Water-soluble phenylspirocyclohexane compounds and pharmaceutical compositions thereof

CN121609707BActive Publication Date: 2026-08-28ANHUI IPCKE PHARMACEUTICAL TECHNOLOGY DEVELOPMENT CO LTD
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Patent Information

Application Number
CN202511843452.0
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-12-09
Publication Date
2026-08-28
Estimated Expiration
2045-12-09

AI Technical Summary

Technical Problem

但是，这些出版物中没有一篇讲授使用何种方法产生本文中发明的具体前药

Benefits of technology

[0047]2）本发明的化合物或其盐，使得活性成分cebranopadol的产生变得容易；

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Abstract

The present application relates to the field of pharmaceutical chemistry, and provides a new phenyl spirocyclohexane compound and a pharmaceutical composition thereof, specifically, on the basis of Cebranopadol, a compound of formula I and a pharmaceutically acceptable salt thereof with excellent water solubility and stability, which can be used for preparing a medicine for treating pain.
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Citation Information

Patent Citations

  • A compound, and a method of preparing and using the same

    CN121471228B

  • Composition comprising cebranopadol in a dissolved form

    EP3253374A1

  • Spirocyclic cyclohexane derivatives

    WO2004043967A1

  • MIXED ORL 1 / µ AGONISTS FOR TREATING PAIN

    WO2008040481A1

  • Pharmaceutical dosage form comprising 6'-fluoro-(n-methyl- or n,n-dimethyl-)-4-phenyl-4',9'-dihydro-3'h-spiro[cylohexane-1,1'-pyrano[3,4,b]indol]-4-amine

    WO2012016695A2