Blood sample centrifugal pretreatment device for myocardial infarction emergency treatment marker detection

Abstract

The invention relates to the technical field of blood sample centrifugal pretreatment, in particular to a blood sample centrifugal pretreatment device for myocardial infarction emergency marker detection, which comprises a treatment device body, and centrifugal equipment for centrifuging a blood sample is arranged in the treatment device body; the centrifugal equipment mainly comprises a rotating shaft rotationally arranged in the treatment device body; a clutch mechanism and a hold-down structure which are matched for use are arranged above the rotary table, the clutch mechanism comprises a mounting shaft, a clutch assembly and a rotating seat which are arranged above the rotary table, and the clutch assembly is connected with the mounting shaft. According to the blood sample centrifugal pretreatment device for myocardial infarction emergency treatment marker detection, the pressing and holding structure is driven by the clutch mechanism to intermittently press and fix a sample test tube in the centrifugal process, so that the test tube is effectively prevented from shaking or popping up due to the action of centrifugal force during high-speed centrifugation, and the stability and safety of the centrifugal process are ensured; the centrifugal pretreatment quality of the blood sample is improved.

Description

Technical Field

[0001] This application relates to the field of blood sample centrifugation pretreatment technology, and in particular to a blood sample centrifugation pretreatment device for the detection of emergency biomarkers for myocardial infarction. Background Technology

[0002] Currently, the widely used blood sample centrifugation pretreatment devices in clinical practice mainly consist of a drive motor, a rotating rotor, sample receiving ports, and a cover. The standard operating procedure is to place the blood sample collected in a vacuum blood collection tube into the rotor port, and the centrifugal force generated by high-speed rotation separates the formed elements from the intangible components in the blood.

[0003] However, existing centrifugal pretreatment devices suffer from a long-overlooked but crucial design flaw: the lack of a dedicated mechanical structure for effectively holding or locking the sample tube caps during centrifugation. During use, centrifugation generates significant stress. If the sample tube caps are not tightened sufficiently or due to inherent sealing defects, pathogens such as HBV, HCV, and HIV may leak from the cap gaps or atomize into aerosols under high-speed centrifugation. These aerosols can escape into the centrifuge chamber, contaminating the rotor, chamber walls, and other samples. When the centrifuge cap is opened, these pathogen-containing aerosols are directly exposed to the operating environment, posing a serious biosafety threat to healthcare workers. Furthermore, there is a risk of cross-contamination between samples, potentially leading to erroneous test results.

[0004] Furthermore, an incompletely sealed cap can cause moisture evaporation from the sample. For trace samples, evaporation can lead to sample concentration, artificially inflating the concentration of cardiac markers and resulting in false positives or inflated test results, which can seriously mislead clinical diagnosis. Therefore, a blood sample centrifugation pretreatment device for detecting cardiac markers in the emergency department of myocardial infarction is proposed to address the aforementioned problems. Summary of the Invention

[0005] To address the shortcomings of existing technologies and prevent sample tube caps from loosening during centrifugation, this application provides a blood sample centrifugation pretreatment device for detecting emergency markers of myocardial infarction. This device utilizes a mechanical linkage structure, eliminating the need for additional manual operation, thus improving the automation level of the equipment, reducing human intervention, and lowering the difficulty and labor intensity of operation. It has advantages such as high automation and the ability to hold the sample caps during centrifugation, solving the problem of the lack of effective holding of sample tube caps during centrifugation.

[0006] This application provides a blood sample centrifugation pretreatment device for detecting emergency biomarkers of myocardial infarction, employing the following technical solution:

[0007] A blood sample centrifugation pretreatment device for detecting emergency markers of myocardial infarction includes a processing device body, wherein a centrifugation device for centrifuging blood samples is provided inside the processing device body.

[0008] The centrifuge mainly includes a rotating shaft rotatably disposed inside the body of the processing device, a turntable fixed to the top of the rotating shaft, and a drive assembly installed inside the body of the processing device and between the rotating shaft. The turntable has a sample slot for fixing the sample inside.

[0009] The turntable is provided with a clutch mechanism and a holding structure for cooperation. The clutch mechanism includes a mounting shaft, a clutch assembly and a rotating seat provided on the turntable. The clutch assembly is connected to the mounting shaft.

[0010] The clutch assembly includes a rotor fixed to the outer surface of the mounting shaft. An abutment block is provided on the outside of the rotor, which intermittently abuts against the rotating seat. A telescopic shaft that is telescopically connected to the inside of the rotor is installed on the outer wall of the abutment block. A rotating sleeve and a sliding sleeve are provided above the rotor and are sleeved on the outer surface of the mounting shaft. A connecting rod is hinged between the rotating sleeve and the abutment block. The holding structure is connected to the outer surface of the sliding sleeve.

[0011] Optionally: the processing device body includes a housing, a cover is hinged to one side of the housing, a handle is bolted to the upper surface of the cover, a controller is installed on the outer wall of the housing, and the centrifuge is located inside the housing.

[0012] Optionally: The housing has an internal mounting slot for mounting the drive assembly, the bottom end of the rotating shaft is connected to a bearing on the bottom wall of the mounting slot, and the drive assembly consists of a drive motor and two meshing gears.

[0013] Optionally: A limiting frame for limiting the mounting shaft is installed on the upper surface of the turntable, and a liquid storage component for lubricating the drive assembly is provided on the side wall of the limiting frame, which works in conjunction with the rotating seat.

[0014] Optionally: the rotating seat is rotatably mounted on the upper surface of the limiting frame, the interior of the rotating seat is hollow, and the mounting shaft passes through the interior of the rotating seat.

[0015] Optionally: The rotor has an extension groove inside, and the end of the telescopic shaft away from the abutment block extends into the extension groove. A first return spring is installed between the inner wall of the extension groove and the end of the telescopic shaft.

[0016] Optionally: the sliding sleeve and the rotating sleeve are distributed vertically, and the opposite side of the sliding sleeve and the rotating sleeve is rotatably connected. A second return spring is installed between the rotating sleeve and the rotor, surrounding the outside of the mounting shaft.

[0017] Optionally: The pressing structure includes a connecting arm fixed to the outer surface of the sliding sleeve. The connecting arm is L-shaped, and the other end of the connecting arm faces the sample groove. A pressure block is bolted to the end of the connecting arm away from the sliding sleeve.

[0018] Optionally, the pressing structure further includes a guide rod fixed to the upper surface of the turntable, a third return spring is installed on the outer surface of the guide rod, and a connecting sleeve is fixed to one side of the pressing block, which is sleeved on the outer surface of the guide rod and fixed to the top side of the third return spring.

[0019] Optionally: The liquid storage assembly includes a liquid storage box fixed to the outer wall of the limiting frame, a stirring rod extending outward is rotatably installed inside the liquid storage box, a synchronizing element is installed between the top end of the stirring rod and the outer surface of the rotating seat, and an infusion pipe penetrating the interior of the turntable is installed on the bottom flange of the liquid storage box, and a sealing plug is inserted into the bottom end of the infusion pipe.

[0020] In summary, this application includes at least one of the following beneficial technical effects:

[0021] 1. In this invention, the holding structure, driven by the clutch mechanism, intermittently holds and fixes the sample tube during centrifugation, effectively preventing the tube from shaking or popping out due to centrifugal force during high-speed centrifugation, ensuring the stability and safety of the centrifugation process, and improving the quality of blood sample centrifugation pretreatment.

[0022] 2. This invention utilizes the linkage of mechanical structures, using the rotation of the turntable to drive the clutch mechanism, thereby achieving automatic pressing and resetting of the pressing structure. No additional manual operation is required, which improves the automation level of the equipment, reduces human intervention, and lowers the difficulty of operation and labor intensity.

[0023] 3. This invention, through the setting of the liquid storage component, can lubricate the drive component during equipment operation. The rotating seat drives the stirring rod to stir the lubricating fluid, preventing the lubricating fluid from settling and ensuring the lubrication effect. Then, the lubricating fluid can be conveniently delivered to the parts that need lubrication through the infusion pipe, which extends the service life of the drive component and improves the reliability and stability of the equipment. Attached Figure Description

[0024] Figure 1 This is a three-dimensional structural view of this application;

[0025] Figure 2 This is a cross-sectional view of the structure of this application;

[0026] Figure 3 This is a schematic diagram of the retaining structure of this application;

[0027] Figure 4This is a schematic diagram of the clutch mechanism of this application;

[0028] Figure 5 This application Figure 4 A magnified structural diagram of structure A is shown below;

[0029] Figure 6 This application Figure 2 A magnified schematic diagram of structure B is shown.

[0030] Explanation of reference numerals in the attached figures:

[0031] 1. Processing device body; 11. Housing; 111. Mounting slot; 12. Cover; 13. Handle; 14. Controller; 2. Centrifuge equipment; 21. Rotating shaft; 22. Turntable; 221. Sample tank; 23. Drive assembly; 24. Limiting frame; 3. Clutch mechanism; 31. Mounting shaft; 32. Clutch assembly; 321. Rotor; 322. Abutment block; 323. Rotating sleeve; 324. Sliding sleeve; 325. Connecting rod; 326. Telescopic shaft; 327. First return spring; 328. Second return spring; 33. Rotating seat; 4. Holding structure; 41. Connecting arm; 42. Pressing block; 43. Guide rod; 44. Connecting sleeve; 45. Third return spring; 5. Liquid storage assembly; 51. Liquid storage box; 52. Stirring rod; 53. Infusion tube; 54. Synchronizing component. Detailed Implementation

[0032] The following is in conjunction with the appendix Figures 1-6 This application will be described in further detail.

[0033] Example 1, as Figure 1 As shown, the blood sample centrifugation pretreatment device for detecting emergency markers of myocardial infarction in this embodiment includes a processing device body 1, wherein the processing device body 1 includes a housing 11, and a cover 12 is hinged to one side of the housing 11. A handle 13 is bolted to the upper surface of the cover 12, wherein the bolt is a tensioning bolt, which can adjust the tightness of the handle 13; a controller 14 is installed on the outer wall of the housing 11; by connecting the cover 12 to the housing 11 in a hinged manner, the cover 12 can be opened and closed flexibly. When performing emergency marker detection of myocardial infarction, medical staff can easily open the cover 12 and accurately place the test tube containing the blood sample into the designated position of the centrifugation pretreatment device to complete the sample loading operation.

[0034] Furthermore, through the controller 14, operators can precisely set various parameters of the centrifugation pretreatment, such as centrifugation speed, centrifugation time, and temperature, to meet the requirements of different blood samples and testing items. For example, for the detection of emergency markers for myocardial infarction, specific centrifugation conditions may be required to separate serum or plasma. The controller 14 can ensure that the equipment operates accurately according to the preset parameters, improving the accuracy and reliability of the test results.

[0035] Example 2, as follows Figures 2-5 As shown, to achieve the detection of emergency markers for myocardial infarction, a centrifuge device 2 for centrifuging blood samples is installed inside the processing device body 1; specifically, the centrifuge device 2 is located inside the housing 11. The centrifuge device 2 mainly includes a rotating shaft 21 rotatably installed inside the processing device body 1, a turntable 22 fixed to the top of the rotating shaft 21, and a drive assembly 23 installed inside the processing device body 1 and between the rotating shaft 21. The turntable 22 has a sample slot 221 for sample fixation. It should be noted that the housing 11 has a mounting slot 111 for mounting the drive assembly 23. The bottom end of the rotating shaft 21 is connected to the bearing on the bottom wall of the mounting slot 111. The drive assembly 23 consists of a drive motor and two meshing gears. When the rotating shaft 21 is driven to rotate by the drive assembly 23, the turntable 22 can rotate synchronously and stably, providing a stable centrifugal force for the blood sample, ensuring that different components in the sample can be effectively separated, and meeting the sample pretreatment requirements for the detection of emergency markers for myocardial infarction.

[0036] To prevent specimen leakage, a clutch mechanism 3 and a holding structure 4 are provided above the turntable 22 for cooperation. The clutch mechanism 3 includes a mounting shaft 31, a clutch assembly 32 and a rotating seat 33 located above the turntable 22. The clutch assembly 32 is connected to the mounting shaft 31. The clutch assembly 32 includes a rotor 321 fixed to the outer surface of the mounting shaft 31. An abutment block 322 is provided on the outside of the rotor 321, which intermittently abuts against the rotating seat 33. A telescopic shaft 326 is installed on the outer wall of the abutment block 322, which is telescopically connected to the inside of the rotor 321. A rotating sleeve 323 and a sliding sleeve 324 are provided above the rotor 321 and sleeved on the outer surface of the mounting shaft 31. A connecting rod 325 is hinged between the rotating sleeve 323 and the abutment block 322. The holding structure 4 is connected to the outer surface of the sliding sleeve 324.

[0037] Specifically, a limiting frame 24 is mounted on the upper surface of the turntable 22 to limit the movement of the mounting shaft 31, and the mounting shaft 31 is rotatably connected to the limiting frame 24. A rotating seat 33 is rotatably mounted on the upper surface of the limiting frame 24. The interior of the rotating seat 33 is hollow, and the mounting shaft 31 passes through the interior of the rotating seat 33. An extension groove is provided inside the rotor 321, and the end of the telescopic shaft 326 away from the abutment block 322 extends into the extension groove. A first return spring 327 is installed between the inner wall of the extension groove and the end of the telescopic shaft 326.

[0038] It should be noted that the sliding sleeve 324 and the rotating sleeve 323 are distributed vertically, and the opposite sides of the sliding sleeve 324 and the rotating sleeve 323 are rotatably connected. A second return spring 328 is installed between the rotating sleeve 323 and the rotor 321, surrounding the outside of the mounting shaft 31. When the abutment block 322 separates from the rotating seat 33, the second return spring 328 can quickly pull the rotating sleeve 323 back to its initial position, thereby driving the sliding sleeve 324 and the pressing structure 4 to reset, preparing for the next pressing action, and ensuring the continuous and stable operation of the clutch mechanism 3. There are at least two abutment blocks 322, and the outer surface of the abutment block 322 is equipped with an anti-slip pad that abuts against the inner side of the rotating seat 33, thereby improving the abutment effect between the abutment block 322 and the rotating seat 33.

[0039] In this embodiment, when the centrifuge device 2 is started, the turntable 22 begins to rotate, generating centrifugal force. At this time, the abutment block 322 in the clutch mechanism 3, under the action of centrifugal force, overcomes the elastic force of the first return spring 327 and is thrown outward, finally abutting against the inner wall of the fixed rotating seat 33. At this time, the rotating sleeve 323 is forced to move downward, compressing the second return spring 328. When the rotating sleeve 323 moves downward, it will drive the sliding sleeve 324, which rotates relative to it, to move downward together. The downward movement of the sliding sleeve 324 drives the connecting arm 41 and the lower end pressure block 42 to move downward steadily along the guide rod 43, compressing the third return spring 45, so that the pressure block 42 is finally firmly pressed on the cap of the sample tube. Moreover, the greater the centrifugal force, the greater the friction force generated by the abutment block 322, the greater the potential energy of the rotating sleeve 323 moving downward, and the greater the final pressing force applied to the tube cap, thus realizing automatic pressing force adjustment synchronized with the centrifugation speed.

[0040] To achieve specimen cover clamping, the clamping structure 4 includes a connecting arm 41 fixed to the outer surface of the sliding sleeve 324. The connecting arm 41 is L-shaped, with one end facing the sample slot 221. A clamping block 42 is bolted to the end of the connecting arm 41 away from the sliding sleeve 324. Specifically, the clamping structure 4 also includes a guide rod 43 fixed to the upper surface of the turntable 22. A third return spring 45 is installed on the outer surface of the guide rod 43. A connecting sleeve 44, which is sleeved on the outer surface of the guide rod 43 and fixed to the top side of the third return spring 45, is fixed to one side of the clamping block 42. The connecting rod 325 pushes the rotating sleeve 323 and the sliding sleeve 324 upward, thereby causing the clamping structure 4 to clamp the specimen cover. When clamping is not required, the abutment block 322 separates from the rotating seat 33, and the clamping structure 4 releases the specimen cover under the action of the return spring, achieving precise control of specimen cover clamping.

[0041] Furthermore, the guide rod 43 provides precise guidance for the up-and-down movement of the pressure block 42, ensuring that the pressure block 42 can be pressed vertically and accurately onto the specimen cover; the third return spring 45 can quickly pull the pressure block 42 back to its initial position after the pressing action is completed, cooperating with the reset action of the clutch mechanism 3 to make the reset of the pressing structure 4 more stable and rapid.

[0042] Example 3, such as Figure 2 and Figure 6 As shown, a liquid storage assembly 5 is provided on the side wall of the limiting frame 24, which works in conjunction with the rotating seat 33 and is used for lubricating the drive assembly 23. Specifically, the liquid storage assembly 5 includes a liquid storage box 51 fixed to the outer wall of the limiting frame 24. A stirring rod 52 extending outward is rotatably mounted inside the liquid storage box 51. A synchronizing element 54 is installed between the top of the stirring rod 52 and the outer surface of the rotating seat 33. A delivery pipe 53 penetrating the interior of the turntable 22 is installed on the bottom flange of the liquid storage box 51, and a sealing plug is inserted into the bottom end of the delivery pipe 53. The liquid storage box 51 in the liquid storage assembly 5 is used to store lubricating oil. When the rotating seat 33 rotates, the synchronizing element 54 drives the stirring rod 52 to rotate inside the liquid storage box 51, so that the lubricating oil can be kept in a uniform state under the stirring of the stirring rod 52, and delivered to the drive assembly 23 through the delivery pipe 53. It should be noted that the delivery pipe 53 can deliver oil when the drive assembly 23 is not working or after it has stopped.

[0043] It is worth mentioning that during long-term operation, friction between gears in the drive assembly 23 can lead to component wear and reduce the service life of the equipment. The continuous lubrication provided by the liquid reservoir 5 can effectively reduce this wear and lower the failure rate of components. When the gears are lubricated by the lubricating oil, the direct contact between the gear teeth is reduced, the wear rate is significantly reduced, thereby extending the service life of the gears, and thus extending the service life of the entire drive assembly 23 and the centrifuge 2.

[0044] Combined with appendix Figures 1-6 The working principle of the above embodiments is as follows:

[0045] When the centrifuge is stationary, it stops rotating and the centrifugal force is zero. Under the action of the second return spring 328, the rotating sleeve 323 is pushed upward. The rotating sleeve 323 pulls the abutment block 322 inward through the connecting rod 325, overcoming the force of the first return spring 327 and separating it from the rotating seat 33. At this time, the entire pressing structure 4 connected to the sliding sleeve 324 is lifted under the elastic force of the third return spring 45, and the pressing block 42 is in a high position, leaving enough space for the operator to put in or take out the sample tube.

[0046] Then, when the centrifuge 2 is started, the turntable 22 begins to rotate, generating centrifugal force. At this time, the abutment block 322 in the clutch mechanism 3, under the action of centrifugal force, overcomes the elastic force of the first return spring 327 and is thrown outward, finally abutting against the inner wall of the fixed rotating seat 33. At this time, the rotating sleeve 323 is forced to move downward, compressing the second return spring 328. When the rotating sleeve 323 moves downward, it will drive the sliding sleeve 324, which rotates relative to it, to move downward together. The downward movement of the sliding sleeve 324 drives the connecting arm 41 and the lower end pressure block 42 to move downward steadily along the guide rod 43, compressing the third return spring 45, so that the pressure block 42 is finally firmly pressed on the cap of the sample tube. Moreover, the greater the centrifugal force, the greater the friction force generated by the abutment block 322, the greater the potential energy of the rotating sleeve 323 moving downward, and the greater the final pressing force applied to the tube cap, thus realizing automatic pressing force adjustment synchronized with the centrifugation speed.

[0047] The above are all preferred embodiments of this application, and are not intended to limit the scope of protection of this application. Therefore, all equivalent changes made in accordance with the structure, shape and principle of this application should be covered within the scope of protection of this application.

Claims

1. A blood sample centrifugation pretreatment device for detecting emergency markers of myocardial infarction, comprising a processing device body (1), characterized in that: The processing device body (1) is equipped with a centrifugation device (2) for centrifuging blood samples; The centrifuge device (2) mainly includes a rotating shaft (21) rotatably disposed inside the processing device body (1), a turntable (22) fixed to the top of the rotating shaft (21), and a drive assembly (23) installed inside the processing device body (1) and between the rotating shaft (21). The turntable (22) has a sample slot (221) for sample fixation inside. The turntable (22) is provided with a clutch mechanism (3) and a pressing structure (4) for use. The clutch mechanism (3) includes a mounting shaft (31), a clutch assembly (32) and a rotating seat (33) provided above the turntable (22). The clutch assembly (32) is connected to the mounting shaft (31). The clutch assembly (32) includes a rotor (321) fixed to the outer surface of the mounting shaft (31). The rotor (321) is provided with an abutment block (322) that intermittently abuts against the rotating seat (33). The outer wall of the abutment block (322) is equipped with a telescopic shaft (326) that is telescopically connected to the inside of the rotor (321). A rotating sleeve (323) and a sliding sleeve (324) are provided above the rotor (321) and are sleeved on the outer surface of the mounting shaft (31). A connecting rod (325) is hinged between the rotating sleeve (323) and the abutment block (322). The pressing structure (4) is connected to the outer surface of the sliding sleeve (324).

2. The blood sample centrifugation pretreatment device for detecting emergency biomarkers of myocardial infarction according to claim 1, characterized in that: The processing device body (1) includes a housing (11), a cover (12) is hinged to one side of the housing (11), a handle (13) is bolted to the upper surface of the cover (12), a controller (14) is installed on the outer wall of the housing (11), and the centrifuge (2) is located inside the housing (11).

3. The blood sample centrifugation pretreatment device for detecting emergency biomarkers of myocardial infarction according to claim 2, characterized in that: The housing (11) has an internal mounting slot (111) for mounting the drive assembly (23). The bottom end of the rotating shaft (21) is connected to the bearing on the bottom wall of the mounting slot (111). The drive assembly (23) consists of a drive motor and two meshing gears.

4. The blood sample centrifugation pretreatment device for detecting emergency biomarkers of myocardial infarction according to claim 1, characterized in that: The upper surface of the turntable (22) is equipped with a limiting frame (24) for limiting the mounting shaft (31), and the side wall of the limiting frame (24) is provided with a liquid storage component (5) that works with the rotating seat (33) and is used for lubrication of the drive assembly (23).

5. The blood sample centrifugation pretreatment device for detecting emergency biomarkers of myocardial infarction according to claim 4, characterized in that: The rotating seat (33) is rotatably mounted on the upper surface of the limiting frame (24). The interior of the rotating seat (33) is hollow, and the mounting shaft (31) passes through the interior of the rotating seat (33).

6. The blood sample centrifugation pretreatment device for detecting emergency biomarkers of myocardial infarction according to claim 1, characterized in that: An extension groove is provided inside the rotor (321), and the end of the telescopic shaft (326) away from the abutment block (322) extends into the extension groove. A first return spring (327) is installed between the inner wall of the extension groove and the end of the telescopic shaft (326).

7. The blood sample centrifugation pretreatment device for detecting emergency biomarkers of myocardial infarction according to claim 1, characterized in that: The sliding sleeve (324) and the rotating sleeve (323) are distributed vertically, and the sliding sleeve (324) and the rotating sleeve (323) are rotatably connected on opposite sides. A second return spring (328) is installed between the rotating sleeve (323) and the rotor (321) and surrounds the outside of the mounting shaft (31).

8. The blood sample centrifugation pretreatment device for detecting emergency biomarkers of myocardial infarction according to claim 1, characterized in that: The pressing structure (4) includes a connecting arm (41) fixed to the outer surface of the sliding sleeve (324). The connecting arm (41) is L-shaped, and the other end of the connecting arm (41) faces the sample groove (221). A pressure block (42) is bolted to the end of the connecting arm (41) away from the sliding sleeve (324).

9. The blood sample centrifugation pretreatment device for detecting emergency biomarkers of myocardial infarction according to claim 8, characterized in that: The pressing structure (4) also includes a guide rod (43) fixed to the upper surface of the turntable (22). A third return spring (45) is installed on the outer surface of the guide rod (43). A connecting sleeve (44) is fixed on one side of the pressing block (42), which is sleeved on the outer surface of the guide rod (43) and fixed to the top side of the third return spring (45).

10. The blood sample centrifugation pretreatment device for detecting emergency biomarkers of myocardial infarction according to claim 4, characterized in that: The liquid storage assembly (5) includes a liquid storage box (51) fixed to the outer wall of the limiting frame (24). A stirring rod (52) extending outward is rotatably installed inside the liquid storage box (51). A synchronizing element (54) is installed between the top of the stirring rod (52) and the outer surface of the rotating seat (33). An infusion pipe (53) penetrating the inside of the turntable (22) is installed on the bottom flange of the liquid storage box (51). A sealing plug is inserted into the bottom end of the infusion pipe (53).

Images