Anti-carbonylation composition and application

Abstract

The invention belongs to the technical field of skin care, and discloses an anti-carbonylation composition and application thereof.The anti-carbonylation composition comprises an M6P composite solution and an arachnoid cyanotis herb extract, and the mass ratio of the M6P composite solution to the arachnoid cyanotis herb extract is 1: (0.1-19); the M6P composite solution contains 3 to 3.8 weight percent of sodium mannose phosphate and 0.1 to 3 weight percent of mannose. According to the anti-carbonylation composition provided by the invention, the M6P composite solution and the arachnoid cyanotis root extract are compounded according to a specific proportion, so that the inhibition effect of protein carbonylation is effectively improved, and the dark and yellow skin is improved.

Description

Technical Field

[0001] This application relates to the field of skin care technology, specifically to an anti-carbonylation composition and its use. Background Technology

[0002] Among the fourteen major biomarkers of aging, the accumulation of harmful metabolic products from senescent cells is a key phenotype throughout the aging process. These products mainly include misfolded proteins, lipofuscin, and damaged mitochondrial fragments, which are considered "cellular waste." The clearance of these products depends on the autophagy-lysosomal system and metabolic cycles. Once the clearance efficiency declines, it triggers three major chain reactions: first, it occupies cellular space and hinders normal metabolism; second, it releases inflammatory factors and activates chronic inflammation; and third, it damages mitochondrial function, forming a vicious cycle of "metabolic disorder - product accumulation - accelerated aging," ultimately leading to aging phenotypes such as loose skin and organ dysfunction.

[0003] Ultraviolet (UV) radiation from sunlight is one of the main causes of photodamage to the skin. UVA radiation can lead to the accumulation of large amounts of reactive oxygen species (ROS) in the body, causing a series of oxidative damages. This can lead to apoptosis of dermal fibroblasts, degradation of collagen and elastin, and a range of skin problems such as roughness, thickening, wrinkles, age spots, and yellowing. Among these, the yellowing caused by UV radiation originates in the dermis, which is a major target of UVA. UVA-induced ROS can oxidize cell membrane lipids, causing lipid peroxidation and generating lipid peroxides and many aldehydes, such as malondialdehyde (MDA), 4-hydroxy-2-nonenal (4-HNE), and acrolein. These aldehydes can react with lysine, histidine, and cysteine-related groups in proteins to form modified proteins of advanced lipid peroxidation (ALE), namely carbonylated proteins. These form brownish-yellow substances that deposit in the epidermis and upper dermis, leading to decreased skin permeability and a decreased refractive index, resulting in a dull and lackluster appearance. Furthermore, carbonylation leads to the denaturation of fibers such as collagen and elastin, causing the skin to lose elasticity and resulting in sagging, fine lines, and other problems. Carbonylated proteins reduce the stratum corneum's ability to bind water, affecting the function of aquaporins, leading to dry, rough skin and weakening the skin barrier's protective function. Deposited carbonylated proteins are difficult to metabolize, further affecting cell renewal and accelerating skin aging.

[0004] Therefore, in skincare, anti-carbonylation is a crucial topic. While existing technologies have conducted some research on anti-carbonylation, few skincare products specifically target it. There is a need to develop an anti-carbonylation composition to increase the variety of anti-carbonylation skincare products and provide consumers with more skincare options. Summary of the Invention

[0005] One of the objectives of this application is to provide an anti-carbonylation composition that, through a specific ratio of M6P composite solution and pearl dew grass extract, can effectively produce an anti-carbonylation effect, thereby preventing skin problems such as dullness, low elasticity, and dryness.

[0006] Another object of this application is to provide a use of an anti-carbonylation composition, wherein using the anti-carbonylation composition in the preparation of cosmetics can provide the cosmetics with anti-carbonylation effects.

[0007] In addition, this application also provides a cosmetic containing the anti-carbonylation composition of this application, which has an anti-carbonylation effect and can improve dull and yellow skin.

[0008] To achieve the above objective, this application provides an anti-carbonylation composition comprising an M6P complex solution and pearl dew grass extract, wherein the mass ratio of the M6P complex solution to the pearl dew grass extract is 1:0.1-19.

[0009] In the technical solution of this application, the M6P composite solution contains 3-3.8 wt% sodium mannose phosphate and 0.1-3 wt% mannose; as a preferred technical solution, the M6P composite solution of this application is purchased from Beijing Yanzhishan Technology Co., Ltd., and its trade name is M6P(LC).

[0010] Sodium mannose phosphate (LC) in the form of sodium mannose phosphate (M6P) was used in the experiments because salt compounds generally have better water solubility and stability, and are easier to prepare into solutions for experiments.

[0011] When M6P complex solution and pearl dew grass extract are combined in a specific ratio, they can produce a significant effect in improving protein carbonylation.

[0012] Preferably, the concentration of the M6P composite solution in the composition is 0.031-1.1364%.

[0013] Preferably, the concentration of pearl dew grass extract in the composition is 0.0568-1.1875%.

[0014] This application also provides the use of the above-described anti-carbonylation composition in the preparation of cosmetics.

[0015] This application also provides a cosmetic product containing the above-mentioned anti-carbonylation composition.

[0016] The cosmetic product is a cosmetically acceptable dosage form; preferably, the cosmetic product includes creams, lotions, liquids, gels, sprays, or aerosols.

[0017] More preferably, the cosmetic also contains at least one of the following ingredients: moisturizer, thickener, emulsifier, skin moisturizer, preservative, antioxidant, chelating agent, and skin conditioning agent.

[0018] The moisturizer is selected from at least one of the following: glycerin, 1,3-propanediol, butylene glycol, 1,2-pentanediol, 1,2-hexanediol, dipropylene glycol, panthenol, sorbitol, erythritol, sodium hyaluronate, trehalose, allantoin, betaine, β-glucan, ethylhexylglycerin, glyceryl polyether-26, glyceryl glucoside, saccharide isomers, panthioethylamine, aloe polysaccharide, tremella polysaccharide, and dendrobium polysaccharide.

[0019] The thickener is selected from carbomer, xanthan gum, guar gum, locust bean gum, hydroxyethyl cellulose, sodium carboxymethyl cellulose, acrylate cross-linking polymer-2 sodium, acrylate / C10-30 alkanol acrylate cross-linking polymer, and polyacrylate cross-linking polymer-6;

[0020] The emulsifiers are selected from glyceryl stearate, sorbitan stearate, hydrogenated lecithin, cetearyl glucoside, cetyl phosphate potassium, polysorbate-60, C12-20 alkyl glucoside, lauryl glucoside, polysorbate-20, polysorbate-80, polyglycerol-3 diisostearate, polyglycerol-3 methylglucose distearate, polyglycerol-10 laurate, methylglucose sesquistearate, PEG-100 stearate, sorbitan laurate, sorbitan olive oil ester, cetearyl olive oil ester, cetearyl alcohol polyether-20, sodium stearoyl glutamate, and PPG-6-decyltetradecyl alcohol polyether-30.

[0021] The emollients mentioned are selected from white oil, petrolatum, microcrystalline wax, dioctyl carbonate, isononyl isononanoate, ethylhexyl palmitate, isooctyl palmitate, caprylic / capric triglyceride, hydrogenated polyisobutylene, hydrogenated polydecene, isohexadecane, C12-15 benzoyl alcohol, polydimethylsiloxane, polydimethylsiloxane alcohol, cetearyl alcohol, beeswax, lanolin, shea butter, squalane, phytosphingosine, ceramide AP, ceramide NP, ceramide EOP, olive oil, coconut oil, avocado oil, jojoba oil, jojoba esters, grape seed oil, moringa seed oil, sunflower seed oil, meadowfoam seed oil, low erucic acid rapeseed oil, macadamia nut seed oil, argan kernel oil, sweet almond oil, sweet almond oil, wild soybean oil, murine palm fruit oil, evening primrose oil, walnut oil, rice bran oil;

[0022] The preservatives mentioned are selected from chlorphenesin, phenoxyethanol, DMDM ​​hydantoin, benzoic acid and its salts and esters, propionic acid and its salts, salicylic acid and its salts, and sorbic acid and its salts;

[0023] The antioxidants mentioned are selected from tocopherol, tocopherol acetate, tocopherol succinate, p-hydroxyacetophenone, butylated hydroxytoluene, pentaerythritol tetra(bis-tert-butylhydroxyhydrocinnamic acid) ester, sodium gluconate, copper gluconate, ergothioneine, thiotaurine, hydroxypropyl tetrahydropyranotriol, and ethyl bisiminomethyl guaiacol manganese chloride.

[0024] The chelating agent is selected from disodium EDTA, octanoyl hydroxamic acid, and potassium gluconate;

[0025] The skin conditioning agent is selected from niacinamide, arbutin, tranexamic acid, ferulic acid, diglucosyl gallic acid, ascorbic acid, sodium ascorbate phosphate, ascorbate glucoside, ascorbate tetraisopalmitate, 3-o-ethyl ascorbic acid, phenylethyl resorcinol, tetrahydromethylpyrimidine carboxylic acid, undecanoyl phenylalanine, bisabolol, ethanoyl alcohol, adenosine, carnosine, glutathione, dipotassium glycyrrhizate, ammonium glycyrrhizate, glycyrrhizin, glycyrrhizin extract, glycyrrhizin, glycyrrhiza glabra extract, asiaticoside, hydroxyasiaticoside, asiaticus extract, yarrow extract, ginger root extract, ginseng root extract, lemon fruit extract, watermelon fruit extract, pearl extract, sea fennel extract, white water lily extract, kelp extract, lactobacillus fermentation product, pseudoalteromonas fermentation product extract, milk thistle fruit extract, apple fruit extract, palmate kelp extract, and barley seed extract.

[0026] Beneficial effects:

[0027] Compared with the prior art, this application provides an anti-carbonylation composition, which effectively enhances the inhibition of protein carbonylation by combining M6P composite solution and pearl dew grass extract in a specific ratio, and can improve dull and yellow skin. Detailed Implementation

[0028] The present application will be further described below with reference to embodiments, but this does not constitute any limitation on the present application. Any limited modifications made within the scope of the claims of the present application shall still be within the scope of the claims of the present application.

[0029] To illustrate the technical content of this application in detail, the following description is provided in conjunction with the embodiments.

[0030] In the following examples and comparative examples, the M6P composite solution was purchased from Beijing Yanzhishan Technology Co., Ltd., trade name M6P(LC), containing 3-3.8% sodium mannose phosphate, 0.1-3% mannose, 40-60% glycerol, and 33.2-56.9% water; the pearl dew grass extract was purchased from Shanghai Jiayu Biotechnology Co., Ltd.

[0031] Examples and Comparative Examples

[0032] Prepare the composition according to the formulation table in Table 1. The preparation method is to stir and mix at room temperature. It should be noted that the water in the formulation table is used as a solvent for dilution concentration and is not an active ingredient. Those skilled in the art can make conventional adjustments and substitutions according to actual needs.

[0033] Unless otherwise specified, all parts are by weight and all percentages are by weight percentage.

[0034] It should be noted that the M6P composite solution and pearl dew grass extract used in the embodiments and comparative examples of this application are all from the same batch of raw materials, and their composition is consistent.

[0035] Table 1 Formulation of Examples and Comparative Examples

[0036] Total concentration (%) Mass ratio of M6P complex solution to pearl dew grass extract M6P composite solution (%) Pearl dew grass extract (%) Example 1 1.25 1:0.1 1.1364 0.1136 Example 2 1.25 1:0.25 1 0.25 Example 3 1.25 1:4 0.25 1 Example 4 1.25 1:9 0.125 1.125 Example 5 1.25 1:19 0.0625 1.1875 Comparative Example 1 1.25 1:0 1.25 / Comparative Example 2 1.25 0:1 / 1.25 Comparative Example 3 1.25 1:0.04 1.2 0.05 Comparative Example 4 1.25 1:20 0.0595 1.1905 Comparative Example 5 1.25 1:24 0.05 1.2 Example 6 0.625 1:0.1 0.5682 0.0568 Example 7 0.625 1:0.25 0.5000 0.0568 Example 8 0.625 1:4 0.125 0.5 Example 9 0.625 1:9 0.0625 0.5625 Example 10 0.625 1:19 0.031 0.594 Comparative Example 6 0.625 1:0 0.625 / Comparative Example 7 0.625 0:1 / 0.625 Comparative Example 8 0.625 1:0.04 0.6 0.025 Comparative Example 9 0.625 1:20 0.0298 0.5952

[0037] Efficacy testing

[0038] Cellular Experiment: Determination of Anti-Carbonylation Activity of Human Dermal Fibroblasts in In Vitro

[0039] Cell line: Human dermal fibroblasts.

[0040] Cell passage number: at least 2 passages.

[0041] Cell quantity per experimental group: 5 × 10⁶ 4 One hole / hole.

[0042] Experimental steps:

[0043] 1. Seed cells in 12-well plates (5 × 10⁶ cells / well). 4 (each well) was incubated at 37°C with 5% CO2 for 24 hours.

[0044] 2. After incubation, remove the culture medium, gently rinse the cells once or twice with D-Hanks, add 1 mL of D-Hanks to each well, and then expose the model control group and sample group to UVA 9 J / cm. 2 Radiation was applied, while the normal control group was placed in the dark.

[0045] 3. After modeling, the normal control group and the model control group were replaced with fresh culture medium, and the sample group was replaced with fresh culture medium containing the concentrations of the examples and comparative examples (such as in Example 1, the fresh culture medium contained 1.1364% M6P complex solution and 0.1136% pearl dew grass extract). The biological replicates were repeated 3 times and incubated at 37°C and 5% CO2 for 24 hours.

[0046] 4. After incubation, carbonylated proteins were labeled using FTSC fluorescent probes, and the fluorescence intensity was analyzed. The inhibition rate, i.e., the anti-carbonylation effect, was calculated based on the fluorescence intensity.

[0047] .

[0048] The examples and comparative examples were tested according to the above method, and the results are shown in Table 2. Statistical analysis was performed using the independent samples t-test between the two groups. The statistical results were considered statistically significant with α=0.05 as the test limit, and p<0.05 (compared to the model control group) was considered statistically significant. Compared with the model control group, the average intensity of carbonylated proteins in the sample group was significantly reduced, indicating that the sample has an anti-carbonylation effect.

[0049] To illustrate the additive effect of this composition, the King's law was used for verification:

[0050] Q = E (a+b) / (E) a ×q a +E b ×q b -E a ×q a ×E b ×q b / 100);

[0051] Where a is the M6P complex solution, b is pearl dew grass extract; E is the corresponding inhibition rate (e.g., Ea is the inhibition rate of the M6P complex solution), and q is the corresponding concentration ratio (e.g., qa=1 / 1.01=0.9901 in Example 1).

[0052] The results are shown in Table 3. Q < 0.85 indicates antagonism, Q = 0.85 - 1.15 indicates addition, and Q > 1.15 indicates synergistic enhancement.

[0053] Table 2. Results of carbonylation resistance in Examples 1-10 and Comparative Examples 1-9

[0054] Experimental Groups Mean fluorescence intensity of carbonylated proteins Inhibition rate % p-value (vs. model control group) normal control group 8.56 / <0.001 Model control group 32.8 / / Example 1 10.53 67.90% <0.001 Example 2 9.29 71.68% <0.001 Example 3 10.21 68.87% <0.001 Example 4 11.14 66.04% <0.001 Example 5 11.69 64.36% <0.001 Comparative Example 1 15.9 51.52% <0.01 Comparative Example 2 17.3 47.26% <0.01 Comparative Example 3 16.2 50.61% <0.01 Comparative Example 4 17.2 47.56% <0.01 Comparative Example 5 17.6 46.34% <0.01 Example 6 17.9 45.43% <0.01 Example 7 16.5 49.70% <0.001 Example 8 16.8 48.78% <0.001 Example 9 17.9 45.43% <0.001 Example 10 18.2 44.51% <0.001 Comparative Example 6 20.3 38.11% <0.01 Comparative Example 7 22.1 32.62% <0.01 Comparative Example 8 19.4 40.85% <0.01 Comparative Example 9 20.6 37.20% <0.01

[0055] Table 3. Combined synergistic results of Examples 1-8 and Comparative Examples 1-9

[0056] Experimental Groups E(a+b) Ea qa Eb qb Q value Collaboration Example 1 67.90% 51.52% 0.9091 47.26% 0.0909 1.33 Enhanced collaboration Example 2 71.68% 51.52% 0.8000 47.26% 0.2000 1.41 Enhanced collaboration Example 3 68.87% 51.52% 0.2000 47.26% 0.8000 1.43 Enhanced collaboration Example 4 66.04% 51.52% 0.1000 47.26% 0.9000 1.38 Enhanced collaboration Example 5 64.36% 51.52% 0.0500 47.26% 0.9500 1.36 Enhanced collaboration Comparative Example 1 51.52% 51.52% / / / / single Comparative Example 2 47.26% / / 47.26% / / single Comparative Example 3 50.61% 51.52% 0.9600 47.26% 0.0400 0.99 Add Comparative Example 4 47.56% 51.52% 0.0476 47.26% 0.9524 1.00 Add Comparative Example 5 46.34% 51.52% 0.0400 47.26% 0.9600 0.98 Add Example 6 45.43% 38.11% 0.9091 32.62% 0.0909 1.21 Enhanced collaboration Example 7 49.70% 38.11% 0.8980 32.62% 0.1020 1.32 Enhanced collaboration Example 8 48.78% 38.11% 0.2000 32.62% 0.8000 1.45 Enhanced collaboration Example 9 45.43% 38.11% 0.1000 32.62% 0.9000 1.37 Enhanced collaboration Example 10 44.51% 38.11% 0.0496 32.62% 0.9504 1.35 Enhanced collaboration Comparative Example 6 38.11% 38.11% / / / / single Comparative Example 7 32.62% / / 32.62% / / single Comparative Example 8 40.85% 38.11% 0.9600 32.62% 0.0400 1.08 Add Comparative Example 9 37.20% 38.11% 0.0476 32.62% 0.9524 1.13 Add

[0057] According to the results in Tables 2 and 3:

[0058] According to the data from Examples 1-10, this application, by combining M6P composite solution and pearl dew grass extract in a reasonable ratio, can produce a good synergistic enhancement effect on anti-carbonylation, and its inhibition rate is close to that of the normal control group.

[0059] Based on the comparison of data from Examples 1-5 and Comparative Examples 1-5, and the comparison of data from Examples 6-10 and Comparative Examples 6-9, it can be seen that the present application produced a significant synergistic enhancement effect by combining M6P composite solution and pearl dew grass extract, which can synergistically improve the anti-carbonylation effect of the composition; even the low concentrations of Examples 7 and 8 produced a significantly improved anti-carbonylation effect compared with the high concentration of pearl dew grass extract in Comparative Example 2.

[0060] The comparison between Examples 1-5 and Examples 6-10 shows that, under the same ratio, increasing the concentration of M6P composite solution and pearl dew grass extract also improves the anti-carbonylation effect of the composition, but the degree of improvement varies. It is speculated that this may be related to the synergistic effect produced by the ratio of M6P composite solution and pearl dew grass extract.

[0061] To verify the above speculation, this application found through mutual comparison between Examples 1-5 and Examples 6-10 that, when the total concentration of M6P composite solution and pearl dew grass extract is the same, the ratio of M6P composite solution to pearl dew grass extract does have a certain impact on the inhibition rate of the composition. Moreover, it is not the case that the higher the proportion of M6P composite solution, the higher the inhibition rate of the composition. The optimal ratio of M6P composite solution to pearl dew grass extract for synergistic enhancement is 1:0.25, followed by 1:4, and then 1:0.1, 1:9 and 1:19 respectively.

[0062] A comparison of the data from Examples 1-5 and Comparative Examples 3-5 shows that when the ratio of M6P composite solution to pearl dew grass extract is outside the scope of this application, the anti-carbonylation effect of the composition decreases significantly. It is speculated that only a specific ratio of M6P composite solution and pearl dew grass extract can exert a significant synergistic enhancement effect. However, when the ratio exceeds the scope of this application, a comparison of the data from Comparative Examples 3-5 and Comparative Examples 8 and 9 shows that only a weak additive effect can be produced.

[0063] Based on the comparison of data from Examples 1-5 and Comparative Examples 3-5, Examples 6-9 and Comparative Examples 8-9, and the comparison of data from Comparative Examples 1-2 and Comparative Example 6, it can be seen that if the ratio of M6P composite solution and pearl dew grass extract is not within the scope of the technical solution of this application, the composition cannot exert the synergistic enhancement effect between the components. As a result, the compositions of Comparative Examples 3-5 are not as effective as those of Comparative Example 1 using only M6P composite solution, and the compositions of Comparative Example 9 are not as effective as those of Comparative Example 6 using only M6P composite solution.

[0064] Application Example 1: A face cream containing an anti-carbonylation composition

[0065] (1) Weighing the sample:

[0066] Weigh out the following ingredients by weight percentage: 5% glycerol, 0.05% disodium EDTA, 2% cetearyl oleate, 2% sorbitan oleate, 3% behenyl alcohol, 5% caprylic / capric triglyceride, 3% polydimethylsiloxane, 1% tocopheryl acetate, 0.5% p-hydroxyacetophenone, 3% 1,3-propanediol, 1% 1,2-pentanediol, 1% 1,2-hexanediol, 1.25% anti-carbonylation composition (Example 2), and the balance water.

[0067] Material A is prepared by mixing water, glycerol, and disodium EDTA.

[0068] Cetearyl oleic acid, sorbitan oleic acid ester, behenyl alcohol, caprylic / capric triglyceride, and polydimethyl ether.

[0069] Material B is prepared by mixing basic siloxane and tocopherol acetate;

[0070] Material C is prepared by mixing p-hydroxyacetophenone, 1,3-propanediol, 1,2-pentanediol, and 1,2-hexanediol.

[0071] (2) Preparation method of face cream:

[0072] S1: Add material A into the production cylinder, homogenize at 2500r / min for 15min, stir, and the temperature of the production cylinder is 84℃.

[0073] S2: Add material B to the oil phase pot and stir. The temperature of the oil phase pot is 84℃.

[0074] S3: Add material B obtained in step S2 into the production cylinder and homogenize it under vacuum at 2500 r / min.

[0075] After 15 minutes, the temperature was maintained at 84℃ for 20 minutes, and then the temperature was lowered to 43℃ to obtain material D.

[0076] S4: Add material C and the anti-carbonylation composition to material D and mix to obtain the finished face cream A.

[0077] (3) In step (1), 1.25% of the anti-carbonylation composition of Example 2 was replaced with 1.25% of the M6P complex solution (LC) of Comparative Example 2 to obtain face cream B; 1.25% of the anti-carbonylation composition of Example 2 in step (1) was replaced with 1.25% of pearl dew grass extract of Comparative Example 4 to obtain face cream C; 1.25% of the anti-carbonylation composition of Example 2 in step (1) was replaced with 1.2% of the M6P complex solution and 0.05% of the pearl dew grass extract of Comparative Example 6 to obtain face cream D; 1.25% of the anti-carbonylation composition of Example 2 in step (1) was replaced with 1.2% of the M6P complex solution and 0.05% of the pearl dew grass extract of Comparative Example 7 to obtain face cream E.

[0078] Human efficacy evaluation trial

[0079] Participants: 60 participants, aged 30-45 years, with a mean age of 38.6 years. Participants had no serious chronic wasting diseases (asthma, diabetes, etc.); had not used hormonal drugs, anti-inflammatory drugs, or immunosuppressants in the past month; and had not used any products or medications that affect skin color, such as glycolic acid or salicylic acid, in the past two months. During the trial, participants were instructed not to consume large amounts of foods that affect skin yellowing, such as carrots and oranges.

[0080] Test Procedure: Subjects were randomly divided into 4 groups. After facial cleansing, they sat quietly for 30 minutes in a constant temperature and humidity environment (temperature 20℃~22℃, relative humidity 40%RH~60%RH). Facial skin data was collected, and the b* value was measured using a skin color test probe (Colorimeter CL400) (the higher the b* value, the more yellow the skin tone). The 5 groups of subjects used face creams A, B, C, D, and E respectively, and were followed up after 28 days of continuous application. The test results are shown in Table 4.

[0081] Statistical analysis was performed using the independent samples t-test between the two groups. The statistical results were considered statistically significant with α=0.05 as the test limit and p<0.05 (group comparison) as the statistical significance level. Compared with the model control group, the average intensity of carbonylated proteins in the sample group was significantly reduced, indicating that the sample has an anti-carbonylation effect.

[0082] Table 4. Results of Skin Color b* Value Test

[0083]

[0084] As shown in Table 4, after 28 days of use, face cream A (a cosmetic containing the anti-carbonylation composition of Example 2) exhibited an anti-carbonylation effect, significantly improving dull and yellowish skin. A comparison of the data from Example 2 with those from Comparative Examples 1-4 shows that the cosmetic containing the anti-carbonylation composition of Example 2 significantly improved the effect of improving yellowish skin compared to cosmetics containing only M6P complex solution, only pearl dew grass extract, or compositions exceeding the proportion range of this technical solution.

[0085] The technical solution of this application can effectively improve the skin condition of the subjects.

[0086] The embodiments presented herein are merely selected implementations based on combinations of all possible embodiments. The appended claims should not be limited to the embodiments described herein. Some numerical ranges used in the claims include sub-ranges within them, and variations within these ranges should also be covered by the appended claims.

Claims

1. A composition resistant to carbonylation, characterized in that, The composition comprises M6P complex solution and pearl water grass extract, the mass ratio of the M6P complex solution and the pearl water grass extract is 1:0.1-19; the M6P complex solution contains 3-3.8wt% sodium mannose phosphate and 0.1-3wt% mannose.

2. The anti-carbonylation composition of claim 1, wherein, The concentration of the M6P complex solution in the composition is 0.031-1.1364%.

3. The anti-carbonylation composition of claim 1, wherein, The concentration of the pearl water grass extract in the composition is 0.0568-1.1875%.

4. Use of the anti-carbonylation composition according to any one of claims 1-3 in the preparation of a cosmetic product.

5. Use according to claim 4, characterized in that, The cosmetic product contains the composition according to any one of claims 1-3.

6. The cosmetic product according to claim 5, characterized in that, The cosmetic product is in a cosmetically acceptable dosage form, including cream, liquid, gel, spray or aerosol.

7. The cosmetic product according to claim 6, characterized in that, It further contains at least one of the following raw materials: humectant, thickening agent, emulsifier, emollient, preservative, antioxidant, chelating agent, skin conditioning agent.

8. The cosmetic product according to claim 7, characterized in that, The humectant is selected from at least one of glycerin, 1,3-propanediol, butylene glycol, 1,2-pentanediol, 1,2-hexanediol, dipropylene glycol, panthenol, sorbitol, erythritol, sodium hyaluronate, trehalose, allantoin, betaine, beta-glucan, ethylhexylglycerin, glycereth-26, glyceryl glucoside, sugar isomer, pantethine, aloe polysaccharide, tremella polysaccharide, dendrobium polysaccharide; The thickening agent is selected from carbomer, xanthan gum, guar gum, locust bean gum, hydroxyethyl cellulose, sodium carboxymethyl cellulose, sodium acrylate cross-linked polymer-2, acrylate / C10-30 alkanol acrylate cross-linked polymer, polyacrylate cross-linked polymer-6; The emulsifier is selected from glyceryl stearate, sorbitan stearate, hydrogenated lecithin, cetearyl glucoside, potassium cetyl phosphate, polysorbate-60, C12-20 alkyl glucoside, lauryl glucoside, polysorbate-20, polysorbate-80, polyglyceryl-3 diisostearate, polyglyceryl-3 methylglucose distearate, polyglyceryl-10 laurate, methyl glucose sesquistearate, PEG-100 stearate, sorbitan laurate, sorbitan olivate, cetearyl olivate, cetearyl peg-ppg-20, sodium stearoyl glutamate, PPG-6-decyltetradecin polyether-30; The emollients are selected from the group consisting of white petrolatum, petrolatum, microcrystalline wax, dicaprylyl carbonate, isononyl isononanoate, ethylhexyl palmitate, isooctyl palmitate, caprylic / capric triglyceride, hydrogenated polyisobutene, hydrogenated polydecene, isohexadecane, C12-15 alkyl benzoate, dimethicone, dimethiconol, cetearyl alcohol, beeswax, lanolin, shea fruit butter, squalane, phytosphingosine, ceramide AP, ceramide NP, ceramide EOP, olive oil, coconut oil, avocado oil, jojoba oil, jojoba esters, grape seed oil, mongongo nut oil, sunflower seed oil, white lupine seed oil, canola oil, aniseed oil, macadamia integrifolia seed oil, argan oil, sweet almond oil, sweet peach kernel oil, wild soybean oil, muru-muru butter, evening primrose oil, illipe butter, rice bran oil; The preservatives are selected from the group consisting of chlorphenesin, phenoxyethanol, DMDM hydantoin, benzoic acid and its salts and esters, propionic acid and its salts, salicylic acid and its salts, sorbic acid and its salts; The antioxidants are selected from the group consisting of tocopherol, tocopherol acetate, tocopherol succinate, para-hydroxyacetophenone, butylated hydroxytoluene, pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate, sodium gluconate, copper gluconate, ergothioneine, taurine, hydroxypropyl tetrahydro pyrantriol, ethyl bisiminiummethylveratrum manganese chloride; The chelating agents are selected from the group consisting of disodium EDTA, caprylyl glycol, potassium gluconate; The skin conditioning agents are selected from the group consisting of niacinamide, arbutin, tranexamic acid, ferulic acid, digalloyl resorcinol, ascorbic acid, sodium ascorbyl phosphate, ascorbyl glucoside, ascorbyl tetraisopalmitate, 3-o-ethyl ascorbic acid, benzylether resorcinol, tetrahydro methy pyrimidine carboxylic acid, undecylenoyl phenylalanine, bisabalol, farnesol, adenosine, carnosine, glutathione, dipotassium glycyrrhizate, ammonium glycyrrhizate, glycyrrhiza extract, glabridin, licorice extract, asiaticoside, madecassoside, asiatic acid, madecassic acid, centella asiatica extract, achyranthes bidentata extract, arctium lappa extract, aloe barbadensis leaf extract, avena sativa extract, chondrus crispus extract, lactobacillus ferment, pseudomonas ferment extract, silybum marianum fruit extract, malus domestica fruit extract, palmophyllum palmiforme extract, hordeum vulgare seed extract.

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