Kidney-warming cold-dispelling uterus-warming ointment and application method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine external preparations, and discloses kidney-warming cold-dispelling uterus-warming ointment and an application method thereof. The kidney-warming cold-dispelling uterus-warming ointment is prepared from the following raw materials in parts by weight: 5 to 10 parts of cortex phellodendri, 8 to 12 parts of mantis egg-case, 10 to 15 parts of cortex eucommiae, 4 to 8 parts of deer-horn glue, 3 to 7 parts of fresh ocimum gratissimum, 8 to 12 parts of semen cuscutae, 2 to 6 parts of carbonized hair, 12 to 18 parts of natural beewax, 6 to 10 parts of hydrogenated soybean wax and 2 to 4 parts of glycerol. Through targeted compatibility of traditional Chinese medicines such as natural beeswax, cortex phellodendri, mantis egg-case and eucommia ulmoides, the transdermal absorption efficiency of active ingredients of the traditional Chinese medicines can be guaranteed, so that the traditional Chinese medicine components fully play a synergistic conditioning role in tonifying kidney and qi and warming kidney and uterus, and the external conditioning requirements of indications such as insufficiency of kidney-yang, uterus cold leucorrhea and the like are met.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of external use of traditional Chinese medicine, in particular to a kidney-warming and cold-dispelling palace paste and an application method thereof. BACKGROUND

[0002] Palace warming is an important direction of female reproductive health conditioning, and palace cold, as a common syndrome in women, is often manifested as cold pain in the lower abdomen, aversion to cold and cold limbs, irregular menstruation, dysmenorrhea, palace cold and other symptoms, and can even affect the reproductive function, causing significant impact on women's physical and mental health and quality of life. The core goal of palace warming is to improve the local blood circulation of the uterus, dispel the cold in the palace, and restore the normal physiological environment of the uterus. From the perspective of traditional Chinese medicine theory, palace warming and kidney-warming and cold-dispelling are closely related. The kidney is the root of life and the source of yang qi, and has the function of warming the viscera and promoting blood circulation. When the kidney yang is insufficient, the yang qi cannot warm the uterus, which is easy to cause the internal generation of cold and further cause palace cold related syndromes. Therefore, warming the kidney and dispelling the cold is the core logic of palace conditioning, and only by warming the kidney and dispelling the cold can the palace cold be improved from the root and the effect of warming the palace be achieved.

[0003] At present, the external conditioning products for warming the kidney and dispelling the cold to warm the palace mainly adopt the forms of paste and patch, and the implementation method is to select traditional Chinese medicine components with the effects of warming the kidney, dispelling the cold, promoting blood circulation and regulating menstruation, and then prepare external preparations by using vaseline, lanolin and other bases. The drug components are absorbed through skin patching to achieve local conditioning. However, in use, the traditional Chinese medicine components lack targeting, and the bases used cannot guarantee the transdermal absorption efficiency of the active components of traditional Chinese medicine, so that the traditional Chinese medicine components cannot fully play the synergistic conditioning role of tonifying the kidney and warming the palace, and cannot effectively meet the external conditioning needs of kidney yang deficiency, palace cold and other indications. SUMMARY

[0004] In view of the deficiencies of the prior art, the present application provides a kidney-warming and cold-dispelling palace paste and an application method thereof, which solves the problem that the traditional Chinese medicine components lack targeting and the bases used cannot guarantee the transdermal absorption efficiency of the active components of traditional Chinese medicine.

[0005] In the first aspect, the present application provides a kidney-warming and cold-dispelling palace paste, which comprises the following raw materials in parts by weight: Cortex Phellodendri 5-10 parts, Sangpaejiao 8-12 parts, Eucommia ulmoides 10-15 parts, Cornu Cervi Pantotrichum 4-8 parts, fresh Syzygium aromaticum and Ocimum basilicum 3-7 parts, Semen Cannabis 8-12 parts, Blood Charcoal 2-6 parts, natural beeswax 12-18 parts, hydrogenated soybean wax 6-10 parts, and glycerol 2-4 parts.

[0006] By adopting the technical scheme, the natural beeswax and the hydrogenated soybean wax are compounded, and the glycerol adjusts the extensibility and adhesion of the base, so that the paste can be stably attached to the skin surface and maintained for a suitable time period, and each patch can be used for 5-7 days, and the paste provides a carrier for the active components of the Chinese medicinal materials with the effects of tonifying kidney and benefiting qi, such as Chinese cork tree, egg case of mulberry snail and eucommia, to penetrate into the skin, so as to support the conditioning needs of the indications of kidney yang deficiency and palace cold and leukorrhagia.

[0007] In a second aspect, the application provides a preparation method of the paste for warming kidney and dispelling cold and warming uterus, comprising the following steps: S1, classification and processing of the Chinese medicinal materials: the Chinese medicinal materials to be crushed are crushed, sieved and mixed uniformly, fresh oregano is washed and prepared, and deer antler glue is crushed separately and prepared; S2, preparation of the Chinese medicinal extract: the mixed Chinese medicinal powder is extracted by water decoction, the extract is combined and concentrated to obtain a Chinese medicinal extract, and the fresh oregano is processed by juicing and mixed with the extract; S3, preparation of the plaster base: the natural beeswax and the hydrogenated soybean wax are heated and melted, and the glycerol is added and stirred uniformly to obtain a uniform plaster base; S4, mixing and forming of the paste: the Chinese medicinal extract is added to the plaster base and stirred uniformly, and the dissolved deer antler glue solution is added and continuously stirred until the paste is uniform; S5, pasting, adhering and cutting: the uniform paste is coated on a pure cotton pasting cloth, dried and cooled, and then cut into plaster patches of a preset size.

[0008] By adopting the technical scheme, the Chinese medicinal materials are classified and processed in S1, the Chinese medicinal materials to be crushed are crushed, sieved and mixed uniformly, the fresh oregano is washed and prepared, and the deer antler glue is crushed separately and prepared, which can adopt different processing methods according to the physical properties of different Chinese medicinal materials, avoid damage to the fresh oregano in the crushing process, and form a powder form of the deer antler glue for subsequent dissolution; In S2, the mixed Chinese medicinal powder is extracted by water decoction and concentrated to obtain a Chinese medicinal extract, and the fresh oregano is processed by juicing and mixed with the extract, which can extract the water-soluble components in the Chinese medicinal powder, and the juicing of the fresh oregano can avoid the destruction of volatile components in the high-temperature environment of water decoction, so that the water-soluble components and the volatile components coexist in the extract system; In S3, the natural beeswax and the hydrogenated soybean wax are heated and melted, and the glycerol is added and stirred uniformly to obtain a uniform plaster base, and the natural beeswax and the hydrogenated soybean wax can form a base structure with suitable transdermal properties, and the glycerol can adjust the extensibility and adhesion of the base; In step S4, the herbal extract is added to the plaster base and stirred until well mixed. Then, the dissolved deer antler glue solution is added and stirred until the plaster is uniform. This operation can ensure that the active ingredients in the herbal extract and the dissolved deer antler glue are evenly dispersed in the base, ensuring the consistency of the composition in all parts of the plaster. Step S5 involves uniformly applying the paste onto a pure cotton backing cloth, drying and cooling it, and then cutting it into plasters of the preset size. The pure cotton backing cloth can support the paste and adhere to the skin. The drying and cooling process allows the paste to solidify and take shape. The matrix, which is a blend of natural beeswax and hydrogenated soy wax, can maintain a stable shape after drying and cooling, and is not prone to cracking or sticking.

[0009] Preferably, in step S1, the specific operation of classifying and processing the Chinese herbal raw materials includes: the Chinese herbal raw materials to be pulverized are Phellodendron bark, Mantis egg case, Eucommia bark, Cuscuta seed, and carbonized human hair, which are pulverized separately and passed through a 60-100 mesh sieve, and then mixed evenly to obtain a fine powder of mixed Chinese herbal medicines; the deer antler glue is pulverized separately and passed through an 80-90 mesh sieve.

[0010] By adopting the above technical solution, the Chinese herbal raw materials to be pulverized are limited to Phellodendron bark, Mantis egg case, Eucommia bark, Cuscuta seed, and carbonized human hair. After pulverizing and sieving them separately, they are then mixed evenly to obtain a fine powder of mixed Chinese herbal medicines. This operation can avoid the problem of uneven particle size caused by differences in hardness and texture of different Chinese herbal raw materials, and ensure that the particle size of each raw material powder is consistent. This provides a particle size basis for the synchronous and full dissolution of water-soluble components of each raw material in the subsequent water decoction step. The separate pulverization and sieving of deer antler glue can achieve precise particle size control based on the physical properties of deer antler glue, so that its powder morphology is suitable for the subsequent water-water dissolution process requirements. This avoids the situation of substandard particle size when mixed and pulverized with other Chinese herbal raw materials, and ensures that the dissolved deer antler glue solution can be evenly dispersed in the paste. This classified pulverization and sieving treatment method can avoid the problem of insufficient dissolution of effective components due to improper raw material treatment, and provides a guarantee for retaining the water-soluble components in the raw materials in the subsequent extraction step.

[0011] Preferably, in step S2, the extraction step by decoction is as follows: Add the mixed Chinese herbal powder to 8-12 times its weight of purified water, decoct at a constant temperature of 60-80℃ for 1-2 hours, filter and collect the filtrate. Add 6-8 times the weight of purified water to the filter residue, boil once more, combine the two filtrates and concentrate to a herbal extract with a relative density of 1.1-1.3; The process of processing fresh clove basil juice and then mixing it with the extract includes the following steps: Crush fresh cloves and basil to extract the juice, filter it, and then mix it evenly with the above-mentioned Chinese herbal extract.

[0012] By adopting the above technical solution, purified water is added to the fine powder of traditional Chinese medicine and decocted at a constant temperature, so that the water-soluble components in the raw materials dissolve in the water and enter the filtrate. Repeated decoction of the filter residue can solve the problem of insufficient extraction of water-soluble components caused by single decoction. The two filtrates are combined and concentrated to form a traditional Chinese medicine extract, thus achieving the enrichment of water-soluble components. Fresh cloves and basil are juiced separately, filtered, and then mixed with the extract. This avoids the high temperature environment of water decoction from damaging the volatile components they contain, allowing the volatile components to be retained and coexist with the water-soluble components in the extract in the same system. This step-by-step extraction and separate juice-juicing combination process can avoid the loss of different types of effective components due to a single extraction method, providing a material basis for the synergistic effect of various components in the subsequent paste.

[0013] Preferably, step S2 further includes dissolving the gelatinous raw material, as follows: Add the pulverized deer antler glue to 5-8 times its weight of purified water, dissolve it in a water bath at 50-60℃, and stir until completely clear before use.

[0014] By adopting the above technical solution, and considering the component characteristics of deer antler glue, a water bath dissolution method can be used to avoid the destruction of the effective components of deer antler glue caused by direct heating. By adding purified water to the pulverized deer antler glue and stirring, the deer antler glue is gradually dissolved and forms a clear solution, ensuring that the effective components in the deer antler glue are fully dissolved and dispersed in the solution, avoiding the residue of undissolved solid particles. The dissolved deer antler glue solution can then be uniformly mixed with traditional Chinese medicine extracts and plaster bases.

[0015] Preferably, in step S3, the temperature during heating and melting is 65-75℃, and the stirring speed is 150-200 r / min; after adding glycerin, stirring is continued for 1-2 minutes to obtain a uniform plaster matrix.

[0016] By adopting the above technical solution, for the matrix formulation of natural beeswax and hydrogenated soy wax, heating and stirring are used to fully melt the natural beeswax and hydrogenated soy wax to form a homogeneous liquid mixture. After adding glycerin and continuing to stir, the glycerin can be evenly dispersed in the molten mixture, ultimately forming a homogeneous ointment matrix. This operation solves the problem of uneven dispersion of active ingredients caused by uneven mixing of matrix raw materials, and can provide a stable carrier base for subsequent ointment forming, making the final ointment less prone to cracking and adhesion.

[0017] Preferably, in step S4, adding the herbal extract to the plaster base and stirring to mix it thoroughly includes the following steps: Add the prepared herbal extract to the plaster matrix, maintain the temperature at 60-70℃, and stir for 2-3 minutes; Add the dissolved deer antler glue solution and continue stirring for 1-2 minutes to obtain a uniform plaster.

[0018] By adopting the above technical solution, after adding the herbal extract to the plaster matrix made of natural beeswax and hydrogenated soybean wax, the operation of stirring at a specific temperature can maintain the matrix in a suitable liquid state, providing environmental conditions for the uniform dispersion of water-soluble and volatile components in the herbal extract within the matrix. Subsequently, the addition of dissolved deer antler glue solution and continued stirring can further integrate the effective components of deer antler glue with the components of the herbal extract within the matrix, ultimately forming a uniform plaster. This step-by-step addition and stirring combination operation solves the problem of uneven dispersion of active ingredients with different properties in the matrix, providing a stable material basis for subsequent mounting, bonding, and cutting, and ensuring the structural stability of the plaster after molding.

[0019] Preferably, in step S5, applying the uniform paste onto the pure cotton backing cloth includes the following steps: Lay the pure cotton backing cloth flat, and evenly apply the plaster to the surface of the backing cloth with a coating thickness of 0.6-1.0mm; After coating, place the backing at 35-45℃ to dry for 20-30 minutes, cool to room temperature, and then cut into plasters of the preset size.

[0020] By employing the above technical solution, a uniform paste is evenly coated onto a flat, pure cotton backing cloth, ensuring consistent thickness across all parts of the paste and guaranteeing uniform release of the active ingredients during application. Drying the coated backing cloth at a specific temperature slowly removes excess moisture from the paste while maintaining the structural stability of the natural beeswax and hydrogenated soy wax matrix, preventing damage to volatile and water-soluble components due to excessively high drying temperatures. After drying and cooling to room temperature, the paste solidifies and takes shape. Cutting operations yield plasters of uniform specifications. The plasters are stable after drying and cooling, making them less prone to cracking or sticking together. The pure cotton backing cloth supports the paste and adheres to the skin, providing a carrier for transdermal absorption of the active ingredients.

[0021] Preferably, the drying process is carried out using natural ventilation, and the dried paste has no obvious bubbles and a smooth surface.

[0022] By adopting the above technical solution, natural ventilation is used during drying, which keeps the air circulation rate around the paste coated on the pure cotton backing cloth slow, allowing the moisture in the paste to evaporate slowly and evenly, avoiding the formation of air bubbles in the paste when the moisture escapes quickly, and ensuring that the surface of the paste gradually solidifies during the drying process, ultimately achieving a state where the paste has no obvious air bubbles and a smooth surface after drying.

[0023] Thirdly, this invention provides the application of the above-mentioned warming kidney and dispelling cold ointment, namely, its application in the preparation of medicines for treating kidney yang deficiency, cold uterus and irregular menstruation.

[0024] By adopting the above technical solution, the Kidney-Warming and Uterus-Cold-Dispelling Ointment is used to prepare medicines for treating kidney yang deficiency, uterine cold, and menstrual disorders. The active ingredients of traditional Chinese medicine such as Phellodendron bark, Mantis egg case, Eucommia bark, deer antler glue, fresh cloves, basil, Cuscuta seed, and human hair charcoal can work together to regulate the body. The matrix of natural beeswax and hydrogenated soybean wax can carry the active ingredients of traditional Chinese medicine and provide carrier conditions for their transdermal absorption, ensuring that the active ingredients of traditional Chinese medicine can penetrate into the body through the skin to exert their effects. After heating the product, apply it to the painful area. Each patch can be used for 5-7 days.

[0025] This invention provides a kidney-warming, cold-dispersing, and uterus-warming ointment and its application method. It has the following beneficial effects: 1. This invention uses natural beeswax in combination with targeted formulations of traditional Chinese medicines such as Phellodendron bark, Mantis egg case, and Eucommia bark to ensure the transdermal absorption efficiency of the active ingredients of the traditional Chinese medicines. This allows each component of the traditional Chinese medicines to fully exert its synergistic conditioning effects of tonifying the kidney and replenishing qi, warming the kidney and uterus, and is suitable for external conditioning needs of indications such as kidney yang deficiency, cold uterus and leukorrhea.

[0026] 2. This invention is based on the classification, crushing and sieving of Chinese herbal raw materials, step-by-step extraction by water decoction, and separate pounding of fresh cloves and basil to extract juice. It can specifically retain the volatile cold-dispelling components and water-soluble kidney-tonifying components in the raw materials, and avoid the loss or destruction of effective components due to improper processing methods, thus providing a solid material basis for the efficacy of the product.

[0027] 3. This invention utilizes a matrix formula of natural beeswax and hydrogenated soybean wax, along with natural ventilation and drying, to prevent the plaster from cracking or sticking together. It also has excellent skin compatibility, meeting the needs of long-term application. Attached Figure Description

[0028] Figure 1 This is a flowchart of the method of the present invention. Detailed Implementation

[0029] The technical solution of the present invention will now be clearly and completely described with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of them. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative effort are within the scope of protection of the present invention.

[0030] Example 1 This embodiment provides a kidney-warming, cold-dispelling, and uterus-warming ointment, comprising the following raw materials in parts by weight: 5 parts of Phellodendron bark, 8 parts of Mantis egg case, 10 parts of Eucommia bark, 4 parts of deer antler glue, 3 parts of fresh clove basil, 8 parts of dodder seed, 2 parts of human hair charcoal, 12 parts of natural beeswax, 6 parts of hydrogenated soybean wax, and 2 parts of glycerin. The preparation method of the above-mentioned kidney-warming, cold-dispelling, and uterus-warming ointment includes the following steps: S1. Classification and processing of Chinese herbal raw materials: Crush and sieve the Chinese herbal raw materials that need to be crushed separately and mix them evenly. Wash the fresh cloves and basil and set aside. Crush the deer antler glue separately and set aside. The specific operations for classifying and processing Chinese herbal raw materials include: the Chinese herbal raw materials that need to be pulverized are Phellodendron bark, mantis egg case, Eucommia bark, Cuscuta seed, and carbonized human hair. After pulverizing them separately, they are passed through a 60-mesh sieve and mixed evenly to obtain a fine powder of mixed Chinese herbal medicine. Deer antler glue is pulverized separately and passed through an 80-mesh sieve. S2. Preparation of Chinese herbal extract: The mixed fine powder of Chinese herbal medicine is extracted by decoction with water. The extracts are combined and concentrated to obtain Chinese herbal extract. Fresh cloves and basil are juiced and then mixed with the extract. The extraction steps by decoction are as follows: Add 8 times the weight of purified water to the mixed fine powder of traditional Chinese medicine, decoct at 60℃ for 1 hour, and collect the filtrate by filtration; add 6 times the weight of purified water to the residue, repeat the decoction once, combine the two filtrates, and concentrate to a traditional Chinese medicine extract with a relative density of 1.1; The process of mixing fresh clove basil juice with the extract includes the following steps: crush fresh clove basil juice, filter, and mix evenly with the above-mentioned traditional Chinese medicine extract; Simultaneously, step S2 also includes dissolving the gelatinous raw materials, as follows: add 5 times the weight of purified water to the prepared pulverized deer antler glue, dissolve in a water bath at 50℃, and stir until completely clear before use; S3. Preparation of plaster matrix: Heat and melt natural beeswax and hydrogenated soybean wax, add glycerin and stir evenly to obtain a uniform plaster matrix; During the heating and melting process, the temperature was 65℃ and the stirring speed was 150r / min; after adding glycerin, stirring was continued for 1min to obtain a uniform plaster matrix. S4. Mixing and shaping the paste: Add the Chinese herbal extract to the paste base and stir until well mixed. Then add the dissolved deer antler glue solution and continue stirring until the paste is uniform. The process of adding the Chinese herbal extract to the plaster matrix and stirring it includes the following steps: adding the prepared Chinese herbal extract to the plaster matrix, maintaining the temperature at 60°C, and stirring for 2 minutes; then adding the dissolved deer antler glue solution and continuing to stir for 1 minute to obtain a uniform plaster paste. S5. Mounting and Cutting: Apply a uniform paste to a pure cotton mounting cloth, and after drying and cooling, cut it into plasters of the preset size. The process of applying a uniform paste to a pure cotton backing cloth includes the following steps: the pure cotton backing cloth is laid flat, and the paste is evenly applied to the surface of the backing cloth with a thickness of 0.6 mm; the coated backing cloth is placed at 35°C to dry for 20 minutes, and after cooling to room temperature, it is cut into plaster patches of the preset size; during drying, natural ventilation is used, and after drying, the paste has no obvious bubbles and the surface is smooth.

[0031] Example 2 This embodiment provides a kidney-warming, cold-dispelling, and uterus-warming ointment, comprising the following raw materials in parts by weight: 8 parts of Phellodendron bark, 10 parts of Mantis egg case, 12 parts of Eucommia bark, 6 parts of deer antler glue, 5 parts of fresh clove basil, 10 parts of dodder seed, 4 parts of human hair charcoal, 15 parts of natural beeswax, 8 parts of hydrogenated soybean wax, and 3 parts of glycerin. The preparation method of the above-mentioned kidney-warming, cold-dispelling, and uterus-warming ointment includes the following steps: S1. Classification and processing of Chinese herbal raw materials: Crush and sieve the Chinese herbal raw materials that need to be crushed separately and mix them evenly. Wash the fresh cloves and basil and set aside. Crush the deer antler glue separately and set aside. The specific operations for classifying and processing Chinese herbal raw materials include: the Chinese herbal raw materials that need to be pulverized are Phellodendron bark, mantis egg case, Eucommia bark, Cuscuta seed, and carbonized human hair. They are pulverized separately and passed through an 80-mesh sieve. They are then mixed evenly to obtain a fine powder of mixed Chinese herbal medicine. Deer antler glue is pulverized separately and passed through an 85-mesh sieve. S2. Preparation of Chinese herbal extract: The mixed fine powder of Chinese herbal medicine is extracted by decoction with water. The extracts are combined and concentrated to obtain Chinese herbal extract. Fresh cloves and basil are juiced and then mixed with the extract. The extraction steps by water decoction are as follows: Add 10 times the weight of purified water to the mixed fine powder of traditional Chinese medicine, decoct at 70℃ for 1.5 hours, filter and collect the filtrate; add 7 times the weight of purified water to the residue, repeat the decoction once, combine the two filtrates and concentrate to a traditional Chinese medicine extract with a relative density of 1.2; The process of mixing fresh clove basil juice with the extract includes the following steps: crush fresh clove basil juice, filter, and mix evenly with the above-mentioned traditional Chinese medicine extract; Simultaneously, step S2 also includes dissolving the gelatinous raw materials, as follows: add 6.5 times the weight of purified water to the prepared pulverized deer antler glue, dissolve in a water bath at 55℃, stir until completely clear, and set aside. S3. Preparation of plaster matrix: Heat and melt natural beeswax and hydrogenated soybean wax, add glycerin and stir evenly to obtain a uniform plaster matrix; During the heating and melting process, the temperature was 70℃ and the stirring speed was 175 r / min; after adding glycerin, stirring was continued for 1.5 min to obtain a uniform plaster matrix. S4. Mixing and shaping the paste: Add the Chinese herbal extract to the paste base and stir until well mixed. Then add the dissolved deer antler glue solution and continue stirring until the paste is uniform. The process of adding the herbal extract to the plaster matrix and stirring it includes the following steps: adding the prepared herbal extract to the plaster matrix, maintaining the temperature at 65°C, and stirring for 2.5 minutes; then adding the dissolved deer antler glue solution and continuing to stir for 1.5 minutes to obtain a uniform plaster paste. S5. Mounting and Cutting: Apply a uniform paste to a pure cotton mounting cloth, and after drying and cooling, cut it into plasters of the preset size. The process of applying a uniform paste to a pure cotton backing cloth includes the following steps: the pure cotton backing cloth is laid flat, and the paste is evenly applied to the surface of the backing cloth with a thickness of 0.8 mm; the coated backing cloth is dried at 40°C for 25 minutes, cooled to room temperature, and then cut into plaster patches of the preset size; during drying, natural ventilation is used, and the paste has no obvious bubbles and a smooth surface after drying.

[0032] Example 3 This embodiment provides a kidney-warming, cold-dispelling, and uterus-warming ointment, comprising the following raw materials in parts by weight: 10 parts of Phellodendron bark, 12 parts of mantis egg case, 15 parts of Eucommia bark, 8 parts of deer antler glue, 7 parts of fresh clove basil, 12 parts of dodder seed, 6 parts of human hair charcoal, 18 parts of natural beeswax, 10 parts of hydrogenated soybean wax, and 4 parts of glycerin. The preparation method of the above-mentioned kidney-warming, cold-dispelling, and uterus-warming ointment includes the following steps: S1. Classification and processing of Chinese herbal raw materials: Crush and sieve the Chinese herbal raw materials that need to be crushed separately and mix them evenly. Wash the fresh cloves and basil and set aside. Crush the deer antler glue separately and set aside. The specific operations for classifying and processing Chinese herbal raw materials include: the Chinese herbal raw materials that need to be pulverized are Phellodendron bark, mantis egg case, Eucommia bark, Cuscuta seed, and carbonized human hair. After pulverizing them separately, they are passed through a 100-mesh sieve and mixed evenly to obtain a fine powder of mixed Chinese herbal medicine. Deer antler glue is pulverized separately and passed through a 90-mesh sieve. S2. Preparation of Chinese herbal extract: The mixed fine powder of Chinese herbal medicine is extracted by decoction with water. The extracts are combined and concentrated to obtain Chinese herbal extract. Fresh cloves and basil are juiced and then mixed with the extract. The extraction steps by water decoction are as follows: Add 12 times the weight of purified water to the mixed Chinese herbal powder, decoct at 80℃ for 2 hours, filter and collect the filtrate; add 8 times the weight of purified water to the residue, repeat the decoction once, combine the two filtrates and concentrate to a Chinese herbal extract with a relative density of 1.3; the process of mixing fresh clove basil juice with the extract includes the following steps: crush fresh clove basil juice, filter and mix it evenly with the above Chinese herbal extract; at the same time, step S2 also includes dissolving the gelatinous raw materials, the steps are as follows: add 8 times the weight of purified water to the prepared pulverized deer antler glue, dissolve it in a water bath at 60℃, stir until completely clear and set aside; S3. Preparation of plaster matrix: Heat and melt natural beeswax and hydrogenated soybean wax, add glycerin and stir evenly to obtain a uniform plaster matrix; During the heating and melting process, the temperature was 75℃ and the stirring speed was 200r / min; after adding glycerin, stirring was continued for 2 minutes to obtain a uniform plaster matrix. S4. Mixing and shaping the paste: Add the Chinese herbal extract to the paste base and stir until well mixed. Then add the dissolved deer antler glue solution and continue stirring until the paste is uniform. The process of adding the Chinese herbal extract to the plaster base and stirring it includes the following steps: adding the prepared Chinese herbal extract to the plaster base, maintaining the temperature at 70°C, and stirring for 3 minutes; then adding the dissolved deer antler glue solution and continuing to stir for 2 minutes to obtain a uniform plaster paste. S5. Mounting and Cutting: Apply a uniform paste to a pure cotton mounting cloth, and after drying and cooling, cut it into plasters of the preset size. The process of applying a uniform paste to a pure cotton backing cloth includes the following steps: the pure cotton backing cloth is laid flat, and the paste is evenly applied to the surface of the backing cloth with a thickness of 1.0 mm; the coated backing cloth is dried at 45°C for 30 minutes, cooled to room temperature, and then cut into plaster patches of the preset size; during drying, natural ventilation is used, and the paste has no obvious bubbles and a smooth surface after drying.

[0033] Comparative Example 1 The only difference from Example 2 is that the mantis egg case is missing.

[0034] Comparative Example 2 The only difference from Example 2 is that dried clove basil is used instead of fresh clove basil.

[0035] Comparative Example 3 The only difference from Example 2 is that paraffin wax is used instead of natural beeswax as the base material.

[0036] Comparative Example 4 The only difference from Example 2 is that in step S3, the temperature during heating and melting is 55°C.

[0037] Experiment 1: Detection of the effects of warming the kidneys and dispelling cold in rats with a cold uterus model This experiment used the warming kidney and dispelling cold ointment prepared in Examples 1-3 and Comparative Examples 1-4 as test samples, and blank pure cotton backing cloth as a blank control group. The experimental method followed the standard for constructing a uterine cold model in "Methodology of Pharmacological Research of Traditional Chinese Medicine": Eighty healthy female SD rats were randomly divided into 8 groups of 10 each. Except for the blank control group, the other 7 groups were fed with ice water via gavage and kept in a low-temperature environment of 4℃ for 7 consecutive days to construct a uterine cold model. After successful modeling, the abdomens of rats in each test group were shaved and disinfected. The corresponding sample was heated to 40℃ and applied to the Guanyuan acupoint on the abdomen for 5 days. The blank control group was treated with blank backing cloth. Rectal temperature of rats was measured before application, on day 3, and on day 5. Serum was collected after application, and the levels of prostaglandin E2 and estradiol in the serum were detected using enzyme-linked immunosorbent assay (ELISA).

[0038] Experiment 2: Detection of Dissolution Rate of Core Active Ingredients This experiment used samples prepared in Examples 1-3 and Comparative Examples 1-4 to detect the dissolution rate of key active ingredients for warming the kidneys and dispelling cold. The experimental method followed the dissolution determination method of Part IV of the 2020 edition of the Pharmacopoeia of the People's Republic of China. Artificial skin permeate was used as the dissolution medium. 0.5g (by weight of the ointment) of each sample was placed in a dissolution vessel. 5mL samples were taken at 1h, 3h, and 5h of dissolution. After filtration through a 0.45μm filter membrane, the contents of eugenol and chlorogenic acid in the filtrate were detected by high-performance liquid chromatography (HPLC), and the cumulative dissolution rate was calculated.

[0039] Experiment 3: Stability and Adhesion Performance of the Ointment This experiment used samples prepared in Examples 1-3 and Comparative Examples 1-4. Stability testing method: Referring to the accelerated testing standards of the 2015 edition of the "Cosmetic Safety Technical Specifications," each sample was sealed and placed in a constant temperature and humidity chamber at 40℃ and 75% relative humidity for 6 months. The properties of the cream were observed periodically, and changes in the adhesion force of the cream were detected using a texture analyzer. Adhesion performance testing method: Thirty healthy volunteers aged 25-45 years were randomly divided into 8 groups. After hair removal and disinfection on the backs of each group, the corresponding sample was heated and softened before being applied. The application time was recorded until the edge of the cream lifted ≥1cm and could not be fixed. Allergic reactions such as redness, swelling, and itching were observed during the application period.

[0040] Table 1. Results of the detection of the kidney-warming and cold-dispelling effects in rats with uterine cold model.

[0041] Table 2 Results of Cumulative Dissolution Rate of Core Active Ingredients over 5 hours

[0042] Table 3 Results of Ointment Stability and Adhesion Performance Tests

[0043] Based on Examples 1-3 and Comparative Example 1, and referring to Tables 1, 2, and 3, it can be seen that when Mantis Egg Case (Sangpiaoxiao) is missing from the raw materials, the kidney-warming and cold-dispelling effects, the dissolution rate of the core effective components, the stability of the ointment, and the application performance all show a significant downward trend. This is because Mantis Egg Case has a synergistic kidney-tonifying and cold-dispelling effect with raw materials such as Phellodendron bark, Eucommia bark, and Cuscuta seed. Its absence not only weakens the overall kidney-warming and uterus-warming effects of the formula, but also reduces the dissolution efficiency of kidney-tonifying effective components such as chlorogenic acid, and adversely affects the adhesion stability of the ointment, resulting in a shorter application time than in Examples 1-3.

[0044] Based on Examples 1-3 and Comparative Example 2, and referring to Tables 1, 2, and 3, it can be seen that replacing fresh clove basil with dried clove basil significantly reduced the cumulative dissolution rate of eugenol in the samples, leading to a weakened warming and dispersing effect on the kidneys, and causing slight adhesion of the paste. This reflects that the volatile active ingredients such as eugenol contained in fresh clove basil are more easily dissolved and exert their warming effect, while the loss of volatile components in dried clove basil during processing and storage not only reduces the dissolution efficiency of the effective ingredients but also affects the forming stability of the paste, highlighting the necessity of fresh clove basil as a raw material.

[0045] Combining Examples 1-3 and Comparative Example 3 with Tables 1, 2, and 3, it can be seen that when paraffin wax was used instead of natural beeswax as the base material, the warming and dispersing effects of the kidneys, the dissolution rate of the core active ingredients, the stability of the ointment, and the application performance of the samples all showed significant deterioration. The average application time was only 2.3 days, three volunteers experienced mild skin redness and swelling, and the ointment severely cracked and hardened after accelerated testing. This is because natural beeswax has excellent transdermal absorption promotion, biocompatibility, and adhesive stability, ensuring the stable dissolution of the active ingredients and their adherence to the skin. Paraffin wax, on the other hand, has poor transdermal absorption, insufficient adhesion, and poor stability, hindering the transdermal absorption of the active ingredients and failing to maintain the long-term stability and good application experience of the ointment. This proves that natural beeswax is a key factor in ensuring product performance when used as the base material.

[0046] Based on Examples 1-3 and Comparative Example 4, and referring to Tables 1, 2, and 3, it can be seen that when the heating and melting temperature in step S3 drops to 55°C, the dissolution rate of the core active ingredients, the warming and dispersing effects on the kidneys, and the application performance of the sample all decrease. This reflects that a heating and melting temperature range of 65-75°C can ensure that natural beeswax and hydrogenated soybean wax are fully melted and uniformly mixed with glycerin to form a uniform and stable plaster matrix. However, the low temperature of 55°C leads to insufficient melting and uneven mixing of the matrix, which in turn affects the dispersion and dissolution of the active ingredients in the matrix, reducing the overall efficacy and application stability of the product. This highlights the important influence of the appropriate melting temperature on the preparation process.

[0047] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A kidney-warming, cold-dispelling, and uterus-warming ointment, characterized in that, The raw materials consist of the following parts by weight: 5-10 parts of Phellodendron bark, 8-12 parts of Mantis egg case, 10-15 parts of Eucommia bark, 4-8 parts of deer antler glue, 3-7 parts of fresh cloves and basil, 8-12 parts of Cuscuta seed, 2-6 parts of human hair charcoal, 12-18 parts of natural beeswax, 6-10 parts of hydrogenated soybean wax, and 2-4 parts of glycerin.

2. A method for preparing a kidney-warming, cold-dispersing, and uterus-warming ointment, characterized in that, The kidney-warming, cold-dispelling, and uterus-warming ointment according to claim 1 comprises the following steps: S1. Classification and processing of Chinese herbal raw materials: Crush and sieve the Chinese herbal raw materials that need to be crushed separately and mix them evenly. Wash the fresh cloves and basil and set them aside. Crush the deer antler glue separately and set it aside. S2. Preparation of Chinese herbal extract: The mixed fine powder of Chinese herbal medicine is extracted by decoction with water. The extracts are combined and concentrated to obtain Chinese herbal extract. Fresh cloves and basil are juiced and then mixed with the extract. S3. Preparation of plaster matrix: Heat and melt natural beeswax and hydrogenated soybean wax, add glycerin and stir evenly to obtain a uniform plaster matrix; S4. Mixing and shaping the paste: Add the Chinese herbal extract to the paste base and stir until well mixed. Then add the dissolved deer antler glue solution and continue stirring until the paste is uniform. S5. Mounting and Cutting: Apply a uniform paste to a pure cotton mounting cloth, and after drying and cooling, cut it into plasters of the preset size.

3. The preparation method of the kidney-warming, cold-dispersing, and uterus-warming ointment according to claim 2, characterized in that, The specific operations of the classification and processing of Chinese herbal raw materials in step S1 include: the Chinese herbal raw materials to be pulverized are Phellodendron bark, mantis egg case, Eucommia bark, Cuscuta seed, and carbonized human hair. They are pulverized separately and passed through a 60-100 mesh sieve, and then mixed evenly to obtain a fine powder of mixed Chinese herbal medicine. The deer antler glue is pulverized separately and passed through an 80-90 mesh sieve.

4. The preparation method of the kidney-warming, cold-dispersing, and uterus-warming ointment according to claim 2, characterized in that, In step S2, the extraction method using water decoction is as follows: Add the mixed Chinese herbal powder to 8-12 times its weight of purified water, decoct at a constant temperature of 60-80℃ for 1-2 hours, filter and collect the filtrate. Add 6-8 times the weight of purified water to the filter residue, boil once more, combine the two filtrates and concentrate to a herbal extract with a relative density of 1.1-1.3; The process of processing fresh clove basil juice and then mixing it with the extract includes the following steps: Crush fresh cloves and basil to extract the juice, filter it, and then mix it evenly with the above-mentioned Chinese herbal extract.

5. The preparation method of the kidney-warming, cold-dispersing, and uterus-warming ointment according to claim 2, characterized in that, Step S2 also includes dissolving the gelatinous raw materials, as follows: Add the pulverized deer antler glue to 5-8 times its weight of purified water, dissolve it in a water bath at 50-60℃, and stir until completely clear before use.

6. The preparation method of the kidney-warming, cold-dispersing, and uterus-warming ointment according to claim 2, characterized in that, In step S3, the temperature during heating and melting is 65-75℃, and the stirring speed is 150-200 r / min; after adding glycerin, continue stirring for 1-2 minutes to obtain a uniform plaster matrix.

7. The preparation method of the kidney-warming, cold-dispersing, and uterus-warming ointment according to claim 2, characterized in that, In step S4, adding the herbal extract to the plaster base and stirring to mix it thoroughly includes the following steps: Add the prepared herbal extract to the plaster matrix, maintain the temperature at 60-70℃, and stir for 2-3 minutes; Add the dissolved deer antler glue solution and continue stirring for 1-2 minutes to obtain a uniform plaster.

8. The preparation method of the kidney-warming, cold-dispersing, and uterus-warming ointment according to claim 2, characterized in that, In step S5, applying the uniform paste onto the pure cotton backing cloth includes the following steps: Lay the pure cotton backing cloth flat, and evenly apply the plaster to the surface of the backing cloth with a coating thickness of 0.6-1.0mm; After coating, place the backing at 35-45℃ to dry for 20-30 minutes, cool to room temperature, and then cut into plasters of the preset size.

9. The preparation method of the kidney-warming, cold-dispersing, and uterus-warming ointment according to claim 8, characterized in that, During the drying process, natural ventilation is used, and the dried paste has no obvious bubbles and a smooth surface.

10. The application of the kidney-warming and cold-dispersing ointment as described in claim 1 in the preparation of medicines for treating kidney yang deficiency, uterine cold and menstrual disorders.

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