supporting pieces, a cavity and a hollow cavity arranged in the filter cartridge, and a cover two fixed to the upper end of the filter cartridge and sealing the cavity. The cavity for placing the resin is arranged in the filter cartridge, the resin is confined in the filter cartridge, direct contact with the high-speed rotating stirring paddle is avoided, and the resin is not damaged by the high-speed rotating stirring paddle. The paddle in the hollow cavity can actively and continuously suck the liquid from the bottom of the filter cartridge, and force the liquid to penetrate the resin bed in the radial direction. The radial flow has a large cross-sectional area, a short path, and a more uniform fluid distribution, and the utilization rate of the resin is higher.

Description

Technical Field

[0001] This invention relates to the field of heparin sodium preparation, and more specifically, to a processing apparatus for crude heparin sodium. Background Technology

[0002] Crude heparin sodium is a mixture of sodium glucosamine sulfate extracted from the small intestinal mucosa of healthy pigs. It belongs to the class of mucopolysaccharides. The processing of crude heparin sodium involves dissociating heparin from the protein complex and removing impurities.

[0003] After enzymatic hydrolysis, inactivation, and filtration of the raw materials, a strongly basic anion exchange resin is needed to adsorb heparin molecules from the raw materials. Most impurities (such as nucleic acids and undigested proteins) are left in the waste liquid and discharged. In existing technologies, the filtrate is generally passed through an adsorption column filled with resin. However, this method leads to low contact efficiency. Therefore, a simple stirred tank adsorption vessel is used to achieve full mixing and contact between the resin and the liquid. Although traditional stirred tank adsorption can improve contact efficiency, there are two fundamental contradictions that are difficult to reconcile: First, extending the stirring time or increasing the rotation speed in pursuit of a high adsorption rate will aggravate resin breakage. Second, if gentle stirring is used to protect the resin, it is easy to cause local accumulation of resin bed and form adsorption dead zones. Moreover, the diffusion process of large molecular weight heparin sodium inside the resin particles is restricted, and it is difficult to achieve both overall adsorption efficiency and resin utilization. Summary of the Invention

[0004] In view of the problems existing in the prior art, the purpose of this invention is to provide a processing device for crude heparin sodium.

[0005] To solve the above problems, the present invention adopts the following technical solution.

[0006] A processing device for crude heparin sodium includes a shell, a drain port at the lower end of the shell, a cover fixed at the upper end of the shell, a liquid inlet on the cover, and an adsorption assembly disposed inside the shell.

[0007] The adsorption assembly includes multiple support members fixed to the bottom wall of the housing, a filter cartridge snapped onto the upper end of the multiple support members, a cavity and a hollow cavity opened inside the filter cartridge, a cover body II fixed to the upper end of the filter cartridge to seal the cavity, a contraction section opened on the inner wall of the hollow cavity, a bracket fixed to the inner wall of the contraction section, a rotating shaft rotatably connected inside the cover body II, and a blade fixed outside the rotating shaft and located in the contraction section, with the lower end of the rotating shaft rotatably connected to the upper end of the bracket, and the upper end of the rotating shaft rotatably connected to the lower end of the cover body II.

[0008] A motor is fixedly connected to the upper end of the cover, and the output shaft of the motor passes through the cover and is connected to the upper end of the rotating shaft.

[0009] Furthermore, a disc is fixedly connected to the outside of the rotating shaft, and a scraper is fixedly connected to the outer surface of the disc, with one side of the scraper in contact with the inner wall of the hollow cavity.

[0010] Furthermore, the cross-section of the cavity is an inverted cone shape.

[0011] Furthermore, the filter cartridge is also connected to a disturbance component, which includes multiple rotating columns disposed inside the cavity, a connecting part connecting the upper ends of the multiple rotating columns to the cover body two, a flow channel opened inside the multiple rotating columns, an air outlet fixed outside the multiple rotating columns and connected to the flow channel, a one-way valve fixed inside the connecting end, multiple connecting ends rotating at the lower ends of the multiple rotating columns and connected to the flow channel, and an air supply part disposed inside the filter cartridge and connected to the connecting end. Each of the multiple support members is provided with a pipe two inside, and the lower end of the shell is provided with an interface connected to the pipe two. The upper ends of the multiple support members are respectively fixed with multiple insertion parts connected to the pipe two, and the insertion parts are inserted into the lower end of the filter cartridge and connected to the air supply part.

[0012] Furthermore, the air supply unit includes multiple pipelines I disposed inside the filter cartridge and connected to the insertion part respectively, multiple docking parts fixed to the bottom wall of the cavity and connected to the multiple pipelines I respectively, multiple pistons fixed to the outer walls of the multiple docking parts respectively, and multiple one-way valves II fixed inside the multiple docking parts. The multiple connecting ends are respectively movably sleeved on the outside of the multiple docking parts, and the inner wall of the connecting end is in close contact with the outer ring of the piston.

[0013] Furthermore, the connecting part includes a rotating part rotatably connected inside the cover body two and a connecting post movably inserted inside the rotating part, with the upper end of the rotating post fixedly connected to the lower end of the connecting post.

[0014] Furthermore, it also includes a drive assembly, which includes multiple gears 2 that are rotatably connected to the upper end of the cover 2 and fixedly sleeved on the outside of multiple rotating parts; multiple gears 1 that are rotatably connected to the upper end of the cover 2 and mesh with the multiple gears 2; a drive shaft whose upper end is rotatably connected to the lower end of the cover and whose lower end is connected to the gears 1; and a motor 2 that is fixedly connected to the upper end of the cover 1 and whose output shaft passes through the cover 1 and is connected to the upper end of the drive shaft.

[0015] Furthermore, it also includes multiple axial moving components that are respectively connected to multiple connecting columns. The axial moving components include a frame fixed to the upper end of the cover body two, multiple inclined flanges one integrally formed on the upper end of the frame, a connecting rod rotatably connected inside the frame, a turntable fixed to the upper end of the connecting rod, and multiple inclined flanges two integrally formed on the lower end of the turntable and cooperating with the inclined flanges one. The lower end of the connecting rod passes through the frame and is fixed to the upper end of the connecting column.

[0016] Furthermore, an elastic reset member is sleeved on the outside of the connecting rod, and the upper end of the elastic reset member is fixedly connected to the inner wall of the bracket, while the lower end of the elastic reset member is in sliding contact with the upper end of the connecting column.

[0017] Furthermore, a connector is provided at the upper end of the turntable, and one end of the connector passes through the turntable, connecting rod, and connecting column and is screwed to the upper end of the rotating column.

[0018] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0019] (1) This scheme has a cavity for placing resin inside the filter cartridge. The resin is confined inside the filter cartridge, avoiding direct contact with the high-speed rotating stirring blades and damage from them. In addition, a hollow cavity is opened in the center of the filter cartridge. The blades inside the hollow cavity can actively and continuously draw the liquid from the bottom of the filter cartridge and force it to penetrate the resin bed radially. The blade speed and hollow cavity structure are optimized, so that the liquid stays in the resin bed for a short time. The cross-sectional area of ​​the radial flow (radiating from the center to the surrounding area) is large and the path is short, and the fluid distribution is more uniform. The radial flow mode transforms the traditional axial long-path diffusion into short-path thin-layer diffusion, reducing the liquid film mass transfer resistance and enabling a high adsorption equilibrium to be achieved in a shorter residence time. The liquid is forced to pass through the pores of the resin bed quickly, which can significantly shorten the adsorption equilibrium time. The boundary layer is greatly thinned. At the same time, the liquid below the shell is continuously drawn into the core area, comes into contact with the resin and is discharged, ensuring the uniformity of the concentration of the entire system and avoiding the concentration gradient of the traditional fixed bed.

[0020] (2) This scheme is equipped with a disturbance component. Multiple rotating columns are set in the cavity, and multiple air outlets are set on the rotating columns. The air outlets discharge gas and act on the resin in the cavity. The bubbles are released from the rotating columns at a low flow rate. Their main direction of movement is blocked by the resin bed and tends to rise and diffuse slowly, rather than being sprayed vertically upward. Its function is mainly to loosen the resin and prevent caking. It has little interference with the horizontal radial flow field. During the rising process, the bubbles will continuously stir and loosen the resin particles to prevent the resin from being crushed and blocked, reduce the resistance of liquid flow penetration, and ensure that the liquid can penetrate the entire resin bed uniformly and stably in the radial direction. When the bubbles rise, local turbulence will be generated. The turbulence will destroy the "liquid film boundary layer" on the surface of the resin particles, making it easier for heparin molecules to contact the adsorption sites of the resin, ensuring that its ion exchange capacity is maximized.

[0021] (3) This solution is equipped with a drive component. The drive component drives the rotating column and the air outlet to rotate slowly. The air outlet contacts the resin and gently moves and turns the resin in the filter cartridge to prevent the resin from sticking or clumping due to long-term operation or liquid surface tension. This ensures that the resin bed always maintains a loose and uniform porous structure, providing an ideal channel for liquid penetration. In conjunction with the bubbles, dead corners can be eliminated to ensure that all resin can participate in adsorption and prevent local saturation.

[0022] (4) This scheme is equipped with an axial movement component. The axial movement component allows the rotating column to move up and down during rotation. When the column moves the connecting end downward to reset, the gas between the connecting end and the docking part is compressed. The compressed gas is discharged through the one-way valve, increasing the gas pressure of the gas outlet. The high-pressure gas is discharged from the gas outlet to form an instantaneous strong jet, which directly impacts the resin near the side wall of the cavity, keeping the resin bed in a loose, porous, and optimal fluidization state. Attached Figure Description

[0023] Figure 1 This is a schematic diagram of the overall structure of the present invention;

[0024] Figure 2 This is a schematic diagram of the drain port and interface structure of the present invention;

[0025] Figure 3 This is an overall sectional view of the present invention;

[0026] Figure 4 This is a schematic diagram of the drive component structure of the present invention;

[0027] Figure 5 This is a schematic diagram of the structure of the turntable, scraper, and disturbance component of the present invention;

[0028] Figure 6 This is a schematic diagram of the axial movement component structure of the present invention;

[0029] Figure 7 For the present invention Figure 6 Enlarged schematic diagram of the structure at point A in the middle;

[0030] Figure 8 This is a schematic diagram of the docking part, piston, one-way valve II, insertion part, and pipeline II of the present invention.

[0031] Figure 9 This is a cross-sectional view of the rotating column of the present invention.

[0032] Explanation of the labels in the diagram:

[0033] 1. Shell; 11. Drain port; 2. Cover body one; 21. Inlet port; 3. Adsorption assembly; 31. Filter cartridge; 32. Support component; 33. Cavity; 34. Cover body two; 35. Hollow cavity; 351. Bracket; 352. Contraction section; 37. Rotating shaft; 38. Motor one; 39. Paddle blade; 4. Disc; 5. Scraper; 6. Agitator assembly; 61. Rotating column; 611. One-way valve one; 612. Flow channel; 62. Air outlet; 63. Connection end; 64. Pipeline 1; 65. Connector; 66. Pipeline 2; 67. Interface; 68. Connecting part; 681. Piston; 69. One-way valve 2; 7. Drive assembly; 71. Motor 2; 72. Drive shaft; 73. Gear 1; 74. Rotating part; 75. Connecting column; 76. Gear 2; 8. Axial movement assembly; 81. Frame; 82. Elastic reset element; 83. Turntable; 831. Inclined flange 1; 832. Inclined flange 2; 84. Connector; 85. Connecting rod. Detailed Implementation

[0034] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative effort are within the scope of protection of the present invention.

[0035] Please see Figures 1 to 9 A processing device for crude heparin sodium includes a shell 1, a drain port 11 opened at the lower end of the shell 1, a cover 2 fixed at the upper end of the shell 1, a liquid inlet 21 opened on the cover 2, and an adsorption assembly 3 disposed inside the shell 1.

[0036] The adsorption assembly 3 includes multiple support members 32 fixed to the bottom wall of the inner shell 1, a filter cartridge 31 snapped onto the upper end of the multiple support members 32, a cavity 33 and a hollow cavity 35 opened inside the filter cartridge 31, a cover 2 34 fixed to the upper end of the filter cartridge 31 to seal the cavity 33 by bolts, a contraction section 352 opened on the inner wall of the hollow cavity 35, a bracket 351 fixed to the inner wall of the contraction section 352, a rotating shaft 37 rotatably connected inside the cover 2 34, and a blade 39 fixed outside the rotating shaft 37 and located in the contraction section 352. The lower end of the rotating shaft 37 is rotatably connected to the upper end of the bracket 351, and the upper end of the rotating shaft 37 is rotatably connected to the lower end of the cover 2.

[0037] The upper end of the cover 2 is fixedly connected to a motor 38, and the output shaft of the motor 38 passes through the cover 2 and is connected to the upper end of the rotating shaft 37.

[0038] The rotating shaft 37 is also fixedly connected to a disc body 4, and a scraper 5 is fixedly connected to the outer surface of the disc body 4. One side of the scraper 5 is in contact with the inner wall of the hollow cavity 35.

[0039] The cross-section of the cavity 33 is an inverted cone shape.

[0040] By adopting the above technical solution, cover 2 is removed from the housing 1, cover 34 is removed from the filter cartridge 31, and the resin used for adsorption is placed into the inverted conical cavity 33. Because the cavity 33 is designed as an inverted cone, and the ion exchange resin expands or contracts in volume under different pH values ​​and salt concentrations, when the resin expansion is hindered, the force direction guides the resin to move towards the wider upper space, reducing sidewall pressure. After placing the resin, cover 34 is tightened onto the filter cartridge 31 with bolts. A sealing ring is provided on the contact side between cover 34 and the filter cartridge 31. Cover 2 is fixed to the housing 1, and the liquid to be treated is introduced through the liquid inlet. The liquid enters the housing 1 through the inlet 21. The motor 38 drives the rotating shaft 37 and the impeller 39 to rotate. The rotation of the impeller 39 draws the liquid below the filter cartridge 31 into the constriction section 352. The liquid then enters the hollow cavity 35 through the constriction section 352 and flows out of the filter cartridge 31 after passing through the resin in the cavity 33. During this process, the resin in the cavity 33 adsorbs heparin molecules in the liquid. In this way, the resin is confined within the filter cartridge 31, avoiding direct contact with the high-speed rotating impeller 39 and preventing damage from it. Furthermore, a [feature / feature] is also provided at the center of the filter cartridge 31. The hollow cavity 35, through the impeller 39 inside, actively and continuously draws liquid from the bottom of the filter cartridge 31, forcing it to radially penetrate the resin bed, allowing the liquid to remain in the resin bed for a short time. In actual operation, a high-frequency circulation adsorption mode can be adopted. For example, the suction pressure generated by the impeller 39 causes the liquid to form a full-cycle circulation of no less than 30 times per hour between the inside and outside of the filter cartridge 31. Although the time for a single radial penetration of the resin bed is short, through continuous circulation, the total adsorption contact time can be flexibly set according to process requirements, generally 4-8 hours, thereby ensuring the large fraction of heparin sodium. Sufficient time is available for the particles to diffuse into the active sites of the resin; the radial flow (radiating from the center outwards) has a large cross-sectional area and a short path, resulting in a more uniform fluid distribution. The radial flow mode transforms the traditional long-path axial diffusion into short-path thin-layer diffusion, reducing the liquid film mass transfer resistance and enabling a higher adsorption equilibrium to be achieved in a shorter residence time; the liquid is forced to pass through the pores of the resin bed quickly, which can significantly shorten the adsorption equilibrium time; the boundary layer is greatly thinned, and the liquid below shell 1 is continuously drawn into the core area, comes into contact with the resin, and is then discharged, ensuring the uniformity of the concentration of the entire system and avoiding the concentration gradient of traditional fixed beds;

[0041] Meanwhile, as the rotating shaft 37 rotates, it can also drive the disc 4 and the scraper 5 to rotate. The rotation of the scraper 5 can clean the inner wall of the filter cartridge 31, preventing blockage. At the same time, the rotation of the scraper 5 also helps to accelerate the speed at which the liquid passes through the resin in the cavity 33. After the adsorption reaches a certain time, the drain port 11 is opened, and the waste liquid can be discharged from the drain port 11. Heparin molecules are adsorbed by the resin. Then the filter cartridge 31 can be taken out and the resin can be washed and eluted for the next step.

[0042] like Figure 2 , Figure 5 , Figure 8 and Figure 9 As shown, the filter cartridge 31 is also connected to a disturbance component 6, which includes multiple rotating columns 61 disposed inside the cavity 33, a connecting part connecting the upper ends of the multiple rotating columns 61 to the cover 34, a flow channel 612 opened inside the multiple rotating columns 61, an air outlet 62 fixed outside the multiple rotating columns 61 and connected to the flow channel 612, a one-way valve 611 fixed inside the connecting end 63, multiple connecting ends 63 respectively rotating at the lower end of the multiple rotating columns 61 and connected to the flow channel 612, and an air supply part disposed inside the filter cartridge 31 and connected to the connecting end 63. Each of the multiple support members 32 is provided with a second pipeline 66, and the lower end of the housing 1 is provided with an interface 67 connected to the second pipeline 66. The upper ends of the multiple support members 32 are respectively fixed with multiple insertion parts 65 connected to the second pipeline 66, and the insertion parts 65 are inserted into the lower end of the filter cartridge 31 and connected to the air supply part.

[0043] The air supply unit includes multiple pipelines 64 disposed inside the filter cartridge 31 and connected to the insertion part 65, multiple docking parts 68 fixed to the bottom wall of the cavity 33 and connected to the multiple pipelines 64, multiple pistons 681 fixed to the outer wall of the multiple docking parts 68, and multiple one-way valves 69 fixed inside the multiple docking parts 68. The multiple connecting ends 63 are movably sleeved on the outside of the multiple docking parts 68, and the inner wall of the connecting end 63 is in close contact with the outer ring of the piston 681.

[0044] The connecting part includes a rotating part 74 rotatably connected inside the cover body 34 and a connecting post 75 movably inserted inside the rotating part 74, with the upper end of the rotating post 61 fixedly connected to the lower end of the connecting post 75.

[0045] By adopting the above technical solution, the gas supply pipeline is connected to the interface 67. The gas in the gas supply pipeline enters the second pipeline 66 from the interface 67. The gas then enters the first pipeline 64 through the second pipeline 66 and the insertion part 65. It then enters the docking part 68 through the first pipeline 64, exits from the second check valve 69 and enters the connection end 63, exits from the first check valve 611 and enters the flow channel 612. The gas in the flow channel 612 is discharged through multiple gas outlets 62. The gas outlet 62 is a flange integrally formed on the outside of the rotating column 61. The flange has a gas outlet that communicates with the flow channel 612, and the outside of the flange is covered with a flexible material (specifically medical-grade polytetrafluoroethylene or silicone, whose Shore hardness is much lower than that of the skeleton hardness of ion exchange resin; this design eliminates hard mechanical friction while maintaining the disturbance effect, reducing the resin loss rate during the operation of this equipment, which is superior to traditional agitators). Multiple gas outlets 62 The flow rate and pressure at the outlet are similar, which can be achieved through gas distributors, uniform air supply ducts, etc., which are mature existing technologies and will not be elaborated here. The gas outlet 62 discharges gas and acts on the resin in the cavity 33. The bubbles are released from the rotating column at a low flow rate. The bubbles are small in diameter and have a low release speed. Their main direction of movement is blocked by the resin bed and tends to rise and diffuse slowly, rather than being sprayed vertically upward. Its function is mainly to loosen the resin and prevent caking. It has little interference with the horizontal radial flow field. During the rising process, the bubbles will continuously stir and loosen the resin particles, prevent the resin from compacting and blocking, reduce the resistance to liquid flow penetration, and ensure that the liquid can penetrate the entire resin bed uniformly and stably in the radial direction. When the bubbles rise, they will generate local turbulence. The turbulence will destroy the "liquid film boundary layer" on the surface of the resin particles, making it easier for heparin molecules to contact the adsorption sites of the resin and ensuring that its ion exchange capacity is maximized.

[0046] like Figure 4 and Figure 6 As shown, it also includes a drive assembly 7, which includes multiple gears 76 that are rotatably connected to the upper end of the cover 2 34 and fixedly sleeved on the outside of multiple rotating parts 74; multiple gears 73 that are rotatably connected to the upper end of the cover 2 34 and mesh with the multiple gears 76; a transmission shaft 72 whose upper end is rotatably connected to the lower end of the cover 2 and whose lower end is connected to the gears 73; and a motor 71 that is fixed to the upper end of the cover 2 and whose output shaft passes through the cover 2 and is connected to the upper end of the transmission shaft 72.

[0047] By adopting the above technical solution, the operation of motor 2 71 can drive gear 1 73 to rotate via transmission shaft 72. The rotation of gear 1 73 drives gear 2 76 and rotating part 74 to rotate. The rotation of rotating part 74 drives connecting column 75 and rotating column 61 to rotate. The rotation of rotating column 61 can cause multiple air outlets 62 to rotate. The air outlets 62 are in contact with the resin (the outside is covered with flexible material to avoid resin breakage caused by mechanical friction). They slowly and gently agitate and turn the resin in filter cartridge 31 to prevent the resin from sticking or clumping due to long-term operation or liquid surface tension. This ensures that the resin bed always maintains a loose and uniform porous structure, providing an ideal channel for liquid penetration. At the same time, when the air outlets 62 agitate the resin, they work in conjunction with air bubbles to eliminate dead corners, ensuring that all resin can participate in adsorption and preventing local saturation.

[0048] like Figure 4 , Figure 6 , Figure 7 and Figure 9 As shown, it also includes multiple axial moving components 8 that are respectively connected to multiple connecting columns 75. The axial moving components 8 include a frame 81 fixed to the upper end of the cover 34, multiple inclined flanges 831 integrally formed on the upper end of the frame 81, a connecting rod 85 rotatably connected inside the frame 81, a turntable 83 fixed to the upper end of the connecting rod 85, and multiple inclined flanges 832 integrally formed on the lower end of the turntable 83 and cooperating with the inclined flanges 831. The lower end of the connecting rod 85 passes through the frame 81 and is fixed to the upper end of the connecting column 75.

[0049] The connecting rod 85 is fitted with an elastic reset member 82, and the upper end of the elastic reset member 82 is fixed to the inner wall of the frame 81, while the lower end of the elastic reset member 82 is in sliding contact with the upper end of the connecting column 75.

[0050] The upper end of the turntable 83 is provided with a connector 84, and one end of the connector 84 passes through the turntable 83, the connecting rod 85, and the connecting column 75 and is screwed to the upper end of the rotating column 61.

[0051] By adopting the above technical solution, when the rotating part 74 and the rotating column 61 rotate, the connecting column 75 drives the connecting rod 85 and the turntable 83 to rotate. When the turntable 83 rotates, the inclined flange 1 831 at its bottom will contact the inclined flange 2 832 on the frame 81, thereby pushing the turntable 83 to move upward. When the turntable 83 moves upward, it drives the connecting column 75 and the rotating column 61 to move upward through the connecting rod 85, and the connecting column 75 will compress the elastic reset member 82. When the inclined flange 1 831 separates from the inclined flange 2 832, the elastic reset member 82 pushes the connecting column 75 and the rotating column 61 to move downward and reset; thus, the air outlet 62 can move up and down, improving the air supply to the tree. The grease is agitated; and when the rotating column 61 moves up and down, it can drive the connecting end 63 to move up and down outside the docking part 68. The inner wall of the connecting end 63 is in contact with the outer ring of the piston 681. When the connecting end 63 moves down to reset, the piston 681 will move upward relative to the inside of the connecting end 63 and squeeze the gas inside the connecting end 63, so that the pressure inside the connecting end 63 increases. The compressed gas is discharged through the one-way valve 611, increasing the outlet pressure of the outlet part 62. The high-pressure gas is discharged from the outlet part 62 to form an instantaneous strong jet, which directly impacts the resin near the side wall of the cavity 33, keeping the resin bed in a loose, porous, and optimal fluidization state.

[0052] Instructions for use: Remove cover 2 from housing 1, remove cover 34 from filter cartridge 31, and place the resin for adsorption into the inverted conical cavity 33. After placing the resin, tighten cover 34 onto filter cartridge 31 with bolts. A sealing ring is provided on the contact side between cover 34 and filter cartridge 31. Fix cover 2 to housing 1. The liquid to be treated enters housing 1 through inlet 21. Motor 38 drives rotating shaft 37 and blade 39 to rotate. The rotation of blade 39 can move filter cartridge 31. The liquid below is drawn into the contraction section 352, and then enters the hollow cavity 35 through the contraction section 352. After passing through the resin in the cavity 33, the liquid flows to the outside of the filter cartridge 31. During this process, the resin in the cavity 33 adsorbs heparin molecules in the liquid. As the rotating shaft 37 rotates, it also drives the disc 4 and the scraper 5 to rotate. The rotation of the scraper 5 cleans the inner wall of the filter cartridge 31. The gas in the gas supply pipe enters the second pipe 66 through the interface 67. The gas flows through pipe 66 and connector 65 into pipe 64, then through pipe 64 into connector 68, exits through check valve 69 and enters connection 63, exits through check valve 611 and enters flow channel 612. The gas in flow channel 612 is discharged through multiple vents 62, which act on the resin in cavity 33. As the bubbles rise, they continuously agitate and loosen the resin particles. Motor 71, through drive shaft 72, drives gear 73 to rotate. The rotation of wheel 73 drives gear 76 and rotating part 74 to rotate. The rotation of rotating part 74 drives connecting column 75 and rotating column 61 to rotate. The rotation of rotating column 61 can cause multiple air outlets 62 to rotate. The air outlets 62 contact the resin and slowly and gently agitate and turn the resin in filter cartridge 31. After the adsorption reaches a certain time, the drain port 11 is opened and the waste liquid can be discharged from the drain port 11. Heparin molecules are adsorbed by the resin. Then the filter cartridge 31 can be taken out and the resin can be washed and eluted for the next step.

[0053] The above description is merely a preferred embodiment of the present invention; however, the scope of protection of the present invention is not limited thereto. Any equivalent substitutions or modifications made by those skilled in the art within the scope of the technology disclosed in the present invention, based on the technical solution and its improved concepts, should be covered within the scope of protection of the present invention.

Claims

1. A processing device for crude heparin sodium, comprising a shell (1), a drain port (11) opened at the lower end of the shell (1), a cover body (2) fixed at the upper end of the shell (1), a liquid inlet (21) opened on the cover body (2), and an adsorption assembly (3) disposed inside the shell (1), characterized in that: The adsorption assembly (3) includes multiple support members (32) fixed to the bottom wall of the inner shell (1), a filter cartridge (31) snapped onto the upper end of the multiple support members (32), a hollow cavity (35) opened inside the filter cartridge (31) and a container (33) for placing resin, a cover body two (34) fixed to the upper end of the filter cartridge (31) to seal the container (33) by bolts, a shrinkage section (352) opened on the inner wall of the hollow cavity (35), a bracket (351) fixed to the inner wall of the shrinkage section (352), a rotating shaft (37) rotatably connected inside the cover body two (34), and a blade (39) fixed outside the rotating shaft (37) and located in the shrinkage section (352), and the lower end of the rotating shaft (37) is rotatably connected to the upper end of the bracket (351), and the upper end of the rotating shaft (37) is rotatably connected to the lower end of the cover body one (2); The upper end of the cover (2) is fixedly connected to the motor (38), and the output shaft of the motor (38) passes through the cover (2) and is connected to the upper end of the rotating shaft (37); The filter cartridge (31) is also connected to a disturbance component (6), which includes multiple rotating columns (61) disposed inside the cavity (33), a connecting part connecting the upper ends of the multiple rotating columns (61) to the cover body (34), a flow channel (612) opened inside the multiple rotating columns (61), an air outlet (62) fixed outside the multiple rotating columns (61) and connected to the flow channel (612), and multiple connecting ends (64) respectively rotating at the lower ends of the multiple rotating columns (61) and connected to the flow channel (612). 3) A one-way valve (611) fixed inside the connecting end (63), an air supply unit set inside the filter cartridge (31) and connected to the connecting end (63), a second pipeline (66) is provided inside each of the multiple support members (32), and an interface (67) connected to the second pipeline (66) is opened at the lower end of the housing (1). A multiple insertion part (65) connected to the second pipeline (66) is fixed at the upper end of each of the multiple support members (32), and the insertion part (65) is inserted into the lower end of the filter cartridge (31) and connected to the air supply unit.

2. The processing equipment for crude heparin sodium according to claim 1, characterized in that: The rotating shaft (37) is also fixed to the outside of a disc (4), and a scraper (5) is fixed to the outer surface of the disc (4). One side of the scraper (5) is in contact with the inner wall of the hollow cavity (35).

3. The processing equipment for crude heparin sodium according to claim 2, characterized in that: The cross-section of the cavity (33) is an inverted cone shape.

4. The processing equipment for crude heparin sodium according to claim 3, characterized in that: The air supply unit includes multiple pipelines (64) disposed inside the filter cartridge (31) and connected to the insertion part (65) respectively, multiple docking parts (68) fixed to the bottom wall of the cavity (33) and connected to the multiple pipelines (64) respectively, multiple pistons (681) fixed to the outer wall of the multiple docking parts (68) respectively, and multiple one-way valves (69) fixed inside the multiple docking parts (68). The multiple connecting ends (63) are respectively movably sleeved on the outside of the multiple docking parts (68), and the inner wall of the connecting end (63) is in close contact with the outer ring of the piston (681).

5. The processing equipment for crude heparin sodium according to claim 4, characterized in that: The connecting part includes a rotating part (74) rotatably connected inside the cover (34) and a connecting post (75) movably inserted inside the rotating part (74), and the upper end of the rotating post (61) is fixedly connected to the lower end of the connecting post (75).

6. The processing equipment for crude heparin sodium according to claim 5, characterized in that: It also includes a drive assembly (7), and the drive assembly (7) includes multiple gears two (76) that are rotatably connected to the upper end of the cover two (34) and fixedly sleeved on the outside of multiple rotating parts (74); multiple gears one (73) that are rotatably connected to the upper end of the cover two (34) and mesh with multiple gears two (76); a transmission shaft (72) whose upper end is rotatably connected to the lower end of the cover one (2) and whose lower end is connected to gears one (73); and a motor two (71) that is fixed to the upper end of the cover one (2) and whose output shaft passes through the cover one (2) and is connected to the upper end of the transmission shaft (72).

7. The processing equipment for crude heparin sodium according to claim 6, characterized in that: It also includes multiple axial moving components (8) that are respectively connected to multiple connecting columns (75). The axial moving components (8) include a frame (81) fixed to the upper end of the cover (34), multiple inclined flanges (831) integrally formed on the upper end of the frame (81), a connecting rod (85) rotatably connected inside the frame (81), a turntable (83) fixed to the upper end of the connecting rod (85), and multiple inclined flanges (832) integrally formed on the lower end of the turntable (83) and cooperating with the inclined flanges (831). The lower end of the connecting rod (85) passes through the frame (81) and is fixed to the upper end of the connecting column (75).

8. The processing equipment for crude heparin sodium according to claim 7, characterized in that: The connecting rod (85) is fitted with an elastic reset member (82), and the upper end of the elastic reset member (82) is fixed to the inner wall of the frame (81), while the lower end of the elastic reset member (82) is in sliding contact with the upper end of the connecting column (75).

9. The processing equipment for crude heparin sodium according to claim 8, characterized in that: The turntable (83) is provided with a connector (84) at its upper end, and one end of the connector (84) passes through the turntable (83), the connecting rod (85), the connecting column (75) and is screwed to the upper end of the rotating column (61).

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