Traditional Chinese medicine composition for treating abdominal mass accumulation and preparation method thereof
This traditional Chinese medicine pill, composed of twelve medicinal herbs and combined with modern pharmaceutical technology, solves the problems of single formula and unstable preparation of traditional Chinese medicine, achieving a highly efficient and safe treatment for abdominal masses, and is suitable for diseases such as breast nodules, thyroid nodules, and uterine fibroids.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-02-09
- Publication Date
- 2026-03-27
AI Technical Summary
Existing traditional Chinese medicines for treating abdominal masses have problems such as simple formulations, neglect of overall conditioning, unstable preparation processes, low bioavailability, and insufficient safety. Western medicine surgery is more invasive and has a higher risk of recurrence.
A traditional Chinese medicine composition consisting of twelve herbs, including vinegar-processed turtle shell and deer antler, is combined with modern pharmaceutical technology. Through mixing, pulverizing, starch paste binding, and hot air drying, the medicine is prepared into pills to ensure uniformity and rapid disintegration, while retaining the effective components.
It achieves multi-target, holistic treatment, significantly improving treatment efficacy, safety, and quality control, making it suitable for large-scale production, with a cure rate of over 80%.
Smart Images
Figure CN121731433A_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The present application relates to traditional Chinese medicine, in particular to a traditional Chinese medicine composition for treating accumulation of mass and a preparation method thereof. BACKGROUND
[0002] In the field of traditional Chinese medicine, accumulation of mass (such as breast nodules, thyroid nodules, uterine fibroids, liver cysts, lung nodules, etc.) is a common and frequently-occurring difficult disease. Its pathogenesis is mainly due to emotional depression, diet injury, etc., leading to liver and spleen injury, visceral disorder, qi stagnation, blood stasis, and accumulation over time. Deficiency of vital qi is the main cause of the disease.
[0003] At present, there are various clinical treatment methods for this type of disease, but there are certain limitations. Western medical treatments such as surgical resection can directly remove the lesions, but the trauma is large, and the applicability is poor for patients with multiple, diffuse lesions or those who are not tolerant to surgery, and there is a risk of recurrence. The existing traditional Chinese medicines on the market have certain limitations. Some of them have a single prescription idea, focusing on promoting blood circulation and removing blood stasis or softening and resolving nodules, often ignoring the importance of overall conditioning and supporting the body resistance, resulting in unsatisfactory curative effect. Some of them have a relatively traditional preparation process, which may lead to poor stability of drug components, low bioavailability, etc. SUMMARY
[0004] The purpose of the present application is to provide a traditional Chinese medicine compound preparation which can integrate the effects of removing blood stasis and resolving nodules, removing mass and accumulation, clearing heat and resolving toxins, and cooling blood and reducing swelling, while also considering spleen and kidney tonification and supporting vital qi, and has a mature preparation process, controllable quality, safety and effectiveness, to meet the treatment needs of the majority of patients.
[0005] Technical solution: A traditional Chinese medicine composition for treating accumulation of mass is prepared from raw medicinal materials including the following weight proportions: Vinegar turtle shell 80-90 parts, deer horn 80-90 parts, vinegar Chinese galangal 60-68 parts, turmeric 60-68 parts, angelica 120-135 parts, bran-fried atractylodes 60-68 parts, radix pseudostellariae 60-68 parts, vinegar northern prairie 60-68 parts, prunella vulgaris 80-90 parts, white peony root 120-135 parts, zhebei 80-90 parts, soap nut 80-90 parts.
[0006] Further, it is prepared from raw medicinal materials including the following weight proportions: Vinegar turtle shell 85 parts, deer horn 85 parts, vinegar Chinese galangal 64 parts, turmeric 64 parts, angelica 128 parts, bran-fried atractylodes 64 parts, radix pseudostellariae 64 parts, vinegar northern prairie 64 parts, prunella vulgaris 85 parts, white peony root 128 parts, zhebei 85 parts, soap nut 85 parts.
[0007] A preparation method of a traditional Chinese medicine composition for treating accumulation of cancerous masses, comprising the following steps: mixing and crushing the twelve raw medicinal materials into fine powder, sieving, mixing uniformly, adding a binder to make pills, and drying to obtain the traditional Chinese medicine composition.
[0008] Further, the sieving uses a 100-mesh sieve.
[0009] Further, the binder is 5%-15% starch paste.
[0010] Further, the binder is 10% starch paste.
[0011] Further, the drying uses hot air circulation drying, and the drying temperature is 50-65 DEG C.
[0012] Further, the drying temperature is 60 DEG C, and the drying time is 10-12 hours.
[0013] The application of a traditional Chinese medicine composition for treating accumulation of cancerous masses in the preparation of a medicine for treating accumulation of cancerous masses, wherein the accumulation of cancerous masses is selected from one or more of breast nodules, thyroid nodules, uterine fibroids, liver cysts and lung nodules.
[0014] Advantages: (1) The present application strictly follows the prescription principle of "monarch, minister, assistant and messenger" of traditional Chinese medicine. Vinegar turtle shell (softening and resolving nodules) and deer antler (warming kidney yang and promoting blood and reducing swelling) are used as the monarch drug, directly attacking the lesion, and jointly playing the role of resolving accumulation; Angelica, vinegar Chinese galangal, wheat bran-fried atractylodes, curcuma, and prince seng are used as the minister drug, assisting the monarch drug to enhance the effects of resolving stasis and resolving nodules, reducing blood and swelling, and at the same time, benefiting qi and invigorating the spleen, tonifying blood and promoting blood circulation, to support the healthy qi; vinegar northern bupleurum, white peony root, Zhejiang fritillary bulb, prunella vulgaris, and soapberry thorn are used as the assistant drug, assisting the monarch and minister drugs to play the roles of soothing the liver and resolving depression, clearing heat and reducing phlegm, resolving nodules and reducing swelling. The whole prescription attacks and supplements at the same time, treats the symptoms and the root cause, not only targets the "symptoms" of accumulation of cancerous masses, but also focuses on regulating the body's qi, blood, yin and yang "root", achieving the purpose of multi-target and overall treatment. The clinical application for decades and the observation data of 100 patients show that the medicine is effective for more than 96% of diseases such as breast thyroid nodules, uterine fibroids, liver cysts, lung nodules and other accumulation of cancerous masses, and the cure rate is more than 80%, with significant and stable curative effect.
[0015] (2) The application carries out systematic optimization research on the traditional pill preparation process. In view of the hard texture of animal medicines (vinegar turtle shell) and horn medicines (deer horn), the fibrous medicinal materials (schizacanthus) are not easy to be crushed, and part of the medicinal materials (angelica) is easy to soften and adhere, etc., the method of mixing and crushing twelve kinds of medicinal materials is creatively adopted. The method uses the dispersion and adsorption of powdery medicinal materials to solve the processing problem of difficult-to-crush medicinal materials and ensure the uniformity and yield of the powder. By comparing water, starch paste, dextrin and other different binders, 10% starch paste is finally determined as the binder. The choice takes into account the difficulty of pill making and the disintegration time limit of the pill, avoids the problem of slow disintegration caused by the use of refined honey or sugar solution, and ensures the rapid effect of the drug. In view of the characteristics of volatile components in medicinal materials, the mild condition of 60℃ hot air circulation drying is determined, which ensures the drying efficiency (10-12 hours) while maximally retains the effective components of the drug. The above-mentioned optimized process route is mature and stable, has good reproducibility, provides guarantee for the consistency of product quality, and is suitable for large-scale industrial production.
[0016] (3) The application is a pure traditional Chinese medicine preparation, and the components are all derived from traditional Chinese medicinal materials. After long-term clinical verification, no obvious toxic side effects and adverse reactions are found under correct guidance, the patient compliance is good, and compared with some chemical drugs or surgical therapy, it has higher safety advantage. BRIEF DESCRIPTION OF DRAWINGS
[0017] Figure 1 is a schematic diagram of the detection results of the preparation of example 2; Figures 2-10 is a clinical application situation diagram of the preparation of example 2. DETAILED DESCRIPTION
[0018] In order to make the technical scheme of the application clearer, the application will be further described in detail in combination with the drawings and specific embodiments.
[0019] The source, identification and test of the traditional Chinese medicine raw materials used in the application are shown in Table 1.
[0020] Table 1 Source, identification and test of traditional Chinese medicine raw materials The processing and processing of the traditional Chinese medicine raw materials used in the application are shown in Table 2.
[0021] Table 2 Processing and processing table of traditional Chinese medicinal materials The feeding form of the traditional Chinese medicine raw materials of the application is in the form of traditional Chinese medicine decoction pieces without special treatment.
[0022] The Chinese medicine prescription of the application is a Chinese medicinal material with more fibers. In the crushing process, the fibers are not easy to be crushed and are easy to leave residues. The vinegar turtle shell is an animal medicine, and the deer horn is a hard horn medicine, which is not easy to be crushed. If discarded, it will affect the compatibility of each component of the whole prescription. The angelica has a soft texture and is easy to soften and adhere to the crusher during the crushing process. Therefore, the whole prescription is easy to be crushed by mixing and crushing with other fine powders, and the dispersion and adsorption of other powdery medicines are used to reduce the softening and adhesion phenomenon. Therefore, the whole prescription is easy to be crushed by mixing and crushing. Through experiments, the mixing and crushing has no adverse effect on the crushing and subsequent sieving of the product. The crushing process of the product is investigated, and the results are shown in Table 3: Table 3 Crushing and sieving yield investigation table In combination with the production equipment of the preparation room, the preparation forming process of Sanjie Xiaoliu pill is studied. Generally, water pills can be prepared by using water, sugar solution and 5% or less refined honey as a binder. Considering that the use of sugar solution and refined honey to prepare water pills can easily lead to prolonged disintegration time and other defects during storage, therefore, water, 10% starch paste and 10% dextrin are respectively selected as the binder, and the production difficulty and disintegration time limit are used as the index. Each group of 200g of mixed powder of Chinese medicinal materials is weighed, and a certain amount of binder is added for the preliminary screening of the process prescription. The results are shown in Table 4: Table 4 Initial selection of binder type According to the above results, considering that dextrin can easily affect the determination of the content of traditional Chinese medicine, starch paste is initially selected as the binder.
[0023] In order to determine the final concentration of the binder, the influence of 5%, 10% and 15% concentration of starch paste on the preparation is investigated according to the principle of minimizing the amount of auxiliary materials, and the results are shown in Table 5: Table 5 Selection table of binder amount 10% starch paste is used as the binder for production.
[0024] By selecting 10% starch paste as the binder and using the plasticizing method to prepare water pills, the production efficiency is high, the appearance quality is good, and the disintegration is fast.
[0025] Since the product contains volatile components, drying treatment below 60℃ is adopted. We choose two different drying methods of drying and fluidized bed drying for drying, and the results are shown in Table 6: Table 6 Drying condition selection table Fluidized drying has the characteristics of short drying time and high efficiency, and can be used for drying production, but the cost is relatively high, and the roundness of the pellets is relatively poor. Although the drying method takes a long time, the drying method has low cost, simple equipment operation, and smooth pellet surface. Therefore, the drying method is selected as the drying method.
[0026] Example 1 Vinegar turtle shell 80 parts, deer horn 80 parts, vinegar Chinese galangal 60 parts, turmeric 60 parts, angelica 120 parts, bran-fried atractylodes 60 parts, prince salvia miltiorrhiza 60 parts, vinegar northern bupleurum 60 parts, summer grass 80 parts, white peony root 120 parts, Zhebeimu 80 parts, soapstick 80 parts.
[0027] The above twelve flavors are mixed and crushed into fine powder, sieved through a 100 mesh sieve, and mixed uniformly. 10% starch paste is used as the binder, and 5mm molds are used to make pellets. The pellets are dried at 60°C for 10-12 hours by hot air circulation drying until the moisture content is qualified. After detection, it is packaged, and the pellets are obtained.
[0028] Example 2 Vinegar turtle shell 85 parts, deer horn 85 parts, vinegar Chinese galangal 64 parts, turmeric 64 parts, angelica 128 parts, bran-fried atractylodes 64 parts, prince salvia miltiorrhiza 64 parts, vinegar northern bupleurum 64 parts, summer grass 85 parts, white peony root 128 parts, Zhebeimu 85 parts, soapstick 85 parts.
[0029] The above twelve flavors are mixed and crushed into fine powder, sieved through a 100 mesh sieve, and mixed uniformly. 10% starch paste is used as the binder, and 5mm molds are used to make pellets. The pellets are dried at 60°C for 10-12 hours by hot air circulation drying until the moisture content is qualified. After detection, it is packaged, and the pellets are obtained.
[0030] Example 3 Vinegar turtle shell 90 parts, deer horn 90 parts, vinegar Chinese galangal 68 parts, turmeric 68 parts, angelica 135 parts, bran-fried atractylodes 68 parts, prince salvia miltiorrhiza 68 parts, vinegar northern bupleurum 68 parts, summer grass 90 parts, white peony root 135 parts, Zhebeimu 90 parts, soapstick 90 parts.
[0031] The above twelve flavors are mixed and crushed into fine powder, sieved through a 100 mesh sieve, and mixed uniformly. 10% starch paste is used as the binder, and 5mm molds are used to make pellets. The pellets are dried at 60°C for 10-12 hours by hot air circulation drying until the moisture content is qualified. After detection, it is packaged, and the pellets are obtained.
[0032] Taking Example 2 as an example, 10 times the amount of the prescription is used as the raw material, and three batches of production tests are carried out according to the above process requirements. The batch numbers are 20210601, 20210602, and 20210603. The results are shown in Table 7. The results prove that the process route design is reasonable, the intermediate quality is controllable, the reproducibility is good, and it is suitable for mass production. Three batches of samples are tested according to the quality standard, and the results meet the requirements.
[0033] Table 7 Production data of three batches of samples The results of the detection of the preparation prepared in Example 2 are shown in Table 1. Figure 1
[0034] The clinical application of the preparation prepared in Example 2 is shown in Table 2. Figures 2-10
[0035] The above examples only express several embodiments of the present application, and the description is more specific and detailed, but it should not be understood as limiting the scope of the patent of the present application. It should be pointed out that for ordinary skilled in the art, without departing from the concept of the present application, several modifications and improvements can be made, which all belong to the protection scope of the present application. Therefore, the protection scope of the patent of the present application should be subject to the appended claims.
Claims
1. A traditional Chinese medicine composition for treating abdominal masses, characterized in that, Made from active pharmaceutical ingredients comprising the following parts by weight: Vinegar-processed turtle shell 80-90 parts, deer antler 80-90 parts, vinegar-processed cyperus rhizome 60-68 parts, turmeric 60-68 parts, angelica root 120-135 parts, bran-fried atractylodes macrocephala 60-68 parts, codonopsis pilosula 60-68 parts, vinegar-processed bupleurum root 60-68 parts, prunella vulgaris 80-90 parts, white peony root 120-135 parts, fritillaria thunbergii 80-90 parts, gleditsia sinensis thorns 80-90 parts.
2. The traditional Chinese medicine composition for treating abdominal masses according to claim 1, characterized in that, Made from active pharmaceutical ingredients comprising the following parts by weight: Vinegar-processed turtle shell 85 parts, deer antler 85 parts, vinegar-processed Cyperus rotundus 64 parts, turmeric 64 parts, angelica sinensis 128 parts, bran-fried Atractylodes macrocephala 64 parts, codonopsis pilosula 64 parts, vinegar-processed Bupleurum chinense 64 parts, prunella vulgaris 85 parts, white peony root 128 parts, Fritillaria thunbergii 85 parts, and Gleditsia sinensis thorns 85 parts.
3. A method for preparing a traditional Chinese medicine composition for treating abdominal masses as described in any one of claims 1 to 2, characterized in that, Includes the following steps: The twelve raw medicinal materials are mixed, pulverized into fine powder, sieved, mixed evenly, and then a binder is added to form pills. After drying, the pills are obtained.
4. The method for preparing the traditional Chinese medicine composition for treating abdominal masses according to claim 3, characterized in that, The sieving process uses a 100-mesh sieve.
5. The method for preparing the traditional Chinese medicine composition for treating abdominal masses according to claim 3, characterized in that, The adhesive is a starch paste containing 5%-15%.
6. The method for preparing the traditional Chinese medicine composition for treating abdominal masses according to claim 5, characterized in that, The adhesive is a 10% starch paste.
7. The method for preparing the traditional Chinese medicine composition for treating abdominal masses according to claim 3, characterized in that, The drying process employs hot air circulation drying at a temperature of 50℃-65℃.
8. The method for preparing the traditional Chinese medicine composition for treating abdominal masses according to claim 7, characterized in that, The drying temperature is 60℃ and the drying time is 10-12 hours.
9. The use of a traditional Chinese medicine composition for treating abdominal masses as described in any one of claims 1 to 2 in the preparation of a medicament for treating abdominal masses, characterized in that, The masses are selected from one or more of the following: breast nodules, thyroid nodules, uterine fibroids, liver cysts, and lung nodules.