Degradable microneedle temperature control type striae gravidarum repairing film patch and preparation method thereof

The biodegradable microneedle temperature-controlled stretch mark repair patch, which uses a four-layer synergistic system, achieves precise matching with the body's physiological repair rhythm by utilizing temperature-responsive controlled release and microneedle transdermal technology. This solves the problems of insufficient transdermal depth and uncontrollable release, and provides a highly effective stretch mark repair effect.

CN121754441APending Publication Date: 2026-03-31KUNMING MEDICAL UNIVERSITY
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Patent Information

Application Number
CN202511827806.2
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-12-05
Publication Date
2026-03-31

AI Technical Summary

Technical Problem

Existing stretch mark repair technologies suffer from limitations in their effectiveness due to insufficient transdermal depth, uncontrollable release, and disconnection from physiological repair rhythms.

Method used

Employing a four-layer synergistic system, including a nanofiber base layer, a microneedle essence layer, a temperature-controlled adjustment layer, and an adhesion and fixation layer, it constructs a synergistic repair system of perception-response-execution through temperature-responsive controlled release and biodegradable microneedles for active transdermal absorption. This system enables accelerated release of anti-inflammatory components at night and slow release of collagen-promoting components during the day, synchronizing with the body's physiological repair rhythm.

Benefits of technology

It achieves precise synergy between deep transdermal penetration and rhythmic repair, overcoming the problems of low transdermal efficiency and uncontrollable release of traditional membrane patches, and providing an efficient and user-friendly solution for stretch mark repair.

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Abstract

The invention relates to the technical field of cosmetics, and particularly discloses a degradable microneedle temperature control type striae gravidarum repairing film patch and a preparation method thereof. Comprising four layers of structures which are sequentially compounded from outside to inside: a nanofiber substrate layer; a microneedle essence layer; a temperature control adjusting layer; and attaching a fixing layer. By constructing a four-layer collaborative system, the day and night temperature rhythm of the skin is converted into a trigger signal, and a temperature response-microneedle degradation-drug release linkage closed loop is achieved. The degradable microneedle can be utilized to break through a cutin barrier, repair components are accurately delivered to a corium layer, anti-inflammatory and collagen-promoting components can be released at night in an accelerated manner through a temperature control mechanism, and the mode is automatically switched to a slow-release stability maintaining mode in the daytime, so that accurate matching with a human physiological repair rhythm is achieved.
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