Snake ointment as well as preparation method and application thereof

Abstract

The invention discloses snake ointment as well as a preparation method and application thereof, and relates to the technical field of daily chemical industry and medical use. The snake ointment comprises the following raw materials in parts by weight: 40-70 parts of refined snake oil, 0.05-3 parts of an antioxidant, 10-18 parts of a forming agent, 3-6 parts of a regulator, 0.1-0.3 part of a thickening stabilizer and 20-30 parts of water, and a preparation method of the refined snake oil comprises the following steps: taking out fresh fat from a snake belly, washing and cutting into blocks, carrying out ultrahigh-temperature instantaneous sterilization and enzyme deactivation, soaking in an acidic aqueous solution, washing, and drying to obtain the snake ointment. And refining the snake oil and the antioxidant composition in a frying pan, filtering and cooling to obtain crude snake oil, and carrying out short-time steam distillation treatment and cooling on the crude snake oil to obtain the snake oil. The high-quality refined snake oil is obtained by optimizing the fishy smell removal method and the oil refining method, and the refined snake oil is used for preparing the snake ointment, so that the use effect of the snake ointment can be improved.

Description

Technical Field

[0001] This invention relates to the fields of daily chemical and medical technologies, and in particular to a snake oil ointment, its preparation method, and its application. Background Technology

[0002] Snake oil is the fatty component of snakes, rich in unsaturated fatty acids such as linoleic acid and linolenic acid (up to 60% or more). It has a strong affinity and permeability to the skin and mucous membranes, and is easily absorbed by the skin. The high content of unsaturated fatty acids is key to repairing and maintaining skin health. It also contains a large number of natural active ingredients and antibacterial ingredients. Therefore, snake oil can be used to treat burns and to condition dry, wrinkled, and rough skin.

[0003] Snake oil ointment is mainly made from snake oil and some auxiliary materials. The snake oil is refined after being deodorized. Snake oil has a strong fishy smell, which mainly comes from the fishy smell produced by the degradation of certain compounds by microorganisms or endogenous enzymes, the fishy smell formed by the oxidation and decomposition of unsaturated fatty acids, and the fishy smell accumulated in the snake's body during its diet and life. The fishy smell limits the amount of snake oil that can be added to the ointment, resulting in a small amount and poor effect. Currently, deodorization methods include: steam treatment for 1-2 hours, activated carbon adsorption, and activated clay adsorption. However, activated carbon or activated clay adsorption is not very effective and will remove some unsaturated fatty acids, which will reduce the effectiveness of the snake oil. Steam treatment is effective in deodorization, but the high-temperature treatment time is long. In addition, the snake oil refining process is carried out at high temperatures, and prolonged high-temperature treatment is more likely to cause oxidation of unsaturated fatty acids in the snake oil, destroying the effective components of the snake oil. For example, patent CN 110898094 A discloses a snake oil ointment and its preparation method, which involves steam distilling snake oil under normal pressure for 2 hours and then distilling it under reduced pressure for 30 minutes to remove the fishy smell. However, due to the excessively long steam treatment time, a large amount of its effective components are destroyed. Patent CN112516198 A discloses a traditional Chinese medicine compound snake oil, its preparation method and application, which discloses that the heating temperature during the preparation of the compound snake oil is 40-200℃. Excessively high refining temperatures will lead to a large amount of destruction of the effective components.

[0004] Therefore, both the methods for refining snake oil and removing its odor need further optimization to obtain snake oil ointment with better performance. Summary of the Invention

[0005] To address the above shortcomings, this invention provides a snake oil ointment, its preparation method, and its application. The method involves deodorizing snake oil by combining ultra-high temperature instantaneous sterilization and enzyme inactivation, acidic aqueous solution treatment, and short-time steam distillation. The snake oil is then refined together with an antioxidant composition to obtain refined snake oil. This refined snake oil is used to prepare the snake oil ointment, which improves the ointment's effectiveness. The specific technical solution is as follows: A snake oil ointment comprises the following raw materials in parts by weight: 40-70 parts refined snake oil, 0.05-3 parts antioxidant, 10-18 parts forming agent, 3-6 parts regulator, 0.1-0.3 parts thickening and stabilizing agent, and 20-30 parts water; The method for preparing the refined snake oil includes the following steps: S1. Remove fresh fat from the snake's belly, wash it, peel off the surface membrane, cut it into small pieces, and sterilize and inactivate the enzymes at ultra-high temperature to obtain processed fat blocks. S2. Soak the first-processed fat block in an acidic aqueous solution for 20-30 minutes, then wash it to obtain a second-processed fat block. S3. Mix the secondary processed fat block with the antioxidant composition and pour them into the snake oil refining pot. Adjust the temperature to 80-100℃. After all the snake oil is refined, filter to remove the oil residue, cool, and obtain crude snake oil. S4. Place the crude snake oil into a steam distillation apparatus, pass steam through it for 20-30 minutes, and then cool it to obtain the refined snake oil.

[0006] Furthermore, the antioxidant is one or a combination of two of tocopherol and tea polyphenols.

[0007] Furthermore, the molding agent is one or more of beeswax, stearic acid, and carnauba wax.

[0008] Furthermore, the regulator is petrolatum or olive oil.

[0009] Furthermore, the thickening stabilizer is carbomer or xanthan gum.

[0010] Furthermore, in step S1, the ultra-high temperature instantaneous sterilization and enzyme inactivation temperature is 120-135℃, and the time is 10-15s.

[0011] Further, in step S2, the acidic aqueous solution is a mixture of citric acid or acetic acid and water in a volume ratio of (1-4):10.

[0012] Further, in step S3, the antioxidant composition is a mixture of rosemary and tocopherol, wherein the weight ratio of rosemary to tocopherol is 10:(1-3).

[0013] This invention also provides a method for preparing snake oil ointment, comprising the following steps: (1) Weigh each raw material according to the weight proportions; (2) After heating the molding agent until it melts, stop heating and add the refined snake oil and stir evenly; (3) When the temperature drops to 60-65℃, add the antioxidant, regulator, thickener and stabilizer and water, and mix and stir evenly; (4) When the temperature drops to 40-45℃, fill and cool to obtain the snake oil ointment.

[0014] This invention also provides the use of snake oil ointment in daily cosmetics or pharmaceuticals.

[0015] Compared with the prior art, the beneficial effects of the present invention are: 1. This invention removes the fishy smell from snake oil by combining ultra-high temperature instantaneous sterilization and enzyme inactivation, acidic aqueous solution treatment, and short-time steam distillation. The snake oil fat is then refined together with an antioxidant composition to obtain refined snake oil. This refined snake oil has a thorough removal of fishy odor and minimal damage to unsaturated fatty acids. Using the refined snake oil to prepare snake oil ointment can increase the amount of snake oil added to the ointment, thereby improving the moisturizing effect and skin repair effect of the ointment.

[0016] 2. In this invention, fresh snake fat is first subjected to ultra-high temperature instantaneous sterilization and enzyme inactivation. This prevents some components in the snake fat from being degraded into fishy-smelling substances under the action of microorganisms and various endogenous enzymes, thus reducing the further generation of fishy-smelling substances at the source. After sterilization and enzyme inactivation, it is treated with an acidic aqueous solution. The acidic aqueous solution can initially neutralize and precipitate some of the existing fishy-smelling substances, further reducing the content of fishy-smelling substances. Then, an antioxidant composition is added and refined at low temperature. The antioxidant composition can scavenge superoxide free radicals and chelate trace amounts of metal ions, deactivating these pro-oxidation factors and preventing the formation of more fishy-smelling substances due to lipid oxidation caused by heating. Finally, a short-time steam distillation treatment is performed to completely remove the fishy smell. Due to the multiple steps of removing the fishy smell in the early stage, a good deodorizing effect can be achieved without prolonged steam circulation during steam distillation. This also prevents the destruction of unsaturated fatty acids caused by prolonged high temperature.

[0017] 3. The refined snake oil in this invention's snake oil ointment has moisturizing and skin-repairing effects. Antioxidants prevent the unsaturated fatty acids in the snake oil from oxidizing and deteriorating. Forming agents allow the ointment to maintain a solid state at room temperature. Regulators help adjust the product's moisturizing properties and skin feel. Thickening and stabilizing agents maintain a uniform and delicate texture and increase viscosity. The combined use of refined snake oil, antioxidants, forming agents, regulators, and thickening and stabilizing agents ensures the long-term stability of the ointment's texture and composition. Detailed Implementation

[0018] The specific embodiments of the present invention will be described in detail below, but it should be understood that the scope of protection of the present invention is not limited to the specific embodiments.

[0019] Example 1 A method for preparing snake oil ointment includes the following steps: (1) Preparation of refined snake oil: Fresh fat is taken out from the belly of a cobra, washed, the surface membrane is peeled off, and it is cut into small pieces. It is sterilized and inactivated at 120°C for 15 seconds to obtain a first-processed fat block. The first-processed fat block is soaked in an acidic aqueous solution of citric acid and water in a volume ratio of 1:10 for 20 minutes, washed, and a second-processed fat block is obtained. The second-processed fat block is mixed with an antioxidant composition of rosemary and tocopherol in a weight ratio of 10:1, and then poured into a snake oil refining pot. The temperature is adjusted to 80°C. After all the snake oil is refined, the residue is filtered out and cooled to obtain crude snake oil. The crude snake oil is placed in a steam distillation apparatus and treated with steam at a water evaporation rate of 2 ml / min for 20 minutes. After cooling, refined snake oil is obtained. (2) Weigh out 40 parts refined snake oil, 0.05 parts tocopherol, 10 parts beeswax, 3 parts petrolatum, 0.1 parts carbomer and 20 parts water according to the following weight proportions; (3) After heating the beeswax until it melts, stop heating and add refined snake oil and stir well; (4) When the temperature drops to 60°C, add tocopherol, petrolatum, carbomer and water, and mix well; (5) When the temperature drops to 40°C, fill and cool to obtain snake oil ointment.

[0020] Example 2 A method for preparing snake oil ointment includes the following steps: (1) Preparation of refined snake oil: Fresh fat was taken out from the abdomen of a cobra, washed, the surface membrane was peeled off, and it was cut into small pieces. The fat was sterilized and inactivated at 135°C for 10 seconds to obtain a first-processed fat block. The first-processed fat block was soaked in an acidic aqueous solution of acetic acid and water in a volume ratio of 4:10 for 30 minutes, washed, and a second-processed fat block was obtained. The second-processed fat block was mixed with an antioxidant composition of rosemary and tocopherol in a weight ratio of 10:3, and then poured into a snake oil refining pot. The temperature was adjusted to 100°C. After all the snake oil was refined, the residue was filtered out and cooled to obtain crude snake oil. The crude snake oil was placed in a steam distillation apparatus and treated with steam at a water evaporation rate of 5 ml / min for 30 minutes. After cooling, refined snake oil was obtained. (2) Weigh out 70 parts refined snake oil, 3 parts tea polyphenols, 18 parts stearic acid, 6 parts olive oil, 0.3 parts xanthan gum and 30 parts water according to the following weight proportions; (3) Heat the stearic acid until it melts, then stop heating and add refined snake oil and stir well; (4) When the temperature drops to 65℃, add tea polyphenols, olive oil, xanthan gum and water, and mix well; (5) When the temperature drops to 45°C, fill and cool to obtain snake oil ointment.

[0021] Example 3 A method for preparing snake oil ointment includes the following steps: (1) Preparation of refined snake oil: Fresh fat was taken out from the belly of a cobra, washed, the surface membrane was peeled off, and it was cut into small pieces. The fat was sterilized and inactivated at 130°C for 12 seconds to obtain a first-processed fat block. The first-processed fat block was soaked in an acidic aqueous solution of citric acid and water in a volume ratio of 2:10 for 25 minutes, washed, and a second-processed fat block was obtained. The second-processed fat block was mixed with an antioxidant composition of rosemary and tocopherol in a weight ratio of 10:2, and then poured into a snake oil refining pot. The temperature was adjusted to 90°C. After all the snake oil was refined, the residue was filtered out and cooled to obtain crude snake oil. The crude snake oil was placed in a steam distillation apparatus and treated with steam at a water evaporation rate of 4 ml / min for 25 minutes. After cooling, refined snake oil was obtained. (2) Weigh out 66 parts refined snake oil, 1 part tocopherol, 1 part tea polyphenols, 14 parts carnauba wax, 4 parts petrolatum, 0.2 parts xanthan gum and 25 parts water according to the following weight proportions; (3) Heat the carnauba wax until it melts, then stop heating and add refined snake oil and stir well; (4) When the temperature drops to 64°C, add tocopherol, tea polyphenols, petrolatum, xanthan gum and water, and mix and stir evenly; (5) When the temperature drops to 42°C, fill and cool to obtain snake oil ointment.

[0022] Comparative Example 1: When preparing refined snake oil, ultra-high temperature instantaneous sterilization and enzyme inactivation were not performed; other steps were the same as in Example 1.

[0023] Comparative Example 2: No acidic aqueous solution treatment was performed during the preparation of refined snake oil; other steps were the same as in Example 1.

[0024] Comparative Example 3: No antioxidant composition was added during the refining of snake oil, and the other steps were the same as in Example 1.

[0025] The main odorous substances and their contents were analyzed in the refined snake oil obtained in each embodiment and comparative example. Untreated snake oil (fresh fat taken from the abdomen of a cobra and poured into a snake oil refining pot, the temperature was adjusted to 80°C, and after all the snake oil was extracted, the oil residue was removed by filtration and cooling) was used as the control group. The results are shown in Table 1. Table 1. Content of odor-causing substances in refined snake oil of each group (mg / kg) Note: "-" indicates not detected.

[0026] Table 1 shows that, compared with the reference group, the snake oil in each of the example groups contained very little of the main odorous substances. This indicates that the present invention uses a combination of ultra-high temperature instantaneous sterilization and enzyme inactivation, acidic aqueous solution treatment and short-time steam distillation to remove the odor from snake oil. Furthermore, the snake oil fat is refined together with an antioxidant composition, which can effectively reduce the content of odorous substances in snake oil and improve the user's acceptance of snake oil.

[0027] Comparative Example 4: The steam treatment time for preparing refined snake oil was 1 hour, and the other steps were the same as in Example 1.

[0028] The main active ingredients and their contents were analyzed in the refined snake oil obtained in Example 1 and Comparative Examples 3-4. The results are shown in Table 2. Table 2. Content of main active ingredients in refined snake oil of each group (g / kg) Table 2 shows that refining snake oil fat with an antioxidant composition reduces the damage to the fat caused by heating, while shortening the steam treatment time also reduces heat-induced damage to the fat. The data in Tables 1 and 2 demonstrate that the processing method of this invention can effectively remove fishy odors while minimizing the loss of unsaturated fatty acids.

[0029] The repair effect of the snake oil ointment prepared in Example 3 on sunburned skin: Case selection: 50 patients whose arms were sunburned. Inclusion criteria: Patches of bright red skin with clear borders, accompanied by a noticeable burning, stinging, or itching sensation, were selected.

[0030] Directions for use: For external use only. Apply to sunburned skin twice daily, morning and evening, for 3 consecutive days.

[0031] The skin repair effectiveness was statistically analyzed on days 1, 2, and 3. Effectiveness rate = number of effective cases / total number of cases. The results are as follows: After 1 day of use, 25 cases experienced complete disappearance of erythema, heat, pain, or itching, resulting in an effectiveness rate of 50% after 1 day; after 2 days of use, 46 cases experienced complete disappearance of erythema, heat, pain, or itching, resulting in an effectiveness rate of 92% after 2 days; and after 3 days of use, 50 cases experienced complete disappearance of erythema, heat, pain, or itching, resulting in an effectiveness rate of 100% after 3 days. This demonstrates that the snake oil ointment of this invention rapidly repairs sunburned skin.

[0032] In summary, this invention removes the fishy odor from snake oil by combining ultra-high temperature instantaneous sterilization and enzyme inactivation, acidic aqueous solution treatment, and short-time steam distillation. The snake oil fat is then refined together with an antioxidant composition to obtain refined snake oil. This refined snake oil has a thorough removal of the fishy odor and minimal damage to unsaturated fatty acids. Using the obtained refined snake oil in the preparation of snake oil ointment can increase the amount of snake oil added, thereby improving the moisturizing effect and skin repair effect of the ointment.

[0033] The foregoing description of specific exemplary embodiments of the invention is for illustrative and explanatory purposes. These descriptions are not intended to limit the invention to the precise forms disclosed, and it will be apparent that many changes and variations can be made in accordance with the foregoing teachings. The exemplary embodiments were chosen and described in order to explain the specific principles of the invention and its practical application, thereby enabling those skilled in the art to implement and utilize various different exemplary embodiments of the invention, as well as various different choices and variations. The scope of the invention is intended to be defined by the claims and their equivalents.

Claims

1. A snake oil ointment, characterized in that, The ingredients include the following parts by weight: 40-70 parts refined snake oil, 0.05-3 parts antioxidant, 10-18 parts molding agent, 3-6 parts regulator, 0.1-0.3 parts thickening and stabilizing agent, and 20-30 parts water; The method for preparing the refined snake oil includes the following steps: S1. Remove fresh fat from the snake's belly, wash it, peel off the surface membrane, cut it into small pieces, and sterilize and inactivate the enzymes at ultra-high temperature to obtain processed fat blocks. S2. Soak the first-processed fat block in an acidic aqueous solution for 20-30 minutes, then wash it to obtain a second-processed fat block. S3. Mix the secondary processed fat block with the antioxidant composition and pour them into the snake oil refining pot. Adjust the temperature to 80-100℃. After all the snake oil is refined, filter to remove the oil residue, cool, and obtain crude snake oil. S4. Place the crude snake oil into a steam distillation apparatus, pass steam through it for 20-30 minutes, and then cool it to obtain the refined snake oil.

2. The snake oil ointment according to claim 1, characterized in that, The antioxidant is one or a combination of two of tocopherol and tea polyphenols.

3. The snake oil ointment according to claim 1, characterized in that, The molding agent is one or more of beeswax, stearic acid, and carnauba wax.

4. The snake oil ointment according to claim 1, characterized in that, The regulator is petrolatum or olive oil.

5. The snake oil ointment according to claim 1, characterized in that, The thickening stabilizer is carbomer or xanthan gum.

6. The snake oil ointment according to claim 1, characterized in that, In step S1, the ultra-high temperature instantaneous sterilization and enzyme inactivation temperature is 120-135℃, and the time is 10-15s.

7. The snake oil ointment according to claim 1, characterized in that, In step S2, the acidic aqueous solution is a mixture of citric acid or acetic acid and water in a volume ratio of (1-4):

10.

8. The snake oil ointment according to claim 1, characterized in that, In step S3, the antioxidant composition is a combination of rosemary and tocopherol, wherein the weight ratio of rosemary to tocopherol is 10:(1-3).

9. A method for preparing snake oil ointment as described in any one of claims 1-8, characterized in that, Includes the following steps: (1) Weigh each raw material according to the weight proportions; (2) After heating the molding agent until it melts, stop heating and add the refined snake oil and stir evenly; (3) When the temperature drops to 60-65℃, add the antioxidant, regulator, thickener and stabilizer and water, and mix and stir evenly; (4) When the temperature drops to 40-45℃, fill and cool to obtain the snake oil ointment.

10. Use of a snake oil ointment as described in any one of claims 1-8 or a snake oil ointment prepared by the method described in claim 9 in daily cosmetics or pharmaceuticals.

Images