Hymexazol and sodium trichloroisocyanurate compounded bactericidal composition and application thereof

Abstract

The invention discloses a hymexazol and sodium trichloroisocyanurate compounded bactericidal composition, which takes hymexazol and sodium trichloroisocyanurate as main active ingredients, and the mass ratio of hymexazol to sodium trichloroisocyanurate is (1: 1)-(200: 1); the bactericidal composition further comprises 1, 3-propane sultone; the ratio of the total amount of hymexazol and sodium trichloroisocyanurate to the mass of 1, 3-propane sultone is (30: 1)-(90: 1). The invention also discloses application of the bactericidal composition in prevention and treatment of downy mildew, fusarium wilt, damping off and black spot of plants. Compared with a single agent of hymexazol, the bactericidal composition provided by the invention can improve the problem that hymexazol is easy to generate resistance, and widens the application range of the agent. The bactericide composition can replace some high-toxicity bactericides, the dosage is reduced, the environment is protected, and meanwhile pesticide residues are reduced. According to the invention, 1, 3-propane sultone is used as a synergist, so that the pesticide effect is enhanced.

Description

Technical Field

[0001] This invention belongs to the field of pesticides, specifically relating to a bactericidal composition of oxadixyl and sodium trichloroisocyanurate and its application. Background Technology

[0002] Oxythiamethoxam is a systemic, highly effective fungicide, soil disinfectant, and plant growth regulator. It possesses unique efficacy, exhibiting high efficiency, low toxicity, and environmental friendliness, making it a high-tech, eco-friendly product. Oxythiamethoxam effectively inhibits the normal growth of pathogenic fungal mycelium or directly kills pathogens, while also promoting plant growth, including root development, strong seedlings, and increased crop survival rates. Oxythiamethoxam has extremely high penetration; it can reach the stem within two hours and the entire plant within 20 hours.

[0003] Sodium trichloroisocyanurate is a white crystalline powder and available in various shapes. When dissolved in water, it undergoes hydrolysis, releasing sodium hypochlorite, thus possessing bleaching, bactericidal, and chlorinating properties. It exhibits excellent killing effects against various bacteria and algae. It has highly efficient, broad-spectrum, and relatively safe disinfection effects, killing bacteria, viruses, fungi, spores, and also showing some killing effect on coccidia oocysts.

[0004] Synergists are crucial for enhancing the efficacy of agrochemicals. However, the mechanisms by which synergists work in fungicides are complex. The use of synergists introduces another factor into the interactions between fungi, fungicides, and host / plant plants.

[0005] Today, with the increasing demand for fruits and vegetables, the planting area is also constantly expanding. Consequently, the affected area and severity of diseases such as downy mildew, wilt, and damping-off are also increasing, making prevention and control more difficult. At the same time, pathogen resistance is constantly strengthening. Furthermore, to protect the environment, highly toxic pesticides cannot be used, posing a significant challenge to the control of plant and fruit disease. Summary of the Invention

[0006] To address the shortcomings of existing technologies, the present invention aims to provide a fungicide composition combining oxadixyl and sodium trichloroisocyanurate, with 1,3-propanesulfonic acid as a synergist to achieve a synergistic effect. This fungicide composition has significant control effects on plant diseases such as downy mildew, damping-off, wilt, and black spot.

[0007] The objective of this invention is achieved through the following technical solution:

[0008] A bactericidal composition of oxamyl and sodium trichloroisocyanurate, wherein the bactericidal composition uses oxamyl and sodium trichloroisocyanurate as the main active ingredients, and the mass ratio of oxamyl to sodium trichloroisocyanurate is 1:1 to 200:1.

[0009] Preferably, the mass ratio of oxamyl to sodium trichloroisocyanurate is 1:1 to 4:1.

[0010] Preferably, the mass ratio of oxamyl to sodium trichloroisocyanurate is 60:1 to 200:1.

[0011] More preferably, the mass ratio of oxamyl to sodium trichloroisocyanurate is 80:1 to 200:1.

[0012] Specifically, the mass ratio of oxamyl to sodium trichloroisocyanurate is 1:1, 2:1, 2.2:1, 3:1, 4:1, 5:1, 10:1, 15:1, 20:1, 25:1, 30:1, 35:1, 40:1, 50:1, 60:1, 70:1, 80:1, 90:1, 100:1, 150:1, or 200:1.

[0013] As a preferred embodiment of the bactericidal composition of oxamyl and sodium trichloroisocyanurate described in this invention, the bactericidal composition further includes 1,3-propanesulfonate lactone as a synergist; the total amount of oxamyl and sodium trichloroisocyanurate and the mass ratio of 1,3-propanesulfonate lactone are 30:1 to 90:1.

[0014] Specifically, the total amount of oxamyl and sodium trichloroisocyanurate and the mass ratio of 1,3-propanesulfonate lactone can be 30:1, 70:1, 80:1, 64:1, 60:1, or 90:1.

[0015] The aforementioned bactericidal composition of hymexazol and sodium trichloroisocyanurate uses hymexazol and sodium trichloroisocyanurate as the main active ingredients, 1,3-propanesulfonate lactone as a synergist, and is compounded with known adjuvants, fillers or solvents to form any pesticide formulation permitted by law.

[0016] The total content of oxamyl and sodium trichloroisocyanurate is 25% to 80% by mass percentage, and the content of 1,3-propanesulfonate lactone is 0.2% to 1%, and the mass ratio of oxamyl and sodium trichloroisocyanurate, the total amount of oxamyl and sodium trichloroisocyanurate, and the mass ratio of 1,3-propanesulfonate lactone meet the aforementioned requirements.

[0017] The additive is at least one of the following: wetting agent, dispersant, binder, disintegrant, antifreeze, and defoamer.

[0018] The formulation of the bactericidal composition of oxamyl and sodium trichloroisocyanurate is an aqueous suspension or a wettable powder.

[0019] Another object of the present invention is to provide a wettable powder made of the following components in weight percentages: 25% to 80% of the total amount of oxamyl and sodium trichloroisocyanurate, 2% to 8% of the wetting agent, 2% to 10% of the dispersant, 0.2% to 1% of 1,3-propanesulfonate lactone, and the remainder being fillers; and the mass ratio of oxamyl to sodium trichloroisocyanurate, the total amount of oxamyl to sodium trichloroisocyanurate, and the mass ratio of 1,3-propanesulfonate lactone meet the aforementioned requirements.

[0020] As a preferred embodiment of the wettable powder described in this invention, 1,3-propanesulfonate lactone is added during mixing.

[0021] The wetting agent is selected from at least one of sodium dodecyl sulfate, sodium dodecylbenzene sulfonate, butyl naphthalene sulfonate, and alkyl naphthalene sulfonate.

[0022] The alkylnaphthalene sulfonate may be selected from sodium alkylnaphthalene sulfonate.

[0023] The dispersant is selected from at least one of lignin sulfonate, naphthalene sulfonate, and polycarboxylate. The lignin sulfonate may be selected from calcium lignin sulfonate; the naphthalene sulfonate may be selected from sodium 1-naphthalene sulfonate.

[0024] The filler is selected from at least one of light calcium carbonate, calcined kaolin, corn starch, and maltodextrin.

[0025] Another object of the present invention is to provide an aqueous suspension made of the following components in the following mass percentages: 25% to 80% of the total amount of oxamyl and sodium trichloroisocyanurate, 2% to 8% of the wetting agent, 2% to 10% of the dispersant, 0.10% to 0.65% of the thickener, 4% to 6% of the antifreeze, 0% to 5% of the binder, 0% to 5% of the disintegrant, 0.3% to 1% of the defoamer, 0.2% to 1% of the 1,3-propanesulfonate lactone, and the remainder being water; and the mass ratio of oxamyl to sodium trichloroisocyanurate, the total amount of oxamyl to sodium trichloroisocyanurate, and the mass ratio of 1,3-propanesulfonate lactone meet the aforementioned requirements.

[0026] Preferably, the aqueous suspension is made of the following components in the indicated mass percentages: 25%–45% of the total amount of oxadixyl and sodium trichloroisocyanurate, 2%–8% of the wetting agent, 6%–8% of the dispersant, 0.6%–0.65% of the thickener, 4%–6% of the antifreeze, 0%–5% of the binder, 0.3%–1% of the defoamer, 0.2%–1% of 1,3-propanesulfonate lactone, and the remainder being water.

[0027] The wetting agent is selected from at least one of sodium dodecyl sulfate, sodium dodecylbenzene sulfonate, butyl naphthalene sulfonate, and alkyl naphthalene sulfonate.

[0028] The alkylnaphthalene sulfonate may be selected from sodium alkylnaphthalene sulfonate.

[0029] The dispersant is selected from at least one of lignin sulfonate, naphthalene sulfonate, carboxylate, and polycarboxylate.

[0030] The thickener is selected from a combination of xanthan gum and magnesium aluminum silicate in a mass ratio of 1:2 to 1:2.5.

[0031] The antifreeze is selected from one of ethylene glycol, propylene glycol, and glycerol.

[0032] The binder is selected from at least one of maltodextrin and starch.

[0033] The disintegrant is selected from at least one of silicon-low substituted hydroxypropyl cellulose, sodium carboxymethyl starch, urea, and ammonium sulfate.

[0034] The defoamer is selected from at least one of polyethylene glycol fatty acids, tributyl phosphate, and silicone defoamers. The silicone defoamer is selected from silicone defoamer S-29.

[0035] Another object of the present invention is to provide a method for preparing the aforementioned aqueous suspension, comprising: mixing oxamyl, sodium trichloroisocyanurate, wetting agent, and magnesium aluminum silicate evenly to obtain a solid material; taking water accounting for 60% to 85% of the total amount, mixing it with a dispersant, adding an antifreeze and a defoamer, then mixing it evenly with the solid material, stirring, milling, filtering, adding xanthan gum aqueous solution and 1,3-propanesulfonate lactone, stirring, and obtaining an aqueous suspension.

[0036] Another object of the present invention is to provide the application of the aforementioned bactericidal composition in the prevention and control of plant diseases such as downy mildew, wilt, damping-off, and black spot.

[0037] The downy mildew described is caused by *Pseudomonas columbarum*.

[0038] Preferably, the bactericidal composition is used in the prevention and control of watermelon downy mildew and wheat black spot.

[0039] The beneficial effects of this invention are as follows:

[0040] (1) The bactericidal composition of the present invention has the ability to synergistically enhance the effect. Compared with oxamyl alone, the bactericidal composition of the present invention can improve the problem of oxamyl easily developing resistance, has a good bactericidal effect, fast bactericidal speed, good safety to crops, and broadens the scope of application of the agent.

[0041] (2) The fungicide composition of the present invention can replace some highly toxic fungicides, reduce the amount of pesticide used, protect the environment, and reduce pesticide residues.

[0042] (3) The bactericide composition of the present invention uses 1,3-propanesulfonate lactone as a synergist to enhance the efficacy. Detailed Implementation

[0043] The technical solutions and effects of the present invention will be further described below with reference to specific embodiments. It should be understood that the following embodiments are merely preferred embodiments of the present invention and are only used to illustrate and explain the present invention, and are not intended to limit the scope of the present invention. Those skilled in the art can still modify the technical solutions described in the embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

[0044] In the following examples, unless otherwise specified, the pharmaceuticals and raw materials are all derived from commercially available conventional products or products obtained by conventional methods.

[0045] Example 1

[0046] 30% Hymexazol-Sodium Trichloroisocyanurate Wettable Powder

[0047] Take 15g of oxamyl, 15g of sodium trichloroisocyanurate, 6g of sodium dodecyl sulfate, 8g of calcium lignosulfonate, and 56g of light calcium carbonate. Mix the above raw materials evenly and then pulverize them with ultra-fine airflow to obtain fine powder with a particle size D. 50 It is 11.382 μm, D 90 The value is 18.452 μm, which corresponds to 30% oxadixyl-sodium trichloroisocyanurate wettable powder. Add 1 g of 1,3-propanesulfonate lactone during drum mixing.

[0048] Example 2

[0049] 70% Hymexazol-Sodium Trichloroisocyanurate Wettable Powder

[0050] Take 48g of oxadixyl, 22g of sodium trichloroisocyanurate, 8g of sodium alkylnaphthalene sulfonate, 10g of calcium lignosulfonate, and 12g of calcined kaolin. Mix the above raw materials evenly and then pulverize them with ultra-fine airflow to obtain fine powder with a particle size D. 50 It is 11.422 μm, D 90 The value is 16.482 μm, which corresponds to 70% oxadixyl-sodium trichloroisocyanurate wettable powder. Add 1 g of 1,3-propanesulfonate lactone during drum mixing.

[0051] Example 3

[0052] 80% Hymexazol-Sodium Trichloroisocyanurate Wettable Powder

[0053] Take 60g of oxadixyl, 20g of sodium trichloroisocyanurate, 6g of sodium dodecylbenzenesulfonate, 5g of polycarboxylate dispersant 5040 (Hubei Xinyuhong), and 9g of maltodextrin. Mix the above raw materials evenly and then pulverize them with ultra-fine airflow to obtain fine powder with a particle size D. 50 It is 12.462 μm, D 90 The thickness is 17.756 μm, which corresponds to 80% oxadixyl-sodium trichloroisocyanurate wettable powder. Add 1 g of 1,3-propanesulfonate lactone during drum mixing.

[0054] Example 4

[0055] 64% Hymexazol-Sodium Trichloroisocyanurate Wettable Powder

[0056] Take 48g of oxamyl, 16g of sodium trichloroisocyanurate, 8g of sodium alkylnaphthalenesulfonate, 8g of sodium 1-naphthalenesulfonate, and 20g of light calcium carbonate. Mix the above raw materials evenly and then pulverize them with ultra-fine airflow to obtain fine powder with a particle size D. 50 It is 11.882 μm, D 90 The value is 18.542 μm, which corresponds to 64% oxadixyl-sodium trichloroisocyanurate wettable powder. Add 1 g of 1,3-propanesulfonate lactone during drum mixing.

[0057] Example 5

[0058] 30% Oxyphenidyl-Sodium Trichloroisocyanurate Aqueous Suspension

[0059] Take 15g of oxamyl, 15g of sodium trichloroisocyanurate, 6g of sodium dodecylbenzenesulfonate, and 0.45g of magnesium aluminum silicate (thickener), and mix the above raw materials evenly to obtain a solid material; dissolve 8g of 1-benzylpyridine-3-carboxylate (CAS No.: 15990-43-9) in 39.6g of water, add 6g of glycerol (antifreeze) and 0.45g of organosilicon defoamer S-29, and then mix them evenly with the solid material, stir, mill, filter, add 9g of xanthan gum aqueous solution (thickener) with a mass fraction of 2% and 0.5g of 1,3-propanesulfonate lactone, stir, and obtain a 15% oxamyl + 15% sodium trichloroisocyanurate aqueous suspension.

[0060] Example 6

[0061] 45% Oxyphenidyl-Sodium Trichloroisocyanurate Aqueous Suspension

[0062] Take 30g of oxamyl, 15g of sodium trichloroisocyanurate, 6g of sodium dodecylbenzenesulfonate, and 0.45g of magnesium aluminum silicate (thickener), and mix the above raw materials evenly to obtain a solid material; take 6g of polycarboxylate dispersant 7023A (Wuxi Yijingfeng Technology Co., Ltd.), add 26.6g of water, then add 6g of glycerin (antifreeze) and 0.45g of organosilicon defoamer S-29, mix evenly with the solid material, stir, mill, filter, add 9g of xanthan gum aqueous solution (thickener) with a mass fraction of 2% and 0.5g of 1,3-propanesulfonate lactone, stir, and obtain a 30% oxamyl + 15% sodium trichloroisocyanurate aqueous suspension.

[0063] Example 7

[0064] 30% Hymexazol-Sodium Trichloroisocyanurate Wettable Powder

[0065] Take 15g of oxadixyl, 15g of sodium trichloroisocyanurate, 6g of sodium dodecyl sulfate, 8g of calcium lignosulfonate, and 56g of light calcium carbonate. Mix the above raw materials evenly and then pulverize them with ultra-micro airflow to obtain a fine powder, which is 30% oxadixyl-sodium trichloroisocyanurate wettable powder. Add 1g of organosilicon synergist 380 (Nanjing Teslon Technology Co., Ltd.) during tank mixing.

[0066] Example 8

[0067] To verify the actual effect of the bactericidal composition of the present invention, the following is a description based on specific experiments.

[0068] I. Indoor Life Test

[0069] Experimental methods

[0070] Pseudoperonospora cubensis was used as the experimental subject, and indoor bioassays were conducted in accordance with the "Guidelines for Indoor Bioassays of Pesticides NY / T1156.7-2006".

[0071] Select pathogenic leaves, wash off sporangia of *Pseudomonas cucumeris* from the underside of the leaves with 4℃ distilled water, prepare a suspension, and store at 4℃.

[0072] Multiple agents of different concentrations were designed, and the solutions were evenly sprayed onto both sides of watermelon leaves. After air drying for 24 hours, spore suspensions were inoculated onto the leaves. Following inoculation, the leaves were cultured for 5 days under alternating light / dark conditions (12 hours per day) at 20℃ and 90% relative humidity. The leaves were graded based on the disease incidence in the blank control. The EC50 of each agent was calculated. 50 The Sun Yunpei method was used to calculate the toxicity index TI, actual toxicity index ATI, theoretical toxicity index TTI, and co-toxicity coefficient CTC.

[0073] Table 1. Results of in vitro bioassays of *Pseudomonas cocovenenans* at different mass ratios of oxamyl and sodium chloroisocyanurate.

[0074]

[0075]

[0076] As shown in Table 1, when the mass ratio of oxamyl to sodium trichloroisocyanurate is 1:1 to 200:1, the co-toxicity coefficient (CTC) against *Peronospora cubuli* is greater than 120, indicating that the combination of the two within this mass ratio range exhibits a synergistic effect against *Peronospora cubuli*. When the mass ratio of oxamyl to sodium trichloroisocyanurate is 60:1 to 200:1, especially 80:1 to 200:1, the synergistic effect is even more significant.

[0077] II. Field efficacy experiment

[0078] Six experimental groups and ten control groups were set up. Experimental groups 1 to 6 used the formulations prepared in Examples 1 to 6, respectively. Control groups 1 to 6 used the formulations prepared in Examples 1 to 6 but without the addition of 1,3-propanesulfonate lactone (using water or filler in the corresponding examples instead of 1,3-propanesulfonate lactone). Control group 7 used the formulation prepared in Example 7. Control group 8 was a blank control group. Control group 9 used 30% hymexazol aqueous solution. Control group 10 used 38% sodium trichloroisocyanurate disinfectant tablets as solvent.

[0079] A field efficacy experiment was conducted against watermelon downy mildew. Sixteen treatment plots were established, with each treatment replicated three times. A second application was performed seven days after the first. Fifteen days after treatment, random sampling was used to collect samples from four points (east, south, west, and north) in each plot, with two plants surveyed at each point, for a total of eight plants. Disease severity was investigated and recorded using the following grading method:

[0080] Level 0: No disease;

[0081] Grade 1: The area of ​​lesions accounts for less than 5% of the total leaf area;

[0082] Grade 3: The lesion area accounts for 6% to 10% of the total leaf area;

[0083] Level 5: The lesion area accounts for 11% to 25% of the total leaf area;

[0084] Level 7: The lesion area accounts for 26% to 50% of the total leaf area;

[0085] Level 9: The lesion area accounts for more than 50% of the total leaf area.

[0086] Disease index = [∑(number of diseased leaves at each level × relative level value)] / (total number of leaves surveyed × 9) × 100

[0087] Prevention and control efficacy (%) = (Disease index of blank control - Disease index of drug treatment) / Disease index of blank control × 100

[0088] Table 2. Control efficacy of watermelon downy mildew.

[0089] Experimental Examples Dosage (based on active ingredient in g / mu) Downy mildew control rate Control group 1 300 79.63％ Control group 2 300 78.21％ Control group 3 300 80.56％ Control group 4 300 80.94％ Control group 5 300 79.37％ Control group 6 300 81.42％ Experimental group 1 300 85.17％ Experimental group 2 300 85.67％ Experimental group 3 300 91.65％ Experimental group 4 300 90.13％ Experimental group 5 300 86.81％ Experimental group 6 300 89.31％ Control group 7 300 82.40％ control group 8 —— 50.13％ Control group 9 300 77.34％ control group 10 300 70.82％

[0090] As shown in Table 2, compared with the formulation without synergist, the efficacy of the formulation with oxamoxetine and sodium trichloroisocyanurate as active ingredients was significantly improved after the addition of 1,3-propanesulfonate lactone; and compared with the formulation with organosilicon synergist, the efficacy of the formulation containing oxamoxetine and sodium trichloroisocyanurate was also significantly improved after the addition of 1,3-propanesulfonate lactone.

Claims

1. A bactericidal composition of oxamyl and sodium trichloroisocyanurate, characterized in that: The bactericidal composition uses oxamyl and sodium trichloroisocyanurate as the main active ingredients, and the mass ratio of oxamyl to sodium trichloroisocyanurate is 1:1 to 200:

1.

2. The bactericidal composition of oxamyl and sodium trichloroisocyanurate according to claim 1, characterized in that: The mass ratio of oxamyl to sodium trichloroisocyanurate is 1:1 to 4:1 or 60:1 to 200:

1.

3. The bactericidal composition of oxamyl and sodium trichloroisocyanurate according to claim 2, characterized in that: The mass ratio of oxamyl to sodium trichloroisocyanurate is 80:1 to 200:

1.

4. The bactericidal composition of oxamyl and sodium trichloroisocyanurate according to claim 1, characterized in that: The bactericidal composition further includes 1,3-propanesulfonate lactone; the total amount of oxamyl and sodium trichloroisocyanurate and the mass ratio of 1,3-propanesulfonate lactone are 30:1 to 90:

1.

5. The bactericidal composition of oxamyl and sodium trichloroisocyanurate according to claim 1 or 4, characterized in that: The total content of the oxamyl and sodium trichloroisocyanurate is 25% to 80% by mass percentage, and the content of 1,3-propanesulfonate lactone is 0.2% to 1%.

6. The bactericidal composition of oxamyl and sodium trichloroisocyanurate according to any one of claims 1-5, characterized in that: The active ingredients are hymexazol and sodium trichloroisocyanurate, with 1,3-propanesulfonate lactone as a synergist, and are compounded with adjuvants and one of the fillers or solvents to form an aqueous suspension or wettable powder.

7. The application of the bactericidal composition of oxamyl and sodium trichloroisocyanurate as described in any one of claims 1-4 in the prevention and control of downy mildew, wilt, damping-off, and black spot in plants.

8. The application of the bactericidal composition of oxamyl and sodium trichloroisocyanurate as described in any one of claims 1-4 in the prevention and control of downy mildew of watermelon and black spot of wheat.

9. A wettable powder, characterized in that: It is made from the following components in the following mass percentages: 25% to 80% of the total amount of oxamyl and sodium trichloroisocyanurate, 2% to 8% of wetting agent, 2% to 10% of dispersant, 0.2% to 1% of 1,3-propanesulfonate lactone, and the remainder being filler; and the mass ratio of oxamyl to sodium trichloroisocyanurate meets the requirements of any one of claims 1-3, and the mass ratio of the total amount of oxamyl to sodium trichloroisocyanurate and the mass ratio of 1,3-propanesulfonate lactone meets the requirements of claim 4; The wetting agent is selected from at least one of sodium dodecyl sulfate, sodium dodecylbenzene sulfonate, butyl naphthalene sulfonate, and alkyl naphthalene sulfonate; the dispersant is selected from at least one of lignin sulfonate, naphthalene sulfonate, and polycarboxylate; and the filler is selected from at least one of light calcium carbonate, calcined kaolin, corn starch, and maltodextrin.

10. An aqueous suspension agent, characterized in that: It is made from the following components in the following mass percentages: 25%–80% of the total amount of oxamyl and sodium trichloroisocyanurate, 2%–8% of wetting agent, 2%–10% of dispersant, 0.10%–0.65% of thickener, 4%–6% of antifreeze, 0%–5% of binder, 0%–5% of disintegrant, 0.3%–1% of defoamer, 0.2%–1% of 1,3-propanesulfonate lactone, and the remainder being water; and the mass ratio of oxamyl to sodium trichloroisocyanurate meets the requirements of any one of claims 1-3, and the mass ratio of the total amount of oxamyl to sodium trichloroisocyanurate and the mass ratio of 1,3-propanesulfonate lactone meets the requirements of claim 4; The wetting agent is selected from at least one of sodium dodecyl sulfate, sodium dodecylbenzene sulfonate, butyl naphthalene sulfonate, and alkyl naphthalene sulfonate; the dispersant is selected from at least one of lignin sulfonate, naphthalene sulfonate, carboxylate, and polycarboxylate; the thickener is selected from a combination of xanthan gum and magnesium aluminum silicate in a mass ratio of 1:2 to 1:2.5; the antifreeze is selected from one of ethylene glycol, propylene glycol, and glycerol; the binder is selected from at least one of maltodextrin and starch; the disintegrant is selected from at least one of silicon-low substituted hydroxypropyl cellulose, sodium carboxymethyl starch, urea, and ammonium sulfate; and the defoamer is selected from at least one of polyethylene glycol fatty acid, tributyl phosphate, and organosilicon defoamers.

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