Injection device, split charging device, split charging instrument and split charging method

Abstract

The invention belongs to the technical field of medical instruments, and particularly relates to an injection device, a split charging device, a split charging instrument and a split charging method. The injection device comprises an injector, an air filter and a flexible pipe with an internal space; the injector comprises a push rod and an injection tube provided with an inner hole, and a piston inserted into the inner hole is arranged on the push rod; the flexible tube is mounted on the injection tube, and one end, far away from the piston, of the push rod extends into the internal space and is connected with the flexible tube; and the air filter is communicated with the internal space. According to the injection device, the flexible pipe can play a role in protecting the push rod, the accident that an injector and liquid are polluted when a hand makes contact with the push rod is avoided, and the safety of the injection device is guaranteed; the air filter can balance the air pressure in the internal space, the resistance borne by the push rod in the moving process is reduced, the push rod is conveniently pushed, and the moving precision of the push rod is guaranteed.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of medical devices, in particular to an injection device, a split charging device, a split charging instrument and a split charging method. BACKGROUND

[0002] Cell therapy technology refers to transplanting or inputting normal or bioengineered human cells into patients, the newly input cells can replace, repair damaged cells, or stimulate the immune system, have stronger immune killing function, so as to achieve the purpose of treating diseases.

[0003] The cell solution is generally stored in a packaging bag, and when cell therapy is performed, the cell solution in the large packaging bag needs to be split charged into a small packaging bag. In the prior art, the staff usually uses a syringe to split charge the cell solution into a packaging bag, but in the process of manually pushing the syringe, the syringe and the cell solution are easily contaminated, and manual split charging is inaccurate and easily affected by vision and the outside world, so the accuracy and precision are not high. SUMMARY

[0004] The technical problem to be solved by the present application is that the syringe and the cell solution are easily contaminated in the process of manually pushing the syringe, and an injection device, a split charging device, a split charging instrument and a split charging method are provided.

[0005] To solve the above technical problems, the first embodiment of the present application provides an injection device, which comprises a syringe, an empty filter and a flexible tube provided with an internal space; the syringe comprises a push rod and a syringe tube provided with an inner hole, and a piston is arranged on the push rod and inserted into the inner hole;

[0006] The flexible tube is installed on the syringe tube, one end of the push rod away from the piston extends into the internal space and is connected to the flexible tube, and the empty filter communicates with the internal space.

[0007] Optionally, the injection device further comprises a sleeve, the sleeve is sleeved on the syringe tube, and the flexible tube is sleeved on the sleeve.

[0008] Optionally, a flange is further arranged on the syringe tube, a first mounting hole is arranged on the flange, a second mounting hole is arranged on the sleeve, and the sleeve is sleeved on the syringe tube through fasteners inserted into the first mounting hole and the second mounting hole.

[0009] Optionally, an insertion slot communicating with the internal space is further arranged on the flexible tube, and an insertion part is arranged on one end of the push rod away from the piston, and the insertion part is inserted into the insertion slot.

[0010] The second embodiment of the present application provides a sub-packaging device, which comprises an injection three-way valve, a plurality of sub-packaging three-way valves, a plurality of sub-packaging conduits and the injection device described above.

[0011] The first interface of the injection three-way valve is communicated with the inner hole, the second interface of the injection three-way valve is communicated with the first interface of the sub-packaging three-way valve, and the third interface of the sub-packaging three-way valve is communicated with the sub-packaging conduit one by one.

[0012] Optionally, the sub-packaging device further comprises a first filter and a mixing three-way valve.

[0013] The second interface of the injection three-way valve is communicated with the first interface of the mixing three-way valve, the second interface of the mixing three-way valve is communicated with the first filter, and the third interface of the mixing three-way valve is used for communicating with an external sub-packaging bag.

[0014] Optionally, the sub-packaging device further comprises a second filter and a pressure sensor detachably connected with the second filter.

[0015] One end of the second filter is communicated with the sub-packaging conduit, and the other end is communicated with the pressure sensor.

[0016] The pressure sensor is used for detecting the air pressure in the sub-packaging conduit.

[0017] Optionally, the sub-packaging device further comprises a support plate, and a plurality of buckles are arranged on the support plate, and the sub-packaging conduit is inserted into the buckle one by one.

[0018] Optionally, the sub-packaging device further comprises a support plate, and the injection three-way valve and the sub-packaging three-way valve are detachably installed on the support plate.

[0019] The third embodiment of the present application provides a sub-packaging instrument, which comprises the sub-packaging device described above.

[0020] The fourth embodiment of the present application provides a sub-packaging method applied to the sub-packaging device described above, and the method comprises the following steps.

[0021] The flow direction of the injection three-way valve and the push rod of the injection device are controlled, so that the sample liquid in the external sub-packaging bag flows into the injection pipe, and the push rod is stopped when the preset capacity is reached.

[0022] The flow direction of the injection three-way valve and the flow direction of each sub-packaging three-way valve are switched, and the push rod of the injection device is pushed, so that the sample liquid in the injection device is sub-packaged into the storage bag corresponding to each sub-packaging conduit.

[0023] Optionally, the control of the flow direction of the injection three-way valve and the push rod of the injection device, before allowing the sample solution in the external dispensing bag to flow into the injection tube, further includes:

[0024] Controlling the flow direction of the injection three-way valve and the dispensing three-way valve, and controlling the push rod of the injection device, causes the syringe to draw gas from each of the storage bags and discharge it.

[0025] Optionally, controlling the flow direction of the injection three-way valve and the dispensing three-way valve, and controlling the plunger of the injection device to cause the syringe to draw gas from each of the storage bags and discharge it, includes:

[0026] The second port of the injection three-way valve is connected to the first port of the mixing three-way valve, the second port of the mixing three-way valve is connected to the first filter, and the third port of the mixing three-way valve is connected to the external bag to be dispensed.

[0027] After controlling the pipeline between the first filter and the inner hole to be closed and the pipeline between the inner hole and all the dispensing conduits to be open by the injection three-way valve, the dispensing three-way valve and the mixing three-way valve, the push rod is controlled to put each storage bag into a near-vacuum state.

[0028] After controlling the pipeline between the inner hole and all the dispensing conduits to be closed by the injection three-way valve, the dispensing three-way valve and the mixing three-way valve, and controlling the pipeline between the first filter and the inner hole to be open, the syringe is controlled to discharge the gas in the inner hole through the first filter.

[0029] Optionally, after controlling the tubing between the second filter and the inner bore to be closed, and controlling the tubing between the inner bore and all the dispensing conduits to be open, controlling the syringe to bring each storage bag into a near-vacuum state includes:

[0030] Control the third port of the dispensing three-way valve, which is located away from the injection three-way valve, to connect to the pressure sensor; control the pressure sensor to connect to all the dispensing conduits and the inner hole through the injection three-way valve, the dispensing three-way valve, and the mixing three-way valve, and control the pipeline between the pressure sensor and the inner hole to be in a closed state;

[0031] The push rod is controlled to extract gas from each external bag to be dispensed, and the pressure sensor is controlled to detect the pressure value of all the bags in real time.

[0032] When the pressure value detected by the pressure sensor reaches the preset pressure value, it indicates that the syringe has put each of the storage bags into a near-vacuum state.

[0033] In this invention, the flexible tube is mounted on the injection tube, and the end of the push rod away from the piston extends into the internal space and connects to the flexible tube. The air filter is connected to the internal space. Pressing the flexible tube moves the push rod, which in turn moves the piston within the injection tube's inner bore, allowing the syringe to draw or push liquid or gas. The flexible tube protects the push rod and prevents contamination of the syringe and liquid caused by hand contact with the push rod, ensuring the safety of the injection device. Furthermore, it maintains a sterile environment and improves dispensing accuracy and precision by accurately controlling the push rod to dispense liquids with high precision.

[0034] In addition, during the compression of the flexible tube, external gas can enter the internal space through the air filter. The air filter ensures that the gas entering the internal space is sterile and will not contaminate the liquid or gas in the inner hole, thus ensuring that the pipeline is in a sterile environment. Moreover, when the push rod drives the piston towards the injection port, the air filter can equalize the air pressure in the internal space, reduce the resistance encountered by the push rod during its movement, facilitate the push rod's movement, and ensure the accuracy of the push rod's movement. Attached Figure Description

[0035] The present invention will be further described below with reference to the accompanying drawings and embodiments.

[0036] Figure 1 This is a front view of an injection device provided in an embodiment of the present invention;

[0037] Figure 2 This is a cross-sectional view of an injection device provided in an embodiment of the present invention;

[0038] Figure 3 This is a front view of a dispensing apparatus provided in an embodiment of the present invention;

[0039] Figure 4 This is a flowchart of a packaging method provided in an embodiment of the present invention.

[0040] The reference numerals in the accompanying drawings are as follows:

[0041] 1. Injection device; 11. Syringe; 111. Push rod; 1111. Piston; 1112. Insertion part; 112. Injection tube; 1121. Inner hole; 1122. Flanged edge; 12. Air filter; 13. Flexible tube; 131. Internal space; 132. Insertion groove; 14. Sleeve.

[0042] 2. Injection three-way valve; 3. Mixing three-way valve; 4. First filter; 5. Second filter; 6. Dispensing three-way valve; 7. Dispensing conduit; 8. Support plate; 81. Clip. Detailed Implementation

[0043] To make the technical problems solved, the technical solutions, and the beneficial effects of this invention clearer, the invention will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only for explaining the invention and are not intended to limit the invention.

[0044] It should be understood that the terms "upper", "lower", "left", "right", "front", "rear", "middle", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations of the present invention.

[0045] like Figure 1 and Figure 2 As shown, the first embodiment of the present invention provides an injection device 1, including a syringe 11, an air filter 12, and a flexible tube 13 with an internal space 131; the syringe 11 includes a push rod 111 and an injection tube 112 with an inner hole 1121, and the push rod 111 is provided with a piston 1111 inserted into the inner hole 1121; it can be understood that the flexible tube 13 includes, but is not limited to, a corrugated tube, etc., and the end of the injection tube 112 away from the flexible tube 13 is provided with an injection port communicating with the inner hole 1121.

[0046] The flexible tube 13 is mounted on the injection tube 112, and the end of the push rod 111 away from the piston 1111 extends into the internal space 131 and is connected to the flexible tube 13; the air filter 12 communicates with the internal space 131. It can be understood that the air filter 12 can communicate with the internal space 131 via a conduit.

[0047] In this invention, the flexible tube 13 is mounted on the injection tube 112. The end of the push rod 111 away from the piston 1111 extends into the internal space 131 and is connected to the flexible tube 13. The air filter 12 is connected to the internal space 131. Pressing the flexible tube 13 moves the push rod 111, which in turn moves the piston 1111 within the inner hole 1121 of the injection tube 112. This allows the syringe 11 to draw or push liquid or gas. The flexible tube 13 protects the push rod 111, preventing contamination of the syringe 11 and liquid caused by hand contact with the push rod 111, thus ensuring the safety of the injection device 1. Furthermore, it ensures a sterile environment and improves dispensing accuracy and precision by precisely controlling the push rod 111 to dispense liquids with high precision.

[0048] In addition, during the compression of the flexible tube 13, external gas can enter the internal space 131 through the air filter 12. The air filter 12 can ensure that the gas entering the internal space 131 is sterile gas and will not contaminate the liquid or gas in the inner hole 1121, thus ensuring that the pipeline is in a sterile environment. Moreover, when the push rod 111 drives the piston 1111 to push towards the injection port, the air filter 12 can balance the air pressure in the internal space 131, reduce the resistance encountered by the push rod 111 during its movement, facilitate the push rod 111, and ensure the accuracy of the push rod 111's movement.

[0049] In one embodiment, such as Figure 1 and Figure 2 As shown, the injection device 1 further includes a sleeve 14, which is sleeved onto the injection tube 112, and the flexible tube 13 is sleeved onto the sleeve 14. Understandably, the flexible tube 13 is mounted on the injection tube 112 via the sleeve 14, and the sleeve 14 and the injection tube 112 can be connected by fasteners such as bolts or screws. Alternatively, the flexible tube 13 and the sleeve 14 can be connected by adhesive bonding or other methods. In this embodiment, the sleeve 14 serves to connect the flexible tube 13 and the injection tube 112, improving the ease of assembly of the injection device 1.

[0050] In one embodiment, such as Figure 2As shown, the injection tube 112 is further provided with a flange 1122, the flange 1122 is provided with a first mounting hole, and the sleeve 14 is provided with a second mounting hole. The sleeve 14 is fitted onto the injection tube 112 by fasteners (screws, bolts, etc.) inserted into the first mounting hole and the second mounting hole. Understandably, the flange 1122 is bent outwards towards the injection tube 112, and the sleeve 14 is fitted onto the injection tube 112 and abuts against the flange 1122. The tight connection between the flange 1122 and the sleeve 14 improves the stability of the sleeve 14 fitted onto the injection tube 112.

[0051] In one embodiment, the design of the injection tube having a first mounting hole can also be integrally molded, and the first mounting hole can be connected to the air filter, thereby reducing the installation process.

[0052] In one embodiment, such as Figure 1 and Figure 2 As shown, the flexible tube 13 is also provided with an insertion groove 132 communicating with the internal space 131. The end of the push rod 111 away from the piston 1111 is provided with an insertion part 1112, which is inserted into the insertion groove 132. Understandably, during the pressing of the flexible tube 13, the flexible tube 13 drives the push rod 111 to move through the insertion part 1112 inserted into the insertion groove 132, ensuring the smoothness of the movement of the push rod 111 by the flexible tube 13.

[0053] like Figure 3 As shown, the second embodiment of the present invention provides a dispensing device, including an injection three-way valve 2, a plurality of dispensing three-way valves 6, a plurality of dispensing conduits 7, and the aforementioned injection device 1; it can be understood that the number of dispensing three-way valves 6 and the number of dispensing conduits 7 are equal, and the number of dispensing three-way valves 6 and the number of dispensing conduits 7 can be set according to actual needs.

[0054] The first port of the injection three-way valve 2 is connected to the inner hole 1121, the second port of the injection three-way valve 2 is connected to the first port of the dispensing three-way valve 6, and the third port of the dispensing three-way valve 6 is connected to the dispensing conduit 7 in a one-to-one correspondence; between two adjacent dispensing three-way valves 6, the second port of one dispensing three-way valve 6 is connected to the first port of the other dispensing three-way valve 6; the third port of the injection three-way valve 2 is used to connect to the external bag to be dispensed. It can be understood that the injection three-way valve 2 can control the on / off state of its first port, second port, and third port, and the dispensing three-way valve 6 can control the on / off state of its first port, second port, and third port; the external bag to be dispensed can store cell fluid, etc.

[0055] Specifically, the injection three-way valve 2 controls its first and third interfaces to be in a connected state, and its first and second interfaces to be in a closed state. The push rod 111 is pulled by the flexible tube 13, and the push rod 111 moves the piston 1111, drawing liquid from the external bag to be dispensed into the inner hole 1121. The injection three-way valve 2 controls its first and second interfaces to be in a connected state, and its first and third interfaces to be in a closed state. The first, second, and third interfaces of the dispensing three-way valve 6 are all in a connected state, and the dispensing three-way valve 6 can be connected to the dispensing conduit 7 through the second interface of the injection three-way valve 2. The push rod 111 is pushed by the flexible tube 13, and the push rod 111 moves the piston 1111, pushing the sample liquid in the inner hole 1121 into the storage bag connected to the dispensing conduit 7. In this invention, the dispensing device can dispense the sample liquid from the external dispensing bag into each storage bag, and the sample liquid is always in a closed pipeline, so there will be no accident of contamination of the sample liquid. Moreover, it can ensure a sterile environment. By precisely controlling the push rod 111, the liquid is dispensed with high precision, which improves the dispensing accuracy and precision rate.

[0056] In one embodiment, such as Figure 3 As shown, the dispensing device further includes a first filter 4 and a mixing three-way valve 3; the third port of the injection three-way valve 2 is connected to the first port of the mixing three-way valve 3, the second port of the mixing three-way valve 3 is connected to the first filter 4, and the third port of the mixing three-way valve 3 is used to connect to an external bag to be dispensed. Understandably, the mixing three-way valve 3 can control the on / off state between the first port, the second port, and the third port.

[0057] Specifically, the injection three-way valve 2, the dispensing three-way valve 6, and the mixing three-way valve 3 are used to control the pipeline between the inner bore 1121 and the dispensing conduit 7 to be in a conductive state, and the pipeline between the inner bore 1121 and the mixing three-way valve 3 to be in a closed state. Then, the flexible tube 13 pulls the push rod 111, and the syringe 11 can draw all the storage bags into a vacuum state. After all the storage bags are drawn into a vacuum state, the injection three-way valve 2, the dispensing three-way valve 6, and the mixing three-way valve 3 are used to control the pipeline between the inner bore 1121 and all the dispensing conduits 7 to be in a closed state, and control the pipeline between the inner bore 1121 and the first filter 4 to be in a conductive state. Then, the flexible tube 13 pushes the push rod 111, and the push rod 111 can discharge the gas in the inner bore 1121 through the first filter 4 into the external environment.

[0058] By controlling the pipeline between the mixing three-way valve 3 and the first filter 4 to be closed through the injection three-way valve 2, the dispensing three-way valve 6, and the mixing three-way valve 3, and controlling the pipeline between the inner hole 1121 and the external bag to be dispensed to be connected, and controlling the pipeline between the inner hole 1121 and all the dispensing conduits 7 to be closed, the syringe 11 can draw the sample liquid in the external bag to be dispensed into the inner hole 1121 by pulling the push rod 111 through the flexible tube 13; then, by controlling the pipeline between the injection three-way valve 2 and the mixing three-way valve 3 to be closed, and controlling the pipeline between the inner hole 1121 and the dispensing conduits 7 to be connected, the push rod 111 is pushed through the flexible tube 13, and the push rod 111 pushes the sample liquid in the inner hole 1121 into the storage bag. After the storage bag contains a sufficient amount of sample liquid, the third ports of all the dispensing three-way valves 6 are closed, and the inlet of the storage bag is sealed by heat sealing or other techniques, thereby completing the function of dispensing the sample liquid from the external dispensing bag into each storage bag.

[0059] In one embodiment, such as Figure 3 As shown, the dispensing device further includes a second filter 5 and a pressure sensor (not shown) detachably connected to the second filter 5; one end of the second filter 5 is connected to the dispensing conduit, and the other end is connected to the pressure sensor; the pressure sensor is used to detect the air pressure in the dispensing conduit 7. Understandably, the pressure sensor can detect the pressure of each storage bag or the air pressure of the entire dispensing conduit in real time to check the airtightness of the dispensing conduit and whether it is under negative pressure or a near-vacuum state, thereby ensuring that the syringe 11 can completely extract the gas from the storage bags, reducing the impact of introducing excess air bubbles during subsequent dispensing, and avoiding accidents caused by contamination of the sample liquid due to residual gas in the storage bags.

[0060] In addition, the pressure sensor can detect the pressure of each storage bag or the air pressure of the entire dispensing conduit in real time to check the airtightness of the dispensing conduit and whether it is in a negative pressure state or a vacuum state, thereby ensuring that the syringe 11 can completely extract the gas from the storage bag, reduce the influence of excess air bubbles introduced during subsequent dispensing, and avoid the accident of contamination of sample liquid caused by gas remaining in the storage bag.

[0061] In one embodiment, such as Figure 3As shown, the dispensing device also includes a second filter 5 and a pressure sensor (not shown) detachably connected to the second filter 5; the third port of the last dispensing three-way valve 6, located away from the injection three-way valve 2, is connected to the second filter 5; the pressure sensor is used to detect the air pressure in the dispensing conduit 7. Understandably, by connecting the pressure sensor to the second filter 5 and activating the first, second, and third ports of the dispensing three-way valve 6, the pressure sensor can detect the pressure of each storage bag in real time. Connecting the third port of the last dispensing three-way valve 6, located away from the injection three-way valve 2, to the second filter 5 is to more accurately determine the air pressure in the dispensing conduit. Setting it at the furthest end ensures the correctness and accuracy of pressure detection for all storage bags, thereby ensuring that the syringe 11 can completely extract the gas from the storage bags, reducing the impact of introducing excess air bubbles during subsequent dispensing, and avoiding contamination of the sample solution caused by residual gas in the storage bags.

[0062] In one embodiment, such as Figure 3 As shown, the dispensing device also includes a support plate 8, on which multiple clips 81 are provided, and the dispensing conduits 7 are inserted into the clips 81 one by one. Understandably, the dispensing conduits 7 being clipped into the clips 81 ensures that neither the dispensing conduits 7 nor the storage bag are on the support plate 8.

[0063] In one embodiment, such as Figure 3 As shown, the injection and dispensing device also includes a support plate 8, and both the injection three-way valve 2 and the dispensing three-way valve 6 can be detachably mounted on the support plate 8. It can be understood that the injection three-way valve 2 and the dispensing three-way valve 6 can be detachably mounted on the support plate 8 via a snap-fit ​​structure or similar means.

[0064] The third embodiment of the present invention provides a dispensing instrument, including the dispensing device described above.

[0065] like Figure 4 As shown, the fourth embodiment of the present invention provides a dispensing method applied to the above-described dispensing apparatus, characterized in that it includes:

[0066] S100: Control the flow direction of the injection three-way valve 2 and the push rod 111 of the injection device 1 to allow the sample liquid in the external bag to flow into the injection tube 112, and control the push rod 111 to stop when the preset capacity is reached; it can be understood that the preset capacity can be determined according to actual needs.

[0067] Specifically, by controlling the pipeline between the inner hole 1121 and the dispensing conduit 7 to be closed through the injection three-way valve 2, and controlling the pipeline between the inner hole 1121 and the external bag to be dispensed to be open, the push rod 111 is pulled by the flexible tube 13. The push rod 111 drives the piston 1111 to move and draw the sample liquid in the external bag to be dispensed into the inner hole 1121.

[0068] S200, switch the flow direction of the injection three-way valve 2 and the flow direction of each dispensing three-way valve 6, and push the push rod 111 of the injection device 1 to dispense the sample solution in the injection device 1 into the storage bags corresponding to each dispensing conduit 7.

[0069] Specifically, by controlling the tubing between the inner hole 1121 and the dispensing conduit 7 to be in a conductive state through the injection three-way valve 2, and controlling the tubing between the inner hole 1121 and the external dispensing bag to be in a closed state, the push rod 111 is pushed through the flexible tube 13. The push rod 111 drives the piston 1111 to move and push the sample liquid in the inner hole 1121 into the storage bag connected to the dispensing conduit 7. In this invention, the dispensing method can complete the dispensing of sample liquid from the external dispensing bag into various storage bags. The sample liquid is always in a closed tubing, preventing the accident of sample liquid contamination, and ensuring a sterile environment. By precisely controlling the push rod 111 to dispense liquid with high precision, the dispensing accuracy and precision are improved.

[0070] In one embodiment, such as Figure 1 As shown, before the flow direction of the injection three-way valve 2 and the push rod 111 of the injection device 1 are controlled to allow the sample liquid in the external bag to flow into the injection tube 112 (i.e., step S100), the procedure further includes:

[0071] S110, control the flow direction of the injection three-way valve 2 and the dispensing three-way valve 6, and control the push rod 111 of the injection device 1 to cause the syringe 11 to draw gas from each of the storage bags and discharge it.

[0072] Specifically, the injection three-way valve 2 and the dispensing three-way valve 6 control the flow between the inner bore 1121 and the dispensing conduit 7 to be open, and the flow between the inner bore 1121 and the mixing three-way valve 3 to be closed. Then, the flexible tube 13 pulls the push rod 111, allowing the syringe 11 to draw all storage bags into a near-vacuum state. After all storage bags are drawn into a near-vacuum state, the injection three-way valve 2 and the dispensing three-way valve 6 control the flow between the inner bore 1121 and all the dispensing conduits 7 to be closed, and control the flow between the inner bore 1121 and the third interface of the dispensing three-way valve 6 to be open. Then, the flexible tube 13 pushes the push rod 111, allowing the gas in the inner bore 1121 to be discharged into the external environment through the third interface of the injection three-way valve 2. Afterwards, the syringe 11 dispenses the sample liquid from the external dispensing bags into each storage bag. In this embodiment, the gas in the storage bag needs to be discharged through the injection device 1 before storing the sample liquid, thus ensuring the cleanliness of the storage bag.

[0073] In one embodiment, controlling the flow direction of the injection three-way valve 2 and the dispensing three-way valve 6, and controlling the push rod 111 of the injection device 1 to cause the syringe 11 to draw gas from each of the storage bags and discharge it (i.e., step S110), includes:

[0074] The third port of the injection three-way valve 2 is connected to the first port of the mixing three-way valve 3, the second port of the mixing three-way valve 3 is connected to the first filter 4, and the third port of the mixing three-way valve 3 is connected to the external bag to be dispensed.

[0075] S111. After controlling the pipeline between the first filter 4 and the inner hole 1121 to be closed and the pipeline between the inner hole 1121 and all the dispensing conduits 7 to be open through the injection three-way valve 2, the dispensing three-way valve 6 and the mixing three-way valve 3, the push rod 111 is controlled to put each storage bag into a near-vacuum state. It can be understood that the first and third ports of the injection three-way valve 2 are closed and the first and second ports of the injection three-way valve 2 are open. The first, second and third ports of the dispensing three-way valve 6 are all open. At this time, the pipeline between the first filter 4 and the inner hole 1121 is closed and the pipeline between the inner hole 1121 and all the dispensing conduits 7 is open. The near-vacuum state refers to a space state where the gas pressure is lower than one atmosphere.

[0076] S112. After controlling the pipeline between the inner bore 1121 and all the dispensing conduits 7 to be in a closed state through the injection three-way valve 2, the dispensing three-way valve 6, and the mixing three-way valve 3, and controlling the pipeline between the first filter 4 and the inner bore 1121 to be in a conductive state, the syringe 11 is controlled to discharge the gas in the inner bore 1121 through the first filter 4. It can be understood that when the first and second ports of the injection three-way valve 2 are closed, and the first and third ports of the injection three-way valve 2 are conductive, and the first, second, and third ports of the mixing three-way valve 3 are all conductive, the pipeline between the first filter 4 and the inner bore 1121 is conductive, and the pipeline between the inner bore 1121 and all the dispensing conduits 7 is closed.

[0077] Specifically, the injection three-way valve 2, the dispensing three-way valve 6, and the mixing three-way valve 3 are used to control the pipeline between the inner hole 1121 and the dispensing conduit 7 to be in a conductive state, and the pipeline between the inner hole 1121 and the mixing three-way valve 3 to be in a closed state. Then, the flexible tube 13 pulls the push rod 111, and the syringe 11 can draw all the storage bags into a near-vacuum state. After all the storage bags are drawn into a near-vacuum state, the injection three-way valve 2, the dispensing three-way valve 6, and the mixing three-way valve 3 are used to control the pipeline between the inner hole 1121 and all the dispensing conduits 7 to be in a closed state, and control the pipeline between the inner hole 1121 and the first filter 4 to be in a conductive state. Then, the flexible tube 13 pushes the push rod 111, and the push rod 111 can discharge the gas in the inner hole 1121 through the first filter 4 into the external environment. The near-vacuum state can also refer to a space state where the gas pressure is lower than a preset gas pressure value (less than atmospheric pressure).

[0078] By controlling the pipeline between the mixing three-way valve 3 and the first filter 4 to be closed through the injection three-way valve 2, the dispensing three-way valve 6, and the mixing three-way valve 3, and controlling the pipeline between the inner hole 1121 and the external bag to be dispensed to be connected, and controlling the pipeline between the inner hole 1121 and all the dispensing conduits 7 to be closed, the syringe 11 can draw the sample liquid in the external bag to be dispensed into the inner hole 1121 by pulling the push rod 111 through the flexible tube 13; then, controlling the pipeline between the injection three-way valve 2 and the mixing three-way valve 3 to be connected, and controlling the pipeline between the inner hole 1121 and the dispensing conduit 7 to be connected, the push rod 111 is pushed through the flexible tube 13, and the push rod 111 pushes the sample liquid in the inner hole 1121 into the storage bag. After the storage bag contains a sufficient amount of sample liquid, the third ports of all the dispensing three-way valves 6 are closed, and the inlet of the storage bag is sealed by heat sealing or other techniques, thereby completing the function of dispensing the sample liquid from the external dispensing bag into each storage bag.

[0079] In one embodiment, after controlling the conduit between the second filter 5 and the inner hole 1121 to be closed, and controlling the conduit between the inner hole 1121 and all the dispensing conduits 7 to be open, controlling the syringe 11 to bring each storage bag to a near-vacuum state (i.e., step S111) includes:

[0080] The third port of the dispensing three-way valve 6, located away from the injection three-way valve 2, is connected to the pressure sensor. Through the injection three-way valve 2, the dispensing three-way valve 6, and the mixing three-way valve 3, the pressure sensor is connected to all the dispensing conduits 7 and the inner bore 1121, and the pipeline between the pressure sensor and the inner bore 1121 is kept closed. Understandably, the end cap of the second filter 5 is opened, and the pressure sensor is connected to the second filter 5. The first, second, and third ports of all the dispensing three-way valves 6 are opened, so that the pressure sensor is connected to all the dispensing conduits 7 and the inner bore 1121.

[0081] The push rod 111 is controlled to extract gas from each external bag to be dispensed, and the pressure sensor is controlled to detect the pressure value of all the bags in real time. It can be understood that when the first port, the second port and the third port of all the dispensing three-way valves 6 are in the conducting state, all storage bags can share a pressure sensor, that is, one pressure sensor can detect the vacuum degree of all storage bags at the same time.

[0082] When the pressure value detected by the pressure sensor reaches a preset pressure value, it indicates that the syringe 11 has brought each of the storage bags to a near-vacuum state. Understandably, the preset pressure value can be set according to actual needs; when the pressure in the storage bag reaches the preset pressure, it indicates that the gas in the storage bag has been completely extracted. In this embodiment, the design of the pressure sensor ensures the cleanliness of the gas extracted from each storage bag by the syringe 11.

[0083] In one embodiment, after the sample solution in the injection device 1 is dispensed into the storage bags corresponding to each dispensing catheter 7 (i.e., after step S200), the method further includes:

[0084] After controlling the pipeline between the first filter 4 and the inner hole 1121 to be in a conductive state, the syringe 11 is controlled to draw external gas into the inner hole 1121 through the first filter 4. Understandably, after the second port of the injection three-way valve 2 is in a closed state, the first and third ports of the injection three-way valve 2 are in a conductive state, the first and second ports of the mixing three-way valve 3 are in a conductive state, and the third port of the mixing three-way valve 3 is in a closed state, the syringe 11 can draw external gas through the first filter 4.

[0085] After controlling the pipeline between the first filter 4 and the injection three-way valve 2 to be closed, and controlling the pipeline between all the dispensing catheters 7 and the inner hole 1121 to be open, the syringe 11 is controlled to push the air in the inner hole 1121 to each of the dispensing catheters 7, and the sensor is controlled to detect in real time whether there is sample liquid in the dispensing catheter 7; it can be understood that after closing the third port of the injection three-way valve 2, opening the first and second ports of the injection three-way valve 2, and opening the first, second, and third ports of the dispensing three-way valve 6, the syringe 11 gradually injects the gas in the inner hole 1121 into each storage bag, and the sensor can detect in real time whether there is sample liquid in the corresponding dispensing catheter 7. To further explain, since the refractive index of the sample liquid and the gas in the dispensing catheter 7 is different, the sensor can detect in real time whether there is sample liquid in the dispensing catheter 7.

[0086] When the sensor detects that there is no sample liquid in the dispensing catheter 7, all pipelines between the dispensing three-way valves 6 and the dispensing catheter 7 are closed. Understandably, when the sensor detects that there is no sample liquid in the dispensing catheter 7, it indicates that the syringe 11 has pushed all the sample liquid in the dispensing catheter 7 into the storage bag. At this time, the syringe 11 stops injecting gas into the dispensing catheter 7 and closes the third port of the dispensing three-way valve 6, making each dispensing catheter 7 an independent unit. This allows the inlet of the storage bag to be closed through processes such as heat sealing, and finally, the storage bag can be removed from the dispensing catheter 7. In this embodiment, the dispensing method can push all the sample liquid in the dispensing catheter 7 into the storage bag, avoiding liquid waste and contamination problems caused by residual sample liquid in the pipeline, ensuring accurate dispensing, avoiding the influence of air bubbles on the liquid in the storage bag, and ensuring the effectiveness, accuracy, and high precision of the dispensing.

[0087] The above are merely embodiments of the injection device, dispensing device, dispensing instrument, and dispensing method of the present invention, and are not intended to limit the present invention. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. An injection device, characterized in that, The device includes a syringe, an air filter, and a flexible tube with an internal space; the syringe includes a plunger and an injection tube with an inner hole, the plunger having a piston inserted into the inner hole; The flexible tube is mounted on the injection tube, and the end of the push rod away from the piston extends into the internal space and is connected to the flexible tube; the air filter is connected to the internal space.

2. The injection device according to claim 1, characterized in that, The injection device further includes a sleeve, which is fitted onto the injection tube, and the flexible tube is fitted onto the sleeve.

3. The injection device according to claim 2, characterized in that, The injection tube is also provided with a flange, the flange is provided with a first mounting hole, and the sleeve is provided with a second mounting hole. The sleeve is sleeved on the injection tube by fasteners inserted into the first mounting hole and the second mounting hole.

4. The injection device according to claim 1, characterized in that, The flexible tube is also provided with a plug-in groove that connects to the internal space, and the end of the push rod away from the piston is provided with a plug-in part, which is inserted into the plug-in groove.

5. A dispensing device, characterized in that, It includes an injection three-way valve, multiple dispensing three-way valves, multiple dispensing conduits, and an injection device as described in any one of claims 1 to 4; The first port of the injection three-way valve is connected to the inner hole, the second port of the injection three-way valve is connected to the first port of the dispensing three-way valve, and the third port of the dispensing three-way valve is connected to the dispensing conduit in a one-to-one correspondence; between two adjacent dispensing three-way valves, the second port of one dispensing three-way valve is connected to the first port of the other dispensing three-way valve; the third port of the injection three-way valve is used to connect to the external bag to be dispensed.

6. The dispensing device according to claim 5, characterized in that, The dispensing device also includes a first filter and a mixing three-way valve; The third port of the injection three-way valve is connected to the first port of the mixing three-way valve, the second port of the mixing three-way valve is connected to the first filter, and the third port of the mixing three-way valve is used to connect to an external bag to be dispensed.

7. The dispensing device according to claim 6, characterized in that, The dispensing device also includes a second filter and a pressure sensor detachably connected to the second filter; One end of the second filter is connected to the dispensing conduit, and the other end is connected to the pressure sensor; The pressure sensor is used to detect the air pressure in the dispensing conduit.

8. The dispensing device according to claim 7, characterized in that, The dispensing device further includes a support plate with multiple clips on it, and the dispensing conduits are inserted into the clips one by one; and / or The dispensing device also includes a support plate, and both the injection three-way valve and the dispensing three-way valve can be detachably mounted on the support plate.

9. A dispensing instrument, characterized in that, Includes the dispensing apparatus as described in any one of claims 5 to 8.

10. A dispensing method applied to the dispensing apparatus as described in any one of claims 5 to 8, characterized in that, include: Control the flow direction of the injection three-way valve and the push rod of the injection device to allow the sample liquid in the external bag to flow into the injection tube, and control the push rod to stop when the preset capacity is reached; Switch the flow direction of the injection three-way valve and the flow direction of each dispensing three-way valve, and push the push rod of the injection device to dispense the sample solution in the injection device into the storage bags corresponding to each dispensing catheter.

11. The packaging method according to claim 10, characterized in that, Before the flow direction of the injection three-way valve and the push rod of the injection device are controlled to allow the sample solution in the external dispensing bag to flow into the injection tube, the following additional steps are also included: Controlling the flow direction of the injection three-way valve and the dispensing three-way valve, and controlling the push rod of the injection device, causes the syringe to draw gas from each of the storage bags and discharge it.

12. The packaging method according to claim 11, characterized in that, The control of the flow direction of the injection three-way valve and the dispensing three-way valve, and the control of the plunger of the injection device to cause the syringe to draw gas from each of the storage bags and discharge it, includes: The third port of the injection three-way valve is connected to the first port of the mixing three-way valve, the second port of the mixing three-way valve is connected to the first filter, and the third port of the mixing three-way valve is connected to the external bag to be dispensed. After controlling the pipeline between the first filter and the inner hole to be closed and the pipeline between the inner hole and all the dispensing conduits to be open by the injection three-way valve, the dispensing three-way valve and the mixing three-way valve, the push rod is controlled to put each storage bag into a near-vacuum state. After controlling the pipeline between the inner hole and all the dispensing conduits to be closed by the injection three-way valve, the dispensing three-way valve and the mixing three-way valve, and controlling the pipeline between the first filter and the inner hole to be open, the syringe is controlled to discharge the gas in the inner hole through the first filter.

13. The packaging method according to claim 12, characterized in that, After controlling the tubing between the second filter and the inner bore to be closed, and controlling the tubing between the inner bore and all the dispensing conduits to be open, controlling the syringe to bring each storage bag into a near-vacuum state includes: Control the third port of the dispensing three-way valve, which is located away from the injection three-way valve, to connect to the pressure sensor; control the pressure sensor to connect to all the dispensing conduits and the inner hole through the injection three-way valve, the dispensing three-way valve, and the mixing three-way valve, and control the pipeline between the pressure sensor and the inner hole to be in a closed state; The push rod is controlled to extract gas from each external bag to be dispensed, and the pressure sensor is controlled to detect the pressure value of all the bags in real time. When the pressure value detected by the pressure sensor reaches the preset pressure value, it indicates that the syringe has put each of the storage bags into a near-vacuum state.

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