Acne-removing gel containing banana fruit extract and preparation method of acne-removing gel

Abstract

The invention relates to an acne-removing gel containing a plantain fruit extract and a preparation method of the acne-removing gel. The acne-removing gel is prepared from the following components: the plantain fruit extract, a skin conditioner, picolinin, a thickening agent, a preservative, a neutralizing agent, propylene glycol, allantoin and deionized water. Through selection of the effective components and reasonable matching of the use amounts of all the components, by means of the synergistic interaction effect of the Pinonin, the banana fruit extract, the skin conditioner and multiple moisturizing components, generation of acnes is inhibited, water-oil balance is adjusted, healing of acnes is accelerated, acne marks are faded in the aspects of inhibiting pathogenic bacteria of acnes, adjusting secretion of sebaceous glands and promoting keratin metabolism, and the skin care product has the effects of whitening skin, whitening skin and whitening skin. Therefore, a good acne removing effect is achieved, and the product is mild and safe.

Description

Technical Field

[0001] This invention belongs to the field of daily chemical products, specifically relating to an acne-removing gel containing banana fruit extract and its preparation method. Background Technology

[0002] At any age, various factors such as increased sebum production during puberty, hormonal imbalances and endocrine disorders caused by excessive work stress, and UV damage can all damage the skin barrier, leading to an imbalance of oil and water secretion and making the skin prone to acne. Acne scars typically fade within about a month with normal basal metabolic rate. As we age, our basal metabolic rate decreases significantly, and the reduced metabolic rate of skin cells can result in stubborn acne scars and increased pigmentation on the face. Therefore, to fundamentally improve these skin problems, skincare products should not only have anti-inflammatory and acne-reducing effects but also promote microvascular blood circulation, accelerate skin cell metabolism, and activate cells, thus preventing acne breakouts, acne scars, and increased pigmentation. Improving skin cell metabolism to treat acne while ensuring no acne scars remain, fading pigmentation, reducing pigmentation formation, and minimizing subsequent acne breakouts are key skincare issues that need to be addressed in this field.

[0003] Current acne treatment products mainly contain salicylic acid and piracetam, which have drawbacks such as limited effectiveness, high irritation, and significant rebound effects. While natural plant-based, traditional Chinese medicine, or a combination of both are safer methods that regulate sebum production to address the root cause of acne, these methods are time-consuming and leave lasting marks that are difficult to completely remove. Therefore, there is an urgent need to develop an acne gel that addresses these issues. Summary of the Invention

[0004] The technical problem to be solved by this invention is to provide an acne-removing gel containing banana fruit extract and its preparation method. This acne-removing gel, through the selection of effective ingredients and the reasonable combination of the dosage of each component, relies on the synergistic effect of piracetam, banana fruit extract, skin conditioning agents, and multiple moisturizing ingredients to inhibit the formation of acne, regulate sebaceous gland secretion, and promote keratin metabolism, thereby inhibiting the formation of acne, regulating water-oil balance, accelerating the healing of acne, and fading acne scars, thus achieving a good acne-removing effect. Moreover, this product is gentle and safe.

[0005] The technical solution adopted by the present invention to solve the above problems is as follows:

[0006] On one hand, the present invention provides an acne-removing gel containing banana fruit extract, comprising the following components by weight percentage:

[0007] 3-8% banana fruit extract;

[0008] Skin conditioning agent 0.1-5%;

[0009] Pianonine 0.003-0.008%;

[0010] Thickener 0.5-2%;

[0011] Preservatives: 0.2%-0.8%;

[0012] Neutralizing agent 0.1-0.4%;

[0013] Propylene glycol 6-9%;

[0014] Allantoin 0.1-0.2%;

[0015] Add deionized water to bring the level to 100%.

[0016] In the aforementioned technical solution, the structure of Pionin (INCI: Quaternary Ammonium Salt-73) is very similar to that of cyan dye. Its structure contains a thiazide ring, which is a nitrogen-containing heterocycle attached to the N site of the heptyl group. Propionibacterium acnes is a key pathogen causing acne; its excessive proliferation leads to inflammation and redness. Pionin, even at low doses, can still effectively inhibit Propionibacterium acnes by disrupting the bacterial cell membrane structure and interfering with its metabolic processes, effectively inhibiting bacterial growth and reproduction from the root cause, thereby achieving an acne-removing effect.

[0017] Among them, banana fruit (MUSA SAPIENTUM.) extract is extracted by grinding and crushing the peel of the banana plant. The phytosterols it contains directly protect the skin by delaying the formation of the skin's inflammatory matrix (redness, swelling). It is rich in vitamins A and C, which can help remove internal skin metabolites and scars, and has a whitening effect. Banana fruit extract also contains steroidal saponins, triterpenoids, sugars, and other components, which can tighten pores, reduce sebum secretion, and activate luciferase, resulting in a good anti-inflammatory effect. Banana fruit extract is like a "comprehensive warrior," with a gentler and more comprehensive nature. It can not only replenish the skin's moisture and help the stratum corneum retain moisture, but also help tighten pores, reduce sebum secretion, soften and smooth the skin, promote cell repair and renewal, help resist external stimuli, soothe the skin, and help remove internal skin metabolites and scars, while also having a whitening effect and fading acne marks.

[0018] Among them, skin conditioning agents can regulate the skin's oil-water balance, improve the skin's stratum corneum, and also have antibacterial, anti-inflammatory, and antioxidant effects. They can maintain a good balance of the skin's surface microecology, inhibit the occurrence of acne from the root, and accelerate the healing of acne, thus achieving a good acne removal effect.

[0019] Furthermore, the moisturizing factor propylene glycol in the above formula not only provides hydration to the skin, delays moisture loss, increases dermal-epidermal water penetration, temporarily protects the skin from damage, and promotes the repair process, but it is also an excellent organic solvent that can effectively dissolve pyrin, transforming it from a solid state to a homogeneous liquid state. The moisturizing factor allantoin not only acts as a humectant but also has anti-inflammatory effects, promoting cell growth, influencing the rapid granulation process of the epidermis, accelerating skin renewal, reducing wound inflammation, and thus accelerating the healing process of tissue wounds. Propylene glycol and allantoin can help restore the oil-water balance while repairing acne-prone skin, thereby maintaining skin hydration.

[0020] The acne-removing gel containing banana fruit extract of this invention, through the selection of effective ingredients and the reasonable combination of the dosage of each component, relies on the synergistic effect of piracetam, banana fruit extract, skin conditioning agents and multiple moisturizing ingredients to inhibit the formation of acne, regulate sebaceous gland secretion and promote keratin metabolism, thereby inhibiting the formation of acne, regulating water-oil balance, accelerating the healing of acne and fading acne scars, thus achieving a good acne-removing effect. Moreover, this product is gentle and safe.

[0021] Furthermore, the extraction method for the banana fruit extract includes the following steps:

[0022] S1. Extraction of Vitamin C: Take ripe, fresh banana pulp, cut it into small pieces, add pre-cooled 2wt% metaphosphate solution, homogenize at high speed for 2-3 minutes under ice bath conditions until the tissue is completely broken, and obtain a homogenate; transfer the homogenate to a brown bottle and place it in a dark environment at 4℃ for 2-4 hours, then centrifuge it at 4℃ and 8000-10000 rpm for 15-20 minutes; the supernatant after centrifugation is the sample extract containing Vitamin C, and the lower layer after centrifugation is the fruit pomace;

[0023] This step involves operating at low temperatures to reduce oxidation, and transferring the homogenate to a brown bottle for extraction in a dark environment is also intended to reduce oxidation.

[0024] S2. Extraction of steroidal saponins and triterpenoids: Extract the pomace or ripe fresh banana pulp by hot reflux with 60%-70% ethanol for 1.5 hours. Filter to obtain the first filtrate and residue. Add fresh 60%-70% ethanol to the residue, reflux for 1 hour, and filter again to obtain the second filtrate. Combine the two filtrates to obtain the final filtrate. Concentrate the filtrate under reduced pressure to recover the ethanol, obtaining an extract. Disperse the extract with deionized water to prepare a solution with a concentration of 0.1-0.5 g / mL. If flocculent precipitate is present, filter or centrifuge at low speed, and use the supernatant as the loading solution. Pass the loading solution through a resin column, then rinse the resin column with deionized water until the eluent is colorless. Elute with 50%-95% ethanol, collect the ethanol eluent, recover the ethanol under reduced pressure, and concentrate to obtain an extract enriched with steroidal saponins and triterpenoids.

[0025] S3. Extraction of fat-soluble components: Take the above-mentioned fruit residue or another ripe fresh banana pulp, dry and crush it into 1000-mesh powder, irradiate the powder under sunlight for 5 hours, and then irradiate it with ultraviolet light for 1 hour; then put the powder into an extraction vessel, use supercritical CO2 for circulating extraction, collect the liquid at the bottom of the separation vessel, and obtain an extract containing fat-soluble components.

[0026] S4. Mix the sample extract, extract, and extract solution, and then use spray drying or vacuum freeze drying to make powder to obtain the banana fruit extract.

[0027] This extraction method uses different extraction steps to extract vitamin C, steroidal saponins, triterpenoids, and fat-soluble components (phytosterols) from banana fruit. The resulting banana fruit extract can contain as many of the effective components as possible from the banana fruit, thus making its effects more comprehensive and its acne-removing effect better.

[0028] Furthermore, in step S3, the conditions for supercritical CO2 cyclic extraction are: extraction temperature of 40-60℃, extraction pressure of 15-30MPa, CO2 flow rate of 20kg / h, and extraction time of 4-4.5h.

[0029] Furthermore, the skin conditioning agent is a combination of two or more of the following: dipotassium glycyrrhizate, black willow bark extract, kudzu root extract, gentian dual-factor anti-allergy agent BG, sodium PCA, triterpenoid, SymCalmin 143535, nicotinamide, panthenol, and asiaticoside II.

[0030] Furthermore, the thickener is a carbomer polymer.

[0031] In the above technical solution, carbopol is a type of polymer widely used in cosmetics, mainly as a thickener, suspending agent and gel matrix. Carbopol U10 and Carbopol U20 are preferred thickeners. The gels made by Carbopol U10 and Carbopol U20 have a lighter texture and are suitable for systems containing more electrolytes or active ingredients.

[0032] Furthermore, the preservative is one or more of p-hydroxyacetophenone and hexanediol.

[0033] In the aforementioned technical solutions, the preservatives function in two ways: first, they interfere with the enzyme system of microorganisms, disrupting their normal metabolism and inhibiting enzyme activity, causing microbial proteins to coagulate and denature, thus interfering with their survival and reproduction; second, they alter cell membrane permeability, inhibiting the elimination of enzymes and metabolic products from within the microorganisms, leading to their inactivation. In cosmetics, preservatives primarily prevent the formation of colonies of thermostable Escherichia coli, Pseudomonas aeruginosa, molds, and yeasts.

[0034] Furthermore, the neutralizing agent is one or more of sodium hydroxide, potassium hydroxide, and triethanolamine.

[0035] In the above technical solution, the neutralizing agent serves two purposes: first, it neutralizes the carbomer thickener, as carbomer needs to be neutralized to form a gel; second, it adjusts the pH value of the formula, maintaining the product's pH value within a suitable range for the skin, and avoiding skin irritation due to excessive acidity or alkalinity.

[0036] On the other hand, the present invention provides a method for preparing the above-mentioned acne-removing gel containing banana fruit extract, characterized by comprising the following steps:

[0037] (1) Mix piocin with propylene glycol and heat until the yellow powder dissolves to form a yellow transparent liquid, thus obtaining phase B;

[0038] (2) Slowly sprinkle the thickener into deionized water, let it stand at room temperature to hydrate until there are no white lumps in the thickener, and obtain the aqueous phase;

[0039] The purpose of slowly adding the thickener to the deionized water in this step is to prevent the thickener from clumping.

[0040] (3) Add allantoin to the aqueous phase, stir and heat to 85-90℃, keep the temperature until the material is uniform and free of white powder, stir and cool to room temperature;

[0041] (4) Add a neutralizing agent to adjust the pH to 5.5-6.5, then add the preservative, phase B, banana fruit extract and skin conditioner in sequence, stir well and then discharge.

[0042] The preparation method of the acne-removing gel containing banana fruit extract of the present invention is simple, easy to operate, and suitable for industrial production.

[0043] The present invention has the following beneficial effects:

[0044] 1. The acne-removing gel containing banana fruit extract of the present invention, through the selection of effective ingredients and the reasonable combination of the dosage of each component, relies on the synergistic effect of piracetam, banana fruit extract, skin conditioning agents and multiple moisturizing ingredients to inhibit the formation of acne, regulate sebaceous gland secretion and promote keratin metabolism, thereby inhibiting the formation of acne, regulating water-oil balance, accelerating the healing of acne and fading acne marks, thus achieving a good acne-removing effect. Moreover, the product is gentle and safe. The preparation method of the acne-removing gel containing banana fruit extract is simple, easy to operate and suitable for industrial production.

[0045] 2. The extraction method of banana fruit extract of the present invention uses different extraction steps to extract vitamin C, steroidal saponins, triterpenoids and fat-soluble components (phytosterols) from banana fruit. The resulting banana fruit extract can contain as many effective components as possible from banana fruit, thus making its effects more comprehensive and its acne-removing effect better. Detailed Implementation

[0046] To make the technical problems, solutions, and advantages of this invention clearer, a detailed description will be provided below with reference to specific examples. However, the scope of protection of this invention is not limited to the following specific embodiments. The described embodiments are merely some, not all, of the embodiments of this invention, and are not intended to limit the invention. Based on the embodiments of this invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this invention.

[0047] Unless otherwise defined, all technical terms used herein have the same meaning as commonly understood by those skilled in the art. The technical terms used herein are for the purpose of describing particular embodiments only and are not intended to limit the scope of the invention.

[0048] Unless otherwise specified, all raw materials, reagents, instruments and equipment used in this invention can be purchased from the market or prepared by existing methods.

[0049] Examples 1-4 of the present invention provide an acne-removing gel containing banana fruit extract, and Comparative Examples 1-3 provide an acne-removing gel. The contents in the formulas are all by mass percentage.

[0050] Table 1. Raw material formulations (%) for the examples and comparative examples

[0051]

[0052]

[0053] Among them, Pueraria lobata extract was purchased from Guangzhou Miaosen Biotechnology Co., Ltd., black willow bark extract was purchased from Guangzhou Zhaohan Trading Co., Ltd., gentian dual-factor anti-allergy agent BG was purchased from Guangzhou Ganeng Biotechnology Co., Ltd., triterpenoid was purchased from Guangzhou Jiaye Biotechnology Co., Ltd., and asiaticoside-II was purchased from Guangzhou Jiaye Biotechnology Co., Ltd.

[0054] The preparation method of banana fruit extract includes the following steps:

[0055] The extraction method for the banana fruit extract includes the following steps:

[0056] S1. Extraction of Vitamin C: Take ripe, fresh banana pulp, cut it into small pieces, add pre-cooled 2wt% metaphosphate solution, homogenize at high speed for 3 minutes under ice bath conditions until the tissue is completely broken, and obtain a homogenate; transfer the homogenate to a brown bottle and place it in a dark environment at 4℃ for 3 hours, then centrifuge it at 4℃ and 10000 rpm for 15 minutes; the supernatant after centrifugation is the sample extract containing Vitamin C, and the lower layer after centrifugation is the fruit residue;

[0057] S2. Extraction of steroidal saponins and triterpenoids: Extract the pomace or ripe fresh banana pulp by hot reflux with 70% ethanol for 1.5 h. Filter to obtain the first filtrate and residue. Add fresh 70% ethanol to the residue, reflux for 1 h, and filter to obtain the second filtrate. Combine the two filtrates to obtain the final filtrate. Concentrate the filtrate under reduced pressure to recover the ethanol, obtaining an extract. Disperse the extract with deionized water to prepare a solution with a concentration of 0.5 g / mL, which is used as the loading solution. Pass the loading solution through a resin column, then rinse the resin column with deionized water until the eluent is colorless. Elute with 85% ethanol, collect the ethanol eluent, recover the ethanol under reduced pressure, and concentrate to obtain an extract enriched with steroidal saponins and triterpenoids.

[0058] S3. Extraction of fat-soluble components: Take the above-mentioned fruit pomace or other ripe fresh banana pulp, dry and crush it into 1000-mesh powder, irradiate the powder under sunlight for 5 hours, and then irradiate it with ultraviolet light for 1 hour; then put the powder into an extraction vessel, and use supercritical CO2 for circulating extraction, collect the liquid at the bottom of the vessel, and obtain an extract containing fat-soluble components; the conditions for supercritical CO2 circulating extraction are: extraction temperature of 50℃, extraction pressure of 20MPa, CO2 flow rate of 20kg / h, and extraction time of 4h;

[0059] S4. Mix the sample extract, extract, and extract solution, and freeze-dry them under vacuum to obtain the banana fruit extract.

[0060] The preparation method of the acne-removing gel containing banana fruit extract in the above embodiments is as follows:

[0061] (1) Mix piocin with propylene glycol and heat until the yellow powder dissolves to form a yellow transparent liquid, thus obtaining phase B;

[0062] (2) Slowly sprinkle the thickener into deionized water, let it stand at room temperature to hydrate until there are no white lumps in the thickener, and obtain the aqueous phase;

[0063] (3) Add allantoin to the aqueous phase, stir and heat to 85°C, keep warm until the material is uniform and free of white powder, stir and cool to room temperature;

[0064] (4) Add a neutralizer to adjust the pH to 6, then add the preservative, phase B, banana fruit extract and skin conditioner in sequence, stir well and then discharge.

[0065] The preparation method for the comparative acne gel is similar. If there are components that are not added or replaced, they can be removed or replaced in the corresponding preparation steps.

[0066] Consumer testing and efficacy instrument evaluation were conducted on the acne-removing gels of the above embodiments and comparative examples.

[0067] Seventy participants aged 20-60 with mild to moderate acne (i.e., noticeable pimples and acne scars) and oily or combination skin were randomly divided into seven groups of ten. Each group received one sample. Participants rated the acne-reducing and oil-controlling effects on their skin before and 12 weeks after sample use, with 1 being considered insignificant and 10 being the best. Changes in acne and acne scars were observed using a VISA skin analyzer, the skin barrier repair effect was assessed using a TEWL (transepidermal water loss) meter, and sebum secretion was measured before and after use using a Sebumeter. The test results are shown in Table 2.

[0068] Table 2 Performance test results of the examples and comparative samples

[0069]

[0070]

[0071] The test results above show that, compared with the comparative product, the product of this invention has significantly better acne-removing, oil-controlling, and moisturizing effects. This indicates that when banana fruit extract, Piperine, and two or more of the above-mentioned skin conditioning agents are added to the acne-removing gel, it can achieve excellent acne-removing, oil-controlling, and moisturizing effects.

[0072] By comparing Example 1 and Comparative Examples 1-3, it can be seen that removing any one of the banana fruit extract, skin conditioning agent, or piocin will have a significant impact on the acne-removing effect of the product. This indicates that when banana fruit extract and piocin are added to the acne-removing gel at the same time, and two or more of the above-mentioned skin conditioning agents are combined, a synergistic effect of 1+1+1>3 can be achieved.

[0073] The preferred embodiments of the present invention have been described in detail above. However, the present invention is not limited to the specific details in the above embodiments. Within the scope of the technical concept of the present invention, various simple modifications can be made to the technical solution of the present invention, and these simple modifications all fall within the protection scope of the present invention.

[0074] It should also be noted that the various specific technical features described in the above embodiments can be combined in any suitable manner without contradiction. To avoid unnecessary repetition, the present invention will not describe the various possible combinations separately.

[0075] Furthermore, various different embodiments of the present invention can be combined in any way, as long as they do not violate the spirit of the present invention, they should also be regarded as the content disclosed by the present invention.

Claims

1. A spot treatment gel comprising a plantain fruit extract, characterized in that, The following components by mass percentage: Plantain fruit extract 3-8%; Skin conditioning agent 0.1-5%; Paeonia extract 0.003-0.008%; Thickening agent 0.5-2%; Preservative 0.2%-0.8%; Neutralizing agent 0.1-0.4%; Propylene glycol 6-9%; Allantoin 0.1-0.2%; Deionized water to 100%.

2. The Prone Gel with Plantain Fruit Extract according to claim 1, characterized in that, The extraction method of the plantain fruit extract comprises the following steps: S1. Extracting vitamin C: take fresh ripe plantain pulp, cut into small pieces, add pre-cooled 2wt% metaphosphoric acid solution, homogenize at high speed for 2-3min under ice bath condition until the tissue is completely broken, obtain homogenate; transfer the homogenate to a brown bottle and immerse it in a dark environment at 4℃ for 2-4h, then centrifuge it at 8000-10000rpm at 4℃ for 15-20min; the supernatant after centrifugation is the sample extract containing vitamin C, and the lower material after centrifugation is the residue; S2. Extracting steroidal saponins and triterpenoid components: take the residue or another fresh ripe plantain pulp, hot reflux extract with 60%-70% ethanol for 1.5h, filter to obtain the primary filtrate and residue, add new 60%-70% ethanol to the residue, reflux extract for 1h and filter to obtain the secondary filtrate, combine the two filtrates to obtain the filtrate; concentrate the filtrate under reduced pressure to recover ethanol, obtain the extract, disperse the extract with deionized water to prepare a solution with a concentration of 0.1-0.5g / mL; if there is flocculent precipitate, filter or low-speed centrifuge, take the supernatant as the sample loading liquid; pass the sample loading liquid through a resin column, then rinse the resin column with deionized water until the effluent is colorless; elute with 50%-95% ethanol, collect the ethanol eluate, recover ethanol under reduced pressure and concentrate to obtain the extract rich in steroidal saponins and triterpenoid components; S3. Extracting fat-soluble components: take the above residue or another fresh ripe plantain pulp, dry and crush into 1000 mesh powder, irradiate the powder under sunlight for 5h, then irradiate with ultraviolet light for 1h; then load the powder into an extraction kettle, perform cyclic extraction with supercritical CO2, collect the liquid at the bottom of the separation kettle to obtain the extract containing fat-soluble components; S4. Mix the sample extract, extract and extract liquid, and prepare a powder by spray drying or vacuum freeze drying to obtain the plantain fruit extract.

3. The anti-acne gel containing plantain fruit extract according to claim 2, characterized in that, In step S3, the cyclic extraction with supercritical CO2 is performed under the following conditions: extraction temperature 40-60℃, extraction pressure 15-30MPa, CO2 flow rate 20kg / h, extraction time 4-4.5h.

4. The Prone Gel with Plantain Fruit Extract according to claim 1, characterized in that, The skin conditioning agent is a combination of two or more of dipotassium glycyrrhizinate, black willow bark extract, wild kudzu root extract, gentian double-factor anti-sensitivity factor BG, PCA sodium, tripeptin, SymCalmin 143535, nicotinamide, panthenol and asiaticoside-II.

5. The Prone Gel with Plantain Fruit Extract according to claim 1, characterized in that, The thickening agent is carbomer polymer.

6. The Prone Gel with Plantain Fruit Extract according to claim 1, characterized in that, The preservative is one or more of p-hydroxyacetophenone and hexanediol.

7. The Prone Gel with Plantain Fruit Extract according to claim 1, characterized in that, The neutralizing agent is one or more of sodium hydroxide, potassium hydroxide and triethanolamine.

8. A method of preparing a gel containing plantain fruit extract for acne treatment according to any one of claims 1 to 7, characterized in that, The following steps are included: (1) Mix the paeonol with propylene glycol and heat to dissolve the yellow powder, making a yellow transparent liquid, obtaining phase B; (2) Slowly sprinkle the thickening agent into deionized water, and hydrate at room temperature until the thickening agent has no white lumps, obtaining the water phase; (3) Add allantoin to the water phase, stir and heat to 85-90℃, keep warm until the material is uniform and there is no white powder, cool to room temperature; (4) Add the neutralizing agent to it, adjust pH to 5.5-6.5, and then add the preservative, phase B, plantain fruit extract, and skin conditioner in sequence, stir until uniform, and then discharge.

Images