Classification report and treatment guidance system for hidden obstructive hypertrophic cardiomyopathy

Abstract

The invention provides a hidden obstructive hypertrophic cardiomyopathy grading report and treatment guidance system, and the system comprises an object screening module which is used for screening object samples meeting a preset screening index from pre-obtained object samples, and obtaining a to-be-analyzed object sample set; the index acquisition module is used for performing a motion load test on each object in the to-be-analyzed object sample set and monitoring a biological index of each object in the load test process; the index grading report module is used for dividing the biological indexes into grading indexes and disposal guidance indexes, and generating a corresponding first index grading report, a corresponding second index grading report and a corresponding third index grading report according to different grading conditions; and the disposal guidance module is used for generating a corresponding disposal guidance scheme through the disposal guidance indexes based on the first index grading report, the second index grading report or the third index grading report. According to the method, the cycle management reliability of the hidden obstructive hypertrophic cardiomyopathy is improved.

Description

Technical Field

[0001] This invention relates to the field of intelligent data processing, and in particular to a grading, reporting, and treatment guidance system for occult obstructive hypertrophic cardiomyopathy. Background Technology

[0002] Occult obstructive hypertrophic cardiomyopathy (HOCM) is a subtype of hypertrophic cardiomyopathy characterized by asymmetric myocardial hypertrophy. At rest, there is no obvious obstruction of the left ventricular outflow tract, but under specific triggers such as exercise or emotional excitement, obstruction of the left ventricular outflow tract may occur, leading to a significant decrease in effective cardiac output. Furthermore, the symptoms may vary among individuals. Therefore, accurately classifying, reporting, and providing management guidelines for HOCM is a pressing issue in current clinical research.

[0003] Currently, existing technologies primarily employ stress stimulation methods such as the Valsalva maneuver and squat-stand test to determine whether the left ventricular outflow tract pressure gradient meets the diagnostic criteria for occult obstructive hypertrophic cardiomyopathy (OCD). This provides a simple screening for OCD, but this approach focuses on a single indicator and is prone to misdiagnosis or missed diagnosis when faced with diverse individual symptoms. Furthermore, it fails to provide targeted, differentiated assessment and treatment guidelines. Therefore, current technologies lack a multi-dimensional screening system for OCD, resulting in poor reliability in the periodic management of this condition. Summary of the Invention

[0004] To address the aforementioned issues, this invention proposes a grading, reporting, and treatment guidance system for occult obstructive hypertrophic cardiomyopathy. This system enables grading and reporting of occult obstructive hypertrophic cardiomyopathy and provides corresponding treatment guidance for individualized reports, thereby improving the reliability of periodic management of occult obstructive hypertrophic cardiomyopathy.

[0005] To achieve the above objectives, embodiments of the present invention provide a grading, reporting, and treatment guidance system for occult obstructive hypertrophic cardiomyopathy, comprising: a subject screening module, an indicator acquisition module, an indicator grading and reporting module, and a treatment guidance module; the subject screening module is used to screen subject samples that meet preset screening indicators from a pre-acquired number of subject samples to obtain a sample set of subjects to be analyzed; the indicator acquisition module is used to conduct exercise load tests on each subject in the sample set of subjects to be analyzed and monitor several biological indicators of each subject during the load test; the indicator grading and reporting module is used to divide several biological indicators into grading indicators and treatment guidance indicators, and outputs a first indicator grading report if the grading indicator meets a first grading condition, outputs a second indicator grading report if the grading indicator meets a second grading condition, and outputs a third indicator grading report if the grading indicator meets a third grading condition; the treatment guidance module is used to generate corresponding treatment guidance schemes based on the first indicator grading report, the second indicator grading report, or the third indicator grading report, through the treatment guidance indicators.

[0006] This invention proposes a grading, reporting, and treatment guidance system for occult obstructive hypertrophic cardiomyopathy. First, preset screening indicators are used to identify individuals potentially with occult obstructive hypertrophic cardiomyopathy from a sample. Then, exercise stress testing is combined with monitoring the biometrics of each individual, using exercise stress as a key triggering factor as the core monitoring dimension to capture individual differences in symptom presentation under this factor. Next, the biometrics of each individual are categorized, and corresponding grading reports are generated based on these grading indicators. Finally, treatment guidance indicators are combined with the grading reports to generate corresponding treatment guidance plans. This system provides a graded assessment of occult obstructive hypertrophic cardiomyopathy, fully considering individual differences in symptom presentation to generate corresponding treatment guidance plans, effectively improving the reliability of periodic management of occult obstructive hypertrophic cardiomyopathy. Attached Figure Description

[0007] Figure 1 A schematic diagram of the module structure of a grading, reporting, and treatment guidance system for occult obstructive hypertrophic cardiomyopathy provided in a certain embodiment of the present invention; Figure 2 A schematic diagram of the execution flow of a grading, reporting, and treatment guidance system for occult obstructive hypertrophic cardiomyopathy provided in a certain embodiment of the present invention. Figure 1 ; Figure 3 A schematic diagram of the execution flow of a grading, reporting, and treatment guidance system for occult obstructive hypertrophic cardiomyopathy provided in a certain embodiment of the present invention. Figure 2 . Detailed Implementation

[0008] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0009] Example 1 See Figure 1 , Figure 1 This is a schematic diagram of the module structure of a grading, reporting, and treatment guidance system for occult obstructive hypertrophic cardiomyopathy provided in one embodiment of the present invention. Figure 1 As shown in the figure, this invention proposes a grading reporting and treatment guidance system for occult obstructive hypertrophic cardiomyopathy, comprising: a subject screening module 101, an indicator acquisition module 102, an indicator grading report module 103, and a treatment guidance module 104. The subject screening module 101 is used to screen subject samples that meet preset screening indicators from a pre-acquired sample set of subjects, obtaining a sample set of subjects to be analyzed. The indicator acquisition module 102 is used to conduct exercise load tests on each subject in the sample set of subjects to be analyzed, monitoring several biological indicators of each subject during the load test. The indicator grading report module 103 is used to divide the several biological indicators into grading indicators and treatment guidance indicators. If the grading indicator meets a first grading condition, a first indicator grading report is output; if the grading indicator meets a second grading condition, a second indicator grading report is output; if the grading indicator meets a third grading condition, a third indicator grading report is output. The treatment guidance module 104 is used to generate corresponding treatment guidance schemes based on the first indicator grading report, the second indicator grading report, or the third indicator grading report, using the treatment guidance indicators.

[0010] One possible implementation method is described in [link to implementation details]. Figure 2 , Figure 2 A schematic diagram of the execution flow of a grading, reporting, and treatment guidance system for occult obstructive hypertrophic cardiomyopathy provided in a certain embodiment of the present invention. Figure 1 ;like Figure 2As shown, step S1 involves selecting samples from several non-obstructive hypertrophic cardiomyopathy subjects based on the left ventricular outflow tract pressure gradient at rest, thus constructing a sample set for analysis. It should be noted that samples of occult obstructive hypertrophic cardiomyopathy are those already diagnosed with hypertrophic cardiomyopathy, and the preset screening criterion is generally set to a left ventricular outflow tract pressure gradient at rest of less than 30 mmHg. After obtaining the sample set, step S2 involves performing an exercise stress test on each subject in the sample set, combined with exercise stress echocardiography to collect various biometrics. All collected biometrics are used for subsequent grading and treatment guidance analysis. Generally, cardiopulmonary exercise testing (CPET) is used for the exercise stress test. After collecting several biometrics, these biometrics are divided into grading indicators and treatment guidance indicators. Step S3 involves risk stratification based on the grading indicator data. To ensure the reliability of the stratification, risk stratification is performed at each risk level. During risk stratification, the indicator data used are generally those collected from the same exercise stress test. Then, based on the independent data of each indicator, it is determined whether the first, second, or third stratification conditions are met. Finally, all indicators satisfying the stratification conditions are integrated to perform risk stratification. In this embodiment, the risk levels include low, medium, and high risk, and each indicator may satisfy any one of these conditions. This risk stratification is mainly used to classify occult obstructive hypertrophic cardiomyopathy, providing a basis for subsequent treatment guidelines, and is not used for diagnosing occult obstructive hypertrophic cardiomyopathy. After completing the risk stratification, the corresponding indicator stratification report is output. Step S4 is executed, generating corresponding treatment guidelines based on the indicator stratification report. When the output indicator stratification report is low risk, a corresponding level of treatment recommendation is directly generated. When the output indicator stratification report is high or medium risk, further risk stratification is performed based on the treatment guidelines indicators, and further treatment recommendations are generated based on the output indicator stratification report.

[0011] This invention proposes a grading, reporting, and treatment guidance system for occult obstructive hypertrophic cardiomyopathy. First, preset screening indicators are used to identify individuals potentially with occult obstructive hypertrophic cardiomyopathy from a sample. Then, exercise stress testing is combined with monitoring the biometrics of each individual, using exercise stress as a key triggering factor as the core monitoring dimension to capture individual differences in symptom presentation under this factor. Next, the biometrics of each individual are categorized, and corresponding grading reports are generated based on these grading indicators. Finally, treatment guidance indicators are combined with the grading reports to generate corresponding treatment guidance plans. This system provides a graded assessment of occult obstructive hypertrophic cardiomyopathy, fully considering individual differences in symptom presentation to generate corresponding treatment guidance plans, effectively improving the reliability of periodic management of occult obstructive hypertrophic cardiomyopathy.

[0012] Furthermore, the object screening module is used to screen object samples that meet preset screening criteria from a number of pre-acquired object samples to obtain a set of object samples to be analyzed, including: acquiring a number of object samples, collecting the left ventricular outflow tract pressure step difference of each object sample in a resting state; and screening object samples whose left ventricular outflow tract pressure step difference meets preset screening criteria to obtain object samples to be analyzed.

[0013] One preferred implementation method is as follows: Hypertrophic cardiomyopathy (HCM) is characterized by myocardial hypertrophy, with approximately 10%-30% of patients having obstruction with a resting left ventricular outflow tract pressure gradient ≥30 mmHg; while 20%-30% of patients only experience obstruction during exercise or under load, i.e., occult obstructive hypertrophic cardiomyopathy. From a number of non-obstructive hypertrophic cardiomyopathy samples, samples that meet preset screening criteria are selected based on the left ventricular outflow tract pressure gradient at rest for each sample, thus constructing a sample set to be analyzed. Generally, the preset screening criteria are set to a left ventricular outflow tract pressure gradient of less than 30 mmHg at rest.

[0014] By implementing the above scheme and using preset screening indicators, the system can quickly identify individuals with potential hidden obstruction risks from a large number of samples, forming a sample set to be analyzed. This is then combined with the key indicator "left ventricular outflow tract pressure gradient at rest" used in clinical practice for screening, ensuring the scientific validity and operability of the screening. This helps in the subsequent classification of hidden obstructive hypertrophic cardiomyopathy, taking into account individual differences in symptom presentation to generate corresponding treatment guidelines, and improving the reliability of the periodic management of hidden obstructive hypertrophic cardiomyopathy.

[0015] Furthermore, the indicator acquisition module is used to conduct exercise stress tests on each subject in the sample set to be analyzed, and to monitor several biological indicators of each subject during the stress test, including: acquiring symptom-related biological indicators of each subject sample before the exercise stress test; collecting exercise function-related biological indicators of each subject sample during the exercise stress test; and monitoring cardiac structural and functional biological indicators of each subject sample point through echocardiography during the exercise stress test.

[0016] In one preferred implementation method, an exercise stress test is performed on each subject in the sample set to be analyzed, and multiple biomarkers are collected in conjunction with exercise stress echocardiography. All collected indicators are used for subsequent grading and treatment guidance analysis. Generally, the exercise stress test uses cardiopulmonary exercise testing (CPET). Specifically, before performing the exercise stress test, symptom-related biomarkers are obtained through observation, inquiry, and review of the subject's medical history. In this embodiment, the symptom-related biomarkers include: exercise or recovery period symptom indicators and syncope indicators, wherein the exercise or recovery period symptom indicators (angina pectoris and / or dyspnea) are... The syncope index was obtained through observation and questioning of the subjects under analysis. During the exercise stress test, exercise function biometrics were collected in real time using a sphygmomanometer, electrocardiogram (ECG), and calculation of gas metabolism. In this embodiment, these biometrics include: arrhythmia indicators, ECG change indicators, hemodynamic response indicators, and metabolic equivalent indicators. The arrhythmia indicators were obtained from the ECG interface throughout the cardiopulmonary exercise test (CPET) to determine whether complex ventricular arrhythmias were present at rest or during exercise, such as multifocal premature ventricular contractions (PVCs), short runs of ventricular tachycardia, and Ron's syndrome. T / P, etc., are electrocardiogram (ECG) changes obtained from the ECG interface throughout the cardiopulmonary exercise test (CPET) with or without ECG ischemic changes during exercise or recovery. Hemodynamic response indicators are blood pressure values ​​obtained from timed measurements (e.g., every 2 minutes) during the entire CPET test. Metabolic equivalents (METs) are indicators of the body's aerobic and peak exercise capacity obtained from the gas metabolism portion of the CPET test. They are internationally recognized standards for measuring cardiac function and aerobic exercise capacity, and the calculation formula is as follows: Metabolic equivalents (METs) = oxygen uptake per kilogram per minute / 3.5. After the exercise stress test, cardiac ultrasound is used to monitor the heart. In this embodiment, the structural and functional biometrics of the heart include: left ventricular outflow tract pressure gradient (LVOTG), anterior mitral valve leaflet SAM sign, and pulmonary artery systolic blood pressure (PASP). The left ventricular outflow tract pressure gradient is obtained by measuring cardiac ultrasound during cardiopulmonary exercise testing (CPET) combined with exercise stress echocardiography. The anterior mitral valve leaflet SAM sign is obtained by measuring cardiac ultrasound during cardiopulmonary exercise testing (CPET) combined with exercise stress echocardiography. The pulmonary artery systolic blood pressure (PASP) is obtained by measuring cardiac ultrasound during cardiopulmonary exercise testing (CPET) combined with exercise stress echocardiography.

[0017] Implementing the above-mentioned protocol significantly improves the detection capability of occult obstruction through multi-dimensional and dynamic indicator monitoring, preventing missed and false diagnoses of occult obstruction. In addition, collecting indicators throughout the entire process, including before, during, and after exercise stress testing, combined with echocardiography, can comprehensively reflect the patient's physiological changes under stress, capture abnormalities that cannot be detected by static examinations, and accurately record corresponding indicators. This helps in the subsequent classification of occult obstructive hypertrophic cardiomyopathy, considers individual differences in symptom presentation to generate corresponding treatment guidelines, and improves the reliability of the periodic management of occult obstructive hypertrophic cardiomyopathy.

[0018] Furthermore, the indicator grading report module is used to classify several biological indicators into grading indicators and treatment guidance indicators. If a grading indicator meets the first grading condition, a first indicator grading report is output; if it meets the second grading condition, a second indicator grading report is output; and if it meets the third grading condition, a third indicator grading report is output. This includes: classifying the cardiac structural and functional biological indicators, symptom biological indicators, and motor function biological indicators of each sample to be analyzed into grading indicators; classifying the cardiac structural and functional biological indicators of each sample to be analyzed into treatment guidance indicators; and performing the grading process: acquiring the cardiac structural and functional biological indicators, symptom biological indicators, and motor function biological indicators collected during the same exercise stress test; and if all three indicators meet the first grading condition... The system outputs a first-level grading report. If any one of the following biological indicators—cardiac structural-functional, symptom-based, or motor-functional—meets the second-level grading criteria, a second-level grading report is output. If any one of these indicators meets the third-level grading criteria, and none of them meets the second-level grading criteria, a third-level grading report is output, ending the grading process. The cardiac structural-functional biological indicators include: left ventricular outflow tract pressure gradient, mitral anterior leaflet SAM sign, and pulmonary artery systolic pressure. The symptom-based biological indicators include: exercise or recovery period symptom indicators and syncope indicators. The motor-functional biological indicators include: arrhythmia indicators, electrocardiogram changes, hemodynamic response indicators, and metabolic equivalent indicators.

[0019] One preferred implementation method is described in [reference]. Figure 3 , Figure 3 A schematic diagram of the execution flow of a grading, reporting, and treatment guidance system for occult obstructive hypertrophic cardiomyopathy provided in a certain embodiment of the present invention. Figure 2 ,like Figure 3As shown, after collecting several biological indicators, these indicators are divided into grading indicators and treatment guidance indicators. Step S3 is executed, and risk stratification is performed based on the grading indicator data. To ensure the reliability of stratification, the indicator data used in each risk stratification is generally the indicators collected from the same exercise stress test. Then, based on the independent data of each indicator, it is determined whether the first, second, or third grading conditions are met. Finally, the grading conditions met by all indicators are integrated to perform risk stratification. In this embodiment, the risk levels include low risk, medium risk, and high risk. Each indicator may meet any one of these conditions. This risk level is mainly used to grade occult obstructive hypertrophic cardiomyopathy and provide a guidance basis for subsequent treatment guidelines, but it is not used to diagnose occult obstructive hypertrophic cardiomyopathy. Specifically, the cardiac structural and functional biological indicators, symptom biological indicators, and exercise function biological indicators of each sample to be analyzed are divided into grading indicators; the cardiac structural and functional biological indicators of each sample to be analyzed are divided into grading indicators. The indicators are categorized into treatment guidance indicators. For graded indicators, each independent indicator is first assessed for grading conditions. Then, the indicators collected from a single exercise stress test are integrated, and the grading conditions for each indicator are assessed again to generate a corresponding indicator grading report. In this embodiment, when all indicators meet the first grading condition, a first indicator grading report is output. When any one indicator meets the second grading condition, a second indicator grading report is output. When any one indicator meets the third grading condition and none of the second grading conditions are met, a third grading report is output. For example, the first grading condition is used for low-risk stratification, the second grading condition is used for high-risk stratification, and the third grading condition is used for medium-risk stratification. In each risk stratification, all grading indicators must be considered, namely, left ventricular outflow tract pressure gradient indicator, mitral valve anterior leaflet SAM sign indicator, pulmonary artery systolic blood pressure indicator, exercise or recovery period symptom indicator, syncope indicator, arrhythmia indicator, electrocardiogram change indicator, hemodynamic response indicator, and metabolic equivalent indicator.

[0020] By implementing the above scheme, a comprehensive evaluation was conducted using multi-dimensional data collected in the same exercise stress test, ensuring the comprehensiveness and consistency of the classification. Then, the classification logic was used to quickly identify low-risk, medium-risk, and high-risk samples for analysis based on preset classification conditions, reducing subjective judgment errors. This helps in the subsequent classification of occult obstructive hypertrophic cardiomyopathy, taking into account individual differences in symptom presentation to generate corresponding treatment guidelines, thereby improving the reliability of the periodic management of occult obstructive hypertrophic cardiomyopathy.

[0021] Furthermore, if the biological indicators of cardiac structure and function, symptoms, and exercise function all meet the first-level criteria, a first-level indicator report is output, including: if the left ventricular outflow tract pressure gradient is within the preset first-level gradient range, the left ventricular outflow tract pressure gradient indicator meets the first-level criteria; if a mild mitral anterior leaflet SAM sign is present, the mitral anterior leaflet SAM sign indicator meets the first-level criteria; if the pulmonary artery systolic pressure is within the preset first systolic pressure range, the pulmonary artery systolic pressure indicator meets the first-level criteria; if angina and / or dyspnea symptoms are present or absent during a high-intensity exercise stress test, the exercise or recovery period symptom indicator meets the first-level criteria; if there is no history of syncope, the syncope indicator meets the first-level criteria. If there are no complex ventricular arrhythmias, the arrhythmia indicators meet the first-level criteria; if there are or are no ischemic changes after a high-intensity exercise stress test, the electrocardiogram change indicators meet the first-level criteria; if the hemodynamic response is normal, the hemodynamic response indicators meet the first-level criteria; if the metabolic equivalent meets the preset first metabolic range, the metabolic equivalent indicators meet the first-level criteria; if the left ventricular outflow tract pressure gradient, anterior mitral valve SAM sign, pulmonary artery systolic blood pressure, exercise or recovery symptoms, syncope, arrhythmia, electrocardiogram change, hemodynamic response, and metabolic equivalent indicators all meet the first-level criteria, then a first-level indicator report is output, in which the result of the first-level indicator report is low risk.

[0022] In one preferred implementation, when analyzing each indicator independently, if the left ventricular outflow tract pressure gradient is within a preset first gradient interval, the left ventricular outflow tract pressure gradient indicator meets the first grading condition. The preset first gradient interval is characterized by a left ventricular outflow tract pressure gradient greater than or equal to 30 mmHg and less than or equal to 40 mmHg. If mild SAM (Side Aspiration Muscular Atrophy) of the anterior mitral leaflet is present, the anterior mitral leaflet SAM indicator meets the first grading condition. Mild SAM is defined as an anterior mitral leaflet systolic forward motion with a distance greater than 1 cm from the interventricular septum. If pulmonary artery systolic pressure is within a preset first systolic pressure interval, the pulmonary artery systolic pressure indicator meets the first grading condition. The preset first systolic pressure interval is characterized by greater than 30 mmHg and less than 45 mmHg. If angina and / or dyspnea symptoms are present or absent during a high-intensity exercise stress test, the exercise or recovery symptom indicator meets the first grading condition. If there is no history of syncope, the syncope indicator... The following criteria are met: First-level classification; if there are no complex ventricular arrhythmias, the arrhythmia index meets the first-level classification; if there are or no ischemic changes after the high-intensity exercise stress test, the electrocardiogram change index meets the first-level classification; if the hemodynamic response is normal, the hemodynamic response index meets the first-level classification, where poor systolic blood pressure increase or decrease of 10 mmHg or more after exercise is defined as abnormal hemodynamic response; if the metabolic equivalent meets the preset first metabolic interval, the metabolic equivalent index meets the first-level classification, where the preset first metabolic interval is characterized by a metabolic equivalent greater than 5.0; then all indicators are evaluated. If the left ventricular outflow tract pressure gradient index, mitral valve anterior leaflet SAM sign index, pulmonary artery systolic blood pressure index, exercise or recovery period symptom index, syncope index, arrhythmia index, electrocardiogram change index, hemodynamic response index, and metabolic equivalent index all meet the first-level classification criteria, then a first-level classification report is output, i.e., low risk. In this embodiment, the high-intensity exercise stress test is defined as: a peak metabolic equivalent greater than 5.0 obtained through the exercise stress test; By implementing the above protocol, an objective grading report is generated based on objective data such as left ventricular outflow tract pressure gradient, mitral valve anterior leaflet SAM sign, pulmonary artery systolic blood pressure, exercise or recovery symptoms, syncope, arrhythmia, electrocardiogram changes, hemodynamic response, and metabolic equivalent. This avoids subjective judgment errors and is used to grade occult obstructive hypertrophic cardiomyopathy. This provides an accurate data basis for subsequent consideration of individual differences in symptom presentation to generate corresponding treatment guidelines, thereby improving the reliability of cyclical management of occult obstructive hypertrophic cardiomyopathy.

[0023] Furthermore, if the cardiac structural and functional biological indicators, symptom biological indicators, and exercise function biological indicators all meet the second grading criteria, a second indicator grading report is output, including: if the left ventricular outflow tract pressure gradient is within the preset second gradient range, the left ventricular outflow tract pressure gradient indicator meets the second grading criteria; if severe anterior mitral valve SAM sign is present, the anterior mitral valve SAM sign indicator meets the second grading criteria; if pulmonary artery systolic pressure is within the preset second systolic pressure range, the pulmonary artery systolic pressure indicator meets the second grading criteria; if angina and / or dyspnea symptoms occur during a low-intensity exercise stress test, the exercise or recovery period symptom indicator meets the second grading criteria; if there is a history of syncope, the syncope indicator meets the second grading criteria; if there is... For complex ventricular arrhythmias, the arrhythmia indicators meet the second classification criteria; if ischemic changes occur after a low-intensity exercise stress test, the electrocardiogram (ECG) change indicators meet the second classification criteria; if hemodynamic responses are abnormal, the hemodynamic response indicators meet the second classification criteria; if metabolic equivalents meet the preset second metabolic range, the metabolic equivalent indicators meet the second classification criteria; if any one of the following indicators meets the second classification criteria—left ventricular outflow tract pressure gradient, anterior mitral valve SAM sign, pulmonary artery systolic blood pressure, exercise or recovery symptoms, syncope, arrhythmia, ECG changes, hemodynamic response, or metabolic equivalent—is a high-risk ...

[0024] In one preferred implementation, when analyzing each indicator independently, if the left ventricular outflow tract pressure gradient is within a preset second gradient interval, the left ventricular outflow tract pressure gradient indicator meets the second grading condition, wherein the preset second gradient interval is characterized by the left ventricular outflow tract pressure gradient indicator being greater than or equal to 50 mmHg; if severe anterior mitral leaflet SAM sign is present, the anterior mitral leaflet SAM sign indicator meets the second grading condition, wherein severe is defined as the anterior mitral leaflet touching the interventricular septum during systolic anterograde motion; if pulmonary artery systolic pressure is within a preset second systolic pressure interval, the pulmonary artery systolic pressure indicator meets the second grading condition, wherein the preset second systolic pressure interval is characterized by being greater than or equal to 60 mmHg; if angina pectoris and / or dyspnea symptoms occur during a low-intensity exercise stress test, the exercise or recovery period symptom indicator meets the second grading condition; if there is a history of syncope, the syncope indicator meets the second grading condition. If complex ventricular arrhythmias are present, the arrhythmia index meets the second classification criteria; if ischemic changes occur after a low-intensity exercise stress test, the electrocardiogram change index meets the second classification criteria; if hemodynamic responses are abnormal, the hemodynamic response index meets the second classification criteria, where poor systolic blood pressure increase or decrease of 10 mmHg or more after exercise is defined as abnormal hemodynamic response; if the metabolic equivalent meets the preset second metabolic interval, the metabolic equivalent index meets the second classification criteria, where the preset second metabolic interval is characterized by a metabolic equivalent of less than 3.0; if any one of the following indicators meets the second classification criteria: left ventricular outflow tract pressure gradient, mitral valve anterior leaflet SAM sign, pulmonary artery systolic blood pressure, exercise or recovery period symptom indicators, syncope indicators, arrhythmia indicators, electrocardiogram change indicators, hemodynamic response indicators, and metabolic equivalent indicators, a second indicator classification report is output, indicating high risk. In this embodiment, a low-intensity exercise stress test is defined as: a peak metabolic equivalent obtained through an exercise stress test is less than 3.0; By implementing the above protocol, an objective grading report is generated based on objective data such as left ventricular outflow tract pressure gradient, mitral valve anterior leaflet SAM sign, pulmonary artery systolic blood pressure, exercise or recovery symptoms, syncope, arrhythmia, electrocardiogram changes, hemodynamic response, and metabolic equivalent. This avoids subjective judgment errors and is used to grade occult obstructive hypertrophic cardiomyopathy. This provides an accurate data basis for subsequent consideration of individual differences in symptom presentation to generate corresponding treatment guidelines, thereby improving the reliability of cyclical management of occult obstructive hypertrophic cardiomyopathy.

[0025] Furthermore, if any one of the cardiac structural and functional biological indicators, symptom biological indicators, and exercise function biological indicators meets the third-level criteria, and none of these indicators meets the second-level criteria, then a third-level report is output, including: if the left ventricular outflow tract pressure gradient is within the preset third-level interval, then the left ventricular outflow tract pressure gradient indicator meets the third-level criteria; if moderate mitral anterior leaflet SAM sign is present, then the mitral anterior leaflet SAM sign indicator meets the third-level criteria; if pulmonary artery systolic pressure is within the preset third systolic pressure interval, then the pulmonary artery systolic pressure indicator meets the third-level criteria; if angina and / or dyspnea symptoms are present or absent during moderate-intensity exercise stress testing, then the exercise or recovery period symptom indicator meets the third-level criteria; if there is no history of syncope, then the syncope indicator meets the third-level criteria; if there are no complex ventricular arrhythmias, then the arrhythmia indicator meets the third-level criteria. If ischemic changes are present or absent after a moderate-intensity exercise stress test, the ECG change indicators meet the third-level criteria; if the hemodynamic response is normal, the hemodynamic response indicators meet the third-level criteria; if the metabolic equivalent meets the preset third metabolic range, the metabolic equivalent indicators meet the third-level criteria; if any one of the following indicators meets the third-level criteria: left ventricular outflow tract pressure gradient, anterior mitral valve SAM sign, pulmonary artery systolic blood pressure, exercise or recovery symptoms, syncope, arrhythmia, ECG change, hemodynamic response, and metabolic equivalent, and all of these indicators do not meet the second-level criteria, then a third-level grading report is output, in which the result of the third-level grading report is intermediate risk.

[0026] In one preferred implementation, when analyzing each indicator independently, if the left ventricular outflow tract pressure gradient is within a preset third gradient interval, the left ventricular outflow tract pressure gradient indicator meets the third-level criteria. The preset third gradient interval is characterized by a left ventricular outflow tract pressure gradient greater than 40 mmHg and less than 50 mmHg. If moderate mitral anterior leaflet SAM sign is present, the mitral anterior leaflet SAM sign indicator meets the third-level criteria. Moderate mitral anterior leaflet systolic forward motion and interventricular septum distance less than 1 cm are considered moderate. If pulmonary artery systolic pressure is within a preset third systolic pressure interval, the pulmonary artery systolic pressure indicator meets the third-level criteria. The preset third systolic pressure interval is characterized by a systolic forward motion of greater than 45 mmHg and less than 60 mmHg. If angina and / or dyspnea symptoms are present or absent during moderate-intensity exercise stress testing, the exercise or recovery symptom indicator meets the third-level criteria. If there is no history of syncope, the syncope indicator meets the third-level criteria. If there are no complex ventricular arrhythmias, the arrhythmia indicator meets the third-level criteria. The criteria for classification are as follows: If there are or no ischemic changes after a moderate-intensity exercise stress test, the ECG change indicators meet the criteria for classification 3; if the hemodynamic response is normal, the hemodynamic response indicators meet the criteria for classification 3; if the metabolic equivalent meets the preset third metabolic interval, the metabolic equivalent indicators meet the criteria for classification 3, where the preset third metabolic interval is characterized by a metabolic equivalent greater than or equal to 3.0 and less than or equal to 5.0; if any one of the following indicators meets the criteria for classification 3, but none of the following indicators meets the criteria for classification 2, then a classification report for classification 3 is output, i.e., intermediate risk. In this embodiment, a moderate-intensity exercise load test is defined as a peak metabolic equivalent obtained through an exercise load test that is greater than or equal to 3.0 and less than or equal to 5.0. By implementing the above protocol, an objective grading report is generated based on objective data such as left ventricular outflow tract pressure gradient, mitral valve anterior leaflet SAM sign, pulmonary artery systolic blood pressure, exercise or recovery symptoms, syncope, arrhythmia, electrocardiogram changes, hemodynamic response, and metabolic equivalent. This avoids subjective judgment errors and is used to grade occult obstructive hypertrophic cardiomyopathy. This provides an accurate data basis for subsequent consideration of individual differences in symptom presentation to generate corresponding treatment guidelines, thereby improving the reliability of cyclical management of occult obstructive hypertrophic cardiomyopathy.

[0027] Furthermore, the disposal guidance module is used to generate corresponding disposal guidance schemes based on the first indicator classification report, the second indicator classification report, or the third indicator classification report, including: if the first indicator classification report is output, a low-risk disposal guidance scheme is generated; if the second indicator classification report is output, a corresponding disposal guidance scheme is generated based on the disposal guidance indicators; if the third indicator classification report is output, a corresponding disposal guidance scheme is generated based on the disposal guidance indicators.

[0028] One preferred implementation method is described in [reference]. Figure 3 , Figure 3 A schematic diagram of the execution flow of a grading, reporting, and treatment guidance system for occult obstructive hypertrophic cardiomyopathy provided in a certain embodiment of the present invention. Figure 2 ,like Figure 3 As shown, corresponding treatment guidelines are generated based on the indicator classification report. When the output indicator classification report is low-risk, corresponding treatment guidelines are directly generated. When the output indicator classification report is medium-risk or high-risk, further risk stratification is performed based on the treatment guidelines, and further treatment guidelines are generated based on the output indicator classification report. Specifically, when the indicator classification report is low-risk, a low-risk treatment guideline is generated, suggesting moderate-intensity or lower endurance exercise and low-intensity resistance exercise, such as jogging or brisk walking. Treatment recommendations include optimizing medication use, such as beta-blockers, non-dihydropyridine calcium channel blockers, and cardiac myosin inhibitors (CMI). When the output indicator classification report is medium-risk, further risk stratification is required based on the treatment guidelines, and further treatment guidelines are generated based on the output indicator classification report. When the output indicator classification report is high-risk, further risk stratification is also required based on the treatment guidelines, and further treatment guidelines are generated based on the output indicator classification report.

[0029] By implementing the above plan, if the indicator classification report indicates a high-risk result, it will be further classified according to the treatment guidelines to provide a more detailed stratification. This will provide an accurate data basis for generating corresponding treatment guidelines, taking into account individual differences in symptom presentation, and improving the reliability of the cycle management of occult obstructive hypertrophic cardiomyopathy.

[0030] Furthermore, if a second-level indicator report is output, treatment guidance indicators are obtained. These indicators include: left ventricular outflow tract pressure gradient, anterior mitral valve SAM sign, and pulmonary artery systolic blood pressure. If all three indicators meet the first-level criteria, a low-risk treatment guidance plan is generated. If any one of these indicators meets the third-level criteria, but none meets the second-level criteria, a medium-risk treatment guidance plan is generated. If any one of these indicators meets the second-level criteria, a high-risk treatment guidance plan is generated.

[0031] One preferred implementation method is described in [reference]. Figure 3 , Figure 3 A schematic diagram of the execution flow of a grading, reporting, and treatment guidance system for occult obstructive hypertrophic cardiomyopathy provided in a certain embodiment of the present invention. Figure 2 ,like Figure 3 As shown, when the output indicator classification report is high-risk, further risk stratification is required based on the treatment guidance indicators, and further treatment guidance recommendations are generated based on the output indicator classification report. Specifically, the treatment guidance indicators include: left ventricular outflow tract pressure gradient, anterior mitral valve SAM sign, and pulmonary artery systolic blood pressure. When all three indicators meet the first classification criteria, a low-risk treatment guidance plan is generated, which suggests moderate-intensity or lower endurance exercise and low-intensity resistance exercise, such as jogging or brisk walking. The treatment recommendation is to optimize drug use, such as β-blockers, non-dihydropyridine calcium channel blockers, and cardiac myosin inhibitors (CMI). When any one of the three indicators meets the third classification criteria, the risk level is lowered. If the left ventricular outflow tract pressure gradient, the anterior mitral valve SAM sign, and the pulmonary artery systolic blood pressure all fail to meet the criteria for the second stage, a moderate-risk management guideline is generated. This guideline recommends low-to-moderate intensity endurance exercise, such as low-to-moderate intensity walking, and suggests optimizing medication use and, if necessary, performing septal reduction therapy (SRT). If any one of the left ventricular outflow tract pressure gradient, the anterior mitral valve SAM sign, or the pulmonary artery systolic blood pressure meets the criteria for the second stage, a high-risk management guideline is generated. This guideline recommends only low-intensity endurance exercise and suggests optimizing medication use and prioritizing septal reduction therapy (SRT) or cardiac pacing therapy.

[0032] By implementing the above protocol, for results reported as high-risk based on the indicator classification, further classification is performed based on the left ventricular outflow tract pressure gradient, the SAM sign of the anterior mitral valve leaflet, and the pulmonary artery systolic blood pressure to provide a more detailed stratification. This provides an accurate data basis for considering individual differences in symptom presentation and generating corresponding treatment guidelines, thereby improving the reliability of the cycle management of occult obstructive hypertrophic cardiomyopathy.

[0033] Furthermore, if a third-indicator grading report is output, a corresponding treatment guidance plan is generated based on the treatment guidance indicators, including: if a third-indicator grading report is output, the treatment guidance indicators are obtained, wherein the treatment guidance indicators include: left ventricular outflow tract pressure gradient indicator, anterior mitral valve SAM sign indicator, and pulmonary artery systolic blood pressure indicator; if the left ventricular outflow tract pressure gradient indicator, anterior mitral valve SAM sign indicator, and pulmonary artery systolic blood pressure indicator all meet the first-level criteria, a low-risk treatment guidance plan is generated; if any one of the left ventricular outflow tract pressure gradient indicator, anterior mitral valve SAM sign indicator, and pulmonary artery systolic blood pressure indicator meets the third-level criteria, and the left ventricular outflow tract pressure gradient indicator, anterior mitral valve SAM sign indicator, and pulmonary artery systolic blood pressure indicator does not meet the second-level criteria, a medium-risk treatment guidance plan is generated.

[0034] One specific implementation method is described in [reference]. Figure 3 , Figure 3 A schematic diagram of the execution flow of a grading, reporting, and treatment guidance system for occult obstructive hypertrophic cardiomyopathy provided in a certain embodiment of the present invention. Figure 2 ,like Figure 3 As shown, when the output indicator classification report is intermediate risk, further risk stratification is required based on the treatment guidance indicators, and further treatment guidance recommendations are generated based on the output indicator classification report. Specifically, the treatment guidance indicators include: left ventricular outflow tract pressure gradient, mitral valve anterior leaflet SAM sign, and pulmonary artery systolic blood pressure. When the left ventricular outflow tract pressure gradient, mitral valve anterior leaflet SAM sign, and pulmonary artery systolic blood pressure all meet the first classification criteria, a low-risk treatment guidance plan is generated, which provides exercise recommendations such as moderate-intensity or lower endurance exercise and low-intensity resistance exercise, such as jogging or brisk walking. The treatment recommendation is... Optimize medication use, such as beta-blockers, non-dihydropyridine calcium channel blockers, and cardiac myosin inhibitors (CMI). When any one of the left ventricular outflow tract pressure gradient, anterior mitral valve SAM sign, or pulmonary artery systolic blood pressure meets the criteria for the third stage, and none of these criteria meet the criteria for the second stage, a moderate-risk management guideline is generated. This guideline recommends low-to-moderate intensity endurance exercise, such as low-to-moderate intensity walking, and suggests optimized medication use and, if necessary, septal reduction therapy (SRT). Implementing the above protocol, for results reported as intermediate risk based on indicator grading, further grading is performed based on left ventricular outflow tract pressure gradient, mitral valve anterior leaflet SAM sign, and pulmonary artery systolic blood pressure to provide more detailed stratification. This provides an accurate data basis for considering individual differences in symptom presentation and generating corresponding treatment guidelines, thereby improving the reliability of cyclical management of occult obstructive hypertrophic cardiomyopathy.

[0035] Furthermore, the execution of the treatment guidance module, after generating the corresponding treatment guidance plan based on the first indicator grading report, the second indicator grading report, or the third indicator grading report through the treatment guidance indicators, also includes: conducting exercise load tests on each object in the sample set to be analyzed based on a preset time interval, and monitoring several updated biological indicators of each object during the load test; dividing the updated biological indicators into updated grading indicators and updated treatment guidance indicators; if the grading indicator meets the first grading condition, outputting an updated first indicator grading report; if the grading indicator meets the second grading condition, outputting an updated second indicator grading report; and if the grading indicator meets the third grading condition, outputting an updated third indicator grading report; the treatment guidance module is used to generate the corresponding updated treatment guidance plan based on the updated first indicator grading report, the updated second indicator grading report, or the updated third indicator grading report through the updated treatment guidance indicators.

[0036] In one preferred implementation method, the subjects to be analyzed are re-examined every 3-6 months, and step S2 is performed again to collect updated biological indicators. Similarly, steps S3 and S4 are performed to adjust the risk stratification and treatment guidelines based on changes in the indicators. For example, if a subject to be analyzed with a stratification of intermediate risk has their left ventricular outflow tract pressure gradient index drop to less than 40 mmHg and their symptoms are relieved after using the corresponding treatment guidelines, and further analysis reveals that their updated treatment guidelines only meet the first stratification criteria, then the subject to be analyzed is downgraded to low risk, and the treatment guidelines are adjusted to a low-risk treatment guidelines. If a subject to be analyzed has a stratification of low risk, and after using the corresponding treatment guidelines, the left ventricular outflow tract pressure gradient index rises to greater than or equal to 50 mmHg, then the subject to be analyzed is upgraded to high risk, and the treatment guidelines are adjusted to a high-risk treatment guidelines. By implementing the above plan and introducing periodic review, the periodic management of occult obstructive hypertrophic cardiomyopathy will be closed-loop. Furthermore, the grading reports and treatment guidelines can be adjusted according to changes in the indicators of the subjects under analysis, avoiding management failures caused by information lag, enhancing the continuity of monitoring of the subjects under analysis, and improving the reliability of periodic management of occult obstructive hypertrophic cardiomyopathy.

[0037] The above description is only a preferred embodiment of the present invention. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the technical principles of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

[0038] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of this application. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples. Moreover, without contradiction, those skilled in the art can combine and integrate the different embodiments or examples described in this specification, as well as the features of those different embodiments or examples.

[0039] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one of that feature. In the description of this application, "a plurality of" means two or more, unless otherwise explicitly specified.

Claims

1. A grading, reporting, and treatment guidance system for occult obstructive hypertrophic cardiomyopathy, characterized in that, include: The module includes object screening, indicator collection, indicator classification and reporting, and handling guidance. The object filtering module is used to filter object samples that meet preset filtering criteria from a number of pre-acquired object samples to obtain a set of object samples to be analyzed. The indicator acquisition module is used to conduct exercise load tests on each object in the sample set of objects to be analyzed, and to monitor several biological indicators of each object during the load test. The indicator classification report module is used to classify several biological indicators into classification indicators and treatment guidance indicators. If the classification indicator meets the first classification condition, a first indicator classification report is output. If the classification indicator meets the second classification condition, a second indicator classification report is output. If the classification indicator meets the third classification condition, a third indicator classification report is output. The disposal guidance module is used to generate corresponding disposal guidance schemes based on the first indicator classification report, the second indicator classification report, or the third indicator classification report, using the disposal guidance indicators.

2. The grading, reporting, and treatment guidance system for occult obstructive hypertrophic cardiomyopathy as described in claim 1, characterized in that, The object filtering module is used to filter object samples that meet preset filtering criteria from a number of pre-acquired object samples to obtain a set of object samples to be analyzed, including: Several object samples were obtained, and the pressure difference in the left ventricular outflow tract of each object sample under resting conditions was collected. The sample of objects whose pressure step difference in the left ventricular outflow tract meets the preset screening criteria is selected to obtain the sample of objects to be analyzed. The indicator acquisition module is used to conduct exercise load tests on each object in the sample set to be analyzed, and to monitor several biological indicators of each object during the load test, including: Before conducting the exercise stress test, obtain the symptom bioindicators of each sample of subjects to be analyzed; Exercise load tests were conducted on each sample of the object to be analyzed, and the exercise function biometrics of each sample of the object to be analyzed were collected. During the exercise stress test, cardiac structural and functional biometrics of each subject sample point were monitored using echocardiography.

3. The grading, reporting, and treatment guidance system for occult obstructive hypertrophic cardiomyopathy as described in claim 2, characterized in that, The indicator classification report module is used to classify several biological indicators into classification indicators and treatment guidance indicators. If the classification indicator meets a first classification condition, a first indicator classification report is output; if the classification indicator meets a second classification condition, a second indicator classification report is output; and if the classification indicator meets a third classification condition, a third indicator classification report is output, including: The cardiac structural and functional biological indicators, symptom biological indicators, and motor function biological indicators of each sample to be analyzed are classified into graded indicators. The cardiac structural and functional biochemical indicators of each sample to be analyzed are classified as treatment guidance indicators; Perform the grading process: Acquire the cardiac structural and functional bioindicators, the symptom bioindicators, and the exercise function bioindicators collected during the same exercise stress test; If the cardiac structural function biological index, the symptom biological index, and the motor function biological index all meet the first grading condition, then output the first index grading report; If any one of the cardiac structural function biological indicators, the symptom biological indicators, and the motor function biological indicators meets the second grading condition, then the second indicator grading report is output. If any one of the cardiac structural function biological indicators, the symptom biological indicators, and the motor function biological indicators meets the third grading condition, and none of the cardiac structural function biological indicators, the symptom biological indicators, and the motor function biological indicators meet the second grading condition, then the third indicator grading report is output, and the grading process ends. The cardiac structural and functional bioindicators include: left ventricular outflow tract pressure gradient index, mitral valve anterior leaflet SAM sign index, and pulmonary artery systolic pressure index; the symptom-related bioindicators include: exercise or recovery period symptom index and syncope index; the exercise function-related bioindicators include: arrhythmia index, electrocardiogram change index, hemodynamic response index, and metabolic equivalent index.

4. The grading, reporting, and treatment guidance system for occult obstructive hypertrophic cardiomyopathy as described in claim 3, characterized in that, If the cardiac structural function bioindicators, the symptom bioindicators, and the motor function bioindicators all meet the first grading criteria, then a first indicator grading report is output, including: If the pressure gradient of the left ventricular outflow tract is within the preset first gradient range, then the pressure gradient index of the left ventricular outflow tract satisfies the first grading condition. If a mild SAM sign is present in the anterior mitral leaflet, then the SAM sign index of the anterior mitral leaflet meets the first grading condition. If the pulmonary artery systolic pressure is within the preset first systolic pressure range, then the pulmonary artery systolic pressure index meets the first grading condition. If angina pectoris and / or dyspnea symptoms occur with or without during the high-intensity exercise load test, then the exercise or recovery period symptom index meets the first grading criteria. If there is no history of syncope, then the syncope index meets the first grading condition; If there are no complex ventricular arrhythmias, the arrhythmia index meets the first classification criteria. If there are or are no ischemic changes after the high-intensity exercise load test, the electrocardiogram change index meets the first classification condition. If the hemodynamic response is normal, then the hemodynamic response index meets the first grading condition; If the metabolic equivalent meets the preset first metabolic range, then the metabolic equivalent index meets the first classification condition; If the left ventricular outflow tract pressure gradient index, the anterior mitral valve leaflet SAM sign index, the pulmonary artery systolic pressure index, exercise or recovery period symptom index, syncope index, arrhythmia index, electrocardiogram change index, hemodynamic response index, and metabolic equivalent index all meet the first grading conditions, then the first index grading report is output, wherein the result of the first index grading report is low risk.

5. The grading, reporting, and treatment guidance system for occult obstructive hypertrophic cardiomyopathy as described in claim 4, characterized in that, If the cardiac structural function bioindicators, the symptom bioindicators, and the motor function bioindicators all meet the second grading criteria, then a second indicator grading report is output, including: If the pressure gradient of the left ventricular outflow tract is within the preset second gradient range, then the pressure gradient index of the left ventricular outflow tract satisfies the second classification condition. If severe SAM sign of the anterior mitral leaflet is present, then the SAM sign index of the anterior mitral leaflet meets the second classification condition. If the pulmonary artery systolic pressure is within the preset second systolic pressure range, then the pulmonary artery systolic pressure index meets the second classification condition; If angina and / or dyspnea occur during a low-intensity exercise load test, then the exercise or recovery symptom index meets the second grading criteria. If there is a history of syncope, then the syncope index meets the second classification criteria; If complex ventricular arrhythmias are present, the arrhythmia index meets the second classification criteria. If ischemic changes occur after a low-intensity exercise load test, the electrocardiogram change index meets the second classification criteria. If the hemodynamic response is abnormal, then the hemodynamic response index meets the second grading condition; If the metabolic equivalent meets the preset second metabolic range, then the metabolic equivalent index meets the second classification condition; If any one of the following indicators meets the second grading criteria: left ventricular outflow tract pressure gradient, mitral valve anterior leaflet SAM sign, pulmonary artery systolic pressure, exercise or recovery symptoms, syncope, arrhythmia, electrocardiogram changes, hemodynamic response, and metabolic equivalent, a second indicator grading report will be output, wherein the result of the second indicator grading report is high risk.

6. The grading, reporting, and treatment guidance system for occult obstructive hypertrophic cardiomyopathy as described in claim 5, characterized in that, If any one of the cardiac structural function biological indicators, the symptom biological indicators, and the motor function biological indicators meets the third grading condition, and none of the cardiac structural function biological indicators, the symptom biological indicators, and the motor function biological indicators meets the second grading condition, then a third indicator grading report is output, including: If the pressure gradient of the left ventricular outflow tract is within the preset third gradient range, then the pressure gradient index of the left ventricular outflow tract satisfies the third classification condition. If a moderate SAM sign is present in the anterior mitral leaflet, then the SAM sign index in the anterior mitral leaflet meets the third classification criteria. If the pulmonary artery systolic pressure is within the preset third systolic pressure range, then the pulmonary artery systolic pressure index meets the third classification condition. If angina pectoris and / or dyspnea occur during a moderate-intensity exercise load test, then the exercise or recovery symptom index meets the third classification criteria. If there is no history of syncope, then the syncope index meets the third classification criteria; If there are no complex ventricular arrhythmias, then the arrhythmia index meets the third classification criteria. If ischemic changes occur or not after a moderate-intensity exercise load test, the electrocardiogram change index meets the third-level criteria. If the hemodynamic response is normal or there is no obvious abnormality, then the hemodynamic response index meets the third grade condition. If the metabolic equivalent meets the preset third metabolic range, then the metabolic equivalent index meets the third classification condition. If any one of the following indicators—left ventricular outflow tract pressure gradient, anterior mitral valve SAM sign, pulmonary artery systolic blood pressure, exercise or recovery symptoms, syncope, arrhythmia, electrocardiogram changes, hemodynamic response, and metabolic equivalent—meets the third grading criteria, and none of the following indicators meets the second grading criteria, then a third indicator grading report is output, wherein the result of the third indicator grading report is intermediate risk.

7. The grading, reporting, and treatment guidance system for occult obstructive hypertrophic cardiomyopathy as described in claim 6, characterized in that, The handling guidance module is used to generate corresponding handling guidance schemes based on the first indicator classification report, the second indicator classification report, or the third indicator classification report, through the handling guidance indicators, including: If the first indicator classification report is output, a low-risk disposal guidance plan will be generated. If the second indicator classification report is output, a corresponding disposal guidance plan is generated based on the disposal guidance indicators; If the third indicator classification report is output, a corresponding disposal guidance plan is generated based on the disposal guidance indicators.

8. The grading, reporting, and treatment guidance system for occult obstructive hypertrophic cardiomyopathy as described in claim 7, characterized in that, If the second indicator classification report is output, a corresponding disposal guidance plan is generated based on the disposal guidance indicators, including: If the second indicator grading report is output, the treatment guidance indicators are obtained, wherein the treatment guidance indicators include: the left ventricular outflow tract pressure gradient indicator, the anterior mitral valve leaflet SAM sign indicator, and the pulmonary artery systolic pressure indicator; If the left ventricular outflow tract pressure gradient index, the anterior mitral valve leaflet SAM sign index, and the pulmonary artery systolic blood pressure index all meet the first-level criteria, a low-risk treatment guideline is generated. If any one of the left ventricular outflow tract pressure gradient index, the anterior mitral valve SAM sign index, and the pulmonary artery systolic blood pressure index meets the third-level criteria, and none of the left ventricular outflow tract pressure gradient index, the anterior mitral valve SAM sign index, and the pulmonary artery systolic blood pressure index meets the second-level criteria, then a moderate-risk management guideline is generated. If any one of the left ventricular outflow tract pressure gradient index, the anterior mitral valve SAM sign index, and the pulmonary artery systolic blood pressure index meets the second classification criteria, a high-risk management guideline is generated.

9. The grading, reporting, and treatment guidance system for occult obstructive hypertrophic cardiomyopathy as described in claim 7, characterized in that, If the third indicator classification report is output, then a corresponding disposal guidance plan is generated based on the disposal guidance indicators, including: If the third indicator grading report is output, the treatment guidance indicators are obtained, wherein the treatment guidance indicators include: the left ventricular outflow tract pressure gradient indicator, the anterior mitral valve leaflet SAM sign indicator, and the pulmonary artery systolic pressure indicator; If the left ventricular outflow tract pressure gradient index, the anterior mitral valve leaflet SAM sign index, and the pulmonary artery systolic blood pressure index all meet the first-level criteria, a low-risk treatment guideline is generated. If any one of the left ventricular outflow tract pressure gradient index, the anterior mitral valve SAM sign index, and the pulmonary artery systolic blood pressure index meets the third-level criteria, and none of the left ventricular outflow tract pressure gradient index, the anterior mitral valve SAM sign index, and the pulmonary artery systolic blood pressure index meets the second-level criteria, then a moderate-risk management guideline is generated.

10. A grading, reporting, and treatment guidance system for occult obstructive hypertrophic cardiomyopathy as described in any one of claims 1 to 9, characterized in that, After the step of the disposal guidance module generating a corresponding disposal guidance plan based on the first indicator classification report, the second indicator classification report, or the third indicator classification report, the execution of the disposal guidance module further includes: Based on a preset time interval, exercise load tests are conducted on each object in the sample set of objects to be analyzed, and several updated biological indicators of each object are monitored during the load test. The updated biological indicators are divided into updated grading indicators and updated treatment guidance indicators. If the grading indicator meets the first grading condition, an updated first indicator grading report is output. If the grading indicator meets the second grading condition, an updated second indicator grading report is output. If the grading indicator meets the third grading condition, an updated third indicator grading report is output. The disposal guidance module is used to generate corresponding updated disposal guidance schemes based on the updated first indicator classification report, the updated second indicator classification report, or the updated third indicator classification report, through the updated disposal guidance indicators.

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