Novel immunofluorescence chromatography analytical instrument
By introducing sliding and vibrating structures, auxiliary cleaning devices, and quantitative separation devices into the immunofluorescence chromatography analyzer, the problems of cumbersome pretreatment and incomplete cleaning are solved, achieving easy and convenient pretreatment and accurate detection results.
Patent Information
- Application Number
- CN202511896798.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-12-16
- Publication Date
- 2026-03-03
AI Technical Summary
The pretreatment steps of existing immunofluorescence chromatography analyzers are cumbersome, requiring manual shaking of reagent tubes, which can cause arm pain and pose health risks. Furthermore, incomplete dilution of the cleaning solution may lead to incorrect test results.
The reagent tube is automatically shaken using a sliding and vibrating structure, combined with an auxiliary cleaning device and a quantitative separation device, to ensure complete dilution and quantitative addition of the cleaning solution and prevent liquid spillage.
This makes the pretreatment process of immunofluorescence chromatography analyzers easier and more convenient, avoiding arm pain and incorrect test results, and ensuring the cleaning effect and the accuracy of liquid management.
Smart Images
Figure CN121595853A_ABST
Abstract
Description
Technical Field
[0001] This application relates to the technical field of detection equipment, and in particular to a novel immunofluorescence chromatography analyzer. Background Technology
[0002] Immunofluorescence chromatography analyzers are important tools for biomedical research and clinical diagnosis. These instruments combine the advantages of immunofluorescence technology and chromatography, enabling highly sensitive and specific detection of specific antigens or antibodies in biological samples. Current techniques require pretreatment of the biological sample before detection. This involves extracting the sample, placing it in a reagent tube, adding a solution, and shaking the tube to accelerate sample dissolution. Then, a washing solution is added while the tube is shaken to dilute and rinse magnetic particles. Finally, the reagent tube is placed in the immunofluorescence chromatography analyzer's inlet, and the analyzer can be operated.
[0003] The pretreatment steps in the existing technology are not only cumbersome, but also require manual shaking of the reagent tubes, which can easily cause arm pain for testing personnel after long hours of work, and may pose a significant health risk. Therefore, this application proposes a novel immunofluorescence chromatography analyzer to make it easier and more convenient for testing personnel to preprocess biological samples. Summary of the Invention
[0004] To address the shortcomings of existing technologies, the purpose of this application is to provide a novel immunofluorescence chromatography analyzer that makes it easier and more convenient for testing personnel to preprocess biological samples.
[0005] The above-mentioned objective of this application is achieved through the following technical solution: a novel immunofluorescence chromatography analyzer, comprising an analyzer body and a pretreatment device disposed on the outside of the analyzer body. The pretreatment device includes a pretreatment box, a sliding structure disposed within the pretreatment box, a mounting housing disposed on the sliding structure, and vibration structures disposed on both sides of the sliding structure for driving the mounting housing to vibrate. The sliding structure includes a sliding platform and a groove opened along the length direction of the sliding platform. The mounting housing is slidably connected to the sliding platform through the groove.
[0006] Furthermore, the vibration structure includes a vibration spring disposed on one side of the mounting housing, a vibration motor disposed on the other side of the mounting housing, and a vibration cam disposed on the output end of the vibration motor. One end of the vibration spring is fixedly connected to the inner wall of the pretreatment box, and the other end abuts against the mounting housing. The circumferential surface of the vibration cam faces the mounting housing, and the vibration cam is located above the slide groove.
[0007] By adopting the above technical solution, before testing, the personnel place the biological sample in a reagent tube, add solution to the reagent tube, place the reagent tube in the mounting housing, and then start the vibration motor. The output of the vibration motor drives the vibration cam to rotate, causing the vibration cam to intermittently push the mounting housing towards the vibration spring, thus compressing the vibration spring. When the vibration cam is not in contact with the mounting housing, the compressed vibration spring pushes the mounting housing towards the vibration cam. This process repeats, causing the reagent tube inside the mounting housing to shake, accelerating the dissolution of the biological sample. After a period of time, cleaning solution is added to the reagent tube, and the vibration motor is started again, causing the cleaning solution to dilute and rinse the magnetic particles. The reagent tube is then placed in the placement port of the analyzer body, and the analyzer body is started. In this way, the personnel can complete the pretreatment of biological samples without shaking the reagent tube, making the pretreatment of biological samples easier and more convenient for the personnel.
[0008] Furthermore, an auxiliary cleaning device is provided inside the pretreatment box on the side away from the vibration spring to enable the cleaning fluid to clean the magnetic particles more thoroughly.
[0009] Furthermore, the auxiliary cleaning device includes an auxiliary electric cylinder installed inside the pretreatment box on the side away from the vibration spring, and an arc-shaped magnet fixedly installed on the output end of the auxiliary electric cylinder. The output end of the auxiliary electric cylinder faces the mounting housing. An auxiliary notch is provided on the upper end of the mounting housing near the auxiliary electric cylinder. A placement ring is provided on the outside of the pretreatment box, and a solution extraction syringe is placed on the placement ring.
[0010] While the sliding and vibrating structures make pretreatment of biological samples easier and more convenient for testing personnel, the vibration structure only allows the reagent tube to sway left and right. This means that when the cleaning solution is added to the reagent tube, it can only dilute and rinse the magnetic particles in the lower half of the biological sample, preventing the cleaning solution from completely diluting and rinsing the magnetic particles. This can lead to erroneous test results. The auxiliary cleaning device solves this problem. Before adding cleaning solution to the reagent tube, the auxiliary electric cylinder extends its output end, allowing the arc-shaped magnet to extend through the auxiliary notch into the housing and adhere to the outer wall of the reagent tube, attracting the magnetic particles. The operator then uses a solution extraction syringe to extract the solution. At this point, the auxiliary electric cylinder retracts, causing the arc-shaped magnet to no longer adhere to the outer wall of the reagent tube, allowing the magnetic particles to fall to the bottom. Cleaning solution is then added to the reagent tube to fully dilute and rinse the magnetic particles. After adding the solution again, the vibration structure is activated to vibrate the reagent tube, completely diluting and rinsing the magnetic particles and preventing erroneous test results.
[0011] Furthermore, the pretreatment box is provided with an installation ring on the outside, on which a cleaning fluid extraction syringe is placed, and the pretreatment box is provided with a quantitative separation device for quantitatively separating the cleaning fluid.
[0012] Furthermore, the quantitative separation device includes a separation housing and a quantitative housing installed inside the separation housing, wherein the top surface of the quantitative housing and the top surface of the separation housing are coplanar.
[0013] While the auxiliary cleaning device can prevent potential errors in test results, it also makes it difficult for operators to control the amount of cleaning solution added to the reagent tube. This can lead to overflow when the solution is added to the reagent tube later. The quantitative separation device solves this problem. Before adding cleaning solution to the reagent tube, cleaning solution is first added to the quantitative housing, causing it to overflow into the separation housing. At this point, the volume of cleaning solution in the quantitative housing is fixed. Operators only need to use a cleaning solution extraction syringe to extract the cleaning solution from the quantitative housing, and then add the cleaning solution from the extraction syringe to the reagent tube. This ensures that the volume of cleaning solution added to the reagent tube is fixed, preventing overflow due to operator error.
[0014] Furthermore, the interior and bottom surface of the partition housing are provided with drainage structures for discharging the cleaning fluid inside the partition housing.
[0015] Furthermore, the drainage structure includes a plurality of drainage holes formed inside and penetrating the partition shell, and a receiving box placed directly below the partition shell, with the opening of the receiving box facing upward.
[0016] By adopting the above technical solution, although the setting of the quantitative separation device can prevent the tester from having difficulty controlling the amount of cleaning solution when adding cleaning solution to the reagent tube, resulting in the solution overflowing the reagent tube, the cleaning solution continuously accumulating in the separation shell will affect the quantitative effect of the quantitative shell. The setting of the drainage structure solves this technical problem. Through the setting of the drainage structure, the cleaning solution overflowing from the quantitative shell flows into the receiving box through the drainage hole, preventing the cleaning solution from accumulating in the separation shell and affecting the quantitative effect of the quantitative shell. The cleaning solution in the receiving box can simply be poured out.
[0017] Furthermore, the upper outer side of the pretreatment box is provided with a protective structure to prevent liquid from spilling out of the reagent tube.
[0018] Furthermore, the protective structure includes an interface on the upper side of the pretreatment box and a protective plate inserted into the pretreatment box through the interface.
[0019] By adopting the above technical solution and setting up a protective structure, before the testing personnel start the vibration structure, they can push the protective plate to block the top of the reagent tube (the height of the reagent tube is fixed, and the production personnel only need to open the insertion interface according to the height of the reagent tube placed in the installation housing so that the protective plate can completely block the top of the reagent tube), preventing the liquid inside the reagent tube from spilling out when the vibration structure vibrates the reagent tube.
[0020] In summary, this application includes at least one of the following beneficial technical effects:
[0021] 1. By using a sliding and vibrating structure, the biological sample is first placed in the reagent tube, then a solution is added to the tube. The reagent tube is then placed in the mounting housing, and the vibration motor is activated. The output of the vibration motor drives the vibration cam to rotate, causing the vibration cam to intermittently push the mounting housing towards the vibration spring. This compresses the vibration spring, which, when the vibration cam is not in contact with the mounting housing, pushes the mounting housing towards the vibration cam. This cycle repeats, causing the reagent tube inside the mounting housing to vibrate, accelerating the dissolution of the biological sample. After a period of time, cleaning solution is added to the reagent tube, and the vibration motor is activated again to dilute and rinse the magnetic particles. The reagent tube is then placed in the placement port of the analyzer body, and the analyzer body is activated. This allows the testing personnel to complete the pretreatment of biological samples without shaking the reagent tube, making the pretreatment of biological samples easier and more convenient. Attached Figure Description
[0022] Figure 1 This is a schematic diagram of the overall structure of the embodiment;
[0023] Figure 2 It is along Figure 1 Sectional view of line AA in the middle;
[0024] Figure 3 This is a top view of the overall structure of the embodiment;
[0025] Figure 4 yes Figure 3 Enlarged view of section A.
[0026] Reference numerals: 1. Analyzer body; 2. Pretreatment box; 20. Mounting housing; 21. Auxiliary notch; 22. Placement ring; 23. Solution extraction syringe; 24. Mounting ring; 25. Cleaning solution extraction syringe; 3. Sliding structure; 30. Sliding platform; 31. Slide groove; 4. Vibration structure; 40. Vibration spring; 41. Vibration motor; 42. Vibration cam; 5. Auxiliary cleaning device; 50. Auxiliary electric cylinder; 51. Arc magnet; 6. Quantitative separation device; 60. Separation housing; 61. Quantitative housing; 7. Drainage structure; 70. Drainage hole; 71. Receiving box; 8. Protective structure; 80. Insertion interface; 81. Protective plate. Detailed Implementation
[0027] The present application will be further described in detail below with reference to the accompanying drawings.
[0028] Example, refer to Figure 1 , Figure 2A novel immunofluorescence chromatography analyzer includes an analyzer body 1 and a pretreatment device disposed outside the analyzer body 1. The pretreatment device includes a pretreatment chamber 2, a sliding structure 3 disposed within the pretreatment chamber 2, a mounting housing 20 disposed on the sliding structure 3, and vibration structures 4 disposed on both sides of the sliding structure 3 for vibrating the mounting housing 20. The sliding structure 3 includes a sliding platform 30 and a groove 31 formed along the length of the sliding platform 30. The mounting housing 20 is slidably connected to the sliding platform 30 through the groove 31. The vibration structure 4 includes a vibration spring 40 disposed on one side of the mounting housing 20, a vibration motor 41 disposed on the other side of the mounting housing 20, and a vibration cam 42 disposed on the output end of the vibration motor 41. One end of the vibration spring 40 is fixedly connected to the inner wall of the pretreatment chamber 2, and the other end abuts against the mounting housing 20. The circumferential surface of the vibration cam 42 faces the mounting housing 20 and is located above the groove 31. Before the test is performed, the biological sample is placed in a reagent tube. Inside the reagent tube, solution is added, and the reagent tube is placed inside the mounting housing 20. Then, the vibration motor 41 is started, and the output of the vibration motor 41 drives the vibration cam 42 to rotate, causing the vibration cam 42 to intermittently push the mounting housing 20 towards the vibration spring 40, thus compressing the vibration spring 40. When the vibration cam 42 is not in contact with the mounting housing 20, the compressed vibration spring 40 pushes the mounting housing 20 towards the vibration cam 42. This process is repeated, causing the reagent tube inside the mounting housing 20 to shake, accelerating the dissolution of the biological sample. After a period of time, cleaning solution is added to the reagent tube, and the vibration motor 41 is started again, causing the cleaning solution to dilute and rinse the magnetic particles. Then, the reagent tube is placed at the placement port of the analyzer body 1, and the analyzer body 1 is started. In this way, the testing personnel do not need to shake the reagent tube to complete the pretreatment of the biological sample, achieving the goal of making the pretreatment of biological samples easier and more convenient for the testing personnel.
[0029] Although the sliding structure 3 and the vibration structure 4 make it easier and more convenient for testing personnel to preprocess biological samples, the vibration structure 4 can only make the reagent tube shake left and right. This means that when the cleaning solution is added to the reagent tube, it can only dilute and rinse the magnetic particles of the biological sample in the lower half of the reagent tube. This means that the cleaning solution cannot completely dilute and rinse the magnetic particles, which may lead to errors in the test results. To solve this technical problem, an auxiliary cleaning device 5 is provided inside the pretreatment box 2 on the side away from the vibration spring 40 to make the cleaning solution clean the magnetic particles more thoroughly. The auxiliary cleaning device 5 includes an auxiliary electric cylinder 50 installed inside the pretreatment box 2 on the side away from the vibration spring 40 and an arc-shaped magnet 51 fixedly installed on the output end of the auxiliary electric cylinder 50. The output end of the auxiliary electric cylinder 50 faces the mounting housing 20, and the upper end of the mounting housing 20 is close to the auxiliary electric cylinder 50. An auxiliary notch 21 is provided, and a placement ring 22 is provided on the outside of the pretreatment box 2. A solution extraction syringe 23 is placed on the placement ring 22. With the setting of the auxiliary cleaning device 5, before the tester adds cleaning solution to the reagent tube, the output end of the auxiliary electric cylinder 50 is extended, so that the arc magnet 51 extends into the mounting housing 20 through the auxiliary notch 21 and attaches to the outer wall of the reagent tube, adsorbing the magnetic particles. Then the tester uses the solution extraction syringe 23 to extract the solution. At this time, the output end of the auxiliary electric cylinder 50 is retracted, so that the arc magnet 51 no longer attaches to the outer wall of the reagent tube, and the magnetic particles fall to the bottom of the reagent tube. Then the cleaning solution is added to the reagent tube to completely dilute and rinse the magnetic particles. Then the solution is added to the reagent tube, and the vibration structure 4 is activated to vibrate the reagent tube to completely dilute and rinse the magnetic particles, preventing possible errors in the test results.
[0030] Although the auxiliary cleaning device 5 can prevent errors in the test results, it also makes it difficult for the tester to control the amount of cleaning solution added to the reagent tube. This can lead to overflow of the solution when it is added to the reagent tube later. To solve this problem, this embodiment has a mounting ring 24 on the outside of the pretreatment box 2, on which a cleaning solution extraction syringe 25 is placed. A quantitative separation device 6 for quantitatively separating the cleaning solution is provided on the outside of the pretreatment box 2. The quantitative separation device 6 includes a separation shell 60 and a quantitative shell 61 installed inside the separation shell 60. The top surface of the quantitative shell 61 and the top surface of the separation shell 60 are connected. With the quantitative separation device 6, before adding cleaning solution to the reagent tube, cleaning solution is first added to the quantitative housing 61, causing the cleaning solution to overflow from the quantitative housing 61 into the separation housing 60. At this time, the cleaning solution in the quantitative housing 61 has a fixed volume. The testing personnel only need to use the cleaning solution extraction syringe 25 to extract the cleaning solution in the quantitative housing 61, and then add the cleaning solution in the cleaning solution extraction syringe 25 into the reagent tube. In this way, the volume of cleaning solution added to the reagent tube by the testing personnel is fixed, preventing the testing personnel from having difficulty controlling the amount of cleaning solution when adding cleaning solution to the reagent tube, which could lead to the solution overflowing into the reagent tube.
[0031] Although the quantitative separator 6 can prevent the amount of cleaning solution added to the reagent tube from being difficult to control and causing the solution to overflow, the continuous accumulation of cleaning solution in the separator 60 will affect the quantitative effect of the quantitative housing 61. To solve this technical problem, refer to... Figure 3 , Figure 4 In this embodiment, a drainage structure 7 is provided inside the partition shell 60 and on its bottom surface to discharge the cleaning liquid inside the partition shell 60. The drainage structure 7 includes multiple drainage holes 70 that are opened inside the partition shell 60 and penetrate the partition shell 60, and a receiving box 71 placed directly below the partition shell 60. The opening of the receiving box 71 faces upward. Through the arrangement of the drainage structure 7, the cleaning liquid overflowing from the metering shell 61 flows into the receiving box 71 through the drainage holes 70, preventing the cleaning liquid from accumulating inside the partition shell 60 and affecting the metering effect of the metering shell 61. The cleaning liquid in the receiving box 71 can simply be poured out.
[0032] In this embodiment, a protective structure 8 is provided on the upper outer side of the pretreatment box 2 to prevent liquid inside the reagent tube from spilling out. The protective structure 8 includes an interface 80 opened on the upper outer side of the pretreatment box 2 and a protective plate 81 inserted into the pretreatment box 2 through the interface 80. With the setting of the protective structure 8, before the testing personnel start the vibration structure 4, they can push the protective plate 81 to block the top of the reagent tube (the height of the reagent tube is fixed, and the production personnel only need to open the interface 80 according to the height of the reagent tube placed in the mounting housing 20 so that the protective plate 81 can completely block the top of the reagent tube), preventing the liquid inside the reagent tube from spilling out when the vibration structure 4 vibrates the reagent tube.
[0033] Specific implementation process: The biological sample is placed in the reagent tube, then a solution is added. The reagent tube is then placed inside the mounting housing 20. The protective plate 81 is pushed to block the top of the reagent tube. The vibration motor 41 is then activated, and its output drives the vibration cam 42 to rotate. This causes the vibration cam 42 to intermittently push the mounting housing 20 towards the vibration spring 40, compressing the vibration spring 40. When the vibration cam 42 is not in contact with the mounting housing 20, the compressed vibration spring 40 pushes the mounting housing 20 towards the vibration cam 42. This process repeats, causing the reagent tube inside the mounting housing 20 to shake. After a period of time, the protective plate 81 is pulled to expose the top of the reagent tube. Then, the output of the auxiliary electric cylinder 50 is extended, allowing the arc-shaped magnet 51 to extend into the mounting housing 20 through the auxiliary notch 21. The magnetic particles are adsorbed onto the outer wall of the reagent tube. Then, the tester uses the solution extraction syringe 23 to extract the solution. At this time, the output end of the auxiliary electric cylinder 50 is activated to retract, so that the arc magnet 51 is no longer attached to the outer wall of the reagent tube, causing the magnetic particles to fall to the bottom of the reagent tube. Then, cleaning solution is added into the quantitative housing 61, causing the cleaning solution to overflow from the quantitative housing 61 and flow into the separator housing 60. At this time, the cleaning solution in the quantitative housing 61 is a fixed volume. Then, the cleaning solution is extracted from the quantitative housing 61 using the cleaning solution extraction syringe 25 and added to the reagent tube. Then, the solution is added to the reagent tube, and the protective plate 81 is pushed to block the top of the reagent tube. Then, the vibration motor 41 is activated, so that the cleaning solution further dilutes and rinses the magnetic particles. Then, the reagent tube is placed at the placement port of the analyzer body 1, and the analyzer body 1 is activated to complete the detection.
[0034] The embodiments described in this specific implementation are preferred embodiments of this application and are not intended to limit the scope of protection of this application. Therefore, all equivalent changes made in accordance with the structure, shape and principle of this application should be covered within the scope of protection of this application.
Claims
1. A novel immunofluorescence chromatography analyzer, characterized in that, The analyzer includes an analyzer body (1) and a pretreatment device disposed on the outside of the analyzer body (1). The pretreatment device includes a pretreatment box (2), a sliding structure (3) disposed in the pretreatment box (2), a mounting housing (20) disposed on the sliding structure (3), and a vibration structure (4) disposed on both sides of the sliding structure (3) for pushing the mounting housing (20) to vibrate. The sliding structure (3) includes a sliding platform (30) and a groove (31) opened along the length of the sliding platform (30). The mounting housing (20) is slidably connected to the sliding platform (30) through the groove (31).
2. The novel immunofluorescence chromatography analyzer according to claim 1, characterized in that, The vibration structure (4) includes a vibration spring (40) disposed on one side of the mounting housing (20), a vibration motor (41) disposed on the other side of the mounting housing (20), and a vibration cam (42) disposed on the output end of the vibration motor (41). One end of the vibration spring (40) is fixedly connected to the inner wall of the pretreatment box (2), and the other end abuts against the mounting housing (20). The circumferential surface of the vibration cam (42) faces the mounting housing (20), and the vibration cam (42) is located above the slide groove (31).
3. The novel immunofluorescence chromatography analyzer according to claim 2, characterized in that, The pretreatment box (2) is equipped with an auxiliary cleaning device (5) on the side away from the vibration spring (40) to make the cleaning fluid clean the magnetic particles more thoroughly.
4. The novel immunofluorescence chromatography analyzer according to claim 3, characterized in that, The auxiliary cleaning device (5) includes an auxiliary electric cylinder (50) installed inside the pretreatment box (2) on the side away from the vibration spring (40) and an arc-shaped magnet (51) fixedly installed on the output end of the auxiliary electric cylinder (50). The output end of the auxiliary electric cylinder (50) faces the mounting housing (20). An auxiliary notch (21) is provided on the upper end of the mounting housing (20) near the auxiliary electric cylinder (50). A placement ring (22) is provided on the outside of the pretreatment box (2), and a solution extraction syringe (23) is placed on the placement ring (22).
5. The novel immunofluorescence chromatography analyzer according to claim 1, characterized in that, The pretreatment box (2) is provided with an installation ring (24) on the outside, and a cleaning fluid extraction syringe (25) is placed on the installation ring (24). The pretreatment box (2) is provided with a quantitative separation device (6) for quantitatively separating the cleaning fluid.
6. The novel immunofluorescence chromatography analyzer according to claim 5, characterized in that, The quantitative separation device (6) includes a separation shell (60) and a quantitative shell (61) installed inside the separation shell (60), wherein the top surface of the quantitative shell (61) and the top surface of the separation shell (60) are coplanar.
7. The novel immunofluorescence chromatography analyzer according to claim 6, characterized in that, The partition housing (60) is provided with a drainage structure (7) for discharging the cleaning fluid inside the partition housing (60) and on its bottom surface.
8. The novel immunofluorescence chromatography analyzer according to claim 7, characterized in that, The drainage structure (7) includes a plurality of drainage holes (70) opened inside the partition shell (60) and penetrating the partition shell (60) and a receiving box (71) placed directly below the partition shell (60), the receiving box (71) having an upward opening.
9. The novel immunofluorescence chromatography analyzer according to claim 1, characterized in that, The upper outer side of the pretreatment box (2) is provided with a protective structure (8) to prevent the liquid inside the reagent tube from spilling out.
10. The novel immunofluorescence chromatography analyzer according to claim 9, characterized in that, The protective structure (8) includes an interface (80) located on the upper side of the pretreatment box (2) and a protective plate (81) inserted into the pretreatment box (2) through the interface (80).