Evaluation method of PRP (platelet rich plasma) administration concentration for joint movement injury repair
By assessing changes in C-reactive protein levels, joint swelling, and cortisol levels, the PRP dosage was dynamically adjusted, solving the problem of inaccurate PRP administration and improving the effectiveness of joint movement injury repair.
Patent Information
- Application Number
- CN202511793956.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-12-02
- Publication Date
- 2026-03-03
AI Technical Summary
In existing technologies, the concentration of PRP administration is not dynamically adjusted according to the needs of different repair stages during joint movement injury repair, resulting in inaccurate administration and potentially affecting the repair effect.
By analyzing changes in C-reactive protein levels, joint swelling, and cortisol levels before the most recent PRP administration, the inflammation and repair status can be assessed, and the concentration of the next PRP administration can be adjusted to match the specific repair needs of joint movement injuries.
It improves the accuracy and reliability of PRP dosage and enhances the overall effect of joint injury repair.
Smart Images
Figure CN121601140A_ABST
Abstract
Description
Technical Field
[0001] This invention relates to the field of specific therapeutic activity technology of pharmaceutical preparations, and specifically to a method for evaluating the concentration of PRP administered for the repair of joint movement injuries. Background Technology
[0002] The core goal of joint sports injury repair is to restore the joint to its normal mobility and stability. PRP (Platelet-Rich Plasma) is platelet-rich plasma separated from autologous blood through methods such as centrifugation. Once activated, platelets can release a variety of growth factors, such as platelet-derived growth factor, transforming growth factor-β, and vascular endothelial growth factor. These growth factors can promote cell proliferation, differentiation, and extracellular matrix synthesis, thereby promoting the repair of joint cartilage, ligaments, and other tissues.
[0003] In the repair of joint motion injuries using PRP, a fixed concentration of PRP is administered each time. This approach fails to consider that joint motion injury repair is a dynamic process, and the required PRP concentration may differ at different stages of repair. For example, in the early stages of injury, a higher concentration of PRP may be needed to initiate the inflammatory response and promote cell proliferation; while in the later stages of repair, excessively high PRP concentrations may have negative effects, such as excessive inflammation or impaired tissue remodeling, leading to inaccurate PRP administration. Summary of the Invention
[0004] To address the technical problem of inaccurate PRP administration, the present invention aims to provide a method for evaluating PRP concentration for joint injury repair. The specific technical solution adopted is as follows: This invention provides a method for evaluating the concentration of PRP (particulate rehydration solution) for the repair of joint sports injuries, comprising: Based on the changes in C-reactive protein levels multiple times prior to the most recent PRP administration, the overall inflammatory repair profile was obtained. Based on the changes in the degree of joint swelling within each detection segment, the joint swelling repair characteristics of each detection segment are obtained; the detection segment is the time period between two adjacent C-reactive protein levels. The correlation between joint swelling repair characteristics and changes in C-reactive protein levels was determined, and the comprehensive repair effect characteristics were obtained by combining the joint swelling repair characteristics with the comprehensive inflammation repair manifestations. Based on the abnormal cortisol hormone levels observed multiple times prior to the most recent PRP administration, the hormone level deviation characteristics were obtained. The concentration of PRP for the next administration will be adjusted based on the overall repair effect characteristics and the deviation characteristics of hormone levels.
[0005] In an exemplary embodiment, the process of obtaining the comprehensive inflammatory repair performance includes: The difference between the first and last C-reactive protein levels in the multiple C-reactive protein levels is determined, and the comprehensive inflammation repair performance is obtained based on the difference; the comprehensive inflammation repair performance is positively correlated with the difference.
[0006] In an exemplary embodiment, the process of obtaining the joint swelling repair features includes: The joint swelling degree sequence is used to determine the worsening manifestation of joint swelling, wherein the joint swelling degree sequence is obtained by arranging the joint swelling degree within the detection segment in chronological order; Determine whether there is a period of continuously worsening swelling in the sequence of joint swelling degrees, wherein the period of continuously worsening swelling indicates that the degree of joint swelling continues to increase; If there is a period of continuous worsening of swelling in the joint swelling degree sequence, then the joint swelling repair characteristics are obtained based on the duration of the period of continuous worsening of swelling and the manifestation of joint swelling worsening; the joint swelling repair characteristics are inversely correlated with the duration of the period of continuous worsening of swelling and the manifestation of joint swelling worsening. If there is no period of continuous worsening of swelling in the joint swelling degree sequence, then a period of continuous relief of swelling in the joint swelling degree sequence is determined. Based on the duration of the period of continuous relief of swelling and the manifestation of worsening joint swelling, the joint swelling repair characteristics are obtained. The joint swelling repair characteristics are positively correlated with the duration of the period of continuous relief of swelling and negatively correlated with the manifestation of worsening joint swelling.
[0007] In one exemplary embodiment, the process of obtaining the aggravated joint swelling includes: Determine the first-order difference sequence of the joint swelling degree sequence, and calculate the average value of the positive numbers in the first-order difference sequence; The worsening of joint swelling is obtained based on the average value of the positive numbers in the first-order difference sequence.
[0008] In an exemplary embodiment, the process of obtaining the period during which the swelling continues to worsen includes: The corresponding positions of consecutively occurring positive numbers in the first-order difference sequence in the joint swelling degree sequence are determined as the period of continuous worsening of swelling; The process of obtaining the period of sustained swelling relief includes: The corresponding positions of consecutively occurring negative numbers in the first-order difference sequence in the joint swelling degree sequence are determined as the period of sustained swelling relief.
[0009] In an exemplary embodiment, the process of obtaining the comprehensive repair effect characteristics includes: By integrating the joint swelling repair characteristics of each detection segment, a comprehensive feature of joint swelling repair is obtained; The comprehensive repair effect characteristics are obtained based on the correlation of changes, the comprehensive characteristics of joint swelling repair, and the comprehensive inflammation repair performance; the comprehensive repair effect characteristics are all positively correlated with the correlation of changes, the comprehensive characteristics of joint swelling repair, and the comprehensive inflammation repair performance.
[0010] In one exemplary embodiment, the process of obtaining the hormone level deviation characteristic includes: Determine the severity of the repeated cortisol hormone levels; The overall deviation of cortisol levels is determined based on the relationship between the maximum, minimum, and last cortisol levels in the multiple cortisol level readings and the preset normal range for cortisol levels. The deviation characteristics of the hormone levels are obtained by combining the severity and the degree of deviation of the cortisol hormone levels.
[0011] In one exemplary embodiment, the process of obtaining the overall deviation of the cortisol hormone level includes: The degree of deviation of a candidate cortisol level is determined by the relationship between the candidate cortisol level and the preset normal range of cortisol levels. Specifically, if the candidate cortisol level is greater than the upper limit of the preset normal range, the difference between the candidate cortisol level and the upper limit is calculated to obtain the degree of deviation. If the candidate cortisol level is within the preset normal range, the degree of deviation is 0. If the candidate cortisol level is less than the lower limit of the preset normal range, the difference between the lower limit and the candidate cortisol level is calculated to obtain the degree of deviation. The candidate cortisol level can be any one of the maximum, minimum, and last cortisol levels. The overall deviation of the cortisol level is obtained by combining the deviations of the maximum, minimum, and last cortisol levels.
[0012] In an exemplary embodiment, adjusting the concentration of the next PRP administration based on the comprehensive repair effect characteristics and hormone level deviation characteristics includes: Based on the comprehensive repair effect characteristics and hormone level deviation characteristics, the repair homeostasis characteristics are obtained; the repair homeostasis characteristics are positively correlated with the comprehensive repair effect characteristics and negatively correlated with the hormone level deviation characteristics. The concentration of the next PRP administration will be determined based on the repair homeostasis characteristics.
[0013] In one exemplary embodiment, determining the next PRP dosing concentration based on repair homeostasis characteristics includes: The adjustment range of the PRP administration concentration is obtained based on the difference between the repair steady-state characteristics and the preset repair steady-state characteristic threshold, and the most recent PRP administration concentration. The repair steady-state characteristic is compared with a preset repair steady-state characteristic threshold. If the repair steady-state characteristic is greater than or equal to the preset repair steady-state characteristic threshold, the difference between the most recent PRP administration concentration and the adjustment range is determined as the next PRP administration concentration. If the repair steady-state characteristic is less than the preset repair steady-state characteristic threshold, the sum of the most recent PRP administration concentration and the adjustment range is determined as the next PRP administration concentration.
[0014] The present invention has the following beneficial effects: The present invention performs a comprehensive analysis of multi-dimensional physiological data on changes in C-reactive protein levels, changes in joint swelling, and abnormalities in cortisol levels before the most recent PRP administration, and obtains the PRP administration concentration related to the current joint movement injury repair status, effectively improving the accuracy and reliability of PRP administration concentration determination, thereby improving the overall effect of joint injury repair. Attached Figure Description
[0015] Figure 1 This is a flowchart of a method for evaluating the concentration of PRP for joint motion injury repair provided in one embodiment of the present invention; Figure 2 This is a flowchart illustrating the acquisition of joint swelling repair features according to an embodiment of the present invention; Figure 3 This is a flowchart of the process for obtaining hormone level deviation characteristics provided in one embodiment of the present invention. Detailed Implementation
[0016] To further illustrate the technical means and effects adopted by the present invention to achieve its intended purpose, the specific implementation methods, structures, features, and effects of the present invention are described in detail below with reference to the accompanying drawings and preferred embodiments. In the following description, different "one embodiment" or "another embodiment" do not necessarily refer to the same embodiment. Furthermore, specific features, structures, or characteristics in one or more embodiments can be combined in any suitable form.
[0017] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. All data and information collected in this application have been obtained with full consent.
[0018] This embodiment provides a method for assessing PRP (particulate rehydration solution) concentration for joint injury repair. During joint injury repair, the method uses relevant physiological data prior to the most recent PRP administration to determine the concentration for the next administration. This embodiment requires collecting the PRP concentration for each injection and relevant physiological data during the joint injury repair process.
[0019] This embodiment requires collecting relevant physiological data, including C-reactive protein levels, joint swelling, and cortisol levels, prior to the most recent PRP administration during the joint injury repair process. The most recent PRP administration refers to the administration of PRP relative to the current time. The ultimate goal of this embodiment is to determine the concentration of the next PRP administration following the most recent administration, i.e., the concentration to be administered in the next PRP dose.
[0020] C-reactive protein (CRP) level, as an inflammatory marker, is an acute-phase reactive protein. CRP levels rise rapidly during inflammation and gradually decrease as inflammation subsides, indicating that inflammation is under control and conducive to damage repair. CRP levels are characterized by their concentration in the blood, typically measured in milligrams per liter (mg / L). This is obtained through blood sampling. Multiple CRP level tests are performed before the most recent PRP administration. The sampling frequency, i.e., the time interval between two consecutive CRP level tests, is set according to the actual situation, such as weekly testing. This embodiment normalizes CRP levels to a value range of 0-1 to eliminate dimensions and facilitate subsequent data processing. In an exemplary embodiment, this embodiment may employ a maximum and minimum value normalization method. The maximum and minimum values involved in this method are set according to actual conditions. For example, the maximum value is the theoretical maximum C-reactive protein (CRP) level, and the minimum value is the theoretical minimum CRP level. The theoretical maximum CRP level represents the CRP level in a person with severe inflammation. When the level exceeds this theoretical maximum, it indicates that the person may already have serious problems such as septic shock or multiple organ dysfunction, significantly increasing the risk of death. In this case, immediate treatment is required, and the data processing procedure of this embodiment is not executed. The theoretical minimum CRP level is the CRP level in a person without inflammation, typically a very small positive value, or even 0. All CRP levels mentioned below are normalized and dimensionless data.
[0021] The degree of joint swelling can be characterized by the circumference of the swollen area. At each data collection, the circumference of the swollen area is measured using a soft measuring tape, for example, the circumference of the swollen area in the knee joint. This circumference is used as the degree of joint swelling. Multiple data collections of joint swelling are performed before the most recent PRP administration. The sampling frequency for joint swelling is higher than that for C-reactive protein levels; as a specific example, joint swelling can be measured daily. In this embodiment, the joint swelling degree is normalized to a value within the range of 0-1 to eliminate dimensions and facilitate subsequent data processing. In one exemplary embodiment, this embodiment may employ a maximum and minimum value normalization method. The maximum and minimum values involved in this method are determined by the doctor's assessment of the patient's actual joint condition. For example, the maximum value represents the maximum degree of joint swelling determined by the doctor's assessment. When the actual joint swelling exceeds this maximum degree, it indicates a serious joint abnormality requiring immediate treatment, and the data processing procedure of this embodiment is no longer executed. The minimum value represents the minimum degree of joint swelling determined by the doctor's assessment, i.e., normal joint data with no swelling. All joint swelling levels mentioned below are normalized and dimensionless data.
[0022] Fluctuations in human hormone levels can affect joint repair. For example, cortisol, as a stress hormone, can suppress inflammatory responses and cell proliferation if its level remains excessively high for an extended period, hindering the repair process promoted by PRP. Multiple cortisol level samples should be collected before the most recent PRP administration. The sampling frequency for cortisol levels can be higher than that for C-reactive protein levels; for instance, cortisol levels can be measured daily. Cortisol levels can be collected via blood or saliva. To ensure ease of collection, this embodiment uses non-invasive saliva collection, suitable for home use, and the unit is nmol / L. Because cortisol secretion has a diurnal rhythm, the measured values may differ at different times of the day; therefore, the collection time should be consistent each time, for example, always at 11 PM. This embodiment normalizes cortisol levels to a value range of 0-1 to eliminate dimensions and facilitate subsequent data processing. In one exemplary embodiment, this embodiment may employ a maximum and minimum value normalization method. The maximum and minimum values involved in this method are set according to actual conditions. For example, the maximum value is the theoretical maximum cortisol level at the corresponding data collection time, and the minimum value is the theoretical minimum cortisol level at the corresponding data collection time. When the actual cortisol level in a person is higher than the theoretical maximum or lower than the theoretical minimum, it indicates a serious abnormality, requiring immediate treatment, and the data processing procedure of this embodiment will not be executed. All cortisol levels mentioned below are normalized and dimensionless data.
[0023] like Figure 1 As shown in this embodiment, a method for evaluating the concentration of PRP for joint motion injury repair is provided, comprising the following steps: Step S1: Based on the changes in C-reactive protein levels before the most recent PRP administration, obtain the overall inflammatory repair manifestations; Step S2: Based on the changes in the degree of joint swelling within each detection segment, obtain the joint swelling repair characteristics of each detection segment; Step S3: Determine the correlation between joint swelling repair characteristics and changes in C-reactive protein levels, and combine the joint swelling repair characteristics with the comprehensive inflammation repair performance to obtain the comprehensive repair effect characteristics; Step S4: Based on the abnormal cortisol levels observed multiple times prior to the most recent PRP administration, obtain the hormone level deviation characteristics; Step S5: Adjust the concentration of the next PRP administration based on the characteristics of the overall repair effect and the deviation characteristics of hormone levels.
[0024] The following detailed explanation of each step, in conjunction with the accompanying drawings, is provided.
[0025] Step S1: Based on the changes in C-reactive protein levels before the most recent PRP administration, obtain the overall inflammatory repair performance.
[0026] In healthy individuals, C-reactive protein (CRP) levels are typically low. Following a joint injury, the damaged tissue triggers an inflammatory response, leading to an increase in CRP levels. The magnitude of this increase is correlated with the severity of the injury; generally, the more severe the injury, the more pronounced the increase. As repair progresses, growth factors in PRP promote tissue repair and reduce inflammation, causing a decrease in blood CRP levels. Once the inflammation has largely subsided, CRP levels tend to stabilize. However, when repair is ineffective, PRP fails to effectively activate the repair mechanism, and CRP levels will not show a significant decrease.
[0027] C-reactive protein (CRP) levels were obtained from each CRP level test prior to the most recent PRP administration. The overall inflammation repair performance was then determined based on the changes in CRP levels. The overall inflammation repair performance reflects the progress of inflammation repair as a whole; a greater decrease in CRP levels indicates better inflammation repair and a higher overall inflammation repair performance. In one exemplary embodiment, the CRP levels prior to the most recent PRP administration were arranged chronologically to obtain a CRP level sequence. Then, the first and last CRP levels in the sequence were determined, and the difference between the first and last CRP levels was calculated to determine the overall inflammation repair performance. A larger difference indicates a greater decrease in the last CRP level relative to the first, indicating better inflammation repair and a higher overall inflammation repair performance. Therefore, the overall inflammation repair performance is positively correlated with this difference. Based on the above logic, the following is a specific calculation method for the comprehensive inflammation repair performance: normalize the difference using the sigmoid function, and the normalized result is the comprehensive inflammation repair performance.
[0028] Step S2: Based on the changes in the degree of joint swelling in each detection segment, obtain the joint swelling repair characteristics of each detection segment.
[0029] Because the sampling frequency for C-reactive protein levels is lower than that for the sampling frequency for joint swelling, for any two adjacent C-reactive protein levels, the degree of joint swelling will be measured several times during the time interval between the two adjacent C-reactive protein levels.
[0030] Since C-reactive protein (CRP) levels are not measured daily, step S1 only uses interim data to obtain comprehensive inflammatory repair performance, ignoring the dynamic changes in inflammation between two consecutive CRP levels. Furthermore, CRP levels are not only affected by inflammation during joint injury repair; infections or trauma to other systems can also cause them to rise. For example, if a patient catches a cold during joint injury treatment, the inflammation caused by the cold will raise CRP levels. This increase is not caused by joint injury inflammation but will be reflected in the comprehensive inflammatory repair performance, interfering with the judgment of the joint injury repair effect. Therefore, changes in CRP levels cannot fully reflect the patient's repair status, and a more accurate assessment of the repair effect is needed by combining daily joint swelling levels.
[0031] The time interval between two consecutive C-reactive protein (CRP) level readings is defined as a detection segment, resulting in multiple detection segments. Within each detection segment, several measurements of joint swelling are performed. In this embodiment, the day on which two consecutive CRP level measurements occur is also included in the detection segment. For example, if CRP levels are measured weekly and joint swelling is measured daily, eight measurements of joint swelling will be performed within each detection segment.
[0032] For any detection segment, the joint swelling levels detected daily within that segment are arranged chronologically to obtain a joint swelling level sequence, thus yielding a joint swelling level sequence corresponding to that detection segment. Based on the changes in joint swelling levels within that detection segment, the joint swelling repair characteristics of that segment are obtained. In an exemplary embodiment, such as... Figure 2 As shown, the following is a specific process for obtaining joint swelling repair features: Step S21: Determine the degree of joint swelling sequence to show the worsening of joint swelling.
[0033] Based on the joint swelling degree sequence of the detection segment, the aggravation of joint swelling in that segment is obtained. The aggravation of joint swelling characterizes the increase in the degree of joint swelling in that detection segment. When the repair effect is good, the degree of joint swelling decreases and the swelling area shrinks; while when the repair effect is poor, the degree of joint swelling does not change significantly, or it worsens or recurs. In an exemplary embodiment, the first-order difference sequence of the joint swelling degree sequence is determined, and each positive number in the first-order difference sequence is obtained. If the treatment effect is good, the first-order difference sequence is all negative, indicating that the inflammation is well controlled and the repair effect shows good signs; conversely, if there are positive numbers in the first-order difference sequence, it indicates that the degree of joint swelling has worsened, and the more numerous and larger the positive numbers, the more frequent and severe the aggravation of swelling in that detection segment, reflecting a poor joint injury repair effect.
[0034] The average value of the positive values in the first-order difference sequence is calculated. Based on the average value of the positive values in the first-order difference sequence, the aggravated joint swelling of the detection segment is obtained. As analyzed above, the larger the average value of the positive values in the first-order difference sequence, the stronger the aggravated joint swelling of the detection segment; the two are positively correlated. In an exemplary embodiment, the average value of the positive values in the first-order difference sequence of the joint swelling degree sequence of the detection segment is used as the aggravated joint swelling of the detection segment. It should be understood that if there are no positive values in the first-order difference sequence, the aggravated joint swelling is 0.
[0035] Step S22: Determine whether there is a period of continuous worsening of swelling in the joint swelling degree sequence.
[0036] Based on the joint swelling degree sequence of the detection segment, determine whether there is a period of continuous increase in swelling in the joint swelling degree sequence. The period of continuous increase in swelling indicates that the joint swelling degree in the detection segment continues to increase, and is the time period of continuous increase in joint swelling degree in the detection segment.
[0037] Since the positive numbers in the first-order difference sequence of the joint swelling degree sequence of the detection segment indicate that the joint swelling degree is increasing, at least two consecutive positive numbers appearing in time are determined from each positive number in the first-order difference sequence, and the corresponding positions of the consecutive positive numbers in the first-order difference sequence in the joint swelling degree sequence are determined. The time period formed by these corresponding positions is taken as the period of continuous swelling aggravation. As an example: If the positive numbers in the first-order difference sequence are 2, 3, 4, and 7 respectively, then the consecutive positive numbers in the first-order difference sequence are the 2nd, 3rd, and 4th positions in the first-order difference sequence. Since each element in the first-order difference sequence is the difference between the previous and subsequent data, the corresponding positions of the 2nd, 3rd, and 4th positions in the first-order difference sequence are the 2nd, 3rd, 4th, and 5th positions in the joint swelling degree sequence. Therefore, the time period consisting of the 2nd, 3rd, 4th, and 5th positions in the joint swelling degree sequence is considered as the period of continuous worsening of swelling.
[0038] If there are at least two consecutive periods of worsening swelling in the sequence of joint swelling severity, the longest of these consecutive periods is taken as the desired consecutive period of worsening swelling. Subsequent periods of worsening swelling are used for data processing based on their duration. Therefore, if there are multiple longest consecutive periods of worsening swelling, or if all consecutive periods of worsening swelling have the same length, any one of them can be selected.
[0039] It should be understood that if there are no consecutive positive numbers in the first-order difference sequence of the joint swelling degree sequence in the detection segment, then there is no period of continuous aggravation of swelling in the joint swelling degree sequence.
[0040] Step S23: If there is a period of continuous worsening of swelling in the joint swelling degree sequence, then the joint swelling repair characteristics are obtained based on the duration of the period of continuous worsening of swelling and the manifestation of joint swelling worsening.
[0041] If the joint swelling degree sequence in the detection segment contains a period of continuously worsening swelling, the duration of this period is obtained, i.e., the number of data points contained within it. Based on the duration of this period and the severity of joint swelling, joint swelling repair features are obtained. A longer duration of this period indicates a poorer joint swelling repair effect and a lower joint swelling repair feature; the joint swelling repair feature is inversely correlated with the duration of the continuously worsening swelling period. Conversely, a stronger severity of joint swelling indicates a poorer joint swelling repair effect and a lower joint swelling repair feature; the joint swelling repair feature is inversely correlated with the severity of joint swelling. Based on the above logic, a specific calculation method for joint swelling repair features is given below: ; in, This indicates the joint swelling repair characteristics, where 'e' represents the duration corresponding to the joint swelling degree sequence in this detection segment (i.e., the time interval between the time corresponding to the last data in the joint swelling degree sequence of this detection segment and the time corresponding to the first data). This indicates the duration of the period in which the swelling continues to worsen within the joint swelling sequence detected. This indicates the proportion of the duration of progressively worsening swelling within the total duration of the joint swelling severity sequence, which is equivalent to the percentage of the total duration of the swelling. Normalization; This indicates worsening joint swelling. This represents the normalization function. As a specific example, the maximum-minimum normalization method is used to normalize the worsening of joint swelling.
[0042] Step S24: If there is no period of continuous worsening of swelling in the joint swelling degree sequence, then determine the period of continuous relief of swelling in the joint swelling degree sequence. Based on the duration of the period of continuous relief of swelling and the manifestation of joint swelling worsening, obtain the joint swelling repair characteristics.
[0043] If there is no period of continuously worsening swelling in the joint swelling degree sequence of the detection segment, then the period of continuously relieved swelling in the joint swelling degree sequence of the detection segment is obtained. The meaning of the period of continuously relieved swelling is the opposite of that of the period of continuously worsening swelling. The period of continuously relieved swelling indicates that the degree of joint swelling in the detection segment is continuously decreasing, and is the time period of continuously decreasing joint swelling in the detection segment. Since negative numbers in the first-order difference sequence of the joint swelling degree sequence of the detection segment represent a decrease in the degree of joint swelling, the process is similar to obtaining the period of continuously worsening swelling. Each negative number in the first-order difference sequence of the joint swelling degree sequence of the detection segment is obtained, at least two consecutive negative numbers appearing in time are determined, and the corresponding positions of the consecutively appearing negative numbers in the first-order difference sequence in the joint swelling degree sequence are determined. The time period formed by these corresponding positions is taken as the period of continuously relieved swelling. As an example: If the negative numbers in the first-order difference sequence are 1, 3, 4, and 6 respectively, then the consecutive positive numbers in the first-order difference sequence are the 3rd and 4th positions in the first-order difference sequence. Therefore, the corresponding positions of the 3rd and 4th positions in the first-order difference sequence are the 3rd, 4th, and 5th positions in the joint swelling degree sequence. Thus, the time period formed by the 3rd, 4th, and 5th positions in the joint swelling degree sequence is considered as the period of continuous swelling relief.
[0044] Similarly, if the joint swelling degree sequence contains at least two periods of sustained swelling relief, the longest of these periods is selected as the desired sustained swelling relief period. Subsequent sustained swelling relief periods are used for data processing based on their duration. If multiple longest sustained swelling relief periods exist, or if all sustained swelling relief periods have the same length, any one of them can be chosen. Conversely, if the joint swelling degree sequence does not contain any sustained swelling relief periods, the duration of a sustained swelling relief period is set to 1.
[0045] The longer the period of sustained swelling relief, the better the joint swelling repair effect and the higher the joint swelling repair characteristic. The joint swelling repair characteristic is positively correlated with the duration of sustained swelling relief. Conversely, the stronger the worsening of joint swelling, the worse the joint swelling repair effect and the lower the joint swelling repair characteristic. The joint swelling repair characteristic is inversely correlated with the worsening of joint swelling. Based on the above logic, a specific calculation method for the joint swelling repair characteristic is given below: ; in, This indicates the duration of the period during which the swelling continues to subside. This indicates the proportion of the duration of the swelling relief period within the total duration of the joint swelling severity sequence, which is equivalent to the percentage of the total swelling severity period within the total swelling severity sequence. Normalization.
[0046] Therefore, based on whether there are periods of continuously worsening swelling in the joint swelling degree sequence of the detection segment, the joint swelling repair characteristics of that detection segment are obtained. This leads to the acquisition of joint swelling repair characteristics for each detection segment.
[0047] Step S3: Determine the correlation between joint swelling repair characteristics and changes in C-reactive protein levels, and combine the joint swelling repair characteristics with the comprehensive inflammation repair performance to obtain the comprehensive repair effect characteristics.
[0048] The joint swelling repair features of each detection segment were sorted according to time sequence to obtain the joint swelling repair feature sequence. The correlation between the joint swelling repair feature sequence and the C-reactive protein level sequence was obtained. The higher the correlation, the more synchronized the changes of the two are, the less the changes of C-reactive protein level are affected by other factors, and the more reliable the repair effect shown by the two.
[0049] In an exemplary embodiment, the correlation of change can be obtained as follows: Since a stronger comprehensive feature of joint swelling repair leads to a better repair effect, and C-reactive protein levels should continuously decrease during the repair process, a negative correlation mapping is performed on the data in the C-reactive protein level sequence to obtain a C-reactive protein negative correlation mapping sequence. The DTW (Dynamic Time Warping) distance between the joint swelling repair feature sequence and the C-reactive protein negative correlation mapping sequence is calculated. The DTW distance represents the difference between the two, and then the DTW distance is negatively normalized to obtain the correlation of change. The negative correlation normalization method here can be: ,in, The function DTW represents the DTW distance between the joint swelling repair feature sequence and the C-reactive protein (CRP) level sequence, with the natural constant as the base. The CRP negative correlation mapping sequence is a data sequence obtained by performing negative correlation mapping on each data point in the CRP level sequence. When performing negative correlation mapping on each data point in the CRP level sequence, the value of the exponential function with the natural constant as the base and the negative exponent of each data point in the CRP level sequence can be used as the negative correlation mapping result.
[0050] The joint swelling repair characteristics of each detection segment are integrated to obtain the comprehensive joint swelling repair characteristics. Specifically, the average value of the joint swelling repair characteristics of each detection segment is calculated, and the result is the comprehensive joint swelling repair characteristics.
[0051] The comprehensive repair effect characteristics are derived based on the correlation between changes in joint swelling repair feature sequences and C-reactive protein (CRP) level sequences, the comprehensive characteristics of joint swelling repair, and the comprehensive inflammatory repair manifestations. A higher correlation between the joint swelling repair feature sequences and CRP level sequences indicates that the changes in CRP levels are not influenced by other factors, the repair effect is more reliable, and the comprehensive repair effect characteristics are stronger. The comprehensive repair effect characteristics are positively correlated with the aforementioned correlation. The comprehensive joint swelling repair characteristics reflect the repair effect from the degree of joint swelling relief (i.e., clinical manifestations). A stronger comprehensive joint swelling repair characteristic indicates a better repair effect, and the comprehensive repair effect characteristics are positively correlated with the comprehensive joint swelling repair characteristics. The comprehensive inflammatory repair manifestations reflect the repair effect from the decrease in CRP levels (i.e., laboratory indicators). A stronger comprehensive inflammatory repair manifestation indicates a better repair effect, and the comprehensive repair effect characteristics are stronger. The comprehensive repair effect characteristics are positively correlated with the comprehensive inflammatory repair manifestations. Based on the above logic, a specific calculation method for the comprehensive repair effect characteristics is given below: calculate the geometric mean of the correlation of changes, the comprehensive joint swelling repair characteristics, and the comprehensive inflammatory repair manifestations; the result is used as the comprehensive repair effect characteristics.
[0052] Step S4: Based on the abnormal cortisol levels observed multiple times prior to the most recent PRP administration, obtain the hormone level deviation characteristics.
[0053] During the repair process, in addition to each PRP administration, the patient's own physical condition, such as fluctuations in metabolic and hormone levels, will also have a certain impact on the repair effect. In order to improve the repair effect, when adjusting the concentration of the next PRP administration, in addition to considering the comprehensive repair effect characteristics reflected by clinical manifestations and laboratory indicators, it is also necessary to consider the patient's physical condition during the repair period and adjust the PRP administration concentration accordingly.
[0054] The abnormality of cortisol levels prior to the most recent PRP administration is identified, resulting in a hormone level deviation characteristic. This characteristic characterizes the extent to which cortisol levels deviate from the normal range multiple times. In an exemplary embodiment, such as... Figure 3 As shown, the following is a specific process for obtaining hormone level deviation features: Step S41: Determine the severity of multiple cortisol hormone levels.
[0055] The severity of cortisol levels prior to the most recent PRP administration is determined. In an exemplary embodiment, a two-dimensional coordinate system is constructed with each cortisol level measurement as the x-axis and cortisol levels as the y-axis, mapping each cortisol level onto this coordinate system. A linear regression is then performed on each cortisol level, and the slope of the fitted line is determined. This slope characterizes the overall trend of cortisol levels over time; the slope can be positive or negative. This embodiment considers the sign of the slope value. A smaller slope value indicates a more significant downward trend in cortisol levels, indicating improved physical condition and lower severity of cortisol levels. Conversely, a larger slope value indicates a less significant downward trend in cortisol levels, less effective physical relief, and higher severity of cortisol levels. Therefore, the slope is normalized using a sigmoid function, and the normalized result represents the severity of cortisol levels.
[0056] Step S42: Determine the overall deviation of cortisol levels based on the relationship between the maximum, minimum, and last cortisol levels in multiple cortisol level readings and the preset normal range for cortisol.
[0057] The pre-defined normal range for cortisol hormone is established, representing the range of cortisol levels in the human body under normal conditions. It should be understood that the pre-defined normal range for cortisol hormone is also normalized and dimensionless (the normalization method is the same as that used for cortisol levels mentioned above), facilitating comparison with different cortisol levels. When cortisol levels are higher than the upper limit of the pre-defined normal range, it indicates excessively high cortisol levels, which can hinder the PRP-promoted repair process and slow down the repair speed. When cortisol levels are lower than the lower limit of the pre-defined normal range, it indicates excessively low cortisol levels, which can affect the body's stress regulation ability, leading to insufficient repair response to injury, and is also detrimental to the repair of joint injuries. It should be understood that after a joint injury occurs, cortisol secretion increases, and then as repair progresses, cortisol levels gradually decrease, approaching the normal range.
[0058] The maximum and minimum cortisol levels (the lowest values among multiple cortisol levels) are determined from a series of data points. The last cortisol level in the time sequence is also determined. Based on the relationship between the maximum, minimum, and last cortisol levels and the pre-defined normal range for cortisol levels, the overall deviation from the target range is determined.
[0059] For clarity, candidate cortisol levels are defined as any one of the maximum, minimum, and last cortisol levels.
[0060] Based on the relationship between candidate cortisol levels and the preset normal range for cortisol, the degree of deviation of the candidate cortisol level is determined. Specifically, if the candidate cortisol level is greater than the upper limit of the preset normal range, it indicates that the candidate cortisol level exceeds the preset normal range. In this case, the upper limit of the preset normal range is subtracted from the candidate cortisol level, and the difference is taken as the degree of deviation. If the candidate cortisol level is within the preset normal range (i.e., the candidate cortisol level is less than or equal to the upper limit of the preset normal range and greater than or equal to the lower limit of the preset normal range), the degree of deviation is 0. If the candidate cortisol level is less than the lower limit of the preset normal range, the candidate cortisol level is subtracted from the lower limit of the preset normal range, and the difference is taken as the degree of deviation. Through the above calculations, the difference is ensured to be greater than 0.
[0061] Using the above process, the deviations of cortisol levels at the maximum, minimum, and last cortisol levels can be obtained separately. The deviation at the maximum cortisol level is defined as the first cortisol level deviation, the deviation at the minimum cortisol level is defined as the second cortisol level deviation, and the deviation at the last cortisol level is defined as the third cortisol level deviation. The first, second, and third cortisol level deviations are then combined by calculating their average values, resulting in the comprehensive cortisol level deviation.
[0062] The deviations in the levels of the first, second, and third cortisol hormones are explained in detail below.
[0063] If the maximum cortisol level is greater than the upper limit of the preset normal range for cortisol, the difference between the maximum cortisol level and the upper limit of the preset normal range for cortisol is calculated to obtain the first degree of cortisol level deviation; if the maximum cortisol level is within the preset normal range for cortisol, the first degree of cortisol level deviation is 0; if the maximum cortisol level is less than the lower limit of the preset normal range for cortisol, the difference between the lower limit of the preset normal range for cortisol and the maximum cortisol level is calculated to obtain the first degree of cortisol level deviation.
[0064] If the minimum cortisol level is less than the lower limit of the preset normal range for cortisol, the difference between the lower limit and the minimum cortisol level is calculated to obtain the second degree of cortisol level deviation. If the minimum cortisol level is within the preset normal range for cortisol, the second degree of cortisol level deviation is 0. If the minimum cortisol level is greater than the upper limit of the preset normal range for cortisol, the difference between the minimum cortisol level and the upper limit of the preset normal range for cortisol is calculated to obtain the second degree of cortisol level deviation.
[0065] If the last cortisol level is less than the lower limit of the preset normal range for cortisol, the difference between the lower limit of the preset normal range and the last cortisol level is calculated to obtain the deviation of the third cortisol level; if the last cortisol level is within the preset normal range for cortisol, the deviation of the third cortisol level is 0; if the last cortisol level is greater than the upper limit of the preset normal range for cortisol, the difference between the last cortisol level and the upper limit of the preset normal range for cortisol is calculated to obtain the deviation of the third cortisol level.
[0066] Step S43: Obtain the hormone level deviation characteristics by combining the severity and the degree of deviation of cortisol hormone levels.
[0067] The higher the severity of cortisol levels, the greater the degree of deviation in hormone levels, and the stronger the deviation characteristic. The deviation characteristic is positively correlated with the severity of cortisol levels. Similarly, the higher the overall degree of deviation in cortisol levels, the stronger the deviation characteristic, and the deviation characteristic is positively correlated with the overall degree of deviation. Based on this logic, a specific method for calculating the deviation characteristic is as follows: calculate the product of the severity of cortisol levels and the overall degree of deviation; the result is the deviation characteristic.
[0068] Step S5: Adjust the concentration of the next PRP administration based on the characteristics of the overall repair effect and the deviation characteristics of hormone levels.
[0069] The overall repair effect characteristics and hormone level deviation characteristics are used as the basis for adjusting the next PRP dosage. In an exemplary embodiment, the patient's current repair homeostasis characteristics are obtained based on the overall repair effect characteristics and hormone level deviation characteristics. A stronger overall repair effect characteristic indicates a better overall repair status and a stronger repair homeostasis characteristic; the two are positively correlated. A stronger hormone level deviation characteristic indicates a greater deviation of cortisol levels from the normal range, a worse overall repair status, and a weaker repair homeostasis characteristic; the two are inversely correlated. Based on the above logic, the following is a method for calculating the repair homeostasis characteristics: ; in, This indicates the restoration of steady-state characteristics. Indicates the overall repair effect characteristics, This indicates a deviation in hormone levels from the expected range.
[0070] Therefore, by obtaining laboratory indicators from a period of time prior to the patient's most recent PRP administration, the overall inflammatory repair manifestations can be determined. Combined with changes in the patient's clinical manifestations, the characteristics of the overall repair effect can be determined. Furthermore, based on changes in cortisol hormone levels, the patient's current physical condition can be analyzed to ultimately determine the patient's current repair homeostasis characteristics.
[0071] Finally, the concentration of PRP for the next administration is determined based on the obtained repair homeostasis characteristics. The stronger the repair homeostasis characteristics, the higher the repair effect and the better the patient's physical condition. Therefore, a higher concentration of PRP is less needed for further stimulation, allowing the body to adapt to the repair process and avoiding interference with repair due to excessive PRP concentration. Thus, the concentration of PRP for the next administration should be reduced.
[0072] This embodiment presets a repair steady-state characteristic threshold, which is used to determine whether the repair steady-state characteristic is too high. The value range of this preset repair steady-state characteristic threshold is 0-1, and the specific value is set according to the actual judgment needs. This embodiment uses 0.45 as an example.
[0073] The difference between the repair steady-state characteristic and a preset repair steady-state characteristic threshold is determined. Specifically, the repair steady-state characteristic difference is the absolute value of the difference between the repair steady-state characteristic and the preset repair steady-state characteristic threshold. Based on the repair steady-state characteristic difference and the most recent PRP dosage concentration, the adjustment range of the PRP dosage concentration is obtained. In an exemplary embodiment, the product of the repair steady-state characteristic difference and the most recent PRP dosage concentration is calculated as the adjustment range of the PRP dosage concentration.
[0074] The repair steady-state characteristic is compared with the preset repair steady-state characteristic threshold. If the repair steady-state characteristic is greater than or equal to the preset repair steady-state characteristic threshold, it indicates a good repair effect, and the PRP dosage concentration needs to be reduced. In this case, the adjustment range of the PRP dosage concentration is subtracted from the most recent PRP dosage concentration, and the difference is used as the next PRP dosage concentration. It should be understood that the larger the repair steady-state characteristic is compared to the preset repair steady-state characteristic threshold, the better the repair effect. The greater the difference in the repair steady-state characteristic, the larger the adjustment range of the PRP dosage concentration. The smaller the difference between the most recent PRP dosage concentration and the adjustment range, the smaller the next PRP dosage concentration will be.
[0075] If the repair steady-state characteristic is less than the preset repair steady-state characteristic threshold, it indicates a poor repair effect, requiring an increase in PRP concentration. In this case, the most recent PRP concentration is added to the adjustment range of the obtained PRP concentration, and this sum is used as the next PRP concentration. It should be understood that the smaller the repair steady-state characteristic is than the preset repair steady-state characteristic threshold, the worse the repair effect; the greater the difference in repair steady-state characteristics, the larger the adjustment range of the PRP concentration; and the larger the sum of the most recent PRP concentration and the adjustment range, the greater the increase in PRP concentration, and the higher the next PRP concentration.
[0076] It should be noted that after determining the concentration of the next PRP administration, it is necessary to determine whether it is within the preset effective and safe concentration range. If the calculated result is greater than the upper limit of the concentration range, the concentration of the next PRP administration will be determined as the upper limit value; if the calculated result is less than the lower limit of the concentration range, the concentration of the next PRP administration will be determined as the lower limit value.
[0077] Example of a device for evaluating PRP dosage concentration for joint motion injury repair: A structural block diagram of a PRP administration concentration assessment device for joint motion injury repair provided in one embodiment of the present invention. The device may include a repair performance evaluation module, a repair characteristic determination module, a repair effect determination module, a hormone level deviation assessment module, and an administration concentration adjustment module.
[0078] Among them, the repair performance evaluation module is used to obtain the comprehensive inflammation repair performance based on the changes in C-reactive protein levels multiple times before the most recent PRP administration. The repair feature determination module is used to obtain the joint swelling repair features of each detection segment based on the changes in the degree of joint swelling within each detection segment; the detection segment is the time period between two adjacent C-reactive protein levels; The repair effect determination module is used to determine the correlation between joint swelling repair characteristics and changes in C-reactive protein levels, and to obtain comprehensive repair effect characteristics by combining the joint swelling repair characteristics and the comprehensive inflammation repair performance. The hormone level deviation assessment module is used to obtain hormone level deviation characteristics based on multiple abnormalities in cortisol hormone levels before the most recent PRP administration. The dosage concentration adjustment module is used to adjust the concentration of the next PRP administration based on the characteristics of the overall repair effect and the deviation characteristics of hormone levels.
[0079] It should be understood that the structural block diagram and modules of the device for assessing PRP dosage concentration for joint motion injury repair can be implemented in various ways. For example, in some embodiments, the device and its modules can be implemented in hardware, software, or a combination of both. The hardware portion can be implemented using dedicated logic; the software portion can be stored in memory and executed by appropriate instructions, such as a microprocessor or dedicated hardware. Those skilled in the art will understand that the above-described methods and devices can be implemented using computer-executable instructions and / or included in processor control code, for example, on a carrier medium such as a disk, CD, or DVD-ROM, a programmable memory such as read-only memory (firmware), or a data carrier such as an optical or electronic signal carrier. The devices and modules of this specification can be implemented not only with hardware circuits such as very large-scale integrated circuits or gate arrays, semiconductors such as logic chips, transistors, or programmable hardware devices such as field-programmable gate arrays, programmable logic devices, etc., but also with software, for example, executed by various types of processors, or with a combination of the above-described hardware circuits and software (e.g., firmware).
[0080] For more details about the above modules, please refer to other parts of this manual; they will not be repeated here.
[0081] It should be noted that the order of the above embodiments of the present invention is merely for descriptive purposes and does not represent the superiority or inferiority of the embodiments. The processes depicted in the accompanying drawings do not necessarily require a specific or sequential order to achieve the desired result. In some embodiments, multitasking and parallel processing are also possible or may be advantageous.
[0082] The various embodiments in this specification are described in a progressive manner. The same or similar parts between the various embodiments can be referred to each other. Each embodiment focuses on describing the differences from other embodiments.
Claims
1. A method for evaluating the concentration of PRP administered for the repair of joint motion injuries, characterized in that, include: Based on the changes in C-reactive protein levels multiple times prior to the most recent PRP administration, the overall inflammatory repair profile was obtained. Based on the changes in the degree of joint swelling within each detection segment, the joint swelling repair characteristics of each detection segment are obtained; the detection segment is the time period between two adjacent C-reactive protein levels. The correlation between joint swelling repair characteristics and changes in C-reactive protein levels was determined, and the comprehensive repair effect characteristics were obtained by combining the joint swelling repair characteristics with the comprehensive inflammation repair manifestations. Based on the abnormal cortisol hormone levels observed multiple times prior to the most recent PRP administration, the hormone level deviation characteristics were obtained. The concentration of PRP for the next administration will be adjusted based on the overall repair effect characteristics and the deviation characteristics of hormone levels.
2. The method for evaluating the concentration of PRP for joint motion injury repair as described in claim 1, characterized in that, The process of obtaining the comprehensive inflammatory repair manifestations includes: The difference between the first and last C-reactive protein levels in the multiple C-reactive protein levels is determined, and the comprehensive inflammation repair performance is obtained based on the difference; the comprehensive inflammation repair performance is positively correlated with the difference.
3. The method for evaluating the concentration of PRP for joint motion injury repair as described in claim 1, characterized in that, The process of obtaining the joint swelling repair characteristics includes: The joint swelling degree sequence is used to determine the worsening manifestation of joint swelling, wherein the joint swelling degree sequence is obtained by arranging the joint swelling degree within the detection segment in chronological order; Determine whether there is a period of continuously worsening swelling in the sequence of joint swelling degrees, wherein the period of continuously worsening swelling indicates that the degree of joint swelling continues to increase; If there is a period of continuous worsening of swelling in the joint swelling degree sequence, then the joint swelling repair characteristics are obtained based on the duration of the period of continuous worsening of swelling and the manifestation of joint swelling worsening; the joint swelling repair characteristics are inversely correlated with the duration of the period of continuous worsening of swelling and the manifestation of joint swelling worsening. If there is no period of continuous worsening of swelling in the joint swelling degree sequence, then a period of continuous relief of swelling in the joint swelling degree sequence is determined. Based on the duration of the period of continuous relief of swelling and the manifestation of worsening joint swelling, the joint swelling repair characteristics are obtained. The joint swelling repair characteristics are positively correlated with the duration of the period of continuous relief of swelling and negatively correlated with the manifestation of worsening joint swelling.
4. The method for evaluating the concentration of PRP for joint motion injury repair as described in claim 3, characterized in that, The process of obtaining the description of increased joint swelling includes: Determine the first-order difference sequence of the joint swelling degree sequence, and calculate the average value of the positive numbers in the first-order difference sequence; The worsening of joint swelling is obtained based on the average value of the positive numbers in the first-order difference sequence.
5. The method for evaluating the concentration of PRP for joint motion injury repair as described in claim 4, characterized in that, The process of obtaining the period during which the swelling continues to worsen includes: The corresponding positions of consecutively occurring positive numbers in the first-order difference sequence in the joint swelling degree sequence are determined as the period of continuous worsening of swelling; The process of obtaining the period of sustained swelling relief includes: The corresponding positions of consecutively occurring negative numbers in the first-order difference sequence in the joint swelling degree sequence are determined as the period of sustained swelling relief.
6. The method for evaluating the concentration of PRP for joint motion injury repair as described in claim 1, characterized in that, The process of obtaining the comprehensive repair effect characteristics includes: By integrating the joint swelling repair characteristics of each detection segment, a comprehensive feature of joint swelling repair is obtained; The comprehensive repair effect characteristics are obtained based on the correlation of changes, the comprehensive characteristics of joint swelling repair, and the comprehensive inflammation repair performance; the comprehensive repair effect characteristics are all positively correlated with the correlation of changes, the comprehensive characteristics of joint swelling repair, and the comprehensive inflammation repair performance.
7. The method for evaluating the concentration of PRP for joint motion injury repair as described in claim 1, characterized in that, The process of obtaining the hormone level deviation characteristics includes: Determine the severity of the repeated cortisol hormone levels; The overall deviation of cortisol levels is determined based on the relationship between the maximum, minimum, and last cortisol levels in the multiple cortisol level readings and the preset normal range for cortisol levels. The deviation characteristics of the hormone levels are obtained by combining the severity and the degree of deviation of the cortisol hormone levels.
8. The method for evaluating the concentration of PRP for joint motion injury repair as described in claim 7, characterized in that, The process of obtaining the overall deviation of the cortisol hormone level includes: The degree of deviation of a candidate cortisol level is determined by the relationship between the candidate cortisol level and the preset normal range of cortisol levels. Specifically, if the candidate cortisol level is greater than the upper limit of the preset normal range, the difference between the candidate cortisol level and the upper limit is calculated to obtain the degree of deviation. If the candidate cortisol level is within the preset normal range, the degree of deviation is 0. If the candidate cortisol level is less than the lower limit of the preset normal range, the difference between the lower limit and the candidate cortisol level is calculated to obtain the degree of deviation. The candidate cortisol level can be any one of the maximum, minimum, and last cortisol levels. The overall deviation of the cortisol level is obtained by combining the deviations of the maximum, minimum, and last cortisol levels.
9. The method for evaluating the concentration of PRP for joint motion injury repair as described in claim 1, characterized in that, The adjustment of the next PRP dosage concentration based on the comprehensive repair effect characteristics and hormone level deviation characteristics includes: Based on the comprehensive repair effect characteristics and hormone level deviation characteristics, the repair homeostasis characteristics are obtained; the repair homeostasis characteristics are positively correlated with the comprehensive repair effect characteristics and negatively correlated with the hormone level deviation characteristics. The concentration of the next PRP administration will be determined based on the repair homeostasis characteristics.
10. The method for evaluating the concentration of PRP for joint motion injury repair as described in claim 9, characterized in that, The determination of the next PRP dosage concentration based on the repair homeostasis characteristics includes: The adjustment range of the PRP administration concentration is obtained based on the difference between the repair steady-state characteristics and the preset repair steady-state characteristic threshold, and the most recent PRP administration concentration. The repair steady-state characteristic is compared with a preset repair steady-state characteristic threshold. If the repair steady-state characteristic is greater than or equal to the preset repair steady-state characteristic threshold, the difference between the most recent PRP administration concentration and the adjustment range is determined as the next PRP administration concentration. If the repair steady-state characteristic is less than the preset repair steady-state characteristic threshold, the sum of the most recent PRP administration concentration and the adjustment range is determined as the next PRP administration concentration.