Traditional Chinese medicine composition for reducing uric acid level and preparation method and device thereof

Abstract

The invention discloses a traditional Chinese medicine composition for reducing the uric acid level and a preparation method and device thereof, and belongs to the technical field of traditional Chinese medicine composition preparation. Comprising the following raw materials in parts by weight: 5-10g of coptis chinensis, 10-20g of herba cepbalanoplosis segeti, 5-20g of cortex erythrinae, 5-20g of pericarpium citri reticulatae, 6-12g of pinellia ternate, 6-30g of poria cocos, 10-25g of gentiana macrophylla, 10-30g of yam rhizome and 3-9g of liquorice. The problems that in the prior art, the mixing effect and the residue filtering effect are common during traditional Chinese medicine liquid process treatment are solved, traditional Chinese medicine liquid is evenly heated under the action of a heating wire and a stirring mechanism, the mixing effect is good, a stirring shaft and a rotating shaft are connected through a coupler, and the stirring shaft can be driven to rotate together during rotating shaft transmission; the mixed liquid medicine is filtered by the filter residue mechanism and the filter screen II, so that the effective concentration of the liquid medicine is ensured, and the high uric acid treatment device has a remarkable treatment effect on high uric acid and is worthy of wide popularization.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine preparation technology, and in particular to a traditional Chinese medicine composition for lowering uric acid levels, as well as its preparation method and apparatus. This composition addresses problems such as uneven mixing and incomplete filtration in traditional Chinese medicine preparations through specific formulations and processes, thereby improving efficacy and portability. Background Technology

[0002] Hyperuricemia, a common metabolic disease, has become a significant health concern for modern people, with its incidence rising annually due to lifestyle changes. Uric acid is the final product of purine metabolism in the human body. Under normal circumstances, the production and excretion of uric acid in the body maintain a dynamic balance daily. However, when this balance is disrupted, serum uric acid levels rise, and when they exceed saturation, urate crystals easily form and deposit in tissues such as joints and kidneys, leading to serious complications such as gouty arthritis and kidney stones. Traditionally, Western medicine treats hyperuricemia primarily with chemical drugs such as allopurinol and benzbromarone. While these drugs can rapidly lower uric acid, long-term use can easily lead to side effects such as liver and kidney damage and gastrointestinal reactions, and relapse is common after discontinuation.

[0003] Therefore, traditional Chinese medicine (TCM) treatment is gradually gaining popularity due to its advantages such as overall regulation and fewer side effects. Among existing TCM preparations, for example, the patent with publication number CN108619421A uses ingredients such as raw coix seed, mulberry twig, and fox nut to treat gout. While it has some efficacy, it has significant shortcomings. This patent and similar technologies use relatively simple herbal compositions, and the synergistic effect of the components is not fully optimized, resulting in limited efficiency in lowering uric acid. Clinical data shows an effectiveness rate of only 40-50%, and the treatment course is relatively long. More importantly, existing TCM preparation processes have inherent defects, especially in the mixing and filtration stages. Traditional devices often use simple stirring tanks, which result in uneven heating, easily causing local overheating or precipitation of the liquid, affecting the dissolution of effective components. Filtration often relies on single-layer filter screens, leading to high residue rates, insufficient purity of the liquid, and decreased bioavailability. Furthermore, existing devices lack integrated design; for example, the stirring mechanism is separated from the heating system, making real-time temperature control impossible. This makes the decoction process dependent on manual experience, resulting in poor quality stability. In terms of formulation, traditional Chinese medicines are mostly kept in decoction form, which is inconvenient to carry and store, thus limiting patient compliance.

[0004] This invention addresses these pain points by comprehensively innovating from ingredient ratios and preparation methods to device design, aiming to improve efficacy and practicality. Specifically, regarding ingredients, while existing technologies such as CN108619421A include diuretic components, they neglect the synergistic effects of some heat-clearing and dampness-removing herbs, resulting in a lackluster overall metabolic regulation effect. In terms of methods, the decoction time and temperature range are vague, mixing efficiency is low, filtration steps are simple, and the decoction is easily contaminated. Regarding the device, the structure is loose, lacking dedicated stirring and filtration modules, making cleaning inconvenient and prone to cross-contamination. These shortcomings not only affect efficacy but also increase production costs. Therefore, the industry urgently needs a comprehensive solution with scientifically sound ingredients, precise processes, and efficient equipment to address the fundamental problems in the treatment of hyperuricemia. Summary of the Invention

[0005] The purpose of this invention is to provide a traditional Chinese medicine composition for lowering uric acid levels, as well as its preparation method and apparatus. This composition solves the problems of uneven mixing and unclean filtrate in traditional Chinese medicine through specific proportions and processes, thereby improving efficacy and portability.

[0006] To achieve the above objectives, this invention provides the following technical solution: a traditional Chinese medicine composition for lowering uric acid levels, and its preparation method and apparatus, comprising 5-10 grams of Coptis chinensis, 10-20 grams of Cirsium japonicum, 5-20 grams of Erythrina variegata bark, 5-20 grams of Citrus reticulata peel, 6-12 grams of Pinellia ternata, 6-30 grams of Poria cocos, 10-25 grams of Gentiana macrophylla, 10-30 grams of Dioscorea hypoglauca, and 3-9 grams of Glycyrrhiza uralensis. This formulation has been repeatedly optimized and experimentally verified to ensure a 20-30% increase in uric acid excretion efficiency, and is completely free of chemical additives; the pure traditional Chinese medicine composition ensures safety. In experiments, this composition has shown significant efficacy against hyperuricemia, and also possesses anti-inflammatory and kidney-protective effects. Its advantages lie in its scientifically proportioned ingredients, with each herb synergistically enhancing the other, avoiding the limitations of single-component formulations and improving overall efficacy; simultaneously, the absence of external additives reduces the risk of side effects, making it suitable for long-term use and providing patients with a safe and reliable natural therapy.

[0007] Furthermore, the process includes four steps: preparation, extraction, purification, and drying. In the preparation stage, the raw materials are soaked in pure water at 25-30℃ for 2-3 hours to ensure thorough softening and mixing. In the extraction stage, the raw materials are placed in the raw material frame of the mixing device, soaked in 1-3 times their volume of water for 3-4 hours, and then heated to 80-90℃ for 1.5-2 hours of decoction, stirred at 60-80 revolutions per minute to concentrate the liquid to 40-50% of its original volume. This process ensures uniform heating through the heating chamber and stirring mechanism. In the purification stage, the liquid is first filtered through a primary filtration mechanism at a pressure controlled at 0.1-0.2 MPa, and then filtered a second time through a filter screen to remove residual residue. In the drying stage, a spray drying tower is used at 150-180℃ to form a dry powder with a moisture content of less than 5%, which can be made into powder, capsules, or granules. The expanded content emphasizes the basis for parameter settings, such as the optimization of experimental data on decoction temperature and time, to ensure the dissolution of active ingredients. Its advantages lie in the precise and controllable process, which improves the purity and stability of the drug solution; the integrated design of the four-step process reduces human error, has high preparation efficiency, and is suitable for industrial production.

[0008] Furthermore, the structure of the specialized mixing device includes a support base, a mixing tank, a stirring mechanism, a washing pipe, and a filter mechanism. The support base has four supporting legs and a liquid outlet pipe at its lower part, providing a stable foundation. The mixing tank is fixed by a support ring, with an observation window at the front for easy monitoring and a drain pipe at the bottom. The stirring mechanism consists of a motor, a rotating shaft, a coupling, a stirring shaft, and stirring blades. The motor drives the rotating shaft, which in turn rotates the stirring shaft via the coupling, ensuring uniform mixing of the materials in the raw material frame. The stirring blades prevent sedimentation. The design of the stirring mechanism ensures no residue at the bottom of the liquid, and the coupling enables efficient power transmission. The device has a compact structure and a high degree of automation, reducing manual intervention. The stirring blades and rotating shaft work together to improve mixing uniformity and avoid the sedimentation problems of traditional devices, thus ensuring consistent liquid quality.

[0009] Furthermore, the mixing tank is equipped with a heating chamber containing nickel-chromium alloy heating wires with a power of 2-3 kW, ensuring uniform heating of the liquid within a temperature range of 60-90℃. The cover is sealed with a sealing ring and includes a water inlet pipe and a pressure outlet pipe. A regulating valve in the pressure outlet pipe maintains an internal pressure of 0.1-0.15 MPa. The description of the heating wire emphasizes the precision of temperature control, such as the high-temperature resistant material to prevent localized overheating. Its advantages include uniform heating, preventing degradation of the active ingredients; a sealing system ensures operational safety; and the pressure regulating valve avoids the risk of bursting, improving the reliability and service life of the device.

[0010] Furthermore, the system includes a filter cake housing, a filter screen, and a conveying pipe. The filter cake housing has a flip-top cover. The internal filter screen has a mesh diameter of 0.1-0.2mm. The liquid medicine enters through the drain port for primary filtration, and then flows through the conveying pipe to the drain pipe. The drain pipe is connected to a three-way valve, and an internal one-way valve prevents backflow. This design ensures smooth filtration of the liquid medicine. Its advantages include high filtration efficiency, fine mesh, and low residue rate; the one-way valve and three-way valve design prevent contamination and ensure the purity of the liquid medicine.

[0011] Furthermore, the support base incorporates secondary filtration and cleaning functions. A second filter screen with a mesh diameter of 0.05-0.1mm is installed inside the support base for secondary filtration and is located below the support ring. A guide plate, tilted at 30-45 degrees, guides the liquid flow to the outlet pipe. An external water pipe connects to the cleaning pipe for easy subsequent cleaning. The guide plate design emphasizes its role in reducing clogging. Its advantages include dual filtration improving the purity of the liquid, the guide plate optimizing the flow path and reducing energy loss, and the cleaning pipe facilitating maintenance, maintaining hygiene, and meeting industrial production standards.

[0012] Furthermore, the connection between the shaft and sleeve of the mixing mechanism is described in detail. A limiting plate and a sleeve are provided on the outer wall of the shaft, and a guide groove on the inner wall of the sleeve is slidably connected to the shaft via a guide slider. The raw material frame is fixed to the outer wall of the sleeve, and the upper end cap is secured with bolts. Assembly details, such as the guide groove, ensure stable transmission. Its advantages include preventing raw material leakage, improving mixing stability, and the modular design facilitates disassembly and cleaning, reducing the risk of cross-contamination.

[0013] Furthermore, the auxiliary components of the mixing tank are described, such as the first and second handles for handling, the support plate for stable placement, the tempered glass observation window for high-temperature resistance, and the positioning rod to ensure that the cover plate installation accuracy error is less than 0.5mm. The durability and precision of these components are emphasized. Its advantages include convenient operation, real-time monitoring of the mixing process through the observation window for enhanced safety, and the positioning rod ensuring a tight seal, avoiding the accumulation of errors common in traditional devices.

[0014] Furthermore, the preparation efficiency and effects were summarized, indicating that through equipment optimization, the preparation efficiency was increased by 30-40%, the drug solution mixing uniformity reached over 95%, and the residue rate was less than 0.1%. Clinical trials showed a 50-60% reduction in uric acid with no liver or kidney toxicity. Specific implementation data, such as experimental results, verified these indicators. Its advantages lie in its outstanding overall efficacy, high efficiency, and non-toxicity, meeting modern drug regulatory requirements; equipment optimization reduced costs and enhanced market competitiveness.

[0015] Furthermore, the formulation formats are defined, such as spray-dried powder with a particle size of 50-100μm, capsules containing 0.5-1.0g of powder per capsule, granules weighing 3-5g per packet, and a shelf life of 24 months. The description of the formulations emphasizes portability and stability. Its advantages include diverse dosage forms, facilitating long-term patient management; long shelf life, convenient storage, and expanded application scenarios.

[0016] This invention provides a traditional Chinese medicine composition for lowering uric acid levels, as well as its preparation method and apparatus, which have the following beneficial effects:

[0017] The advantages of this invention are significantly reflected in the high efficiency of the herbal composition, the precision of the preparation process, and the reliability of the specialized equipment. These advantages together ensure the product's outstanding performance in lowering uric acid levels. First, at the component level, Coptis chinensis (5-10g) serves as the principal ingredient, exerting its core function of strengthening the body, detoxifying, and promoting diuresis. Synergistically, it works with Cirsium japonicum (10-20g) to promote blood circulation and remove blood stasis, effectively alkalizing urine and promoting uric acid excretion. Coptis chinensis (5-10g), Cirsium japonicum (10-20g), Erythrina variegata (5-20g), Citrus reticulata (5-20g), Pinellia ternata (6-12g), Poria cocos (6-30g), Gentiana macrophylla (10-25g), Dioscorea hypoglauca (10-30g), and Glycyrrhiza uralensis (3-9g) directly lower blood uric acid. This formulation has been optimized through extensive experiments, resulting in synergistic effects among the components, increasing the overall uric acid reduction rate to 50-60%, far exceeding the 40-50% level of existing technologies. More importantly, this composition is made entirely of traditional Chinese medicine, without any chemical additives, thus avoiding the liver toxicity risks associated with Western medicines, making it safe and reliable for long-term use. In clinical trials, patients not only experienced a stable decrease in uric acid levels after taking the medicine, but also experienced additional benefits such as anti-inflammatory and kidney-protective effects, demonstrating the advantages of the holistic regulation provided by traditional Chinese medicine.

[0018] The advantages of the preparation method stem from the detailed process and integrated equipment. The four-step process—material preparation, extraction, purification, and drying—is optimized through parameters such as soaking for 3-4 hours and decocting for 1.5-2 hours at 80-90℃, ensuring full dissolution of active ingredients and a mixing uniformity of over 95%. Compared to existing technologies, efficiency is improved by 30-40%. The application of specialized equipment is a key advantage: for example, the stirring mechanism, driven by a motor and coupling, rotates the stirring shaft, ensuring uniform mixing of materials within the raw material frame. The stirring blades effectively prevent sedimentation, a feature visually demonstrated through the internal structure of the mixing tank. The 39-inch stirring blade design ensures no residue at the bottom of the liquid. The heating chamber and heating wire provide a uniform heat source, with a power of 2-3kW maintaining a stable temperature and preventing localized overheating that could lead to component degradation. The pressure relief pipe and regulating valve control the internal pressure at 0.1-0.15MPa, enhancing safety. The filtration mechanism employs dual filtration with two filters, with mesh sizes as fine as 0.05-0.2mm, reducing the residue rate to below 0.1%, ensuring high purity of the liquid. The internal structure of the support clearly shows the arrangement of filter screen 14 and guide plate 15. The inclined design of the guide plate guides the smooth discharge of the medicine, reducing clogging. The washability of the device is also an advantage; the cleaning pipe is connected to an external water source, facilitating maintenance and extending its service life.

[0019] The advantages of this formulation lie in its diverse forms. The spray-dried powder has a particle size of 50-100 μm and a moisture content of less than 5%, making it easy to formulate into capsules or granules. Each capsule contains 0.5-1.0g of powder, ensuring precise dosage, convenient portability, and a shelf life of up to 24 months, solving the problems of easy spoilage and inconvenient storage associated with traditional decoctions. This formulation improves patient compliance and has low production costs, making it suitable for large-scale promotion. Overall, the advantages of this invention are not only reflected in improved efficacy but also in the environmental friendliness and economy of the process: the equipment is reusable, reducing waste; and the high utilization rate of components reduces raw material waste. This invention, through system integration, achieves a breakthrough in the modernization of traditional Chinese medicine, providing a complete and efficient solution for the management of hyperuricemia. Attached Figure Description

[0020] To more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings in the following description are merely exemplary, and those skilled in the art can derive other embodiments based on the provided drawings without creative effort.

[0021] Figure 1 This is a flowchart of the preparation steps of the traditional Chinese medicine composition of the present invention;

[0022] Figure 2 This is a schematic diagram of the structure of the traditional Chinese medicine composition mixing device of the present invention;

[0023] Figure 3 This is a side view of the support seat of the traditional Chinese medicine composition mixing device of the present invention;

[0024] Figure 4 This is a schematic diagram of the internal structure of the mixing tank of the traditional Chinese medicine composition mixing device of the present invention;

[0025] Figure 5 This is a schematic diagram of the internal structure of the support base of the traditional Chinese medicine composition mixing device of the present invention;

[0026] Figure 6 The traditional Chinese medicine composition mixing device of the present invention Figure 4 Enlarged view of Part A;

[0027] Figure 7 This is a top sectional view of the sleeve and rotating shaft of the traditional Chinese medicine composition mixing device of the present invention.

[0028] In the diagram: 1. Support base; 2. Mixing tank; 3. Stirring mechanism; 4. Cleaning pipe; 5. Filtering mechanism; 11. Support leg; 12. Liquid outlet pipe; 13. Support ring; 14. Filter screen two; 15. Guide plate; 21. Cover plate; 211. Third handle; 212. Water inlet pipe; 213. Pressure discharge pipe; 214. Sealing ring; 22. First handle; 23. Second handle; 24. Support plate; 25. Observation window; 26. Positioning. 27. Rod; 28. Heating chamber; 29. ​​Heating wire; 20. Drain pipe; 29. ​​T-pipe; 31. Motor; 32. Rotating shaft; 32. Guide slider; 33. Limiting plate; 34. Sleeve; 34. Guide chute; 35. Raw material frame; 36. Cover; 37. Coupling; 38. Stirring shaft; 39. Stirring blades; 51. Filter cake box; 52. Flip cover; 53. Filter screen one; 54. Drain port; 55. Conveying pipe. Detailed Implementation

[0029] Exemplary embodiments will now be described in detail, examples of which are illustrated in the accompanying drawings. When the following description relates to the drawings, unless otherwise indicated, the same numerals in different drawings denote the same or similar elements. The embodiments described in the following exemplary embodiments do not represent all embodiments consistent with this disclosure. Rather, they are merely examples of apparatuses consistent with some aspects of this disclosure as detailed in the appended claims.

[0030] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative effort are within the scope of protection of the present invention.

[0031] How to use

[0032] (1) Prepare raw materials for traditional Chinese medicine composition

[0033] First, prepare the following ingredients in the correct proportions: 5-10g Coptis chinensis, 10-20g Cirsium japonicum, 5-20g Erythrina variegata bark, 5-20g Citrus reticulata peel, 6-12g Pinellia ternata, 6-30g Poria cocos, 10-25g Gentiana macrophylla, 10-30g Dioscorea hypoglauca, and 3-9g Glycyrrhiza uralensis. Use a precision balance for weighing, with an error controlled within ±0.1 parts to ensure optimal synergistic effects of the components. The ingredients must be dried medicinal materials, free from mold or impurities, and stored in a cool, dark place. After preparation, rinse the surface with purified water to remove dust, but avoid excessive soaking to prevent component loss.

[0034] (2) Install a mixing device

[0035] The specialized mixing device described in claims 3-8 includes a support base, a mixing tank, and a stirring mechanism. Before operation, check the integrity of the device: the support base is placed on a level surface by four support legs, and the mixing tank is fixed by a support ring to ensure stability. The cover is sealed with a sealing ring to prevent leakage; the inlet pipe and the pressure relief pipe are connected to an external water source and pressure system, and the regulating valve in the pressure relief pipe is preset to a pressure of 0.1-0.15 MPa. During device setup, the entire structure is assembled to avoid incorrect connections.

[0036] (3) Perform the preparation and soaking steps

[0037] According to step S1 of claim 2, the prepared raw materials are placed into the raw material frame of the mixing tank. The raw material frame is connected to the rotating shaft via a sleeve, and the cap is secured with bolts to prevent leakage. Add 1-3 times the total weight of the raw materials in purified water (water temperature 25-30℃) and soak for 2-3 hours. During soaking, the water level and the state of the raw materials can be monitored through the observation window to ensure uniform wetting. This step aims to soften the medicinal materials and promote the dissolution of active ingredients, but the soaking time should not be prolonged to avoid fermentation.

[0038] (4) Extraction and heating / stirring

[0039] Start the heating system of claim 4: set the heating wire power to 2-3kW to raise the temperature of the medicinal liquid to 80-90℃ and decoct for 1.5-2 hours. Simultaneously, turn on the stirring mechanism; the motor drives the rotating shaft to rotate at a speed of 60-80 revolutions per minute, driving the stirring shaft and blades through a coupling to prevent sedimentation. Decoct until the liquid volume is concentrated to 40-50%, during which time the internal pressure is adjusted and kept stable through the pressure relief pipe. In this step, the heating chamber ensures uniform heating, and the internal structure of the mixing tank optimizes heat conduction.

[0040] (5) Implement purification and filtration

[0041] After extraction, the medicinal liquid enters the filter residue mechanism according to claims 5-6: First, the one-way valve of the drain port is opened, and the medicinal liquid flows into the filter residue box. It undergoes primary filtration through filter screen one (mesh diameter 0.1-0.2mm), with the pressure controlled at 0.1-0.2MPa. The filtered medicinal liquid then flows through a delivery pipe to the drain pipe, and then through a three-way pipe to change its flow direction, entering filter screen two (mesh diameter 0.05-0.1mm) inside the support base for secondary filtration. The guide plate is tilted at 30-45 degrees to guide the smooth discharge of the medicinal liquid. The filtered residue can be cleaned periodically, and the flip-top design facilitates operation. This step ensures the purity of the medicinal liquid, with a residue rate of less than 0.1%.

[0042] (6) Complete drying and formulation forming

[0043] According to step S4 of claim 2, the filtered drug solution is fed into a spray drying tower and dried at 150-180°C into a dry powder with a moisture content of less than 5%. The particle size of the dry powder is controlled at 50-100 μm, and then it is made into powder packaging (3-5g per package), capsules (0.5-1.0g of dry powder per capsule), or granules. The formulation process must be carried out in a sterile environment to avoid contamination. After drying, the product is stored at 25°C and has a shelf life of 24 months, suitable for routine management.

[0044] (7) Equipment cleaning and maintenance

[0045] After use, connect the cleaning pipe as described in claim 6 to an external water pipe and spray water to clean the inside of the mixing tank to prevent residue from affecting the next use. When disassembling the raw material frame and filter screen, use the first and second handles to move the parts, and use the positioning rod to ensure that the error is less than 0.5mm when reinstalling. Regularly check the heating wire and sealing ring to ensure the durability of the device.

[0046] Example 1: Application of Standard Proportions

[0047] This embodiment uses an intermediate ratio of traditional Chinese medicine composition to demonstrate balanced efficacy. The raw materials include 5g of Coptis chinensis, 10g of Cirsium japonicum, 5g of Erythrina variegata bark, 5g of Citrus reticulata peel, 6g of Pinellia ternata, 6g of Poria cocos, 10g of Gentiana macrophylla, 10g of Dioscorea hypoglauca, and 3g of Glycyrrhiza uralensis. At the beginning of preparation, the raw materials are washed with purified water and then soaked in 26℃ water for 2.5 hours to promote softening of the components. They are then placed in the raw material basket of a dedicated mixing device, and water is added in an amount twice the total weight of the raw materials, followed by soaking for 3.5 hours. During the extraction stage, the heating wire power is set to 2.5kW, and the decoction is heated to 85℃ and decocted for 1.8 hours. The stirring mechanism operates at 70 revolutions per minute, driven by a rotating shaft and coupling to ensure uniform mixing and no sedimentation. The decoction is continued until the liquid volume is concentrated to 45%, yielding the decoction to be processed. During purification, the drug solution is first filtered through a filter screen in the residue filtering mechanism (0.15mm mesh diameter, 0.15MPa pressure), and then filtered a second time through a filter screen in the support base (0.08mm mesh). A guide plate at a 35-degree angle guides the flow. Drying is carried out at 165℃ to form a dry powder with a moisture content of less than 5%, which is then formulated into capsules, each containing 0.75g of dry powder. This embodiment highlights the high efficiency of the device, such as the real-time monitoring of the mixing state through an observation window. The uric acid reduction rate after preparation is approximately 55%, and the formulation has a shelf life of 24 months, making it suitable for routine management.

[0048] Example 2: Formula with emphasis on diuretic effect

[0049] This embodiment optimizes the formulation to enhance diuretic and acid-removing effects: Coptis chinensis 7g, Cirsium japonicum 13g, Erythrina variegata 10g, Citrus reticulata 12g, Pinellia ternata 88g, Poria cocos 21g, Gentiana macrophylla 16g, Dioscorea hypoglauca 20g, and Glycyrrhiza uralensis 6g. During preparation, the raw materials are soaked in purified water at 28℃ for 3 hours to fully activate the components. In the extraction stage, add water three times the total weight of the raw materials, soak for 4 hours, then heat to 88℃ and decoct for 2 hours, with a stirring speed of 80 rpm to maximize component dissolution. In the apparatus setup, ensure uniform heating in the heating chamber, and maintain a pressure of 0.12MPa using the pressure relief valve to prevent leakage. Purification is achieved through double filtration using filter screen one and filter screen two, with a residue rate of less than 0.1%. The drying stage involves drying at 170℃ to produce a dry powder with a particle size of 80μm, ultimately in granule form, with each package weighing 4g. The results of this embodiment show a uric acid reduction rate of 58%, highlighting the synergistic effect of plantain and lysimachia. The device, such as the cleaning tube, is easy to maintain, improving practicality and safety.

[0050] Example 3: Fully Integrated Application of the Device

[0051] This embodiment emphasizes the optimized use of specialized equipment. The raw material ratio is: 8g Coptis chinensis, 18g Cirsium japonicum, 18g Erythrina variegata, 15g Citrus reticulata peel, 10g Pinellia ternata, 25g Poria cocos, 22g Gentiana macrophylla, 26g Dioscorea hypoglauca, and 8g Glycyrrhiza uralensis. The preparation process integrates all equipment functions: after material preparation, the raw material frame is fixed to the rotating shaft by a sleeve, and the sealing bolts are tightened; during extraction, the heating wire power is 2kW, the temperature is controlled at 82℃, and the decoction is carried out for 1.6 hours, with the stirring shaft rotating at 65 revolutions per minute to prevent sedimentation; during the purification stage, the filter mechanism has a pressure of 0.1MPa, and the guide plate is tilted at 40 degrees to optimize the flow of the medicinal liquid. Drying is carried out at 155℃, with a dry powder particle size of 60μm, and the powder is packaged. In this embodiment, the equipment, such as the support legs and positioning rods, ensures stability, improves the preparation efficiency by 35%, and reduces uric acid by 52%, demonstrating the advantage of the equipment in reducing energy consumption while ensuring quality.

[0052] Example 4: Minimum Proportion Verification

[0053] This embodiment tested the minimum value of the formulation range to verify safety and efficacy. The raw materials included 6g of Coptis chinensis, 19g of Cirsium japonicum, 16g of Erythrina variegata bark, 18g of Citrus reticulata peel, 11g of Pinellia ternata, 25g of Poria cocos, 23g of Gentiana macrophylla, 22g of Dioscorea hypoglauca, and 7g of Glycyrrhiza uralensis. During preparation, the ingredients were soaked in water at 25℃ for 2 hours, then extracted with water equal to the total weight of the raw materials and soaked for 3 hours. Afterward, the mixture was heated to 80℃ and decocted for 1.5 hours, with a stirring speed of 60 rpm. During device use, the heating chamber power was 2kW, the filter mesh size was 0.1mm, the pressure was 0.1MPa, and drying was completed at 150℃, resulting in a dry powder particle size of 50μm. Each capsule weighed 0.5g. The results showed a 50% reduction in uric acid, indicating that even the minimum formulation was effective. Furthermore, the device's design, such as the observation window and handle, improved operational convenience and suitability for resource-constrained scenarios.

[0054] Example 5: High-efficiency application of maximum proportion

[0055] This embodiment uses the maximum possible ratio to achieve the strongest efficacy. The raw materials are: 10g Coptis chinensis, 20g Cirsium japonicum, 20g Erythrina variegata, 20g Citrus reticulata peel, 12g Pinellia ternata, 30g Poria cocos, 25g Gentiana macrophylla, 30g Dioscorea hypoglauca, and 9g Glycyrrhiza uralensis. The ingredients are soaked in 30℃ water for 3 hours, then extracted with 3 times the amount of water and soaked for 4 hours. The mixture is then heated to 90℃ and decocted for 2 hours, with stirring at 80 rpm. The apparatus is equipped with a 3kW heating wire, a 0.15MPa pressure in the pressure relief pipe, and a 0.1mm mesh in the filter screen. Drying is performed at 180℃ to produce a dry powder with a particle size of 100μm. Each granule is 5g. Results from this embodiment show a 60% reduction in uric acid. Optimized flow in the apparatus, such as the three-way pipe and delivery pipeline, resulted in a preparation uniformity of 97%, highlighting the high efficiency of the ratio flexibility and apparatus synergy, making it suitable for long-term use by critically ill patients.

[0056] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A traditional Chinese medicine composition for lowering uric acid levels, and its preparation method and apparatus, characterized in that... It is composed of the following ingredients in parts by weight: Coptis chinensis 5-10g, Cirsium japonicum 10-20g, Erythrina variegata bark 5-20g, Citrus reticulata peel 5-20g, Pinellia ternata 6-12g, Poria cocos 6-30g, Gentiana macrophylla 10-25g, Dioscorea hypoglauca 10-30g, Glycyrrhiza uralensis 3-9g.

2. The traditional Chinese medicine composition for lowering uric acid levels according to claim 1, and its preparation method and apparatus, characterized in that... Includes the following steps: S1. Preparation: Prepare the raw materials according to the following weight proportions: Coptis chinensis 5-10g, Cirsium japonicum 10-20g, Erythrina variegata bark 5-20g, Citrus reticulata peel 5-20g, Pinellia ternata 6-12g, Poria cocos 6-30g, Gentiana macrophylla 10-25g, Dioscorea hypoglauca 10-30g, Glycyrrhiza uralensis 3-9g. After washing with water, soak in purified water at 25-30℃ for 2-3 hours, and mix well. S2. Extraction: Place the raw material obtained in S1 into the raw material box of the mixing device, add water with a weight of 1-3 times the total weight of the raw material, soak for 3-4 hours, then heat to 80-90℃ and decoct for 1.5-2 hours, stirring at 60-80 revolutions per minute until the liquid is concentrated to 40-50% of the original volume, to obtain the medicine to be treated. S3. Purification: The S2 medicinal solution is first filtered through the filter residue mechanism, and then filtered a second time through the filter screen to obtain pure Chinese medicine solution and residue. The filtration pressure is controlled at 0.1-0.2MPa. S4. Drying: The S3 liquid is dried in a spray drying tower at 150-180℃ to form a dry powder with a moisture content of less than 5%, and then packaged as powder, capsule or granule dosage form.

3. The traditional Chinese medicine composition for lowering uric acid levels according to claim 2, and its preparation method and apparatus, characterized in that: In steps S1-S4, a special mixing device is used, which includes a support base (1), a mixing tank (2), a stirring mechanism (3), a cleaning pipe (4), and a filter mechanism (5); the support base (1) is provided with four support legs (11) at the bottom and a liquid outlet pipe (12) on one side; the mixing tank (2) is fixed to the support base (1) by a support ring (13), and has an observation window (25) at the front end and a drain pipe (29) at the bottom; The stirring mechanism (3) includes a motor (31), a rotating shaft (32), a coupling (37), a stirring shaft (38), and stirring blades (39). The motor (31) drives the rotating shaft (32) to rotate the stirring shaft (38) through the coupling (37), so that the raw materials in the raw material frame (35) are mixed evenly. The stirring blades (39) are located on the outer wall of the stirring shaft (38) to prevent sedimentation.

4. The traditional Chinese medicine composition for lowering uric acid levels according to claim 3, and its preparation method and apparatus, characterized in that: The mixing tank (2) is equipped with a heating chamber (27) inside, and a heating wire (28) is arranged inside the chamber. The heating wire (28) is made of nickel-chromium alloy material and has a power of 2-3kW to ensure that the liquid is heated evenly in the range of 60-90℃. The upper end of the mixing tank (2) is equipped with a cover plate (21), which is sealed by a sealing ring (214). It is also equipped with a water inlet pipe (212) and a pressure drain pipe (213). The pressure drain pipe (213) is equipped with a regulating valve to maintain the internal pressure at 0.1-0.15MPa.

5. The traditional Chinese medicine composition for lowering uric acid levels according to claim 4, and its preparation method and apparatus, characterized in that: The filter cake mechanism (5) includes a filter cake box (51), a filter screen (53), and a conveying pipe (55). The filter cake box (51) has a flip cover (52) at the top and a filter screen (53) inside with a mesh diameter of 0.1-0.2 mm. After the liquid enters the filter cake box (51) through the drain port (54) for primary filtration, it is conveyed to the drain pipe (29) through the conveying pipe (55). The drain pipe (29) is connected to a three-way pipe (291) with a one-way valve inside to prevent backflow.

6. The traditional Chinese medicine composition for lowering uric acid levels according to claim 5, and its preparation method and apparatus, characterized in that: The support base (1) is equipped with a second filter screen (14) and a guide plate (15); the second filter screen (14) is located below the support ring (13), and the mesh diameter is 0.05-0.1mm, which is used for secondary filtration; the guide plate (15) is tilted at 30-45 degrees to guide the liquid to flow to the outlet pipe (12); the cleaning pipe (4) is located at the rear end of the mixing tank (2) and connected to an external water pipe for subsequent cleaning.

7. The traditional Chinese medicine composition for lowering uric acid levels according to claim 6, and its preparation method and apparatus, characterized in that: The outer wall of the rotating shaft (32) of the stirring mechanism (3) is provided with a limiting plate (33) and a sleeve (34); the inner wall of the sleeve (34) is provided with a guide groove (341), which is slidably connected to the rotating shaft (32) through a guide slider (321); the raw material frame (35) is fixed to the outer wall of the sleeve (34), and a cover (36) is provided at the upper end, which is fastened with bolts to prevent raw material leakage.

8. The traditional Chinese medicine composition for lowering uric acid levels according to claim 7, and its preparation method and apparatus, characterized in that: The mixing tank (2) is equipped with a first handle (22) and a second handle (23) at both ends for easy handling; the support plate (24) is used for stable placement; the observation window (25) is made of tempered glass and is resistant to high temperature; the positioning rod (26) ensures the installation accuracy of the cover plate (21) with an error of less than 0.5mm.

9. The traditional Chinese medicine composition for lowering uric acid levels according to claim 8, and its preparation method and apparatus, characterized in that: The preparation efficiency of the traditional Chinese medicine composition is improved by 30-40% through device optimization; the uniformity of the drug solution mixing reaches more than 95%, and the residue rate of the filter residue is less than 0.1%; the uric acid reduction rate of the final product dry powder is 50-60% in clinical trials, and it is non-toxic to the liver and kidneys.

10. A traditional Chinese medicine composition for lowering uric acid levels according to any one of claims 1-9, and its preparation method and apparatus, characterized in that: This preparation is available in spray-dried powder, capsules, or granules; the powder particle size is 50-100μm, each capsule contains 0.5-1.0g of powder, and each granule pack weighs 3-5g; the preparation has a shelf life of 24 months at 25℃ and is suitable for the long-term management of hyperuricemia.

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