Integrated nursing device for eliminating thrombus in PICC (Peripherally Inserted Central Catheter) by ultrasonic waves

Abstract

The invention relates to an integrated nursing device for eliminating thrombus in a PICC (Peripherally Inserted Central Catheter) by ultrasonic waves, which belongs to the technical field of medical instruments and comprises a handheld host and a disposable treatment head. A venturi negative pressure generating unit and a flushing fluid power unit are integrated in the handheld host. The disposable treatment head comprises a multi-section flexible connection structure capable of self-adapting to bending of the catheter, a miniature ultrasonic suppository breaking unit capable of achieving cross interference focusing based on a single crystal wafer and a reflection cavity, and a multi-layer coaxial cavity structure capable of achieving synchronous suction and flushing. When the device works, ultrasonic energy directly acts on thrombus in a catheter to efficiently crush the thrombus, meanwhile, fragments are removed in time through negative pressure generated by the Venturi effect, and visual state indication is provided through the mechanical feedback unit. The problems that a traditional method is low in efficiency, complex in operation and asynchronous in fragment removal are solved, and safe, efficient and convenient integrated catheter thrombus removal is achieved.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, specifically to an integrated nursing device for eliminating thrombi in PICC catheters using ultrasound. Background Technology

[0002] Peripherally inserted central catheters (PICCs) provide a safe and reliable vascular access for patients requiring medium- to long-term intravenous infusion, chemotherapy, or parenteral nutrition support, and are widely used in clinical practice. However, catheter-related complications remain a key challenge affecting their long-term safe use, with in-catheter thrombosis being one of the most common and difficult-to-manage complications. Thrombosis can lead to partial or complete catheter occlusion, causing treatment interruption and difficulty in drug infusion; more seriously, the thrombus may spread along the catheter wall or detach, potentially inducing life-threatening consequences such as deep vein thrombosis and pulmonary embolism, while also significantly increasing the risk of catheter-related bloodstream infections.

[0003] Currently, the routine methods for treating PICC catheter-related thrombosis in clinical practice mainly include thrombolysis, physical recanalization, and catheter replacement. Thrombolysis typically involves instilling thrombolytic drugs such as urokinase and tissue plasminogen activator into the catheter. This method has significant limitations: for older thrombi that have been formed for a long time, drug penetration is difficult, thrombolysis efficiency is low, and the drug often needs to be retained for a long time, making the process lengthy; at the same time, the use of systemic thrombolytic drugs carries the risk of bleeding, and some patients may experience drug allergies or drug resistance. When thrombolysis fails, attempts are often made to use a syringe for negative pressure aspiration or a guidewire for mechanical recanalization. These procedures are highly dependent on the experience and intuition of nursing staff, and are essentially blind explorations, making it impossible to determine in real time whether the thrombus has been effectively removed or merely moved, resulting in unstable success rates and the potential risk of pushing the thrombus deeper or causing damage to the vascular intima. Ultimately, if all the above methods fail, it is necessary to remove the original catheter and reinsert it on the opposite side, which not only causes secondary trauma and pain to the patient but also increases medical costs and vascular resource consumption. In search of a more direct and effective physical solution, ultrasound technology has been explored for the treatment of thrombosis. Current ultrasound thrombolysis devices are primarily external, with the treatment head applied to the patient's skin and tissues to deliver ultrasound energy to deep blood vessels. However, for microthrombi formed within PICC catheters, this method suffers significant energy attenuation during transmission, making it difficult to create an effective therapeutic sound field within the catheter lumen, resulting in low efficiency and potential unnecessary thermal effects on surrounding healthy tissues. Miniaturizing the ultrasound probe and placing it directly inside the catheter presents a near-insurmountable technical obstacle: the PICC catheter lumen is extremely small (typically between 0.5 and 1.2 mm in diameter). At this scale, traditional miniature ultrasound probes used for intravascular imaging can only perform diagnostic functions, and their generated sound energy density is far insufficient to break up thrombi. Furthermore, integrating a transducer with therapeutic energy output and the multi-cavity structure necessary for flushing and aspiration would result in an overall size far exceeding the catheter's inner diameter, making it practically impossible. Therefore, achieving a breakthrough between "functional completeness" and "miniaturization" has long been a technical bottleneck that remains unresolved. Furthermore, another major drawback of existing technologies lies in the fragmented nature of their processing procedures and the resulting safety blind spots. Whether through drug dissolution or theoretically possible physical fragmentation, the focus is solely on eliminating the thrombus itself, generally neglecting the new embolic risks posed by the tiny fragments generated after thrombus fragmentation. Currently, no approach can provide immediate, simultaneous fragment removal at the same time and site during thrombectomy. This separation of treatment and removal steps creates a time window for fragment escape, potentially limiting the clinical application of any effective thrombectomy method due to the risk of inducing embolism.

[0004] In summary, existing technologies face multiple challenges in treating PICC catheter-borne thrombosis, including effectiveness, safety, ease of operation, and functional integration. These issues are intertwined, creating a technological gap lacking an ideal solution. Developing a device that can penetrate deep into the catheter, efficiently and safely perform integrated thrombus disintegration and fragment removal, and provide clear operational guidance, is of urgent clinical need and significant application value. Summary of the Invention

[0005] In view of this, the purpose of this invention is to propose an integrated nursing device for dissolving thrombi in PICC catheters using ultrasonic technology. This device comprises a handheld unit integrating a Venturi negative pressure generating unit and a flushing fluid power unit, a disposable treatment head including a multi-segment flexible connecting tube that can adapt to catheter bending, a miniature ultrasonic transducer capable of cross-interference focusing, a three-layer coaxial cavity structure capable of simultaneous thrombus fragmentation and aspiration, and a mechanical feedback unit providing intuitive feedback on the flow status. This addresses the technical challenges of existing technologies, such as low efficiency in removing thrombi in catheters, cumbersome and experience-dependent procedures, the risk of embolism due to the separation of treatment and fragment removal steps, and the difficulty in integrating efficient treatment and immediate removal functions within millimeter-sized catheters.

[0006] This invention is achieved through the following technical solution:

[0007] An integrated care device for eliminating thrombi in PICC catheters using ultrasound, comprising a handheld main unit and a disposable treatment head;

[0008] The handheld host is equipped with a flushing fluid power unit, a Venturi negative pressure generator, and a control circuit inside its housing; the input end of the Venturi negative pressure generator is in fluid communication with the output end of the flushing fluid power unit.

[0009] The disposable treatment head is detachably connected to the front end of the handheld host via a quick-release structure;

[0010] The disposable treatment head includes a catheter interface adapter section, an integrated treatment probe, and a mechanical feedback unit;

[0011] The front end of the catheter interface adapter section is provided with a Luer lock connector, and the interior of the catheter interface adapter section is provided with multiple flexible connecting tubes.

[0012] The integrated treatment probe is fixedly disposed at the inner end of the catheter interface adapter section; the integrated treatment probe is coaxially disposed with an outer annular flushing chamber, a middle annular suction chamber and a central treatment chamber; the central treatment chamber is located on the innermost side, the middle annular suction chamber is sleeved on the outside of the central treatment chamber, and the outer annular flushing chamber is sleeved on the outside of the middle annular suction chamber;

[0013] A miniature ultrasonic transducer unit is fixedly installed inside the front end of the central treatment cavity; the miniature ultrasonic transducer unit includes a piezoelectric ceramic transducer and a dual-angle metal reflective cavity, and the dual-angle metal reflective cavity is fixedly installed in front of the piezoelectric ceramic transducer.

[0014] The outer annular flushing chamber is in fluid communication with the output end of the flushing fluid power unit; the middle annular suction chamber is in fluid communication with the negative pressure end of the Venturi negative pressure generator.

[0015] The mechanical feedback unit includes an observation window and an indicator buoy; the observation window is located on the fluid path connecting the middle annular suction chamber, and the indicator buoy is movably located inside the observation window.

[0016] Furthermore, the walls of the multi-segment flexible connecting pipe are provided with annular weakening zones spaced apart along the axial direction.

[0017] Furthermore, the multi-segment flexible connecting tube has shape memory alloy wires embedded inside its tube wall.

[0018] Furthermore, an ultrasonic driving circuit is also fixedly installed inside the housing of the handheld host, and the ultrasonic driving circuit is electrically connected to the miniature ultrasonic transducer unit.

[0019] Furthermore, the control circuit is connected to an acoustic impedance detection unit, which is electrically connected to the miniature ultrasonic transducer unit.

[0020] Furthermore, the handheld host has a status indicator light on its housing, and the status indicator light is electrically connected to the control circuit.

[0021] Furthermore, the quick-release structure includes an elastic buckle and a slot, with the elastic buckle located at the rear end of the disposable treatment head and the slot located at the front end of the handheld host.

[0022] Furthermore, the handheld host has a slot on its housing, and a pre-filled flushing fluid bag is placed in the slot and connected to the input end of the flushing fluid power unit through a pipeline.

[0023] The beneficial effects of this invention are as follows:

[0024] This invention utilizes an integrated nursing device that combines a Venturi negative pressure synchronous clearance structure, a cross-focused ultrasound thrombus fragmentation structure, and an adaptive flexible conduction structure. Through a highly integrated design of the handheld main unit and disposable treatment head, it enables a one-button start after connecting the PICC catheter, simultaneously completing the entire process of efficient thrombus fragmentation, immediate aspiration, and status feedback. Employing a cross-interference focused ultrasound generation structure based on a single crystal and dual-angle reflection cavities, a high-energy-density therapeutic sound field can be formed within the millimeter-level catheter lumen, achieving efficient and direct disintegration of both old and fresh thrombi, significantly improving the success rate and speed of thrombus clearance. The innovative fluid design, utilizing the Venturi effect to directly convert the kinetic energy of the flushing fluid into aspiration negative pressure, ensures that the thrombus is captured and cleared by the synchronously generated negative pressure field at the moment of fragmentation, fundamentally eliminating the risk of embolism caused by fragment escape in traditional methods and significantly improving the safety of the treatment process. By incorporating a multi-segment flexible connection structure that passively adapts to the curved path of the catheter within the body, coupled with intuitive mechanical flow status feedback indicators, the operation process eliminates the need for complex angle adjustments and experience-based judgments. This significantly reduces the operational threshold and mental burden on nursing staff, improving the standardization and convenience of clinical procedures. This invention integrates the traditionally separate, inefficient, and safety-risk multi-step processing steps into a safe, efficient, and easy-to-use single operation. It is expected to significantly improve patient prognosis and experience, and effectively reduce catheter removal and reinsertion due to treatment failures, thereby saving vascular access resources and overall medical costs. Attached Figure Description

[0025] Figure 1 For the overall assembly structure drawing;

[0026] Figure 2 This is a front view of the handheld device.

[0027] Figure 3 Side view of the handheld device;

[0028] Figure 4 Top view of the handheld host unit;

[0029] Figure 5 This is a sectional view of AA.

[0030] Figure 6 A frontal view of a disposable treatment head;

[0031] Figure 7 This is a cross-sectional view of a disposable treatment head.

[0032] Explanation of reference numerals in the attached figures:

[0033] 1. Handheld main unit; 3. Miniature peristaltic pump; 4. Venturi negative pressure generator; 5. Ultrasonic drive circuit board; 6. Control circuit board; 7. Rechargeable battery; 8. Slot; 10. Start button; 11. Intensity selection knob; 12. Status indicator light; 13. Elastic buckle; 14. Slot; 15. Catheter interface adapter section; 18. Luer lock male connector; 19. Multi-segment flexible connecting tube; 20. Annular weakening zone; 21. Joint segment; 22. Shape memory alloy wire; 23. Outer annular flushing chamber; 24. Middle annular suction chamber; 25. Central treatment chamber; 27. Piezoelectric ceramic transducer; 28. Dual-angle metal reflection chamber; 29. ​​Reflecting bevel; 30. Miniature thermocouple; 31. First medical tubing; 32. Second medical tubing; 33. Negative pressure port; 34. Discharge end; 37. Observation window; 38. Indicating buoy; 39. Acoustic impedance detection unit. Detailed Implementation

[0034] like Figure 1-7 As shown, one embodiment of the present invention provides an integrated nursing device for ultrasonic removal of thrombi in PICC catheters, comprising two main parts: a reusable handheld main unit 1 and a disposable treatment head. The handheld main unit 1 is elongated cylindrical for easy one-handed grip, and its housing is composed of upper and lower parts fixedly connected by snaps and screws. A circular connection port is located at the center of the front end of the housing. The disposable treatment head is detachably physically connected and electrically and fluidly communicated with the connection port at the front end of the handheld main unit 1 via a quick-release structure at its rear end.

[0035] The handheld main unit 1 has a compact internal structure. Along its long axis, from front to back, are a control circuit board 6, an ultrasonic drive circuit board 5, a miniature peristaltic pump 3, and a rechargeable battery 7. The control circuit board 6 serves as the core control unit, integrating a microprocessor, an acoustic impedance detection unit 39, and a temperature monitoring circuit. The ultrasonic drive circuit board 5 is located immediately behind the control circuit board 6 and is connected to it via a ribbon cable to generate high-voltage pulse signals. The miniature peristaltic pump 3 is fixed in the middle of the housing, and its inlet is connected to the internal interface of a slot 8 on the side of the housing via a medical silicone tube. The rechargeable battery 7 is located at the rear of the housing, providing power to the entire device. On the surface of the handheld main unit 1, above the grip area, is a start button 10 and a three-level intensity selection knob 11. A red-green dual-color status indicator light 12 is located near the front of the top of the housing. A rectangular slot 8 is located on the side of the housing for inserting and securing a pre-filled irrigation fluid bag. A puncture needle is installed inside the slot 8; when the irrigation fluid bag is inserted, it automatically punctures the bag's sealing membrane, allowing the fluid to flow into the connecting tubing.

[0036] The quick-release structure enables rapid connection and separation between the handheld host 1 and the disposable treatment head. Specifically, it comprises three L-shaped slots 14 evenly spaced on the circumference of the connection port at the front end of the handheld host 1. Correspondingly, a disc-shaped first connecting part is located at the rear end of the disposable treatment head, with three radially retractable elastic latches 13 on its outer edge. When the first connecting part of the disposable treatment head is aligned with and inserted into the connection port of the handheld host 1, rotating it clockwise by approximately 60 degrees causes the three elastic latches 13 to slide into the locking positions of the three slots 14, achieving a secure lock. This ensures that the multiple conductive pins and fluid interfaces inside the disposable treatment head are precisely aligned and connected with the corresponding contacts and interfaces inside the handheld host 1.

[0037] The disposable treatment head is the core component for performing the treatment function. It has a slender structure and consists of, from front to back, a catheter interface adapter section 15, an integrated treatment probe, and a mechanical feedback unit. The front end of the catheter interface adapter section 15 is a standard Luer lock male connector 18, whose threaded portion is used to tighten and connect with the external Luer lock female connector of the patient's PICC catheter. Behind the Luer lock male connector 18 is a multi-segment flexible connecting tube 19, which serves as the main body of the catheter interface adapter section 15. Its wall is integrally injection molded from medical-grade silicone. To allow it to passively adapt to the natural bending of the PICC catheter under the skin and within the blood vessel, three annular weakening zones 20 are set axially at certain intervals on the wall of the multi-segment flexible connecting tube 19. The wall thickness of these zones is significantly thinner than other parts, thus dividing the entire tube into two independently movable joint segments 21. Inside the silicone wall of each joint segment 21, four extremely fine NiTiN shape memory alloy wires 22 are uniformly embedded circumferentially. At room temperature (or outside the body), the multi-segment flexible connecting tube 19 is soft and easy to bend; when it enters the body during the treatment process and the temperature rises to close to body temperature, the shape memory alloy wire 22 undergoes a phase change and contraction, generating a gentle, centripetal tension force on the tube wall of the joint segment 21, so that each joint segment 21 can "remember" and maintain the formed bending posture, preventing unexpected angle changes due to fluid flow or slight external force during treatment.

[0038] The ends of the multi-segment flexible connecting tube 19 are sealed and fixed to the base of the integrated treatment probe with medical epoxy resin. The integrated treatment probe is the key to technological innovation. Its main body consists of three thin-walled stainless steel tubes of different diameters, which are sequentially sleeved with strict coaxiality and sealed at both ends by laser welding. These three layers of stainless steel tubes form three independent annular cavities: the gap between the outermost stainless steel tube and the middle stainless steel tube forms the outer annular flushing cavity 23; the gap between the middle stainless steel tube and the innermost stainless steel tube forms the middle annular suction cavity 24; and the central through hole of the innermost stainless steel tube forms the central treatment cavity 25. The three cavities are led out from the rear end of the probe through three independent medical hoses (31, 32), where the first medical hose 31 connects to the outer annular flushing cavity 23 and the second medical hose 32 connects to the middle annular suction cavity 24.

[0039] At the very front of the central treatment cavity 25, inside the opening of the innermost stainless steel tube 253, a miniature ultrasonic transducer unit is fixed with a high-temperature resistant adhesive. This unit consists of two core components: a square piezoelectric ceramic transducer 27 and a dual-angle metal reflector cavity 28. Two extremely thin, silver-plated wires are welded to the back electrode of the piezoelectric ceramic transducer 27, extending rearward and connecting to a flexible circuit that ultimately converges to an electrical interface at the rear of the disposable treatment head. The dual-angle metal reflector cavity 28 is precision-machined from a high-density copper-tungsten alloy, with an open V-shaped notch at its front end. The included angle of the two reflective bevels 29 has been acoustically optimized. The base of the reflector cavity 28 is fixed approximately 0.5 mm in front of the radiating surface of the piezoelectric ceramic transducer 27 by laser spot welding. When the piezoelectric ceramic transducer 27 is driven to vibrate longitudinally, the emitted spherical sound waves propagate to the reflecting inclined surface 29, are reflected, and change direction, forming two oblique high-energy sound beams with a certain angle between them. These two sound waves cross and superimpose in the space about 3-5 mm in front of the probe, forming a highly concentrated focusing area that precisely covers the inner diameter range of the PICC catheter, thereby achieving efficient mechanical fragmentation of the thrombus. In order to monitor the operating temperature in real time to prevent overheating, a miniature thermocouple 30 is also embedded between the ceramic substrate and the metal shell of the piezoelectric ceramic transducer 27, and its signal line is also led out backward.

[0040] The internal fluid path design of the handheld unit 1 cleverly embodies functional integration. The outlet of the micro peristaltic pump 3 is divided into two paths via a medical tee connector. The first path leads directly to the outer annular flushing chamber 23 of the disposable treatment head via a first medical hose 31. The second path connects to the inlet of the Venturi negative pressure generator 4. The Venturi negative pressure generator 4 is a miniature device with a gradually narrowing-expanding flow channel, fixed near the pump body. Its throat negative pressure port 33 is connected to the middle annular suction chamber 24 of the disposable treatment head via a second medical hose 32. Its outlet 34 is connected to a waste fluid collection bag via a third medical hose. When the micro peristaltic pump 3 is working, part of the pumped flushing fluid is directly used for catheter flushing, and the other part flows through the Venturi tube. According to the principles of fluid mechanics, the fluid speed increases and the pressure decreases when flowing through the throat, thereby generating a stable suction force at the negative pressure port 33. This suction force acts on the catheter lumen through the middle annular suction chamber 24, realizing negative pressure suction. This means that the ultrasonic energy required to break up the thrombus and the suction force required to remove the fragments are both driven by the same fluid flow system, achieving deep structural coupling.

[0041] To provide the operator with intuitive, reliable, and power-free status indication, a mechanical feedback unit is integrated into the section of the second medical tubing 32 near the handheld unit 1. This unit includes a transparent cylindrical observation window 37, connected to the tubing at both ends via Luer connectors. The inner diameter of the observation window 37 is slightly larger than the tubing, and a red cylindrical polypropylene indicator buoy 38 with a specific gravity of approximately 0.9 g / cm³ is placed within it. When the flow path is unobstructed and the fluid flow rate is high, the buoy 38 is pushed to the top of the observation window 37 (the upper part of the visible area); when larger thrombus fragments block the flow path, causing a decrease or stagnation in flow rate, the buoy 38 sinks to the bottom (the lower part of the visible area) due to gravity. This purely mechanical feedback method is simple, intuitive, and resistant to interference.

[0042] The acoustic impedance detection unit 39 integrated on the control circuit board 6 of the handheld host 1 collects the impedance signal of the miniature ultrasonic transducer unit in real time through electrical connection lines. When the medium in front of the transducer changes from a high-impedance blood clot to a low-impedance liquid, the impedance value will drop abruptly. The comparator circuit on the control circuit board 6 will capture this change, and when the impedance is lower than the set threshold, the drive status indicator 12 will change from red to green.

[0043] The workflow of this embodiment is as follows:

[0044] First, prepare by removing the disposable treatment head from the sterile packaging, aligning the first connector at its rear end with the connection port at the front end of the handheld unit 1, inserting it and rotating to lock it in place. A "click" sound indicates that the connection is complete. Then, fully push the pre-filled saline flushing bag into slot 8. Resistance indicates that the bag opening has been punctured and the tubing is connected.

[0045] Then, make the connection: After routine disinfection, tighten the Luer lock male head 18 at the tip of the disposable treatment head to the exposed interface of the patient's PICC catheter.

[0046] Next, the treatment is initiated: the operator presses the start button 10 with their thumb, and the device automatically executes the preset program. The micro-peristaltic pump 3 starts, pumping out saline solution, which enters the catheter for pre-flushing through the outer annular flushing chamber 23, while simultaneously driving the Venturi negative pressure generator 4 to generate suction. Almost simultaneously, the ultrasound drive circuit board 5 begins to output pulse signals, driving the micro-ultrasound transducer unit to generate cross-focused ultrasound waves, which act on the thrombus. The broken fragments are immediately drawn away by the synchronous negative pressure, passing through the middle annular suction chamber 24, the second medical tubing 32, the Venturi negative pressure generator 4, and the third medical tubing, finally entering the waste collection bag.

[0047] During treatment, the operator can monitor the process through two channels: first, by observing the position of the indicator float 38 of the mechanical feedback unit to determine whether the aspiration is unobstructed; second, by observing the color of the status indicator light 12, where red indicates the presence of a thrombus and green indicates that the current segment of the thrombus has been cleared. The built-in miniature thermocouple 30 continuously monitors the temperature to ensure safety.

[0048] Treatment complete: The device can be stopped automatically or manually once status indicator 12 turns green and indicator float 38 remains stable at a high position. Unscrew and discard the disposable treatment head; the process is now complete.

[0049] This embodiment achieves safe and efficient removal of thrombi within PICC catheters through an integrated design. It employs miniature cross-focused ultrasound technology, directly targeting the thrombus within the catheter, significantly improving fragmentation efficiency compared to traditional drug-based thrombolysis. The unique Venturi negative pressure design allows for simultaneous thrombus fragmentation and aspiration, fundamentally eliminating the risk of embolism caused by fragment detachment. The device is extremely easy to operate; treatment can be completed with a single button press after connecting the catheter, and intuitive status feedback is provided through a mechanical float and indicator lights, greatly reducing reliance on operator experience. It successfully solves multiple clinical challenges associated with traditional methods, such as uncertain efficacy, cumbersome operation, and insufficient safety.

[0050] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit it. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention, and all such modifications or substitutions should be covered within the scope of the claims of the present invention.

Claims

1. An integrated care device for ultrasonic elimination of thrombus within a PICC catheter, characterized in that: The application relates to a handheld host and a disposable treatment head. A washing liquid power unit, a Venturi negative pressure generator and a control circuit are fixedly arranged in the shell of the handheld host; the input end of the Venturi negative pressure generator is in fluid communication with the output end of the washing liquid power unit; The disposable treatment head is detachably connected with the front end of the handheld host through a quick release structure. The disposable treatment head comprises a catheter interface adapting section, an integrated treatment probe and a mechanical feedback unit. The front end of the catheter interface adapting section is provided with a luer lock connector, and the inside of the catheter interface adapting section is provided with a plurality of flexible connecting pipes. The integrated treatment probe is fixedly arranged at the inner end of the catheter interface adapting section; the inside of the integrated treatment probe is coaxially provided with an outer annular washing cavity, a middle annular suction cavity and a central treatment cavity; the central treatment cavity is located at the innermost side, the middle annular suction cavity is sleeved outside the central treatment cavity, and the outer annular washing cavity is sleeved outside the middle annular suction cavity. A miniature ultrasonic transducing unit is fixedly arranged at the inner front end of the central treatment cavity; the miniature ultrasonic transducing unit comprises a piezoelectric ceramic transducer and a double-angle metal reflection cavity, and the double-angle metal reflection cavity is fixedly arranged in front of the piezoelectric ceramic transducer. The outer annular washing cavity is in fluid communication with the output end of the washing liquid power unit, and the middle annular suction cavity is in fluid communication with the negative pressure end of the Venturi negative pressure generator. The mechanical feedback unit comprises an observation window and an indicating float; the observation window is arranged on a fluid path connected with the middle annular suction cavity, and the indicating float is movably arranged in the observation window.

2. The integrated care device for ultrasonic elimination of thrombus in a PICC catheter according to claim 1, characterized in that: Annular weakened zones are arranged on the pipe wall of the plurality of flexible connecting pipes in an axial direction.

3. The integrated care device for ultrasonic elimination of thrombus in a PICC catheter according to claim 2, characterized in that: Shape memory alloy wires are embedded in the pipe wall of the plurality of flexible connecting pipes.

4. The integrated care device for ultrasonic elimination of thrombus in a PICC catheter according to claim 1, characterized in that: An ultrasonic driving circuit is further fixedly arranged in the shell of the handheld host, and the ultrasonic driving circuit is electrically connected with the miniature ultrasonic transducing unit.

5. The integrated care device for ultrasonic elimination of thrombus in a PICC catheter according to claim 4, characterized in that: An acoustic impedance detection unit is connected with the control circuit, and the acoustic impedance detection unit is electrically connected with the miniature ultrasonic transducing unit.

6. The integrated care device for ultrasonic elimination of thrombus in a PICC catheter according to claim 1, characterized in that: A state indicating lamp is arranged on the shell of the handheld host, and the state indicating lamp is electrically connected with the control circuit.

7. The integrated care device for ultrasonic elimination of thrombus in a PICC catheter according to claim 1, characterized in that: The quick release structure comprises an elastic buckle and a clamping groove; the elastic buckle is arranged at the rear end of the disposable treatment head, and the clamping groove is arranged at the front end of the handheld host.

8. The integrated care device for ultrasonic elimination of thrombus in a PICC catheter according to claim 1, characterized in that: An insertion groove is arranged on the shell of the handheld host, and a pre-filled washing liquid bag is placed in the insertion groove and connected with the input end of the washing liquid power unit through a pipeline.

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