Preparation method of traditional Chinese medicine coptis chinensis composition electuary for reducing hypertension, hyperlipidemia and

Abstract

The invention discloses a preparation method of traditional Chinese medicine coptis chinensis composition electuary for reducing hypertension, hyperglycemia and hyperlipemia, and relates to the technical field of traditional Chinese medicine preparations, compatibility and pretreatment of raw materials are as follows: 5-15 parts by mass of coptis chinensis, 10-25 parts by mass of fried malt, 8-20 parts by mass of codonopsis pilosula, 10-25 parts by mass of hawthorn, 5-15 parts by mass of endothelium corneum gigeriae galli and 8-20 parts by mass of poria cocos are taken. The radix codonopsis and the rhizoma atractylodis macrocephalae have the effects of invigorating spleen and replenishing qi; the traditional Chinese medicine composition has a treatment effect on multiple links of obesity, such as water-dampness stagnation, gastrointestinal heat accumulation and spleen deficiency and loss of transportation; effective components with different polarities are fully extracted by a three-stage countercurrent extraction process; the product microorganism safety is guaranteed through gradient irradiation sterilization; the fluidized bed granulation ensures the uniformity and solubility of particles; the prebiotics can regulate intestinal flora and enhance the weight losing effect; the compound taste modifying system improves the taste and improves the compliance; the stability of the product is ensured by various functional auxiliary materials; clinical tests prove that the traditional Chinese medicine composition has multiple effects of losing weight, reducing blood fat, reducing blood pressure and reducing blood sugar.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine preparation technology, specifically to a method for preparing a traditional Chinese medicine Coptis chinensis composition for lowering blood pressure, blood sugar, and cholesterol levels. Background Technology

[0002] Obesity has become a global health problem, often accompanied by metabolic syndrome such as dyslipidemia, hypertension, and hyperglycemia. Currently, weight-loss products on the market mainly fall into the following categories: chemically synthesized drugs, such as orlistat and sibutramine, but these carry risks such as liver damage and cardiovascular side effects; single herbal extracts, such as rhubarb extract and lotus leaf extract, with limited effectiveness and a high risk of dependence; ordinary health supplements, with simple ingredients and a lack of systemic therapeutic effects; and meal replacement products, which are nutritionally unbalanced and difficult to maintain long-term.

[0003] Existing technologies suffer from the following shortcomings: products have limited efficacy, making it difficult to simultaneously address obesity and related metabolic abnormalities; extraction of effective components from traditional Chinese medicine is insufficient, resulting in low bioavailability; formulation processes are outdated, leading to unstable product quality; taste is poor, resulting in low patient compliance; and systematic pharmacological research and clinical validation are lacking. Therefore, developing a traditional Chinese medicine weight-loss product with comprehensive efficacy, safe use, and stable quality has significant clinical importance and market value. Summary of the Invention

[0004] To address the shortcomings of existing technologies, this invention provides a method for preparing a traditional Chinese medicine Coptis chinensis composition for lowering blood pressure, blood sugar, and cholesterol. This method solves the technical problems of existing products having single efficacy, making it difficult to simultaneously address obesity and related metabolic abnormalities; insufficient extraction of effective components from traditional Chinese medicine, resulting in low bioavailability; outdated formulation processes, leading to unstable product quality; poor taste, resulting in low patient compliance; and a lack of systematic pharmacological research and clinical validation.

[0005] To achieve the above objectives, the present invention provides the following technical solution: a method for preparing a traditional Chinese medicine Coptis chinensis composition for lowering blood pressure, blood sugar, and cholesterol, comprising the following steps: (1) Raw material compatibility and pretreatment: Take 5-15 parts of Coptis chinensis, 10-25 parts of roasted malt, 8-20 parts of Codonopsis pilosula, 10-25 parts of hawthorn, 5-15 parts of chicken gizzard lining, 8-20 parts of Poria cocos, 5-15 parts of Alisma plantago-aquatica, 8-20 parts of Atractylodes macrocephala, 10-25 parts of Coix lacryma-jobi, 5-15 parts of Polyporus umbellatus, 5-15 parts of Plantago asiatica, 3-10 parts of tomato leaves, 5-15 parts of Phellodendron chinense, 8-20 parts of Polygonatum sibiricum, 5-15 parts of Scutellaria baicalensis, 8-20 parts of Cannabis sativa, and 3-10 parts of roasted rhubarb according to the following mass proportions; After washing the medicinal materials, dry them at a low temperature of 50-60℃ until the moisture content is below 8%. (2) Sterilization of raw materials: The dried medicinal materials are sterilized by Co-60 irradiation with an irradiation dose of 6-10 kGy; (3) Ultrafine grinding: Mix the sterilized medicinal materials and grind them to a particle size of 80-120 mesh using ultrafine grinding technology to obtain uniform powder of medicinal materials; (4) Multi-stage extraction: The medicinal powder is extracted using a three-stage countercurrent extraction process, with 8-12 times the amount of water, 6-10 times the amount of 50% ethanol, and 4-8 times the amount of 70% ethanol at 60-80℃ for 1-3 hours respectively. (5) Extract treatment: Combine the extracts and concentrate them under reduced pressure at 60°C to obtain an extract with a relative density of 1.10-1.20; (6) Addition and mixing of excipients: Add the following pharmaceutical excipients to the extract: Prebiotics: 3-8 parts basilose, 5-15 parts sucrose; Filler: 20-40 parts lactose, 15-30 parts microcrystalline cellulose; Disintegrant: 5-12 parts of croscarmellose sodium cellulose, 3-8 parts of low-substituted hydroxypropyl cellulose; Wetting agent: Povidone K30 2-6 parts; Flavoring agents: 0.1-0.5 parts aspartame, 0.2-0.8 parts steviol glycosides, 0.5-2 parts citric acid; Glide aid: 1-3 parts micronized silica gel, 0.5-2 parts silica; Antioxidants: Vitamin C 0.1-0.5 parts, Vitamin E 0.05-0.3 parts; (7) Granulation and drying: The mixture is granulated into particles with a diameter of 1.0-1.5 mm using fluidized bed granulation technology, and dried at 50-60℃ until the moisture content is less than 5%; (8) Granulation packaging: After drying, the granules are sieved and granulated, and then packed into food-grade aluminum foil composite film bags at a rate of 8-12g per bag and sealed.

[0006] Preferably, the mass fractions of the raw materials mentioned in step (1) are: 8-12 parts of Coptis chinensis, 15-20 parts of roasted malt, 10-15 parts of Codonopsis pilosula, 15-20 parts of hawthorn, 8-12 parts of chicken gizzard lining, 10-15 parts of Poria cocos, 8-12 parts of Alisma plantago-aquatica, 10-15 parts of Atractylodes macrocephala, 15-20 parts of Coix lacryma-jobi, 8-12 parts of Polyporus umbellatus, 8-12 parts of Plantago asiatica, 5-8 parts of tomato leaves, 8-12 parts of Phellodendron chinense, 10-15 parts of Polygonatum sibiricum, 8-12 parts of Scutellaria baicalensis, 10-15 parts of Cannabis sativa, and 5-8 parts of roasted rhubarb.

[0007] Preferably, the irradiation sterilization in step (2) adopts gradient irradiation: first irradiate with a dose of 4-6 kGy, let stand for 12-24 hours, and then supplement irradiation with a dose of 2-4 kGy.

[0008] Preferably, the specific parameters for the three-stage countercurrent extraction in step (4) are: First stage: 10 times the amount of water, extract at 75℃ for 2 hours; Second stage: Extract with 8 times the amount of 50% ethanol at 70℃ for 1.5 hours; Third stage: Extract with 6 times the amount of 70% ethanol at 65℃ for 1 hour.

[0009] Preferably, in step (6), 1%-3% of a natural plant extract is added, which is one or more of green tea extract, lotus leaf extract or mulberry leaf extract.

[0010] Preferably, the pharmaceutical excipients in step (6) further include: Coloring agent: 0.01-0.1 parts of sodium copper chlorophyllin; Flavoring: 0.05-0.3 parts natural peppermint flavoring, 0.1-0.5 parts lemon flavoring.

[0011] Preferably, the granulation in step (7) adopts centrifugal granulation technology, with a granulation speed of 1000-1500 rpm, an inlet air temperature of 55-60℃, and an outlet air temperature of 40-45℃.

[0012] Preferably, the packaging in step (8) is done using an automatic packaging machine with a packaging speed of 40-60 bags / minute, a heat sealing temperature of 150-180℃, and a heat sealing time of 2-4 seconds.

[0013] The application of a traditional Chinese medicine Coptis chinensis composition in the preparation of a granule for treating hypertension, hyperlipidemia, and hyperglycemia.

[0014] Preferably, the granules are taken twice daily, morning and evening, one packet each time, dissolved in boiling water, for fifteen consecutive days as one course of treatment. Beneficial effects This invention provides a method for preparing a traditional Chinese medicine (TCM) Coptis chinensis (Huanglian) composition for lowering blood pressure, blood sugar, and cholesterol. This method addresses the shortcomings of existing products, such as limited efficacy, difficulty in simultaneously addressing obesity and related metabolic abnormalities, insufficient extraction of effective components, low bioavailability, outdated formulation processes, unstable product quality, poor taste, low patient compliance, and a lack of systematic pharmacological research and clinical validation. This invention offers the following advantages: Coptis chinensis is the principal herb, clearing heat and drying dampness; combined with hawthorn and roasted malt to aid digestion and relieve stagnation; and Codonopsis pilosula and Atractylodes macrocephala to strengthen the spleen and replenish qi. The synergistic effect of these herbs targets water retention, gastrointestinal heat accumulation, and spleen deficiency in obesity. The product exerts its therapeutic effect through multiple processes; a three-stage countercurrent extraction process fully extracts effective components of different polarities; gradient irradiation sterilization ensures the product's microbial safety; fluidized bed granulation ensures particle uniformity and solubility; prebiotics regulate intestinal flora and enhance weight loss effects; a compound flavoring system improves taste and increases compliance; multiple functional excipients ensure product stability; clinical trials have proven that it has multiple effects such as weight loss, lipid reduction, blood pressure reduction, and blood sugar reduction; it also improves obesity-related symptoms such as constipation and edema; all ingredients are natural, with minimal side effects; and the scientifically designed formula avoids adverse reactions such as severe diarrhea. Detailed Implementation

[0015] The present invention will be further described in detail below through specific embodiments. These embodiments are for illustrative purposes only and are not intended to limit the scope of the invention.

[0016] Example 1: A method for preparing a traditional Chinese medicine Coptis chinensis composition for lowering blood pressure, blood sugar, and cholesterol, comprising the following steps: (1) Raw material compatibility and pretreatment: Take 10 parts of Coptis chinensis, 18 parts of roasted malt, 12 parts of Codonopsis pilosula, 18 parts of hawthorn, 10 parts of chicken gizzard lining, 12 parts of Poria cocos, 10 parts of Alisma plantago-aquatica, 12 parts of Atractylodes macrocephala, 18 parts of Coix lacryma-jobi, 10 parts of Polyporus umbellatus, 10 parts of Plantago asiatica, 6 parts of tomato leaves, 10 parts of Phellodendron chinense, 12 parts of Polygonatum sibiricum, 10 parts of Scutellaria baicalensis, 12 parts of Cannabis sativa, and 6 parts of roasted rhubarb according to the following mass proportions; After washing, the medicinal materials are dried at 55℃ until the moisture content is 7.5%. (2) Sterilization treatment of raw materials: The dried medicinal materials are sterilized by Co-60 irradiation. Gradient irradiation is used, first irradiating with 5 kGy, then standing for 18 hours, and then supplementing with 3 kGy irradiation. (3) Ultrafine grinding: The sterilized medicinal materials are mixed and then ground to a particle size of 100 mesh using ultrafine grinding technology to obtain uniform powder of medicinal materials; (4) Multi-stage extraction: The herbal powder is extracted using a three-stage countercurrent extraction process, with 10 times the amount of water and 75°C for 2 hours, 8 times the amount of 50% ethanol and 70°C for 1.5 hours, and 6 times the amount of 70% ethanol and 65°C for 1 hour. (5) Extract treatment: Combine the extracts and concentrate them under reduced pressure at 60°C to a paste with a relative density of 1.15; (6) Addition and mixing of excipients: Add the following pharmaceutical excipients to the extract: 5 parts baicale, 10 parts sucrose, 30 parts lactose, 22 parts microcrystalline cellulose, 8 parts croscarmellose sodium, 5 parts low-substituted hydroxypropyl cellulose, 4 parts povidone K30, 0.3 parts aspartame, 0.5 parts steviol glycosides, 1 part citric acid, 2 parts microcrystalline silica, 1 part silicon dioxide, 0.3 parts vitamin C, 0.2 parts vitamin E, 0.05 parts sodium copper chlorophyllin, 0.2 parts peppermint flavoring, 0.3 parts lemon flavoring, plus 2% green tea extract; (7) Granulation and drying: The mixture is prepared by fluidized bed granulation technology. The granulation is carried out by centrifugal granulation technology with a granulation speed of 1200 rpm, an inlet air temperature of 58℃, an outlet air temperature of 42℃, and a particle size of 1.25 mm. The particles are dried at 55℃ until the moisture content is less than 4.5%. (8) Granulation packaging: After drying, the granules are sieved and granulated, and then packed into food-grade aluminum foil composite film bags at a rate of 10g per bag. The packaging speed is 50 bags / minute, the heat sealing temperature is 165℃, the heat sealing time is 3 seconds, and the packaging is sealed.

[0017] Example 2: A method for preparing a traditional Chinese medicine Coptis chinensis composition for lowering blood pressure, blood sugar, and cholesterol, comprising the following steps: (1) Raw material compatibility and pretreatment: Take 15 parts of Coptis chinensis, 25 parts of roasted malt, 20 parts of Codonopsis pilosula, 25 parts of hawthorn, 15 parts of chicken gizzard lining, 20 parts of Poria cocos, 15 parts of Alisma plantago-aquatica, 20 parts of Atractylodes macrocephala, 25 parts of Coix lacryma-jobi, 15 parts of Polyporus umbellatus, 15 parts of Plantago asiatica, 10 parts of tomato leaves, 15 parts of Phellodendron chinense, 20 parts of Polygonatum sibiricum, 15 parts of Scutellaria baicalensis, 20 parts of Cannabis sativa seeds, and 10 parts of roasted rhubarb according to the following mass proportions; After washing, the medicinal materials are dried at 60℃ until the moisture content is 8%. (2) Sterilization treatment of raw materials: The dried medicinal materials are sterilized by Co-60 irradiation. Gradient irradiation is used, first irradiating with 6 kGy, then standing for 24 hours, and then supplementing with 4 kGy irradiation. (3) Ultrafine grinding: The sterilized medicinal materials are mixed and then ground to a particle size of 120 mesh using ultrafine grinding technology to obtain uniform powder of medicinal materials; (4) Multi-stage extraction: The herbal powder is extracted using a three-stage countercurrent extraction process, with 12 times the amount of water and 80°C for 3 hours, 10 times the amount of 50% ethanol and 70°C for 3 hours, and 8 times the amount of 70% ethanol and 65°C for 3 hours. (5) Extract treatment: Combine the extracts and concentrate them under reduced pressure at 60°C to a paste with a relative density of 1.2; (6) Addition and mixing of excipients: Add the following pharmaceutical excipients to the extract: 8 parts baicale, 15 parts sucrose, 40 parts lactose, 30 parts microcrystalline cellulose, 12 parts croscarmellose sodium cellulose, 8 parts low-substituted hydroxypropyl cellulose, 6 parts povidone K30, 0.5 parts aspartame, 0.8 parts steviol glycosides, 2 parts citric acid, 3 parts microcrystalline silica, 2 parts silicon dioxide, 0.5 parts vitamin C, 0.3 parts vitamin E, 0.1 parts sodium copper chlorophyllin, 0.3 parts peppermint flavoring, 0.5 parts lemon flavoring, plus 3% green tea extract; (7) Granulation and drying: The mixture is prepared by fluidized bed granulation technology, and centrifugal granulation technology is used. The granulation speed is 1500 rpm, the inlet air temperature is 60℃, the outlet air temperature is 45℃, and the particle size is 1.5 mm. The particles are dried at 60℃ until the moisture content is less than 5%. (8) Granulation packaging: After drying, the granules are sieved and granulated, and then packed into food-grade aluminum foil composite film bags at a rate of 12g per bag. The packaging speed is 50 bags / minute, the heat sealing temperature is 165℃, the heat sealing time is 3 seconds, and the packaging is sealed.

[0018] Comparative Example 1: Traditional preparation method: According to the formula of Example 1, the medicinal materials were decocted in water in a conventional manner, and then granulated after simple concentration.

[0019] Comparative Example 2: Commercially available slimming tea: A certain brand of Chinese herbal slimming tea product.

[0020] Quality evaluation Physicochemical index testing Testing items Example 1 Comparative Example 1 Comparative Example 2 Particle uniformity 98.2% 85.6% 90.3% Solubility Completely dissolved Partial sedimentation Dissolves slowly Moisture content (%) 4.5 7.8 6.2 Active ingredient content (mg / g) 15.8±1.1 8.2±2.3 6.5±1.8 Stability test Accelerated testing for 6 months at 40℃ and 75% relative humidity: Example 1: No change in appearance, effective ingredient retention rate 95.8%; Comparative Example 1: Clumping occurred, effective ingredient retention rate 76.3%; Comparative Example 2: Color darkened, effective ingredient retention rate 82.5%.

[0021] Clinical efficacy observation 180 obese patients (BMI≥28) were randomly divided into three groups: Example 1 group: took the granules of the present invention twice a day; Comparative Example 1 group: took the traditionally prepared product twice a day; Comparative Example 2 group: took commercially available slimming tea twice a day. Observe the efficacy after 12 weeks of treatment: Group Number of examples Weight loss (kg) Waist circumference decreased (cm) Overall efficiency BMI declines Example 1 60 8.5±2.3 7.8±1.9 91.7% 3.2±0.8 Comparative Example 1 60 4.2±1.8 4.1±1.5 68.3% 1.6±0.6 Comparative Example 2 60 5.8±2.1 5.3±1.7 75.0% 2.2±0.7 Improved metabolic indicators detection indicators Improvement rate in Example 1 Comparative Example 2 Improvement Rate Total cholesterol 28.5% 15.3% Triglycerides 35.2% 18.7% fasting blood glucose 22.8% 12.4% systolic blood pressure 18.6% 10.2% Safety assessment The incidence of adverse reactions in Group 1 of Example 1 was 8.3%, mainly manifested as mild diarrhea; The incidence of adverse reactions in the comparative group 1 was 16.7%, including abdominal pain and nausea; The incidence of adverse reactions in the comparative group 2 was 13.3%.

[0022] Patient satisfaction survey The survey considered factors such as effectiveness, taste, and ease of use. Example 1: Group satisfaction rate was 92%; Comparative group 1 had a satisfaction rate of 70%; The satisfaction rate of the two control groups was 78%.

[0023] This invention, through scientific raw material formulation and advanced preparation technology, has successfully developed a comprehensive and safe traditional Chinese medicine (TCM) Coptis chinensis (Huanglian) composition for the treatment of obesity. Compared with traditional methods, this invention's product has significant advantages in terms of quality stability, efficacy, and ease of use. In particular, it shows better improvement in obesity and related metabolic abnormalities, providing obese patients with a high-quality treatment option.

[0024] It should be noted that in this paper, relational terms such as first and second are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations.

Claims

1. A method for preparing a traditional Chinese medicine Coptis chinensis composition for lowering blood pressure, blood sugar, and cholesterol, characterized in that, Includes the following steps: (1) Raw material compatibility and pretreatment: Take 5-15 parts of Coptis chinensis, 10-25 parts of roasted malt, 8-20 parts of Codonopsis pilosula, 10-25 parts of hawthorn, 5-15 parts of chicken gizzard lining, 8-20 parts of Poria cocos, 5-15 parts of Alisma plantago-aquatica, 8-20 parts of Atractylodes macrocephala, 10-25 parts of Coix lacryma-jobi, 5-15 parts of Polyporus umbellatus, 5-15 parts of Plantago asiatica, 3-10 parts of tomato leaves, 5-15 parts of Phellodendron chinense, 8-20 parts of Polygonatum sibiricum, 5-15 parts of Scutellaria baicalensis, 8-20 parts of Cannabis sativa, and 3-10 parts of roasted rhubarb according to the following mass proportions; After washing the medicinal materials, dry them at a low temperature of 50-60℃ until the moisture content is below 8%. (2) Sterilization treatment of raw materials: The dried medicinal materials are sterilized by Co-60 irradiation with an irradiation dose of 6-10 kGy; (3) Ultrafine grinding: Mix the sterilized medicinal materials and grind them to a particle size of 80-120 mesh using ultrafine grinding technology to obtain uniform powder of medicinal materials; (4) Multi-stage extraction: The medicinal powder is extracted using a three-stage countercurrent extraction process, with 8-12 times the amount of water, 6-10 times the amount of 50% ethanol, and 4-8 times the amount of 70% ethanol extracted at 60-80℃ for 1-3 hours respectively. (5) Extract treatment: Combine the extracts and concentrate them under reduced pressure at 60°C to a paste with a relative density of 1.10-1.20; (6) Addition and mixing of excipients: Add the following pharmaceutical excipients to the extract: Prebiotics: 3-8 parts basilose, 5-15 parts sucrose; Filler: 20-40 parts lactose, 15-30 parts microcrystalline cellulose; Disintegrant: 5-12 parts of croscarmellose sodium cellulose, 3-8 parts of low-substituted hydroxypropyl cellulose; Wetting agent: Povidone K30 2-6 parts; Flavoring agents: 0.1-0.5 parts aspartame, 0.2-0.8 parts steviol glycosides, 0.5-2 parts citric acid; Glide aid: 1-3 parts micronized silica gel, 0.5-2 parts silica; Antioxidants: Vitamin C 0.1-0.5 parts, Vitamin E 0.05-0.3 parts; (7) Granulation and drying: The mixture is granulated into particles with a diameter of 1.0-1.5 mm using fluidized bed granulation technology, and dried at 50-60℃ until the moisture content is less than 5%; (8) Granulation packaging: After drying, the granules are sieved and granulated, and then packed into food-grade aluminum foil composite film bags at a rate of 8-12g per bag and sealed.

2. The method for preparing a traditional Chinese medicine Coptis chinensis composition for lowering blood pressure, blood sugar, and cholesterol as described in claim 1, characterized in that, The mass fractions of the raw materials mentioned in step (1) are as follows: Coptis chinensis 8-12 parts, roasted malt 15-20 parts, Codonopsis pilosula 10-15 parts, hawthorn 15-20 parts, chicken gizzard lining 8-12 parts, Poria cocos 10-15 parts, Alisma plantago-aquatica 8-12 parts, Atractylodes macrocephala 10-15 parts, Coix lacryma-jobi 15-20 parts, Polyporus umbellatus 8-12 parts, Plantago asiatica 8-12 parts, tomato leaves 5-8 parts, Phellodendron chinense 8-12 parts, Polygonatum sibiricum 10-15 parts, Scutellaria baicalensis 8-12 parts, Cannabis sativa 10-15 parts, and roasted rhubarb 5-8 parts.

3. The method for preparing a traditional Chinese medicine Coptis chinensis composition for lowering blood pressure, blood sugar, and cholesterol as described in claim 1, characterized in that, The irradiation sterilization described in step (2) adopts gradient irradiation: first, irradiate with a dose of 4-6 kGy, let stand for 12-24 hours, and then supplement with a dose of 2-4 kGy.

4. The method for preparing a traditional Chinese medicine Coptis chinensis composition for lowering blood pressure, blood sugar, and cholesterol as described in claim 1, characterized in that, The specific parameters for the three-stage countercurrent extraction described in step (4) are as follows: First stage: 10 times the amount of water, extract at 75℃ for 2 hours; Second stage: Extract with 8 times the amount of 50% ethanol at 70℃ for 1.5 hours; Third stage: Extract with 6 times the amount of 70% ethanol at 65℃ for 1 hour.

5. The method for preparing a traditional Chinese medicine Coptis chinensis composition for lowering blood pressure, blood sugar, and cholesterol as described in claim 1, characterized in that, In step (6), 1%-3% of the total mass of the final product is added of natural plant extracts, which are one or more of green tea extract, lotus leaf extract or mulberry leaf extract.

6. The method for preparing a traditional Chinese medicine Coptis chinensis composition for lowering blood pressure, blood sugar, and cholesterol as described in claim 1, characterized in that, The pharmaceutical excipients mentioned in step (6) also include: Coloring agent: 0.01-0.1 parts of sodium copper chlorophyllin; Flavoring: 0.05-0.3 parts natural peppermint flavoring, 0.1-0.5 parts lemon flavoring.

7. The method for preparing a traditional Chinese medicine Coptis chinensis composition for lowering blood pressure, blood sugar, and cholesterol as described in claim 1, characterized in that, The granulation process described in step (7) uses centrifugal granulation technology with a granulation speed of 1000-1500 rpm, an inlet air temperature of 55-60℃, and an outlet air temperature of 40-45℃.

8. The method for preparing a traditional Chinese medicine Coptis chinensis composition for lowering blood pressure, blood sugar, and cholesterol as described in claim 1, characterized in that, The packaging described in step (8) uses an automatic packaging machine with a packaging speed of 40-60 bags / minute, a heat sealing temperature of 150-180℃, and a heat sealing time of 2-4 seconds.