Semi-movable bionic false tooth

Abstract

The invention discloses a semi-movable bionic false tooth which comprises a bionic tooth, the bionic tooth is fixed on a base plate, a retainer is arranged on the periphery of the bionic tooth, a tooth root part of the bionic tooth is embedded into an alveolar cavity, the base plate is attached to an oral mucosa on the periphery of the bionic tooth, so that the bionic tooth obtains mechanical support, and the retainer is used for connecting a natural tooth and the bionic tooth. Therefore, the bionic teeth are effectively fixed. The bionic dentin is porous ceramic jointly constructed by hydroxyapatite modified by hollow aluminum-oxygen cluster porous balls and calcium silicate, hydrogel is filled in the hollow aluminum-oxygen cluster porous balls and in macroporous channels and mesoporous channels of the porous ceramic, and the components of the hydrogel are the same as those of the hydrogel of the bionic dental pulp (3). The invention can promote oral wound healing, treat or prevent oral inflammation, increase the retention ability of false teeth and reduce the absorption speed of alveolar bones, and is especially suitable for teenagers and patients with weak physique and easy infection.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of medical devices, and particularly relates to a semi-active bionic denture. BACKGROUND

[0002] Dentures, commonly known as false teeth, are commonly used in cases of tooth loss, loosening, and severe damage caused by oral diseases to replace the functions of original teeth. Currently, common dentures include active dentures, fixed dentures, and implant teeth. Active dentures have the advantages of being self-removable, easy to clean, and less burden on remaining teeth, but have the disadvantages of poor denture retention, low mastication efficiency, and poor oral hygiene that can easily cause infection. Fixed dentures use healthy teeth on both sides of the missing teeth as support to fix the denture in the oral cavity, are suitable for cases of a small number of missing teeth, intermittent missing teeth, and good health of remaining teeth, have the advantages of high mastication efficiency, comfortable wearing for patients, and little foreign body sensation. However, when installing traditional fixed dentures, part of the tooth structure of the healthy teeth on both sides of the missing teeth needs to be ground off for full crown repair.

[0003] Implant teeth are a relatively new technology that has developed rapidly in recent years. The method is to implant an implant in the alveolar bone, and then repair the tooth on the implant after the implant forms a bone bond with the alveolar bone. The advantages of implant teeth are comfortable and aesthetic use, and no damage to adjacent teeth. However, implant teeth require good overall health of the patient, sufficient height and width of the alveolar bone, and there are risks of bleeding, infection, nerve damage, perforation, and implant damage during the implant surgery process. Implant teeth are particularly unsuitable for adolescents whose oral cavities are still developing, and for elderly patients with systemic diseases such as diabetes and osteoporosis. SUMMARY

[0004] To solve the above technical problems existing in the prior art, the present application provides a semi-active bionic denture that can promote oral wound healing, treat or prevent oral inflammation, increase denture retention, and reduce alveolar bone absorption speed, and is particularly suitable for adolescents and patients who are weak and susceptible to infection.

[0005] The technical scheme adopted by the present application is as follows: A semi-active bionic denture, characterized in that it comprises a bionic tooth (4) fixed on a base (6), a retention body (5) arranged on the periphery of the bionic tooth (4), and a tooth root part of the bionic tooth (4) embedded in the alveolar bone. The base (6) is attached to the oral mucosa around the bionic tooth (4) to provide mechanical support for the bionic tooth (4). The retention body (5) is used to connect the natural tooth and the bionic tooth (4) to effectively fix the bionic tooth (4).

[0006] Furthermore, the bionic tooth (4) includes bionic enamel (1), bionic dentin (2), and bionic pulp (3); wherein the bionic dentin (2) is 3D printed based on a prosthesis model designed according to the patient's missing tooth.

[0007] Furthermore, the biomimetic dentin (2) is a porous ceramic constructed from hydroxyapatite and calcium silicate modified with hollow alumina cluster porous spheres. The porous ceramic has a rich hierarchical pore structure, including macropores with a diameter greater than 50 nm, mesopores with a diameter between 2 nm and 50 nm, and micropores with a diameter less than 2 nm. The hollow alumina cluster porous spheres and the macropores and mesopores of the porous ceramic are filled with hydrogel. The composition of the hydrogel is the same as that of the hydrogel in the biomimetic dental pulp (3).

[0008] The method for preparing the hollow aluminum oxide cluster porous spheres is as follows: a dichloromethane solution containing aluminum oxide clusters is injected into a microchannel, and deionized water is injected into another microchannel. The liquids in the two microchannels are combined into a microfluidic channel. The flow rates of the two liquids are controlled so that the oil phase (dichloromethane solution containing aluminum oxide clusters) forms droplet-like intermittent flow in the aqueous phase. The droplet-like intermittent flow moves and gradually hydrolyzes in the microfluidic channel, and finally the hollow aluminum oxide cluster porous spheres are collected at the outlet of the microfluidic channel. The diameter of the hollow aluminum oxide cluster porous spheres is in the range of 200 nm-10 μm, and the surface contains abundant pores of 0.2 nm-20 nm.

[0009] Furthermore, the biomimetic tooth enamel (1) is formed by mixing hydroxyapatite, nanodiamond, calcium silicate, epoxy resin, polyvinylidene chloride emulsion, antibacterial titanium oxide clusters, and water in a certain proportion and then curing it.

[0010] Furthermore, the mixing ratio of hydroxyapatite, nanodiamond, calcium silicate, epoxy resin, polyvinylidene chloride emulsion, antibacterial titanium dioxide cluster, and water is 100:0.2:3:3:20:4:0.5:135.

[0011] Furthermore, during the enamel curing process, the antibacterial titanium oxide clusters will surround the nanodiamonds due to electrostatic interactions, and most of the nanodiamonds will accumulate on the outer surface of the biomimetic enamel, spontaneously forming a nano-protrusion array on the enamel surface, which improves the wear resistance of the biomimetic tooth and provides a unique hydrophobic surface for the biomimetic tooth.

[0012] Furthermore, the biomimetic dental pulp (3) is a hydrogel composed of nutrient solution, interferon and gel matrix.

[0013] Furthermore, a micro-sensor can be embedded in the porous ceramic macropore channel of the biomimetic dentin (2) to monitor oral health signals, and the monitored health signals can be sent to external devices through the signal transmitter integrated in the micro-sensor.

[0014] Furthermore, the material of the retainer (5) can be a UV-curable plastic that is harmless to the human body. This material can be cured into a strong rigid resin by being irradiated with 280-360nm UV light for 10-30 minutes, thereby firmly fixing the bionic tooth and the surrounding natural teeth.

[0015] The procedure for using this invention is as follows: Before surgery, a semi-removable bionic prosthesis, 3D designed and fabricated according to the patient's wound and missing tooth, is securely assembled with the prosthesis base and retainer. The semi-removable bionic prosthesis is then placed into the extraction wound to replace the missing natural tooth. When the semi-removable bionic prosthesis needs to be replaced or removed, the fixed connection between the retainer and the natural teeth surrounding the semi-removable bionic prosthesis is opened, and the semi-removable bionic prosthesis is removed.

[0016] Compared with the prior art, the beneficial effects of the present invention are reflected in: Compared to existing types of dentures, the semi-removable bionic denture of this invention has a structure closer to natural teeth, resulting in better affinity for alveolar and oral tissue cells. Direct restoration after dental surgeries such as tooth extraction promotes wound healing. Simultaneously, the semi-removable bionic denture exhibits better wear resistance, and its unique antibacterial hydrophobic surface makes it difficult for microorganisms such as Staphylococcus aureus and Enterococcus faecalis to attach and grow, thus preventing a range of inflammations caused by oral infections to some extent. Finally, this invention allows for timely removal or replacement based on the oral development of adolescents. Attached Figure Description

[0017] Figure 1 This is a cross-sectional schematic diagram of a semi-removable bionic denture according to the present invention.

[0018] Figure 2 This is a schematic diagram of a semi-removable bionic denture combined with a base and a retainer according to the present invention.

[0019] Explanation of reference numerals in the attached diagram: 1: Bionic enamel; 2: Bionic dentin; 3: Bionic pulp; 4: Semi-removable bionic denture; 5: Retainer; 6: Denture base. Detailed Implementation

[0020] The specific embodiments of the present invention will be described in detail below with reference to the accompanying drawings. It should be understood that the specific embodiments described herein are only for illustrating and explaining the embodiments of the present invention, and are not intended to limit the embodiments of the present invention.

[0021] It should be noted that, unless otherwise specified, the embodiments and features described in the present invention can be combined with each other.

[0022] The present invention will now be described in detail with reference to the accompanying drawings and exemplary embodiments.

[0023] refer to Figure 1 and Figure 2 The present invention provides a semi-removable bionic denture, comprising a bionic tooth 4, which is fixed on a base 6. A retainer 5 is provided on the outer periphery of the bionic tooth 4. The root portion of the bionic tooth 4 is embedded in the alveolar bone. The base 6 is fitted to the oral mucosa surrounding the bionic tooth 4 to provide mechanical support for the bionic tooth 4. The retainer 5 is used to connect the natural tooth and the bionic tooth 4 to effectively fix the bionic tooth 4.

[0024] In one embodiment, the bionic tooth 4 includes bionic enamel 1, bionic dentin 2, and bionic pulp 3; wherein the bionic dentin 2 is 3D printed based on a prosthesis model designed according to the patient's missing tooth.

[0025] In one embodiment, the biomimetic dentin 2 is composed of hollow aluminum oxide clusters [Al]. 10 (CH3COO) 10 (OCH2CH3) 20 The porous ceramic, constructed from hydroxyapatite and calcium silicate modified with porous spheres, contains hydrogel inside the hollow aluminum oxide cluster porous spheres, as well as in the macropores and mesopores of the porous ceramic. The composition of the hydrogel is the same as that of the hydrogel in biomimetic dental pulp 3.

[0026] In one embodiment, the biomimetic tooth enamel 1 is composed of hydroxyapatite, nanodiamond, calcium silicate, epoxy resin, polyvinylidene chloride emulsion, and antibacterial titanium dioxide cluster [(FeI)Ti]. 11 O 14 (C3H7O) 17 It is made by mixing water in a certain proportion and then solidifying it.

[0027] In one embodiment, the biomimetic dental pulp 3 is a hydrogel composed of nutrient solution, interferon, and gel matrix.

[0028] In one embodiment, a micro-sensor can be embedded in the gap of the porous ceramic macropore channel of the biomimetic dentin 2 to monitor oral health signals, and the monitored health signals can be sent to an external device through a signal transmitter integrated in the micro-sensor.

[0029] In one embodiment, the retainer 5 may be made of a UV-curable plastic that is harmless to the human body. This material can be cured into a strong, rigid resin by irradiation with 280-360nm UV light for 10-30 minutes, thereby firmly fixing the bionic tooth and the surrounding natural teeth.

[0030] In this invention, the biomimetic dentin is made of a porous ceramic, and a feasible preparation method is to use hydroxyapatite, dicalcium silicate, tricalcium silicate, and hollow aluminum oxide clusters [Al] that have passed through a 500-mesh sieve. 10 (CH3COO) 10 (OCH2CH3) 20 Porous spherical powder and water in the following mass ratio: hydroxyapatite: dicalcium silicate: tricalcium silicate: hollow alumina clusters [Al] 10 (CH3COO) 10 (OCH2CH3) 20 Porous spheres: Water = 100: 10: 15: 1.3: 70. Mix thoroughly, add an appropriate amount of water to form a paste, and feed it into a 3D printing machine to print the denture model designed according to the patient's missing teeth. Place it in a 120~200 o Bake in an oven at temperature C for 8-48 hours to obtain biomimetic dentin porous ceramic.

[0031] In this invention, a feasible method for preparing the biomimetic tooth enamel is as follows: hydroxyapatite: layered nanodiamond: tricalcium silicate: epoxy resin: polymethacrylic acid: polyvinylidene chloride emulsion: antibacterial titanium oxide cluster [(FeI)Ti 11 O 14 (C3H7O) 17 A gel-like liquid is prepared by mixing water (100:0.2:3:3:20:4:0.5:135) and then coated or vapor-deposited onto the surface of biomimetic dentin to solidify and form biomimetic enamel.

[0032] In this invention, a feasible preparation method for the biomimetic dental pulp involves preparing a sol according to a mass ratio of nutrient solution: interferon: gel matrix = 1 : 50 : 0.1 : 60, and then heating it at 76 °C. oUnder pressure C, the sol is poured into the cavities of the biomimetic dentin, which has been cured with biomimetic enamel. After cooling to room temperature, a gel-like biomimetic pulp is formed, tightly binding the biomimetic pulp, dentin, and enamel together to form a complete semi-removable biomimetic prosthesis. The nutrient solution is composed of a variety of vitamins, minerals, amino acids, and enzymes. The interferon is preferably interferon α and interferon β, which can be purchased from MedChemExpress. The gel matrix is ​​composed of one or more compounds such as aluminum oxide clusters, calcium silicate, chitosan, collagen, polylactic acid, polyvinylpyrrolidone, hydroxyapatite, and gelatin.

[0033] Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention. Those skilled in the art can make changes, modifications, substitutions and variations to the above embodiments within the scope of the present invention.

Claims

1. A semi-removable bionic denture, characterized in that, The device includes a bionic tooth (4), which is fixed on a base (6). A retainer (5) is provided on the periphery of the bionic tooth (4). The root portion of the bionic tooth (4) is embedded in the alveolar bone. The base (6) is attached to the oral mucosa around the bionic tooth (4) to provide mechanical support for the bionic tooth (4). The retainer (5) is used to connect the natural tooth and the bionic tooth (4) so ​​that the bionic tooth (4) is effectively fixed.

2. The semi-removable bionic denture according to claim 1, characterized in that, The bionic tooth (4) includes bionic enamel (1), bionic dentin (2) and bionic pulp (3); wherein the bionic dentin (2) is 3D printed based on the denture model designed for the patient's missing tooth.

3. A semi-removable bionic denture according to claim 2, characterized in that, The biomimetic dentin (2) is a porous ceramic constructed from hydroxyapatite and calcium silicate modified with hollow alumina cluster porous spheres. The porous ceramic has a hierarchical pore structure, including macropores with a diameter greater than 50 nm, mesopores with a diameter between 2 nm and 50 nm, and micropores with a diameter less than 2 nm. The hollow alumina cluster porous spheres and the macropores and mesopores of the porous ceramic are filled with hydrogel. The composition of the hydrogel is the same as that of the hydrogel in the biomimetic dental pulp (3). The hollow aluminum oxide cluster porous spheres are prepared as follows: a dichloromethane solution containing aluminum oxide clusters is injected into a microchannel, and deionized water is injected into another microchannel. The liquids in the two microchannels are combined into a microfluidic channel. The flow rates of the two liquids are controlled so that the oil phase of the dichloromethane solution containing aluminum oxide clusters forms a droplet-like intermittent flow in the aqueous phase. The droplet-like intermittent flow moves and gradually hydrolyzes in the microfluidic channel, and finally the hollow aluminum oxide cluster porous spheres are collected at the outlet of the microfluidic channel. The diameter of the hollow aluminum oxide cluster porous spheres is in the range of 200 nm-10 μm, and the surface contains pores of 0.2 nm-20 nm.

4. A semi-removable bionic denture according to claim 2, characterized in that, The biomimetic tooth enamel (1) is made by mixing hydroxyapatite, nanodiamond, calcium silicate, epoxy resin, polyvinylidene chloride emulsion, antibacterial titanium oxide clusters, and water in a certain proportion and then curing it.

5. A semi-removable bionic denture according to claim 2, characterized in that, The mixing ratio of hydroxyapatite, nanodiamond, calcium silicate, epoxy resin, polyvinylidene chloride emulsion, antibacterial titanium dioxide cluster, and water is 100:0.2:3:3:20:4:0.5:

135.

6. A semi-removable bionic denture according to claim 2, characterized in that, During the enamel curing process, the antibacterial titanium oxide clusters will surround the nanodiamonds due to electrostatic interactions, and most of the nanodiamonds will be enriched on the outer surface of the biomimetic enamel, spontaneously forming a nano-protrusion array on the enamel surface, which improves the wear resistance of the biomimetic tooth and provides a unique hydrophobic surface for the biomimetic tooth.

7. A semi-removable bionic denture according to claim 2, characterized in that, The biomimetic dental pulp (3) is a hydrogel composed of nutrient solution, interferon and gel matrix.

8. A semi-removable bionic denture according to claim 2, characterized in that, The biomimetic dentin (2) has a porous ceramic macropore channel into which a micro-sensor can be embedded to monitor oral health signals and transmit the monitored health signals to an external device through a signal transmitter integrated in the micro-sensor.

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