Skin care additive for detergent and application of skin care additive

Abstract

The invention relates to the technical field of washing products, and discloses a skin care additive for a detergent and application of the skin care additive. The skin care additive for the detergent is prepared from the following components in parts by weight: 1 to 45 parts of polyethyleneimine ethoxylate, 1 to 45 parts of collagen peptide and 1 to 10 parts of pentaerythritol polyether polyol. According to the skin care additive, the polyethyleneimine ethoxylate, the collagen peptide and the pentaerythritol polyether polyol are compounded, so that the skin care additive can effectively play a role in a detergent system, the irritation of a detergent can be effectively reduced by utilizing the synergistic effect of the three components, and the detergent is endowed with relatively good skin care and moisturizing effects.

Description

Technical Field

[0001] This invention relates to the field of washing product technology, and in particular to a skin care additive for detergents and its application. Background Technology

[0002] Detergents mainly include three categories: fabric detergents, household cleaning products, and personal care products. Surfactants are the main active ingredients in these products. Anionic surfactants include carboxylates, sulfates, sulfonates, and phosphates. Commonly used surfactants in detergents include sodium alkyl polyoxyethylene ether sulfate, alkyl sulfonates, and sodium alkylbenzene sulfonate. These anionic surfactants are widely used in hand-washing detergents due to their strong cleaning power and low price. However, they are highly irritating and can adhere to and penetrate the stratum corneum during use, damaging its integrity and causing adverse reactions such as rough, dry, and peeling skin, and even itching, redness, and blisters.

[0003] Current methods for reducing detergent irritation primarily focus on developing mild, novel surfactants, such as amphoteric surfactants and nonionic phenotypic surfactants, neglecting the direct protection of hand skin. This results in limited effectiveness in reducing detergent damage to the skin and a tendency for detergent cleaning power to weaken. Chinese patent application CN201410849054.5 discloses an environmentally friendly detergent that, by adding soybean-extracted collagen, can directly protect hand skin, improve skin elasticity, and help reduce detergent damage. However, it has the following drawbacks: during detergent use, the amount of collagen (or collagen peptides) adsorbed on the skin is relatively small. Due to the barrier effect of the stratum corneum, it is difficult to penetrate into the dermis and cannot remain on the skin for a long time, resulting in limited skin care effects. Summary of the Invention

[0004] To address the technical problem of limited skincare effects from collagen peptides added to detergents, this invention provides a skincare additive for detergents and its application. When used in detergents, this skincare additive effectively reduces detergent irritation and imparts better skincare and moisturizing effects.

[0005] The specific technical solution of this invention is as follows: In a first aspect, the present invention provides a skin care additive for detergents, comprising the following components in parts by weight: 1-45 parts of polyethyleneimine ethoxylate, 1-45 parts of collagen peptide, and 1-10 parts of pentaerythritol polyether polyol; wherein the general structural formula of the polyethyleneimine ethoxylate is: .

[0006] This invention utilizes a compound of polyethyleneimine ethoxylate, collagen peptides, and pentaerythritol polyether polyol. The synergistic effect of these three compounds reduces detergent irritation and imparts a better skin-care and moisturizing effect. Specifically: (1) On the one hand, polyethyleneimine ethoxylate and pentaerythritol polyether polyol can synergistically reduce the irritation of detergent: polyethyleneimine ethoxylate is a nonionic polymer with a hyperbranched structure, and pentaerythritol polyether polyol is a nonionic surfactant with a four-branched long-chain polyether structure. During the use of detergent, the polyethyleneimine ethoxylate is first adsorbed onto the skin, and then the polyether structures in the molecules of both molecules are intertwined to form a protective film containing many cross-linked hydrogen bonds on the skin surface, forming a grid structure that prevents irritating components in the detergent (such as anionic surfactants) from being adsorbed on the skin surface, thereby reducing the irritation of the detergent.

[0007] (2) On the other hand, polyethyleneimine ethoxylate and pentaerythritol polyether polyol can synergistically enhance the skin care and moisturizing effect of collagen peptides: During the use of detergent, after polyethyleneimine ethoxylate and pentaerythritol polyether polyol adsorb onto the skin surface and form a protective film, they can utilize the hydrogen bond between themselves and collagen peptides to provide anchor points for the adsorption of collagen peptides, thereby increasing the adsorption amount of collagen peptides. The three working together can effectively prevent water evaporation on the skin surface and exert an external moisturizing effect. Furthermore, the protective film formed on the skin surface by polyethyleneimine ethoxylate and pentaerythritol polyether polyol has both hydrophilic and lipophilic properties. Through electrostatic interaction and the dissolution of liposomes in the stratum corneum, it can change the structure of the stratum corneum and form fine, fluid channels that facilitate the penetration of collagen peptides, thereby promoting the penetration of collagen peptides into the dermis and exerting an internal moisturizing effect.

[0008] Furthermore, the aforementioned synergistic effect is unique to polyethyleneimine ethoxylate and pentaerythritol polyether polyol. When conventional polyether polyols are used instead, they do not possess the unique branched long-chain polyether structure of pentaerythritol polyether polyol, and therefore cannot form cross-linked hydrogen bonds, making it difficult to effectively achieve the aforementioned synergistic effect.

[0009] Preferably, in the general formula of the polyethyleneimine ethoxylate, m:n = 2~5:1.

[0010] When the ratio of m to n in polyethyleneimine ethoxylate (the ratio of -CH2CH2N- segments to -CH2CH2O- segments) is within the above range, polyethyleneimine ethoxylate has a high intramolecular charge density. When combined with pentaerythritol polyether polyol, it has a good effect on changing the structure of the stratum corneum of the skin through electrostatic interaction, and can promote the penetration of collagen peptides on the skin surface to a greater extent, thereby improving the effect of skin care additives in improving the skin care and moisturizing effect of detergents.

[0011] Furthermore, in the general structural formula of the polyethyleneimine ethoxylate, m = 20~30 and n = 6~10.

[0012] Furthermore, in the general structural formula of the polyethyleneimine ethoxylate, m=20 and n=10.

[0013] Furthermore, in the general structural formula of the polyethyleneimine ethoxylate, m=30 and n=6.

[0014] Preferably, the weight-average molecular weight of the collagen peptide is 200~10000 Da.

[0015] Furthermore, the weight-average molecular weight of the collagen peptide is 200~1000 Da.

[0016] Preferably, the pentaerythritol polyether polyol is a pentaerythritol polyoxyethylene ether with a weight average molecular weight of 5000~10000 Da.

[0017] Preferably, the mass ratio of the polyethyleneimine ethoxylate to the pentaerythritol polyether polyol is 0.1 to 4.5:1; and the mass ratio of the total mass of the polyethyleneimine ethoxylate and the pentaerythritol polyether polyol to the mass of the collagen peptide is 0.1 to 10:1.

[0018] The ratio of polyethyleneimine ethoxylate to pentaerythritol polyether polyol affects their synergistic effect, thus influencing the skincare additive's ability to improve detergent irritation and moisturize the skin. When the mass ratio of the two components is within the range of this invention (0.1~4.5:1), effective synergy can be achieved, effectively reducing detergent irritation and improving the skincare and moisturizing effect. However, when the ratio does not conform to the range of this invention, the two components will struggle to form a protective film on the skin surface after compounding, thus failing to effectively prevent the adsorption of irritating components in the detergent to the skin surface and failing to effectively promote the skincare and moisturizing effects of collagen peptides.

[0019] The ratio of the total mass of polyethyleneimine ethoxylate and pentaerythritol polyether polyol to the mass of collagen peptides affects the overall skin-care and moisturizing effect of the skin-care additive. Within the scope of this invention (0.1~10:1), it can impart better skin-care and moisturizing effects to the detergent. However, when the amount of polyethyleneimine ethoxylate and pentaerythritol polyether polyol is too low relative to the collagen peptides, it is difficult to effectively promote the adsorption and penetration of collagen peptides on the skin surface. When the amount of polyethyleneimine ethoxylate and pentaerythritol polyether polyol is too high relative to the collagen peptides, since the moisturizing effect of collagen peptides is better than that of the polyethyleneimine ethoxylate and pentaerythritol polyether polyol compound, it will also have an adverse effect on the overall skin-care and moisturizing effect of the skin-care additive.

[0020] Secondly, the present invention provides the application of the above-mentioned skin care additives in detergents.

[0021] Preferably, the detergent is a liquid detergent or a solid detergent; the detergent includes a detergent base and skin care additives; the detergent base includes anionic surfactants.

[0022] Furthermore, the detergent matrix comprises the following components in parts by weight: 10-15 parts dodecylbenzenesulfonate, 0.5-1.5 parts ethoxylated alkyl sulfate, 3-7 parts anhydrous ethanol, 2-7 parts urea, and 60-70 parts water.

[0023] Further, the detergent matrix comprises the following components in parts by weight: 5-10 parts of dodecylbenzene sulfonate, 1-5 parts of polyethoxylated fatty alcohol, 1-3 parts of ethoxylated alkyl sulfate, 0.1-0.5 parts of triethanolamine, 0.3-1 parts of citrate dihydrate, 0-0.3 parts of preservative, and 70-90 parts of water.

[0024] Further, the detergent matrix comprises the following components in parts by weight: 15-20 parts dodecylbenzene sulfonate, 5-15 parts zeolite, 8-13 parts sodium silicate, 10-15 parts sodium carbonate, 0.1-0.8 parts sodium polyacrylate, and 35-45 parts sodium sulfate.

[0025] Preferably, the skin care additive accounts for 0.001 to 10% of the weight of the detergent.

[0026] Compared with the prior art, the present invention has the following advantages: (1) The skin care additive of the present invention is a compound of polyethyleneimine ethoxylate, collagen peptide and pentaerythritol polyether polyol, which can play an effective role in the detergent system and can effectively reduce the irritation of the detergent by utilizing the synergistic effect between the three components, and give the detergent a better skin care and moisturizing effect. (2) In this invention, by controlling the ratio of -CH2CH2N- segments to -CH2CH2O- segments in polyethyleneimine ethoxylate, the ratio between polyethyleneimine ethoxylate and pentaerythritol polyether polyol, and the ratio of the total mass of polyethyleneimine ethoxylate and pentaerythritol polyether polyol to the mass of collagen peptide, the skin care additive can be further improved in terms of improving the irritation of detergent and the moisturizing effect of skin care. Detailed Implementation

[0027] The present invention will be further described below with reference to embodiments.

[0028] First, this invention relates to a skin care additive for detergents, comprising the following components in parts by weight: 1-45 parts of polyethyleneimine ethoxylate, 1-45 parts of collagen peptide, and 1-10 parts of pentaerythritol polyether polyol; the general structural formula of the polyethyleneimine ethoxylate is: .

[0029] In some specific embodiments, the general structural formula of the polyethyleneimine ethoxylate has m:n = 2~5:1, m = 20~30, and n = 6~10. In one specific embodiment, m = 20 and n = 10; in another specific embodiment, m = 30 and n = 6.

[0030] In some specific embodiments, the weight-average molecular weight of the collagen peptide is 200~10000 Da.

[0031] In some specific embodiments, the pentaerythritol polyether polyol is a pentaerythritol polyoxyethylene ether with a weight average molecular weight of 5000~10000 Da.

[0032] In some specific embodiments, the mass ratio of the polyethyleneimine ethoxylate to the pentaerythritol polyether polyol is 0.1 to 4.5:1.

[0033] In some specific embodiments, the total mass ratio of the polyethyleneimine ethoxylate and pentaerythritol polyether polyol to the collagen peptide is 0.1 to 10:1.

[0034] Second, the present invention relates to a method for preparing the above-mentioned skin care additive, comprising the following steps: mixing polyethyleneimine ethoxylate and collagen peptides, then adding pentaerythritol polyether polyol, mixing well, and obtaining the skin care additive.

[0035] Third, this invention relates to the application of the above-mentioned skin care additives in detergents.

[0036] In some specific embodiments, the skin care additive accounts for 0.001 to 10% of the mass of the detergent.

[0037] In some specific embodiments, the detergent is a liquid detergent or a solid detergent; the detergent includes a detergent base and skin-care additives; the detergent base includes anionic surfactants. Wherein: In one specific embodiment, the detergent matrix comprises the following components in parts by weight: 10-15 parts of dodecylbenzenesulfonate, 0.5-1.5 parts of ethoxylated alkyl sulfate, 3-7 parts of anhydrous ethanol, 2-7 parts of urea, and 60-70 parts of water. In another specific embodiment, the detergent matrix comprises the following components in parts by weight: 5-10 parts of dodecylbenzene sulfonate, 1-5 parts of polyethoxylated fatty alcohol, 1-3 parts of ethoxylated alkyl sulfate, 0.1-0.5 parts of triethanolamine, 0.3-1 parts of citrate dihydrate, 0-0.3 parts of preservative, and 70-90 parts of water. In another specific embodiment, the detergent matrix comprises the following components in parts by weight: 15-20 parts of dodecylbenzene sulfonate, 5-15 parts of zeolite, 8-13 parts of sodium silicate, 10-15 parts of sodium carbonate, 0.1-0.8 parts of sodium polyacrylate, and 35-45 parts of sodium sulfate.

[0038] This invention does not specifically limit the type of detergent. The skin-care additive of this invention can be used in various conventional detergents, including liquid detergents and solid granular detergents, such as laundry soap, dishwashing liquid, fruit and vegetable cleaners, laundry detergent, laundry powder, shower gel, and hand soap. This invention does not specifically limit the preparation method of the detergent; various methods well known to those skilled in the art can be used.

[0039] The present invention will now be described with reference to specific embodiments and comparative examples. It should be understood that these embodiments are for illustrative purposes only and are not intended to limit the scope of the invention.

[0040] In the following embodiments and comparative examples, the general structural formula of the polyethyleneimine ethoxylate used is: .

[0041] The test methods used in the following embodiments and comparative examples are as follows: (1) Skin irritation test: Irritation tests were conducted under simulated laboratory conditions. 2 grams of detergent were dissolved in 1000 mL of regular tap water at a temperature of 25±2℃. Participants (15 men and 15 women) washed their faces in the detergent solution using standard methods, twice daily for 30 minutes each time, for one week. Skin irritation on the hands was scored according to the criteria in Table 1. The scores for erythema and edema were then summed and averaged. Skin irritation assessment: 0–0.4 points indicated no irritation; 0.5–1.9 points indicated mild irritation; 2–4.9 points indicated moderate irritation; and 5–8 points indicated severe irritation.

[0042] Table 1. Stimulation Test Scoring Criteria Erythema No erythema Erythema is barely visible light red bright red purplish-red spots score 0 1 2 3 4 Edema No edema Skin thickening is barely visible The skin is raised and the contours are clear. The edema is about 1mm in size. Edema bulging exceeding 1mm and expanding in area score 0 1 2 3 4 (2) Moisturizing effect test: According to the "Guidelines for Evaluating the Moisturizing Efficacy of Cosmetics," at least 30 healthy volunteers were selected. The testing instrument was a Corneometer CM825, and the testing environment was kept under constant temperature and humidity (20-22℃, 40-60% relative humidity). Participants were required to wash the inside of their forearms. After cleaning, measurement areas were marked on the inside of each forearm, with each test area measuring 3cm × 3cm. Before the test, participants sat quietly in the temperature- and humidity-controlled room for at least 30 minutes, without drinking water, exposing their forearms, avoiding contact, and remaining relaxed. The moisture content (MMV value) of the designated areas on the inside of each participant's left and right arms was measured and recorded. Initial values ​​were measured for each test area. Then, a 0.2wt% sample aqueous solution was evenly applied to the test area using a latex finger cot, with a single application amount of 2mg / cm². 2 After 20 minutes of application, rinse the test area with water for 30 seconds and blot dry with a paper towel. Measure the MMV value of the test area 2 hours after sample use. Tests on the same volunteer were performed by the same personnel.

[0043] Example 1 and Comparative Examples 1-7: The Influence of the Composition of Skin Care Additives on Efficacy The skin care additives in Examples 1 and Comparative Examples 1-7 were prepared by the following steps: S1.1: Weigh each component according to the formula shown in Table 2; S1.2: After mixing polyethyleneimine ethoxylate and collagen peptides evenly, add pentaerythritol polyether polyol (or polyethylene glycol-2000) and mix evenly to obtain a skin care additive.

[0044] Table 2. Skin care additive formulations of Example 1 and Comparative Examples 1-7 Components Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 Comparative Example 7 Example 1 Polyethyleneimine ethoxylate A 5 0 5 5 0 7 0 5 Collagen Peptide A 0 0 0 0 15 15 15 15 Pentaerythritol polyether polyol 0 2 2 0 7 0 0 2 Polyethylene glycol-2000 0 0 0 2 0 0 0 0 In Table 2: the amount of each component is expressed in parts by weight; in polyethyleneimine ethoxylate A, m=6, n=30; the weight average molecular weight of collagen peptide A is 200 Da; pentaerythritol polyether polyol is pentaerythritol polyoxyethylene ether with a weight average molecular weight of 5000 Da.

[0045] The detergents of Examples 1 and Comparative Examples 1-7 were prepared by the following steps: S2.1: Weigh the following raw materials by weight: 14 parts sodium dodecylbenzenesulfonate, 1 part sodium ethoxylated alkyl sulfate, 5 parts anhydrous ethanol, 5 parts urea, 65 parts deionized water, and 10 parts of the skin care additives corresponding to each example and comparative example (in the blank control group, the skin care additives were replaced with an equal amount of deionized water). S2.2: Mix all the raw materials from step S2.1 evenly to obtain the detergent.

[0046] Skin irritation and moisturizing tests were conducted on the blank control group and the detergents of Examples 1 and 7. The results are shown in Table 3.

[0047] Table 3. Detergent performance test results for Example 1 and Comparative Examples 1-7 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 Comparative Example 7 Example 1 Blank control Stimulus rating 1.6 1.7 0 1.8 1.6 1.7 1.5 0 1.8 MMV value (0h) 29.8 30.5 29.8 30.4 30.1 30.2 30.3 30.5 30.0 MMV value (2h) 25.7 26.4 28.6 27.9 25.9 26.1 27.5 36.4 25.4 Based on the test results in Table 3, it can be seen that: (1) The skin care additive in Comparative Example 1 contained only polyethyleneimine ethoxylate, and Comparative Example 2 contained only pentaerythritol polyether polyol. Compared with the blank control group, the irritation score did not decrease significantly, indicating that neither polyethyleneimine ethoxylate nor pentaerythritol polyether polyol alone could effectively reduce the irritation of the detergent. However, the skin care additive in Comparative Example 3 used a combination of polyethyleneimine ethoxylate and pentaerythritol polyether polyol, and the irritation was significantly reduced compared with the blank control group, indicating that the two components could synergistically reduce the irritation of the detergent.

[0048] (2) In Comparative Example 4, the pentaerythritol polyether polyol in Comparative Example 3 was replaced with polyethylene glycol-2000. The irritation of Comparative Example 3 was lower than that of Comparative Example 4 (the irritation of Comparative Example 4 was comparable to that of the blank control group). This indicates that only pentaerythritol polyether polyol containing a branched long-chain polyether structure can produce a synergistic effect in reducing detergent irritation when combined with polyethyleneimine ethoxylate.

[0049] (3) The skincare additive in Comparative Example 7 contained only collagen peptides. Compared with the blank control group, its irritation and moisturizing effects were not significantly improved, indicating that collagen peptides alone could neither effectively reduce detergent irritation nor exert a skincare and moisturizing effect. Comparative Example 5 added polyethyleneimine ethoxylate to Comparative Example 7, and Comparative Example 6 added pentaerythritol polyether polyol to Comparative Example 7. However, the test results showed that the irritation and moisturizing effects of Comparative Examples 5 and 6 were not significantly improved compared with Comparative Example 7, indicating that polyethyleneimine ethoxylate or pentaerythritol polyether polyol alone could not effectively improve the skincare and moisturizing effect of collagen peptides. However, Example 1 added polyethyleneimine ethoxylate and pentaerythritol polyether polyol to Comparative Example 7. Its irritation and moisturizing effects were significantly improved compared with Comparative Examples 5-7 and the blank control group, indicating that polyethyleneimine ethoxylate and pentaerythritol polyether polyol could synergistically improve the skincare and moisturizing effect of collagen peptides.

[0050] Examples 2-6 and Comparative Examples 8-9: Effect of the ratio of polyethyleneimine ethoxylate to pentaerythritol polyether polyol on the effect The skin care additives of Examples 2-6 and Comparative Examples 8-9 were prepared by the following steps: S1.1: Weigh each component according to the formula shown in Table 4; S1.2: After mixing polyethyleneimine ethoxylate and collagen peptides evenly, add pentaerythritol polyether polyol and mix evenly to obtain a skin care additive.

[0051] Table 4. Skin care additive formulations of Examples 2-6 and Comparative Examples 8-9 Components Comparative Example 8 Example 2 Example 3 Example 4 Example 5 Example 6 Comparative Example 8 Polyethyleneimine ethoxylate A (m a ])]] 0.5 0.55 2 3 4.5 4.9 5 Collagen peptide A (m b )]> 15 15 15 15 15 15 15 pentaerythritol polyether polyols (m c )]> 5.5 5.45 4 3 1.5 1.1 1 m a / m c ]]> 0.09 0.1 0.5 1 3 4.5 5 In Table 4: the amount of each component is expressed in parts by weight; in polyethyleneimine ethoxylate A, m=6, n=30; the weight average molecular weight of collagen peptide A is 200 Da; pentaerythritol polyether polyol is pentaerythritol polyoxyethylene ether with a weight average molecular weight of 5000 Da.

[0052] The detergents of Examples 2-6 and Comparative Examples 8-9 were prepared by the following steps: S2.1: Weigh the following raw materials by weight: 14 parts sodium dodecylbenzenesulfonate, 1 part sodium ethoxylated alkyl sulfate, 5 parts anhydrous ethanol, 5 parts urea, 65 parts deionized water, and 10 parts of the skin care additives corresponding to each example and comparative example (in the blank control group, the skin care additives were replaced with an equal amount of deionized water). S2.2: Mix all the raw materials from step S2.1 evenly to obtain the detergent.

[0053] Skin irritation and moisturizing tests were conducted on the blank control group and the detergents of Examples 2-6 and Comparative Examples 8-9. The results are shown in Table 5.

[0054] Table 5. Detergent performance test results of Examples 2-6 and Comparative Examples 8-9 Comparative Example 8 Example 2 Example 3 Example 4 Example 5 Example 6 Comparative Example 8 Blank control Stimulus rating 1.5 0 0 0 0 0 1.5 1.8 MMV value (0h) 29.8 29.9 30.0 29.8 29.2 30.5 30.4 30.0 MMV value (2h) 25.8 36.8 36.9 36.7 37.4 37.9 27.7 25.4 Based on the test results in Table 5, it can be seen that: The only difference between Examples 2-6 and Comparative Examples 8-9 is the ratio of polyethyleneimine ethoxylate to pentaerythritol polyether polyol in the skincare additive. Compared to Examples 2-6, this ratio in Comparative Examples 8-9 was either too high or too low, resulting in a failure to significantly reduce the irritation of the detergent and improve its skincare and moisturizing effects. The skincare additives in Examples 2-6 showed better effects in improving both detergent irritation and skincare and moisturizing effects, indicating that a good synergistic effect can be achieved when the mass ratio of polyethyleneimine ethoxylate to pentaerythritol polyether polyol is 0.1-4.5:1.

[0055] Examples 7-19: Effect of the ratio of the total mass of polyethyleneimine ethoxylate and pentaerythritol polyether polyol to the mass of collagen peptides on the efficacy. The skincare additives in Examples 7-19 were prepared through the following steps: S1.1: Weigh each component according to the formulas shown in Tables 6 and 7; S1.2: After mixing polyethyleneimine ethoxylate and collagen peptides evenly, add pentaerythritol polyether polyol and mix evenly to obtain a skin care additive.

[0056] Table 6. Skin care additive formulations in Examples 7-13 Components Example 7 Example 8 Example 9 Example 10 Example 11 Example 12 Example 13 Polyethyleneimine ethoxylate A (m a )]> 5.5 1 10 2 2.5 4.5 5 Collagen peptide A (m b ) 1 22 2 40 5 18 5 pentaerythritol polyether polyols (m c ])]] 5.5 1 10 2 2.5 4.5 5 <![CDATA[(m a +m c ) / m b ]]> 11 0.09 10 0.1 1 0.5 2 Table 7. Skin care additive formulations from Examples 14-19 Components Example 14 Example 15 Example 16 Example 17 Example 18 Example 19 <![CDATA[Polyethyleneimine ethoxylate A (m a )]] 5.5 6 10 8 6 10 <![CDATA[Collagen peptide A (m b )]] 44 3 8 36 8 25 <![CDATA[Pentaerythritol polyether polyol (m c )]] 5.5 6 10 8 6 10 <![CDATA[(m a +m c ) / m b ]]> 0.25 4 2.5 0.44 1.5 0.8 In Tables 6 and 7: the amount of each component is expressed in parts by weight; in polyethyleneimine ethoxylate A, m=6, n=30; the weight average molecular weight of collagen peptide A is 200 Da; pentaerythritol polyether polyol is pentaerythritol polyoxyethylene ether with a weight average molecular weight of 10000 Da.

[0057] The detergents in Examples 7-19 were prepared by the following steps: S2.1: Weigh the following raw materials by weight: 8 parts sodium dodecylbenzenesulfonate, 4 parts polyethoxylated fatty alcohol, 2 parts ethoxylated alkyl sulfate, 0.5 parts triethanolamine, 0.6 parts sodium citrate dihydrate, 0.1 parts preservative, 81.8 parts deionized water, and 3 parts of skin care additives corresponding to each example and comparative example (in the blank control group, the skin care additives were replaced with an equal amount of deionized water). S2.2: Mix all the raw materials from step S2.1 evenly to obtain the detergent.

[0058] Skin irritation and moisturizing tests were performed on the blank control group and the detergents of Examples 7-19. The results are shown in Tables 8 and 9.

[0059] Table 8. Detergent performance test results for Examples 7-13 Example 7 Example 8 Example 9 Example 10 Example 11 Example 12 Example 13 Blank control Stimulus rating 0 0 0 0 0 0 0 1.9 MMV value (0h) 30.0 29.8 30.3 30.7 30.4 30.0 30.1 29.6 MMV value (2h) 25.7 25.3 35.8 36.3 36.0 35.7 32.6 25.8 Table 9. Detergent performance test results for Examples 14-19 Example 14 Example 15 Example 16 Example 17 Example 18 Example 19 Blank control Stimulus rating 0 0 0 0 0 0 1.9 MMV value (0h) 30.8 30.2 29.4 29.7 29.6 30.5 29.6 MMV value (2h) 33.3 32.8 37.3 37.8 37.6 34.4 25.8 Based on the test results in Tables 8 and 9, it can be seen that: The only difference between Examples 7-19 is the ratio of the total mass of polyethyleneimine ethoxylate and pentaerythritol polyether polyol to the mass of collagen peptides in the skincare additive. All of these examples effectively reduce the irritation of the detergent. However, compared to Examples 9-19, the ratio in Examples 7-8 is either too high or too low, resulting in an inability to effectively improve the skincare and moisturizing effects of the detergent. The skincare additives in Examples 9-19 show good effects in improving both detergent irritation and skincare and moisturizing effects, indicating that a ratio of the total mass of polyethyleneimine ethoxylate and pentaerythritol polyether polyol to the mass of collagen peptides of 0.1-10:1 can achieve a good synergistic effect in improving the skincare and moisturizing effects of the detergent.

[0060] Examples 20-23: The Influence of the Selection of Polyethyleneimine Polyoxyethylene Ether on the Effect The skincare additives in Examples 20-23 were prepared through the following steps: S1.1: Weigh each component according to the formula shown in Table 10; S1.2: After mixing polyethyleneimine ethoxylate and collagen peptides evenly, add pentaerythritol polyether polyol (or polyethylene glycol-2000) and mix evenly to obtain a skin care additive.

[0061] Table 10 Skin care additive formulations of Examples 20-23 Components Example 20 Example 21 Example 22 Example 23 Polyethyleneimine ethoxylate A 5 0 0 0 Polyethyleneimine ethoxylate B 0 5 0 0 Polyethyleneimine ethoxylate C 0 0 5 0 Polyethyleneimine ethoxylate D 0 0 0 5 Collagen Peptide A 15 15 15 15 Pentaerythritol polyether polyol 2 2 2 2 In Table 10: the amounts of each component are expressed in parts by weight; in polyethyleneimine ethoxylate A, m=6, n=30; in polyethyleneimine ethoxylate B, m=8, n=8; in polyethyleneimine ethoxylate C, m=20, n=10; in polyethyleneimine ethoxylate D, m=30, n=6; the weight-average molecular weight of collagen peptide A is 200 Da; the pentaerythritol polyether polyol is pentaerythritol polyoxyethylene ether with a weight-average molecular weight of 5000 Da.

[0062] The detergents of Examples 20-23 were prepared by the following steps: S2.1: Weigh the following raw materials by weight: 19.7 parts sodium dodecylbenzenesulfonate, 15 parts 4A zeolite, 10 parts sodium silicate, 14 parts sodium carbonate, 0.5 parts sodium polyacrylate, 40.8 parts sodium sulfate, and 0.001 parts of the skin care additives corresponding to each example and comparative example (in the blank control group, the skin care additives were replaced with an equal amount of deionized water). S2.2: Mix all the raw materials from step S2.1 evenly to obtain the detergent.

[0063] Skin irritation and moisturizing tests were conducted on the blank control group and the detergents of Examples 20-23. The results are shown in Table 11.

[0064] Table 11 Detergent performance test results for Examples 20-23 Example 20 Example 21 Example 22 Example 23 Blank control Stimulus rating 0 0 0 0 2.1 MMV value (0h) 29.8 29.7 30.0 30.1 29.8 MMV value (2h) 35.7 35.6 45.5 45.3 24.4 Based on the test results in Table 11, it can be seen that: The only difference between Examples 20-23 is the ratio of m to n (the ratio of -CH2CH2N- segments to -CH2CH2O- segments) of the polyethyleneimine ethoxylate used in the skincare additive. All these examples effectively reduce the irritation of the detergent and improve its skincare and moisturizing effects. Among them, the skincare and moisturizing effects of the detergents in Examples 22-23 are superior to those in Examples 20-21, indicating that a m to n ratio of 2-5:1 in the polyethyleneimine ethoxylate provides the detergent with better skincare and moisturizing properties.

[0065] Examples 24-28: The Influence of the Molecular Weight of Collagen Peptides on the Efficacy The skincare additives in Examples 24-28 were prepared through the following steps: S1.1: Weigh each component according to the formula shown in Table 12; S1.2: After mixing polyethyleneimine ethoxylate and collagen peptides evenly, add pentaerythritol polyether polyol (or polyethylene glycol-2000) and mix evenly to obtain a skin care additive.

[0066] Table 12 Skin care additive formulations of Examples 20 and 24-28 Components Example 20 Example 24 Example 25 Example 26 Example 27 Example 28 Polyethyleneimine ethoxylate A 5 5 5 5 5 5 Collagen Peptide A 15 0 0 0 0 0 Collagen peptide B 0 15 0 0 0 0 Collagen Peptide C 0 0 15 0 0 0 Collagen Peptide D 0 0 0 15 0 0 Collagen Peptide E 0 0 0 0 15 0 Collagen peptide F 0 0 0 0 0 15 Pentaerythritol polyether polyol 2 2 2 2 2 2 In Table 12: the amounts of each component are expressed in parts by weight; in polyethyleneimine ethoxylate A, m=6, n=30; the weight-average molecular weight of collagen peptide A is 200 Da; the weight-average molecular weight of collagen peptide B is 500 Da; the weight-average molecular weight of collagen peptide C is 1000 Da; the weight-average molecular weight of collagen peptide D is 1500 Da; the weight-average molecular weight of collagen peptide E is 5000 Da; the weight-average molecular weight of collagen peptide F is 10000 Da; the pentaerythritol polyether polyol is pentaerythritol polyoxyethylene ether with a weight-average molecular weight of 5000 Da.

[0067] The detergents of Examples 24-28 were prepared by the following steps: S2.1: Weigh the following raw materials by weight: 19.7 parts sodium dodecylbenzenesulfonate, 15 parts 4A zeolite, 10 parts sodium silicate, 14 parts sodium carbonate, 0.5 parts sodium polyacrylate, 40.8 parts sodium sulfate, and 0.001 parts of the skin care additives corresponding to each example and comparative example (in the blank control group, the skin care additives were replaced with an equal amount of deionized water). S2.2: Mix all the raw materials from step S2.1 evenly to obtain the detergent.

[0068] Skin irritation and moisturizing tests were conducted on the blank control group and the detergents of Examples 24-28, and the results are shown in Table 13.

[0069] Table 13 Detergent performance test results for Examples 20 and 24-28 Example 20 Example 24 Example 25 Example 26 Example 27 Example 28 Blank control Stimulus rating 0 0 0 0 0 0 2.1 MMV value (0h) 29.8 30.3 30.4 30.7 30.4 30.5 29.8 MMV value (2h) 35.7 35.8 35.9 33.3 33.0 33.1 24.4 Based on the test results in Table 13, it can be seen that: The only difference between Examples 20 and Examples 24-28 is the molecular weight of the collagen peptides used in the skincare additives. All these examples effectively reduce the irritation of the detergent and improve its skincare and moisturizing effects. Among them, the skincare and moisturizing effects of the detergents in Examples 20, 24, and 25 are superior to those in Examples 26-28, indicating that a collagen peptide molecular weight of 200-1000 Da can impart better skincare and moisturizing effects to the detergent.

[0070] The above are merely preferred embodiments of the present invention and do not limit the patent scope of the present invention. Any equivalent structural or procedural transformations made using the present invention specification, or direct or indirect applications in other related technical fields, are similarly included within the patent protection scope of the present invention.

Claims

1. A skin care additive for detergents, characterized in that, The product comprises the following components in parts by weight: 1-45 parts of polyethyleneimine ethoxylate, 1-45 parts of collagen peptides, and 1-10 parts of pentaerythritol polyether polyol; the general structural formula of the polyethyleneimine ethoxylate is: 。 2. The skincare additive according to claim 1, characterized in that, In the general structural formula of the polyethyleneimine ethoxylate, m:n = 2~5:

1.

3. The skincare additive according to claim 1 or 2, characterized in that, In the general structural formula of the polyethyleneimine ethoxylate, m = 20~30 and n = 6~10.

4. The skincare additive according to claim 1, characterized in that, The weight-average molecular weight of the collagen peptides is 200~10000 Da.

5. The skincare additive according to claim 1, characterized in that, The pentaerythritol polyether polyol is a pentaerythritol polyoxyethylene ether with a weight average molecular weight of 5000~10000 Da.

6. The skincare additive according to claim 1, characterized in that, The mass ratio of the polyethyleneimine ethoxylate to the pentaerythritol polyether polyol is 0.1 to 4.5:1; the mass ratio of the total mass of the polyethyleneimine ethoxylate and the pentaerythritol polyether polyol to the mass of the collagen peptide is 0.1 to 10:

1.

7. The application of the skin care additive according to any one of claims 1 to 6 in detergents.

8. The application according to claim 7, characterized in that, The detergent is a liquid detergent or a solid detergent; the detergent includes a detergent base and skin care additives; the detergent base includes anionic surfactants.

9. The application according to claim 8, characterized in that: The detergent matrix comprises the following components in parts by weight: 10-15 parts dodecylbenzenesulfonate, 0.5-1.5 parts ethoxylated alkyl sulfate, 3-7 parts anhydrous ethanol, 2-7 parts urea, and 60-70 parts water; or, The detergent matrix comprises the following components in parts by weight: 5-10 parts dodecylbenzene sulfonate, 1-5 parts polyethoxylated fatty alcohol, 1-3 parts ethoxylated alkyl sulfate, 0.1-0.5 parts triethanolamine, 0.3-1 parts citrate dihydrate, 0-0.3 parts preservative, and 70-90 parts water; or, The detergent matrix comprises the following components in parts by weight: 15-20 parts dodecylbenzenesulfonate, 5-15 parts zeolite, 8-13 parts sodium silicate, 10-15 parts sodium carbonate, 0.1-0.8 parts sodium polyacrylate, and 35-45 parts sodium sulfate.

10. The application according to claim 7 or 8, characterized in that, The skin care additive accounts for 0.001~10% of the mass of the detergent.

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