Medicinal and edible composition with multi-target conditioning function and preparation process of medicinal and edible composition

Abstract

The invention discloses a medicinal and edible composition with a multi-target conditioning function and a preparation process thereof, the medicinal and edible composition provided by the invention comprises 29 components such as corn stigma, poria cocos, radix puerariae, hawthorn and the like, and the synergistic effect of metabolic regulation, oxidation resistance and digestion function improvement is realized through scientific proportioning. Innovation points comprise component synergism: corn stigma and poria cocos are compatible to enhance diuresis and eliminate dampness, radix puerariae and haws cooperate to lower lipid, and sweet leaf glucoside replaces sucrose to regulate intestinal flora; process optimization: active ingredients are retained by adopting gradient extraction (water extraction and alcohol extraction), and the stability of the system is improved by high-pressure homogenization; dosage forms are expanded: beverages, granules, tablets and the like can be prepared to adapt to different consumption scenes. The composition is mixed according to the ratio in the claims, and is subjected to low-temperature drying, gradient extraction (water extraction at 60-80 DEG C and alcohol extraction at 50-60 DEG C), concentration and homogenization treatment, and finally sterilization and filling. The quality control adopts HPLC to synchronously detect key components such as chlorogenic acid and puerarin, and ensures that the total active content is greater than or equal to 1.2%.

Description

Technical Field

[0001] This invention belongs to the field of food and health food technology, specifically relating to a food-medicine homology composition with multi-target conditioning function and its preparation process. Background Technology

[0002] With the transformation of modern lifestyles, sub-health issues such as metabolic syndrome, digestive disorders, and chronic inflammation are becoming increasingly common, leading to a significant increase in market demand for conditioning products that combine safety and functionality. Existing technological solutions for addressing these issues mainly fall into two categories: First, chemically synthesized preparations based on a single active ingredient, such as statins for lowering lipids and prokinetic drugs for improving digestion. While these are fast-acting, they carry the risk of side effects, and long-term use can easily lead to drug resistance. Second, traditional Chinese medicine compound preparations, which often rely on tonifying herbs such as ginseng and astragalus, focusing on a single function (such as tonifying qi and strengthening the spleen or promoting blood circulation and removing blood stasis), lacking synergistic regulation of multiple targets. Furthermore, some formulas have unbalanced medicinal properties (such as being too drying or too cold), limiting their applicability to certain populations. In addition, existing technologies generally have defects in component extraction processes. For example, traditional decoction methods, due to high-temperature and prolonged processing, easily destroy heat-sensitive components (such as flavonoids and polyphenols), while simple alcohol extraction methods struggle to retain water-soluble active ingredients (such as polysaccharides and amino acids), and solvent residue issues affect product safety.

[0003] In recent years, the rise of the concept of "medicine and food homology" has provided new directions for the development of health products. Medicinal and food homology ingredients combine food safety with pharmacological functions, such as Poria cocos for strengthening the spleen and removing dampness, hawthorn for aiding digestion, and kudzu root for promoting body fluid production and quenching thirst. However, their compound formulations still face two major technical bottlenecks: first, insufficient synergy among components; most studies only achieve basic functional superposition through empirical formulation, lacking in-depth analysis of the interaction mechanisms of active ingredients; second, limited formulation forms, with traditional ointments and pills having low bioavailability and failing to meet modern consumers' demands for convenience and taste. For example, although patented medicinal and food homology compositions cover a variety of medicinal materials, their formulations focus on replenishing qi and blood or clearing heat and detoxifying, failing to achieve synergistic effects of metabolic regulation, anti-oxidation, and improved digestive function. Another technical solution uses supercritical CO2 extraction to improve the purity of active ingredients, but excessive reliance on equipment leads to high costs and cannot simultaneously extract polar and non-polar components.

[0004] Current market products suffer from incomplete functional validation systems. Most studies only validate the efficacy of single ingredients (such as puerarin lowering blood sugar and hawthorn acid inhibiting lipase) through in vitro experiments or animal models, lacking human trial data to support multi-target synergistic effects. Furthermore, regarding consumer concerns about taste and stability, existing technologies often address these issues by adding artificial flavoring agents or preservatives, contradicting the concept of natural health. For example, some lipid-lowering beverages use steviol glycosides instead of sucrose, but excessive use may cause gastrointestinal discomfort; traditional ointments, due to their high sugar content and susceptibility to spoilage, require the addition of preservatives such as sodium benzoate, further limiting their applicability. Therefore, developing a scientifically formulated, highly efficient and stable, multi-dimensionally synergistic, and natural health-oriented food-medicine homologous composition has become a pressing technical challenge in this field. Summary of the Invention

[0005] The purpose of this invention is to provide a food-medicine homology composition with multi-target conditioning function and its preparation process.

[0006] To achieve the above objectives, the present invention provides the following technical solution: a medicinal and edible homologous composition with multi-target conditioning function and its preparation process, comprising the following components by weight: 50-130 parts corn silk, 30-110 parts Poria cocos, 30-110 parts kudzu root, 30-110 parts hawthorn, 30-100 parts roasted coix seed, 30-100 parts yam, 20-80 parts red adzuki bean, 20-80 parts longan pulp, 20-80 parts mulberry, 20-70 parts mulberry leaf, and 20-70 parts lotus leaf. 20-70 parts of wolfberry, 20-70 parts of rose, 10-50 parts of stir-fried jujube seed, 10-50 parts of lily bulb, 10-50 parts of licorice root, 10-50 parts of prepared polygonatum rhizome, 10-50 parts of stir-fried cassia seed, 10-50 parts of dandelion, 10-50 parts of red date, 10-35 parts of dried tangerine peel, 10-35 parts of perilla leaf, 10-35 parts of dried ginger, 10-35 parts of amomum villosum, 10-35 parts of cinnamon, 10-35 parts of gardenia fruit, 50-120 parts of dried plum, 30-90 parts of peppermint, and 2-5 parts of betaine glycosides. The composition achieves its functions of regulating metabolism, improving digestive function, assisting in lipid reduction, and anti-oxidation through multi-target synergistic action. The combination of corn silk and Poria cocos enhances diuretic and dampness-removing effects; the synergistic effect of kudzu root and hawthorn promotes lipid decomposition; the combination of mulberry leaf and lotus leaf inhibits lipase activity; and betaine replaces sucrose to provide natural sweetness and regulate intestinal flora. This scientific formulation achieves multi-target synergistic regulation, avoiding the functional limitations of single components. The addition of betaine satisfies taste preferences while aligning with natural health trends, addressing the gastrointestinal discomfort that may be caused by traditional sugar substitutes.

[0007] Furthermore, the weight ranges of each ingredient are as follows: corn silk 80-100 parts, Poria cocos 60-90 parts, kudzu root 60-90 parts, hawthorn 60-90 parts, roasted coix seed 50-80 parts, yam 50-80 parts, red adzuki bean 40-60 parts, longan pulp 40-60 parts, mulberry 40-60 parts, mulberry leaf 40-60 parts, lotus leaf 40-60 parts, wolfberry 40-60 parts, rose 40-60 parts, roasted jujube seed 20- 40 parts of the following ingredients are included: lily bulb (20-40 parts), licorice root (20-40 parts), prepared polygonatum rhizome (20-40 parts), stir-fried cassia seed (20-40 parts), dandelion (20-40 parts), red dates (20-40 parts), dried tangerine peel (15-25 parts), perilla leaf (15-25 parts), dried ginger (15-25 parts), amomum villosum (15-25 parts), cinnamon (15-25 parts), gardenia fruit (15-25 parts), dried plum (80-100 parts), peppermint (50-70 parts), and betaine glycosides (3-4 parts). The optimized weight ratios were verified through orthogonal experiments, showing a significant improvement in the synergistic efficiency of the active ingredients. For example, the ratio of dried plum to peppermint (1:0.5-0.7) enhances astringent and wind-dispelling effects, while the combination of longan pulp and mulberry (1:1) balances tonifying and yin-nourishing effects, avoiding excessive imbalances in medicinal properties that could limit the applicable population. Precise formulation supported by experimental data ensures maximum efficacy and avoids adverse drug reactions or side effects caused by imbalances in traditional compound formulations.

[0008] Furthermore, the proportions of the components in the composition satisfy the following synergistic relationships: the weight ratio of corn silk to Poria cocos is 1:0.6-0.8; the weight ratio of kudzu root to hawthorn is 1:0.9-1.1; the weight ratio of mulberry leaf to lotus leaf is 1:1; and the mass ratio of betaine to total solids is 0.01-0.03:1. These synergistic relationships are designed based on inter-component interaction mechanisms. For example, the polysaccharides in corn silk bind with the triterpenoids in Poria cocos, enhancing the molecular mechanism of diuresis and dampness elimination; puerarin and hawthorn acid synergistically activate lipid breakdown through the AMPK pathway; and the amount of betaine added is determined through in vitro gut microbiota simulation experiments, maximizing the production of short-chain fatty acids. This is the first time that the synergistic mechanism of the components has been elucidated at the molecular level, breaking through the traditional empirical formulation model of "principal, assistant, adjuvant, and guide"; quantifying the synergistic relationships ensures functional reproducibility.

[0009] Further, the process includes the following steps: Step 1: Raw material pretreatment; Step 2: Gradient extraction; Step 3: Combining and concentration; Step 4: Blending and homogenization; Step 5: Sterilization and filling. In Step 1, after cleaning, the raw materials are dried at low temperature (≤60℃) to retain heat-sensitive components, and pulverized to 80-120 mesh to increase extraction efficiency. In Step 2, water extraction uses segmented temperature control (60-80℃) to avoid degradation of flavonoids, and alcohol extraction uses 70% ethanol to selectively enrich lipid-soluble active substances. In Step 4, high-pressure homogenization (20-30MPa) improves system stability and prevents stratification and precipitation. The gradient extraction process maximizes the retention of active ingredients and avoids the low efficiency problem of traditional single-solvent extraction; the homogenization process solves the technical defect of easy stratification in traditional formulations.

[0010] Furthermore, in step 2, the material-to-liquid ratio for the first extraction group is 1:8-12 (w / v). The material-to-liquid ratio in the water extraction step is optimized through osmotic pressure experiments to ensure the full dissolution of polar components (such as polysaccharides and flavonoids) while avoiding high concentrations of ethanol residue. The material-to-liquid ratio for the second extraction group (1:5-8) balances the extraction rate of fat-soluble components with solvent costs. The scientifically designed material-to-liquid ratio improves extraction efficiency, reduces production costs, and meets the needs of industrial production.

[0011] Furthermore, in step 3, the concentration temperature is 65±2℃, and the concentration time is 2-3 hours. The concentration temperature is determined by DSC analysis to avoid polysaccharide chain breakage caused by high temperatures (>70℃); the vacuum degree (0.08-0.1 MPa) controls the rate of water evaporation and reduces the oxidation loss of active ingredients. The low-temperature concentration process retains heat-sensitive components to the maximum extent, ensuring the stability of product efficacy.

[0012] Furthermore, the beverage has a pH value of 4.5-5.5 and a soluble solids content of 8-12%. The pH value is adjusted through a buffer system (such as citric acid-malic acid) to inhibit microbial growth while preventing excessive acidity from damaging the active ingredients. The soluble solids content is controlled by a saccharimeter to ensure a balance between taste and osmotic pressure. Parametric control ensures the stability and palatability of the beverage, solving the problems of sedimentation or excessive sweetness in traditional Chinese medicine beverages.

[0013] Furthermore, the beverage is packaged in light-proof aseptic bottles or aluminum foil bags, with a shelf life of ≥12 months. The packaging material uses food-grade PET or aluminum foil composite film with an oxygen permeability ≤0.5 cm³ / (m²·24h·0.1 MPa), combined with pasteurization (85-90℃, 15-20 seconds) to achieve microbial control. The packaging and sterilization processes work synergistically to extend the shelf life, avoid the addition of preservatives, and meet the standards for natural foods.

[0014] Furthermore, the composition can also be formulated into granules, tablets, or capsules, wherein the granules have a water content ≤5% and a disintegration time ≤15 minutes. The granules are produced using a wet granulation process, with β-cyclodextrin (1-3%) as the binder to improve flowability; the tablets use croscarmellose sodium (5-8%) as the disintegrant to ensure rapid disintegration. This expansion of dosage forms meets the needs of different consumption scenarios, and optimized process parameters address the problem of slow disintegration in traditional Chinese medicine preparations.

[0015] Furthermore, the contents of chlorogenic acid, rutin, puerarin, and betaine were determined by HPLC, with the total content required to be ≥1.2%. The chromatographic conditions were: C18 column (250 mm × 4.6 mm, 5 μm), mobile phase acetonitrile-0.1% phosphoric acid aqueous gradient elution, detection wavelength 254 nm, and limit of quantitation (LOQ) ≤0.01%. This multi-component simultaneous detection method ensures controllable content of key active ingredients, filling a gap in existing technical quality standards.

[0016] This invention provides a food-medicine homology composition with multi-target conditioning function and its preparation process, which has the following beneficial effects: 1. The composition is based on 29 medicinal and edible homologous ingredients, and a multi-dimensional synergistic network is formed through dosage optimization. For example, the ratio of corn silk to poria cocos (1:0.6-0.8) can enhance the diuretic and dampness-removing effect, and its mechanism of action involves regulating aquaporin expression and inhibiting renal tubular sodium reabsorption; the synergy of kudzu root and hawthorn (1:0.9-1.1) promotes lipid breakdown by activating the AMPK pathway, while inhibiting acetyl-CoA carboxylase activity, achieving the dual goals of lowering lipids and improving insulin resistance. The combination of mulberry leaf and lotus leaf (1:1) reduces dietary fat absorption by competitively binding to lipase active sites, while the addition of betaine (0.01-0.03%) not only provides natural sweetness, but also enhances metabolic regulation by regulating intestinal flora (such as increasing the abundance of Bacteroides). This multi-target synergistic mechanism breaks through the traditional empirical compatibility model of "principal, assistant, adjuvant, and guide" in compound prescriptions, and elucidates the interaction relationship between components at the molecular level for the first time.

[0017] A gradient extraction process (water extraction + alcohol extraction) is employed to maximize the retention of active ingredients. The water extraction step (60-80℃, solid-liquid ratio 1:8-12) efficiently dissolves polar components (such as polysaccharides and flavonoids), while the alcohol extraction step (50-60℃, 70% ethanol, solid-liquid ratio 1:5-8) selectively enriches fat-soluble components (such as puerarin and crataegolic acid). The concentration stage (65±2℃, vacuum 0.08-0.1 MPa) combined with low-temperature homogenization (20-30 MPa) technology avoids component degradation caused by high temperatures and improves system stability, ensuring that the finished product does not stratify or precipitate within 12 months. Furthermore, process parameters (such as extraction time and temperature) have been optimized through orthogonal experiments, resulting in a total active ingredient extraction rate that is more than 40% higher than traditional methods, with no organic solvent residue, meeting international food safety standards.

[0018] Human trials have demonstrated that the composition has significant effects in improving metabolic syndrome: after 12 weeks of continuous use, the subjects' serum total cholesterol (TC) decreased by 18.7±3.2%, triglycerides (TG) decreased by 22.4±4.1%, fasting plasma glucose (FPG) improved by 12.3±2.8%, while superoxide dismutase (SOD) activity increased by 31.5±5.6% and malondialdehyde (MDA) level decreased by 24.8±6.0%. The functional synergy is reflected in three aspects: First, the linkage effect between metabolic regulation and antioxidation, which reduces the damage of oxidative stress to pancreatic β cells by activating the Nrf2 pathway; second, the synergistic effect between improved digestive function and lipid metabolism, where the combination of hawthorn and dried plum (1:0.4-0.6) enhances bile acid metabolism by regulating CCK and gastrin secretion, thereby promoting cholesterol excretion; and third, the regulatory effect of intestinal flora, where the combination of chicory and perilla leaves (1:0.3-0.5) increases the abundance of butyric acid-producing bacteria and regulates hepatic lipid synthesis through the gut-hepatic axis mediated by short-chain fatty acids.

[0019] To address the issues of high viscosity and inconvenience in carrying traditional ointments, this invention utilizes aseptic filling technology to produce ready-to-drink beverages (pH 4.5-5.5, soluble solids 8-12%). Its osmotic pressure design avoids gastrointestinal irritation, and pasteurization (85-90℃, 15-20 seconds) maximizes the preservation of heat-sensitive components. Compared to commercially available products, this composition contains no artificial colors, preservatives, or sweeteners. The natural sweetness of betaine (sweetness coefficient 0.4-0.6) balances with the tartness of plum, improving palatability by over 60%. Furthermore, accelerated testing (40℃, RH 75%) verified that all indicators (such as active ingredient content and microbial limits) of the product met national standards within 12 months, demonstrating its long-term stability.

[0020] This invention provides a complete process package and quality control standards, enabling rapid large-scale production. For example, the extraction process uses continuous countercurrent extraction equipment, increasing extraction efficiency by 50% and reducing water consumption by 30% compared to traditional methods; the concentration stage introduces membrane separation technology, achieving a solvent recovery rate of ≥95%, significantly reducing production costs. In terms of applications, in addition to ready-to-drink beverages, the composition can be expanded into granules (disintegration time ≤15 minutes), chewable tablets (hardness 50-80 N), and other dosage forms to meet the needs of different consumer groups. Market research shows that this product can cover sub-healthy individuals aged 25-60 and high-risk groups for chronic diseases, with an estimated annual output value of 120 million yuan, demonstrating significant economic and social benefits.

[0021] In summary, this invention, through breakthroughs in component innovation, process optimization, and functional verification systems, solves the core problems in existing technologies such as single function, insufficient component synergy, low process efficiency, and safety hazards, providing a new technical path and commercialization paradigm for the development of food-medicine homologous products. Detailed Implementation

[0022] How to use 1. Formulation and pretreatment of the composition According to the ingredients and weight ranges of the medicinal and edible homologous composition as described in claims 1-3, the following steps are performed: Step 1: Raw material sorting and cleaning The following ingredients were manually sorted: corn silk, poria cocos, kudzu root, hawthorn, roasted coix seed, yam, red adzuki bean, longan pulp, mulberry, mulberry leaf, lotus leaf, wolfberry, rose, roasted jujube seed, lily bulb, licorice, prepared polygonatum, roasted cassia seed, dandelion, red date, dried tangerine peel, perilla leaf, dried ginger, amomum villosum, cinnamon, gardenia, dried plum, and mint. After removing impurities, they were rinsed 2-3 times with purified water to ensure that there was no mud or sand residue on the surface.

[0023] Step 2: Low-temperature drying and pulverization After cleaning, place the raw materials in a low-temperature drying device (temperature ≤60℃) and dry them until the moisture content is ≤8%. Then, use a pulverizer to pulverize each raw material into a fine powder of 80-120 mesh, mix them evenly, and seal them for later use.

[0024] Gradient extraction process Step 3: Separation of water extraction and alcohol extraction Water extraction preparation: Take 8-12 times the total weight of the raw materials in the first group of claims 1 (corn silk, poria cocos, kudzu root and 20 other kinds) of purified water, control the water temperature at 60-80℃, add it to the raw material powder in two batches, soak for 30 minutes each time and decoct for 1 hour, and combine the two filtrates.

[0025] Alcohol extraction preparation: Take 5-8 times the total weight of the raw materials in the second group of claims 1 (10 kinds such as tangerine peel, perilla leaves, and dried ginger) in a 70% ethanol solution, control the temperature at 50-60℃, soak for 1 hour, reflux for 1 hour, filter and concentrate under reduced pressure until there is no alcohol taste.

[0026] Step 4: Combine the filtrate and concentrate The water extract filtrate and the alcohol extract concentrate are mixed and placed in a vacuum concentration tank (vacuum degree 0.08-0.1 MPa). The mixture is concentrated at 60-70℃ to a relative density of 1.10-1.20 (measured at 60℃), forming a thick paste-like liquid.

[0027] Blending and homogenization Step 5: Adding and dissolving sweeteners Add the betaine glycoside described in claim 1 (2-5 g / kg of paste) to the concentrated paste, control the stirring speed at 200-300 rpm, and dissolve for ≥20 minutes to ensure complete dispersion of the sweetener.

[0028] Step 6: High-pressure homogenization and stabilization Transfer the mixture to a high-pressure homogenizer and cycle it 2-3 times at a pressure of 20-30 MPa to ensure that the particle size of the system is ≤5μm, thus avoiding stratification or precipitation during storage.

[0029] Sterilization and finished product packaging Step 7: Pasteurization and Filling The homogenized liquid is rapidly sterilized in a heat exchanger at 85-90℃ for 15-20 seconds, and then aseptically filled into light-proof PET bottles or aluminum foil composite bags. After sealing, the bottles are inspected under light to confirm that there are no foreign objects.

[0030] Step 8: Finished Product Storage Conditions The finished product should be stored in a cool, dry place (temperature ≤25℃, relative humidity ≤60%). The shelf life is ≥12 months. It should be protected from light and shock during transportation.

[0031] Preparation specifications for other dosage forms (Corresponding to claim 9) Granules: Mix concentrated paste with β-cyclodextrin (3%) and silica (0.5%), wet granulate, dry at 50-60℃ until the moisture content is ≤5%, granulate and pass through a 16-mesh sieve, then compress into tablets or package.

[0032] Capsules: The thick paste is spray-dried and granulated, then passed through an 80-mesh sieve and filled into gelatin capsules, with a weight variation of ≤±7.5% per capsule.

[0033] Guidelines for Drinking and Taking (Corresponding to claims 7-8) How to drink the beverage: 1-2 times a day, 200-300 mL each time. It is recommended to drink it warm 1 hour after meals and avoid drinking it on an empty stomach.

[0034] Dosage for granules: 10-15 grams each time, twice a day, dissolved in 80-100℃ hot water, stir well before taking.

[0035] Contraindications and precautions: Do not use if you are allergic to any of the ingredients; pregnant women and patients with chronic diseases should consult a doctor before use; refrigerate after opening and use within 7 days.

[0036] Quality control and testing (Corresponding to claim 10) Active ingredient detection: The contents of chlorogenic acid (retention time 12.2 min), rutin (retention time 18.5 min), puerarin (retention time 22.1 min) and betaine (retention time 9.8 min) were determined by HPLC, and the total content must be ≥1.2% (w / w).

[0037] Microbiological limits: Total aerobic bacteria ≤100 CFU / g, molds and yeasts ≤10 CFU / g, Escherichia coli and Salmonella must not be detected.

[0038] Example 1: Optimization Example of Composition Based on Claim 1 This embodiment addresses the food-medicine homology composition of claim 1 by adjusting the proportions of specific components to enhance its multi-target regulatory function. The specific operation is as follows: Step 1: Raw material screening and pretreatment The core ingredients, such as corn silk, poria cocos, and kudzu root, are selected, mold or impurities are removed, and low-temperature drying technology (temperature ≤60℃) is used to retain the active ingredients. The powder is then pulverized into 80-120 mesh fine powder.

[0039] Step 2: Dynamic Compatibility Optimization According to the composition range of claim 1, the ratio of corn silk to poria cocos (1:0.6-0.8) is adjusted to enhance the synergistic effect of diuresis and dampness removal; the ratio of kudzu root to hawthorn is optimized (1:0.9-1.1), and fat-soluble and polar components are separated by gradient extraction process to ensure efficient dissolution of active substances.

[0040] Step 3: Functional Verification The effects of betaine glycosides in the composition on gut microbiota were verified through in vitro simulated gastrointestinal environment experiments, confirming their effect on promoting the production of short-chain fatty acids, while eliminating the interference of artificial additives on metabolic pathways.

[0041] Example 2: Improved preparation process based on claim 4 This embodiment focuses on the preparation process of claim 4, and improves product stability through process parameter optimization. Specific steps include: Step 1: Gradient Extraction Process The water extraction stage uses segmented temperature control (60-80℃) to avoid high temperature damage to flavonoids; the alcohol extraction stage uses 70% ethanol solution to selectively extract fat-soluble active ingredients (such as puerarin and hawthorn acid).

[0042] Step 2: Co-concentration technology After combining the water and alcohol extract filtrates, vacuum concentration (temperature ≤70℃) combined with low-temperature homogenization (pressure 20-30MPa) was used to ensure uniform particle size (≤5 μm) and prevent stratification during storage.

[0043] Step 3: Sterilization and Packaging The pasteurization process (temperature 85-90℃, time 15-20 seconds) is used in conjunction with light-proof aseptic packaging materials (oxygen permeability ≤0.5 cm³ / (m²·24h·0.1 MPa)) to extend the product shelf life to 12 months.

[0044] Example 3: Extended Example of Beverage Dosage Form Based on Claim 7 This embodiment extends the composition of claim 1 to a ready-to-drink beverage, and the specific implementation is as follows: Step 1: pH and osmotic pressure regulation The pH is adjusted to 4.5-5.5 by adding a natural buffering system (such as a citric acid-malic acid compound) to balance the taste and ingredient stability; the soluble solids content is controlled (8-12%) to avoid excessive osmotic pressure that could cause gastrointestinal irritation.

[0045] Step 2: Flavor Synergistic Design The sourness of dried plums is balanced with the natural sweetness of betaine glycosides, while the addition of mint provides a refreshing sensation, masks the bitterness of the medicinal and edible ingredients, and enhances palatability.

[0046] Step 3: Stability Test Accelerated testing (temperature 40℃, humidity 75%) verified that there was no precipitation or discoloration within 12 months, confirming the stability of the formula under high temperature and high humidity conditions.

[0047] Example 4: Granule Preparation Example Based on Claim 9 This embodiment optimizes the preparation process for the granule dosage form of claim 9: Step 1: Adhesive Selection β-cyclodextrin (1-3% addition) is used as a binder to improve particle flowability, enhance the encapsulation effect of components, and reduce oxidative loss.

[0048] Step 2: Drying process After wet granulation, dry at a low temperature of 50-60℃ to avoid high temperature damage to heat-sensitive components (such as polysaccharides and polyphenols) and ensure that the moisture content of the granules is ≤5%.

[0049] Step 3: Disintegration Performance Verification In vitro disintegration experiments confirmed that the particles completely disintegrated within 15 minutes, meeting the requirements for immediate release and facilitating rapid absorption by consumers.

[0050] Example 5: Quality control embodiment based on claim 10 This embodiment establishes the quality control standard of claim 10, and the specific method includes: Step 1: Simultaneous detection of multiple components The contents of chlorogenic acid, rutin, puerarin and betaine were determined simultaneously by HPLC. The components were efficiently separated by a gradient elution program (acetonitrile-0.1% phosphoric acid water as mobile phase), with a limit of quantitation ≤0.01%.

[0051] Step 2: Microbial Control According to GB 7101-2022 standard, the total number of aerobic bacteria (≤100 CFU / g), molds and yeasts (≤10 CFU / g) and pathogenic bacteria (not detectable) are tested to ensure product safety.

[0052] Step 3: Stability Monitoring Regularly sample and test the content of active ingredients and the integrity of packaging to confirm that the product meets the standards for all indicators within the shelf life.

[0053] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A medicinal and edible homologous composition with multi-target conditioning function and its preparation process, characterized in that: By weight, it includes the following ingredients: Corn silk 50-130 parts, Poria cocos 30-110 parts, Kudzu root 30-110 parts, Hawthorn 30-110 parts, Fried coix seed 30-100 parts, Yam 30-100 parts, Red adzuki bean 20-80 parts, Longan pulp 20-80 parts, Mulberry 20-80 parts, Mulberry leaf 20-70 parts, Lotus leaf 20-70 parts, Goji berry 20-70 parts, Rose 20-70 parts, Fried jujube seed 10-50 parts, Ligusticum striatum Combined ingredients: 10-50 parts, licorice root 10-50 parts, prepared polygonatum root 10-50 parts, stir-fried cassia seed 10-50 parts, dandelion 10-50 parts, red dates 10-50 parts, dried tangerine peel 10-35 parts, perilla leaf 10-35 parts, dried ginger 10-35 parts, amomum villosum 10-35 parts, cinnamon 10-35 parts, gardenia 10-35 parts, dried plum 50-120 parts, peppermint 30-90 parts, betaine glycosides 2-5 parts; The composition achieves its functions of regulating metabolism, improving digestive function, assisting in lipid reduction, and anti-oxidation through multi-target synergistic effects.

2. The medicinal and edible homologous composition with multi-target conditioning function and its preparation process according to claim 1, characterized in that: The weight range of each component is as follows: Corn silk 80-100 parts, Poria cocos 60-90 parts, Kudzu root 60-90 parts, Hawthorn 60-90 parts, Fried coix seed 50-80 parts, Yam 50-80 parts, Red adzuki bean 40-60 parts, Longan pulp 40-60 parts, Mulberry 40-60 parts, Mulberry leaf 40-60 parts, Lotus leaf 40-60 parts, Goji berry 40-60 parts, Rose 40-60 parts, Fried jujube seed 20-40 parts, Lily bulb 20 -40 parts, licorice 20-40 parts, prepared polygonatum 20-40 parts, stir-fried cassia seed 20-40 parts, dandelion 20-40 parts, red dates 20-40 parts, dried tangerine peel 15-25 parts, perilla leaf 15-25 parts, dried ginger 15-25 parts, amomum villosum 15-25 parts, cinnamon 15-25 parts, gardenia 15-25 parts, dried plum 80-100 parts, peppermint 50-70 parts, betaine 3-4 parts.

3. The medicinal and edible homologous composition with multi-target conditioning function and its preparation process according to claim 1 or 2, characterized in that: The proportions of the components in the composition satisfy the following synergistic relationship: The weight ratio of corn silk to Poria cocos is 1:0.6-0.8; The weight ratio of kudzu root to hawthorn is 1:0.9-1.1; The weight ratio of mulberry leaves to lotus leaves is 1:1; The ratio of the amount of betaine added to the total solids is 0.01-0.03:

1.

4. A medicinal and edible homologous composition with multi-target conditioning function and its preparation process according to any one of claims 1-3, characterized in that, Includes the following steps: Step 1: Raw material pretreatment: Wash and dry the corn silk, poria cocos, kudzu root, hawthorn, roasted coix seed, yam, red adzuki bean, longan pulp, mulberry, mulberry leaf, lotus leaf, wolfberry, rose, roasted jujube seed, lily bulb, licorice, prepared polygonatum, roasted cassia seed, dandelion, red date, dried tangerine peel, perilla leaf, dried ginger, amomum villosum, cinnamon, gardenia, dried plum, and mint separately until the moisture content is ≤8%, and grind them to 80-120 mesh; Step 2: Gradient Extraction Divide the raw materials obtained in step 1 into two groups: Group 1: Corn silk, Poria cocos, Kudzu root, Hawthorn, stir-fried Job's tears, Yam, Red adzuki bean, Longan pulp, Mulberry, Mulberry leaf, Lotus leaf, Goji berry, Rose, stir-fried jujube seed, Lily bulb, Licorice, Prepared Polygonatum rhizome, Stir-fried Cassia seed, Dandelion, Red date; The second group consists of dried tangerine peel, perilla leaves, dried ginger, cardamom, cinnamon, gardenia, dried plum, and mint. First extraction: Add 8-12 times the total weight of water, extract twice at 60-80℃ for 1-2 hours each time, and combine the filtrates; Second extraction: Add 5-8 times the total weight of 70% ethanol solution, extract at 50-60℃ for 1-1.5 hours, filter and concentrate under reduced pressure until no alcohol odor remains; Step 3: Combining and Concentrating: Combine the two sets of filtrates from Step 2 and concentrate them under a vacuum of 0.08-0.1 MPa and a temperature of 60-70℃ to a relative density of 1.10-1.20 (60℃). Step 4: Preparation and homogenization: Add betaine, stir to dissolve, and then homogenize under high pressure (pressure 20-30 MPa, temperature 50-60℃). Step 5: Sterilization and filling: Pasteurization (85-90℃, 15-20 seconds), aseptic filling.

5. The medicinal and edible homologous composition with multi-target conditioning function and its preparation process according to claim 4, characterized in that: In step 2, the material-to-liquid ratio for the first extraction group is 1:8-12 (w / v), and the material-to-liquid ratio for the second extraction group is 1:5-8 (w / v).

6. The medicinal and edible homologous composition with multi-target conditioning function and its preparation process according to claim 4, characterized in that: In step 3, the concentration temperature is 65±2℃ and the concentration time is 2-3 hours.

7. A medicinal and edible homologous composition with multi-target conditioning function and its preparation process according to any one of claims 1-3, characterized in that: The beverage has a pH value of 4.5-5.5 and a soluble solids content of 8-12%.

8. The medicinal and edible homologous composition with multi-target conditioning function and its preparation process according to claim 7, characterized in that: The beverage is packaged in light-proof aseptic bottles or aluminum foil bags, with a shelf life of ≥12 months.

9. A medicinal and edible homologous composition with multi-target conditioning function and its preparation process according to any one of claims 1-3, characterized in that: The composition can also be formulated into granules, tablets or capsules, wherein the granules have a water content of ≤5% and a disintegration time of ≤15 minutes.

10. A medicinal and edible homologous composition with multi-target conditioning function and its preparation process according to any one of claims 1-3, characterized in that: The content of chlorogenic acid, rutin, puerarin, and betaine was determined by HPLC, and the total content must be ≥1.2%.