Fructose diphosphate processing and impurity removing equipment

Abstract

The invention relates to the technical field of fructose sodium diphosphate processing, in particular to fructose sodium diphosphate processing and impurity removing equipment, a main liquid inlet pipe and a liquid outlet pipe are designed to achieve automatic feeding and taking, after centrifugation is finished, centrifugal pipe fittings are reset under the action of gravity, square connectors can be automatically inserted into square connectors, and the centrifugal pipe fittings are automatically separated from the square connectors. Therefore, the solution backflow connecting assembly for material taking can also be automatically connected after centrifugation is finished, the whole process does not need to be operated by manually opening centrifugal equipment, and the operation is simple and convenient. An innovative square interface connecting mechanism is matched with an electromagnetically-controlled sealing assembly, so that the filtering unit is quickly disassembled and assembled, and the maintenance time is shortened. Due to the design of the detachable crystal precipitation box, the complicated pipeline dismounting process is avoided, the labor intensity of operators is greatly reduced, and the operation process is simplified. The three-stage purification system for centrifugal separation, filtration interception and precipitation collection has a synergistic effect, so that impurity particles with different particle sizes can be effectively removed, and the purification efficiency is improved.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of sodium fructose diphosphate processing, and particularly relates to a sodium fructose diphosphate processing impurity removal device. BACKGROUND

[0002] Sodium fructose diphosphate is an important medical raw material, and its purity requirement is very high. Removing impurities is a key link in the production process, and the impurities of sodium fructose diphosphate are generally removed by first precipitating insoluble substances and then filtering them out, and then adding a specific solvent to make the soluble impurities crystallize, and then filtering them out. In order to accelerate the precipitation of the impurities after crystallization, a centrifugal device is generally used.

[0003] However, when using the traditional centrifugal device, the operations of feeding, taking out and filtering impurities are difficult. In the feeding stage, due to the lack of continuous feeding design, the solution needs to be added every time the machine is stopped, which not only reduces the production efficiency, but also increases the pollution risk due to manual intervention. In the taking-out link, the clarified solution after centrifugation needs to be discharged through complex pipelines, and the residual dead volume leads to the loss of effective components, and the cleaning of the precipitate depends on manual disassembly, which is time-consuming and laborious.

[0004] The most troublesome is to filter impurities and take them out. The existing equipment mostly uses fixed filter screens or filter membranes, and the impurities will continuously accumulate, which needs to be replaced or cleaned frequently. In addition, the repeated disassembly and assembly of the sealing structure easily lead to the wear of the parts, affecting the stability of long-term operation. These operation pain points not only prolong the production cycle, but also restrict the improvement of product purity, and an integrated continuous feeding, dynamic filtering and convenient maintenance optimization scheme is urgently needed. SUMMARY

[0005] Therefore, the present application aims to provide a sodium fructose diphosphate processing impurity removal device to solve the technical problems mentioned in the background.

[0006] In order to achieve the above purpose, the present application provides a sodium fructose diphosphate processing impurity removal device, which comprises a base and a rotating disc connected to the base, and further comprises: A rotating motor is arranged in the base, and the rotating disc is fixedly connected to the output shaft of the rotating motor; A fixed tube is fixedly connected at the center of the rotating disc, a fixed support is fixedly connected to the fixed tube, and a centrifugal pipe is rotatably connected to the outer end of the fixed support, and the centrifugal pipe is filled with sodium fructose diphosphate solution; The total liquid inlet pipe and the total liquid outlet pipe are rotatably connected with the fixed pipe, the middle section of the fixed pipe is provided with a partitioning and sealing part for dividing the fixed pipe into two cavities, the total liquid inlet pipe and the total liquid outlet pipe are respectively communicated with the two cavities in the fixed pipe, the upper cavity of the fixed pipe is communicated with the centrifugal pipe, and the communication position is located at the upper part of the centrifugal pipe, and a solution backflow connecting assembly is arranged between the lower end of the centrifugal pipe and the lower cavity of the fixed pipe for connecting the two.

[0007] Further, the centrifugal pipe is provided with a plurality of groups and is arranged at equal angles on the fixed support.

[0008] Further, the centrifugal pipe comprises a connecting seat, a centrifugal pipe and a centrifugal base, the connecting seat is located at the upper part of the centrifugal pipe and is fixedly connected with the centrifugal pipe, and the centrifugal base is fixedly connected with the lower end of the centrifugal pipe.

[0009] Further, the connecting seat is rotatably connected with the fixed support, a channel for liquid circulation is arranged in the connecting seat, a liquid inlet branch pipe is connected between the connecting seat and the fixed support, the two ends of the liquid inlet branch pipe are respectively communicated with the upper cavity of the fixed pipe and the channel in the connecting seat, the channel in the connecting seat is communicated with the centrifugal pipe, and the liquid inlet branch pipe is a rubber hose with sufficient length.

[0010] Further, a connecting cavity is arranged in the centrifugal base, the connecting cavity is communicated with the centrifugal pipe, a square interface is arranged at the inner end of the centrifugal base, the connecting cavity is communicated with the square interface, and a filter is further arranged between the connecting cavity and the square interface.

[0011] Further, the solution backflow connecting assembly comprises a square pipe and a square joint, the square joint can be connected with the square interface, and the two ends of the square pipe are respectively communicated with the square joint and the lower cavity of the fixed pipe.

[0012] Further, a limiting groove is further fixedly connected with the rotating disc, the centrifugal pipe is slidably connected in the limiting groove, a plurality of balls are further arranged on the side wall of the centrifugal base, the balls are rollingly connected on the inner wall of the limiting groove, and the square joint and the square pipe are respectively fixedly connected on the inner and outer end faces of the rear side plate of the limiting groove.

[0013] Further, a sealing air bag is fixedly installed in the centrifugal base, the sealing air bag is located in the square interface and arranged in a circle, and a sealing piece is further arranged in the centrifugal base.

[0014] Further, the sealing member comprises a sealing groove arranged in the centrifugal base and a sealing sliding plate, the sealing sliding plate is slidingly connected to the inner end of the square connector, the bottom of the sealing sliding plate is fixedly connected with a metal disc, the metal disc is slidingly connected in the sealing groove, the bottom of the sealing groove is provided with an electromagnet, the sealing groove is further provided with a reset spring, the upper and lower ends of the reset spring are connected to the top of the sealing groove and the metal disc respectively, the centrifugal base is further provided with a ventilation flow channel, one end of the ventilation flow channel is communicated with the sealing air bag, and the other end is communicated with the sealing groove.

[0015] Further, the centrifugal base is further provided with a sedimentation tank, the sedimentation tank is arranged below the connecting cavity and is communicated with the connecting cavity, and the sedimentation tank is detachably provided with a crystallization sedimentation box.

[0016] The beneficial effects of the present application are: 1. The designed total liquid inlet pipe and liquid outlet pipe can automatically feed and take materials, and after the centrifugation is completed, the centrifugal pipe is reset under the action of gravity, so that the square connector is automatically inserted into the square connector, and therefore the solution reflux connection assembly for taking materials can also be automatically connected after the centrifugation is completed, and the whole process does not need to manually open the centrifugal equipment for operation, which is simple and convenient.

[0017] 2. The innovative square connector connection mechanism cooperates with the electromagnetically controlled sealing assembly to realize quick disassembly and assembly of the filter unit, so that the maintenance time is shortened. The detachable crystallization sedimentation box design avoids the complex pipe disassembly process, greatly reduces the labor intensity of the operator and simplifies the operation process.

[0018] 3. The three-stage purification system of centrifugal separation, filtration and sedimentation collection cooperates, especially the filter integrated in the centrifugal base and the sedimentation tank combined structure, which can effectively remove impurity particles of different particle sizes, so that the product purity reaches the pharmaceutical grade standard and the purification efficiency is improved.

[0019] 4. The pressure balance design of the sealing air bag and the ventilation flow channel ensures the sealing reliability during long-term operation. The cooperation structure of the ball and the limiting groove reduces the vibration frequency of the equipment during high-speed centrifugation, significantly prolongs the service life of the key components and ensures the production stability. BRIEF DESCRIPTION OF DRAWINGS

[0020] In order to more clearly illustrate the technical solutions in the present application or prior art, the following will briefly introduce the drawings needed to be used in the embodiments or prior art description. Obviously, the drawings in the following description are only a part of the present application, and other drawings can also be obtained by those skilled in the art without creative labor.

[0021] Figure 1 It is the overall structure principle schematic diagram of the device of the present application.

[0022] Figure 2 Structure diagram of the bottom perspective view of the device of the present application.

[0023] Figure 3 Structure diagram of the principle of the structure above the rotating disc in the device of the present application.

[0024] Figure 4 Structure diagram of the fixed tube and fixed support part in the device of the present application.

[0025] Figure 5 Structure diagram of the internal structure of the centrifugal tube in the device of the present application.

[0026] Figure 6 Figure 5 Enlarged view of part A.

[0027] Marked as: 101, base, 102, rotating disc, 103, fixed tube, 104, total liquid inlet pipe, 105, liquid outlet pipe, 106, rotating motor, 107, fixed support, 108, connecting seat, 109, centrifugal tube, 110, centrifugal base, 111, limiting groove, 112, ball, 113, crystallization precipitation box, 114, sealing plug, 115, liquid inlet branch pipe, 116, square tube, 117, square joint, 118, connecting cavity, 119, precipitation groove, 120, sealing air bag, 121, sealing groove, 122, electromagnet, 123, sealing sliding plate, 124, return spring, 125, air passage, 126, filter, 127, square interface. DETAILED DESCRIPTION

[0028] In order to make the purpose, technical scheme and advantages of the present application more clear and obvious, the present application is further described in detail below in combination with specific embodiments.

[0029] It should be noted that, unless otherwise defined, the technical terms or scientific terms used in the present application should be understood as the common meanings understood by those skilled in the art to which the present application belongs. The terms "first", "second" and similar words used in the present application do not represent any order, number or importance, but are only used to distinguish different components. The terms "include" or "contain" and similar words mean that the elements or objects before the words cover the elements or objects listed after the words and their equivalents, and do not exclude other elements or objects. The terms "connect" or "connected" and similar words are not limited to physical or mechanical connections, but can include electrical connections, whether direct or indirect. The terms "up", "down", "left", "right" and the like are only used to represent relative positional relationships, and when the absolute positions of the described objects change, the relative positional relationships may also change accordingly.

[0030] In a first aspect, the present application provides a device for separating and collecting a target substance from a liquid sample, comprising:​Figure 1 、 Figure 2 and Figure 3 As shown in the drawings, in order to accelerate the precipitation of impurities after crystallization, the impurity removal process of sodium fructose diphosphate generally needs to use a centrifugal device. However, when using a traditional centrifugal device, the operations of feeding, taking out and filtering impurities are difficult. Therefore, the base 101 and the rotating disc 102 rotatingly connected to the base 101 are designed, and a rotating motor 106 is arranged in the base 101, and the rotating disc 102 is fixedly connected to the output shaft of the rotating motor 106.

[0031] The key point is that the fixed pipe 103 is fixedly connected at the center of the rotating disc 102, and the fixed support 107 is fixedly connected to the fixed pipe 103, and the centrifugal pipe element is rotatingly connected to the outer end of the fixed support 107, and the centrifugal pipe element is filled with sodium fructose diphosphate solution. The inner middle section of the fixed pipe 103 is provided with a partitioning and sealing portion for dividing the fixed pipe 103 into two cavities. The upper cavity of the fixed pipe 103 is in communication with the centrifugal pipe element, and the communication position is located at the upper part of the centrifugal pipe element. The lower end of the centrifugal pipe element is connected to the lower cavity of the fixed pipe 103 through a solution backflow connecting assembly.

[0032] The total liquid inlet pipe 104 for feeding and the liquid outlet pipe 105 for discharging are respectively in communication with the upper and lower cavities of the fixed pipe 103, and the total liquid inlet pipe 104 and the liquid outlet pipe 105 are rotatingly connected to the fixed pipe 103.

[0033] The centrifugal pipe element includes the connecting seat 108, the centrifugal pipe 109 and the centrifugal base 110. The connecting seat 108 is located at the upper part of the centrifugal pipe 109 and is fixedly connected thereto. The centrifugal base 110 is fixedly connected to the lower end of the centrifugal pipe 109, and the connecting seat 108 is rotatingly connected to the fixed support 107. The total liquid inlet pipe 104 and the liquid outlet pipe 105 can automatically feed and take out materials. After the centrifugation is completed, the centrifugal pipe element is reset under the action of gravity, so that the square joint 117 is automatically inserted into the square interface 127. Therefore, the solution backflow connecting assembly for taking out materials can also be automatically connected after the centrifugation is completed. The whole process does not need to manually open the centrifugal device for operation, which is simple and convenient.

[0034] Preferably, the centrifugal pipe element is provided with a plurality of groups and is arranged at equal angles on the fixed support 107.

[0035] The second aspect of the present application is as follows: Figure 4 、 Figure 5 and Figure 6As shown, the traditional centrifugal equipment loading, taking material generally need to close the device and open the operation, and generally do not have filtering function, so the most troublesome is the filter impurities and take out. The connecting seat 108 is provided with a channel for liquid circulation, the connecting seat 108 and the fixed support 107 are connected with the liquid inlet branch pipe 115, the two ends of the liquid inlet branch pipe 115 are respectively communicated with the cavity of the fixed pipe 103 and the channel in the connecting seat 108, the channel in the connecting seat 108 is communicated with the centrifugal tube 109, and the liquid inlet branch pipe 115 is a rubber hose with sufficient length.

[0036] The centrifugal base 110 is provided with a connecting cavity 118, the connecting cavity 118 is communicated with the centrifugal tube 109, and the inner end of the centrifugal base 110 is provided with a square interface 127, the connecting cavity 118 is communicated with the square interface 127, and the connecting cavity 118 and the square interface 127 are further provided with a filter 126. The innovative square interface 127 connection mechanism cooperates with the electromagnetic control sealing assembly, realizes the quick disassembly of the filter unit, and shortens the maintenance time by more than 80%. The detachable crystallization precipitation box 113 design avoids the complex pipeline disassembly process, greatly reduces the labor intensity of the operator and simplifies the operation process.

[0037] The centrifugal base 110 is provided with a connecting cavity 118, the connecting cavity 118 is communicated with the centrifugal tube 109, and the inner end of the centrifugal base 110 is provided with a square interface 127, the connecting cavity 118 is communicated with the square interface 127, and the connecting cavity 118 and the square interface 127 are further provided with a filter 126. The innovative square interface 127 connection mechanism cooperates with the electromagnetic control sealing assembly, realizes the quick disassembly of the filter unit, and shortens the maintenance time by more than 80%. The detachable crystallization precipitation box 113 design avoids the complex pipeline disassembly process, greatly reduces the labor intensity of the operator and simplifies the operation process.

[0038] In addition, the centrifugal base 110 is fixedly provided with a sealed air bag 120, the sealed air bag 120 is located in the square interface 127 and is provided with a ring, and the centrifugal base 110 is further provided with a sealing member. The sealing member comprises a sealing groove 121 and a sealing sliding plate 123 provided in the centrifugal base 110, the sealing sliding plate 123 is slidably connected to the inner end of the square interface 127, and the bottom of the sealing sliding plate 123 is fixedly connected with a metal disc, the metal disc is slidably connected in the sealing groove 121, and the bottom of the sealing groove 121 is provided with an electromagnet 122, and the sealing groove 121 is further provided with a reset spring 124, and the upper and lower ends of the reset spring 124 are connected to the top of the sealing groove 121 and the metal disc respectively, and the centrifugal base 110 is further provided with a ventilation flow channel 125, one end of the ventilation flow channel 125 is communicated with the sealed air bag 120, and the other end is communicated with the sealing groove 121, and the communication is located at the bottom of the sealing groove 121.

[0039] The centrifugal base 110 is further provided with a sedimentation tank 119, the sedimentation tank 119 is located below the connecting cavity 118 and is communicated with the connecting cavity 118, and the sedimentation tank 119 is detachably provided with a crystallization sedimentation box 113. The three-stage purification system of centrifugal separation, filtration retention and sedimentation collection cooperates, especially the combined structure of the filter 126 integrated in the centrifugal base 110 and the sedimentation tank 119, which can effectively remove impurity particles of different particle sizes, and the product purity reaches the pharmaceutical grade standard and improves the purification efficiency.

[0040] In summary, the total liquid inlet pipe 104 and the liquid outlet pipe 105 can automatically feed and take materials, and after the centrifugation is completed, the centrifugal pipe is reset under the action of gravity, so that the square joint 117 is automatically inserted into the square interface 127, and therefore the solution reflux connection assembly for taking materials can also be automatically connected after the centrifugation is completed, and the whole process does not need to manually open the centrifugal equipment for operation, which is simple and convenient.

[0041] The innovative square interface 127 connection mechanism cooperates with the electromagnetically controlled sealing assembly to realize rapid disassembly and assembly of the filter unit, so that the maintenance time is shortened by more than 80%. The detachable crystallization sedimentation box 113 design avoids the complex pipe disassembly process, greatly reduces the labor intensity of the operator and simplifies the operation process. The three-stage purification system of centrifugal separation, filtration retention and sedimentation collection cooperates, especially the combined structure of the filter 126 integrated in the centrifugal base 110 and the sedimentation tank 119, which can effectively remove impurity particles of different particle sizes, and the product purity reaches the pharmaceutical grade standard and improves the purification efficiency. The pressure balance design of the sealed air bag 120 and the ventilation flow channel 125 ensures the sealing reliability during long-term operation. The cooperation structure of the ball 112 and the limiting groove 111 reduces the vibration frequency of the equipment during high-speed centrifugation, significantly prolongs the service life of the key components and ensures the production stability.

[0042] Those skilled in the art should understand that the above discussion of any embodiment is only intended to be exemplary in nature and is not intended to suggest any limitation on the scope of the present application as defined by the claims; the above examples or technical features in the different embodiments can be combined with each other, the steps can be implemented in any order, and there are many other variations of the different aspects of the present application as described above, which are not provided in detail in order to be brief.

[0043] The present application is intended to cover all such alternatives, modifications, and variations as come within the scope of the broadest possible interpretation of the appended claims. Accordingly, any and all such alternations, modifications, equivalents, improvements and the like are intended to be encompassed by the present application.

Claims

1. A processing and impurity removal device for sodium fructose diphosphate, comprising a base (101) and a turntable (102) rotatably connected to the base (101), characterized in that, The impurity removal device also includes: A rotating motor (106) is installed inside the base (101), and the turntable (102) is fixedly connected to the output shaft of the rotating motor (106); A fixed tube (103) is fixedly connected to the center of the turntable (102). A fixed bracket (107) is fixedly connected to the fixed tube (103). A centrifuge tube is rotatably connected to the outer end of the fixed bracket (107). The centrifuge tube is filled with fructose diphosphate sodium solution. The main inlet pipe (104) and the outlet pipe (105) are rotatably connected to the fixed pipe (103). The middle section of the fixed pipe (103) is provided with a partition sealing part to divide the fixed pipe (103) into upper and lower cavities. The main inlet pipe (104) and the outlet pipe (105) are respectively connected to the upper and lower cavities in the fixed pipe (103). The upper cavity of the fixed pipe (103) is connected to the centrifuge tube, and the connection point is located in the upper part of the centrifuge tube. The lower end of the centrifuge tube and the lower cavity of the fixed pipe (103) are provided with a solution reflux connection assembly to connect the two.

2. The fructose diphosphate sodium processing and impurity removal equipment according to claim 1, characterized in that, The centrifugal tubes are provided in several groups and are arranged at equal angles on the fixed support (107).

3. The fructose diphosphate sodium processing and impurity removal equipment according to claim 1 or 2, characterized in that, The centrifuge fitting includes a connecting seat (108), a centrifuge tube (109), and a centrifuge base (110). The connecting seat (108) is located on the upper part of the centrifuge tube (109) and is fixedly connected thereto. The centrifuge base (110) is fixedly connected to the lower end of the centrifuge tube (109).

4. The fructose diphosphate sodium processing and impurity removal equipment according to claim 3, characterized in that, The connecting seat (108) is rotatably connected to the fixed bracket (107), and the connecting seat (108) is provided with a channel for liquid flow. A liquid inlet branch pipe (115) is connected between the connecting seat (108) and the fixed bracket (107). The two ends of the liquid inlet branch pipe (115) are respectively connected to the cavity on the fixed tube (103) and the channel in the connecting seat (108). The channel in the connecting seat (108) is connected to the centrifuge tube (109). The liquid inlet branch pipe (115) is a rubber hose with sufficient length reserved.

5. The fructose diphosphate sodium processing and impurity removal equipment according to claim 3, characterized in that, The centrifuge base (110) is provided with a connecting cavity (118), which is connected to the centrifuge tube (109). The centrifuge base (110) is provided with a square interface (127) at its inner end. The connecting cavity (118) is connected to the square interface (127), and a filter (126) is provided between the connecting cavity (118) and the square interface (127).

6. The fructose diphosphate sodium processing and impurity removal equipment according to claim 5, characterized in that, The solution reflux connection assembly includes a square tube (116) and a square connector (117). The square connector (117) can be connected to the square interface (127). The two ends of the square tube (116) are respectively connected to the square connector (117) and the lower cavity of the fixed tube (103).

7. The fructose diphosphate sodium processing and impurity removal equipment according to claim 6, characterized in that, The turntable (102) is also fixedly connected to a limiting groove (111), the centrifugal tube is slidably connected in the limiting groove (111), and the side wall of the centrifugal base (110) is also provided with a number of balls (112), the balls (112) are slidably connected in the inner wall of the limiting groove (111), and the square joint (117) and the square tube (116) are respectively fixedly connected to the inner and outer end faces of the rear side plate of the limiting groove (111).

8. A fructose diphosphate sodium processing and impurity removal device according to claim 5 or 6, characterized in that, A sealing airbag (120) is fixedly installed inside the centrifuge base (110). The sealing airbag (120) is located inside the square interface (127) and is arranged in a ring. A sealing component is also provided inside the centrifuge base (110).

9. The fructose diphosphate sodium processing and impurity removal equipment according to claim 8, characterized in that, The sealing component includes a sealing groove (121) and a sealing slide plate (123) disposed in the centrifugal base (110). The sealing slide plate (123) is slidably connected to the inner end of the square interface (127), and a metal disk is fixedly connected to the bottom of the sealing slide plate (123). The metal disk is slidably connected in the sealing groove (121), and an electromagnet (122) is provided at the bottom of the sealing groove (121). A return spring (124) is also provided in the sealing groove (121). The upper and lower ends of the return spring (124) are respectively connected to the top of the sealing groove (121) and the metal disk. An air passage (125) is also provided in the centrifugal base (110). One end of the air passage (125) is connected to the sealing airbag (120), and the other end is connected to the sealing groove (121), and the connection is located at the bottom of the sealing groove (121).

10. The fructose diphosphate sodium processing and impurity removal equipment according to claim 5, characterized in that, The centrifuge base (110) is also provided with a sedimentation tank (119), which is located below and communicates with the connecting cavity (118), and a crystallization sedimentation box (113) is detachably provided in the sedimentation tank (119).

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