Micro blood layering device based on pharmacokinetics

Abstract

The invention belongs to the technical field of centrifugal equipment, and discloses a pharmacokinetics-based trace blood layering device which comprises a shell and a cover body, and further comprises a transmission mechanism and a driving mechanism which are mounted in the shell, and a blood storage assembly is mounted on the transmission mechanism; the transmission mechanism comprises a main shaft, a second gear and two first gears meshed with each other, and one first gear is fixedly arranged on the main shaft in a sleeving mode. According to the scheme, by pressing the spring combined valve element, gas in the pressure storage mechanism instantly enters the arc-shaped sleeve through the first valve element channel, then the second gear drives the main shaft to rotate through the two first gears, and the blood storage assembly rotates at a high speed along with the main shaft; at the moment, blood in the blood storage assembly is layered under the conditions that the main shaft is quickly started and rotates at a high speed for a short time, so that the problem that the overall implementation efficiency is reduced due to the fact that a gravity sedimentation method is adopted or the working time of the centrifugal machine is prolonged is solved.

Description

Technical Field

[0001] This invention belongs to the field of centrifugation equipment technology, specifically a micro-blood stratification device based on pharmacokinetics. Background Technology

[0002] Pharmacokinetic experiments aim to study the absorption, distribution, metabolism and excretion of drugs in the body. They usually require multiple, frequent collection of small blood samples (often tens of microliters) from the same subject and analysis of blood drug concentrations.

[0003] After blood collection, pure plasma needs to be separated from the blood so that the drug concentration can be measured immediately or quickly, thereby assisting in clinical drug monitoring or new drug development.

[0004] Operators typically use gravity sedimentation or centrifugation to separate the collected blood into layers. While gravity sedimentation is simple to operate, it is time-consuming.

[0005] For centrifugation, blood is placed in special blood collection tubes and centrifuged at high speed, forming clear three layers. However, this method is often unsatisfactory for small amounts of blood. During high-speed centrifugation of small samples, the interface between the blood cell layer and the plasma layer may not be clear and sharp enough. Therefore, to ensure more obvious stratification of small amounts of blood during centrifugation, operators usually increase the centrifugation time. However, since the centrifuge takes a lot of time to start up, accelerate, and reach a stable high-speed state (usually accounting for 30%-50% of the entire centrifugation cycle), this actually leads to a significant decrease in overall sample processing efficiency. Pharmacokinetic studies require high-frequency sampling, and each centrifugation delay accumulates into an overall extended experimental cycle, affecting the timeliness of real-time blood drug concentration monitoring. Especially during critical time points in clinical emergency drug use or new drug development, this may lead to data lag or decision-making delays. Further increasing the centrifugation time would directly reduce the overall experimental efficiency.

[0006] Therefore, in order to solve the above problems, a micro-blood stratification device based on pharmacokinetics is proposed. Summary of the Invention

[0007] To address the problems mentioned in the background art, the present invention provides a pharmacokinetic-based micro-blood stratification device, which addresses the issue that gravity sedimentation or extending centrifuge operating time reduces overall efficiency.

[0008] To achieve the above objectives, the present invention provides the following technical solution: a pharmacokinetic-based micro-blood stratification device, comprising a shell and a cover, and further comprising: a transmission mechanism and a drive mechanism installed in the shell, wherein a blood storage component is installed on the transmission mechanism; The transmission mechanism includes a main shaft, a second gear, and two meshing first gears. One first gear is fixedly mounted on the main shaft, while the other first gear and the second gear are rotatably connected to the bottom of the housing and mesh with each other. The main shaft is rotatably connected to the bottom of the housing. The driving mechanism includes an arc-shaped sleeve fixedly installed at the bottom of the housing. An arc-shaped piston rod is movably sleeved inside the arc-shaped sleeve. Several spring pins are hinged at equal angles on the arc-shaped piston rod. Several arc-shaped stops for supporting the corresponding spring pins are also provided on the arc-shaped piston rod. The spring pins can be engaged in the tooth portion of the gear. The housing is provided with a pressure accumulator mechanism for pumping air into the arc-shaped sleeve, and the housing is also provided with a valve mechanism for controlling the conduction of the arc-shaped sleeve and the pressure accumulator mechanism. A frame is fixed to the top of the main shaft, and several blood storage components are installed in a circular array on the frame.

[0009] Preferably, the inner diameter of the opening at the end of the arc-shaped sleeve is smaller than the outer diameter of the piston end of the arc-shaped piston rod, and the piston end of the arc-shaped piston rod is always inside the arc-shaped sleeve.

[0010] Preferably, the valve mechanism includes a sleeve fixedly installed on the outer periphery of the housing, a spring combination valve core is movably installed inside the sleeve, the top end of the spring combination valve core extends to the outside of the sleeve, and the portion of the spring combination valve core located inside the sleeve has a valve core channel one and a valve core channel two. In the initial state, the arc-shaped sleeve can communicate with the outside through the valve core channel two. When the spring-loaded valve core moves downward, it enables the accumulator mechanism to connect with the arc-shaped sleeve through the valve core channel.

[0011] Preferably, the top end of the spring combination valve core is hinged with a second spring pin, one end of which can extend to the top edge of the housing and overlap with the top edge of the housing in the vertical direction; The cover can be threaded to the top of the housing, and when the cover moves downwards from the top of the housing, it can compress the spring pins to rotate around the axis, thereby causing the two ends of the spring pins to be misaligned with the edge of the top of the housing in the vertical direction.

[0012] Preferably, the pressure accumulator includes a pressure tube fixedly installed at the bottom of the housing. The upper part of the pressure tube can pass through the housing and the main shaft and is movably sleeved in the main shaft. A piston rod is movably sleeved on the upper part of the pressure tube. A one-way valve II with downward unidirectional flow is installed in the cavity of the piston rod. A one-way valve I with downward unidirectional flow is installed in the cavity of the pressure tube below the piston rod. A pipe is fixedly connected to the bottom of the pressure tube. The other end of the pipe is fixedly installed on the outer periphery of the sleeve. Initially, the end of the pipe is blocked by the outer periphery of the spring combination valve core.

[0013] Preferably, the diameter of the top of the piston rod is larger than the diameter of the bottom of the piston rod, and the piston rod can move upward and disengage from the pressure tube.

[0014] Preferably, a frame is fixedly connected to the top of the main shaft, and the blood storage component is plugged into and installed on the frame.

[0015] Preferably, the blood storage assembly includes a piston cylinder vertically and movably mounted on a frame, a spring piston rod movably mounted on the piston cylinder, the top end of the spring piston rod extending to the outside of the piston cylinder, one-way valve one and one-way valve two installed inside the piston cylinder, an acrylic storage vessel fixedly connected to the piston cylinder, and a cap installed at the other end of the acrylic storage vessel; The acrylic storage vessel can be connected to the piston cylinder in one-way communication through a one-way valve, and the piston cylinder cavity can be connected to the outside world in one-way communication through a one-way valve.

[0016] Preferably, the frame can support the acrylic storage tube, and one end of the cap abuts against the frame.

[0017] Compared with the prior art, the beneficial effects of the present invention are as follows: The above solution uses a spring-loaded valve core to allow gas in the accumulator to enter the arc-shaped sleeve instantly through the valve core channel. This pushes the arc-shaped piston rod, causing the spring clip 1 to move. The spring clip 1 on the arc-shaped piston rod then engages with the teeth of gear 2, causing gear 2 to rotate. Gear 2 then drives the main shaft to rotate through two sets of gears 1, causing the blood storage component to rotate at high speed. Under the conditions of rapid start-up of the main shaft and short-term high-speed rotation, the blood in the blood storage component will be separated into layers, thus solving the problem that gravity sedimentation or extending the centrifuge working time would reduce the overall efficiency. The above solution prevents the spring combination valve core from descending when the cover is not closed before the operator presses the spring combination valve core. When the operator closes the cover, the edge and outer periphery of the cover will press the upper surface of the spring combination valve core, causing the spring combination valve core to rotate around the axis. This causes the spring combination valve core to be misaligned with the top edge of the housing, thus preventing the operator from accidentally pressing the spring combination valve core when the cover is not closed. Attached Figure Description

[0018] Figure 1 This is a schematic diagram of the overall structure of the present invention; Figure 2 This is a frontal perspective view of the present invention; Figure 3 This is a top sectional view of the shell structure of the present invention; Figure 4This is a top sectional view of the arc-shaped sleeve structure of the present invention; Figure 5 for Figure 4 Enlarged view of point A in the middle; Figure 6 This is a schematic diagram of the structure of the arc-shaped sleeve end of the present invention; Figure 7 This is a front sectional view of the valve mechanism of the present invention. Figure 8 for Figure 7 Enlarged view of point B in the middle; Figure 9 This is a front cross-sectional view of the pressure storage mechanism of the present invention; Figure 10 This is a schematic diagram of the frame structure of the present invention; Figure 11 This is a schematic cross-sectional view of the piston cylinder of the present invention.

[0019] In the diagram: 1. Shell; 11. Cover; 2. Transmission mechanism; 21. Main shaft; 211. Frame; 22. Gear 1; 23. Gear 2; 3. Drive mechanism; 31. Arc-shaped sleeve; 32. Arc-shaped piston rod; 33. Spring pin 1; 34. Arc-shaped stop; 4. Accumulation mechanism; 41. Pressure pipe; 42. Piston rod; 43. One-way valve 1; 44. One-way valve 2; 45. Pipeline; 5. Valve mechanism; 51. Sleeve; 52. Spring combination valve core; 521. Spring pin 2; 53. Valve core channel 1; 54. Valve core channel 2; 6. Blood storage assembly; 61. Piston cylinder; 62. Spring piston rod; 63. One-way valve 1; 64. One-way valve 2; 65. Acrylic blood storage vessel; 66. Cap. Detailed Implementation

[0020] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0021] like Figures 1 to 11As shown, the present invention provides a pharmacokinetic-based micro-blood stratification device, including a housing 1 and a cover 11, and further including: a transmission mechanism 2 and a drive mechanism 3 installed in the housing 1, and a blood storage component 6 installed on the transmission mechanism 2; the transmission mechanism 2 includes a main shaft 21, a second gear 23 and two meshing gears 22, one of which is fixedly sleeved on the main shaft 21, and the other gear 22 and gear 23 are rotatably connected to the bottom of the housing 1 and mesh with each other, and the main shaft 21 is rotatably connected to the bottom of the housing 1; a frame 211 is fixedly connected to the top of the main shaft 21, and a plurality of blood storage components 6 are installed in a circular array on the frame 211; The drive mechanism 3 includes an arc-shaped sleeve 31 fixedly installed at the bottom of the housing 1. An arc-shaped piston rod 32 is movably sleeved inside the arc-shaped sleeve 31. Several spring latches 33 are hinged at equal angles on the arc-shaped piston rod 32. Several arc-shaped stops 34 are also provided on the arc-shaped piston rod 32 to support the corresponding spring latches 33. The spring latches 33 can be engaged in the tooth portion of the gear 23. The housing 1 is provided with a pressure accumulator 4 for pumping air into the arc-shaped sleeve 31. The housing 1 is also provided with a valve mechanism 5 for controlling the conduction of the arc-shaped sleeve 31 and the pressure accumulator 4. The minimum inner diameter of the opening at the end of the arc-shaped sleeve 31 is smaller than the outer diameter of the piston end of the arc-shaped piston rod 32. The piston end of the arc-shaped piston rod 32 is always in the arc-shaped sleeve 31. The valve mechanism 5 includes a sleeve 51 fixedly installed on the outer periphery of the housing 1. A spring combination valve core 52 is movably installed inside the sleeve 51. The top end of the spring combination valve core 52 extends to the outside of the sleeve 51. The portion of the spring combination valve core 52 located inside the sleeve 51 has a valve core channel 1 53 and a valve core channel 2 54. In the initial state, the arc-shaped sleeve 31 can communicate with the outside through the valve core channel 2 54. When the spring-loaded valve core 52 moves downward, it enables the accumulator mechanism 4 to connect with the arc-shaped sleeve 31 through the valve core channel 53. By using the above scheme, the gas in the accumulator 4 is instantly introduced into the arc-shaped sleeve 31 through the valve core channel 53 by pressing the spring combination valve core 52. This pushes the arc-shaped piston rod 32 to move the spring latch 33. The spring latch 33 on the arc-shaped piston rod 32 will then engage with the teeth of the gear 23, thereby pushing the gear 23 to rotate. Subsequently, the gear 23 will drive the main shaft 21 to rotate through two sets of gears 22, causing the blood storage component 6 to rotate at high speed with the main shaft 21. At this time, under the conditions of rapid start-up of the main shaft 21 and short-term high-speed rotation, the blood in the blood storage component 6 will be separated into layers, thus solving the problem that gravity sedimentation or extending the working time of the centrifuge will reduce the overall efficiency. During reset, the pressure on the spring combination valve core 52 is released, and the spring combination valve core 52 will move upward to reset under its own elastic force, blocking the connection between the accumulator mechanism 4 and the arc sleeve 31. At the same time, the arc sleeve 31 will be connected to the outside through the valve core channel 2 54. At this time, the arc piston rod 32 will reset under its own pulling force, thereby venting the gas in the arc sleeve 31 to the outside through the valve core channel 2 54. The spring clip 33 will also be squeezed and rotated by the teeth of the gear 2 23 and retract into the arc piston rod 32.

[0022] like Figure 7 and Figure 8 As shown, the top of the spring combination valve core 52 is hinged with a spring pin 521. One end of the spring pin 521 can extend to the top edge of the housing 1 and overlap with the top edge of the housing 1 in the vertical direction. The cover 11 can be threaded to the top of the housing 1, and when the cover 11 moves downward on the top of the housing 1, it can squeeze the spring pin 521 to rotate around the axis, thereby causing the end of the spring pin 521 to be misaligned with the edge of the top of the housing 1 in the vertical direction; By adopting the above solution, before the operator presses the spring combination valve core 52, when the operator has not covered the cover 11, the spring locking pin 521 will abut against the edge of the top of the housing 1 during the downward movement, thus preventing the spring combination valve core 52 from moving downward. When the operator covers the cover 11, the edge and outer periphery of the cover 11 will squeeze the upper surface of the spring locking pin 521, causing the spring locking pin 521 to rotate around the axis, thereby causing the spring locking pin 521 to be misaligned with the top edge of the housing 1, thus avoiding the situation where the operator accidentally presses the spring combination valve core 52 when the cover 11 is not covered.

[0023] like Figures 1-3 , Figure 7 and Figure 9 As shown, the pressure accumulator 4 includes a pressure pipe 41 fixedly installed at the bottom of the housing 1. The upper part of the pressure pipe 41 can pass through the housing 1 and the main shaft 21 and is movably sleeved in the main shaft 21. A piston rod 42 is movably sleeved on the upper part of the pressure pipe 41. A downward unidirectional one-way valve 44 is installed in the cavity of the piston rod 42. A downward unidirectional one-way valve 43 is installed in the cavity of the pressure pipe 41 and below the piston rod 42. A pipe 45 is fixedly connected to the bottom of the pressure pipe 41. The other end of the pipe 45 is fixedly installed on the outer periphery of the sleeve 51, and initially the end of the pipe 45 is blocked by the outer periphery of the spring combination valve core 52. The diameter of the top of the piston rod 42 is larger than the diameter of the bottom of the piston rod 42, and the piston rod 42 can move upward and disengage from the pressure pipe 41. Using the above scheme, when the operator presses the piston rod 42, it drives the one-way valve 44 downward, allowing the gas in the upper part of the pressure tube 41 and inside the piston rod 42 to be unidirectionally input to the bottom of the pressure tube 41 through the one-way valve 43. When the piston rod 42 moves upward, the outside gas will enter the piston rod 42 through the one-way valve 44. Repeating the above operation increases the pressure at the bottom of the pressure tube 41 cavity, realizing manual pressurization, which is convenient to use.

[0024] It is worth noting that when the cover 11 is closed, the operator needs to remove the piston rod 42 from the pressure tube 41.

[0025] like Figure 1 , Figure 2 , Figure 10 and Figure 11 As shown, a frame 211 is fixedly connected to the top of the main shaft 21, and a blood storage component 6 is inserted and installed on the frame 211. The blood storage component 6 includes a piston cylinder 61 that is vertically and movably installed on the frame 211. A spring piston rod 62 is movably installed on the piston cylinder 61. The top end of the spring piston rod 62 extends to the outside of the piston cylinder 61. A one-way valve 63 and a one-way valve 64 are installed inside the piston cylinder 61. An acrylic storage vessel 65 is fixedly connected to the piston cylinder 61. A cap 66 is installed at the other end of the acrylic storage vessel 65. The acrylic storage vessel 65 can be unidirectionally connected to the piston cylinder 61 through one-way valve 2 64, and the piston cylinder 61 cavity can be unidirectionally connected to the outside through one-way valve 1 63; the frame 211 can support the acrylic storage vessel 65, and one end of the cap 66 abuts against the frame 211. Using the above scheme, the operator removes the entire blood storage assembly 6 from the frame 211. By pressing the spring piston rod 62, the gas in the piston cylinder 61 is discharged outward through the one-way valve 63. Then, the end of the acrylic storage vessel 65 is aligned with the blood of the test subject. The pressure on the spring piston rod 62 is released, allowing it to return to its original position due to its own elasticity. At this time, the piston cylinder 61 is under negative pressure, allowing the gas in the acrylic storage vessel 65 to enter the piston cylinder 61 one-way through the one-way valve 64. The acrylic storage vessel 65 is then under negative pressure, allowing the test subject's blood to be drawn from the end of the acrylic storage vessel 65. After the blood collection is completed, the acrylic storage vessel 65 is sealed with a cap 66. When the entire blood storage assembly 6 is placed on the frame 211, the extended end of the frame 211 abuts against the cap 66, ensuring a good sealing effect on the acrylic storage vessel 65 when the device rotates at high speed.

[0026] Working principle and usage process of this invention: When the blood is stratified, the gas in the accumulator 4 is instantly introduced into the arc-shaped sleeve 31 through the valve core channel 53 by pressing the spring combination valve core 52. This pushes the arc-shaped piston rod 32 to move the spring latch 33. The spring latch 33 on the arc-shaped piston rod 32 will then engage with the teeth of the gear 23, thereby pushing the gear 23 to rotate. Subsequently, the gear 23 will drive the main shaft 21 to rotate through two sets of gears 22, and cause the blood storage component 6 to rotate at high speed with the main shaft 21. At this time, under the rapid start of the main shaft 21 and the short-term high-speed rotation, the blood in the blood storage component 6 will be stratified. When the pressure on the spring combination valve core 52 is released, it will move upward and reset under the action of its own elastic force, blocking the connection between the accumulator mechanism 4 and the arc sleeve 31. At the same time, the arc sleeve 31 will be connected to the outside through the valve core channel 2 54. At this time, it will reset under the action of its own pulling force, thereby venting the gas in the arc sleeve 31 to the outside through the valve core channel 2 54. The spring clip 33 will also be squeezed and rotated by the teeth of the gear 2 23 and retract into the arc piston rod 32. Before the operator presses the spring combination valve core 52, when the operator has not covered the cover 11, the spring latch 521 will abut against the top edge of the housing 1 during its downward movement, thus preventing the spring combination valve core 52 from moving downward. When the operator covers the cover 11, the edge and outer periphery of the cover 11 will squeeze the upper surface of the spring latch 521, causing the spring latch 521 to rotate around the axis, thereby causing the spring latch 521 to be misaligned with the top edge of the housing 1, thus preventing the operator from accidentally pressing the spring combination valve core 52 when the cover 11 is not covered.

[0027] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.

[0028] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A pharmacokinetic micro-blood fractioning device based on, comprising a housing (1) and a cover (11), characterized in that, Also include: The transmission mechanism (2) and drive mechanism (3) are installed in the shell (1), and the transmission mechanism (2) is installed with the blood storage assembly (6); The transmission mechanism (2) comprises a main shaft (21), a gear two (23) and two mutually meshing gear one (22), one of which is fixedly sleeved on the main shaft (21), and the other gear one (22) and the gear two (23) are both rotatably connected to the bottom of the shell (1) and mesh with each other, and the main shaft (21) is rotatably connected to the bottom of the shell (1); The drive mechanism (3) comprises an arc sleeve (31) fixedly installed on the bottom of the shell (1), the arc sleeve (31) movably sleeved with an arc piston rod (32), the arc piston rod (32) is equally angularly hinged with a plurality of spring pins one (33), and the arc piston rod (32) is further provided with a plurality of arc stoppers (34) for supporting the corresponding spring pins one (33), and the spring pins one (33) can be clamped into the gear two (23) tooth part; The shell (1) is provided with a pressure accumulation mechanism (4) for pumping air into the arc sleeve (31), and the shell (1) is further provided with a valve mechanism (5) for controlling the conduction of the arc sleeve (31) and the pressure accumulation mechanism (4); The top end of the main shaft (21) is fixedly connected with a frame body (211), and a plurality of blood storage assemblies (6) are annularly arranged on the frame body (211).

2. The pharmacokinetic micro-blood fractionation device of claim 1, wherein: The minimum inner diameter of the opening at the end of the arc sleeve (31) is smaller than the outer diameter of the piston end of the arc piston rod (32), and the piston end of the arc piston rod (32) is always in the arc sleeve (31).

3. The pharmacokinetic micro-blood fractionation device of claim 1, wherein: The valve mechanism (5) comprises a sleeve piece (51) fixedly installed on the outer periphery of the shell (1), a spring combined valve core (52) movably installed in the sleeve piece (51), the top end of the spring combined valve core (52) extending to the outside of the sleeve piece (51), the part of the spring combined valve core (52) in the sleeve piece (51) being provided with a valve core passage one (53) and a valve core passage two (54), and the arc sleeve (31) can be communicated with the outside through the valve core passage two (54) in the initial state; When the spring combined valve core (52) goes down, the pressure accumulation mechanism (4) can be communicated with the arc sleeve (31) through the valve core passage one (53).

4. The pharmacokinetic micro-blood fractionation device of claim 3, wherein: The top end of the spring combined valve core (52) is hinged with a spring pin two (521), one end of the spring pin two (521) can extend above the top edge of the shell (1) and have an overlapping part with the edge of the top of the shell (1) in the vertical direction; The cover body (11) can be threadedly connected with the top of the shell (1), and when the cover body (11) goes down on the top of the shell (1), it can extrude the spring pin two (521) to rotate around the shaft, so that the end of the spring pin two (521) is dislocated with the edge of the top of the shell (1) in the vertical direction.

5. The pharmacokinetic micro-blood fractionation device of claim 3, wherein: The pressure accumulating mechanism (4) comprises a pressure pipe (41) fixedly installed at the bottom of the shell (1), the upper portion of the pressure pipe (41) can pass through the shell (1) and the main shaft (21) and movably sleeved in the main shaft (21), the upper portion of the pressure pipe (41) movably sleeved with a piston rod (42), the piston rod (42) is installed with a downward one-way valve two (44) in the cavity, the pressure pipe (41) is installed with a downward one-way valve one (43) in the cavity and below the piston rod (42), the bottom of the pressure pipe (41) is fixedly communicated with a pipeline (45), the other end of the pipeline (45) is fixedly installed at the outer periphery of the sleeve piece (51), and the end of the pipeline (45) is blocked by the outer periphery of the spring combined valve core (52) at the beginning.

6. The pharmacokinetic micro-blood fractionation device of claim 5, wherein: The diameter of the top of the piston rod (42) is greater than that of the lower portion of the piston rod (42), the piston rod (42) can move upward and be separated from the pressure pipe (41).

7. The pharmacokinetic micro-blood layering device of claim 1, wherein: The top of the main shaft (21) is fixedly connected with a frame body (211), and the blood storage assembly (6) is inserted and installed on the frame body (211).

8. The pharmacokinetic micro-blood fractionation device of claim 7, wherein: The blood storage assembly (6) comprises a piston cylinder (61) movably installed on the frame body (211), the piston cylinder (61) is movably installed with a spring piston rod (62), the top end of the spring piston rod (62) extends to the outside of the piston cylinder (61), the piston cylinder (61) is installed with a one-way valve one (63) and a one-way valve two (64), the piston cylinder (61) is fixedly communicated with a acrylic blood storage pipe (65), the other end of the acrylic blood storage pipe (65) is installed with a cap (66). The acrylic blood storage pipe (65) can be one-way communicated with the piston cylinder (61) through the one-way valve two (64), and the cavity of the piston cylinder (61) can be one-way communicated with the outside through the one-way valve one (63).

9. The pharmacokinetic micro-blood fractionation device of claim 8, wherein: The frame body (211) can support the acrylic blood storage pipe (65), and one end of the cap (66) abuts against the frame body (211).

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