Flavored chewable tablet for old pets and production process of flavored chewable tablet

Abstract

The invention relates to flavored chewable tablets for old pets and a production process of the flavored chewable tablets. The preparation method comprises the following steps: respectively extracting sea-buckthorn, acanthopanax and semen cuscutae for at least one time to respectively obtain corresponding filtrate and filter residues, and respectively refrigerating the filtrate and the filter residues; the extraction treatment comprises smashing, ethanol presoaking and filtering; the preparation method comprises the following steps: cutting gynostemma pentaphyllum into pieces, pre-soaking with water, adding filter residues of sea-buckthorn, acanthopanax and semen cuscutae, and uniformly mixing to obtain a compound; boiling and filtering the compound at least once, and drying filtrate to obtain extract powder A; meanwhile, the sea-buckthorn, the acanthopanax and the semen cuscutae are uniformly mixed, decompressed and dried, and extract powder B is obtained; uniformly mixing the extract powder A, the extract powder B, mannitol, microcrystalline cellulose, sodium carboxymethyl starch, magnesium stearate, beef flavor powder and beef flavor essence, tabletting, and coating, so as to obtain the flavor chewable tablet for old pets to reduce abnormal unhairing phenomenon, enhance the body activity and improve the movement flexibility. The preparation method comprises the following steps: uniformly mixing the extract powder A, the extract powder B, mannitol, microcrystalline cellulose, sodium carboxymethyl starch, magnesium stearate, beef flavor powder and beef flavor essence;

Description

Technical Field

[0001] This application relates to the field of composition extraction technology, and more specifically, to a flavored chewable tablet for senior pets and its manufacturing process. Background Technology

[0002] With the upgrading of pet-keeping concepts and the gradual extension of pet lifespans, the health care needs of senior pets (generally referring to dogs over 8 years old, cats over 10 years old, or rodents over 18 months old) are becoming increasingly prominent. Senior pets, due to slowed metabolism and declining organ function, generally exhibit the following typical physiological characteristics: First, the skin and hair system degenerates, with insufficient nutrient supply to hair follicles leading to frequent abnormal hair loss, dry, brittle, and less lustrous hair. Simultaneously, skin elasticity weakens, making them prone to inflammatory problems such as erythema and dandruff. Second, motor function declines, with wear and tear on joint cartilage and muscle loss leading to reduced endurance. Climbing and running agility decreases significantly, and some senior pets even experience slow movement and limb stiffness. Third, the immune and metabolic systems weaken, with reduced liver and gallbladder metabolic efficiency and weakened kidney filtration function, easily causing metabolic disorders and further exacerbating health problems in the skin and motor systems. These physiological characteristics not only affect the quality of life of senior pets but also bring care challenges to pet owners. Therefore, developing products that can specifically improve the multidimensional health problems of senior pets has become a key focus of industry research. Currently, chewable tablets have become one of the mainstream dosage forms for health care products for senior pets due to their convenience and easily adjustable palatability. However, existing technologies still have significant shortcomings and are unable to meet actual needs. On the one hand, most chewable tablets are designed with compound ingredients of Western medicine. Although they can relieve single symptoms in the short term (such as improving hair through vitamin supplementation or relieving joint problems through chondroitin), the formula is complex and long-term feeding can easily cause metabolic burden on the liver and kidneys of pets, with the risk of side effects such as vomiting and diarrhea. They are especially unsuitable for older pets whose liver and kidney functions are already declining. On the other hand, some solutions attempt to use natural Chinese medicine ingredients to replace Western medicine in order to reduce the risk of side effects. However, existing Chinese medicine chewable tablets have two major problems: First, the selection of medicinal materials is limited and the cost is high. They rely heavily on precious Chinese medicinal materials such as Rehmannia glutinosa, Scutellaria baicalensis, and ginseng, resulting in high product prices and making it difficult to achieve large-scale promotion. Second, the efficacy is singular and lacks synergy. Existing Chinese medicine formulas often focus on a single problem (such as only protecting the kidneys or only protecting the hair) and are not designed to address the overall characteristics of "multi-system decline" in older pets. Furthermore, the extraction process leads to the loss of effective ingredients, resulting in poor improvement effects and failing to meet the multi-dimensional needs of older pets for skin health, mobility, and metabolic stability. Furthermore, existing chewable tablets generally neglect the palatability preferences and formulation stability requirements of elderly pets: elderly pets have decreased taste sensitivity and reduced appetite, and the bitter taste of traditional Chinese medicine ingredients can easily cause pets to refuse to eat. Existing solutions often simply add sweeteners to mask the odor, which has limited effect on improving palatability. At the same time, some effective components of traditional Chinese medicine (such as flavonoids and vitamins) are easily oxidized and degraded. Existing production processes lack targeted extraction and drying protection measures, resulting in short product shelf life and high loss rate of effective components during storage, further weakening the actual use effect. In summary, the current field of chewable tablets for senior pets urgently needs a technical solution that has controllable formulation costs, no risk of side effects, can improve the physiological functions of senior pets in multiple dimensions, and takes into account palatability and stability. The key direction for solving the above-mentioned technical pain points is to rationally select inexpensive and readily available traditional Chinese medicine compound formulas, optimize the extraction process to retain multiple effective ingredients, and combine excipient design to improve palatability and stability. Summary of the Invention

[0003] The purpose of this application is to overcome the above-mentioned technical problems and provide a flavored chewable tablet for senior pets and a manufacturing process thereof.

[0004] Firstly, a manufacturing process for flavored chewable tablets for senior pets, obtained by the following method: Extraction and refrigeration: Sea buckthorn, Acanthopanax senticosus, and Cuscuta chinensis were each extracted at least once to obtain corresponding filtrates and residues, which were then refrigerated. The extraction process included crushing, ethanol pre-soaking, and filtration. Mixing and drying: Gynostemma pentaphyllum is chopped, pre-soaked in water, and then Hippophae rhamnoides, Acanthopanax senticosus, and Cuscuta chinensis are added to obtain a filter residue. The residue is mixed evenly to obtain a complex. The complex is subjected to boiling and filtration at least once, and the filtrate is dried to obtain extract powder A. At the same time, Hippophae rhamnoides, Acanthopanax senticosus, and Cuscuta chinensis are mixed evenly, subjected to reduced pressure, and dried to obtain extract powder B. Mixing and tableting: Mix extract powder A, extract powder B, mannitol, microcrystalline cellulose, sodium carboxymethyl starch, magnesium stearate, beef flavor powder, and beef flavor essence evenly, compress, and coat to obtain flavored chewable tablets for senior pets.

[0005] By adopting the above technical solution, sea buckthorn, gynostemma pentaphyllum, eleutherococcus senticosus, and dodder each have different bioactive components. These components work synergistically in the composition to act on multiple physiological systems of aging pets, achieving synergistic effects.

[0006] The vitamin C and flavonoids in sea buckthorn have antioxidant properties, protecting skin cells from free radical damage. Acanthopanax senticosus glycosides in eleutherococcus senticosus enhance the skin's antioxidant capacity. Together, they promote skin health and reduce abnormal hair loss. The saponins in gynostemma pentaphyllum and eleutherococcus senticosus combat fatigue and enhance physical activity. The bioactive components in dodder seed optimize blood circulation efficiency. Together, they enhance physical activity and improve motor flexibility. The immunomodulatory components in gynostemma pentaphyllum and dodder seed enhance the function of the immune system. The vitamin C and flavonoids in sea buckthorn also have immunomodulatory effects. Together, they improve the immune system's function and enhance disease resistance. Sea buckthorn helps maintain normal hepatobiliary metabolism and supports stable kidney function. Eleutherococcus senticosus supports normal hepatobiliary metabolism, and dodder seed helps maintain blood sugar balance. Together, they maintain normal hepatobiliary metabolism and support stable kidney function.

[0007] Meanwhile, through specific extraction methods and preparation processes, the effective components of each raw material can be fully extracted and retained, ensuring maximum activity in the composition. Mannitol, as a sweetener and filler, improves palatability; microcrystalline cellulose and sodium carboxymethyl starch form a skeletal structure to control the sustained-release rate; beef flavoring masks the bitterness of the traditional Chinese medicine, improving pet compliance. Together with the various traditional Chinese medicine raw materials, they support the overall technical solution, achieving the goal of improving the physical condition of aged pets from multiple dimensions, and addressing the industry pain points of poor palatability, poor absorption, and low stability in pet traditional Chinese medicine preparations.

[0008] Preferably, the ethanol is prepared by the following method: in the extraction process, the purity of the ethanol is 75-95%, wherein the purity of the ethanol used for pre-soaking sea buckthorn and dodder is greater than that used for pre-soaking Acanthopanax senticosus.

[0009] By employing the above technical solutions, pre-soaking sea buckthorn and dodder seeds in ethanol with a purity of 75-95% (higher than that used for pre-soaking Acanthopanax senticosus) can efficiently extract the active ingredients from them, ensuring their activity in the composition. This helps maintain normal metabolism in the hepatobiliary system, supports stable kidney function, promotes skin health, reduces abnormal hair loss, enhances physical activity, improves motor flexibility, enhances immune system function, strengthens disease resistance, optimizes blood circulation efficiency, and helps maintain blood sugar balance. Similarly, pre-soaking Acanthopanax senticosus in ethanol with a purity of 75-95% (lower than that used for pre-soaking sea buckthorn and dodder seeds) can efficiently extract the active ingredients from it, ensuring their activity in the composition. This can enhance physical activity, improve motor flexibility, and support normal metabolism in the hepatobiliary system.

[0010] Preferably, the ethanol pre-soaking time is ≤3h.

[0011] By adopting the above technical solution, the ethanol pre-soaking time is limited to no more than 3 hours, which can complete the pre-soaking within a reasonable time and fully extract the effective components in sea buckthorn, Acanthopanax senticosus, and Cuscuta chinensis. Combined with the synergistic effects of sea buckthorn, Gynostemma pentaphyllum, Acanthopanax senticosus, and Cuscuta chinensis, it can promote the skin health of older pets, reduce abnormal hair loss, enhance physical activity and improve mobility, improve immune system function and disease resistance, maintain normal metabolism of the hepatobiliary system and support stable kidney function, while avoiding the loss of components or other adverse effects that may be caused by excessive soaking time.

[0012] Preferably, the extraction process of Acanthopanax senticosus and Cuscuta chinensis further includes heating and reflux for ≤1.5h, followed by filtration; the extraction process of Hippophae rhamnoides further includes ultrasonic dispersion for <1h, at a temperature ≤50℃.

[0013] By adopting the above technical solutions, the extraction process of Acanthopanax senticosus and Cuscuta chinensis involves heating and reflux for ≤1.5h followed by filtration, which can fully release the saponin components in Acanthopanax senticosus and efficiently extract the effective components in Cuscuta chinensis. In the extraction process of Hippophae rhamnoides, ultrasonic dispersion treatment at a temperature ≤50℃ and a time <1h can efficiently dissolve the flavonoids and fat-soluble vitamins in Hippophae rhamnoides. Combined with the processing of raw materials and the processes of mixing, drying and flake formation, the effective components of Hippophae rhamnoides, Acanthopanax senticosus, Gynostemma pentaphyllum, and Cuscuta chinensis can be fully extracted and retained. These components work synergistically to promote the skin health of aging pets, reduce abnormal hair loss, enhance physical activity and improve mobility, improve immune system function and disease resistance, maintain normal metabolism of the hepatobiliary system, and support stable kidney function.

[0014] Preferably, the pre-soaking time of the Gynostemma pentaphyllum is ≤1.0h.

[0015] By adopting the above technical solution, the pre-soaking time of Gynostemma pentaphyllum can be controlled within 1.0 hour, which can be combined with the extraction and processing of raw materials such as sea buckthorn, Acanthopanax senticosus, and Cuscuta chinensis. In conjunction with subsequent mixing, drying, and slicing steps, the effective components of each raw material can be fully extracted, which can synergistically promote skin health, reduce abnormal hair loss, enhance physical activity and improve motor flexibility, improve immune system function and enhance disease resistance, maintain normal metabolism of the hepatobiliary system, and support stable kidney function.

[0016] Preferably, the boiling and heat preservation time in the boiling and filtration treatment of Gynostemma pentaphyllum is ≤1.5h.

[0017] By adopting the above technical solution, the effective components of Gynostemma pentaphyllum can be fully extracted. Combined with the effects of sea buckthorn, Acanthopanax senticosus, and Cuscuta chinensis, it can promote the skin health of older pets, reduce abnormal hair loss, enhance physical activity and improve mobility, improve immune system function and disease resistance, maintain normal metabolism of the liver and gallbladder system, and support stable kidney function. At the same time, it avoids the loss of effective components due to prolonged boiling, thus ensuring the efficacy of the chewable tablets.

[0018] Preferably, the drying temperature is less than 60°C.

[0019] By employing the above-mentioned technical solutions, flavored chewable tablets for senior pets are prepared through extraction, mixing, drying, blending, and tableting of sea buckthorn, eleutherococcus senticosus, dodder seed, and gynostemma pentaphyllum. These tablets can regulate the metabolic function of senior pets, promote skin health, reduce abnormal hair loss, enhance physical activity and mobility, improve immune system function and disease resistance, maintain normal liver and gallbladder metabolism, and support stable kidney function. Controlling the drying temperature to below 60℃ can reduce the degradation of heat-sensitive substances such as flavonoids and vitamins, strengthen the effect of the preparation process, and better preserve the active ingredients.

[0020] Preferably, the weight ratio is: sea buckthorn ≦ dodder < gynostemma pentaphyllum ≦ eleutherococcus senticosus.

[0021] By adopting the above technical solutions, the reasonable weight ratio can enable sea buckthorn, gynostemma pentaphyllum, eleutherococcus senticosus, and cuscuta chinensis to better exert their synergistic effects, further promote skin health, reduce abnormal hair loss, enhance physical activity and improve motor flexibility, improve immune system function and enhance disease resistance, maintain normal metabolism of the hepatobiliary system, and support stable kidney function.

[0022] Preferably, based on the total weight of extract powder A and extract powder B, the following raw materials are used in the following amounts: mannitol ≦20wt%, microcrystalline cellulose ≦2wt%, sodium carboxymethyl starch ≦1wt%, magnesium stearate ≦0.5wt%, beef flavor powder ≦3wt%, and beef flavor essence ≦0.3wt%.

[0023] By adopting the above technical solution, sea buckthorn, eleutherococcus senticosus, and dodder seed are extracted by crushing, pre-soaking in ethanol, and filtering, and then refrigerated. Gynostemma pentaphyllum is chopped, pre-soaked in water, and then added to the filter residue of the three extracts and mixed. The complex is boiled, filtered, and the filtrate is vacuum dried to obtain extract powder A. The three extracts are mixed and dried under reduced pressure to obtain extract powder B. Then, extract powder A, extract powder B, mannitol, microcrystalline cellulose, sodium carboxymethyl starch, magnesium stearate, beef flavor powder, and beef flavor essence are added according to the total weight of extract powder A and extract powder B, with mannitol ≤20wt%, microcrystalline cellulose ≤2wt%, sodium carboxymethyl starch ≤2wt%, and magnesium stearate ≤2wt%. A chewable tablet is prepared by mixing and coating sodium carboxymethyl starch (≤1 wt%), magnesium stearate (≤0.5 wt%), beef flavor powder (≤3 wt%), and beef flavoring (≤0.3 wt%). This product can promote skin health in older pets, reduce abnormal hair loss, enhance physical activity and improve mobility, improve immune system function and disease resistance, maintain normal metabolism in the hepatobiliary system, support stable kidney function, improve palatability with mannitol, control the sustained-release rate with microcrystalline cellulose and sodium carboxymethyl starch, and mask the bitterness of the traditional Chinese medicine with beef flavoring to improve pet compliance.

[0024] Secondly, a flavored chewable tablet for senior pets, obtained by a manufacturing process for flavored chewable tablets for senior pets.

[0025] By adopting the above technical solutions, we can promote the skin health of aging pets and reduce abnormal hair loss; enhance physical activity and improve mobility; improve immune system function and disease resistance; maintain normal metabolism of the hepatobiliary system and support stable kidney function; and ensure that the effective components of each raw material are fully extracted and retained by controlling the purity of ethanol, soaking time, heating reflux time, ultrasonic dispersion treatment time and temperature, Gynostemma pentaphyllum pre-soaking time and boiling and heat preservation time, drying temperature, raw material weight ratio and dosage, etc., thereby improving the palatability and stability of chewable tablets and reducing the loss of heat-sensitive components.

[0026] In summary, this application includes at least one of the following beneficial technical effects: 1. The compound of sea buckthorn, Acanthopanax senticosus, Gynostemma pentaphyllum, and Cuscuta chinensis has a synergistic effect, promoting skin health, reducing abnormal hair loss, enhancing physical activity, and improving motor flexibility; 2. The immunomodulatory components of Gynostemma pentaphyllum, Cuscuta chinensis, and Hippophae rhamnoides work together to improve the function of the immune system and enhance disease resistance; 3. Extraction methods such as ethanol pre-soaking, water pre-soaking, heating reflux, and ultrasonic dispersion are adopted, combined with measures such as vacuum drying and controlled drying temperature to retain the activity of effective ingredients. At the same time, excipients such as mannitol and beef flavor powder are added to balance the palatability and stability of the product and reduce the loss of effective ingredients during storage. Detailed Implementation

[0027] The present application will be further described in detail below with reference to the embodiments. Example

[0028] Example 1 A flavored chewable tablet for senior pets is prepared by the following method: Extraction and refrigeration: Take 2.0 kg of sea buckthorn (sea buckthorn fruit) and put it into a high-speed blender to crush it. Put it into a gauze bag and pre-soak it in 16,000 ml of 95% ethanol for 3 hours. Then disperse it by ultrasonic treatment at 50°C for 55 minutes. Then put it into a filter device and sieve it through 1000 mesh. Collect the filtrate and the filter residue. Add 15,000 ml of 95% ethanol to the filter residue again and disperse it by ultrasonic treatment at 50°C for 55 minutes. Put it into a filter device again and sieve it through 1000 mesh. Collect the filtrate and the filter residue. Combine the filtrates from the first two batches and store them in a refrigerator.

[0029] Take 2.2 kg of Acanthopanax senticosus and put it into a slicer. Slice the slices and pre-soak them in 25,000 ml of 75% ethanol for 3 hours. Heat the slices to 95°C and reflux for 1.5 hours. Then put the slices into a filter and sieve them through a 1000-mesh sieve. Collect the filtrate and the residue. Add 22,000 ml of 75% ethanol to the residue again, heat the residue to 95°C and reflux for 1.5 hours. Put the residue into a filter again and sieve it through a 1000-mesh sieve. Collect the filtrate. Combine the filtrates and store them in a refrigerator. Keep the residue for later use.

[0030] Take 2.0 kg of dodder seeds and put them into a high-speed blender to crush them. Place them in a gauze bag and pre-soak them in 26,000 ml of 95% ethanol for 3 hours. Heat the mixture to 95°C and reflux for 1.5 hours. Filter the mixture and collect the filtrate and residue. Add another 25,000 ml of 95% ethanol to the residue and heat it to reflux for 1.5 hours. Then put the residue into a filter and sieve it through a 1000-mesh sieve. Collect the filtrate. Combine the filtrates and store them in a refrigerator. Keep the residue for later use.

[0031] Mixing and drying: Take 2.2 kg of Gynostemma pentaphyllum and put it into a high-speed blender to crush it. Add 150,000 ml of water and soak for 1 hour. Then add sea buckthorn, Acanthopanax senticosus, and Cuscuta chinensis to obtain the filter residue and mix them evenly. Boil them together for 1.5 hours. Put them into a filter device and sieve them through 1000 mesh. Collect the filtrate and filter residue. Add 130,000 ml of water to the filter residue, heat to 100℃ and boil for 1.5 hours. Put it into a filter device and sieve it through 1000 mesh. Collect the filtrate. Combine the filtrates and dry them under vacuum at 60℃ to obtain dry extract powder A.

[0032] Meanwhile, the filtrates of sea buckthorn, Acanthopanax senticosus, and Cuscuta chinensis were mixed evenly, and the ethanol was recovered under reduced pressure at 50°C. Then, the mixture was dried under vacuum at 50°C to obtain dry extract powder, thus obtaining extract powder B.

[0033] Mixing and tableting: Mix all extract powder A and extract powder B evenly, weigh them, and then, based on the total weight of extract powder A and extract powder B, use the following amounts of raw materials as follows: 20wt% mannitol, 2wt% microcrystalline cellulose, 1wt% sodium carboxymethyl starch, 0.5wt% magnesium stearate, 3wt% beef flavor powder, and 0.3wt% beef flavor essence. Mix thoroughly and directly compress into tablets weighing 0.5g each. Coat the compressed tablets with a film and package them in a double layer using aluminum-plastic blister packs to obtain flavored chewable tablets for senior pets.

[0034] Comparative Example Comparative Example 1 The difference between Comparative Example 1 and Example 1 is that sea buckthorn is not added, and sea buckthorn is replaced with an equal amount of Gynostemma pentaphyllum.

[0035] Comparative Example 2 The difference between Comparative Example 2 and Example 1 is that Gynostemma pentaphyllum and Acanthopanax senticosus were replaced with Cuscuta chinensis in equal amounts.

[0036] Comparative Example 3 The difference between Comparative Example 3 and Example 1 is that Gynostemma pentaphyllum is not added, and an equal amount of Gynostemma pentaphyllum is replaced with Cuscuta chinensis.

[0037] Comparative Example 4 The difference between Comparative Example 4 and Example 1 is that Cuscuta chinensis is not added, and Cuscuta chinensis is replaced with an equal amount of Gynostemma pentaphyllum.

[0038] Comparative Example 5 The difference between Comparative Example 5 and Example 1 is that Acanthopanax senticosus is not added, and Acanthopanax senticosus is replaced with an equal amount of Hippophae rhamnoides.

[0039] Comparative Example 6 The difference between Comparative Example 6 and Example 1 is that Gynostemma pentaphyllum, Acanthopanax senticosus, and Cuscuta chinensis are all replaced with sea buckthorn in equal amounts.

[0040] Comparative Example 7 The difference between Comparative Example 7 and Example 1 is that: Gynostemma pentaphyllum, Acanthopanax senticosus, Cuscuta chinensis, and Hippophae rhamnoides were all mixed evenly before extraction. The specific process is as follows: Take 2.0 kg of sea buckthorn fruit, 2.2 kg of Acanthopanax senticosus, 2.0 kg of Cuscuta chinensis, and 2.2 kg of Gynostemma pentaphyllum and put them into a high-speed blender to crush them. Put them into a gauze bag and pre-soak them in 16,000 ml of 95% ethanol for 3 hours. Then disperse them by ultrasonic treatment at 50°C for 55 minutes. Then put them into a filter and sieve them through a 1000-mesh sieve. Collect the filtrate and the residue. Add 15,000 ml of 95% ethanol to the residue again and disperse it by ultrasonic treatment at 50°C for 55 minutes. Put it into a filter again and sieve it through a 1000-mesh sieve. Collect the filtrate and the residue. Combine the filtrates from the first two batches and store them in a refrigerator.

[0041] After recovering ethanol from the filter residue under reduced pressure at 50°C, it was then dried under vacuum at 50°C to obtain dry extract powder, thus obtaining extract powder B.

[0042] Performance testing The flavored chewable tablets for aged pets obtained in Example 1 and Comparative Examples 1-7 were used in the following experiments.

[0043] Experimental samples: 180 aged white mice (20 months old), half male and half female, weighing 28-35g, none of which had a history of skin disease or motor dysfunction, were grouped after 1 week of acclimatization. The animals were randomly divided into 9 groups using a randomized block design, with 20 animals in each group (10 males and 10 females). The drugs were administered according to body weight for 60 days. The blank group consisted of pet food that did not contain flavored chewable tablets for senior pets; Dosage conversion: Refer to the "Pet Drugs - Laboratory Animal Dosage Conversion Formula", and combine it with the mouse's weight (28-35g). Grind the chewable tablets into powder and mix them with a small amount of sterile feed at a dosage of 0.1g / kg body weight to make "medicated feed". Feeding frequency: Once a day, fixed between 9:00 and 10:00 am, to ensure that each group of mice completely consumes the medicated feed on the same day (the remaining medicated feed is weighed and recorded, and supplementary feeding is given if the mice do not consume it). Basic feeding: All groups were kept in the same SPF-grade environment (temperature 24℃, humidity 55%, 12h light and dark cycle), with free access to sterile drinking water and the same basic diet (without any added functional ingredients).

[0044] (a) Hair shedding detection (record once every 20 days, for a total of 3 times) Sampling method: The "standard area hair removal method" was used. A fixed area of ​​2cm×2cm was marked on the back of the mouse. The area was gently combed with a sterile comb to collect the shed hair. Hair loss quantity: The collected hair was weighed using an electronic balance (accuracy 0.001g) and converted to mg / 2cm². 2This yields the corresponding amount of shedding.

[0045] Abnormal hair loss rate: Observe the overall skin of the back and count the "sparse hair in certain areas (exposed area > 0.5cm)" 2 The number of mice with “abnormal hair loss” or “patchy hair loss” was counted, and the abnormal hair loss rate was calculated (number of abnormal mice / total number in the group × 100%). Judgment criteria: A: Shedding amount < 0.5 mg / 2 cm 2 Abnormal hair loss rate <5%; B: Shedding amount 0.5-1.0 mg / 2cm 2 Abnormal hair loss rate: 5%-10%; C: Shedding amount 0.5-1.0 mg / 2cm 2 Abnormal hair loss rate >10%; D: Shedding amount > 1.0 mg / 2 cm 2 Abnormal hair loss rate >15%.

[0046] (ii) Skin condition monitoring (recorded once every 20 days, for a total of 3 times) Observation indicators: Skin color: The L value (brightness) and a value (red-green tint) of a fixed area on the back (same as the hair loss detection area) were measured using a "skin color difference meter". The higher the L value, the more shiny the skin is, and the closer the a value is to 0, the less redness and swelling there is. Skin elasticity: The elasticity recovery rate of the back skin was measured using a "mini skin elasticity meter" (the degree of recovery within 10 seconds after pressing). A recovery rate >80% is considered normal. Skin inflammation: Observe for the appearance of erythema, scaling, and crusting, and calculate the incidence of inflammation (number of individuals with inflammation / total number in the group × 100%). Judgment criteria: A: L value > 65, a value -2 to 2, elasticity recovery rate > 90%, inflammation incidence rate < 3%; B: L value 60-65, a value 2-5 or -5 to -2, elasticity recovery rate 80.1%-90%, inflammation incidence rate >3%; C: L value 60-65, a value 2-5 or -5 to -2, elasticity recovery rate 70%-80%, inflammation incidence >10%; D: L value < 60, a value > 5 or < -5, elastic recovery rate < 70%, and inflammation incidence rate > 10%.

[0047] (III) Exercise monitoring (tested once every 20 days, for a total of 3 times) Test items: Autonomous activity distance: The total activity distance (unit: cm) of mice within 30 minutes was recorded using an "Animal Autonomous Activity Monitoring System" to reflect their overall activity capacity; Climbing ability: Construct a "vertical climbing frame" (50cm high, with a rough textured surface), record the time it takes for mice to climb from the bottom to the top (failure to reach the top in more than 30 seconds is considered a failure), and calculate the climbing success rate; Endurance test: An "animal treadmill" was used, with a speed of 8cm / s set, and the duration of continuous running by the mice was recorded (the test was considered complete if the mice did not restart within 10 seconds after stopping). Judgment criteria: A: 30-minute activity distance > 1500cm, climbing success rate > 90%, endurance time > 5min; B: 30-minute activity distance 1201-1500cm, climbing success rate 80%-90%, endurance time 3-5 minutes; C: 30-minute activity distance 1000-1200cm, climbing success rate 70%-79%, endurance time 3-5 minutes; D: 30-minute activity distance <1000cm, climbing success rate <70%, endurance time <3min.

[0048] The specific experimental data are shown in Table 1. Table 1. Experimental data for Example 1 and Comparative Examples 1-7 Based on Example 1 and Comparative Examples 1-6, and referring to Table 1, it can be seen that the hair removal, skin condition, and activity levels of Comparative Examples 1-6 are all at or above Grade B, while the hair removal, skin condition, and activity levels of Example 1 are all at or above Grade A. Therefore, the combination of sea buckthorn, gynostemma pentaphyllum, eleutherococcus senticosus, and cuscuta chinensis has a synergistic effect, further enhancing the overall performance of flavored chewable tablets for senior pets. It is suitable for senior pets, reduces abnormal hair loss, enhances physical activity, and improves mobility.

[0049] Based on Example 1 and Comparative Example 7, and in conjunction with Table 1, it can be seen that the hair removal, skin condition, and activity levels of Comparative Example 7 are all at or above Grade B, while the hair removal, skin condition, and activity levels of Example 1 are all at or above Grade A. This indicates that the co-process of this application has a better retention rate of effective ingredients, improving the overall effect of flavored chewable tablets for senior pets.

[0050] This specific embodiment is merely an explanation of this application and is not intended to limit it. After reading this specification, those skilled in the art can make modifications to this embodiment without contributing any inventive step, but such modifications are protected by patent law as long as they fall within the scope of the claims of this application.

Claims

1. A process for the production of a flavored chewable tablet for senior pets, characterized in that, Preparation method of the application is as follows: Extraction and refrigeration: the sea buckthorn, acanthopanax and cuscuta are extracted at least once to obtain filtrate and residue, respectively, and then refrigerated; the extraction includes crushing, ethanol pre-soaking and filtering; Mixing and drying: the gynostemma is cut, pre-soaked with water, and then mixed with sea buckthorn, acanthopanax and cuscuta to obtain residue, which is mixed evenly to obtain a compound; the compound is boiled at least once to obtain filtrate, which is dried to obtain extract powder A; at the same time, the filtrate of sea buckthorn, acanthopanax and cuscuta is mixed evenly, dried under reduced pressure to obtain extract powder B; Mixing and tabletting: the extract powder A, extract powder B, mannitol, microcrystalline cellulose, sodium carboxymethyl starch, magnesium stearate, beef flavor powder and beef flavor essence are mixed evenly, tabletted, coated to obtain the flavor chewable tablet for old pets.

2. A process for the production of a flavored chewable tablet for geriatric pets as claimed in claim 1 wherein: The extraction process is as follows: the purity of ethanol is 75-95%, and the purity of ethanol used for pre-soaking sea buckthorn and cuscuta is higher than that used for pre-soaking acanthopanax.

3. A process for the production of a flavored chewable tablet for geriatric pets as claimed in claim 2 wherein: The ethanol pre-soaking time is ≦3h.

4. A process for the production of a flavored chewable tablet for geriatric pets as claimed in claim 1 wherein: The extraction process of acanthopanax and cuscuta further includes heating refluxing ≦1.5h, and then filtering; the extraction process of sea buckthorn further includes ultrasonic dispersion treatment <1h at a temperature ≦50℃.

5. A process for the production of a flavored chewable tablet for geriatric pets as claimed in claim 1 wherein: The pre-soaking time of gynostemma is ≦1.0h.

6. A process for the production of a flavored chewable tablet for geriatric pets as claimed in claim 1 wherein: The boiling and holding time in the boiling and filtering process of gynostemma is ≦1.5h.

7. A process for the production of a palatable chewable tablet for geriatric pets as claimed in claim wherein: The drying temperature is less than 60℃.

8. A process for the production of a palatable chewable tablet for geriatric pets as claimed in claim, wherein, The weight ratio of sea buckthorn, cuscuta, gynostemma and acanthopanax is sea buckthorn ≦ cuscuta < gynostemma ≦ acanthopanax.

9. A process for the production of a palatable chewable tablet for geriatric pets according to claim, characterized by, The amount of the following raw materials is respectively: mannitol ≦20wt%, microcrystalline cellulose ≦2wt%, sodium carboxymethyl starch ≦1wt%, magnesium stearate ≦0.5wt%, beef flavor powder ≦3wt%, and beef flavor essence ≦0.3wt%, based on the total weight of extract powder A and extract powder B.

10. A flavored chew for senior pets, characterized in that, The application is obtained by a production process of the flavor chewable tablet for old pets.

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