Sliding type multi-range volume control device, multi-range pipettor and pipetting method

Abstract

The invention provides a sliding type multi-range volume control device, a multi-range pipettor and a pipetting method. The volume control device comprises at least two pressure generators, a pressure sensor and a controller, the measuring range gear switching assembly is used for switching and controlling the movement of the measuring range feedback pieces on the different pressure generators; the measuring range gear switching assembly is arranged in the middle of the special-shaped supporting bracket, and each pressure generator is arranged on the side edge of the special-shaped supporting bracket; each measuring range feedback piece is movably arranged on the special-shaped supporting bracket, and the pressure generator can penetrate through the measuring range feedback pieces in a sliding manner so as to limit the expansion amount of the pressure generator and realize distribution of preset volumes; one end of each displacement transmission piece is connected with the measuring range gear switching assembly and fixedly connected with the corresponding measuring range feedback piece, and the other end of each displacement transmission piece is rotatably connected with the special-shaped supporting bracket so as to drive the corresponding measuring range feedback piece to move; according to the invention, the distribution of non-integer units of liquid can be realized by only one pipettor.

Description

Technical Field

[0001] This invention relates to the field of liquid dispenser technology, and more particularly to a sliding multi-range volume control device, a multi-range pipette, and a pipetting method. Background Technology

[0002] Existing pipette solutions require frequent changes of pipettes and tips when moving non-integer units of liquid to meet minimum pipetting error requirements. For example, to handle a single volume of 1126.5 µL, three pipettes with capacities of 1000 µL, 200 µL, and 10 µL are needed to sequentially add 1000 µL, 120 µL, and 6.5 µL of reagent to the target container, respectively. This requires changing three different pipette sizes and consuming three disposable plastic tips. Frequent pipette changes make pipetting extremely time-consuming and labor-intensive, and the consumption of a large number of plastic tips is environmentally unfriendly. Having multiple pipettes of different capacities also occupies significant laboratory space and increases manufacturing costs.

[0003] Therefore, there is an urgent need for a sliding multi-range volume control device, a multi-range pipette, and a pipetting method that can achieve rapid and high-precision dispensing of non-integer units of liquid with a single pipette without switching between multiple pipette sizes, thereby ensuring experimental accuracy and improving experimental efficiency. Summary of the Invention

[0004] The purpose of this invention is to provide a sliding multi-range volume control device, a multi-range pipette, and a pipetting method, which aims to solve the technical problem that traditional pipettes cannot achieve rapid and high-precision dispensing of non-integer units of liquid using a single pipette.

[0005] To achieve the above objectives, in a first aspect, the present invention provides a sliding multi-range volume control device, comprising:

[0006] At least two pressure generators with different ranges and accuracy levels are used to generate corresponding pressures, and each pressure generator has the same structure.

[0007] The range switching component has the same number of ranges as the pressure generators, and is used to switch pressure generators of different ranges to generate a feed amount of a preset volume.

[0008] The number of range feedback elements is the same as the number of pressure generators, with one range feedback element corresponding to each pressure generator;

[0009] An irregularly shaped support bracket, wherein the range switching component is disposed in the middle of the irregularly shaped support bracket, and each of the pressure generators is disposed at intervals on the side of the irregularly shaped support bracket;

[0010] Each range feedback element is movably mounted on the irregular support bracket, and its corresponding pressure generator can slide through the range feedback element to limit the extension and retraction of the pressure generator through the range feedback element, thereby realizing the distribution of the preset volume.

[0011] The displacement transmitters are the same number as the pressure generators. One end of each displacement transmitter is connected to the range switching component, passes through the corresponding range feedback component, and is fixedly connected to the corresponding range feedback component. The other end is rotatably connected to the irregular support bracket, so that when the range switching component is switched to the corresponding range, it can drive the corresponding range feedback component to move.

[0012] As a further improvement to the above solution, the pressure generator includes a piston cylinder, a piston rod slidably sleeved in the piston cylinder, a first reset member that provides a reset force to the piston rod, and a feedback pressure cylinder sleeved on the rod end of the piston rod.

[0013] The tactile feedback cylinder is used to transmit tactile pressure to the piston rod, and its tactile fingers contact the corresponding tactile feedback range indicator.

[0014] As a further improvement to the above solution, the range shifting assembly includes a knob, a shifting lever fixedly connected to the knob at one end, a shifting fixing inner ring and a guide wheel inner ring that are alternately sleeved on the outer wall of the shifting lever.

[0015] Each pressure generator is provided with a corresponding inner ring of the guide wheel, and each inner ring of the guide wheel corresponds to a gear position;

[0016] Each of the guide wheel inner rings is further fitted with a guide wheel, and the inner ring of the guide wheel and the middle part of the guide wheel are respectively provided with corresponding locking holes perpendicular to their axis;

[0017] The gear shift lever includes a shift lever body and an elastic locking protrusion disposed on the side of the shift lever body, and the elastic locking protrusion is operablely engaged in the locking hole of the corresponding gear.

[0018] As a further improvement to the above solution, the switching rod body is a cylindrical rod with grooves symmetrically arranged on both sides, and each groove is provided with a limiting spring piece, and the limiting spring piece is provided with the elastic protrusion.

[0019] One end of the gear shift lever is fixedly connected to the knob via a fastener.

[0020] As a further improvement to the above solution, the displacement transmission component is a wire, and the wire is arranged in a closed loop, with one end of the closed loop wrapped around the wire wheel.

[0021] The other end of the closed loop of the conductor passes through the corresponding range feedback element and is rotatably connected to the pulley on the irregular support bracket.

[0022] When passing through the corresponding range feedback element, one side is fixedly connected to the range feedback element, and the other side is slidably connected to the range feedback element.

[0023] As a further improvement to the above solution, the irregular support bracket includes a gear shift bracket, a pressure generator bracket, and a range scale.

[0024] The gear shift bracket is vertically mounted on the top of the pressure generator bracket, and the range scale is vertically fixed to the side of the pressure generator bracket to indicate the movement position of the tactile feedback range indicator.

[0025] As a further improvement to the above solution, the pressure generator bracket includes a first frame and a second frame arranged parallel to each other from top to bottom. The outer wall of the first frame extends outward along its circumference with piston cylinder rod end fasteners corresponding to the number of pressure generators.

[0026] The outer wall of the second frame extends outward along its circumference with piston cylinder rodless end fasteners corresponding to the number of pressure generators;

[0027] The inner wall of the second frame is provided with pulleys corresponding to the number of pressure generators, so that the other end of the displacement transmission component can be rotatably connected;

[0028] Furthermore, a guide rod corresponding to the number of pressure generators is provided between the first frame and the second frame, and each range feedback element is slidably mounted on the corresponding guide rod.

[0029] As a further improvement to the above solution, the gear shifting bracket includes a vertical support column and several horizontal support columns cantilevered on one side of the vertical support column.

[0030] The horizontal support columns are fixedly installed at equal intervals from top to bottom on one side of the vertical support columns;

[0031] Each of the horizontal support columns has a sleeve at its cantilever end, and the sleeves are coaxially arranged. The range switching component is rotatably arranged in each of the coaxially arranged sleeves.

[0032] The cantilever end of the horizontal support column at the lowest position is provided with several guide members along the circumference of its corresponding sleeve to support the displacement transmission member.

[0033] As a further improvement to the above solution, the guide includes a column and a guide ring disposed on the side of the column, and the guide ring is provided with a through hole through which the displacement transmission component slides.

[0034] As a further improvement to the above solution, the range feedback device includes a piston cylinder fixing ring through which the piston cylinder passes. The outer walls of the piston cylinder fixing ring extend outward from opposite sides, and blind holes are provided on the ears along their thickness direction. A second reset device is provided in the blind holes to provide reset force for the touch feedback pressure cylinder.

[0035] The piston cylinder retaining ring is also provided with an irregularly shaped range pointer on its outer wall, which is used to indicate the preset volume feed amount in the current gear.

[0036] In a second aspect, the present invention also provides a control method for the above-mentioned sliding multi-range volume control device, the steps of which include:

[0037] S1: First, pull or push the range switching component to position it in the range corresponding to the first preset volume.

[0038] S2: Rotate the range switching component again to drive the displacement transmission component connected to it to rotate, thereby driving the range feedback component fixedly connected to the displacement transmission component to move linearly until the range feedback component moves to the position corresponding to the first preset volume.

[0039] S3: Pull or push the range switching component again to make it position corresponding to the second preset volume; repeat step S2 to move the corresponding range feedback component to the position corresponding to the second preset volume, and so on, until the corresponding range feedback component of the corresponding position moves to the corresponding preset volume.

[0040] S4: Then, the pressure generators of the corresponding ranges are activated sequentially until the touch finger on each pressure generator touches the corresponding range feedback element to realize the distribution of non-integer units of liquid.

[0041] Thirdly, the present invention also provides a multi-range pipette, including a housing assembly, a sliding multi-range volume control device, a pressure transmission assembly and a mixing control assembly disposed within the housing assembly, and an integrated medicine tank that is detachably disposed from the housing assembly;

[0042] The sliding multi-range volume control device includes a range switching component and at least two pressure generators for generating release pressure or suction pressure. The range switching component has the same number of ranges as the number of pressure generators and is used to switch to the corresponding range so that the corresponding pressure generator generates pressure for the corresponding preset volume.

[0043] The pressure outlets of each pressure generator are connected together to form a total pressure outlet, and the total pressure outlet is connected to the first transmission port of the pressure transmission assembly.

[0044] The second transmission port of the pressure transmission component is connected to the integrated drug tank, and the integrated drug tank is connected to a pipette tip.

[0045] The air outlet of the mixing control component is connected to the integrated drug container, and is used to release mixing pressure to the integrated drug container so that the reagents inside reach a uniform state.

[0046] As a further improvement to the above solution, the multi-range volume control device further includes:

[0047] The number of range feedback elements is the same as the number of pressure generators, with one range feedback element corresponding to each pressure generator;

[0048] Each range feedback element is movably mounted on the irregular support bracket, and its corresponding pressure generator can slide through the range feedback element to limit the extension and retraction of the pressure generator through the range feedback element, thereby realizing the distribution of the preset volume.

[0049] An irregularly shaped support bracket, wherein the range switching component is disposed in the middle of the irregularly shaped support bracket, and each of the pressure generators is disposed at intervals on the side of the irregularly shaped support bracket;

[0050] The displacement transmitters are the same number as the pressure generators. One end of each displacement transmitter is connected to the range switching component, passes through the corresponding range feedback component, and is fixedly connected to the corresponding range feedback component. The other end is rotatably connected to the irregular support bracket, so that when the range switching component is switched to the corresponding range, it can drive the corresponding range feedback component to move.

[0051] As a further improvement to the above scheme, the structures of each pressure generator are identical;

[0052] The pressure generator includes a piston cylinder, a piston rod slidably sleeved in the piston cylinder, a first reset member that provides a reset force to the piston rod, and a feedback pressure cylinder sleeved on the rod end of the piston rod.

[0053] The tactile feedback cylinder is used to transmit tactile pressure to the piston rod, and its tactile fingers contact the corresponding tactile feedback range indicator.

[0054] As a further improvement to the above solution, the range shifting assembly includes a knob, a shifting lever fixedly connected to the knob at one end, a shifting fixing inner ring and a guide wheel inner ring that are alternately sleeved on the outer wall of the shifting lever.

[0055] Each pressure generator is provided with a corresponding inner ring of the guide wheel, and each inner ring of the guide wheel corresponds to a gear position;

[0056] Each of the guide wheel inner rings is further fitted with a guide wheel, and the inner ring of the guide wheel and the middle part of the guide wheel are respectively provided with corresponding locking holes perpendicular to their axis;

[0057] The gear shift lever includes a shift lever body and an elastic locking protrusion disposed on the side of the shift lever body, and the elastic locking protrusion is operablely engaged in the locking hole of the corresponding gear.

[0058] As a further improvement to the above solution, the switching rod body is a cylindrical rod with grooves symmetrically arranged on both sides, and each groove is provided with a limiting spring piece, and the limiting spring piece is provided with the elastic protrusion.

[0059] One end of the gear shift lever is fixedly connected to the knob via a fastener.

[0060] As a further improvement to the above solution, the displacement transmission component is a wire, and the wire is arranged in a closed loop, with one end of the closed loop wrapped around the wire wheel.

[0061] The other end of the closed loop of the conductor passes through the corresponding range feedback element and is rotatably connected to the pulley on the irregular support bracket.

[0062] When passing through the corresponding range feedback element, one side is fixedly connected to the range feedback element, and the other side is slidably connected to the range feedback element.

[0063] As a further improvement to the above solution, the irregular support bracket includes a gear shift bracket, a pressure generator bracket, and a range scale.

[0064] The gear shift bracket is vertically mounted on the top of the pressure generator bracket, and the range scale is vertically fixed to the side of the pressure generator bracket to indicate the movement position of the tactile feedback range indicator.

[0065] As a further improvement to the above solution, the pressure generator bracket includes a first frame and a second frame arranged parallel to each other from top to bottom. The outer wall of the first frame extends outward along its circumference with piston cylinder rod end fasteners corresponding to the number of pressure generators.

[0066] The outer wall of the second frame extends outward along its circumference with piston cylinder rodless end fasteners corresponding to the number of pressure generators;

[0067] The inner wall of the second frame is provided with pulleys corresponding to the number of pressure generators, so that the other end of the displacement transmission component can be rotatably connected;

[0068] Furthermore, a guide rod corresponding to the number of pressure generators is provided between the first frame and the second frame, and each range feedback element is slidably mounted on the corresponding guide rod.

[0069] As a further improvement to the above solution, the gear shifting bracket includes a vertical support column and several horizontal support columns cantilevered on one side of the vertical support column.

[0070] The horizontal support columns are fixedly installed at equal intervals from top to bottom on one side of the vertical support columns;

[0071] Each of the horizontal support columns has a sleeve at its cantilever end, and the sleeves are coaxially arranged. The range switching component is rotatably arranged in each of the coaxially arranged sleeves.

[0072] The cantilever end of the horizontal support column at the lowest position is provided with several guides along the circumference of its corresponding sleeve to support the displacement transmission component.

[0073] As a further improvement to the above solution, the guide includes a column and a guide ring disposed on the side of the column, and the guide ring is provided with a through hole through which the displacement transmission component slides.

[0074] As a further improvement to the above solution, the range feedback device includes a piston cylinder fixing ring through which the piston cylinder passes. The outer walls of the piston cylinder fixing ring extend outward from opposite sides, and blind holes are provided on the ears along their thickness direction. A second reset device is provided in the blind holes to provide reset force for the touch feedback pressure cylinder.

[0075] The piston cylinder retaining ring is also provided with an irregularly shaped range pointer on its outer wall, which is used to indicate the preset volume feed amount in the current gear.

[0076] As a further improvement to the above solution, the pressure transmission assembly includes a positive pressure transmission channel and a negative pressure transmission channel that are coupled together, and can operably transmit release pressure or absorb pressure.

[0077] The negative pressure transmission channel includes a first one-way valve, a first flow guide cavity, and a first bidirectional coupling switch connected in sequence. One end of the first one-way valve is unidirectionally connected to the first interface of the first flow guide cavity, and the second interface of the first flow guide cavity is connected to the first air inlet of the first bidirectional coupling switch. The first bidirectional coupling switch also has two air outlets for communicating with the atmosphere.

[0078] The positive pressure transmission channel includes a second one-way valve, a second flow guide cavity, and a second bidirectional coupling switch connected in sequence. One end of the second one-way valve is unidirectionally connected to the first interface of the second flow guide cavity, and the second interface of the second flow guide cavity is connected to the second air inlet of the first bidirectional coupling switch. The third interface of the second flow guide cavity is connected to the first air inlet of the second bidirectional coupling switch.

[0079] The third interface of the first flow guide cavity is connected to the second air inlet of the second bidirectional coupling switch;

[0080] The first check valve and the second check valve have opposite conduction directions, and the other end of the first check valve and the other end of the second check valve are connected to form the first transmission port.

[0081] The two outlets of the second bidirectional coupling switch are connected to form the second transmission port.

[0082] As a further improvement to the above solution, the mixing control component includes a balloon and a reciprocating pressure member for contacting the balloon. One end of the balloon is connected to an air duct that extends into the integrated drug compartment. The other end of the balloon is connected to a bidirectional coupling switch, which also has an air inlet.

[0083] As a further improvement to the above solution, the outer casing assembly includes a gun body for easy gripping, a medicine cartridge basket secured at the bottom of the gun body, and a pipette tip release assembly disposed on the outer wall of the gun body.

[0084] The pipette tip release assembly is used to remove the pipette tip mounted on the integrated medicine container.

[0085] Fourthly, the present invention also provides a pipetting method for the above-mentioned multi-range pipette, the steps of which include:

[0086] S1: First, adjust the range switching component to the range corresponding to the preset volume, and then uniformly adjust the range feedback component corresponding to each range to the corresponding preset volume position.

[0087] S2: Then switch the pressure transmission component to the corresponding channel, and then start the pressure generators with different ranges in sequence until the touch finger on each pressure generator touches the corresponding range feedback element to complete the distribution of non-integer units of liquid.

[0088] As a further improvement to the above solution, the pressure generator is a piston-type pressure generator. In steps S1 and S2, during pipetting and dispensing:

[0089] S11. When continuous liquid release is required, switch the pressure transmission component to the positive pressure transmission path and inject downward positive pressure into the piston pressure generator. The positive pressure will open the second one-way valve, enter the first air inlet of the second coupling switch along the second flow guide cavity, reach the second transmission port, and enter the integrated medicine tank. The liquid inside will flow out from the liquid outlet of the integrated medicine tank to achieve liquid distribution.

[0090] When the piston is raised, the pressure inside the integrated medicine chamber remains unchanged. Atmosphere enters the first guide chamber through the first air inlet of the first coupling switch, flows through the first one-way valve and enters the piston, in preparation for the next liquid extraction.

[0091] S12. When continuous liquid aspiration is required, switch the pressure transmission component to the negative pressure transmission path to inject downward positive pressure into the piston pressure generator.

[0092] The positive pressure enters the second guide cavity through the second one-way valve, and then flows out from its second interface into the second air inlet of the first coupling switch and is discharged into the atmosphere.

[0093] When the piston rises, the negative pressure draws air from the upper part of the integrated medicine tank through the second air inlet of the second coupling switch into the first guide chamber, and then through the first one-way valve into the piston; the receiving chamber of the liquid outlet generates an equal volume negative pressure, driving external liquid or gas to enter the receiving chamber through the liquid outlet.

[0094] As a further improvement to the above scheme, in steps S1 and S2, during mixing, the second air inlet of the first coupling switch is connected to the atmosphere, while the first air inlet is not connected to the atmosphere.

[0095] Connect the first air inlet of the second coupling switch to the second transmission port, and disconnect the second air inlet from the second transmission port. Then connect the bidirectional coupling switch to the atmosphere. Next, close the liquid outlet of the integrated drug chamber and repeatedly push the reciprocating pressure member to squeeze the balloon, causing the pre-filled reagent in the integrated drug chamber to agitate and mix from side to side.

[0096] Because the present invention adopts the above technical solutions, the beneficial effects of this application are as follows:

[0097] 1. This invention provides a sliding multi-range volume control device, comprising: at least two pressure generators with different ranges, each used to generate a corresponding pressure, and each pressure generator having the same structure; a range switching component having the same number of ranges as the pressure generators, used to switch pressure generators of different ranges to generate a feed amount of a preset volume; a range feedback component having the same number as the pressure generators, with one range feedback component corresponding to each pressure generator; each range feedback component being movably disposed on a shaped support bracket, and its corresponding pressure generator being slidably passing through the range feedback component to limit the extension and retraction of the pressure generator through the range feedback component, thereby realizing the distribution of the preset volume; a shaped support bracket, the range switching component being disposed in the middle of the shaped support bracket, and each pressure generator being spaced apart on the side of the shaped support bracket; and a displacement transmission component having the same number as the pressure generators. One end of the displacement transmission component is connected to the range switching component, passes through the corresponding range feedback component, and is fixedly connected to the corresponding range feedback component. The other end is rotatably connected to the irregular support bracket, so that when the range switching component is switched to the corresponding range, it can drive the corresponding range feedback component to move. In this invention, multiple pressure generators are integrated together through a clever and reasonable layout. Each pressure generator has a different range. Combined with the range switching component, a corresponding range is set for each pressure generator. At its corresponding range, the pressure of a preset volume can be generated by adjusting the range switching component. With this setting, when dispensing non-integer unit liquids, only one pipette corresponding to the sliding multi-range volume control device provided by this invention is needed. There is no need to configure multiple pipettes, thereby reducing experimental interruptions caused by changing pipettes of different specifications and improving experimental efficiency. Specifically, for dispensing 1126.Taking a 5µL liquid as an example, the corresponding sliding multi-range volume control device needs to be equipped with three pressure generators of different specifications: 1000µL, 200µL, and 10µL. These are vertically and parallelly arranged on the side of the irregular support bracket. First, adjust the range switching component to the position corresponding to the 1000µL pressure generator. Then, rotate the range switching component to move its corresponding range feedback element to the position corresponding to the 1000µL volume. Then, start the 1000µL pressure generator to release 1000µL of liquid. Next, adjust the range switching component to the position corresponding to the 200µL pressure generator, and then rotate the range switching component again. The device moves its corresponding range feedback element to the position corresponding to a 120µL volume, then activates the 200µL pressure generator to release 120µL of liquid. Finally, the range switching component is adjusted to the position corresponding to the 10µL pressure generator, and then rotated to move its corresponding range feedback element to the position corresponding to a 6.5µL volume. Then, the 10µL pressure generator is activated to release 6.5µL of liquid, thus achieving high-precision release of non-integer unit liquids. Compared to traditional methods requiring three different sizes of pipettes, the sliding multi-range volume control device provided by this invention saves time and effort and is simple to operate.

[0098] 2. The present invention also provides a multi-range pipette, comprising a housing assembly, a multi-range volume control device, a pressure transmission assembly, and a mixing control assembly disposed within the housing assembly, and an integrated drug reservoir detachably disposed from the housing assembly; the sliding multi-range volume control device includes a range switching assembly and at least two pressure generators for generating release pressure or aspiration pressure; the range switching assembly has the same number of ranges as the number of pressure generators, used to switch to the corresponding range so that the corresponding pressure generator generates pressure corresponding to a preset volume; the pressure outlets of each pressure generator are connected to form a total pressure outlet, and the total pressure outlet is connected to the first transmission port of the pressure transmission assembly; the second transmission port of the pressure transmission assembly is connected to the integrated drug reservoir. The integrated reagent container is connected to a pipette tip; the air outlet of the mixing control component is connected to the integrated reagent container to release mixing pressure to the integrated reagent container, so that the reagent inside reaches a homogeneous state; in this multi-range pipette, because a multi-range volume control device is provided, the range switch component is switched to the corresponding range of each pressure generator, so that the pressure generator generates a preset volume of pressure. By adjusting different ranges in sequence, different preset volumes of pressure can be generated. The preset volume is preset by moving the preset range pointer with a wire instead of the traditional rotary wheel, which is sensitive and quick, so that non-integer units of liquid can be dispensed quickly; it saves operation time and operation costs; at the same time, it can mix in real time, which greatly improves the convenience and efficiency of liquid dispensing and transfer in scientific experiments. Attached Figure Description

[0099] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on the structures shown in these drawings without creative effort.

[0100] Figure 1 This is a three-dimensional schematic diagram of a sliding multi-range volume control device disclosed in this invention.

[0101] Figure 2 This is an exploded schematic diagram of a pressure generator disclosed in this invention;

[0102] Figure 3 This is a three-dimensional schematic diagram of the various range feedback components disclosed in this invention installed on an irregularly shaped support bracket;

[0103] Figure 4 This is a three-dimensional schematic diagram of the irregular support bracket disclosed in this invention;

[0104] Figure 5 This is an exploded view of the gear shift bracket disclosed in this invention;

[0105] Figure 6 An exploded view of the pressure generator bracket disclosed in this invention;

[0106] Figure 7 This is a three-dimensional schematic diagram of the range switching component disclosed in this invention.

[0107] Figure 8 This is a three-dimensional schematic diagram of the gear shift lever disclosed in this invention;

[0108] Figure 9 This is an exploded view of the gear shift lever disclosed in this invention.

[0109] Figure 10 This is an exploded view of the fixed inner ring of each gear position, the inner ring of each guide wheel, and each guide wheel disclosed in this invention.

[0110] Figure 11 This is a three-dimensional schematic diagram of the range feedback device disclosed in this invention. Figure 1 ;

[0111] Figure 12 This is a three-dimensional schematic diagram of the range feedback device disclosed in this invention. Figure 2 ;

[0112] Figure 13 This is a three-dimensional schematic diagram of the range feedback device disclosed in this invention. Figure 3 ;

[0113] Figure 14 This is a three-dimensional schematic diagram of each displacement transmission component disclosed in this invention;

[0114] Figure 15 This is a three-dimensional schematic diagram of the internal parts of the multi-range pipette disclosed in this invention;

[0115] Figure 16 This is a three-dimensional schematic diagram of the connection between the pressure transmission component and the integrated drug tank disclosed in this invention;

[0116] Figure 17 This is a schematic diagram of the pressure transmission component disclosed in this invention;

[0117] Figure 18 This is a three-dimensional schematic diagram showing the connection between the mixing control component and the integrated drug tank disclosed in this invention;

[0118] Figure 19 This is a front view schematic diagram of the multi-range pipette disclosed in this invention;

[0119] Explanation of icon numbers:

[0120] 0. Sliding multi-range volume control device; 1. Pressure generator; 11. Piston cylinder; 12. Piston rod; 13. First reset component; 14. Touch feedback pressure cylinder; 15. Touch finger; 1-1. First pressure generator; 1-2. Second pressure generator; 1-3. Third pressure generator; 2. Range shifting assembly; 21. Knob; 22. Shifting lever; 221. Shifting lever body; 222. Elastic locking protrusion; 223. Limiting spring; 224. Slot; 23. Shifting fixing inner ring; 24. Guide wheel inner ring; 25. Guide wheel; 26. Locking hole;

[0121] 3. Range feedback component; 31. Piston cylinder retaining ring; 32. Support lug; 33. Blind hole; 34. Second reset component; 35. Irregular range pointer; 4. Irregular support bracket; 41. Gear shifting bracket; 411. Vertical support column; 412. Horizontal support column; 413. Sleeve; 414. Guide component; 415. Column; 416. Wire ring; 42. Pressure generator bracket; 421. First frame; 422. Second frame; 423. Piston cylinder rod end fastener; 424. Piston cylinder rodless end fastener; 425. Pulley; 426. Guide rod;

[0122] 43. Measuring scale; 5. Displacement transmission component; 6. Outer shell assembly; 61. Gun body; 62. Drug tank basket; 63. Gun head release assembly; 7. Pressure transmission assembly; 71. First transmission port; 72. Second transmission port; 73. First one-way valve; 74. First flow guide chamber; 741. First interface; 742. Second interface; 743. Third interface; 75. First bidirectional coupling switch; 751. First air inlet; 752. Second air inlet; 753. Air outlet; 76. Second one-way valve; 77. Second flow guide chamber; 78. Second bidirectional coupling switch; 8. Mixing control assembly; 81. Balloon; 82. Reciprocating pressure component; 83. Air guide tube; 84. Bidirectional coupling switch; 9. Integrated drug tank; 10. Total pressure outlet.

[0123] The realization of the objective, functional characteristics and advantages of the present invention will be further explained in conjunction with the embodiments and with reference to the accompanying drawings. Detailed Implementation

[0124] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of them. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0125] It should be noted that all directional indicators (such as up, down, etc.) in the embodiments of the present invention are only used to explain the relative positional relationship and movement of each component in a certain specific posture (as shown in the figure). If the specific posture changes, the directional indicator will also change accordingly.

[0126] Furthermore, in this invention, descriptions involving "first," "second," etc., are for descriptive purposes only and should not be construed as indicating or implying their relative importance or implicitly specifying the number of technical features indicated. Therefore, a feature defined with "first" or "second" may explicitly or implicitly include at least one of that feature.

[0127] Furthermore, the technical solutions of the various embodiments of the present invention can be combined with each other, but only if they are based on the ability of those skilled in the art to implement them. When the combination of technical solutions is contradictory or cannot be implemented, it should be considered that such combination of technical solutions does not exist and is not within the scope of protection claimed by the present invention.

[0128] Example 1:

[0129] Reference Figure 1-14 The present invention provides a sliding multi-range volume control device, comprising:

[0130] At least two pressure generators 1 with different ranges are used to generate corresponding pressures respectively. Each pressure generator 1 has the same structure. In this embodiment, there are three pressure generators 1 with different ranges, namely the first pressure generator 1-1, the second pressure generator 1-2 and the third pressure generator 1-3.

[0131] The range switching component 2 has the same number of ranges as the pressure generator 1, and is used to switch the pressure generator 1 with different ranges to generate a preset volume feed amount. In this embodiment, the range switching component 2 has three different ranges. During operation, the required range is first adjusted, and then the preset volume feed amount is set at the corresponding range.

[0132] The same number of range feedback elements 3 as the pressure generator 1 are provided, with one range feedback element 3 corresponding to each pressure generator 1; in this embodiment, three range feedback elements 3 are provided, which are respectively provided to the first pressure generator 1-1, the second pressure generator 1-2 and the third pressure generator 1-3.

[0133] Each range feedback element 3 is movably mounted on the irregular support bracket 4, and its corresponding pressure generator 1 can slide through the range feedback element 3 to limit the extension and retraction of the pressure generator 1 through the range feedback element 3, thereby realizing the distribution of the preset volume.

[0134] The irregular support bracket 4 has the range switching component 2 vertically arranged in the middle of the irregular support bracket 4; each of the pressure generators 1 is arranged vertically at intervals around the range switching component 2 on the side of the irregular support bracket 4.

[0135] The same number of displacement transmission components 5 as the pressure generator 1, one end of each displacement transmission component 5 is connected to the range switching component 2, passes through the corresponding range feedback component 3, and is fixedly connected to the corresponding range feedback component 3, and the other end is rotatably connected to the irregular support bracket 4, so that when the range switching component 2 is switched to the corresponding range, it can drive the corresponding range feedback component 3 to move.

[0136] In this embodiment, the displacement transmission component 5 is a wire, and the wire is arranged in a closed loop. One end of the closed loop of the wire is wrapped around the range switching component 2.

[0137] The other end of the closed loop of the conductor passes through the corresponding range feedback element 3 and is rotatably connected to the irregular support bracket 4.

[0138] When passing through the corresponding range feedback element 3, one side is fixedly connected to the range feedback element 3, and the other side is slidably connected to the range feedback element 3; with this configuration, when the range gear switching component 2 is rotated, the wire can rotate accordingly, thereby driving the corresponding range feedback element 3 to move linearly, so that the corresponding range feedback element 3 can be in different height positions, thereby realizing the limit adjustment of different volume ranges under the corresponding gear.

[0139] In this invention, multiple pressure generators 1 with different accuracy levels are integrated together through a clever and reasonable layout. Each pressure generator 1 has a different range accuracy, and a range switching component 2 is used to set a corresponding range for each pressure generator 1. At its corresponding range, the pressure of a preset volume can be generated by adjusting the range switching component 2. With this setup, when dispensing non-integer unit liquids, only one pipette corresponding to the sliding multi-range volume control device 0 provided by this invention is needed, eliminating the need for multiple pipettes and reducing the need for replacement. The experimental pauses caused by different sizes of pipettes can be reduced, thus improving experimental efficiency. When this design is used for automated liquid dispensing by a robotic arm, it can also significantly reduce the manufacturing difficulty of the robotic arm, decrease its movement path, and extend its service life. Specifically, taking the dispensing of 1126.5 μL of liquid as an example, the corresponding sliding multi-range volume control device 0 needs to be equipped with three pressure generators 1 of different sizes: 1000 μL, 200 μL, and 10 μL, vertically and parallel to the side of the irregular support bracket 4. First, the range switching component 2 is adjusted to 1000 μL. First, adjust the range switch component 2 to the corresponding setting of the 200µL pressure generator 1, then rotate the range switch component 2 to move the corresponding range feedback element 3 to the position corresponding to the 1000µL volume. Then, start the pressure generator 1 with a range of 1000µL to release 1000µL of liquid. Next, adjust the range switch component 2 to the corresponding setting of the 200µL pressure generator 1, then rotate the range switch component 2 to move the corresponding range feedback element 3 to the position corresponding to the 120µL volume. Then, start the pressure generator 1 with a range of 200µL. The liquid is released, releasing 120uL of liquid. Finally, the range switching component 2 is adjusted to the position corresponding to the 10uL pressure generator 1, and then the range switching component 2 is rotated so that its corresponding range feedback component 3 moves to the position corresponding to the 6.5uL volume. Then, the pressure generator 1 with a range of 10uL is activated to release the liquid, releasing 6.5uL of liquid, thereby completing the release of non-integer unit liquid. Compared with the traditional method that requires three pipettes of different sizes, the sliding multi-range volume control device provided by this invention is time-saving, labor-saving, and easy to operate.

[0140] In a preferred embodiment, the pressure generator 1 includes a piston cylinder 11, a piston rod 12 slidably sleeved in the piston cylinder 11, a first reset member 13 that provides a reset force to the piston rod 12, and a feedback pressure cylinder 14 sleeved on the rod end of the piston rod 12.

[0141] The tactile feedback cylinder 14 is used to transmit tactile force to the piston rod 12, and its tactile finger 15 contacts the corresponding tactile feedback range indicator.

[0142] Specifically, the touch feedback cylinder 14 includes a touch cylinder and a touch finger 15 extending towards the range feedback element 3. The touch cylinder is sleeved on the rod end of the piston rod 12. In use, pressing the touch cylinder moves the piston rod 12 and the touch finger 15 together until the touch finger 15 touches the range feedback element 3, thus completing the release or absorption of the preset volume. With this structure, it is only necessary to adjust it to the set position. During operation, pressing the touch cylinder can realize the release or absorption of a quantitative volume. After the release or absorption is completed, the piston rod 12 is reset under the action of the first reset element 13 for the next press, and so on, to realize continuous release or absorption.

[0143] In this embodiment, the first reset is a compression spring sleeved on the outside of the piston rod 12.

[0144] In a preferred embodiment, the range shifting assembly 2 includes a knob 21, a shifting lever 22 fixedly connected to the knob 21 at one end, shift fixing inner rings 23 and guide wheel inner rings 24 alternately sleeved on the outer wall of the shifting lever 22. Specifically, in this embodiment, four shift fixing inner rings 23 with the same inner and outer diameters are provided, and the four shift fixing inner rings 23 are coaxially spaced apart, with gaps between adjacent shift fixing inner rings 23; three guide wheel 25 inner rings 24 with the same inner and outer diameters are also provided, and the three guide wheel 25 inner rings 24 are correspondingly arranged in the gaps and coaxially arranged with the shift fixing inner rings 23, forming a tube sleeve; and the shifting lever 22 is rotatably disposed in the tube sleeve and can drive the guide wheel 25 inner rings 24 to rotate;

[0145] Each pressure generator 1 is provided with a corresponding inner ring 24 of the guide wheel 25, and each inner ring 24 of the guide wheel 25 corresponds to a gear position;

[0146] Each of the guide wheels 25 is further sleeved on the outer side of the inner ring 24. The inner ring 24 of the guide wheel 25 and the middle part of the guide wheel 25 are respectively provided with locking holes 26 perpendicular to their axes. The gear shift lever 22 includes a shift lever body 221 and an elastic locking protrusion 222 provided on the side of the shift lever body 221. The elastic locking protrusion 222 is operably locked in the locking hole 26 of the corresponding gear.

[0147] In this embodiment, the inner ring 24 of the guide wheel 25 and the locking holes 26 on the guide wheel 25 are arranged in a one-to-one correspondence so that the locking protrusion on the gear shift lever 22 can be smoothly locked in the corresponding locking hole 26 so as to drive the inner ring 24 of the guide wheel 25 and the guide wheel 25 to rotate by rotating the gear shift lever 22;

[0148] The displacement transmission element 5, that is, one end of the wire is wound around the wire wheel 25, thereby driving the wire to generate displacement.

[0149] In a preferred embodiment, the switching lever body 221 is a cylindrical rod with symmetrical slots 224 on both sides. Each slot 224 contains a limiting spring 223, and a spring is provided between the two limiting springs 223. Each limiting spring 223 has an elastic protrusion 222. During operation, by applying force to the outer sides of the two limiting springs 223, the springs are compressed, causing the elastic protrusion 222 to retract and disengage from the corresponding slot 26. When the gear switching lever 22 is pulled or pushed until a preset gear is reached, the force applied to the outer sides of the two limiting springs 223 is released, and the elastic protrusion 222 engages in the slot 26 of the corresponding gear.

[0150] One end of the gear shift lever 22 is fixedly connected to the knob 21 by a fastener.

[0151] In a preferred embodiment, the irregular support bracket 4 includes a gear shift bracket 41, a pressure generator bracket 42, and a range scale 43;

[0152] The gear shift bracket 41 is vertically mounted on the top of the pressure generator bracket 42, and the range scale 43 is vertically fixed to the side of the pressure generator bracket 42 to indicate the moving position of the tactile feedback range indicator; the irregular support bracket 4 provides support, limit, coupling and displacement indication for the linkage and movement of each pressure generator 1, range shift component 2, displacement transmission component 5 and range feedback component 3.

[0153] Specifically, the pressure generator bracket 42 includes a first frame 421 and a second frame 422 arranged parallel to each other from top to bottom. The outer wall of the first frame 421 extends outward along its circumference with piston cylinder rod end fasteners 423 corresponding to the number of pressure generators 1. In this embodiment, three piston cylinder rod end fasteners 423 are provided, respectively located at three different edges of the first frame 421.

[0154] The outer wall of the second frame 422 extends outward along its circumference with piston cylinder rodless end fasteners 424 corresponding to the number of pressure generators 1; in this embodiment, three piston cylinder rodless end fasteners 424 are provided, respectively located at three different edges of the second frame 422; the rod end of the piston cylinder 11 is provided in one-to-one correspondence with the piston cylinder rodless end fasteners 424, and a corresponding set is used to fix and support one pressure generator 1;

[0155] The inner wall of the second frame 422 is provided with pulleys 425 corresponding to the number of pressure generators 1, so that the other end of the displacement transmission member 5 can be rotatably connected; specifically, the other end of the wire closed loop passes through the corresponding range feedback member 3 and is rotatably connected to the pulleys 425 on the inner wall of the second frame 422.

[0156] Furthermore, a guide rod 426 corresponding to the number of pressure generators 1 is provided between the first frame 421 and the second frame 422, and each range feedback element 3 is slidably disposed on the corresponding guide rod 426; the arrangement of the guide rod 426 ensures that the corresponding range feedback element 3 can move smoothly in a straight line.

[0157] In a preferred embodiment, the gear shift bracket 41 includes a vertical support column 411 and a plurality of horizontal support columns 412 cantilevered on one side of the vertical support column 411.

[0158] The horizontal support columns 412 are fixedly installed at equal intervals from top to bottom on one side of the vertical support columns 411;

[0159] Each of the horizontal support columns 412 has a sleeve 413 at its cantilever end, and each sleeve 413 is coaxially arranged. The range switching component 2 is rotatably arranged in each coaxially arranged sleeve 413.

[0160] The cantilever end of the horizontal support column 412 at the lowest position is provided with a plurality of guide members 414 along the circumference of its corresponding sleeve 413 for supporting the displacement transmission member 5. Specifically, in this embodiment, there are 3 guide members 414, which are respectively used to support the corresponding displacement transmission member 5.

[0161] The guide member 414 includes a column 415 and a guide ring 416 disposed on the side of the column 415. The guide ring is provided with a through hole through which the displacement transmission member 5 slides.

[0162] The column 415 is welded to the end of the horizontal support column 412 at the lowest position;

[0163] The guide 414 is designed to prevent interference between the various displacement transmission components 5, and to provide guidance for the corresponding wires when they need to move.

[0164] As a preferred embodiment, see Figure 11-13 The range feedback component 3 includes a piston cylinder fixing ring 31 through which the piston cylinder 11 passes. The outer walls of the piston cylinder fixing ring 31 extend outward from opposite sides to form lugs 32. The lugs 32 are provided with blind holes 33 along their thickness direction. A second reset component 34 is provided in the blind hole 33 to provide reset force for the touch feedback pressure cylinder 14.

[0165] The outer wall of the piston cylinder retaining ring 31 is also provided with an irregular range pointer 35, which is used to indicate the preset volume feed amount under the current gear; the needle of each irregular range pointer 35 points to the range scale 43, and in order to enable each irregular range pointer 35 to point to the range scale 43, the irregular range pointer 35 corresponding to each pressure generator 1 has a different shape.

[0166] The root of the irregular range pointer 35 is provided with a fixing hole for fixing one side of the displacement transmission member 5, and a through hole for the other side of the displacement transmission member 5 to slide through.

[0167] It should be noted that when the displacement transmission component 5 is fixed through the fixing hole, other fasteners, such as expansion sleeves, are also needed to ensure that one side of the displacement transmission dummy is securely connected to the corresponding range feedback component 3.

[0168] Example 2:

[0169] In a second aspect, the present invention also provides a control method for the above-mentioned sliding multi-range volume control device 0, the steps of which include:

[0170] S1: First, pull or push the range switching component 2 to make it position corresponding to the first preset volume.

[0171] S2: Rotate the range switching component 2 again to drive the displacement transmission component 5 connected to it to rotate, thereby driving the range feedback component 3 fixedly connected to the displacement transmission component 5 to move linearly until the range feedback component 3 moves to the position corresponding to the first preset volume.

[0172] S3: Pull or push the range switching component 2 again to make it position corresponding to the second preset volume; repeat step S2 to move the corresponding range feedback component 3 to the position corresponding to the second preset volume, and so on, until the corresponding range feedback component 3 of the corresponding position moves to the corresponding preset volume.

[0173] S4: Then, the pressure generators 1 of the corresponding ranges are started in sequence until the contact finger 15 on each pressure generator 1 touches the corresponding range feedback element 3 to realize the distribution of non-integer units of liquid.

[0174] With this setup, before dispensing, the range switching component 2 is switched to the range corresponding to the preset volume, and then the range feedback component 3 corresponding to each range is adjusted to the corresponding preset volume position. Then, the pressure generator 1 of the corresponding range is activated in sequence to achieve the dispensing of non-integer units of liquid. By simply switching to different ranges and adjusting them to the positions corresponding to the preset volumes, different non-integer volumes can be combined. Compared with traditional liquid dispensing methods, there is no need to prepare multiple pipettes of different specifications, and there is no need to change or stop in the middle. This simplifies the experimental process and improves experimental efficiency. When it is mounted on an automated robotic arm for liquid dispensing, it can also reduce the design difficulty of the robotic arm, reduce the movement path of the robotic arm, and extend the service life of the robotic arm.

[0175] In some embodiments, the control method can also be implemented through the following steps, as detailed below:

[0176] S1': First, pull or push the range switching component 2 to make it position corresponding to the first preset volume;

[0177] S2': Rotate the range switching component 2 again to drive the displacement transmission component 5 connected to it to rotate, so as to drive the range feedback component 3 fixedly connected to the displacement transmission component to move linearly until the range feedback component 3 moves to the position corresponding to the first preset volume.

[0178] S3': Then start the pressure generator 1 of the corresponding range until the contact finger 15 on the pressure generator 1 touches the corresponding range feedback element 3, that is, the range of the first preset volume is reached, and then the distribution is carried out through the distribution structure.

[0179] S4': Pull or push the range switching component 2 again to make it position corresponding to the second preset volume; repeat step S2' to move the corresponding range feedback component 3 to the position corresponding to the second preset volume, repeat step S3', and so on to achieve the distribution of non-integer unit liquid;

[0180] While this setup is more cumbersome than the previous method of first switching the range switching component 2 to the range corresponding to the preset volume, then uniformly adjusting the range feedback component 3 corresponding to each range to the corresponding preset volume position, and then sequentially activating the pressure generator 1 of the corresponding range to distribute non-integer units of liquid, it simplifies the experimental process and improves experimental efficiency compared to the traditional liquid distribution method. It eliminates the need to prepare multiple pipettes of different specifications and eliminates the need for replacement or stopping in the middle. When it is mounted on an automated robotic arm for liquid distribution, it can also reduce the design difficulty of the robotic arm, reduce the movement path of the robotic arm, and extend the service life of the robotic arm.

[0181] Example 3:

[0182] Thirdly, see Figure 1-19 The present invention also provides a multi-range pipette, including a housing assembly 6, a sliding multi-range volume control device 0, a pressure transmission assembly 7 and a mixing control assembly 8 disposed in the housing assembly 6, and an integrated medicine tank 9 that is detachably disposed from the housing assembly 6.

[0183] The sliding multi-range volume control device 0 includes a range switching component 2 and at least two pressure generators 1 for generating release pressure or suction pressure. Each pressure generator 1 has the same structure. In this embodiment, there are three pressure generators 1 with different ranges, namely the first pressure generator 1-1, the second pressure generator 1-2 and the third pressure generator 1-3.

[0184] The range switching component 2 has the same number of ranges as the pressure generator 1, and is used to switch to the corresponding range so that the corresponding pressure generator 1 generates the corresponding preset volume of pressure. In this embodiment, the range switching component 2 has three different ranges. During operation, the required range is first adjusted, and then the preset volume of feed is set at the corresponding range.

[0185] The pressure outlets of each pressure generator 1 are connected to form a total pressure outlet 10, and the total pressure outlet 10 is connected to the first transmission port 71 of the pressure transmission assembly 7.

[0186] The second transmission port 72 of the pressure transmission component 7 is connected to the integrated drug tank 9, and the integrated drug tank 9 is connected to a pipette tip.

[0187] The air outlet 753 of the mixing control component 8 is connected to the integrated drug container 9 and is used to release mixing pressure to the integrated drug container 9 so that the reagent inside reaches a uniform state.

[0188] In this multi-range pipette, a multi-range volume control device is provided. By switching the range level switching component 2 to the level corresponding to each pressure generator 1, the pressure generator 1 generates a preset volume of pressure. By adjusting different levels in sequence, different preset volumes of pressure can be generated, thereby enabling the rapid distribution of non-integer units of liquid. This saves operation time and operating costs. At the same time, it can also mix in real time, greatly improving the convenience and efficiency of liquid distribution and transfer in scientific experiments. When it is mounted on an automated robotic arm for liquid distribution, it can also reduce the design difficulty of the robotic arm, reduce the movement path of the robotic arm, and extend the service life of the robotic arm.

[0189] As a preferred embodiment, see Figures 1-14 The multi-range volume control device further includes:

[0190] The same number of range feedback elements 3 as the pressure generator 1 are provided, with one range feedback element 3 corresponding to each pressure generator 1; in this embodiment, three range feedback elements 3 are provided, which are respectively provided to the first pressure generator 1-1, the second pressure generator 1-2 and the third pressure generator 1-3.

[0191] Each range feedback element 3 is movably mounted on the irregular support bracket 4, and its corresponding pressure generator 1 can slide through the range feedback element 3 to limit the extension and retraction of the pressure generator 1 through the range feedback element 3, thereby realizing the distribution of the preset volume.

[0192] The irregular support bracket 4 has the range switching component 2 vertically arranged in the middle of the irregular support bracket 4; each of the pressure generators 1 is arranged vertically at intervals around the range switching component 2 on the side of the irregular support bracket 4.

[0193] The same number of displacement transmission components 5 as the pressure generator 1, one end of each displacement transmission component 5 is connected to the range switching component 2, passes through the corresponding range feedback component 3, and is fixedly connected to the corresponding range feedback component 3, and the other end is rotatably connected to the irregular support bracket 4, so that when the range switching component 2 is switched to the corresponding range, it can drive the corresponding range feedback component 3 to move.

[0194] In this embodiment, the displacement transmission component 5 is a wire, and the wire is arranged in a closed loop. One end of the closed loop of the wire is wrapped around the range switching component 2.

[0195] The other end of the closed loop of the conductor passes through the corresponding range feedback element 3 and is rotatably connected to the irregular support bracket 4.

[0196] When passing through the corresponding range feedback element 3, one side is fixedly connected to the range feedback element 3, and the other side is slidably connected to the range feedback element 3; with this configuration, when the range gear switching component 2 is rotated, the wire can rotate accordingly, thereby driving the corresponding range feedback element 3 to move linearly, so that the corresponding range feedback element 3 can be in different height positions, thereby realizing the limit adjustment of different volume ranges under the corresponding gear.

[0197] In a preferred embodiment, the pressure generator 1 includes a piston cylinder 11, a piston rod 12 slidably sleeved in the piston cylinder 11, a first reset member 13 that provides a reset force to the piston rod 12, and a feedback pressure cylinder 14 sleeved on the rod end of the piston rod 12.

[0198] The tactile feedback cylinder 14 is used to transmit tactile force to the piston rod 12, and its tactile finger 15 contacts the corresponding tactile feedback range indicator.

[0199] Specifically, the touch feedback cylinder 14 includes a touch cylinder and a touch finger 15 extending towards the range feedback element 3. The touch cylinder is sleeved on the rod end of the piston rod 12. In use, pressing the touch cylinder moves the piston rod 12 and the touch finger 15 together until the touch finger 15 touches the range feedback element 3, thus completing the release or absorption of the preset volume. With this structure, it is only necessary to adjust it to the set position. During operation, pressing the touch cylinder can realize the release or absorption of a quantitative volume. After the release or absorption is completed, the piston rod 12 is reset under the action of the first reset element 13 for the next press, and so on, to realize continuous release or absorption.

[0200] In this embodiment, the first reset is a compression spring sleeved on the outside of the piston rod 12.

[0201] In a preferred embodiment, the range shifting assembly 2 includes a knob 21, a shifting lever 22 fixedly connected to the knob 21 at one end, shift fixing inner rings 23 and guide wheel inner rings 24 alternately sleeved on the outer wall of the shifting lever 22. Specifically, in this embodiment, four shift fixing inner rings 23 with the same inner and outer diameters are provided, and the four shift fixing inner rings 23 are coaxially spaced apart, with gaps between adjacent shift fixing inner rings 23; three guide wheel 25 inner rings 24 with the same inner and outer diameters are also provided, and the three guide wheel 25 inner rings 24 are correspondingly arranged in the gaps and coaxially arranged with the shift fixing inner rings 23, forming a tube sleeve; and the shifting lever 22 is rotatably disposed in the tube sleeve and can drive the guide wheel 25 inner rings 24 to rotate;

[0202] Each pressure generator 1 is provided with a corresponding inner ring 24 of the guide wheel 25, and each inner ring 24 of the guide wheel 25 corresponds to a gear position;

[0203] Each of the guide wheels 25 is further sleeved on the outer side of the inner ring 24. The inner ring 24 of the guide wheel 25 and the middle part of the guide wheel 25 are respectively provided with locking holes 26 perpendicular to their axes. The gear shift lever 22 includes a shift lever body 221 and an elastic locking protrusion 222 provided on the side of the shift lever body 221. The elastic locking protrusion 222 is operably locked in the locking hole 26 of the corresponding gear.

[0204] In this embodiment, the inner ring 24 of the guide wheel 25 and the locking holes 26 on the guide wheel 25 are arranged in a one-to-one correspondence so that the locking protrusion on the gear shift lever 22 can be smoothly locked in the corresponding locking hole 26 so as to drive the inner ring 24 of the guide wheel 25 and the guide wheel 25 to rotate by rotating the gear shift lever 22;

[0205] The displacement transmission element 5, that is, one end of the wire is wound around the wire wheel 25, thereby driving the wire to generate displacement.

[0206] In a preferred embodiment, the switching lever body 221 is a cylindrical rod with symmetrical slots 224 on both sides. Each slot 224 contains a limiting spring 223, and a spring is provided between the two limiting springs 223. Each limiting spring 223 has an elastic protrusion 222. During operation, by applying force to the outer sides of the two limiting springs 223, the springs are compressed, causing the elastic protrusion 222 to retract and disengage from the corresponding slot 26. When the gear switching lever 22 is pulled or pushed until a preset gear is reached, the force applied to the outer sides of the two limiting springs 223 is released, and the elastic protrusion 222 engages in the slot 26 of the corresponding gear.

[0207] One end of the gear shift lever 22 is fixedly connected to the knob 21 by a fastener.

[0208] In a preferred embodiment, the irregular support bracket 4 includes a gear shift bracket 41, a pressure generator bracket 42, and a range scale 43;

[0209] The gear shift bracket 41 is vertically mounted on the top of the pressure generator bracket 42, and the range scale 43 is vertically fixed to the side of the pressure generator bracket 42 to indicate the moving position of the tactile feedback range indicator; the irregular support bracket 4 provides support, limit, coupling and displacement indication for the linkage and movement of each pressure generator 1, range shift component 2, displacement transmission component 5 and range feedback component 3.

[0210] Specifically, the pressure generator bracket 42 includes a first frame 421 and a second frame 422 arranged parallel to each other from top to bottom. The outer wall of the first frame 421 extends outward along its circumference with piston cylinder rod end fasteners 423 corresponding to the number of pressure generators 1. In this embodiment, three piston cylinder rod end fasteners 423 are provided, respectively located at three different edges of the first frame 421.

[0211] The outer wall of the second frame 422 extends outward along its circumference with piston cylinder rodless end fasteners 424 corresponding to the number of pressure generators 1; in this embodiment, three piston cylinder rodless end fasteners 424 are provided, respectively located at three different edges of the second frame 422; the rod end of the piston cylinder 11 is provided in one-to-one correspondence with the piston cylinder rodless end fasteners 424, and a corresponding set is used to fix and support one pressure generator 1;

[0212] The inner wall of the second frame 422 is provided with pulleys 425 corresponding to the number of pressure generators 1, so that the other end of the displacement transmission member 5 can be rotatably connected; specifically, the other end of the wire closed loop passes through the corresponding range feedback member 3 and is rotatably connected to the pulleys 425 on the inner wall of the second frame 422.

[0213] Furthermore, a guide rod 426 corresponding to the number of pressure generators 1 is provided between the first frame 421 and the second frame 422, and each range feedback element 3 is slidably disposed on the corresponding guide rod 426; the arrangement of the guide rod 426 ensures that the corresponding range feedback element 3 can move smoothly in a straight line.

[0214] In a preferred embodiment, the gear shift bracket 41 includes a vertical support column 411 and a plurality of horizontal support columns 412 cantilevered on one side of the vertical support column 411.

[0215] The horizontal support columns 412 are fixedly installed at equal intervals from top to bottom on one side of the vertical support columns 411;

[0216] Each of the horizontal support columns 412 has a sleeve 413 at its cantilever end, and each sleeve 413 is coaxially arranged. The range switching component 2 is rotatably arranged in each coaxially arranged sleeve 413.

[0217] The cantilever end of the horizontal support column 412 at the lowest position is provided with a plurality of guide members 414 along the circumference of its corresponding sleeve 413 for supporting the displacement transmission member 5. Specifically, in this embodiment, there are 3 guide members 414, which are respectively used to support the corresponding displacement transmission member 5.

[0218] The guide member 414 includes a column 415 and a guide ring 416 disposed on the side of the column 415. The guide ring is provided with a through hole through which the displacement transmission member 5 slides.

[0219] The column 415 is welded to the end of the horizontal support column 412 at the lowest position;

[0220] The guide 414 is designed to prevent interference between the various displacement transmission components 5, and to provide guidance for the corresponding wires when they need to move.

[0221] As a preferred embodiment, see Figure 11-13 The range feedback component 3 includes a piston cylinder fixing ring 31 through which the piston cylinder 11 passes. The outer walls of the piston cylinder fixing ring 31 extend outward from opposite sides to form lugs 32. The lugs 32 are provided with blind holes 33 along their thickness direction. A second reset component 34 is provided in the blind hole 33 to provide reset force for the touch feedback pressure cylinder 14.

[0222] The outer wall of the piston cylinder retaining ring 31 is also provided with an irregular range pointer 35, which is used to indicate the preset volume feed amount under the current gear; the needle of each irregular range pointer 35 points to the range scale 43, and in order to enable each irregular range pointer 35 to point to the range scale 43, the irregular range pointer 35 corresponding to each pressure generator 1 has a different shape.

[0223] The root of the irregular range pointer 35 is provided with a fixing hole for fixing one side of the displacement transmission member 5, and a through hole for the other side of the displacement transmission member 5 to slide through.

[0224] It should be noted that when the displacement transmission component 5 is fixed through the fixing hole, other fasteners, such as expansion sleeves, are also needed to ensure that one side of the displacement transmission dummy is securely connected to the corresponding range feedback component 3.

[0225] In a preferred embodiment, the pressure transmission component 7 includes a positive pressure transmission channel and a negative pressure transmission channel that are coupled together, and can operably transmit release pressure or absorb pressure;

[0226] The negative pressure transmission channel includes a first one-way valve 73, a first flow guide cavity 74, and a first bidirectional coupling switch 75 connected in sequence. One end of the first one-way valve 73 is unidirectionally connected to the first interface 741 of the first flow guide cavity 74, and the second interface 742 of the first flow guide cavity 74 is connected to the first air inlet 751 of the first bidirectional coupling switch 75. The first bidirectional coupling switch 75 is also provided with two air outlets 753 for communicating with the atmosphere.

[0227] The positive pressure transmission channel includes a second one-way valve 76, a second flow guide cavity 77, and a second bidirectional coupling switch 78 connected in sequence. One end of the second one-way valve 76 is unidirectionally connected to the first interface 741 of the second flow guide cavity 77, and the second interface 742 of the second flow guide cavity 77 is connected to the second air inlet 752 of the first bidirectional coupling switch 75. The third interface 743 of the second flow guide cavity 77 is connected to the first air inlet 751 of the second bidirectional coupling switch 78.

[0228] The third interface 743 of the first flow guide cavity 74 is connected to the second air inlet 752 of the second bidirectional coupling switch 78;

[0229] The first one-way valve 73 and the second one-way valve 76 have opposite conduction directions, and the other end of the first one-way valve 73 and the other end of the second one-way valve 76 are connected to form the first transmission port 71.

[0230] The two outlets 753 of the second bidirectional coupling switch 78 are connected to form the second transmission port 72;

[0231] Specifically, both the first bidirectional coupling switch 75 and the second bidirectional coupling switch 78 have two working positions. When continuous equal release is required, both the first bidirectional coupling switch 75 and the second bidirectional coupling switch 78 are switched to the first working position. The second one-way valve 76 is connected to the second guide cavity 77 along the pressure outlet of the pressure generating device. The third interface 743 of the second guide cavity 77 is connected to the first air inlet 751 of the second bidirectional coupling switch 78, and the third interface 743 of the first guide cavity 74 is disconnected from the second air inlet 752 of the second bidirectional coupling switch 78. Because the first one-way valve 76... The conduction direction of valve 3 is opposite to that of the second one-way valve 76. At this time, when the pressure generating device is pressed, the pressure generated can only be transmitted to the integrated medicine tank 9 through the second one-way valve 76 to achieve liquid distribution. During the piston rod 12 reset process, due to the one-way conduction setting of the second one-way valve 76, the negative pressure cannot be transmitted to the integrated medicine tank 9. Since the first bidirectional coupling switch 75 is in the first working position, the second interface 742 of the first guide cavity 74 is connected to the atmosphere, and then transmitted to the pressure port of the pressure generating device through the first one-way valve 73. This process is repeated to achieve continuous and equal release of liquid.

[0232] When continuous equal-division release is required, both the first bidirectional coupling switch 75 and the second bidirectional coupling switch 78 are switched to the second working position. When the pressure generating device is pressed, the generated positive pressure is connected to the atmosphere sequentially through the second one-way valve 76, the second interface 742 of the second flow guide chamber 77, and the second air inlet 752 of the first bidirectional coupling switch 75. That is, the generated positive pressure is released into the air through the first bidirectional coupling switch 75. During the rebound reset process of the pressure generating device, the negative pressure attracts the air in the upper part of the integrated medicine tank 9 through the second air inlet 752 of the second coupling switch, into the flow guide chamber, and then through the first one-way valve 73 into the piston. The receiving cavity of the liquid outlet generates an equal-volume negative pressure, thereby drawing the liquid in the container into the empty integrated medicine tank 9. This process is repeated to achieve continuous equal-division release and absorption.

[0233] The pressure transmission component 7, through the coupled positive pressure transmission channel and negative pressure transmission channel, enables it to transmit both positive and negative pressure. Specifically, by simply operating the first bidirectional coupling switch 75 and the second bidirectional coupling switch 78 to connect the corresponding channels, and combined with the reasonable arrangement of the one-way valves, it can effectively and continuously transmit positive or negative pressure. The structure is simple and reliable, providing a favorable foundation for the continuous dispensing device to achieve both continuous liquid release and continuous liquid absorption.

[0234] In a preferred embodiment, the mixing control component 8 includes a balloon 81 and a reciprocating pressing member 82 for contacting the balloon 81. One end of the balloon 81 is connected to an air guide tube 83, which extends into the integrated drug compartment 9. The other end of the balloon 81 is connected to a bidirectional coupling switch 84, which also has an air inlet.

[0235] The reciprocating pressure member 82 includes a bracket for fixing the balloon 81 and a button on the bracket. By squeezing the button, the balloon 81 is squeezed, and the pressure generated by the balloon 81 is introduced into the integrated drug chamber 9, thereby mixing the reagents inside.

[0236] In some preferred embodiments, the integrated drug tank 9 is also provided with a flow-turbing element. The combination of mixing pressure and the flow-turbing element ensures that the reagents inside are fully mixed. Since the mixing control component 8 is directly connected to the integrated drug tank 9, real-time mixing can be achieved. During the liquid separation process, there is no need to stop and change to different sizes of pipettes for blowing, thereby simplifying the operation process and improving experimental efficiency.

[0237] As a further improvement to the above solution, the outer casing assembly 6 includes a gun body 61 for easy gripping, a medicine compartment basket 62 secured to the bottom of the gun body 61, and a pipette tip release assembly 63 disposed on the outer wall of the gun body 61.

[0238] The pipette tip release assembly 63 is used to disassemble the pipette tip mounted on the integrated medicine tank 9;

[0239] The pipette tip release assembly 63 is used to disassemble the pipette tip mounted on the integrated medicine tank 9;

[0240] Specifically, the medicine storage basket 62 includes a frame that supports the integrated medicine storage 9, and the frame is composed of several horizontal ribs and several vertical ribs to form a semi-enclosed structure that matches the shape of the integrated medicine storage 9. The top of the frame is provided with several locking rods, and correspondingly, the gun body 61 is provided with locking holes 26 that match the locking rods.

[0241] The pipette tip release assembly 63 includes a pusher and a pull rod connected to the pusher. The pull rod is slidably fitted against the outer wall of the pipette body 61. The pusher is located at the bottom of the medicine container basket 62 and is used to push the connector of the pipette tip. In use, the pull rod is pushed down so that the pusher touches the connector of the pipette tip until the pipette tip falls off from the integrated medicine container 9.

[0242] Example 4:

[0243] Fourthly, the present invention also provides a pipetting method for the above-mentioned multi-range pipette, the steps of which include:

[0244] S1: First, adjust the range switching component 2 to the range corresponding to the preset volume, and then uniformly adjust the range feedback component 3 corresponding to each range to the corresponding preset volume position.

[0245] S2: Then switch the pressure transmission component 7 to the corresponding channel, and then start the pressure generators 1 with different ranges in sequence until the contact finger 15 on each pressure generator 1 touches the corresponding range feedback element 3 to complete the rapid and high-precision distribution of non-integer unit liquid.

[0246] With this setup, you can combine different non-integer volumes simply by switching to different gears and adjusting them to the positions corresponding to the preset volumes. Compared to traditional liquid dispensing methods, there is no need to prepare multiple pipettes of different sizes, and there is no need to change or stop them in the middle. This simplifies the experimental process and improves experimental efficiency. When it is mounted on an automated robotic arm for liquid dispensing, it can also reduce the design difficulty of the robotic arm, reduce the movement path of the robotic arm, and extend the service life of the robotic arm.

[0247] In some embodiments, the pipetting method can also be implemented through the following steps, as detailed below:

[0248] S1': Adjust the range switching component 2 of the multi-range volume control device to the range corresponding to the first preset volume, then adjust the range switching component 2 to move the corresponding range feedback component 3 to the position corresponding to the first preset volume, start the pressure generator 1 with the first range, until the contact finger 15 on the pressure generator 1 touches the corresponding range feedback component 3, that is, the range of the first preset volume is reached, then switch the pressure transmission component 7 to the corresponding channel to complete the distribution of the first preset volume;

[0249] S2': Adjust the range switching component 2 of the multi-range volume control device to the range corresponding to the second preset volume, and then adjust the range switching component 2 to move the corresponding range feedback element 3 to the position corresponding to the second preset volume. Start the pressure generator 1 with the second range until the contact finger 15 on the pressure generator 1 touches the corresponding range feedback element 3, that is, the range of the second preset volume is reached. Then switch the pressure transmission component 7 to the corresponding channel to complete the distribution of the second preset volume. Repeat this process to complete the rapid and high-precision distribution of non-integer unit liquids.

[0250] While this setup is more cumbersome than the previous method of first switching the range switching component 2 to the range corresponding to the preset volume, then uniformly adjusting the range feedback component 3 corresponding to each range to the corresponding preset volume position, and then sequentially activating the pressure generator 1 of the corresponding range to distribute non-integer units of liquid, it simplifies the experimental process and improves experimental efficiency compared to the traditional liquid distribution method. It eliminates the need to prepare multiple pipettes of different specifications and eliminates the need for replacement or stopping in the middle. When it is mounted on an automated robotic arm for liquid distribution, it can also reduce the design difficulty of the robotic arm, reduce the movement path of the robotic arm, and extend the service life of the robotic arm.

[0251] In a preferred embodiment, the pressure generator 1 is a piston-type pressure generator 1. In steps S1 and S2, during pipetting and dispensing:

[0252] S11. When continuous liquid release is required, the pressure transmission component 7 is switched to the positive pressure transmission path, and downward positive pressure is injected into the piston pressure generator 1. The positive pressure opens the second one-way valve 76, enters the first air inlet 751 of the second coupling switch along the second flow guide cavity 77, reaches the second transmission port 72, and enters the integrated medicine tank 9, so that the liquid inside flows out from the liquid outlet of the integrated medicine tank 9 to realize liquid distribution.

[0253] When the piston is lifted, the pressure inside the integrated medicine tank 9 remains unchanged. Atmosphere enters the first guide chamber 74 through the first air inlet 751 of the first coupling switch, flows through the first one-way valve 73 and enters the piston, in preparation for the next liquid extraction.

[0254] S12. When continuous liquid aspiration is required, switch the pressure transmission component 7 to the negative pressure transmission path and inject downward positive pressure into the piston pressure generator 1.

[0255] The positive pressure enters the second guide chamber 77 through the second one-way valve 76, and then flows out from its second interface 742 into the second air inlet 752 of the first coupling switch and is discharged into the atmosphere.

[0256] When the piston is lifted, the negative pressure draws the air from the upper part of the integrated medicine tank 9 through the second air inlet 752 of the second coupling switch into the first guide chamber, and then through the first one-way valve 73 into the piston; the receiving chamber of the liquid outlet generates an equal volume negative pressure, driving external liquid or gas to enter the receiving chamber through the liquid outlet.

[0257] With this setup, for experiments requiring liquid replacement midway, only the integrated reagent tank 9 needs to be replaced and the corresponding pressure transmission channel switched. Compared to traditional pipettes that can only release or aspirate liquid, there is no need to replace the pipette midway, thus simplifying the experimental procedure and improving experimental efficiency. Furthermore, when aspirating liquid, because there is an empty integrated reagent tank 9, each aspirated liquid is stored in the integrated reagent tank 9. Unlike traditional pipettes, which require discarding the old liquid into a waste container after each aspiration before proceeding with the next aspiration, this setup further improves experimental efficiency.

[0258] In a preferred embodiment, during mixing in steps S1 and S2, the second air inlet 752 of the first coupling switch is connected to the atmosphere, while the first air inlet 751 is not connected to the atmosphere.

[0259] Connect the first air inlet 751 of the second coupling switch to the second transmission port 72, and disconnect the second air inlet 752 from the second transmission port 72. Then connect the bidirectional coupling switch 84 to the atmosphere. Then close the liquid outlet of the integrated drug tank 9 and repeatedly push the reciprocating pressure member 82 to squeeze the balloon 81, causing the pre-filled reagent in the integrated drug tank 9 to agitate and mix from side to side.

[0260] With this setup, by operating the first bidirectional coupling switch 75 and the second bidirectional coupling switch 78 to switch them to the corresponding communication channels and controlling the closed state of the bidirectional coupling switch 84, continuous liquid release or continuous liquid absorption, as well as real-time mixing, can be achieved. This solves the functional compatibility problem in fluid distribution control, eliminates the need for continuous operation interruption, and greatly reduces the redundancy of fluid distribution operation time and steps.

[0261] The above are merely preferred embodiments of the present invention and do not limit the patent scope of the present invention. All equivalent structural transformations made using the contents of the present invention's specification and drawings under the inventive concept of the present invention, or direct / indirect applications in other related technical fields, are included within the patent protection scope of the present invention.

Claims

1. A sliding multi-range volume control device, characterized in that, include: At least two pressure generators with different ranges are used to generate corresponding pressures, and each pressure generator has the same structure. The range switching component has the same number of ranges as the pressure generators, and is used to switch pressure generators of different ranges to generate a feed amount of a preset volume. The number of range feedback elements is the same as the number of pressure generators, with one range feedback element corresponding to each pressure generator; An irregularly shaped support bracket, wherein the range switching component is disposed in the middle of the irregularly shaped support bracket, and each of the pressure generators is disposed at intervals on the side of the irregularly shaped support bracket; Each range feedback element is movably mounted on the irregular support bracket, and its corresponding pressure generator can slide through the range feedback element to limit the extension and retraction of the pressure generator through the range feedback element, thereby realizing the distribution of the preset volume. The displacement transmitters are the same number as the pressure generators. One end of each displacement transmitter is connected to the range switching component, passes through the corresponding range feedback component, and is fixedly connected to the corresponding range feedback component. The other end is rotatably connected to the irregular support bracket, so that when the range switching component is switched to the corresponding range, it can drive the corresponding range feedback component to move.

2. The sliding multi-range volume control device according to claim 1, characterized in that, The pressure generator includes a piston cylinder, a piston rod slidably sleeved in the piston cylinder, a first reset member that provides a reset force to the piston rod, and a feedback pressure cylinder sleeved on the rod end of the piston rod. The tactile feedback cylinder is used to transmit tactile pressure to the piston rod, and its tactile fingers contact the corresponding tactile feedback range indicator.

3. A sliding multi-range volume control device according to claim 1 or 2, characterized in that, The range shifting assembly includes a knob, a shifting lever fixedly connected to the knob at one end, a shifting fixing inner ring and a guide wheel inner ring that are alternately sleeved on the outer wall of the shifting lever. Each pressure generator is provided with a corresponding inner ring of the guide wheel, and each inner ring of the guide wheel corresponds to a gear position; Each of the guide wheel inner rings is further fitted with a guide wheel, and the inner ring of the guide wheel and the middle part of the guide wheel are respectively provided with corresponding locking holes perpendicular to their axis; The gear shift lever includes a shift lever body and an elastic locking protrusion disposed on the side of the shift lever body, and the elastic locking protrusion is operablely engaged in the locking hole of the corresponding gear.

4. The sliding multi-range volume control device according to claim 3, characterized in that, The displacement transmission component is a wire, and the wire is arranged in a closed loop, with one end of the closed loop wrapped around the wire wheel. The other end of the closed loop of the conductor passes through the corresponding range feedback element and is rotatably connected to the pulley on the irregular support bracket. When passing through the corresponding range feedback element, one side is fixedly connected to the range feedback element, and the other side is slidably connected to the range feedback element.

5. A sliding multi-range volume control device according to claim 1 or 2, characterized in that, The irregular support bracket includes a gear shift bracket, a pressure generator bracket, and a range scale; The gear shift bracket is vertically mounted on the top of the pressure generator bracket, and the range scale is vertically fixed to the side of the pressure generator bracket to indicate the movement position of the tactile feedback range indicator.

6. A sliding multi-range volume control device according to claim 5, characterized in that, The pressure generator bracket includes a first frame and a second frame arranged parallel to each other from top to bottom. The outer wall of the first frame extends outward along its circumference with piston cylinder rod end fasteners corresponding to the number of pressure generators. The outer wall of the second frame extends outward along its circumference with piston cylinder rodless end fasteners corresponding to the number of pressure generators; The inner wall of the second frame is provided with pulleys corresponding to the number of pressure generators, so that the other end of the displacement transmission component can be rotatably connected; Furthermore, a guide rod corresponding to the number of pressure generators is provided between the first frame and the second frame, and each range feedback element is slidably mounted on the corresponding guide rod.

7. A sliding multi-range volume control device according to claim 5, characterized in that, The gear shifting bracket includes a vertical support column and several horizontal support columns cantilevered on one side of the vertical support column. The horizontal support columns are fixedly installed at equal intervals from top to bottom on one side of the vertical support columns; Each of the horizontal support columns has a sleeve at its cantilever end, and the sleeves are coaxially arranged. The range switching component is rotatably arranged in each of the coaxially arranged sleeves. The cantilever end of the horizontal support column at the lowest position is provided with several guide members along the circumference of its corresponding sleeve to support the displacement transmission member.

8. A sliding multi-range volume control device according to claim 2, characterized in that, The range feedback device includes a piston cylinder fixing ring through which the piston cylinder passes. The outer walls of the piston cylinder fixing ring extend outward from opposite sides, and blind holes are provided on the blind holes along their thickness direction. A second reset device is provided in the blind holes to provide reset force for the touch feedback pressure cylinder. The piston cylinder retaining ring is also provided with an irregularly shaped range pointer on its outer wall, which is used to indicate the preset volume feed amount in the current gear.

9. A multi-range pipette, characterized in that, It includes a housing assembly, a sliding multi-range volume control device, a pressure transmission assembly, and a mixing control assembly disposed within the housing assembly, as well as an integrated drug compartment that can be detached from the housing assembly; The sliding multi-range volume control device includes a range switching component and at least two pressure generators for generating release pressure or suction pressure. The range switching component has the same number of ranges as the number of pressure generators and is used to switch to the corresponding range so that the corresponding pressure generator generates pressure for the corresponding preset volume. The pressure outlets of each pressure generator are connected together to form a total pressure outlet, and the total pressure outlet is connected to the first transmission port of the pressure transmission assembly. The second transmission port of the pressure transmission component is connected to the integrated drug tank, and the integrated drug tank is connected to a pipette tip. The air outlet of the mixing control component is connected to the integrated drug container, and is used to release mixing pressure to the integrated drug container so that the reagents inside reach a uniform state.

10. A pipetting method using a multi-range pipette as described in claim 9, characterized in that, The steps include: First, adjust the range switching component to the range corresponding to the preset volume, and then uniformly adjust the range feedback component corresponding to each range to the corresponding preset volume position. Then switch the pressure transmission component to the corresponding channel, and then start the pressure generators with different ranges in sequence until the touch finger on each pressure generator touches the corresponding range feedback element to complete the distribution of non-integer units of liquid.

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