Composition with soothing, anti-allergy and itching relieving effects and preparation method thereof

Abstract

The invention relates to the technical field of cosmetics, and particularly discloses a composition with soothing, anti-allergy and itching relieving effects and a preparation method thereof. According to the composition, grease, a humectant, an emulsifier and a preservative are used for constructing a basic system, and composite microgel is introduced as a core carrier. According to the composite microgel, calcium alginate gel containing magnolol nano oil drops and a paeonol clathrate compound serves as an inner core, a shell is formed by compounding sodium alginate and chitosan on an outer layer so as to wrap cardiospermum halicacabum extract lipidosome, and synergistic delivery and long-acting slow release of three active ingredients are achieved through the structure; the stability, the skin permeability and the efficacy synergy of the composition are obviously improved. The preparation technology is controllable, skin irritation can be effectively relieved, anaphylactic reaction is relieved, pruritus is relieved, and the composition is suitable for sensitive skin care.

Description

Technical Field

[0001] This invention relates to the field of cosmetic technology, and more specifically, to a composition having soothing, anti-allergic, and antipruritic effects, and a method for preparing the same. Background Technology

[0002] The number of people with sensitive skin is increasing year by year due to factors such as environmental pollution, life stress, and improper skincare habits. Sensitive skin is prone to stinging, itching, redness, tightness, and decreased barrier function when exposed to physical, chemical, or environmental stimuli. Existing soothing skincare products typically improve symptoms by adding moisturizers or anti-inflammatory ingredients, but these often rely on a single mechanism of action, such as increasing the stratum corneum's moisture content, inhibiting inflammatory factors, or forming a protective film on the surface. They are unlikely to effectively regulate multiple processes simultaneously, including nerve sensitivity, inflammation, and barrier repair. Furthermore, many natural active substances are unstable, easily oxidized, or highly irritating; direct addition of these substances often reduces product stability or affects skin tolerance.

[0003] In recent years, active delivery systems such as liposomes, nano-oil droplets, and cyclodextrin inclusion complexes have gained attention in the cosmetics field, as they can improve the dispersibility, stability, and skin absorption efficiency of active substances, thereby enhancing their actual efficacy. However, current technologies still lack the design of composite systems that synergistically apply multiple delivery systems to the field of soothing and anti-allergy, particularly in the areas of sustained release of irritating ingredients, stabilization of polyphenolic structures in plant extracts, and enhancement of skin barrier repair. How to construct a composite carrier system capable of synergistically carrying multiple different active ingredients and achieving stable coexistence, long-lasting sustained release, and targeted delivery, thereby comprehensively addressing the various problems associated with sensitive skin, remains a critical technical challenge that urgently needs to be overcome in this field. Summary of the Invention

[0004] To address the problems of stinging, itching, redness, and allergies caused by external stimuli to sensitive skin, and to overcome the shortcomings of existing technologies that rely solely on moisturizing or anti-inflammatory pathways and cannot fundamentally block nerve sensitivity, immune imbalance, and microecological disorder, this invention provides a composition with soothing, anti-allergic, and anti-itch effects, as well as its preparation method.

[0005] In a first aspect, the present invention provides a composition having soothing and anti-allergic and antipruritic effects, employing the following technical solution: A composition having soothing and anti-allergic and antipruritic effects comprises the following raw materials in weight percentage: 10-20% oil, 5-15% moisturizer, 2-4% emulsifier, 0.5-1% preservative, 3-6% complex microgel, and the balance being water; The composite microgel has a core-shell structure, with its core being a calcium alginate gel containing magnolol nano-oil droplets and paeonol inclusion complex, and its outer shell being a gel layer formed by sodium alginate and chitosan containing liposomes of lycopodium extract.

[0006] Preferably, the oil comprises evening primrose oil, grapeseed oil and squalane in a mass ratio of 1-3:1-3:5-10.

[0007] Preferably, the moisturizer comprises glycerin, betaine, sodium L-pyrrolidone-5-carboxylate, and sodium hyaluronate in a mass ratio of 10:2-4:0.5-1:0.2-0.4.

[0008] Preferably, the emulsifier comprises soybean lecithin, cetearyl alcohol, and cetearyl glucoside in a mass ratio of 1:1-3:1-3.

[0009] Preferably, the preservative comprises DL-1,2-hexanediol, p-hydroxyacetophenone, and octoxyglycerol in a mass ratio of 5-10:1:1-2.

[0010] Preferably, the magnolol nanodroplets are prepared by the following method: Honokiol, squalane, and hydrogenated lecithin were mixed and heated until dissolved. Water was then added while stirring to form a crude emulsion. The crude emulsion was subjected to high-pressure microfluidic homogenization to obtain honokiol nano-droplets.

[0011] Preferably, the mass ratio of magnolol, squalane, hydrogenated lecithin and water is 1:3-5:0.8-1.5:20-30.

[0012] Preferably, the heating temperature is 60-75℃ and the stirring speed is 150-300rpm.

[0013] Preferably, the flow rate of the added water is 0.5-2.0 mL / min.

[0014] Preferably, the high-pressure microjet homogenization process refers to transferring the sample to a microjet homogenizer and cyclically processing it 2-5 times at a pressure of 800-1200 bar.

[0015] Preferably, the magnolol nanodroplets have a particle size of 40-70 nm.

[0016] Preferably, the paeonol inclusion complex is prepared by the following method: B1. Mix hydroxypropyl-BETA-cyclodextrin with water and stir to dissolve, to obtain a hydroxypropyl-BETA-cyclodextrin solution; B2. Dissolve paeonol in anhydrous ethanol to obtain a paeonol solution; B3. Add the paeonol solution to the hydroxypropyl-BETA-cyclodextrin solution, stir until homogeneous, and freeze-dry to obtain the paeonol inclusion complex.

[0017] Preferably, in step B1, the mass ratio of hydroxypropyl-BETA-cyclodextrin to water is 1:10-15.

[0018] Preferably, in step B1, the stirring temperature is 50-60℃, the stirring speed is 400-600rpm, and the stirring time is 15-30min.

[0019] Preferably, in step B2, the mass ratio of paeonol to anhydrous ethanol is 1:20-25.

[0020] Preferably, in step B3, the mass ratio of paeonol solution to hydroxypropyl-BETA-cyclodextrin solution is 1:3-5.

[0021] Preferably, in step B3, the stirring temperature is 35-50℃, the stirring speed is 450-650rpm, and the stirring time is 40-60min.

[0022] Preferably, in step B3, freeze drying refers to freezing the system into a solid at -20 to -40°C, and then transferring it to a freeze dryer for freeze drying at a temperature of -20 to -40°C and a vacuum of 70-100 Pa for 18-24 hours.

[0023] Preferably, the *Lysimachia christinae* extract liposomes are prepared by the following method: C1. Mix hydrogenated lecithin, cholesterol and vitamin E evenly, add anhydrous ethanol, stir evenly to obtain a lipid alcohol solution; C2. Add the extract of *Lysimachia nummularia* to deionized water, stir to dissolve, filter, and obtain an aqueous solution of *Lysimachia nummularia* extract. C3. Place the aqueous solution of *Lysimachia nummularia* extract in a high-shear dispersing emulsifier, add a lipid alcohol solution while stirring, continue stirring, concentrate under reduced pressure to remove anhydrous ethanol, and obtain the colostrum. The colostrum is then homogenized under high pressure and filtered to obtain *Lysimachia nummularia* extract liposomes.

[0024] Preferably, the mass ratio of hydrogenated lecithin, cholesterol, vitamin E and anhydrous ethanol in step C1 is 8-10:2-4:1-2:40-50.

[0025] Preferably, in step C1, the stirring temperature is 45-60℃, the stirring speed is 400-600rpm, and the stirring time is 15-30min.

[0026] Preferably, in step C2, the mass ratio of *Gnaphalium affine* extract to deionized water is 1:50-60.

[0027] Preferably, in step C2, the stirring temperature is 40-50℃, the stirring speed is 200-400 rpm, and the stirring time is 30-45 min.

[0028] Preferably, filtration in step C2 refers to filtration using a microporous membrane with a diameter of 0.22-0.45 μm.

[0029] Preferably, in step C3, the mass ratio of the lipid alcohol solution to the aqueous solution of *Gnaphalium affine* extract is 1:5-7.

[0030] Preferably, in step C3, the stirring speed when adding the lipid alcohol solution is 3000-5000 rpm, and the stirring time is 20-30 min.

[0031] Preferably, the vacuum concentration conditions in step C3 include: a temperature of 40-45℃ and a vacuum degree of -0.08MPa to -0.09MPa.

[0032] Preferably, in step C3, high-pressure homogenization refers to cyclic homogenization performed 3-5 times at a temperature of 45-60℃ and a pressure of 600-800 bar.

[0033] Preferably, filtration in step C3 refers to filtration using a microporous membrane with a diameter of 0.22-0.45 μm.

[0034] Preferably, the preparation method of the composite microgel includes the following steps: A1. Mix sodium alginate and deionized water, heat and stir until completely dissolved to obtain sodium alginate solution, and divide it into the first part and the second part of sodium alginate solution according to the mass ratio of 1:2-4. A2. Mix the first sodium alginate solution with magnolol nano-oil droplets and paeonol inclusion complex to obtain a mixed solution. Dissolve calcium chloride in the mixed solvent to obtain a calcium chloride solution. Add the mixed solution to the calcium chloride solution for cross-linking. After cross-linking, perform post-processing to obtain pre-cross-linked core gel particles. A3. Mix chitosan and water evenly, adjust the pH to 4-5 with acetic acid, add the liposomes of the *Cynanchum paniculatum* extract, stir evenly to obtain a liposome dispersion; A4. Mix the pre-crosslinked core gel particles and the second sodium alginate solution, add the liposome dispersion, stir evenly to obtain a mixed system, add the mixed system to the calcium chloride aqueous solution for secondary crosslinking, after crosslinking is completed, filter, wash and freeze dry to obtain the composite microgel.

[0035] Preferably, the mass ratio of sodium alginate to deionized water in step A1 is 1:40-50.

[0036] Preferably, the heating temperature in step A1 is 50-60℃, and the stirring speed is 300-500 rpm.

[0037] Preferably, in step A2, the mass ratio of the first sodium alginate solution, magnolol nano-oil droplets, and paeonol inclusion complex is 95-105:7-9:2-3.

[0038] Preferably, the mass ratio of calcium chloride to the mixed solvent in step A2 is 1:20-30.

[0039] Preferably, the mixed solvent in step A2 is water and anhydrous ethanol in a volume ratio of 7-8:2-3.

[0040] Preferably, the mass ratio of the mixed solution to the calcium chloride solution in step A2 is 1:5-7.

[0041] Preferably, the crosslinking conditions in step A2 are: temperature of 20-35℃, stirring speed of 200-500 rpm, and stirring time of 20-40 min.

[0042] Preferably, the post-processing in step A2 refers to: centrifuging the cross-linked system at 4000-6000 rpm for 5-15 min, collecting the gel particles, washing them 2-4 times with deionized water, transferring the gel particles into a freeze dryer, and freeze-drying them for 18-24 h at a temperature of -20 to -40℃ and a vacuum of 50-100 Pa.

[0043] Preferably, in step A3, the mass ratio of chitosan, *Gnaphalium affine* extract liposomes, and water is 1:0.5-1.5:50-60.

[0044] Preferably, in step A3, the stirring temperature is 20-35℃, the stirring speed is 300-600 rpm, and the stirring time is 20-40 min.

[0045] Preferably, in step A4, the mass ratio of the pre-crosslinked core gel particles, the second sodium alginate solution, and the liposome dispersion is 1:10-20:2-4.

[0046] Preferably, in step A4, the stirring temperature is 25-35℃, the stirring speed is 400-600 rpm, and the stirring time is 10-20 min.

[0047] Preferably, the mass ratio of the mixed system to the calcium chloride aqueous solution in step A4 is 1:5-7.

[0048] Preferably, the mass fraction of calcium chloride in the calcium chloride aqueous solution in step A4 is 1-3%.

[0049] Preferably, in step A4, the temperature for secondary crosslinking is 20-35℃, the stirring speed is 200-500 rpm, and the stirring time is 20-40 min.

[0050] Preferably, filtration in step A4 refers to filtration using a microporous membrane with a diameter of 0.45-1.2 μm.

[0051] Preferably, in step A4, washing refers to washing 2-4 times with deionized water.

[0052] Preferably, in step A4, freeze drying refers to transferring the filter cake into a freeze dryer and freeze-drying it for 18-24 hours at a temperature of -20 to -40°C and a vacuum of 50-100 Pa.

[0053] Secondly, the present invention provides a method for preparing a composition having soothing, anti-allergic, and antipruritic effects, using the following technical solution: A method for preparing a composition having soothing, anti-allergic, and antipruritic effects includes the following steps: S1. Weigh out the oils, moisturizers, emulsifiers, preservatives, complex microgels, and water according to the above weight percentages, and set aside. S2. Heat water to 75-80℃, add humectant and preservative, stir to dissolve, and obtain the aqueous phase; S3. Heat the oil to 75-80℃, add the emulsifier, stir evenly, and obtain the oil phase; S4. While stirring, add the oil phase to the aqueous phase and continue stirring to form a matrix emulsion; S5. Keeping the stirring state unchanged, cool the matrix emulsion to 40-45℃, add the composite microgel, stir and disperse, adjust the pH to 5.5-6.5, and obtain the composition.

[0054] Preferably, the stirring speed in step S2 is 150-300 rpm.

[0055] Preferably, in step S3, the stirring speed is 100-250 rpm and the stirring time is 20-40 min.

[0056] Preferably, in step S4, the stirring speed is 100-250 rpm and the stirring time is 30-50 min.

[0057] Preferably, the stirring and dispersion time in step S5 is 20-40 minutes.

[0058] In summary, the present invention has the following beneficial effects: 1. This invention encapsulates active ingredients such as magnolol nanodroplets, paeonol inclusion complexes, and liposomes from *Gnaphalium affine* extract into a core-shell structured composite microgel. This structure enables the synergistic release and long-lasting effect of multiple active ingredients, thereby significantly improving the overall soothing, anti-allergic, and antipruritic effects of the product.

[0059] 2. This invention pre-treats magnolol, paeonol, and *Gnaphalium affine* extract by nano-sizing, inclusion, and liposome formation. This step effectively solves the problems of active ingredients being volatile, easily decomposed, or having low transdermal penetration in the formulation, ensuring the efficacy stability of the product during storage and use.

[0060] 3. This invention introduces a dual crosslinking approach—pre-crosslinking and secondary crosslinking—in the construction of the composite microgel, resulting in a denser and more stable structure. The secondary crosslinking process employed in this invention significantly enhances the structural integrity of the composite microgel by constructing a sodium alginate-chitosan shell on the surface of the pre-crosslinked core. This structure better resists physical shearing during formulation storage and use, ensuring its stability as an active carrier during delivery and enabling precise control of the release rate.

[0061] 4. The combination of oils and moisturizers used in this invention can effectively mimic and replenish skin lipids, enhancing the skin barrier function. Simultaneously, a gentle emulsification and preservative system is employed, and the slow-release and carrier structure of the composite microgel is introduced to ensure stable release of active ingredients and reduce direct irritation, thereby further reducing the risk of adverse reactions in sensitive skin. Overall, the safety is higher and the skin feel is gentler. Detailed Implementation

[0062] The present invention will be further described in detail below with reference to the embodiments.

[0063] For experiments not specifically described in the examples, the procedures or conditions should be followed according to the conventional experimental procedures described in the literature in this field. Reagents or instruments whose manufacturers are not specified are all commercially available conventional reagent products.

[0064] The key raw materials used in this invention are sourced from the following sources: Extract of *Heliotropium indicum*: provided by Xi'an Jincuifang Plant Technology Development Co., Ltd.; Magnolol: CAS: 528-43-8, provided by Changsha Shanghe Biotechnology Co., Ltd.; Paeonol: CAS: 552-41-0, provided by Shanghai Huayuan Century Trading Co., Ltd.; Hydroxypropyl-BETA-cyclodextrin: CAS No.: 128446-35-5, provided by Shanghai Mairui Biochemical Technology Co., Ltd.; Evening Primrose Oil: CAS No.: 90028-66-3, provided by Jiangxi Baicao Pharmaceutical Co., Ltd.; Grape seed oil: CAS No.: 8024-22-4, provided by Ji'an Wanyi Spice Oil Co., Ltd. Squalane: CAS No.: 111-01-3, provided by Wuhan Lihe Intelligent Manufacturing Biotechnology Co., Ltd.; Glycerin: CAS No.: 56-81-5, provided by Shanghai Aladdin Biochemical Technology Co., Ltd.; Betaine: CAS No.: 107-43-7, provided by Qingdao Wanyuanshan Biotechnology Co., Ltd.; Sodium L-pyrrolidone-5-carboxylate: CAS No.: 28874-51-3, provided by Shanghai Maclean Biochemical Technology Co., Ltd.; Sodium hyaluronate: CAS No.: 9067-32-7, provided by Shaanxi Yikanglong Biotechnology Co., Ltd. Soy lecithin: CAS No.: 8002-43-5, provided by Shaanxi Xintianyu Biotechnology Co., Ltd.; Hydrogenated lecithin: CAS No.: 92128-87-5, provided by Nanjing Dulai Biotechnology Co., Ltd.; Cetearyl alcohol: CAS No.: 67762-27-0, provided by Hubei Zhonglong Kangcheng Fine Chemical Co., Ltd.; Cetearyl glucoside: CAS No.: 246159-33-1, provided by Shanghai Yuanye Biotechnology Co., Ltd.; DL-1,2-Hexanediol: CAS No.: 6920-22-5, provided by Shanghai Maclean Biochemical Technology Co., Ltd. p-Hydroxyacetophenone: CAS No.: 99-93-4, provided by Shanghai Haohong Biomedical Technology Co., Ltd.; Octoxyglycerol: CAS No.: 70445-33-9, provided by Shanghai Sanmu Chemical Technology Co., Ltd.

[0065] Examples 1-3 provide a method for preparing a composition with soothing, anti-allergic and antipruritic effects.

[0066] Example 1 A composition having soothing and anti-allergic and antipruritic effects comprises the following ingredients in weight percentage: 10% oil, 15% moisturizer, 2% emulsifier, 0.5% preservative, 3% complex microgel, and the balance being water; The oils include evening primrose oil, grapeseed oil and squalane in a mass ratio of 1:1:5; The moisturizers include glycerin, betaine, sodium L-pyrrolidone-5-carboxylate, and sodium hyaluronate in a mass ratio of 10:2:0.5:0.2. The emulsifiers include soybean lecithin, cetearyl alcohol, and cetearyl glucoside in a mass ratio of 1:3:1; The preservatives include DL-1,2-hexanediol, p-hydroxyacetophenone, and octoxyglycerol in a mass ratio of 5:1:2; Magnolol nano-droplets were prepared by the following method: The mass ratio of magnolol, squalane, hydrogenated lecithin, and water was controlled at 1:3:1.5:20. The magnolol, squalane, and hydrogenated lecithin were mixed evenly and heated at 60°C until completely dissolved. Then, water was added at a speed of 150 rpm and a flow rate of 0.5 mL / min to form a crude emulsion. The crude emulsion was transferred to a microfluidic homogenizer and circulated 5 times at a pressure of 800 bar to obtain magnolol nano-oil droplets with a particle size of 40 nm. Paeonol inclusion complex was prepared by the following method: B1. Control the mass ratio of hydroxypropyl-BETA-cyclodextrin to water to be 1:10. Mix hydroxypropyl-BETA-cyclodextrin and water and stir for 30 minutes at 50℃ and 400 rpm to obtain a hydroxypropyl-BETA-cyclodextrin solution. B2. Control the mass ratio of paeonol and anhydrous ethanol to 1:20, dissolve paeonol in anhydrous ethanol to obtain paeonol solution; B3. Controlling the mass ratio of paeonol solution and hydroxypropyl-BETA-cyclodextrin solution to 1:3, add paeonol solution to hydroxypropyl-BETA-cyclodextrin solution, stir for 60 min at 35℃ and 450 rpm, freeze the system into a solid at -20℃, and then transfer it to a freeze dryer for freeze drying at -20℃ and 70 Pa for 24 h to obtain paeonol inclusion complex. Liposomes of *Heliotropium indicum* extract were prepared by the following method: C1. Control the mass ratio of hydrogenated lecithin, cholesterol, vitamin E and anhydrous ethanol to 8:2:1:40. Mix hydrogenated lecithin, cholesterol and vitamin E evenly, add anhydrous ethanol, and stir for 30 minutes at 45℃ and 400 rpm to obtain a lipid alcohol solution. C2. Control the mass ratio of *Lysimachia nummularia* extract to water to be 1:50. Add *Lysimachia nummularia* extract to deionized water and stir for 45 minutes at 40℃ and 200 rpm. Filter through a 0.22 μm microporous membrane to obtain an aqueous solution of *Lysimachia nummularia* extract. C3. The mass ratio of lipid alcohol solution to *Lysimachia nummularia* extract aqueous solution was controlled at 1:5. The *Lysimachia nummularia* extract aqueous solution was placed in a high-shear dispersing emulsifier, and the lipid alcohol solution was added at a stirring speed of 3000 rpm. The stirring was continued for 30 min. After concentrating and removing anhydrous ethanol under the conditions of 40℃ and vacuum degree of -0.08 MPa, the pre-emulsion was obtained. The pre-emulsion was homogenized 5 times under the conditions of 45℃ and pressure of 600 bar. After filtration through a 0.22 μm microporous membrane, *Lysimachia nummularia* extract liposomes were obtained. The preparation method of composite microgels includes the following steps: A1. Control the mass ratio of sodium alginate and deionized water to 1:40. Mix sodium alginate and deionized water and stir at 50℃ and 300rpm until completely dissolved to obtain sodium alginate solution. Divide the solution into a first sodium alginate solution and a second sodium alginate solution at a mass ratio of 1:2. A2. Control the mass ratio of the first sodium alginate solution, magnolol nano-droplets, and paeonol inclusion complex to 95:9:2. Mix the first sodium alginate solution with magnolol nano-droplets and paeonol inclusion complex evenly to obtain a mixed solution. Control the mass ratio of calcium chloride to mixed solvent to 1:20. Dissolve calcium chloride in mixed solvent (volume ratio of water and anhydrous ethanol 7:3) to obtain a calcium chloride solution. Control the mass ratio of the mixed solution to calcium chloride solution to 1:5. Add the mixed solution to the calcium chloride solution and crosslink at 20℃ and 250 rpm for 40 min. After crosslinking, centrifuge at 4000 rpm for 15 min, collect the gel particles, wash twice with deionized water, transfer the gel particles to a freeze dryer, and freeze-dry at -20℃ and 50 Pa for 24 h to obtain pre-crosslinked core gel particles. A3. Control the mass ratio of chitosan, lysimachia extract liposomes and water to 1:1.5:50. Mix chitosan and water evenly, adjust the pH to 4 with acetic acid, add lysimachia extract liposomes, and stir for 40 minutes at 20℃ and 300 rpm to obtain liposome dispersion. A4. Controlling the mass ratio of pre-crosslinked core gel particles, the second sodium alginate solution, and the liposome dispersion to 1:20:2, the pre-crosslinked core gel particles and the second sodium alginate solution were mixed, and the liposome dispersion was added. The mixture was stirred for 20 minutes at 25℃ and 400 rpm to obtain a mixed system. Controlling the mass ratio of the mixed system to the calcium chloride aqueous solution to 1:5, the mixed system was added to a 1% calcium chloride aqueous solution. Secondary crosslinking was carried out at 20℃ and 250 rpm. After crosslinking, the mixture was filtered using a 0.45 μm microporous membrane. The filter cake was washed twice with deionized water and transferred to a freeze dryer. The filter cake was freeze-dried for 24 hours at -20℃ and 50 Pa to obtain the composite microgel. A method for preparing a composition having soothing, anti-allergic, and antipruritic effects includes the following steps: S1. Weigh out the oils, moisturizers, emulsifiers, preservatives, complex microgels, and water according to the above weight percentages, and set aside. S2. Heat water to 75°C, add humectant and preservative, and stir at 150 rpm until completely dissolved to obtain the aqueous phase; S3. Heat the oil to 75°C, add the emulsifier, and stir at 100 rpm for 40 minutes to obtain the oil phase; S4. While stirring, add the oil phase to the aqueous phase at 100 rpm and continue stirring for 50 minutes to form a matrix emulsion. S5. Keeping the stirring state unchanged, cool the matrix emulsion to 40°C, add the composite microgel, stir and disperse for 20 minutes, adjust the pH to 5.5, and obtain the composition.

[0067] Example 2 A composition having soothing and anti-allergic and antipruritic effects comprises the following ingredients in weight percentage: 15% oil, 11% moisturizer, 3% emulsifier, 0.7% preservative, 4.5% complex microgel, and the balance being water; The oils include evening primrose oil, grapeseed oil and squalane in a mass ratio of 2:2:7; The moisturizers include glycerin, betaine, sodium L-pyrrolidone-5-carboxylate, and sodium hyaluronate in a mass ratio of 10:3:0.7:0.3; The emulsifiers include soybean lecithin, cetearyl alcohol, and cetearyl glucoside in a mass ratio of 1:2:2; The preservatives include DL-1,2-hexanediol, p-hydroxyacetophenone, and octoxyglycerol in a mass ratio of 7:1:1.6; Magnolol nano-droplets were prepared by the following method: The mass ratio of magnolol, squalane, hydrogenated lecithin and water was controlled at 1:4:1.2:25. The magnolol, squalane and hydrogenated lecithin were mixed evenly and heated at 68℃ until completely dissolved. Then, water was added at a flow rate of 1 mL / min at a speed of 220 rpm to form a crude emulsion. The crude emulsion was transferred to a microfluidic homogenizer and circulated three times at a pressure of 1000 bar to obtain magnolol nano-oil droplets with a particle size of 55 nm. Paeonol inclusion complex was prepared by the following method: B1. Control the mass ratio of hydroxypropyl-BETA-cyclodextrin to water to be 1:12. Mix hydroxypropyl-BETA-cyclodextrin and water and stir for 25 minutes at a temperature of 54℃ and a speed of 480rpm to obtain a hydroxypropyl-BETA-cyclodextrin solution. B2. Control the mass ratio of paeonol and anhydrous ethanol to 1:22, dissolve paeonol in anhydrous ethanol to obtain a paeonol solution; B3. Controlling the mass ratio of paeonol solution and hydroxypropyl-BETA-cyclodextrin solution to 1:4, add paeonol solution to hydroxypropyl-BETA-cyclodextrin solution, stir for 50 min at 45℃ and 550 rpm, freeze the system into a solid at -30℃, then transfer it to a freeze dryer and freeze dry for 20 h at -30℃ and 85 Pa to obtain paeonol inclusion complex; Liposomes of *Heliotropium indicum* extract were prepared by the following method: C1. Control the mass ratio of hydrogenated lecithin, cholesterol, vitamin E and anhydrous ethanol to 9:3:1.5:45. Mix hydrogenated lecithin, cholesterol and vitamin E evenly, add anhydrous ethanol, and stir for 20 minutes at 55℃ and 500 rpm to obtain a lipid alcohol solution. C2. Control the mass ratio of *Lysimachia nummularia* extract to water to be 1:55. Add *Lysimachia nummularia* extract to deionized water and stir for 40 min at 44℃ and 300 rpm. Filter through a 0.35 μm microporous membrane to obtain an aqueous solution of *Lysimachia nummularia* extract. C3. The mass ratio of lipid alcohol solution to *Lysimachia nummularia* extract aqueous solution was controlled at 1:6. The *Lysimachia nummularia* extract aqueous solution was placed in a high-shear dispersing emulsifier, and the lipid alcohol solution was added at a stirring speed of 4000 rpm. The stirring was continued for 25 min. After concentrating and removing anhydrous ethanol under the conditions of 42℃ and vacuum degree of -0.08 MPa, the pre-emulsion was obtained. The pre-emulsion was homogenized 4 times under the conditions of 55℃ and pressure of 700 bar. After filtration through a 0.35 μm microporous membrane, *Lysimachia nummularia* extract liposomes were obtained. The preparation method of composite microgels includes the following steps: A1. Control the mass ratio of sodium alginate and deionized water to 1:45. Mix sodium alginate and deionized water and stir at 55℃ and 400rpm until completely dissolved to obtain sodium alginate solution. Divide the solution into a first part and a second part of sodium alginate solution at a mass ratio of 1:3. A2. Control the mass ratio of the first sodium alginate solution, magnolol nano-droplets, and paeonol inclusion complex to 100:8:2.5. Mix the first sodium alginate solution with magnolol nano-droplets and paeonol inclusion complex evenly to obtain a mixed solution. Control the mass ratio of calcium chloride to mixed solvent to 1:25. Dissolve calcium chloride in mixed solvent (volume ratio of water and anhydrous ethanol 8:2) to obtain a calcium chloride solution. Control the mass ratio of the mixed solution to calcium chloride solution to 1:6. Add the mixed solution to the calcium chloride solution and crosslink at 30℃ and 300 rpm for 30 min. After crosslinking, centrifuge at 5000 rpm for 10 min, collect the gel particles, wash with deionized water 4 times, transfer the gel particles to a freeze dryer, and freeze-dry at -30℃ and 70 Pa for 20 h to obtain pre-crosslinked core gel particles. A3. Control the mass ratio of chitosan, *Gnaphalium affine* extract liposomes and water to 1:1:55. Mix chitosan and water evenly, adjust the pH to 4.5 with acetic acid, add *Gnaphalium affine* extract liposomes, and stir for 30 minutes at 30℃ and 500 rpm to obtain liposome dispersion. A4. Controlling the mass ratio of pre-crosslinked core gel particles, the second sodium alginate solution, and the liposome dispersion to 1:15:3, the pre-crosslinked core gel particles and the second sodium alginate solution were mixed, and the liposome dispersion was added. The mixture was stirred for 15 minutes at 30℃ and 500 rpm to obtain a mixed system. Controlling the mass ratio of the mixed system to the calcium chloride aqueous solution to 1:6, the mixed system was added to a 2% calcium chloride aqueous solution. Secondary crosslinking was carried out at 30℃ and 400 rpm. After crosslinking, the mixture was filtered using a 0.7 μm microporous membrane. The filter cake was washed three times with deionized water and transferred to a freeze dryer. The filter cake was freeze-dried at -30℃ and 70 Pa for 20 hours to obtain the composite microgel. A method for preparing a composition having soothing, anti-allergic, and antipruritic effects includes the following steps: S1. Weigh out the oils, moisturizers, emulsifiers, preservatives, complex microgels, and water according to the above weight percentages, and set aside. S2. Heat water to 77°C, add humectant and preservative, and stir at 250 rpm until completely dissolved to obtain the aqueous phase; S3. Heat the oil to 77°C, add the emulsifier, and stir at 200 rpm for 30 minutes to obtain the oil phase; S4. While stirring, add the oil phase to the aqueous phase at a speed of 200 rpm and continue stirring for 40 minutes to form a matrix emulsion. S5. Keeping the stirring state unchanged, cool the matrix emulsion to 42°C, add the composite microgel, stir and disperse for 30 minutes, adjust the pH to 6.5, and obtain the composition.

[0068] Example 3 A composition having soothing and anti-allergic and antipruritic effects comprises the following ingredients by weight percentage: 20% oil, 7% moisturizer, 4% emulsifier, 0.9% preservative, 6% complex microgel, and the balance being water; The oils include evening primrose oil, grapeseed oil and squalane in a mass ratio of 3:3:10; The moisturizers include glycerin, betaine, sodium L-pyrrolidone-5-carboxylate, and sodium hyaluronate in a mass ratio of 10:4:1:0.4. The emulsifiers include soybean lecithin, cetearyl alcohol, and cetearyl glucoside in a mass ratio of 1:1:3; The preservatives include DL-1,2-hexanediol, p-hydroxyacetophenone, and octoxyglycerol in a mass ratio of 10:1:2; Magnolol nano-droplets were prepared by the following method: The mass ratio of magnolol, squalane, hydrogenated lecithin and water was controlled at 1:5:0.8:30. The magnolol, squalane and hydrogenated lecithin were mixed evenly and heated at 75°C until completely dissolved. Then water was added at a flow rate of 2 mL / min at a speed of 300 rpm to form a crude emulsion. The crude emulsion was transferred to a microfluidic homogenizer and circulated twice at a pressure of 1200 bar to obtain magnolol nano-oil droplets with a particle size of 65 nm. Paeonol inclusion complex was prepared by the following method: B1. Control the mass ratio of hydroxypropyl-BETA-cyclodextrin to water to be 1:15. Mix hydroxypropyl-BETA-cyclodextrin and water and stir for 15 minutes at 60℃ and 600 rpm to obtain a hydroxypropyl-BETA-cyclodextrin solution. B2. Control the mass ratio of paeonol and anhydrous ethanol to 1:25, dissolve paeonol in anhydrous ethanol to obtain paeonol solution; B3. Controlling the mass ratio of paeonol solution and hydroxypropyl-BETA-cyclodextrin solution to 1:5, add paeonol solution to hydroxypropyl-BETA-cyclodextrin solution, stir for 40 min at 50℃ and 650 rpm, freeze the system into a solid at -40℃, and then transfer it to a freeze dryer for freeze drying at -40℃ and 100 Pa for 18 h to obtain paeonol inclusion complex. Liposomes of *Heliotropium indicum* extract were prepared by the following method: C1. Control the mass ratio of hydrogenated lecithin, cholesterol, vitamin E and anhydrous ethanol to 10:4:1:50. Mix hydrogenated lecithin, cholesterol and vitamin E evenly, add anhydrous ethanol, and stir for 15 minutes at 60℃ and 600 rpm to obtain a lipid alcohol solution. C2. Control the mass ratio of *Lysimachia nummularia* extract to water to be 1:60. Add *Lysimachia nummularia* extract to deionized water and stir for 30 minutes at 50℃ and 450 rpm. Filter through a 0.45 μm microporous membrane to obtain an aqueous solution of *Lysimachia nummularia* extract. C3. The mass ratio of lipid alcohol solution to *Lysimachia nummularia* extract aqueous solution was controlled at 1:7. The *Lysimachia nummularia* extract aqueous solution was placed in a high-shear dispersing emulsifier, and the lipid alcohol solution was added at a stirring speed of 5000 rpm. The stirring was continued for 20 min. After concentrating and removing anhydrous ethanol under the conditions of 45℃ and vacuum degree of -0.09 MPa, the pre-emulsion was obtained. The pre-emulsion was homogenized three times under the conditions of 60℃ and pressure of 800 bar. After filtration through a 0.45 μm microporous membrane, *Lysimachia nummularia* extract liposomes were obtained. The preparation method of composite microgels includes the following steps: A1. Control the mass ratio of sodium alginate and deionized water to 1:50. Mix sodium alginate and deionized water and stir at 60℃ and 500rpm until completely dissolved to obtain sodium alginate solution. Divide the solution into a first sodium alginate solution and a second sodium alginate solution at a mass ratio of 1:5. A2. Control the mass ratio of the first sodium alginate solution, magnolol nano-droplets, and paeonol inclusion complex to 105:7:3. Mix the first sodium alginate solution with magnolol nano-droplets and paeonol inclusion complex evenly to obtain a mixed solution. Control the mass ratio of calcium chloride to mixed solvent to 1:30. Dissolve calcium chloride in mixed solvent (volume ratio of water and anhydrous ethanol 7:2) to obtain a calcium chloride solution. Control the mass ratio of the mixed solution to calcium chloride solution to 1:7. Add the mixed solution to the calcium chloride solution and crosslink at 35℃ and 450 rpm for 20 min. After crosslinking, centrifuge at 5500 rpm for 5 min, collect the gel particles, wash with deionized water 3 times, transfer the gel particles to a freeze dryer, and freeze-dry at -40℃ and 100 Pa for 18 h to obtain pre-crosslinked core gel particles. A3. Control the mass ratio of chitosan, lysimachia extract liposomes and water to 1:0.5:60. Mix chitosan and water evenly, adjust the pH to 5 with acetic acid, add lysimachia extract liposomes, and stir for 25 minutes at 35℃ and 550 rpm to obtain liposome dispersion. A4. Controlling the mass ratio of pre-crosslinked core gel particles, the second sodium alginate solution, and the liposome dispersion to 1:10:4, the pre-crosslinked core gel particles and the second sodium alginate solution were mixed, and the liposome dispersion was added. The mixture was stirred for 10 min at 35℃ and 600 rpm to obtain a mixed system. Controlling the mass ratio of the mixed system to the calcium chloride aqueous solution to 1:7, the mixed system was added to a 3% calcium chloride aqueous solution. Secondary crosslinking was carried out at 35℃ and 500 rpm. After crosslinking, the mixture was filtered using a 1.0 μm microporous membrane. The filter cake was washed three times with deionized water and transferred to a freeze dryer. The filter cake was freeze-dried at -40℃ and 100 Pa for 18 h to obtain the composite microgel. A method for preparing a composition having soothing, anti-allergic, and antipruritic effects includes the following steps: S1. Weigh out the oils, moisturizers, emulsifiers, preservatives, complex microgels, and water according to the above weight percentages, and set aside. S2. Heat water to 80°C, add humectant and preservative, and stir at 300 rpm until completely dissolved to obtain the aqueous phase; S3. Heat the oil to 80°C, add the emulsifier, and stir at 250 rpm for 20 minutes to obtain the oil phase; S4. While stirring, add the oil phase to the aqueous phase at a speed of 250 rpm for 30 minutes to form a matrix emulsion. S5. Keeping the stirring state unchanged, cool the matrix emulsion to 45°C, add the composite microgel, stir and disperse for 20 minutes, adjust the pH to 6.5, and obtain the composition.

[0069] To verify the comprehensive performance of the compositions with soothing, anti-allergic, and antipruritic effects prepared in Examples 1-3 of this invention, the inventors set up Comparative Examples 1-7, as follows: Comparative Example 1 The difference between this comparative example and Example 1 is that no composite microgel is prepared. Instead, magnolol nano-oil droplets, paeonol inclusion complex, and liposomes of *Gnaphalium affine* extract are directly added to the matrix emulsion. The total amount of active ingredients added is equivalent to the total amount introduced by the composite microgel in Example 1. The remaining steps and raw materials are the same as in Example 1. A composition having soothing and anti-allergic and antipruritic effects comprises the following ingredients in weight percentage: 10% oil, 15% moisturizer, 2% emulsifier, 0.5% preservative, 1.25% magnolol nano oil droplets, 1.25% *Gnaphalium affine* extract liposomes, 0.5% paeonol inclusion complex, and the balance being water; A method for preparing a composition having soothing, anti-allergic, and antipruritic effects includes the following steps: S1. Weigh out the oil, moisturizer, emulsifier, preservative, magnolol nano-oil droplets, paeonol inclusion complex, lipolytica extract liposomes and water according to the above weight percentages, and set aside. S2. Heat water to 75°C, add humectant and preservative, and stir at 150 rpm until completely dissolved to obtain the aqueous phase; S3. Heat the oil to 75°C, add the emulsifier, and stir at 100 rpm for 40 minutes to obtain the oil phase; S4. While stirring, add the oil phase to the aqueous phase at 100 rpm and continue stirring for 50 minutes to form a matrix emulsion. S5. Keeping the stirring state unchanged, cool the matrix emulsion to 40°C, add magnolol nano-oil droplets, paeonol inclusion complex and liposomes of calamus extract in sequence, stir and disperse for 20 min, adjust the pH to 5.5, and obtain the composition.

[0070] Comparative Example 2 The difference between this comparative example and Example 1 is that, in the preparation of the composite microgel, no two cross-linking processes are performed, while the remaining steps and raw materials are the same as in Example 1. The preparation method of composite microgels includes the following steps: A1. Control the mass ratio of sodium alginate and deionized water to 1:40. Mix sodium alginate and deionized water and stir at 50℃ and 300rpm until completely dissolved to obtain sodium alginate solution. A2. The mass ratio of sodium alginate solution, magnolol nano-droplets, paeonol inclusion complex, and *Lysimachia christinae* extract liposomes was controlled at 100:9:2:9. The sodium alginate solution was mixed evenly with the magnolol nano-droplets, paeonol inclusion complex, and *Lysimachia christinae* extract liposomes to obtain a mixed solution. The mass ratio of calcium chloride to the mixed solvent was controlled at 1:20. Calcium chloride was dissolved in the mixed solvent (water and anhydrous ethanol volume ratio 7:3) to obtain a calcium chloride solution. The mass ratio of the mixed solution to the calcium chloride solution was controlled at 1:5. The mixed solution was added to the calcium chloride solution, and crosslinking was carried out at 20℃ and 250 rpm for 40 min. After crosslinking, the mixture was centrifuged at 4000 rpm for 15 min, and the gel particles were collected. The gel particles were washed twice with deionized water and transferred to a freeze dryer. The mixture was freeze-dried at -20℃ and 50 Pa for 24 h to obtain a composite microgel.

[0071] Comparative Example 3 The difference between this comparative example and Example 1 is that, in the preparation of the composite microgel, the liposomes of the *Lysimachia christinae* extract were mixed with the first sodium alginate solution, and the magnolol nano-oil droplets and paeonol inclusion complex were mixed with chitosan. The remaining steps and raw materials were the same as in Example 1. The preparation method of composite microgels includes the following steps: A1. Control the mass ratio of sodium alginate and deionized water to 1:40. Mix sodium alginate and deionized water and stir at 50℃ and 300rpm until completely dissolved to obtain sodium alginate solution. Divide the solution into a first sodium alginate solution and a second sodium alginate solution at a mass ratio of 1:2. A2. Control the mass ratio of the first sodium alginate solution and the liposomes of *Gnaphalium affine* extract to 95:11. Mix the first sodium alginate solution and the liposomes of *Gnaphalium affine* extract evenly to obtain a mixture. Control the mass ratio of calcium chloride to the mixed solvent to 1:20. Dissolve calcium chloride in the mixed solvent (volume ratio of water to anhydrous ethanol 7:3) to obtain a calcium chloride solution. Control the mass ratio of the mixture to the calcium chloride solution to 1:5. Add the mixture to the calcium chloride solution and crosslink at 20℃ and 250 rpm for 40 min. After crosslinking, centrifuge at 4000 rpm for 15 min, collect the gel particles, wash twice with deionized water, transfer the gel particles to a freeze dryer, and freeze-dry at -20℃ and 50 Pa for 24 h to obtain pre-crosslinked core gel particles. A3. Control the mass ratio of chitosan, magnolol nano-oil droplets and paeonol inclusion complex to water to 1:1.4:0.1:50. Mix chitosan and water evenly, adjust the pH to 4 with acetic acid, add magnolol nano-oil droplets and paeonol inclusion complex, and stir for 40 minutes at 20℃ and 300 rpm to obtain a dispersion. A4. Controlling the mass ratio of pre-crosslinked core gel particles, the second sodium alginate solution, and the dispersion to 1:20:2, mix the pre-crosslinked core gel particles and the second sodium alginate solution, add the dispersion, and stir for 20 min at 25℃ and 400 rpm to obtain a mixed system. Controlling the mass ratio of the mixed system and the calcium chloride aqueous solution to 1:5, add the mixed system to a 1% (w / w) calcium chloride aqueous solution, and perform secondary crosslinking at 20℃ and 250 rpm. After crosslinking, filter using a 0.45 μm microporous membrane, wash the filter cake twice with deionized water, transfer the filter cake to a freeze dryer, and freeze-dry for 24 h at -20℃ and 50 Pa to obtain the composite microgel.

[0072] Comparative Example 4 The difference between this comparative example and Example 1 is that paeonol, magnolol, and daffodil extract were not pretreated, while the remaining steps and raw materials were the same as in Example 1. The preparation method of composite microgels includes the following steps: A1. Control the mass ratio of sodium alginate and deionized water to 1:40. Mix sodium alginate and deionized water and stir at 50℃ and 300rpm until completely dissolved to obtain sodium alginate solution. Divide the solution into a first sodium alginate solution and a second sodium alginate solution at a mass ratio of 1:2. A2. Control the mass ratio of the first sodium alginate solution, magnolol, and paeonol to 95:9:2. Mix the first sodium alginate solution with magnolol and paeonol evenly to obtain a mixed solution. Control the mass ratio of calcium chloride to the mixed solvent to 1:20. Dissolve calcium chloride in the mixed solvent (volume ratio of water and anhydrous ethanol 7:3) to obtain a calcium chloride solution. Control the mass ratio of the mixed solution to the calcium chloride solution to 1:5. Add the mixed solution to the calcium chloride solution and crosslink at 20℃ and 250 rpm for 40 min. After crosslinking, centrifuge at 4000 rpm for 15 min, collect the gel particles, wash twice with deionized water, transfer the gel particles to a freeze dryer, and freeze-dry at -20℃ and 50 Pa for 24 h to obtain pre-crosslinked core gel particles. A3. Control the mass ratio of chitosan, *Gnaphalium affine* extract and water to 1:1.5:50. Mix chitosan and water evenly, adjust the pH to 4 with acetic acid, add *Gnaphalium affine* extract, and stir for 40 minutes at 20℃ and 300 rpm to obtain a dispersion. A4. Controlling the mass ratio of pre-crosslinked core gel particles, the second sodium alginate solution, and the dispersion to 1:20:2, mix the pre-crosslinked core gel particles and the second sodium alginate solution, add the dispersion, and stir for 20 min at 25℃ and 400 rpm to obtain a mixed system. Controlling the mass ratio of the mixed system and the calcium chloride aqueous solution to 1:5, add the mixed system to a 1% (w / w) calcium chloride aqueous solution, and perform secondary crosslinking at 20℃ and 250 rpm. After crosslinking, filter using a 0.45 μm microporous membrane, wash the filter cake twice with deionized water, transfer the filter cake to a freeze dryer, and freeze-dry for 24 h at -20℃ and 50 Pa to obtain the composite microgel.

[0073] Comparative Example 5 The difference between this comparative example and Example 1 is that in the original step A2, the mass of magnolol nano-oil droplets was replaced with paeonol inclusion complex, while the remaining steps and raw materials were the same as in Example 1. A2. Control the mass ratio of the first sodium alginate solution and the paeonol inclusion complex to be 95:11. Mix the first sodium alginate solution and the paeonol inclusion complex evenly to obtain a mixed solution. Control the mass ratio of calcium chloride and the mixed solvent to be 1:20. Dissolve the calcium chloride in the mixed solvent (volume ratio of water and anhydrous ethanol 7:3) to obtain a calcium chloride solution. Control the mass ratio of the mixed solution and the calcium chloride solution to be 1:5. Add the mixed solution to the calcium chloride solution and crosslink at 20℃ and 250 rpm for 40 min. After crosslinking, centrifuge at 4000 rpm for 15 min, collect the gel particles, wash twice with deionized water, transfer the gel particles to a freeze dryer, and freeze-dry at -20℃ and 50 Pa for 24 h to obtain pre-crosslinked core gel particles.

[0074] Comparative Example 6 The difference between this comparative example and Example 1 is that in the original step A2, the paeonol inclusion complex was replaced with magnolol nano-oil droplets of equal mass, while the remaining steps and raw materials were the same as in Example 1. A2. Control the mass ratio of the first sodium alginate solution to magnolol nano-oil droplets to 95:11. Mix the first sodium alginate solution and magnolol nano-oil droplets evenly to obtain a mixed solution. Control the mass ratio of calcium chloride to the mixed solvent to 1:20. Dissolve calcium chloride in the mixed solvent (volume ratio of water to anhydrous ethanol 7:3) to obtain a calcium chloride solution. Control the mass ratio of the mixed solution to the calcium chloride solution to 1:5. Add the mixed solution to the calcium chloride solution and crosslink at 20℃ and 250 rpm for 40 min. After crosslinking, centrifuge at 4000 rpm for 15 min, collect the gel particles, wash twice with deionized water, transfer the gel particles to a freeze dryer, and freeze-dry at -20℃ and 50 Pa for 24 h to obtain pre-crosslinked core gel particles.

[0075] Comparative Example 7 The difference between this comparative example and Example 1 is that, in the original step A3, the liposomes of the *Lysimachia nummularia* extract were not added, while the remaining steps and raw materials were the same as in Example 1. A3. Control the mass ratio of chitosan to water to 1:50, mix chitosan and water evenly, adjust the pH to 4 with acetic acid to obtain a dispersion; A4. Controlling the mass ratio of pre-crosslinked core gel particles, the second sodium alginate solution, and the dispersion to 1:20:2, mix the pre-crosslinked core gel particles and the second sodium alginate solution, add the dispersion, and stir for 20 min at 25℃ and 400 rpm to obtain a mixed system. Controlling the mass ratio of the mixed system and the calcium chloride aqueous solution to 1:5, add the mixed system to a 1% (w / w) calcium chloride aqueous solution, and perform secondary crosslinking at 20℃ and 250 rpm. After crosslinking, filter using a 0.45 μm microporous membrane, wash the filter cake twice with deionized water, transfer the filter cake to a freeze dryer, and freeze-dry for 24 h at -20℃ and 50 Pa to obtain the composite microgel.

[0076] The overall performance of the compositions with soothing, anti-allergic and antipruritic effects prepared in Examples 1-3 and Comparative Examples 1-7 of the present invention was tested respectively.

[0077] 1. Stimulation test The compositions with soothing, anti-allergic, and antipruritic effects prepared in Examples 1-3 and Comparative Examples 1-7 of this invention were used as test samples. A patch test was used to verify the irritant properties of these compositions. Specifically, approximately 0.02 g of each composition obtained in Examples 1-3 and Comparative Examples 1-7 was placed in the chamber of a standard patch applicator and applied to the inner forearm of the subject. The patch was applied continuously for 24 hours under closed conditions. After the specified time, the patch applicator was removed. After the skin indentation naturally subsided for 0.5 hours, the skin condition at the application site was observed under a standard light source, and irritation manifestations such as erythema, edema, and blisters were recorded. The same site was re-evaluated 24 hours after patch removal. Skin reactions were judged according to the criteria recommended by the International Contact Dermatitis Study Group (ICDRG), as shown in Table 1 below.

[0078] Table 1: The results of the human occlusive patch test were all negative, indicating that the composition prepared by the present invention, which has soothing, anti-allergic and antipruritic effects, meets the requirement of being non-irritating.

[0079] 2. Performance testing methods for TEWL value improvement rate, moisture improvement rate, and erythema improvement rate (1) Subjects and grouping One hundred volunteers aged 18-50 years, regardless of gender, were randomly divided into 10 groups of 10 people each, corresponding to the compositions prepared in Examples 1-3 and Comparative Examples 1-7.

[0080] (2) Testing environment and testing instruments On the day of the test, subjects cleansed their faces with water and then applied no other products. They sat quietly for 20 minutes in an air-conditioned room with a temperature of 21±1℃ and humidity of 50±10% to balance the environment. The Tewameter™ Hex probe was used to measure the transcutaneous water loss (TEWL) value of the facial cheekbone, the CM825 probe was used to measure the stratum corneum moisture content, and the MX18 probe was used to measure the erythema index, serving as the initial values ​​X for each indicator. 初始值 .

[0081] (3) Instant testing All subjects washed their faces six times consecutively with a standard soap-based facial cleanser, each time for approximately one minute. After 10 minutes of rest, the TEWL value and moisture content of the facial cheekbones were measured and recorded as the post-modeling value X. 造模后 Subsequently, 1g of the test composition was evenly applied to the entire face. After leaving it for 10 minutes, the TEWL value and moisture content of the facial cheekbone were tested again and recorded as the value X after immediate use. 使用后 The experiment found that this modeling method did not cause significant facial redness, so the erythema index was not measured immediately during the test.

[0082] (4) Long-term testing After the immediate testing, the subjects applied the corresponding composition to their entire face twice daily, morning and evening, at the normal dosage, for 14 consecutive days. On the 14th day, during a follow-up visit, the TEWL value of the cheekbone, moisture content, and erythema index were tested again under the same environmental conditions and recorded as the values ​​after 14 days of use (X). 使用后 .

[0083] (5) Meaning of the indicator TEWL value: Transepidermal water loss rate; the higher the value, the more severe the barrier damage. Moisture content: The water content of the stratum corneum; the higher the value, the better the moisturizing effect. Erythema index: The degree of facial erythema / telangiectasia; the higher the value, the redder the skin.

[0084] (6) Calculation method of improvement rate Calculate the immediate improvement rate and the 14-day improvement rate using the formula: For TEWL value, a higher improvement rate indicates more complete recovery of transepidermal moisture loss and better skin barrier repair; for moisture content, a higher improvement rate indicates stronger moisturizing and hydrating ability; for erythema index, a higher improvement rate indicates better redness reduction, soothing and anti-allergy effects.

[0085] Table 2: TEWL value and immediate improvement rate of moisture content As shown in Table 2 above, the immediate improvement rates of TEWL and moisture in Examples 1-3 of this invention are significantly higher than those in Comparative Examples 1-7. This indicates that the three key active substances in the composite microgel structure work synergistically to rapidly restore the skin barrier, reduce transepidermal water loss, and quickly increase the moisture content of the stratum corneum after cleansing and stimulation.

[0086] Table 3: Improvement rate of TEWL value, moisture content and erythema at 14 days As shown in Table 3 above, the TEWL improvement rate, moisture improvement rate, and erythema improvement rate of Examples 1-3 of this invention are significantly higher than those of Comparative Examples 1-7. This indicates that the three types of active ingredients in the composite microgel system not only produce immediate effects, but also possess stable long-lasting sustained-release and synergistic soothing capabilities.

[0087] 3. Antipruritic performance test One hundred volunteers with histamine-positive sensitive skin, regardless of gender, in good health and without skin diseases, were selected and randomly divided into 10 groups of 10 people each, corresponding to the compositions prepared in Examples 1-3 and Comparative Examples 1-7.

[0088] Test Method: After establishing an itch model by applying a 1% histamine solution to the forearm skin, different samples were applied. Subjects' subjective feelings of itch relief were recorded at 1 min, 10 min, 30 min, 60 min, 120 min, and 180 min after sample application, and a 1-10 scale was used for quantitative evaluation. The itch relief scores at 1 min, 10 min, and 30 min reflected the product's immediate antipruritic and anti-allergic performance; the itch relief scores at 60 min, 120 min, and 180 min reflected the product's ability to provide sustained relief from itch and discomfort. The score at each time point was the average of all subjects in the group on the corresponding evaluation item; the higher the score, the better the antipruritic and soothing effect.

[0089] Table 4: As shown in Table 4 above, Examples 1-3 of the present invention are significantly superior to Comparative Examples 1-7 in terms of both immediate itch relief and sustained soothing effect. Among them, the compositions prepared in Comparative Examples 1-4 have incomplete structures and unstable activity, resulting in weak itch-relieving ability; the compositions prepared in Comparative Examples 5-7, lacking any one active ingredient, show a significant decrease in long-term soothing ability.

[0090] This specific embodiment is merely an explanation of the present invention and is not intended to limit the invention. After reading this specification, those skilled in the art can make modifications to this embodiment without contributing any inventive step, but such modifications are protected by patent law as long as they are within the scope of the claims of the present invention.

Claims

1. A composition having soothing and anti-irritant antipruritic efficacy, characterized in that, Raw materials including the following weight percentages: oil 10-20%, humectant 5-15%, emulsifier 2-4%, preservative 0.5-1%, composite microgel 3-6%, and the balance being water; The composite microgel has a core-shell structure, the inner core is a calcium alginate gel encapsulating magnolol nano oil droplets and paeonol inclusion compound, and the shell is a gel layer formed by compounding sodium alginate and chitosan containing aphyllanthes extract liposomes.

2. Composition having soothing and anti-irritant antipruritic efficacy according to claim 1, characterized in that, The oil includes evening primrose oil, grape seed oil and squalane at a mass ratio of 1-3:1-3:5-10.

3. The composition for soothing and anti-irritation antipruritic effect according to claim 1, characterized by, The humectant includes glycerol, betaine, L-pyrrolidone-5-sodium carboxylate and sodium hyaluronate at a mass ratio of 10:2-4:0.5-1:0.2-0.

4.

4. The composition for soothing and anti-irritation antipruritic effect according to claim 1, characterized by, The emulsifier includes soy lecithin, cetyl stearyl alcohol and cetyl stearyl glucoside at a mass ratio of 1:1-3:1-3.

5. The composition for soothing and anti-irritation antipruritic effect according to claim 1, characterized by, The preservative includes DL-1,2-hexanediol, p-hydroxyacetophenone and octyloxy glycerol at a mass ratio of 5-10:1:1-2.

6. The composition for soothing and anti-irritation antipruritic effect according to claim 1, characterized by, The magnolol nano oil droplets are prepared by the following method: Magnolol, squalane and hydrogenated lecithin are mixed and heated to dissolve, water is added under stirring to form a coarse emulsion, and the coarse emulsion is subjected to high-pressure microjet homogenization treatment to obtain magnolol nano oil droplets.

7. A composition having soothing and antipruritic effects according to claim 1, characterized in that, The paeonol inclusion compound is prepared by the following method: B1, hydroxypropyl-BETA-cyclodextrin and water are mixed and stirred to dissolve to obtain a hydroxypropyl-BETA-cyclodextrin solution; B2, paeonol is dissolved in anhydrous ethanol to obtain a paeonol solution; B3, the paeonol solution is added to the hydroxypropyl-BETA-cyclodextrin solution, stirred uniformly, and freeze-dried to obtain the paeonol inclusion compound.

8. A composition having soothing and antipruritic effects according to claim 1, characterized in that, The aphyllanthes extract liposomes are prepared by the following method: C1, hydrogenated lecithin, cholesterol and vitamin E are mixed uniformly, anhydrous ethanol is added, and stirred uniformly to obtain a lipid alcohol solution; C2, the aphyllanthes extract is added to deionized water, stirred to dissolve, and filtered to obtain an aphyllanthes extract aqueous solution; C3, the aphyllanthes extract aqueous solution is placed in a high-shear dispersion emulsifier, the lipid alcohol solution is added under stirring, and stirring is continued, after removing anhydrous ethanol by vacuum concentration, an initial emulsion is obtained, and the initial emulsion is subjected to high-pressure homogenization and filtration to obtain aphyllanthes extract liposomes.

9. A composition having soothing and antipruritic effects according to claim 1, characterized in that, The preparation method of the composite microgel includes the following steps: A1, sodium alginate and deionized water are mixed, heated and stirred until completely dissolved to obtain a sodium alginate solution, and the sodium alginate solution is divided into a first portion and a second portion at a mass ratio of 1:2-4; A2, the first portion of the sodium alginate solution is mixed uniformly with the magnolol nano oil droplets and the paeonol inclusion compound to obtain a mixed solution, calcium chloride is dissolved in a mixed solvent to obtain a calcium chloride solution, the mixed solution is added to the calcium chloride solution for crosslinking, after the crosslinking is completed, post-treatment is performed to obtain a pre-crosslinked inner core gel particle; A3, chitosan and water are mixed uniformly, the pH is adjusted to 4-5 with acetic acid, the aphyllanthes extract liposomes are added, and stirred uniformly to obtain a liposome dispersion. A4. Mix the pre-crosslinked core gel particles and the second sodium alginate solution, add the liposome dispersion, stir evenly to obtain a mixed system, add the mixed system to the calcium chloride aqueous solution for secondary crosslinking, after crosslinking is completed, filter, wash and freeze dry to obtain the composite microgel.

10. A process for the preparation of a composition having soothing and antipruritic effects according to any one of claims 1 to 9, characterized in that, Includes the following steps: S1. Weigh out the oils, moisturizers, emulsifiers, preservatives, complex microgels, and water according to the above weight percentages, and set aside. S2. Heat water to 75-80℃, add humectant and preservative, stir to dissolve, and obtain the aqueous phase; S3. Heat the oil to 75-80℃, add the emulsifier, stir evenly, and obtain the oil phase; S4. While stirring, add the oil phase to the aqueous phase and continue stirring to form a matrix emulsion; S5. Keeping the stirring state unchanged, cool the matrix emulsion to 40-45℃, add the composite microgel, stir and disperse, adjust the pH to 5.5-6.5, and obtain the composition.

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